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2. The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging.

Author

Muller GC, Gottlieb MG, Luz Correa B, Gomes Filho I, Moresco RN, and Bauer ME

Subjects
Aged, Aged, 80 and over, C-Reactive Protein metabolism, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes pathology, CD4-Positive T-Lymphocytes virology, CD8-Positive T-Lymphocytes pathology, CD8-Positive T-Lymphocytes virology, Cytomegalovirus immunology, Cytomegalovirus Infections blood, Cytomegalovirus Infections pathology, Cytomegalovirus Infections virology, Female, Glycation End Products, Advanced blood, Glycation End Products, Advanced immunology, Humans, Immunophenotyping, Interleukin-6 blood, Male, Middle Aged, Oxidative Stress immunology, Sex Factors, T-Lymphocyte Subsets pathology, T-Lymphocyte Subsets virology, Thiobarbituric Acid Reactive Substances metabolism, Aging immunology, Antibodies, Viral blood, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Cytomegalovirus Infections immunology, T-Lymphocyte Subsets immunology
Abstract

Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2015
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