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Your search keyword '"Gomez-Puerta, Luis A."' showing total 302 results
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302 results on '"Gomez-Puerta, Luis A."'

2. Concordance between two monoclonal antibody-based antigen detection enzyme-linked immunosorbent assays for measuring cysticercal antigen levels in sera from pigs experimentally infected with Taenia solium and Taenia hydatigena

Author

Arroyo, Gianfranco, Toribio, Luz, Garrido, Sara, Chile, Nancy, Lopez-Urbina, Teresa, Gomez-Puerta, Luis A., Muro, Miguel, Gilman, Robert H., Castillo, Yesenia, Dorny, Pierre, O’Neal, Seth E., Gonzalez, Armando E., and Garcia, Hector H.

Published
2024
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5. Mass chemotherapy with niclosamide for the control of Taenia solium: population-based safety profile and treatment effectiveness

Author

Verastegui, Manuela R., Bustos, Javier A., Zimic, Mirko, Gonzales, Isidro, Saavedra, Herbert, Sanchez, Sofia S., Martinez, Manuel, Castillo, Yesenia, Toribio, Luz, Arroyo, Gianfranco, Orrego, Miguel A., Chile, Nancy, Mayta, Holger, Pajuelo, Monica, Santivañez, Saul, Gonzalez-Gustavson, Eloy, Gomez-Puerta, Luis, Gavidia, Cesar M., Vargas-Calla, Ana, Lopez, Maria T., Nash, Theodore E., Handali, Sukwan, Noh, John, Friedland, Jon, Wardle, Melissa T., Allen, Samantha E., Gamboa, Ricardo, Vilchez, Percy, O'Neal, Seth E., Muro, Claudio, Lescano, Andrés G., Moyano, Luz M., Gonzalvez, Guillermo E., González, Armando E., Gilman, Robert H., and García, Héctor H.

Published
2024
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18. Echinococcus

Author

Gonzalez, Armando, Gomez-Puerta, Luis A., Doyle, Michael P., Series editor, Ortega, Ynés R., editor, and Sterling, Charles R., editor

Published
2018
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27. Antibody Banding Patterns on the Enzyme-Linked Immunoelectrotransfer Blot (EITB) Assay Clearly Discriminate Viable Cysticercosis in Naturally Infected Pigs.

Author

Arroyo, Gianfranco, Lescano, Andres G., Gavidia, Cesar M., Lopez-Urbina, Teresa, Ara-Gomez, Miguel, Gomez-Puerta, Luis A., Bustos, Javier A., Jayashi, Cesar M., O'Neal, Seth E., Gonzalez, Armando E., and Garcia, Hector H.

Subjects
CYSTICERCOSIS, SWINE, TAENIA solium, IMMUNOGLOBULINS, ANTIGENS, SWINE farms
Abstract

Enzyme-linked immunoelectrotransfer blot (EITB) detects antibodies against seven Taenia solium larvae antigens in three protein families (GP50, T24/42, and 8-kDa) with different structures and functions. EITB banding patterns against these antigens in pigs provide information about the course of infection and may discriminate viable cysticercosis. We analyzed the banding patterns and infection outcomes (presence of viable cysts, degenerated cysts, and any cysts) of 512 rural pigs. Banding patterns were grouped into homogenous classes using latent class analysis, and relationships with infection outcomes were assessed. Four classes were identified: 1 (n = 308, EITB-negative or positive for the GP50 family), 2 (n = 127, positive for GP50 (GP50 family), GP42-39 and GP24 (T24/42 family), but negative for 8-kDa antigens), 3 (n = 22, positive for GP50 and T24/42 antigens (GP42-39 and GP24), as well as to 8-kDa bands GP13, GP14, and GP18, but negative for GP21), and 4 (n = 55, positive for GP50 and T24/42 antigens, as well as to 8-kDa antigens GP21 and GP18 in combination). Pigs in classes 3 and 4 were more likely to have viable cysts (72.6% and 96.4%, respectively) than pigs in classes 1 and 2 (0.7% and 27.6%, respectively; p < 0.001). The number of infections with any cysts was higher in classes 3 and 4 (77.3% and 98.2%, respectively) and lower in classes 2 and 1 (34.7% and 4.9%, respectively; p < 0.001). Pigs with viable cysts represented >90% of pigs with any cysts in classes 3 and 4 (94.1% and 98.2%, respectively), while degenerated cysts were frequent among pigs with any cysts in classes 1, 3, and 2 (86.7%, 47.1%, and 43.2%, respectively; p < 0.001). EITB banding patterns strongly correlate with cysticercosis infection status in rural pigs, with classes 3 and 4 being more predictive of viable infections. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study

Author

Gonzales-Gustavson, Eloy, primary, Pray, Ian W., additional, Gamboa, Ricardo, additional, Muro, Claudio, additional, Vilchez, Percy, additional, Gomez-Puerta, Luis, additional, Vargas-Calla, Ana, additional, Bonnet, Gabrielle, additional, Pizzitutti, Francesco, additional, Garcia, Hector H., additional, Gonzalez, Armando E., additional, and O’Neal, Seth E., additional

Published
2023
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36. A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

Author

Douglas, Alexander D., Baldeviano, G. Christian, Jin, Jing, Miura, Kazutoyo, Diouf, Ababacar, Zenonos, Zenon A., Ventocilla, Julio A., Silk, Sarah E., Marshall, Jennifer M., Alanine, Daniel G. W., Wang, Chuan, Edwards, Nick J., Leiva, Karina P., Gomez-Puerta, Luis A., Lucas, Carmen M., Wright, Gavin J., Long, Carole A., Royal, Joseph M., and Draper, Simon J.

Published
2019
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43. Polycystic echinococcosis in Pacas, Amazon Region, Peru

Author

Mayor, Pedro, Baquedano, Laura E., Sanchez, Elisabeth, Aramburu, Javier, Gomez-Puerta, Luis A., Mamani, Victor J., and Gavidia, Cesar M.

Subjects
Prevalence studies (Epidemiology) -- Usage, Echinococcosis -- Causes of -- Distribution -- Drug therapy -- Research, Company distribution practices, Health
Abstract

In the Peruvian Amazon, paca meat is consumed by humans. To determine human risk for polycystic echinococcosis, we examined wild pacas from 2 villages; 15 (11.7%) of 128 were infected [...]

Published
2015
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46. Development of a dose-response model for porcine cysticercosis

Author

Andrade-Mogrovejo, Daniel A, Gonzales-Gustavson, Eloy, Ho-Palma, Ana C, Prada, Joaquín M, Bonnet, Gabrielle, Pizzitutti, Francesco, Gomez-Puerta, Luis A, Arroyo, Gianfranco, O'Neal, Seth E, Garcia, Hector H, Guitian, Javier, Gonzalez, Armando, and Cysticercosis Working Group in Peru

Abstract

Taenia solium is an important cause of acquired epilepsy worldwide and remains endemic in Asia, Africa, and Latin America. Transmission of this parasite is still poorly understood despite the design of infection experiments to improve our knowledge of the disease, with estimates for critical epidemiological parameters, such as the probability of human-to-pig infection after exposure to eggs, still lacking. In this paper, a systematic review was carried out and eight pig infection experiments were analyzed to describe the probability of developing cysts. These experiments included different pathways of inoculation: with ingestion of proglottids, eggs, and beetles that ingested eggs, and direct injection of activated oncospheres into the carotid artery. In these experiments, different infective doses were used, and the numbers of viable and degenerated cysts in the body and brain of each pig were registered. Five alternative dose-response models (exponential, logistic, log-logistic, and exact and approximate beta-Poisson) were assessed for their accuracy in describing the observed probabilities of cyst development as a function of the inoculation dose. Dose-response models were developed separately for the presence of three types of cysts (any, viable only, and cysts in the brain) and considered for each of the four inoculation methods ("Proglottids", "Eggs", "Beetles" and "Carotid"). The exact beta-Poisson model best fit the data for the three types of cysts and all relevant exposure pathways. However, observations for some exposure pathways were too scarce to reliably define a dose-response curve with any model. A wide enough range of doses and sufficient sample sizes was only found for the "Eggs" pathway and a merged "Oral" pathway combining the "Proglottids", "Eggs" and "Beetles" pathways. Estimated parameter values from this model suggest that a low infective dose is sufficient to result in a 50% probability for the development of any cyst or for viable cyst infections. Although this is a preliminary model reliant on a limited dataset, the parameters described in this manuscript should contribute to the design of future experimental infections related to T. solium transmission, as well as the parameterization of simulation models of transmission aimed at informing control.

Published
2022

47. Development of a dose-response model for porcine cysticercosis

Author

Andrade-Mogrovejo, Daniel A., Gonzales-Gustavson, Eloy, Ho-Palma, Ana C., Prada, Joaquin M., Bonnet, Gabrielle, Pizzitutti, Francesco, Gomez-Puerta, Luis A., Arroyo Hurtado, Gianfranco, O'Neal, Seth E., García Lescano, Héctor Hugo, Guitian, Javier, and Gonzalez Zariquiey, Armando Emiliano

Subjects
Beetles, Swine, Cysticercosis, Eggs, Ingestion, parasitic diseases, Pig models, Parasitic diseases, Database searching
Abstract

Taenia solium is an important cause of acquired epilepsy worldwide and remains endemic in Asia, Africa, and Latin America. Transmission of this parasite is still poorly understood despite the design of infection experiments to improve our knowledge of the disease, with estimates for critical epidemiological parameters, such as the probability of human-to-pig infection after exposure to eggs, still lacking. In this paper, a systematic review was carried out and eight pig infection experiments were analyzed to describe the probability of developing cysts. These experiments included different pathways of inoculation: with ingestion of proglottids, eggs, and beetles that ingested eggs, and direct injection of activated oncospheres into the carotid artery. In these experiments, different infective doses were used, and the numbers of viable and degenerated cysts in the body and brain of each pig were registered. Five alternative dose-response models (exponential, logistic, log-logistic, and exact and approximate beta-Poisson) were assessed for their accuracy in describing the observed probabilities of cyst development as a function of the inoculation dose. Doseresponse models were developed separately for the presence of three types of cysts (any, viable only, and cysts in the brain) and considered for each of the four inoculation methods ("Proglottids", "Eggs", "Beetles"and "Carotid"). The exact beta-Poisson model best fit the data for the three types of cysts and all relevant exposure pathways. However, observations for some exposure pathways were too scarce to reliably define a dose-response curve with any model. A wide enough range of doses and sufficient sample sizes was only found for the "Eggs"pathway and a merged "Oral"pathway combining the "Proglottids", "Eggs"and "Beetles"pathways. Estimated parameter values from this model suggest that a low infective dose is sufficient to result in a 50% probability for the development of any cyst or for viable cyst infections. Although this is a preliminary model reliant on a limited dataset, the parameters described in this manuscript should contribute to the design of future experimental infections related to T. solium transmission, as well as the parameterization of simulation models of transmission aimed at informing control.

Published
2022

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