39 results on '"Gomez-Perez L"'
Search Results
2. Is the adjustable TVA mesh effective for the long-term treatment of female stress incontinence?
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Romero-Maroto, J., Pérez-Seoane, H., Gómez-Perez, L., Pérez-Tomás, C., Pacheco-Bru, J.J., and López-López, A.
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- 2017
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3. Mechanisms of Bacterial Extracellular Electron Exchange
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White, G.F., primary, Edwards, M.J., additional, Gomez-Perez, L., additional, Richardson, D.J., additional, Butt, J.N., additional, and Clarke, T.A., additional
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- 2016
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4. Mortality prediction models after radical cystectomy for bladder tumour: A systematic review and critical appraisal
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Sarrio-Sanz P, Martinez-Cayuelas L, Lumberas B, Sanchez-Caballero L, Palazon-Bru A, Gil-Guillen V, and Gomez-Perez L
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models ,urinary bladder neoplasms ,mortality ,radical cystectomy ,nomograms - Abstract
Introduction To identify risk-predictive models for bladder-specific cancer mortality in patients undergoing radical cystectomy and assess their clinical utility and risk of bias. Methods Systematic review (CRD42021224626:PROSPERO) in Medline and EMBASE (from their creation until 31/10/2021) was screened to include articles focused on the development and internal validation of a predictive model of specific cancer mortality in patients undergoing radical cystectomy. CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies (CHARMS) and Prediction model Risk Of Bias ASsessment Tool (PROBAST) were applied. Results Nineteen observational studies were included. The main predictors were sociodemographic variables, such as age (18 studies, 94.7%) and sex (17, 89.5% studies), tumour characteristics (TNM stage (18 studies, 94.7%), histological subtype/grade (15 studies, 78.9%), lymphovascular invasion (10 studies, 52.6%) and treatment with chemotherapy (13 studies, 68.4%). C-index values were presented in 14 studies. The overall risk of bias assessed using PROBAST led to 100% of studies being classified as high risk (the analysis domain was rated to be at high risk of bias in all the studies), and 52.6% showed low applicability. Only 5 studies (26.3%) included an external validation and 2 (10.5%) included a prospective study design. Conclusions Using clinical predictors to assess the risk of bladder-specific cancer mortality is a feasibility alternative. However, the studies showed a high risk of bias and their applicability is uncertain. Studies should improve the conducting and reporting, and subsequent external validation studies should be developed.
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- 2022
5. Genito Pelvic Pain/Penetration Disorder (GPPPD) in Spanish Women-Clinical Approach in Primary Health Care: Review and Meta-Analysis
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Berenguer-Soler M, Navarro-Sanchez A, Compan-Rosique A, Luri-Prieto P, Navarro-Ortiz R, Gomez-Perez L, Perez-Tomas C, Font-Julia E, Gil-Guillen V, Cortes-Castell E, Navarro-Cremades F, Montejo A, Arroyo-Sebastian M, and Perez-Jover V
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primary health care ,female ,Spanish scientific publications ,penetration pain disorder ,vaginismus ,Spain ,dyspareunia ,genito-pelvic ,vulvodynia ,women ,sexual pain - Abstract
Sexuality is a component of great relevance in humans. Sexual disorders are a major public health problem representing a high prevalence in the general population. DSM-5 genito-pelvic pain/penetration disorder (GPPPD) includes dyspareunia and vaginismus (DSM-IV-TR). To assess the importance of research on these disorders in Spain, we evaluated the Spanish scientific publications of primary and community care. The objective was to quantify the magnitude of the publications of GPPPD in Spanish women in primary and community care. For this, we used the method of conducting a systematic review and meta-analysis of studies evaluating GPPPD. As main results, of the 551 items found, we selected 11 studies that met the inclusion criteria. In primary care in Spain, one in nine women has these disorders; the percentage of women with GPPPD in this study (raw data) was 11.23% (95% CI: 0-29%) (vaginismus 5%; penetration pain 8.33%; dyspareunia 16.45%). These percentages can differ of those from other countries, and they are at the top of the data of the European countries (9-11.9%). There is much variability in the studies found in the world with respect to the prevalence of these health problems.
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- 2022
6. mRNA-1273 SARS-CoV-2 vaccine safety and COVID-19 risk perception in recently transplanted allogeneic hematopoietic stem cell transplant recipients
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Albiol, N, Barata, A, Aso, O, Gomez-Perez, L, Triquell, M, Roch, N, Lazaro, E, Esquirol, A, Gonzalez, I, Lopez-Contreras, J, Sierra, J, Martino, R, and Garcia-Cadenas, I
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mRNA-1273 ,Risk perception ,Adverse events ,COVID-19 ,Allogeneic stem cell transplantation - Abstract
Purpose This study aims to describe the incidence and severity of adverse events (AEs) following the mRNA-1273 SARS-CoV-2 vaccine and explore the risk perception of COVID-19 in allogeneic hematopoietic stem cell transplant (HCT) recipients. Methods We performed a single-center prospective study including recently transplanted (< 2 years post-infusion) allogeneic HCT recipients. AEs were assessed through phone calls and graded from 0 to 4, while COVID-19 risk perception was measured using the Brief Illness Perception Questionnaire (BIP-Q5). Results Fifty-four HCT recipients were evaluated. Incidence and grades of AE (94.4% and 85.2% after the first and second dose, respectively) were similar to those described in the general population. The most common AE was pain at the site of injection. Three patients (5.6%) developed a grade >= 3 AE. Vaccine-related cytopenias and graft-versus-host disease flares were not observed. Female sex (OR 3.94, 95% CI 1.14-13.58, p = 0.03) and time since HCT (per month since HCT: OR 1.09, 95% CI 1.01-1.18, p = 0.04) were associated with the occurrence of any AE. The patients' risk perception level of COVID-19 decreased over time (p < 0.05). Conclusion Our study confirms that the mRNA-1273 SARS-CoV-2 vaccine is safe in recent HCT recipients and suggests that the perceived risk of COVID-19 decreases over time.
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- 2022
7. Impact of urinary incontinence and overactive bladder syndrome on health-related quality of life of working middle-aged patients and institutionalized elderly patients
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Martínez Agulló, E., Ruíz Cerdá, J.L., Gómez Pérez, L., Rebollo, P., Pérez, M., and Chaves, J.
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- 2010
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8. P234 - Comparing toxicity and short term outcomes of Hyperthermic Intravesical Chemotherapy with Mitomycin-C versus Intravesical Chemotherapy with Mitomycin-C alone in the management of intermediate risk non-muscle invasive bladder cancer
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Ramos Rodriguez, E., Garcia Carceles, N., Ferrández Jiménez, M., Domingo Latorre, D., Albertus, A., García Seguí, A., Soler Lopez, C., and Gómez Pérez, L.
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- 2023
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9. A Systematic Review of Clinical Trials Assessing Sexuality in Hysterectomized Patients
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Martinez-Cayuelas L, Sarrio-Sanz P, Palazon-Bru A, Verdu-Verdu L, Lopez-Lopez A, Gil-Guillen V, Romero-Maroto J, and Gomez-Perez L
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abdominal ,vaginal ,hysterectomy ,sexuality - Abstract
In hysterectomized patients, even though there is still controversy, evidence indicates that in the short term, the vaginal approach shows benefits over the laparoscopic approach, as it is less invasive, faster and less costly. However, the quality of sexual life has not been systematically reviewed in terms of the approach adopted. Through a systematic review, we analyzed (CRD42020158465 in PROSPERO) the impact of hysterectomy on sexual quality and whether there are differences according to the surgical procedure (abdominal or vaginal) for noncancer patients. MEDLINE (through PubMed), Embase, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Scopus were reviewed to find randomized clinical trials assessing sexuality in noncancer patients undergoing total hysterectomy, comparing vaginal and abdominal (laparoscopic and/or open) surgery. Three studies that assessed the issue under study were finally included. Two of these had a low risk of bias (Cochrane risk of bias tool); one was unclear. There was significant variability in how sexuality was measured, with no differences between the two approaches considered in the review. In conclusion, no evidence was found to support one procedure (abdominal or vaginal) over another for non-oncological hysterectomized patients regarding benefits in terms of sexuality.
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- 2021
10. Long-term effectiveness and safety of bladder augmentation in spina bifida patients
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Romero-Maroto J, Martinez-Cayuelas L, Gomez-Perez L, Sarrio-Sanz P, Barragan E, and Lopez-Lopez A
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spina bifida ,detubularized augmentation cystoplasty ,continence ,bladder dysfunction - Abstract
Aims To establish the long-term efficacy and safety of bladder augmentation in spina bifida patients. Material and Methods Sixteen patients were operated on using the Bramble technique. Preoperative and postoperative evaluation included clinical history, blood tests, urine cultures, cystography, pyelography, ultrasound, and filling cystometry. In the final review a standardized quality of life questionnaire was applied. Results Median follow-up was 20 years (15-26). Kidney function was stabilized except for one case that required a kidney transplant. Hydronephrosis disappeared or improved (p = 0.03). Vesicoureteral reflux grades I-II was cured without reimplantation and grades III-IV responded better with reimplantation than without (p = 0.03). Quality of life improved in all patients, with all stating they would undergo the procedure again. After surgery, 94% of the patients exhibited diurnal continence but 25% exhibited nocturnal incontinence. Pressure at capacity decreased and bladder capacity increased (p < 0.001). One patient presented ureteral fistula with another presenting hemorrhage. Both required immediate surgical review. Late complications included urinary sphincter cuff erosion, renal lithiasis, four instances of bladder lithiasis and repeated pyelonephritis in one 24-year-old patient. All required surgery. The mean of urinary infections fell, from 2.5 per year (0.7) to 1 (0.5) (p = 0.03). Conclusion Augmentation cystoplasty (AC) maintains its efficacy and improves quality of life in the long term. However, serious surgical complications can ensue, along with minor or major subsequent complications. This should be considered before surgery and makes lifelong monitoring of patients necessary.
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- 2021
11. High-flow Priapism in Pediatric Population: Case Series and Review of the Literature
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Sarrio-Sanz P, Martinez-Cayuelas L, March-Villalba J, Lopez-Lopez A, Rodriguez-Caraballo L, Sanchez-Caballero L, Polo-Rodrigo A, Nakdali-Kassab B, Conca-Baenas M, Gomez-Garberi M, Pacheco-Bru J, Perez-Seoane-Ballester H, Perez-Tomas C, Gomez-Perez L, Ortiz-Gorraiz M, and Serrano-Durba A
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Conservative management ,Pediatric population ,High-flow priapism - Abstract
Introduction: Priapism is a prolonged erection that lasts longer than four hours. It is a rarepathology in the pediatric population, with an estimation of 0.3-1.5 per 100,000 children peryear. The diagnostic sequence includes clinical history, physical examination and penile Dopplerultrasound (PDUS). Puncture of corpora cavernosa is not always necessary to establish thedifferential diagnosis between high-flow and low-flow priapism. The treatment of choice inpediatric age is not well defined. Patients and methods: Multicentric, retrospective and descriptive study including patientsunder 14 years with high-flow priapism between 2010 and 2020. Literature review. Results: A total of seven patients were diagnosed with high-flow priapism. None of them required puncture of the corpora cavernosa. Patients were treated with a conservative management, two patients required superselective arterial embolization due to persistent symptoms. Conclusions: High-flow priapism is a very rare entity in pediatric age; therefore, knowing theproper diagnosis and management is crucial. Currently, penile doppler ultrasound is enough fordiagnosis in most cases and allows obviating the use of blood gas analysis. Children should beinitially treated with a conservative management, reserving embolization for refractory cases. (c) 2021 AEU. Published by Elsevier Espana, S.L.U. All rights reserved.
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- 2021
12. The Thiel cadaveric model for pelvic floor surgery: Best rated in transferable simulation-based training for postgraduate studies
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Soler-Silva A, Sanchis-Lopez A, Sanchez-Guillen L, Lopez-Rodriguez-Arias F, Gomez-Perez L, Quiros M, Sanchez-Ferrer M, Escoriza J, Munoz-Duyos A, Ramirez J, and Arroyo A
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body regions ,Laparoscopic simulation ,Surgical simulation ,Pelvic floor simulation ,Cadaveric simulation ,Anatomical knowledge ,Perineal surgery - Abstract
Objective: To determine whether the Thiel cadaveric model is better and more realistic than other surgical simulation techniques for learning pelvic floor and perineal surgical procedures according to the opinions of urogynecologists and surgeons participating in international postgraduate pelvic floor surgery courses using cadavers embalmed by the Thiel method. Study Design: An observational prospective study was performed in urogynecologists and surgeons attending international postgraduate pelvic floor and perineal surgery courses using cadavers embalmed by the Thiel method. A survey was completed by the participants after finishing the course. Based on the answers collected, we analyzed the differences, including in the satisfaction degree and teaching level for each surgical procedure, between different surgical simulation models that the participants had already used and the Thiel simulation method employed. Results: The students recognized that Thiel cadavers present more similarities to patients than other simulation methods. The Thiel cadaveric method was considered by most responders to be the best for the simulation of surgical procedures on the pelvic floor and perineum. Most of the surgeons surveyed recommended conducting these courses with Thiel cadavers for different colleagues in other specialties as a reliable simulation method for training for difficult surgical procedures. Conclusions: Participants in the course on pelvic floor surgery in Thiel cadavers recognized that this is the most realistic model for surgical simulation and the best way to gain confidence, self-determination and precise surgical skills for performing pelvic floor and perineal surgery. (C) 2020 Elsevier B.V. All rights reserved.
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- 2021
13. Changes in Spirometric Parameters and Arterial Oxygen Saturation During a Mountain Ascent to Over 3000 Meters
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Compte-Torrero, L., Botella de Maglia, J., de Diego-Damiá, A., Gómez-Pérez, L., Ramírez-Galleymore, P., and Perpiñá-Tordera, M.
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- 2005
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14. Cambios espirométricos y en la saturación arterial de oxígeno durante la ascensión a una montaña de más de 3.000 metros
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Compte-Torrero, L., Botella de Maglia, J., de Diego-Damiá, A., Gómez-Pérez, L., Ramírez-Galleymore, P., and Perpiñá-Tordera, M.
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- 2005
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15. Can the simultaneous laparoscopic approach improve the learning of vaginal surgery with meshes in the anatomical model?
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Sanchez-Ferrer M, Fernandez-Andres I, Martinez-Escoriza J, Romero-Maroto J, del Campo F, and Gomez-Perez L
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vaginal mesh ,anatomical knowledge ,surgical skills ,Thiel anatomical model ,laparoscopic approach - Abstract
Aims To evaluate the usefulness of simultaneous laparoscopic assistance to improve understanding of the nonvisible surgical steps in Thiel-embalmed cadaver models for training in vaginal surgery using vaginal mesh kits and to evaluate opinions of this surgical learning procedure in comparison with other learning models. Methods Recording of anterior compartment prolapse repair with vaginal mesh kits using an external camera simultaneously with laparoscopic vision during the execution of the procedure at the dissection room. To measure the usefulness of this procedure, we designed an anonymous online survey that was made available to program participants via a computer application (a link to video 1 and the survey is available at encuesta@um.es). Results After watching the video, 97.2% of participants agreed that laparoscopic vision combined with the vaginal approach was useful in learning this surgical technique, and 95.8% agreed they had learned details of the surgical anatomy of the pelvis. All participants agreed that it should be mandatory to train in these techniques with cadavers before practice with live patients. In addition, 84.7% responded that the cadaveric model was superior to animal and other types of models. Conclusion Laparoscopic inspection of the procedure performed with the vaginal approach allowed a better understanding of the surgical technique by making "visible" the anatomical structures that were commonly only palpated. Use of the cadaverous model was considered most efficient for training in this surgical technique.
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- 2019
16. Factors associated with false negative and false positive results of prostate-specific antigen (PSA) and the impact on patient health: Cohort study protocol
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Bernal-Soriano M, Parker L, Lopez-Garrigos M, Hernandez-Aguado I, Caballero-Romeu J, Gomez-Perez L, Alfayate-Guerra R, Pastor-Valero M, Garcia N, and Lumbreras B
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false negative reactions ,false positive reactions ,prostate-specific antigen ,prostate disease ,quality in health care - Abstract
Introduction: Prostate-specific antigen (PSA) is the main tool for early detection, risk stratification and monitoring of prostate cancer (PCa). However, there are controversies about the use ofPSAas a population screening test because of the high potential for overdiagnosis and overtreatment associated. The net benefit of screening is unclear and according to the available recommendations, it should be offered to well-informedmen with an adequate health status and a life-expectancy of at least 10 years or tomen at elevated risk of having PCa. In addition, the factors that influence test results are unclear, as is impact of false positive or negative results on patient health. Our objective is to assess the clinical and analytical factors associated with the presence of false positive and false negative results and the diagnostic/therapeutic process followed by these patients. Methods and analysis: A prospective observational cohort study will be carried out. We will include a cohort of patients with a positive PSA result (1.081 patients) and a sample of patients with negative results (572 patients); both will be followed for 2 years by reviewingmedical records to assess the variables associated with these results, as well as characteristics of patient management after a positive PSA value. We will include those patients with a PSA determination from2 hospitals in the Valencian Community. Patients who have been previously diagnosed with prostate cancer or who are being followed for previous high PSA values will be excluded. Discussion: The study will estimate the frequency of false positive and false negative PSA results in routine clinical practice, and allow us to quantify the potential harm caused. Study registration: Clinicaltrials.gov (https://clinicaltrials.gov/): NCT03978299, June 7, 2019.
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- 2019
17. Lateral-based Anterior Vaginal Wall Flap in the Treatment of Female Urethral Stricture: Efficacy and Safety
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Romero-Maroto J, Verdu-Verdu L, Gomez-Perez L, Perez-Tomas C, Pacheco-Bru J, and Lopez-Lopez A
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Augmentation urethroplasty ,Vaginal wall flap urethroplasty ,Lower urinary tract symptoms ,Female urethral stricture - Abstract
Background: Female urethral stricture is a rare condition. Different types of urethroplasty have been described. However, high quality studies are sparse. The most common technique used-the Blandy's technique-has resulted in our cases in a retrusive meatus and an inward urinary stream. Objective: To show the efficacy and safety of an alternative vaginal wall flap urethroplasty. Design, setting, and participants: A cross-sectional observational study was undertaken in a single University Hospital. Nine female patients previously diagnosed with urethral stricture at our institution underwent open surgery from 1993 to 2015. They were contacted and agreed to undergo a medical examination. Surgical procedure: A ventral lateral-based anterior vaginal wall flap urethroplasty inspired by the Orandi technique for male urethroplasty was performed. Measurements: A chart review was performed. Results and limitations: The mean age was 56 yr (41-78 yr). The mean follow-up was 80.7 mo (12-198). All patients had relief of symptoms. The meatus of all patients stayed in an orthotopic position without any impact on the direction of the urinary stream. The average caliber of the urethra increased from 10.8 Fr (6-18 Fr) to >= 20 Fr. Peak flow improved from a mean of 6.8 ml/s (3-11 ml/s) to 21 ml/s (14-35 ml/s). No patient developed stricture recurrence or de novo stress urinary incontinence. There were no other immediate or delayed complications. All patients achieved a better score on the Patient Global Impression of Improvement questionnaire. Conclusions: Our study, with the same limitations that the few studies published in this field had, that is the few patients included, demonstrates that lateral anterior vaginal wall flap urethroplasty is an effective technique, offering durable results without apparent complications. (C) 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved.
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- 2018
18. P.1.k.015 - Mirror-image study of aripiprazole long-acting injectable for the treatment of psychiatric patients attended in community mental health team
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León Caballero, J., Córcoles, D., Gómez-Perez, L., Sánchez, R., Jose Ignacio, C., Herminia, M., Mas, R., and Diez-Aja, C.
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- 2017
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19. 910 – Schizophrenia and violence at home
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Nascimento Osorio, M.T., primary, Sabate Gomez, A., additional, Corcoles Martinez, D., additional, Gines Miranda, J.M., additional, Gomez Perez, L., additional, Bellsola Gonzalez, M., additional, Gonzalez Fresnedo, A.M., additional, Martin Lopez, L.M., additional, Bulbena Vilarassa, A., additional, Gasque Llopis, S., additional, and Castillo Magaña, S., additional
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- 2013
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20. Chapter Three - Mechanisms of Bacterial Extracellular Electron Exchange.
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White, G. F., Edwards, M. J., Gomez-Perez, L., Richardson, D. J., Butt, J. N., and Clarke, T. A.
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The biochemical mechanisms by which microbes interact with extracellular soluble metal ions and insoluble redox-active minerals have been the focus of intense research over the last three decades. The process presents two challenges to the microorganism. Firstly, electrons have to be transported at the cell surface, which in Gram-negative bacteria presents an additional problem of electron transfer across the ~ 6 nm of the outer membrane. Secondly, the electrons must be transferred to or from the terminal electron acceptors or donors. This review covers the known mechanisms that bacteria use to transport electrons across the cell envelope to external electron donors/acceptors. In Gram-negative bacteria, electron transfer across the outer membrane involves the use of an outer membrane β-barrel and cytochrome. These can be in the form of a porin-cytochrome protein, such as Cyc2 of Acidithiobacillus ferrooxidans, or a multiprotein porin-cytochrome complex like MtrCAB of Shewanella oneidensis MR-1. For mineral-respiring organisms, there is the additional challenge of transferring the electrons from the cell to mineral surface. For the strict anaerobe Geobacter sulfurreducens this requires electron transfer through conductive pili to associated cytochrome OmcS that directly reduces Fe(III)oxides, while the facultative anaerobe S. oneidensis MR-1 accomplishes mineral reduction through direct membrane contact, contact through filamentous extensions and soluble flavin shuttles, all of which require the outer membrane cytochromes MtrC and OmcA in addition to secreted flavin. [ABSTRACT FROM AUTHOR]
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- 2016
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21. Endogenous Rho-Kinase Signaling Maintains Synaptic Strength by Stabilizing the Size of the Readily Releasable Pool of Synaptic Vesicles
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Gonzalez-Forero, D., primary, Montero, F., additional, Garcia-Morales, V., additional, Dominguez, G., additional, Gomez-Perez, L., additional, Garcia-Verdugo, J. M., additional, and Moreno-Lopez, B., additional
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- 2012
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22. Decreased Incidence of Readmission in First Episode Psychosis in Treatment with Long – Acting Injectable Antipsychotics
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Toll, A., Mané, A., Bergé, D., Gómez – Pérez, L., Samsó, B., Chavarria, V., and Pérez – Solà, V.
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- 2015
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23. 695 DOES PRESSURE FLOW STUDY IMPROVE THE OUTCOME OF SURGERY IN WOMEN WITH SUI?
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Romero, Maroto J., primary, Ortiz, Gorraiz M.A., additional, Gomez, Perez L., additional, Lopez, Lopez A., additional, Sanchez, A., additional, and Pacheco, Bru J.J., additional
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- 2010
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24. 721 PREVALENCE OF URINARY INCONTINENCE AND OVERACTIVE BLADDER SYNDROME (APPLYING THE ICS DEFINITIONS) AMONG SPANISH WOMEN USING A FACE-TO-FACE INTERVIEW
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Ruiz Cerda, J.L., primary, Ramirez Backhaus, M., additional, Gomez Perez, L., additional, Arlandis Guzman, S., additional, Exposito Martin, I., additional, Gonzalez Segura, D., additional, and Martinez Agullo, E., additional
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- 2007
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25. 1769 – Psychotic disorder and hospitalization through mobile crisis unit
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Gómez Pérez, L., Nascimento Osorio, M.T., Sabaté Gómez, A., Córcoles Martínez, D., Malagón Amor, Á., Álvaro Serón, P., Bellsolà, M., González, A., Martín López, L.M., and Bulbena Vilarrasa, A.
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- 2013
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26. 960 TRAUMATIC EVENT HISTORIES, PTSD SYMPTOMS, RESILIENCE, PAIN ACCEPTANCE, PROCEDURAL VARIABLES AND DISABILITY IN WOMEN WITH CHRONIC PAIN
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Ruiz-Párraga, G., López-Martínez, A., Gómez-Pérez, L., Ramírez-Maestre, C., and Gómez, I. Barranquero
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- 2009
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27. 959 RELATIONSHIP BETWEEN A HISTORY OF PHYSICAL, SEXUAL AND EMOTIONAL MALTREATMENT AND DISABILITY IN WOMEN WITH CHRONIC PAIN
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Ruiz-Párraga, G., López-Martínez, A., and Gómez-Pérez, L.
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- 2009
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28. 833 FACTOR STRUCTURE OF THE SPANISH VERSION OF THE TAMPA SCALE FOR KINESIOPHOBIA (TSK) IN CHRONIC AND ACUTE PAIN PATIENTS
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Gómez Pérez, L., López Martínez, A.E., Ruíz Párraga, G.T., Camacho-Martel, L., and Alba-Castermeiro, M.A.
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- 2009
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29. 763 RELIABILITY AND VALIDITY OF THE SPANISH VERSION OF THE TAMPA SCALE FOR KINESIOPHOBIA (TSK) IN CHRONIC AND ACUTE PAIN PATIENTS
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Gómez Pérez, L., López Martínez, A.E., and Párraga, G.T. Ruíz
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- 2009
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30. Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity.
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Worthy AE, Anderson JT, Lane AR, Gomez-Perez L, Wang AA, Griffith RW, Rivard AF, Bikoff JB, and Alvarez FJ
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Spinal cord interneurons play critical roles shaping motor output, but their precise identity and connectivity remain unclear. Focusing on the V1 interneuron cardinal class we defined four major V1 subsets according to neurogenesis timing, genetic lineage-tracing, synaptic output to motoneurons, and synaptic inputs from muscle afferents. Birthdate delineates two early born (Renshaw and Pou6f2) and two late born (Foxp2 and Sp8) V1 clades, showing that sequential neurogenesis produces different V1 subsets. Early born Renshaw cells and late born Foxp2-V1 interneurons are tightly coupled to motoneurons, while early born Pou6f2-V1 and late born Sp8-V1 interneurons are not, indicating that timing of neurogenesis does not correlate with motoneuron targeting. V1 clades also differ in cell numbers and diversity. Lineage labeling shows that the Foxp2-V1 clade contains over half of all V1 interneurons, provides the largest inhibitory input to motoneuron cell bodies and includes subgroups that differ in birthdate, location, and proprioceptive input. Notably, one Foxp2-V1 subgroup, defined by postnatal Otp expression is positioned near the lateral motor column and receives substantial input from proprioceptors, consistent with an involvement in reciprocal inhibitory pathways. Combined tracing of ankle flexor sensory afferents and interneurons monosynaptically connected to ankle extensors confirmed placement of Foxp2-V1 interneurons in reciprocal inhibitory pathways. Our results validate previously proposed V1 clades as unique functional subtypes that differ in circuit placement, with Foxp2-V1 cells forming the most heterogeneous subgroup. We discuss how V1 organizational diversity enables understanding of their roles in motor control, with implications for their diverse ontogenetic and phylogenetic origins., Significance Statement: The complexity of spinal interneuron diversity and circuit organization represents a challenge to understand neural control of movement in normal adults as well as during motor development and in disease. Inhibitory interneurons are a core element of these spinal circuits. V1 interneurons comprise the largest group of inhibitory interneurons in the ventral horn, and their organization remains unclear. Here we present a comprehensive examination of V1 subtypes according to neurogenesis, placement in spinal motor circuits, and motoneuron synaptic targeting. V1 diversity increases during evolution from axial-swimming fishes to limb-based mammalian terrestrial locomotion. This increased diversity is reflected in the size and heterogeneity of the Foxp2-V1 clade, a group closely associated with limb motor pools. We show that Foxp2-V1 interneurons establish the densest direct inhibitory input to motoneurons, especially on cell bodies. These findings are particularly significant because recent studies have shown that motor neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) affect inhibitory V1 synapses on motoneuron cell bodies and Foxp2-V1 interneurons themselves in the earliest stages of pathology.
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- 2024
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31. A Novel Decision Tree Model for Predicting the Cancer-Specific Survival of Patients with Bladder Cancer Treated with Radical Cystectomy.
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Sarrio-Sanz P, Martinez-Cayuelas L, Beltran-Perez A, Muñoz-Montoya M, Segura-Heras JV, Gil-Guillen VF, and Gomez-Perez L
- Abstract
Background/Objectives : The aim was to develop a decision tree and a new prognostic tool to predict cancer-specific survival in patients with urothelial bladder cancer treated with radical cystectomy. Methods : A total of 11,834 patients with bladder cancer treated with radical cystectomy between 2004 and 2019 from the SEER database were randomly split into the derivation ( n = 7889) and validation cohorts ( n = 3945). Survival curves were estimated using conditional decision tree analysis. We used Multiple Imputation by Chained Equations for the treatment of missing values and the pec package to compare the predictive performance. We extracted data from our model following CHARMS and assessed the risk of bias and applicability with PROBAST. Results : A total of 4824 (41%) patients died during the follow-up period due to bladder cancer. A decision tree was made and 12 groups were obtained. Patients with a higher AJCC stage and older age have a worse prognosis. The risk groups were summarized into high, intermediate and low risk. The integrated Brier scores between 0 and 191 months for the bootstrap estimates of the prediction error are the lowest for our conditional survival tree (0.189). The model showed a low risk of bias and low concern about applicability. The results must be externally validated. Conclusions : Decision tree analysis is a useful tool with significant discrimination. With this tool, we were able to stratify patients into 12 subgroups and 3 risk groups with a low risk of bias and low concern about applicability.
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- 2024
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32. Pericoronary Adipose Tissue Radiomics from Coronary Computed Tomography Angiography Identifies Vulnerable Plaques.
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Kim JN, Gomez-Perez L, Zimin VN, Makhlouf MHE, Al-Kindi S, Wilson DL, and Lee J
- Abstract
Pericoronary adipose tissue (PCAT) features on Computed Tomography (CT) have been shown to reflect local inflammation and increased cardiovascular risk. Our goal was to determine whether PCAT radiomics extracted from coronary CT angiography (CCTA) images are associated with intravascular optical coherence tomography (IVOCT)-identified vulnerable-plaque characteristics (e.g., microchannels (MC) and thin-cap fibroatheroma (TCFA)). The CCTA and IVOCT images of 30 lesions from 25 patients were registered. The vessels with vulnerable plaques were identified from the registered IVOCT images. The PCAT-radiomics features were extracted from the CCTA images for the lesion region of interest (PCAT-LOI) and the entire vessel (PCAT-Vessel). We extracted 1356 radiomic features, including intensity (first-order), shape, and texture features. The features were reduced using standard approaches (e.g., high feature correlation). Using stratified three-fold cross-validation with 1000 repeats, we determined the ability of PCAT-radiomics features from CCTA to predict IVOCT vulnerable-plaque characteristics. In the identification of TCFA lesions, the PCAT-LOI and PCAT-Vessel radiomics models performed comparably (Area Under the Curve (AUC) ± standard deviation 0.78 ± 0.13, 0.77 ± 0.14). For the identification of MC lesions, the PCAT-Vessel radiomics model (0.89 ± 0.09) was moderately better associated than the PCAT-LOI model (0.83 ± 0.12). In addition, both the PCAT-LOI and the PCAT-Vessel radiomics model identified coronary vessels thought to be highly vulnerable to a similar standard (i.e., both TCFA and MC; 0.88 ± 0.10, 0.91 ± 0.09). The most favorable radiomic features tended to be those describing the texture and size of the PCAT. The application of PCAT radiomics can identify coronary vessels with TCFA or MC, consistent with IVOCT. Furthermore, the use of CCTA radiomics may improve risk stratification by noninvasively detecting vulnerable-plaque characteristics that are only visible with IVOCT.
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- 2023
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33. Pericoronary adipose tissue radiomics from coronary CT angiography identifies vulnerable plaques characteristics in intravascular OCT.
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Kim JN, Gomez-Perez L, Zimin VN, Makhlouf MHE, Al-Kindi S, Wilson DL, and Lee J
- Abstract
Pericoronary adipose tissue (PCAT) features on CT have been shown to reflect local inflammation, and signals increased cardiovascular risk. Our goal was to determine if PCAT radiomics extracted from coronary CT angiography (CCTA) images are associated with intravascular optical coherence tomography (IVOCT)-identified vulnerable plaque characteristics (e.g., microchannels [MC] and thin-cap fibroatheroma [TCFA]). CCTA and IVOCT images of 30 lesions from 25 patients were registered. Vessels with vulnerable plaques were identified from the registered IVOCT images. PCAT radiomics features were extracted from CCTA images for the lesion region of interest (PCAT-LOI) and the entire vessel (PCAT-Vessel). We extracted 1356 radiomics features, including intensity (first-order), shape, and texture features. Features were reduced using standard approaches (e.g., high feature correlation). Using stratified three-fold cross-validation with 1000 repeats, we determined the ability of PCAT radiomics features from CCTA to predict IVOCT vulnerable plaque characteristics. In identification of TCFA lesions, PCAT-LOI and PCAT-Vessel radiomics models performed comparably (AUC±standard deviation 0.78±0.13, 0.77±0.14). For identification of MC lesions, PCAT-Vessel radiomics model (0.89±0.09) was moderately better associated than that of PCAT-LOI model (0.83±0.12). Both PCAT-LOI and PCAT-Vessel radiomics models also similarly identified coronary vessels thought to be highly vulnerable (i.e., both TCFA and MC) (0.88±0.10, 0.91±0.09). Favorable radiomics features tended to be those describing texture and size of PCAT. PCAT radiomics can identify coronary vessels with TCFA or MC, consistent with IVOCT. CCTA radiomics may improve risk stratification by noninvasively detecting vulnerable plaque characteristics that are only visible with IVOCT.
- Published
- 2023
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34. Automated Segmentation of Microvessels in Intravascular OCT Images Using Deep Learning.
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Lee J, Kim JN, Gomez-Perez L, Gharaibeh Y, Motairek I, Pereira GTR, Zimin VN, Dallan LAP, Hoori A, Al-Kindi S, Guagliumi G, Bezerra HG, and Wilson DL
- Abstract
Microvessels in vascular plaque are associated with plaque progression and are found in plaque rupture and intra-plaque hemorrhage. To analyze this characteristic of vulnerability, we developed an automated deep learning method for detecting microvessels in intravascular optical coherence tomography (IVOCT) images. A total of 8403 IVOCT image frames from 85 lesions and 37 normal segments were analyzed. Manual annotation was performed using a dedicated software (OCTOPUS) previously developed by our group. Data augmentation in the polar ( r , θ ) domain was applied to raw IVOCT images to ensure that microvessels appear at all possible angles. Pre-processing methods included guidewire/shadow detection, lumen segmentation, pixel shifting, and noise reduction. DeepLab v3+ was used to segment microvessel candidates. A bounding box on each candidate was classified as either microvessel or non-microvessel using a shallow convolutional neural network. For better classification, we used data augmentation (i.e., angle rotation) on bounding boxes with a microvessel during network training. Data augmentation and pre-processing steps improved microvessel segmentation performance significantly, yielding a method with Dice of 0.71 ± 0.10 and pixel-wise sensitivity/specificity of 87.7 ± 6.6%/99.8 ± 0.1%. The network for classifying microvessels from candidates performed exceptionally well, with sensitivity of 99.5 ± 0.3%, specificity of 98.8 ± 1.0%, and accuracy of 99.1 ± 0.5%. The classification step eliminated the majority of residual false positives and the Dice coefficient increased from 0.71 to 0.73. In addition, our method produced 698 image frames with microvessels present, compared with 730 from manual analysis, representing a 4.4% difference. When compared with the manual method, the automated method improved microvessel continuity, implying improved segmentation performance. The method will be useful for research purposes as well as potential future treatment planning.
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- 2022
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35. Efficacy, tolerance and predictors of response to the treatment with hyperbaric oxygen therapy for patients with hemorrhagic radiation cystitis.
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Sarrió-Sanz P, Sanchez-Caballero L, Martinez-Cayuelas L, Gori CF, Pacheco-Bru JJ, Nakdali-Kassab B, Gómez-Garberí M, Caballero-Perez P, Gomez-Perez L, and Ortiz-Gorraiz MA
- Subjects
- Hemorrhage therapy, Humans, Retrospective Studies, Treatment Outcome, Cystitis etiology, Cystitis therapy, Hyperbaric Oxygenation methods, Radiation Injuries therapy
- Abstract
Objectives: The aim was to study the efficacy and tolerance in patients with haemorrhagic radiation-induced cystitis (HRC) treated with hyperbaric oxygen therapy (HOT) and analyze which factors were related to the response to the treatment., Material and Methods: We performed a retrospective cohort study of patients treated with HOT for HRC symptoms in a provincial referral centre from 2010 to 2020. We evaluated clinical response to treatment, number of hospitalizations due to HRC and subjective response using the PGI-I questionnaire., Results: We treated 52 patients, with a median of 30 sessions, during 6 months and 40 months (6-68 months) of follow-up. 69.2%of patients responded completely and 21,2% partially. The 53.2% of patients improved before the first 10 sessions. Reduction of hospitalizations/per year due to haematuria from 2.8 to 1.1 (p=0,001). The 73,5% of patients stated that they were "very much better" or "much better" after treatment. During the follow-up, 15.4% of patients had recurrence of HRC. 9.6% of the patients required salvage cystectomy. The patients with a highest RTOG-EORTC scale had more risk to still with symptoms (OR 3.01 (IC95 1.48 - 6.16). All patients were able to complete the proposed treatment plan with good tolerance to HOT., Conclusions: These results show the clinical benefit of HOT in the treatment of HRC, with a reduction of the number of hospitalizations and a subjective improvement.
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- 2022
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36. Mortality Trends Related to Bladder Cancer in Spain, 1999-2018.
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Sarrio-Sanz P, Martinez-Cayuelas L, Gil-Guillen VF, Quesada JA, and Gomez-Perez L
- Abstract
Bladder cancer (BC) is an important cause of premature mortality (PM, <75 years). Spain has one of the highest BC mortality rates in Europe. The objective of this study was to analyse BC mortality trends between 1999 and 2018 in Spain. The study was based on data from the National Institute of Statistics (Instituto Nacional de Estadística-INE). Age-adjusted mortality rates (AAMRs) were calculated by sex and age group. A trend analysis was performed using Joinpoint regression models and years of potential life lost (YPLL). Mortality in men resulting from BC decreased in all age groups studied. This was not observed in women, for whom mortality only decreased in the ≥75 age group. Deaths due to BC occurred prematurely in 38.6% of men and in 23.8% of women, which indicated a greater impact on YPLL in men compared to women. Over the last 20 years, there has been a significant decrease in BC mortality rate, except in women under 75 years of age. Despite this temporal trend of decreasing mortality, BC continues to have a significant impact on YPLL, mainly in men. Given this context, it is important to direct more resources towards prevention and early diagnosis strategies to correct this situation.
- Published
- 2022
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37. Biofilm formation and antibiotic susceptibility in dispersed cells versus planktonic cells from clinical, industry and environmental origins.
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Berlanga M, Gomez-Perez L, and Guerrero R
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- Bacterial Adhesion, Humans, Microbial Sensitivity Tests, Anti-Bacterial Agents pharmacology, Biofilms growth & development, Environmental Microbiology, Plankton drug effects, Plankton physiology
- Abstract
We examined the cell-surface physicochemical properties, the biofilm formation capability and the antibiotic susceptibility in dispersed cells (from an artificial biofilm of alginate beads) and compared with their planktonic (free-swimming) counterparts. The strains used were from different origins, such as clinical (Acinetobacter baumannii AB4), cosmetic industry (Klebsiella oxytoca EU213, Pseudomonas aeruginosa EU190), and environmental (Halomonas venusta MAT28). In general, dispersed cells adhered better to surfaces (measured as the "biofilm index") and had a greater hydrophobicity [measured as the microbial affinity to solvents (MATS)] than planktonic cells. The susceptibility to two antibiotics (ciprofloxacin and tetracycline) of dispersed cells was higher compared with that of their planktonic counterparts (tested by the "bactericidal index"). Dispersed and planktonic cells exhibited differences in cell permeability, especially in efflux pump activity, which could be related to the differences observed in susceptibility to antibiotics. At 1 h of biofilm formation in microtiter plates, dispersed cells treated with therapeutic concentration of ciprofloxacin yielded a lower biofilm index than the control dispersed cells without ciprofloxacin. With respect to the planktonic cells, the biofilm index was similar with and without the ciprofloxacin treatment. In both cases there were a reduction of the number of bacteria measured as viable count of the supernatant. The lower biofilm formation in dispersed cells with ciprofloxacin treatment may be due to a significant increase of biofilm disruption with respect to the biofilm from planktonic cells. From a clinical point of view, biofilms formed on medical devices such as catheters, cells that can be related to an infection were the dispersed cells. Our results showed that early treatment with ciprofloxacin of dispersed cells could diminishe bacterial dispersion and facilitate the partial elimination of the new biofilm formed.
- Published
- 2017
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38. Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.
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Siembab VC, Gomez-Perez L, Rotterman TM, Shneider NA, and Alvarez FJ
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- Animals, Animals, Newborn, Axons metabolism, Calbindins metabolism, DNA-Binding Proteins deficiency, DNA-Binding Proteins genetics, Early Growth Response Protein 3 deficiency, Early Growth Response Protein 3 genetics, Gene Expression Regulation, Developmental genetics, Mice, Mice, Transgenic, Nerve Growth Factors genetics, Nerve Growth Factors metabolism, Parvalbumins metabolism, Phosphopyruvate Hydratase metabolism, Spinal Cord cytology, Synapses genetics, Transcription Factors deficiency, Transcription Factors genetics, Vesicular Glutamate Transport Protein 1 metabolism, Vesicular Glutamate Transport Protein 2 metabolism, Afferent Pathways physiology, Gene Expression Regulation, Developmental physiology, Motor Neurons cytology, Renshaw Cells physiology, Synapses physiology
- Abstract
Motor function in mammalian species depends on the maturation of spinal circuits formed by a large variety of interneurons that regulate motoneuron firing and motor output. Interneuron activity is in turn modulated by the organization of their synaptic inputs, but the principles governing the development of specific synaptic architectures unique to each premotor interneuron are unknown. For example, Renshaw cells receive, at least in the neonate, convergent inputs from sensory afferents (likely Ia) and motor axons, raising the question of whether they interact during Renshaw cell development. In other well-studied neurons, such as Purkinje cells, heterosynaptic competition between inputs from different sources shapes synaptic organization. To examine the possibility that sensory afferents modulate synaptic maturation on developing Renshaw cells, we used three animal models in which afferent inputs in the ventral horn are dramatically reduced (ER81(-/-) knockout), weakened (Egr3(-/-) knockout), or strengthened (mlcNT3(+/-) transgenic). We demonstrate that increasing the strength of sensory inputs on Renshaw cells prevents their deselection and reduces motor axon synaptic density, and, in contrast, absent or diminished sensory afferent inputs correlate with increased densities of motor axons synapses. No effects were observed on other glutamatergic inputs. We conclude that the early strength of Ia synapses influences their maintenance or weakening during later development and that heterosynaptic influences from sensory synapses during early development regulates the density and organization of motor inputs on mature Renshaw cells., (© 2016 Wiley Periodicals, Inc.)
- Published
- 2016
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39. Increasing antibiotic resistance in preservative-tolerant bacterial strains isolated from cosmetic products.
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Orús P, Gomez-Perez L, Leranoz S, and Berlanga M
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- Burkholderia isolation & purification, Humans, Microbial Sensitivity Tests, Preservatives, Pharmaceutical pharmacology, Pseudomonas isolation & purification, Anti-Bacterial Agents pharmacology, Burkholderia drug effects, Cosmetics standards, Drug Resistance, Bacterial, Enterobacter drug effects, Pseudomonas drug effects
- Abstract
To ensure the microbiological quality, consumer safety and organoleptic properties of cosmetic products, manufacturers need to comply with defined standards using several preservatives and disinfectants. A drawback regarding the use of these preservatives is the possibility of generating cross-insusceptibility to other disinfectants or preservatives, as well as cross resistance to antibiotics. Therefore, the objective of this study was to understand the adaptive mechanisms of Enterobacter gergoviae, Pseudomonas putida and Burkholderia cepacia that are involved in recurrent contamination in cosmetic products containing preservatives. Diminished susceptibility to formaldehyde-donors was detected in isolates but not to other preservatives commonly used in the cosmetics industry, although increasing resistance to different antibiotics (β-lactams, quinolones, rifampicin, and tetracycline) was demonstrated in these strains when compared with the wild-type strain. The outer membrane protein modifications and efflux mechanism activities responsible for the resistance trait were evaluated. The development of antibiotic-resistant microorganisms due to the selective pressure from preservatives included in cosmetic products could be a risk for the emergence and spread of bacterial resistance in the environment. Nevertheless, the large contribution of disinfection and preservation cannot be denied in cosmetic products., (Copyright© by the Spanish Society for Microbiology and Institute for Catalan Studies.)
- Published
- 2015
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