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Background: Raw, never stored or pasteurized mother's own milk (MOM) is not always available to feed preterm infants; however, storage and pasteurization of MOM diminishes some bioactive components. It can be difficult to feed raw MOM to preterm infants due to transportation and storage of small volumes that might be pumped away from the infant, and a concern that they might harbor bacteria. However, the higher availability of bioactive components in raw MOM may provide benefits to preterm infants compared to frozen or pasteurized MOM. Research Aim: To systematically review and summarize the results of studies on feeding raw MOM versus frozen or pasteurized MOM to preterm infants born at less than 37 weeks of gestation. Methods: Four databases were searched (Cochrane, Embase, Ovid MEDLINE, and Web of Science) for this systematic review. Of 542 studies identified, nine met inclusion criteria and were critically evaluated using the quality assessment tool for quantitative studies by the Effective Public Health Practice Project. Studies were organized using the Breastfeeding Challenges Facing Preterm Mother–Infant Dyads theoretical framework. Results: Included studies evaluated the outcomes of preterm infants fed raw versus pasteurized MOM (n = 7, 77.8%) or raw versus frozen MOM (n = 2, 22.2%). Researchers found that raw MOM did not increase infant infections and may have improved health and growth outcomes for study participants. Conclusion: There is laboratory evidence supporting the safety and efficacy of the use of raw MOM for preterm infants. A raw MOM diet is recommended for preterm infants by professional organizations. Despite this, it may not be universally prioritized and could require purposeful implementation by each institution. Further research is needed to pursue the potential benefits of a raw MOM diet for preterm infants. [ABSTRACT FROM AUTHOR]

This study compared the effects of emphasizing moral character development or performance character development at three high-performing, high-poverty urban middle schools. Performance character consists of the qualities that allow individuals to regulate their thoughts and actions in ways that support achievement in a particular endeavor. Moral character consists of the qualities relevant to striving for ethical behavior in one's relationships with other individuals and communities. Using a quasi-experimental research design, the authors found that early adolescents attending a school emphasizing moral character development through ethical philosophy programming demonstrated significantly higher levels of integrity over the course of the 2010 to 2011 academic year than their peers at two matched comparison schools ("N" = 544). However, the early adolescents attending the comparison schools--which emphasized performance character development through advisory programming--demonstrated significantly higher levels of perseverance and community connectedness over the course of the academic year. These divergent outcomes across the three schools offer useful implications to educators, researchers, and policy-makers about the different effects of privileging a particular dimension of character education. (Contains 4 tables.)

This mixed-methods study considered the effects of ethical philosophy programming at a high-performing, high-poverty urban high school upon the academic integrity of participating adolescents ("n" = 279). Analyses of pre-post survey data revealed that participating adolescents reported significantly higher levels of academic integrity than their peers at a matched comparison school. Field notes from observations of ethical philosophy lessons and qualitative interviews with participating students revealed that this programming offered students frequent opportunities to practice moral reasoning and introduced philosophical perspectives that influenced students' conception of and commitment to academic integrity. (Contains 2 tables and 3 footnotes.)

Background/Context: Performance character consists of the qualities that allow individuals to regulate their thoughts and actions in ways that support achievement in a particular endeavor. Moral character consists of the qualities relevant to striving for ethical behavior in one's relationships with other individuals and communities. A sizable body of research has demonstrated correlations between student achievement and performance character strengths such as self-discipline, while the relationship between achievement, conduct, and moral character strengths such as integrity is more ambiguous. For both types of character, however, the majority of the extant research literature has focused on relatively small samples of elementary school children, university students, and high-achieving students. Setting: This study took place at three "No Excuses" charter middle schools in a large northeastern city. Charter schools are publicly funded schools that are supervised by state boards of education rather than a local superintendent or school committee. "No Excuses" is a term used to describe high-poverty public schools featuring a strict disciplinary environment, extended school day and year, college preparatory mission, and an intensive focus on traditional reading and mathematics skills. Participants: This study considered the relationship between achievement, conduct, and several character strengths among 488 early adolescents attending three urban charter schools in a large northeastern city. More than 90% of these students identified as African American, Latino, or multi-racial, and two thirds qualified for free or reduced price lunch (a proxy for low socioeconomic status). Research Design: This study combines self-reported survey data on participating students' character strengths with student-level data on grade point average and demerits collected from participants' schools. We fit quantile regression models to consider the relationships between participating students' character strengths, academic achievement, and conduct while controlling for select demographic characteristics. Results: Analyses revealed that students' perseverance, school connectedness and grade level were positive predictors of academic achievement while integrity and demerits were negative predictors of academic achievement. Student conduct was significantly predicted by grade level, grade point average, gender, race/ethnicity and commitment to integrity. In short, both performance and moral character strengths were unique predictors of key student outcomes. Conclusions/Recommendations: In recent years, a number of high-profile charter management organizations have identified cultivating students' performance character as a key lever in promoting student success. Our findings suggest that these organizations would do well to expand their character education programming to include students' moral character strengths as well.

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-[beta] superfamily, which utilize BMP receptors and intracellular SMADs to transduce their signals to regulate cell differentiation, proliferation, and apoptosis. Because mutations in BMP receptor type IA (BMPRIA) and SMAD4 are found in the germline of patients with the colon cancer predisposition syndrome juvenile polyposis, and because the contribution of BMP in colon cancers is largely unknown, we examined colon cancer cells and tissues for evidence of BMP signaling and determined its growth effects. We determined the presence and functionality of BMPR1A by examining BMP-induced phosphorylation and nuclear translocation of SMAD1; transcriptional activity via a BMP-specific luciferase reporter: and growth characteristics by cell cycle analysis, cell growth, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide metabolic assays. These assays were also performed after transfection with a dominant negative (DN) BMPR1A construct. In SMAD4-null SW480 cells, we examined BMP effects on cellular wound assays as well as BMP-induced transcription in the presence of transfected SMAD4. We also determined the expression of BMPR1A, BMP ligands, and phospho-SMAD1 in primary human colon cancer specimens. We found intact BMP signaling and modest growth suppression in HCT116 and two derivative cell lines and, surprisingly, growth suppression in SMAD4-null SW480 cells. BMP-induced SMAD signaling and BMPR1A-mediated growth suppression were reversed with DN BMPR1A transfection. BMP2 slowed wound closure, and transfection of SMAD4 into SW480 cells did not change BMP-specific transcriptional activity over controls due to receptor stimulation by endogenously produced ligand. We found no cell cycle alterations with BMP treatment in the HCT116 and derivative cell lines, but there was an increased [G.sub.1] fraction in SW480 cells that was not due to increased p21 transcription. In human colon cancer specimens, BMP2 and BMP7 ligands, BMPR1A, and phospho-SMAD1 were expressed. In conclusion, BMP signaling is intact and growth suppressive in human colon cancer cells. In addition to SMADs, BMP may utilize SMAD4-independent pathways for growth suppression in colon cancers. transforming growth factor-[beta]; tumor suppressor

ABSTRACT Pathologies of the skull and teeth are well documented for many human populations, but there are fewer studies of other primates. We contrast lesion prevalence and patterning among cercopithecoid primates and map variation onto socioecological variables. We compare craniodental lesions in six species: Nasalis larvatus (n = 54), Colobus polykomos (n = 64), Cercopithecus mitis (n = 65), Macaca fascicularis (n = 109), Theropithecus gelada (n = 13), and Papio anubis (n = 76). One of us (C.A.K.) evaluated each adult skull for multiple lesion types using standard criteria. We also tested for a relationship between lesion prevalence and cranial suture fusion (age proxy). We used nonparametric tests for sex and species differences as well as pathology co‐occurrence in SPSS. Socioecological data come from previous studies. Sex differences in lesion prevalence were only detected in P. anubis. Within taxa, some lesion types co‐occurred. In Macaca, the presence of caries was associated with several other lesion types. Pulp cavity exposure co‐occurred with TMJ osteoarthritis in multiple taxa. Among taxa, male P. anubis had higher lesion prevalences, particularly related to the anterior dentition and facial trauma. Because we did not detect a relationship between suture fusion and lesion prevalence, we propose that craniodental lesions may also be influenced by socioecological variables such as group composition and ratio of fruit to leaves in the diet. Our findings suggest that pain from pulp cavity exposure and related dental infections may alter chewing biomechanics and contribute to onset of TMJ osteoarthritis in nonhuman primates, as seen in humans. Further, we suggest that higher lesion prevalence in male baboons is likely related to male–male competition. Skeletal lesion analysis provides useful insight into primate socioecology, particularly for rare or difficult‐to‐observe phenomena, and provides additional biological context for our own species. [ABSTRACT FROM AUTHOR]