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34 results on '"Golinelli, Giulia"'

1. Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma

Author

Chiavelli, Chiara, Prapa, Malvina, Rovesti, Giulia, Silingardi, Marco, Neri, Giovanni, Pugliese, Giuseppe, Trudu, Lucia, Dall’Ora, Massimiliano, Golinelli, Giulia, Grisendi, Giulia, Vinet, Jonathan, Bestagno, Marco, Spano, Carlotta, Papapietro, Roberto Vito, Depenni, Roberta, Di Emidio, Katia, Pasetto, Anna, Nascimento Silva, Daniela, Feletti, Alberto, Berlucchi, Silvia, Iaccarino, Corrado, Pavesi, Giacomo, and Dominici, Massimo

Published
2024
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3. GD2 CAR T cells against human glioblastoma

Author

Prapa, Malvina, Chiavelli, Chiara, Golinelli, Giulia, Grisendi, Giulia, Bestagno, Marco, Di Tinco, Rosanna, Dall’Ora, Massimiliano, Neri, Giovanni, Candini, Olivia, Spano, Carlotta, Petrachi, Tiziana, Bertoni, Laura, Carnevale, Gianluca, Pugliese, Giuseppe, Depenni, Roberta, Feletti, Alberto, Iaccarino, Corrado, Pavesi, Giacomo, and Dominici, Massimo

Published
2021
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4. 261 Synergistic antitumor effects of mouse mesothelin-directed CAR (mmeso-CAR) T cells and αCD40 in a syngeneic model of PDAC

Author

Golinelli, Giulia, primary, Fan, Ting-Jia, additional, Gabunia, Khatuna, additional, Reff, Jordan, additional, Mai, David, additional, Johnson, Omar, additional, Ferraro, Zachary, additional, Song, Decheng, additional, Gupta, Aasha, additional, Deshmukh, Mansi, additional, Assenmacher, Charles-Antoine, additional, Radaelli, Enrico, additional, Martinez, Daniel, additional, Rech, Andrew, additional, Fraietta, Joseph A, additional, Xu, He N, additional, Wilson, Wesley V, additional, Tchou, Julia C, additional, Levine, Bruce L, additional, Young, Regina M, additional, Scholler, John, additional, and June, Carl H, additional

Published
2023
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7. Soluble TRAIL Armed Human MSC As Gene Therapy For Pancreatic Cancer

Author

Spano, Carlotta, Grisendi, Giulia, Golinelli, Giulia, Rossignoli, Filippo, Prapa, Malvina, Bestagno, Marco, Candini, Olivia, Petrachi, Tiziana, Recchia, Alessandra, Miselli, Francesca, Rovesti, Giulia, Orsi, Giulia, Maiorana, Antonino, Manni, Paola, Veronesi, Elena, Piccinno, Maria Serena, Murgia, Alba, Pinelli, Massimo, Horwitz, Edwin M., Cascinu, Stefano, Conte, Pierfranco, and Dominici, Massimo

Published
2019
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8. Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo

Author

Corsi, Martina, primary, Paghi, Alessandro, additional, Mariani, Stefano, additional, Golinelli, Giulia, additional, Debrassi, Aline, additional, Egri, Gabriella, additional, Leo, Giuseppina, additional, Vandini, Eleonora, additional, Vilella, Antonietta, additional, Dähne, Lars, additional, Giuliani, Daniela, additional, and Barillaro, Giuseppe, additional

Published
2022
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10. Anti-GD2 CAR MSCs against metastatic Ewing's sarcoma

Author

Golinelli, Giulia, primary, Grisendi, Giulia, additional, Dall'Ora, Massimiliano, additional, Casari, Giulia, additional, Spano, Carlotta, additional, Talami, Rebecca, additional, Banchelli, Federico, additional, Prapa, Malvina, additional, Chiavelli, Chiara, additional, Rossignoli, Filippo, additional, Candini, Olivia, additional, D'Amico, Roberto, additional, Nasi, Milena, additional, Cossarizza, Andrea, additional, Casarini, Livio, additional, and Dominici, Massimo, additional

Published
2022
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11. The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma

Author

Avnet, Sofia, primary, Lemma, Silvia, additional, Cortini, Margherita, additional, Di Pompo, Gemma, additional, Perut, Francesca, additional, Lipreri, Maria Veronica, additional, Roncuzzi, Laura, additional, Columbaro, Marta, additional, Errani, Costantino, additional, Longhi, Alessandra, additional, Zini, Nicoletta, additional, Heymann, Dominique, additional, Dominici, Massimo, additional, Grisendi, Giulia, additional, Golinelli, Giulia, additional, Consolino, Lorena, additional, Longo, Dario Livio, additional, Nanni, Cristina, additional, Righi, Alberto, additional, and Baldini, Nicola, additional

Published
2021
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12. Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?

Author

Golinelli, Giulia, primary, Mastrolia, Ilenia, additional, Aramini, Beatrice, additional, Masciale, Valentina, additional, Pinelli, Massimo, additional, Pacchioni, Lucrezia, additional, Casari, Giulia, additional, Dall’Ora, Massimiliano, additional, Soares, Milena Botelho Pereira, additional, Damasceno, Patrícia Kauanna Fonseca, additional, Silva, Daniela Nascimento, additional, Dominici, Massimo, additional, and Grisendi, Giulia, additional

Published
2020
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13. Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine

Author

Damasceno, Patricia Kauanna Fonseca, primary, de Santana, Thaís Alves, additional, Santos, Girlaine Café, additional, Orge, Iasmim Diniz, additional, Silva, Daniela Nascimento, additional, Albuquerque, Juliana Fonseca, additional, Golinelli, Giulia, additional, Grisendi, Giulia, additional, Pinelli, Massimo, additional, Ribeiro dos Santos, Ricardo, additional, Dominici, Massimo, additional, and Soares, Milena Botelho Pereira, additional

Published
2020
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15. Adipose mesenchymal stromal/stem cells expanded by a GMP compatible protocol displayed improved adhesion on cancer cells in flow conditions

Author

Agostini, Francesco, primary, Vicinanza, Carla, additional, Cintio, Federica Di, additional, Battiston, Monica, additional, Lombardi, Elisabetta, additional, Golinelli, Giulia, additional, Durante, Cristina, additional, Toffoli, Giuseppe, additional, Dominici, Massimo, additional, and Mazzucato, Mario, additional

Published
2020
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17. MSC-Delivered Soluble TRAIL and Paclitaxel as Novel Combinatory Treatment for Pancreatic Adenocarcinoma

Author

Rossignoli, Filippo, primary, Spano, Carlotta, additional, Grisendi, Giulia, additional, Foppiani, Elisabetta Manuela, additional, Golinelli, Giulia, additional, Mastrolia, Ilenia, additional, Bestagno, Marco, additional, Candini, Olivia, additional, Petrachi, Tiziana, additional, Recchia, Alessandra, additional, Miselli, Francesca, additional, Rovesti, Giulia, additional, Orsi, Giulia, additional, Veronesi, Elena, additional, Medici, Gregorio, additional, Petocchi, Benedetta, additional, Pinelli, Massimo, additional, Horwitz, Edwin M., additional, Conte, Pierfranco, additional, and Dominici, Massimo, additional

Published
2019
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18. Targeting GD2-positive glioblastoma by chimeric antigen receptor empowered mesenchymal progenitors

Author

Golinelli, Giulia, primary, Grisendi, Giulia, additional, Prapa, Malvina, additional, Bestagno, Marco, additional, Spano, Carlotta, additional, Rossignoli, Filippo, additional, Bambi, Franco, additional, Sardi, Iacopo, additional, Cellini, Monica, additional, Horwitz, Edwin M., additional, Feletti, Alberto, additional, Pavesi, Giacomo, additional, and Dominici, Massimo, additional

Published
2018
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20. Additional file 4: of Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

Author

D’Souza, Naomi, Rossignoli, Filippo, Golinelli, Giulia, Grisendi, Giulia, Spano, Carlotta, Candini, Olivia, Osturu, Satoru, Catani, Fabio, Paolucci, Paolo, Horwitz, Edwin, and Dominici, Massimo

Abstract

Link 4.1 Overview of the main pre-clinical findings on the impact of wild-type MSC in liver diseases. Link 4.2 Overview of the main pre-clinical findings on the impact of gene-modified MSC in liver diseases. (DOCX 22 kb)

Published
2015
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21. Additional file 1: of Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

Author

D’Souza, Naomi, Rossignoli, Filippo, Golinelli, Giulia, Grisendi, Giulia, Spano, Carlotta, Candini, Olivia, Osturu, Satoru, Catani, Fabio, Paolucci, Paolo, Horwitz, Edwin, and Dominici, Massimo

Abstract

Link 1.1 Overview of the main experimental findings on the impact of wild-type MSC in diseases associated with the central and peripheral nervous system. Link 1.2 Overview of the main experimental findings on the impact of gene-modified MSC in diseases associated with the central and peripheral nervous system. (DOCX 34 kb)

Published
2015
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22. Additional file 7: of Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

Author

D’Souza, Naomi, Rossignoli, Filippo, Golinelli, Giulia, Grisendi, Giulia, Spano, Carlotta, Candini, Olivia, Osturu, Satoru, Catani, Fabio, Paolucci, Paolo, Horwitz, Edwin, and Dominici, Massimo

Abstract

Link 7.1 Overview of the main pre-clinical findings on the impact of wild-type MSC in skeletal diseases. Link 7.2 Overview of the main pre-clinical findings on the impact of gene-modified MSC in skeletal diseases. (DOCX 24 kb)

Published
2015
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23. Additional file 6: of Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

Author

D’Souza, Naomi, Rossignoli, Filippo, Golinelli, Giulia, Grisendi, Giulia, Spano, Carlotta, Candini, Olivia, Osturu, Satoru, Catani, Fabio, Paolucci, Paolo, Horwitz, Edwin, and Dominici, Massimo

Abstract

Link 6.1 Overview of the main pre-clinical findings on the impact of wild-type MSC in renal diseases. Link 6.2 Overview of the main pre-clinical findings on the impact of gene-modified MSC in renal diseases. (DOCX 29 kb)

Published
2015
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24. Additional file 5: of Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

Author

D’Souza, Naomi, Rossignoli, Filippo, Golinelli, Giulia, Grisendi, Giulia, Spano, Carlotta, Candini, Olivia, Osturu, Satoru, Catani, Fabio, Paolucci, Paolo, Horwitz, Edwin, and Dominici, Massimo

Abstract

Link 5.1 Overview of the main pre-clinical findings on the impact of wild-type MSC in pancreatic diseases. Link 5.2 Overview of the main pre-clinical findings on the impact of gene-modified MSC in pancreatic diseases. (DOCX 20 kb)

Published
2015
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25. Additional file 2: of Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

Author

D’Souza, Naomi, Rossignoli, Filippo, Golinelli, Giulia, Grisendi, Giulia, Spano, Carlotta, Candini, Olivia, Osturu, Satoru, Catani, Fabio, Paolucci, Paolo, Horwitz, Edwin, and Dominici, Massimo

Abstract

Link 2.1 Overview of the main pre-clinical findings on the impact of wild-type MSC in heart diseases. Link 2.2 Overview of the main pre-clinical findings on the impact of gene-modified MSC in heart diseases. (DOCX 39 kb)

Published
2015
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26. Additional file 3: of Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

Author

D’Souza, Naomi, Rossignoli, Filippo, Golinelli, Giulia, Grisendi, Giulia, Spano, Carlotta, Candini, Olivia, Osturu, Satoru, Catani, Fabio, Paolucci, Paolo, Horwitz, Edwin, and Dominici, Massimo

Abstract

Link 3.1 Overview of the main pre-clinical findings on the impact of wild-type MSC in lung diseases. Link 3.2 Overview of the main pre-clinical findings on the impact of gene-modified MSC in lung diseases. (DOCX 24 kb)

Published
2015
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28. Tumor Stroma Manipulation By MSC

Author

Grisendi, Giulia, primary, Spano, Carlotta, additional, Rossignoli, Filippo, additional, D';souza, Naomi, additional, Golinelli, Giulia, additional, Fiori, Agnese, additional, M Horwitz, Edwin, additional, Guarneri, Valentina, additional, Piacentini, Federico, additional, Paolucci, Paolo, additional, and Dominici, Massimo, additional

Published
2016
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32. Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies.

Author

D'souza, Naomi, Rossignoli, Filippo, Golinelli, Giulia, Grisendi, Giulia, Spano, Carlotta, Candini, Olivia, Osturu, Satoru, Catani, Fabio, Paolucci, Paolo, Horwitz, Edwin M., and Dominici, Massimo

Subjects
MESENCHYMAL stem cells, GENE therapy, STROMAL cells, CELLULAR therapy, BIOMOLECULES
Abstract

Regenerative medicine relying on cell and gene therapies is one of the most promising approaches to repair tissues. Multipotent mesenchymal stem/stromal cells (MSC), a population of progenitors committing into mesoderm lineages, are progressively demonstrating therapeutic capabilities far beyond their differentiation capacities. The mechanisms by which MSC exert these actions include the release of biomolecules with anti-inflammatory, immunomodulating, anti-fibrogenic, and trophic functions. While we expect the spectra of these molecules with a therapeutic profile to progressively expand, several human pathological conditions have begun to benefit from these biomolecule-delivering properties. In addition, MSC have also been proposed to vehicle genes capable of further empowering these functions. This review deals with the therapeutic properties of MSC, focusing on their ability to secrete naturally produced or gene-induced factors that can be used in the treatment of kidney, lung, heart, liver, pancreas, nervous system, and skeletal diseases. We specifically focus on the different modalities by which MSC can exert these functions. We aim to provide an updated understanding of these paracrine mechanisms as a prerequisite to broadening the therapeutic potential and clinical impact of MSC. [ABSTRACT FROM AUTHOR]

Published
2015
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33. Anti-GD2 CAR MSCs Against Metastatic Ewing's Sarcoma

Author

Golinelli, Giulia, Grisendi, Giulia, Dall'Ora, Massimiliano, Casari, Giulia, Spano, Carlotta, Talami, Rebecca, Banchelli, Federico, Prapa, Malvina, Chiavelli, Chiara, Rossignoli, Filippo, Candini, Olivia, D'Amico, Roberto, Nasi, Milena, Cossarizza, Andrea, Casarini, Livio, and Dominici, Massimo

Abstract

•Ewing's sarcoma mortality due to metastases remains unacceptably high•The ganglioside GD2 is a potential cell surface target for cell-based approaches•Bi-functional MSCs express a soluble variant of TRAIL together with an anti-GD2 CAR•Bi-functional MSCs are able to counteract tumour growth in the lungs•The anti-GD2 CAR ameliorates tumour targeting and persistence of bi-functional MSCs

Published
2021
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34. Soluble TRAIL Armed Human MSC As Gene Therapy For Pancreatic Cancer

Author

Tiziana Petrachi, Malvina Prapa, Giulia Orsi, Olivia Candini, Marco Bestagno, Antonino Maiorana, Edwin M. Horwitz, Giulia Grisendi, Giulia Golinelli, Massimo Pinelli, Alba Murgia, Massimo Dominici, Pierfranco Conte, Giulia Rovesti, Elena Veronesi, Stefano Cascinu, Maria Serena Piccinno, Francesca Miselli, Paola Manni, Filippo Rossignoli, Alessandra Recchia, Carlotta Spano, Spano, Carlotta, Grisendi, Giulia, Golinelli, Giulia, Rossignoli, Filippo, Prapa, Malvina, Bestagno, Marco, Candini, Olivia, Petrachi, Tiziana, Recchia, Alessandra, Miselli, Francesca, Rovesti, Giulia, Orsi, Giulia, Maiorana, Antonino, Manni, Paola, Veronesi, Elena, Piccinno, Maria Serena, Murgia, Alba, Pinelli, Massimo, Horwitz, Edwin M., Cascinu, Stefano, Conte, Pierfranco, and Dominici, Massimo

Subjects
0301 basic medicine, Stromal cell, endocrine system diseases, Genetic enhancement, pancreatic cancer, lcsh:Medicine, Adipose tissue, Apoptosis, TRAIL, Adenocarcinoma, Article, TNF-Related Apoptosis-Inducing Ligand, MSC, Mice, 03 medical and health sciences, 0302 clinical medicine, Pancreatic cancer, Carcinoma, medicine, Animals, Humans, lcsh:Science, TRAIL, pancreatic cancer, gene therapy, MSC, Multidisciplinary, business.industry, lcsh:R, Mesenchymal stem cell, Mesenchymal Stem Cells, Genetic Therapy, medicine.disease, Xenograft Model Antitumor Assays, gene therapy, digestive system diseases, Pancreatic Neoplasms, Receptors, TNF-Related Apoptosis-Inducing Ligand, 030104 developmental biology, Cancer research, lcsh:Q, Stem cell, business, 030217 neurology & neurosurgery, Carcinoma, Pancreatic Ductal
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive adult cancers with an unacceptable prognosis. For this reason novel therapies accounting for PDAC peculiarities, such as the relevant stromal reaction, are urgently needed. Here adipose mesenchymal stromal/stem cells (AD-MSC) have been armed to constantly release a soluble trimeric and multimeric variant of the known anti-cancer TNF-related apoptosis-inducing ligand (sTRAIL). This cancer gene therapy strategy was in vitro challenged demonstrating that sTRAIL was thermally stable and able to induce apoptosis in the PDAC lines BxPC-3, MIA PaCa-2 and against primary PDAC cells. sTRAIL released by AD-MSC relocated into the tumor stroma was able to significantly counteract tumor growth in vivo with a significant reduction in tumor size, in cytokeratin-7+ cells and by an anti-angiogenic effect. In parallel, histology on PDAC specimens form patients (n = 19) was performed to investigate the levels of TRAIL DR4, DR5 and OPG receptors generating promising insights on the possible clinical translation of our approach. These results indicate that adipose MSC can very efficiently vehicle a novel TRAIL variant opening unexplored opportunities for PDAC treatment.

Published
2019

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