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Alaska contains over 600 formerly used defense (FUD) sites, many of which serve as point sources of pollution. These sites are often co-located with rural communities that depend upon traditional subsistence foods, especially lipid-rich animals that bioaccumulate and biomagnify persistent organic pollutants (POPs). Many POPs are carcinogenic and endocrine-disrupting compounds that are associated with adverse health outcomes. Therefore, elevated exposure to POPs from point sources of pollution may contribute to disproportionate incidence of disease in arctic communities. We investigated PCB concentrations and the health implications of POP exposure in sentinel fishes collected near the Northeast Cape FUD site on Sivuqaq (St. Lawrence Island), Alaska. Sivuqaq residents are almost exclusively Yupik and rely on subsistence foods. At the request of the Sivuqaq community, we examined differential gene expression and developmental pathologies associated with exposure to POPs originating at the Northeast Cape FUD site. We found significantly higher levels of PCBs in Alaska blackfish (Dallia pectoralis) collected from contaminated sites downstream of the FUD site compared to fish collected from upstream reference sites. We compared transcriptomic profiles and histopathologies of these same blackfish. Blackfish from contaminated sites overexpressed genes involved in ribosomal and FoxO signaling pathways compared to blackfish from reference sites. Contaminated blackfish also had significantly fewer thyroid follicles and smaller pigmented macrophage aggregates. Conversely, we found that ninespine stickleback (Pungitius pungitius) from contaminated sites exhibited thyroid follicle hyperplasia. Despite our previous research reporting transcriptomic and endocrine differences in stickleback from contaminated vs. reference sites, we did not find significant differences in kidney or gonadal histomorphologies. Our results demonstrate that contaminants from the Northeast Cape FUD site are associated with altered gene expression and thyroid development in native fishes. These results are consistent with our prior work demonstrating disruption of the thyroid hormone axis in Sivuqaq residents., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Environmental pollution causes adverse health effects in many organisms and contributes to health disparities for Arctic communities that depend on subsistence foods, including the Yupik residents of Sivuqaq (St. Lawrence Island), Alaska. Sivuqaq's proximity to Russia made it a strategic location for U.S. military defense sites during the Cold War. Two radar surveillance stations were installed on Sivuqaq, including at the Northeast Cape. High levels of persistent organic pollutants and toxic metals continue to leach from the Northeast Cape formerly used defense (FUD) site despite remediation efforts. We quantified total mercury (Hg) and polychlorinated biphenyl (PCB) concentrations, and carbon and nitrogen stable isotope signatures, in skin and muscle samples from Dolly Varden (Salvelinus malma), an important subsistence species. We found that Hg and PCB concentrations significantly differed across locations, with the highest concentrations found in fish collected near the FUD site. We found that 89% of fish collected from near the FUD site had Hg concentrations that exceeded the U.S. Environmental Protection Agency's (EPA) unlimited Hg-contaminated fish consumption screening level for subsistence fishers (0.049 μg/g). All fish sampled near the FUD site exceeded the EPA's PCB guidelines for cancer risk for unrestricted human consumption (0.0015 μg/g ww). Both Hg and PCB concentrations had a significant negative correlation with δ 13 C when sites receiving input from the FUD site were included in the analysis, but these relationships were insignificant when input sites were excluded. δ 15 N had a significant negative correlation with Hg concentration, but not with PCB concentration. These results suggest that the Northeast Cape FUD site remains a point source of Hg and PCB pollution and contributes to higher concentrations in resident fish, including subsistence species. Moreover, elevated Hg and PCB levels in fish near the FUD site may pose a health risk for Sivuqaq residents., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Objectives: This article synthesizes discussion of collaborative research results, interventions and policy engagement for St Lawrence Island (SLI), Alaska, during the years 2000-2012., Methods: As part of on-going community-based participatory research (CBPR) studies on SLI, 5 discrete exposure-assessment projects were conducted: (a) a biomonitoring study of human blood serum; (b-d) 3 investigations of levels of contaminants in environmental media at an abandoned military site at Northeast Cape--using sediment cores and plants, semi-permeable membrane devices and blackfish, respectively; and (e) a study of traditional foods., Results: Blood serum in residents of SLI showed elevated levels of polychlorinated biphenyls (PCBs) with higher levels among those exposed to the military site at Northeast Cape, an important traditional subsistence-use area. Environmental studies at the military site demonstrated that the site is a continuing source of PCBs to a major watershed, and that clean-up operations at the military site generated PCB-contaminated dust on plants in the region. Important traditional foods eaten by the people of SLI showed elevated concentrations of PCBs, which are primarily derived from the long-range transport of persistent pollutants that are transported by atmospheric and marine currents from more southerly latitudes to the north., Interventions: An important task for all CBPR projects is to conduct intervention strategies as needed in response to research results. Because of the findings of the CBPR projects on SLI, the CBPR team and the people of the Island are actively engaging in interventions to ensure cleanup of the formerly used military sites; reform chemicals policy on a national level; and eliminate persistent pollutants internationally. The goal is to make the Island and other northern/Arctic communities safe for themselves and future generations., Conclusions: As part of the CBPR projects conducted from 2000 to 2012, a series of exposure assessments demonstrate that the leaders of SLI have reason to be concerned about the health of people due to the presence of carcinogenic chemicals as measured in biomonitoring and environmental samples and important traditional foods.

Marine mammals (bowhead whale, walrus, and various seals) constitute the major component of the diet of the Yupik people of St. Lawrence Island, Alaska. St. Lawrence Island residents have higher serum concentrations of polychlorinated biphenyls (PCB) than in the general U.S. population. In order to determine potential sources, traditional food samples were collected from 2004 to 2009 and analyzed for PCBs, three chlorinated pesticides, and seven heavy metals (mercury, copper, zinc, arsenic, selenium, cadmium, and lead). Concentrations of PCB in rendered oils (193-421 ppb) and blubber (73-317 ppb) from all marine mammal samples were at levels that trigger advisories for severely restricted consumption, using U.S. Environmental Protection Agency (EPA) fish consumption advisories. Concentrations of pesticides were lower, but were still elevated. The highest PCB concentrations were found in polar bear (445 ppb) and the lowest in reindeer adipose tissue (2 ppb). Marine mammal and polar bear meat in general have PCB concentrations that were 1-5% of those in rendered oils or adipose tissue. PCB concentrations in organs were higher than meat. Concentrations of metals in oils and meats from all species were relatively low, but increased levels of mercury, cadmium, copper, and zinc were present in some liver and kidney samples. Mercury and arsenic were found in lipid-rich samples, indicating organometals. These results show that the source of the elevated concentrations of these contaminants in the Yupik population is primarily from consumption of marine mammal blubber and rendered oils.

Objectives: To determine serum levels of polychlorinated biphenyls (PCBs) in Siberian Yupik adults from St. Lawrence Island, Alaska, and to determine the relative contribution of atmospheric transport of PCBs and local contamination to body burdens., Study Design: Siberian Yupiks of various ages were recruited from three populations: residents of the village of Gambell, residents of the village of Savoonga who did not have family hunting camps near the Northeast Cape (NEC), a Formerly Used Defense Site (FUDS) known to be contaminated with PCBs, and residents of Savoonga whose families had a hunting camp at the NEC., Methods: Levels of PCBs were measured in serum samples from 130 people, ages 19-76. These Alaska Natives follow a traditional diet high in marine mammals and fish, which bioconcentrate organochlorine compounds that migrate to the Arctic via global air transport and ocean currents., Results: The lipid-adjusted serum PCB levels of those members of families with hunting camps at the NEC had a mean lipid-adjusted PCB concentration of 1,143 ppb, whereas other residents of Savoonga had values of 847 ppb and residents of Gambell had values of 785 ppb., Conclusions: Our observations suggest that atmospheric transport of PCBs contributes to levels in the Yupik people, but that the abandoned military site at the NEC may also contribute to the human body burden in those individuals who have either spent substantial time or consumed food from there.