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4. Multi-omics approach dissects cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy

5. MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines

6. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region

12. An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm

19. Deep conservation of wrist and digit enhancers in fish

24. Early evolution of the T-box transcription factor family

26. Pluripotency factors regulate the onset of Hox cluster activation in the early embryo

30. Obesity-associated variants within FTO form long-range functional connections with IRX3

31. Active DNA demethylation of developmental cis-regulatory regions predates vertebrate origins

35. 3D genomics across the tree of life reveals condensin II as a determinant of architecture type

36. Odd-skipped genes encode repressors that control kidney development

37. Xenopus Xlmo4 is a GATA cofactor during ventral mesoderm formation and regulates Ldb1 availability at the dorsal mesoderm and the neural plate

39. Asthma-associated variants induce IL33 differential expression through a novel regulatory region

40. The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila

41. Editorial

42. Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes

43. Pluripotency factors regulate the onset of Hox cluster activation in the early embryo

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