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2. Secondary Prevention and Extreme Cardiovascular Risk Evaluation (SEVERE-1), Focus on Prevalence and Associated Risk Factors: The Study Protocol

Author

Maloberti, A, Intravaia, R, Mancusi, C, Cesaro, A, Golia, E, Ilaria, F, Coletta, S, Merlini, P, De Chiara, B, Bernasconi, D, Algeri, M, Ossola, P, Ciampi, C, Riccio, A, Tognola, C, Ardissino, M, Inglese, E, Scaglione, F, Calabro, P, De Luca, N, Giannattasio, C, Maloberti A., Intravaia R. C. M., Mancusi C., Cesaro A., Golia E., Ilaria F., Coletta S., Merlini P., De Chiara B., Bernasconi D., Algeri M., Ossola P., Ciampi C., Riccio A., Tognola C., Ardissino M., Inglese E., Scaglione F., Calabro P., De Luca N., Giannattasio C., Maloberti, A, Intravaia, R, Mancusi, C, Cesaro, A, Golia, E, Ilaria, F, Coletta, S, Merlini, P, De Chiara, B, Bernasconi, D, Algeri, M, Ossola, P, Ciampi, C, Riccio, A, Tognola, C, Ardissino, M, Inglese, E, Scaglione, F, Calabro, P, De Luca, N, Giannattasio, C, Maloberti A., Intravaia R. C. M., Mancusi C., Cesaro A., Golia E., Ilaria F., Coletta S., Merlini P., De Chiara B., Bernasconi D., Algeri M., Ossola P., Ciampi C., Riccio A., Tognola C., Ardissino M., Inglese E., Scaglione F., Calabro P., De Luca N., and Giannattasio C.

Abstract

Introduction: Despite significant improvement in secondary CardioVascular (CV) preventive strategies, some acute and chronic coronary syndrome (ACS and CCS) patients will suffer recurrent events (also called “extreme CV risk”). Recently new biochemical markers, such as uric acid (UA), lipoprotein A [Lp(a)] and several markers of inflammation, have been described to be associated with CV events recurrence. The SEcondary preVention and Extreme cardiovascular Risk Evaluation (SEVERE-1) study will accurately characterize extreme CV risk patients enrolled in cardiac rehabilitation (CR) programs. Aim. Our aims will be to describe the prevalence of extreme CV risk and its association with newly described biochemical CV risk factors. Aim: Our aims will be to describe the prevalence of extreme CV risk and its association with newly described biochemical CV risk factors. Methods: We will prospectively enrol 730 ACS/CCS patients at the beginning of a CR program. Extreme CV risk will be retrospectively defined as the presence of a previous (within 2 years) CV events in the patients’ clinical history. UA, Lp(a) and inflammatory markers (interleukin-6 and -18, tumor necrosis factor alpha, C-reactive protein, calprotectin and osteoprotegerin) will be assessed in ACS/CCS patients with extreme CV risk and compared with those without extreme CV risk but also with two control groups: 1180 hypertensives and 765 healthy subjects. The association between these biomarkers and extreme CV risk will be assessed with a multivariable model and two scoring systems will be created for an accurate identification of extreme CV risk patients. The first one will use only clinical variables while the second one will introduce the biochemical markers. Finally, by exome sequencing we will both evaluate polygenic risk score ability to predict recurrent events and perform mendellian randomization analysis on CV biomarkers. Conclusions: Our study proposal was granted by the European Union PNRR M6/C2 call.

Published
2023

3. Preliminary investigation of the use of Silybum marianum(L.) Gaertn. as a Cd accumulator in contaminated Mediterranean soils: the relationships among cadmium (Cd) soil fractions and plant Cd content

Author

Papadimou, S. G., Barbayiannis, Ν., and Golia, E. E.

Abstract

The plant Silybum marianum(L.) Gaertn. has been used in a preliminary study to investigate its phytoremediation potential in moderately and heavily Cd-polluted Greek soils. For this purpose, a pot experiment was carried out using four soil treatments, two from agricultural and two from urban areas, contaminated with 3 and 30 mg of Cd per kg of soil. The modified Bureau of Community Reference (BCR) fractionation method was used to determine Cd levels in the soil fractions. The water-soluble, available-DTPA extractable, total and pseudo-total concentrations of Cd were also evaluated and attempts to find relationships between Cd soil fractions and Cd levels in the parts of the cultivated plants were made. Significant correlations among Cd soil fractions, Cd plant parts, and soil physicochemical parameters were obtained and discussed. High Cd translocation and accumulation rates were observed mainly in the root and the lower part of the stems, while in flowers and seeds no Cd was detected, leading to the conclusion that the high-value product contained in the seeds maintains its quality and is free of contaminants. The results are satisfactory indicating Silybum marianum(L.) Gaertn. as a promising plant for remediation practices in Cd-contaminated Mediterranean soils, promoting the principles of circular economy.

Published
2024
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12. Prevention of atherothrombotic events in patients with diabetes mellitus: from antithrombotic therapies to new-generation glucose-lowering drugs

Author

Patti, G., Cavallari, I., Andreotti, F., Calabrò, P., Cirillo, P., Denas, G., Galli, M., Golia, E., Maddaloni, E., Marcucci, R., Parato, V. M., Pengo, V., Prisco, D., Ricottini, E., Renda, G., Santilli, F., Simeone, P., De Caterina, R., on behalf of the Working Group on Thrombosis of the Italian Society of Cardiology, Patti, Giuseppe, Cavallari, Ilaria, Andreotti, Felicita, Calabrò, Paolo, Cirillo, Plinio, Denas, Gentian, Galli, Mattia, Golia, Enrica, Maddaloni, Ernesto, Marcucci, Rossella, Parato, Vito Maurizio, Pengo, Vittorio, Prisco, Domenico, Ricottini, Elisabetta, Renda, Giulia, Santilli, Francesca, Simeone, Paola, and De Caterina, Raffaele

Subjects
0301 basic medicine, diabetes, thrombosis, cardiovascular events, antithrombotic drugs, medicine.medical_specialty, Disease, 030204 cardiovascular system & hematology, blood coagulation, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Risk Factors, Diabetes mellitus, Antithrombotic, Diabetes Mellitus, Secondary Prevention, medicine, Humans, Hypoglycemic Agents, atherothrombotic events, diabetes mellitus, prevention, glucose-lowering drugs, Risk factor, Intensive care medicine, Diabetes, Cardiovascular Disease, Thrombosis, Preventive medicine, business.industry, Consensus Statement, Thrombosis, Type 2 diabetes, Atrial fibrillation, Guideline, medicine.disease, Type 1 diabetes, 030104 developmental biology, Cardiovascular Diseases, Practice Guidelines as Topic, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Drug therapy, Cardiology and Cardiovascular Medicine, business
Abstract

Diabetes mellitus is an important risk factor for a first cardiovascular event and for worse outcomes after a cardiovascular event has occurred. This situation might be caused, at least in part, by the prothrombotic status observed in patients with diabetes. Therefore, contemporary antithrombotic strategies, including more potent agents or drug combinations, might provide greater clinical benefit in patients with diabetes than in those without diabetes. In this Consensus Statement, our Working Group explores the mechanisms of platelet and coagulation activity, the current debate on antiplatelet therapy in primary cardiovascular disease prevention, and the benefit of various antithrombotic approaches in secondary prevention of cardiovascular disease in patients with diabetes. While acknowledging that current data are often derived from underpowered, observational studies or subgroup analyses of larger trials, we propose antithrombotic strategies for patients with diabetes in various cardiovascular settings (primary prevention, stable coronary artery disease, acute coronary syndromes, ischaemic stroke and transient ischaemic attack, peripheral artery disease, atrial fibrillation, and venous thromboembolism). Finally, we summarize the improvements in cardiovascular outcomes observed with the latest glucose-lowering drugs, and on the basis of the available evidence, we expand and integrate current guideline recommendations on antithrombotic strategies in patients with diabetes for both primary and secondary prevention of cardiovascular disease., Patients with diabetes mellitus have a prothrombotic status that increases the risk of cardiovascular events and worsens prognosis after these events. In this Consensus Statement, the Working Group on Thrombosis of the Italian Society of Cardiology proposes antithrombotic strategies for patients with diabetes in various cardiovascular settings.

Published
2019

13. Prevention of atherothrombotic events in patients with diabetes mellitus: from antithrombotic therapies to new-generation glucose-lowering drugs

Author

Patti, G, Cavallari, I, Andreotti, Felicita, Calabro, P, Cirillo, P, Denas, G, Galli, Mattia, Golia, E, Maddaloni, E, Marcucci, R, Parato, Vm, Pengo, V, Prisco, D, Ricottini, E, Renda, G, Santilli, F, Simeone, P, De Caterina, R, Andreotti, F (ORCID:0000-0002-1456-6430), Galli, M, Patti, G, Cavallari, I, Andreotti, Felicita, Calabro, P, Cirillo, P, Denas, G, Galli, Mattia, Golia, E, Maddaloni, E, Marcucci, R, Parato, Vm, Pengo, V, Prisco, D, Ricottini, E, Renda, G, Santilli, F, Simeone, P, De Caterina, R, Andreotti, F (ORCID:0000-0002-1456-6430), and Galli, M

Abstract

Diabetes mellitus is an important risk factor for a first cardiovascular event and for worse outcomes after a cardiovascular event has occurred. This situation might be caused, at least in part, by the prothrombotic status observed in patients with diabetes. Therefore, contemporary antithrombotic strategies, including more potent agents or drug combinations, might provide greater clinical benefit in patients with diabetes than in those without diabetes. In this Consensus Statement, our Working Group explores the mechanisms of platelet and coagulation activity, the current debate on antiplatelet therapy in primary cardiovascular disease prevention, and the benefit of various antithrombotic approaches in secondary prevention of cardiovascular disease in patients with diabetes. While acknowledging that current data are often derived from underpowered, observational studies or subgroup analyses of larger trials, we propose antithrombotic strategies for patients with diabetes in various cardiovascular settings (primary prevention, stable coronary artery disease, acute coronary syndromes, ischaemic stroke and transient ischaemic attack, peripheral artery disease, atrial fibrillation, and venous thromboembolism). Finally, we summarize the improvements in cardiovascular outcomes observed with the latest glucose-lowering drugs, and on the basis of the available evidence, we expand and integrate current guideline recommendations on antithrombotic strategies in patients with diabetes for both primary and secondary prevention of cardiovascular disease.

Published
2019

15. Evaluation of soil properties, irrigation and solid waste application levels on Cu and Zn uptake by industrial hemp.

Author

Golia, E. E., Angelaki, A., Giannoulis, K. D., Skoufogianni, E., Bartzialis, D., Cavalaris, Ch., and Vleioras, S.

Subjects
*SOLID waste, *SODIC soils, *WASTE treatment, *IRRIGATION, *ACID soils
Abstract

A three-year experiment was performed to study the alteration of copper and zinc levels in industrial hemp grown in different soils using elevated sewage slurry solid waste applications. Two soil samples, an acidic and an alkaline one, with different soil properties, such as percentage of CaCO3 and cation exchange capacity values, were used. Three treatments of waste solid with provided elevated concentrations of Cu and Zn were combined with two irrigation levels. The application of high doses of the solid residue as well as high irrigation level lead to an increase of the mobility of metals in hemp leaves in acidic soil in contrast to alkaline. On the contrary, in alkaline soil along with a reduced irrigation level, there is a decrease in the mobility of Cu and therefore its accumulation in the roots or stems was observed. Concluding, hemp seem to be a promising plant remediator, after the application of the proper irrigation level and taking into account the physico-chemical soil properties of moderately contaminated (with copper and zinc) soils. [ABSTRACT FROM AUTHOR]

Published
2021
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16. SPONTANEOUS CORONARY ARTERY DISSECTION PRESENTING AS ACUTE MYOCARDIAL INFARCTION IN A MIDDLE–AGED MAN: WHAT YOU WOULDN’T EXPECT

Author

Roma, A, Tontodonato, M, Golia, E, Coletta, S, Ianniciello, A, Mercone, G, Limatola, M, Rucco, M, Pariggiano, I, and Calabrò, P

Abstract

Spontaneous coronary artery dissection (SCAD) is a rare cause of acute non atherothrombotic coronary syndrome. It predominantly affects female sex. Both diagnosis and therapeutic decision–making are challenging due to its unpredictable course and recurrence rate. We describe a case of a 50y old man with chest pain(CP), referred to our cathlab for primary percutaneous coronary intervention(PCI) through the Emergency Medical Service, with an anterior ST–segment elevation myocardial infarction(STEMI) detected on ECG. A type 2b SCAD starting from the Left Main(LM) involving proximal Left Anterior Descending (LAD) artery and circumflex artery(Cx) was detected. PCI with Drug–Eluting Stent(DES) implantation on LM and proximal LAD was deemed necessary due to ongoing ischemia and LM involvement. IntraVascular UltraSound(IVUS) on LAD and LM showed good stent deployment and confirmed a non–obstructive SCAD of Cx,left untreated. Patient was started with dual antiplatelet therapy and after 5 days in our cardiac intensive care unit(ICU) he was moved to cardiology unit. Few hours later he had recurrence of CP and an Inferior STEMI was detected. A progression of SCAD of the Cx with critical flow limitation in its proximal tract was found at coronary angiography. Then PCI with DES release was performed using a T and Small Protrusion technique on LM–LAD–Cx and cutting–balloon was used to fenestrate intima with a successful drainage of the intramural hematoma (IH) in the distal portion. Our case represents an uncommon presentation of SCAD, as STEMI involving a male patient. In a recent large cohort of SCAD patients only 10% were men. Male SCAD patients are younger, have less frequently prior MI, depression, emotional stress triggers and are less likely to have associated fibromuscular dysplasia. More often they report physical stress triggers and a more subtle clinical presentation. Conservative management remains the mainstay of treatment in the absence of ongoing ischemia, hemodynamic instability, or LM involvement. When PCI is indicated, it is often associated with an unfavorable course (difficult wiring of the lesion, propagation, and potential milking of the IH along the vessel).Cutting balloon technique has been increasingly used in the interventional approach to SCAD. Several questions remain unanswered about appropriate antithrombotic regimen, duration of ICU observation and the opportunity to perform coronary imaging to review the disease prior to a safe discharge.

Published
2024
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17. Role of percutaneous transcatheter embolization (PTE) in the treatment of spontaneous bleeding associated with anticoagulant therapy

Author

Ierardi AM, Floridi C, Pellegrino C, Petrillo M, Pinto A, Iadevito I, Golia E, Perillo A, ROTONDO, Antonio, Carrafiello G., GRASSI, Roberto, Ierardi, Am, Floridi, C, Pellegrino, C, Petrillo, M, Pinto, A, Iadevito, I, Golia, E, Perillo, A, Grassi, Roberto, Rotondo, Antonio, and Carrafiello, G.

Subjects
spontaneous bleeding, anticoagulant therapy, percutaneous transcatheter embolization
Abstract

To evaluate safety and clinical efficacy of percutaneous transcatheter embolization (PTE) in the treatment of spontaneous bleedings (SBs) in patients submitted to chronic anticoagulation therapy. MATERIALS AND METHODS: From January 2007 to December 2012, 20 patients (mean age 75.8 years, range 68-91 years) with 23 SBs were retrospectively evaluated. Active bleeding was documented by contrast enhanced-multidetector row computed tomography (CE-MDCT). PTE was performed using different embolic agents. Technical success (TS), clinical success (CS), late success (LS) and mortality rate (M) related to the angiographic procedure and complications were evaluated. RESULTS: CE-MDCT and digital subtraction angiography (DSA) identified active bleeding sites in 18 cases (18/20). In two cases (2/20) DSA did not confirm the arterial bleeding diagnosed on CE-MDCT. Twenty-three sessions of PTE were performed. TS, CS, LS and M were, respectively, 100, 85, 15 and 0 %. No major complications were observed. CONCLUSIONS: PTE could be considered a safe and effective "first line" approach to treat SB associated with anticoagulation therap

Published
2014

18. Platelet function and long-term antiplatelet therapy in women: is there a gender-specificity? A 'state-of-the-art' paper

Author

Patti, G, DE CATERINA, Raffaele, Abbate, R, Andreotti, F, Biasucci, L. M, Calabrò, P, Cioni, G, Davi', Giovanni, Di Sciascio, G, Golia, E, Golino, P, Malatesta, G, Mangiacapra, F, Marcucci, R, Nusca, A, Parato, V. M, Pengo, V, Prisco, D, Pulcinelli, F, Renda, Giulia, Ricottini, E, Ruggieri, B, Santilli, Francesca, Sofi, F, Zimarino, M, Working Group on Thrombosis of the Italian Society of Cardiology, Patti, G, De Caterina, R, Abbate, R, Andreotti, F, Biasucci, Lm, Calabro', Paolo, Cioni, G, Davì, G, Di Sciascio, G, Golia, E, Golino, Paolo, Malatesta, G, Mangiacapra, F, Marcucci, R, Nusca, A, Parato, Vm, Pengo, V, Prisco, D, Pulcinelli, F, Renda, G, Ricottini, E, Ruggieri, B, Santilli, F, Sofi, F, and Zimarino, M.

Subjects
Blood Platelets, Male, Platelets, medicine.medical_specialty, Post hoc, Platelet Function Tests, Pregnancy Complications, Cardiovascular, Hemorrhage, Body size, Risk Assessment, Cost of Illness, Pregnancy, Risk Factors, Medicine, Humans, Gender differences, Platelet, Women, Intensive care medicine, Secondary prevention, Aspirin, Sex Characteristics, business.industry, Antiplatelet therapy, gender differences, platelets, antiplatelet therapy, men, thrombosis, women, Men, Thrombosis, medicine.disease, Stroke, Multiple factors, Treatment Outcome, Cardiovascular Diseases, Physical therapy, Observational study, Drug Therapy, Combination, Female, Cardiology and Cardiovascular Medicine, business, Diabetic Angiopathies, Platelet Aggregation Inhibitors, medicine.drug
Abstract

Although the female gender is generally less represented in cardiovascular studies, observational and randomized investigations suggest that-compared with men-women may obtain different benefits from antiplatelet therapy. Multiple factors, including hormonal mechanisms and differences in platelet biology, might contribute to such apparent gender peculiarities. The thrombotic and bleeding risks, as well as outcomes after a cardiovascular event, appear to differ between genders, partly in relation to differences in age, comorbidities and body size. Equally, the benefits of antiplatelet therapy may differ in women compared with men in different vascular beds, during primary or secondary prevention and according to the type of an antiplatelet agent used. This document is an attempt to bring together current evidence, clinical practices and gaps of knowledge on gender-specific platelet function and antiplatelet therapy. On the basis of the available data, we provide suggestions on current indications of antiplatelet therapy for cardiovascular prevention in women with different clinical features; no strong recommendation may be given because the available data derive from observational studies or post hoc/subgroup analyses of randomized studies without systematic adjustments for baseline risk profiles.

Published
2014

19. Right Heart Structural and Functional Remodeling in Athletes

Author

D'Andrea A, La Gerche A, Golia E, Teske A. J., Bossone E, RUSSO, Maria Giovanna, CALABRO', Raffaele, Baggish A. L., D'Andrea, A, La Gerche, A, Golia, E, Teske, A. J., Bossone, E, Russo, Maria Giovanna, Calabro', Raffaele, and Baggish, A. L.

Published
2014

22. Right ventricular morphology and function in top level athletes: a 3-dimensional echocardiographic study

Author

D'Andrea A, Riegler L, Morra S, Scarafile R, Salerno G, Cocchia R, Golia E, Martone F, LIMONGELLI, Giuseppe, Pacileo G, Bossone E, Calabrò R, RUSSO, Maria Giovanna, DI SALVO, Giovanni, D'Andrea, A, Riegler, L, Morra, S, Scarafile, R, Salerno, G, Cocchia, R, Golia, E, Martone, F, DI SALVO, Giovanni, Limongelli, Giuseppe, Pacileo, G, Bossone, E, Calabrò, R, and Russo, Maria Giovanna

Abstract

BACKGROUND: Our objective was to explore the right ventricular (RV) dimensions and function and the effect of long-term intensive training in a large population of top level athletes using real-time three-dimensional (3D) echocardiography. METHODS: A total of 430 top-level athletes (220 endurance-trained athletes [ETAs] and 210 strength-trained athletes; 265 men [61.6%]; mean age 27.4 ± 10.1 years, range 18-40) and 250 healthy controls underwent a transthoracic echocardiographic examination. Three-dimensional RV measurements included serial short-axis reconstructions of the RV volumetric data sets, and the RV endocardial contour was traced with cross-reference to the long-axis images for identification of the tricuspid annulus. The end-diastolic and end-systolic RV volumes and ejection fraction were calculated off-line using the method of the summation of discs. RESULTS: The strength-trained athletes had a greater heart rate, body surface area, and systolic blood pressure at rest than the ETAs and controls. All RV diameters and 3D volumes and all transmitral and transtricuspid Doppler indexes were greater in the ETAs. Also, the left ventricular stroke volume, cardiac index, and pulmonary artery systolic pressure were greater in the ETAs, and all two-dimensional and 3D RV systolic indexes were comparable. On univariate analysis, the 3D RV end-diastolic volume was significantly associated with advanced age, male gender, duration of training, endurance training, increased left ventricular stroke volume, and pulmonary artery systolic pressure. On multivariate analysis, in the overall study population, the type and duration of training (P < .01), pulmonary artery systolic pressure (P < .01), and left ventricular stroke volume (P < .001) were the only independent predictors of RV end-diastolic volume. CONCLUSIONS: The results of the present study have delineated the upper limits of the RV dimensions in highly trained athletes as measured by real-time 3D echocardiography. The RV end-diastolic volume was significantly greater in the ETA than in the strength-trained athletes and controls.

Published
2012

23. Contemporary evidence of coronary atherosclerotic disease and myocardial bridge on left anterior descending artery in a patient with a nonobstructive hypertrophic cardiomyopathy

Author

CALABRO', Paolo, LIMONGELLI, Giuseppe, Bianchi R, Caprile M, Bigazzi MC, Sordelli C, Palmieri R, D’Alessandro R, Golia E, Pacileo G, Calabrò R., Calabro', Paolo, Bianchi, R, Caprile, M, Bigazzi, Mc, Sordelli, C, Palmieri, R, D’Alessandro, R, Golia, E, Limongelli, Giuseppe, Pacileo, G, and Calabrò, R.

Published
2011

24. Related citations 18.Left ventricular myocardial velocities and deformation indexes in top-level athletes

Author

D'ANDREA A, COCCHIA R, RIEGLER L, SCARAFILE R, SALERNO G, GRAVINO R, GOLIA E, PEZZULLO E, CITRO R, LIMONGELLI, Giuseppe, PACILEO G, CUOMO S, CASO P, BOSSONE E, CALABRÒ R., RUSSO, Maria Giovanna, D'Andrea, A, Cocchia, R, Riegler, L, Scarafile, R, Salerno, G, Gravino, R, Golia, E, Pezzullo, E, Citro, R, Limongelli, Giuseppe, Pacileo, G, Cuomo, S, Caso, P, Russo, Maria Giovanna, Bossone, E, and Calabrò, R.

Published
2010

27. Poster session V * Saturday 11 December 2010, 08:30-12:30

Author

Pham, Q. H., primary, Von Lueder, T. G., additional, Namtvedt, S. K., additional, Rosjo, H., additional, Omland, T., additional, Steine, K., additional, Timoteo, A. T., additional, Mota Carmo, M., additional, Simoes, M., additional, Branco, L. M., additional, Ferreira, R. C., additional, Kato, R., additional, Ito, J., additional, Tahara, T., additional, Yokoyama, Y., additional, Ashikaga, T., additional, Satoh, Y., additional, Na, J. O., additional, Hong, H. E., additional, Kim, M. N., additional, Shin, S. Y., additional, Choi, C. U., additional, Kim, E. J., additional, Rha, S. W., additional, Park, C. G., additional, Seo, H. S., additional, Oh, D. J., additional, Ticulescu, R., additional, Brigido, S., additional, Vriz, O., additional, Sparacino, L., additional, Popescu, B. A., additional, Ginghina, C., additional, Carerj, S., additional, Nicolosi, G. L., additional, Antonini-Canterin, F., additional, Onaindia Gandarias, J. J., additional, Romero, A., additional, Laraudogoitia, E., additional, Velasco, S., additional, Quintana, O., additional, Cacicedo, A., additional, Rodriguez, I., additional, Alarcon, J. A., additional, Gonzalez, J., additional, Lekuona, I., additional, Subinas, A., additional, Abdula, G., additional, Lund, L. H., additional, Winter, R., additional, Brodin, L., additional, Sahlen, A., additional, Masaki, M., additional, Cha, Y. M., additional, Yuasa, T., additional, Dong, K., additional, Dong, Y. X., additional, Mankad, S. V., additional, Oh, J. K., additional, Vallet, F., additional, Lequeux, B., additional, Diakov, C., additional, Sosner, P., additional, Christiaens, L., additional, Coisne, D., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Uchida, K., additional, Ueyama, T., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Cho, E. J., additional, Choi, K. Y., additional, Kwon, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Cho, J. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Cikes, M., additional, Bijnens, B., additional, Velagic, V., additional, Kopjar, T., additional, Milicic, D., additional, Biocina, B., additional, Gasparovic, H., additional, Almuntaser, I., additional, Brown, A., additional, Foley, B., additional, Mulvihill, N., additional, Crean, P., additional, King, G., additional, Murphy, R., additional, Takata, Y., additional, Taniguchi, M., additional, Nobusada, S., additional, Sugawara, M., additional, Toh, N., additional, Kusano, K., additional, Itoh, H., additional, Wellnhofer, E., additional, Kriatselis, C., additional, Nedios, S., additional, Gerds-Li, J. H., additional, Fleck, E., additional, Poulsen, M. K., additional, Henriksen, J. E., additional, Dahl, J., additional, Johansen, A., additional, Haghfelt, T., additional, Hoilund-Carlsen, P. F., additional, Beck-Nielsen, H., additional, Moller, J. E., additional, Dankowski, R., additional, Wierzchowiecki, M., additional, Michalski, M., additional, Nowicka, A., additional, Szymanowska, K., additional, Pajak, A., additional, Poprawski, K., additional, Szyszka, A., additional, Kasner, M., additional, Westermann, D., additional, Schultheiss, H. P., additional, Tschoepe, C., additional, Watanabe, T., additional, Iwai-Takano, M., additional, Kobayashi, A., additional, Machii, H., additional, Takeishi, Y., additional, Paelinck, B. P., additional, Van Herck, P. L., additional, Bosmans, J. M., additional, Vrints, C. J., additional, Lamb, H. J., additional, Doltra, A., additional, Vidal, B., additional, Silva, E., additional, Poyatos, S., additional, Mont, L., additional, Berruezo, A., additional, Castel, A., additional, Tolosana, J. M., additional, Brugada, J., additional, Sitges, M., additional, Dencker, M., additional, Bjorgell, O., additional, Hlebowicz, J., additional, Szelenyi, Z. S., additional, Szenasi, G., additional, Kiss, M., additional, Prohaszka, Z., additional, Patocs, A., additional, Karadi, I., additional, Vereckei, A., additional, Saha, S. K., additional, Anderson, P. L., additional, Govind, S., additional, Govindan, M., additional, Moggridge, J. C., additional, Kiotsekoglou, A., additional, Gopal, A. S., additional, Loegstrup, B. B., additional, Christophersen, T. B., additional, Hoefsten, D. E., additional, Moeller, J. E., additional, Boetker, H. E., additional, Egstrup, K., additional, Graefe, M., additional, Huang, F. Q., additional, Zhang, R. S., additional, Le, T. T., additional, Tan, R. S., additional, Sattarzadeh Badkoubeh, R., additional, Tavoosi, A., additional, Elahian, A. R., additional, Drapkina, O., additional, Ivashkin, V. I., additional, Fazakas, A., additional, Pepo, L., additional, Janosi, O., additional, Kopitovic, I., additional, Goncalves, A., additional, Marcos-Alberca, P., additional, Almeria, C., additional, Feltes, G., additional, Rodriguez, E., additional, Garcia, E., additional, Hernandez-Antolin, R., additional, Macaya, C., additional, Silva Cardoso, J., additional, Zamorano, J. L., additional, Navarro, M. S., additional, Valentin, M., additional, Banes, C. M., additional, Rigo, F., additional, Grolla, E., additional, Tona, F., additional, Cuaia, V., additional, Moreo, A., additional, Badano, L., additional, Raviele, A., additional, Iliceto, S., additional, Tarzia, P., additional, Sestito, A., additional, Nerla, R., additional, Di Monaco, A., additional, Infusino, F., additional, Matera, D., additional, Greco, F., additional, Tacchino, R. M., additional, Lanza, G. A., additional, Crea, F., additional, Nemes, A., additional, Balazs, E., additional, Pinter, K. S., additional, Egyed, A., additional, Csanady, M., additional, Forster, T., additional, Holte, E., additional, Vegsundvag, J., additional, Hole, T., additional, Hegbom, K., additional, Wiseth, R., additional, Sharif, D., additional, Sharif-Rasslan, A., additional, Shahla, C., additional, Khalil, A., additional, Rosenschein, U., additional, Zagatina, A., additional, Zhuravskaya, N., additional, Tyurina, T. 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A., additional, Natali, R., additional, Garramone, B., additional, Savino, M., additional, Lotrionte, M., additional, Sonaglioni, A., additional, Loperfido, F., additional, Zdravkovic, M., additional, Perunicic, J., additional, Krotin, M., additional, Ristic, M., additional, Vukomanovic, V., additional, Zaja, M., additional, Radovanovic, S., additional, Saric, J., additional, Zdravkovic, D., additional, Cotrim, C., additional, Almeida, A. R., additional, Miranda, R., additional, Almeida, A. G., additional, Picano, E., additional, Carrageta, M., additional, D'andrea, A., additional, Cocchia, R., additional, Riegler, L., additional, Golia, E., additional, Scarafile, R., additional, Caso, P., additional, Russo, M. G., additional, Bossone, E., additional, Calabro', R., additional, Noman, H., additional, Adel, A., additional, Elfaramawy, A. M. R., additional, Abdelraouf, M., additional, Elnaggar, W. A. E. L., additional, Baligh, E., additional, Sargento, L., additional, Silva, D., additional, Goncalves, S., additional, Ribeiro, S., additional, Vinhas Sousa, G., additional, Almeida, A., additional, Lopes, M., additional, Rodriguez-Manero, M., additional, Aguado Gil, L., additional, Azcarate, P., additional, Lloret Luna, P., additional, Macias Gallego, A., additional, Castano, S. A. R. A., additional, Garcia, M., additional, Pujol Salvador, C., additional, Barba, J., additional, Redondo, P., additional, Tomasoni, L., additional, Sitia, S., additional, Atzeni, F., additional, Gianturco, L., additional, Ricci, C., additional, Sarzi-Puttini, P., additional, Turiel, M., additional, De Gennaro Colonna, V., additional, Uejima, T., additional, Jaroch, J., additional, Polombo, C., additional, Hughes, A., additional, Vinereanu, D., additional, Evanvelista, A., additional, Leftheriotis, G., additional, Fraser, A. G., additional, Lewczuk, A., additional, Sobkowicz, B., additional, Tomaszuk-Kazberuk, A., additional, Sawicki, R., additional, Hirnle, T., additional, Michalski, B. W., additional, Filipiak, D., additional, Kasprzak, J. D., additional, Lipiec, P., additional, Dalen, H., additional, Mjolstad, O. C., additional, Klykken, B. E., additional, Graven, T., additional, Martensson, M., additional, Olsson, M., additional, Brodin, L.-A., additional, Enache, R., additional, Leiballi, E., additional, Penhall, A., additional, Perry, R., additional, Altman, M., additional, Sinhal, A., additional, Bennetts, J., additional, Chew, D. P., additional, Joseph, M. X., additional, Larsen, L. H., additional, Kristensen, T., additional, Kober, L. V., additional, Kofoed, K. F., additional, Moscoso Costa, F., additional, Ribeiras, R., additional, Brito, J., additional, Boshoff, S., additional, Neves, J., additional, Teles, R., additional, Canada, M., additional, Andrade, M. J., additional, Gouveia, R., additional, Silva, A., additional, Miskovic, A., additional, Poerner, T. P., additional, Stiller, C. S., additional, Goebel, B. G., additional, Moritz, A. M., additional, Stefani, L., additional, Galanti, G. G., additional, Moraldo, M., additional, Bergamini, C., additional, Pabari, P. A., additional, Dhutia, N. M., additional, Malaweera, A. S. N., additional, Willson, K., additional, Davies, J., additional, Hughes, A. D., additional, Xu, X. Y., additional, Francis, D. P., additional, Jasaityte, R., additional, Amundsen, B., additional, Barbosa, D., additional, Loeckx, D., additional, Kiss, G., additional, Orderud, F., additional, Robesyn, V., additional, Claus, P., additional, D'hooge, J., additional, Nao, T., additional, Miura, T., additional, Shams, K., additional, Samir, S., additional, Samir, R., additional, El-Sayed, M., additional, Anwar, A. M., additional, Nosir, Y., additional, Galal, A., additional, Chamsi-Pasha, H., additional, Ciobanu, A., additional, Dulgheru, R., additional, Bennett, S., additional, De Luca, A., additional, Toncelli, L., additional, Cappelli, F., additional, Cappelli, B., additional, Vono, M. C. R., additional, Galanti, G., additional, Zorman, Y., additional, Yilmazer, M. S., additional, Akyildiz, M., additional, Gurol, T., additional, Aydin, A., additional, Dagdeviren, B., additional, and Kalangos, A., additional

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2010
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28. Poster session III * Friday 10 December 2010, 08:30-12:30

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Guldbrand, D., primary, Goetzsche, O., additional, Eika, B., additional, Watanabe, N., additional, Taniguchi, M., additional, Akagi, T., additional, Koide, N., additional, Sano, S., additional, Orbovic, B., additional, Obrenovic-Kircanski, B., additional, Ristic, S., additional, Soskic, L. J., additional, Alhabshan, F., additional, Jijeh, A., additional, Abo Remsh, H., additional, Alkhaldi, A., additional, Najm, H. K., additional, Gasior, Z., additional, Skowerski, M., additional, Kulach, A., additional, Szymanski, L., additional, Sosnowski, M., additional, Wang, M., additional, Siu, C. W., additional, Lee, K., additional, Yue, W. S., additional, Yan, G. H., additional, Lee, S., additional, Lau, C. P., additional, Tse, H. F., additional, O'connor, K., additional, Rosca, M., additional, Magne, J., additional, Romano, G., additional, Moonen, M., additional, Pierard, L. A., additional, Lancellotti, P., additional, Floria, M., additional, De Roy, L., additional, Blommaert, D., additional, Jamart, J., additional, Dormal, F., additional, Lacrosse, M., additional, Arsenescu Georgescu, C., additional, Mizariene, V., additional, Bucyte, S., additional, Bertasiute, A., additional, Pociute, E., additional, Zaliaduonyte-Peksiene, D., additional, Baronaite-Dudoniene, K., additional, Sileikiene, R., additional, Vaskelyte, J., additional, Jurkevicius, R., additional, Dencker, M., additional, Thorsson, O., additional, Karlsson, M. K., additional, Linden, C., additional, Wollmer, P., additional, Andersen, L. B., additional, Catalano, O., additional, Perotti, M. R., additional, Colombo, E., additional, De Giorgi, M., additional, Cattaneo, M., additional, Cobelli, F., additional, Priori, S. G., additional, Ober, C., additional, Iancu Adrian, I. A., additional, Andreea Parv, P. A., additional, Cadis Horatiu, C. H., additional, Ober Mihai, O. M., additional, Chmielecki, M., additional, Fijalkowski, M., additional, Galaska, R., additional, Dubaniewicz, W., additional, Lewicki, L., additional, Targonski, R., additional, Ciecwierz, D., additional, Puchalski, W., additional, Koprowski, A., additional, Rynkiewicz, A., additional, Hristova, K., additional, La Gerche, A., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Kempny, A., additional, Diller, G. P., additional, Orwat, S., additional, Kaleschke, G., additional, Kerckhoff, G., additional, Schmidt, R., additional, Radke, R. M., additional, Baumgartner, H., additional, Smarz, K., additional, Zaborska, B., additional, Jaxa-Chamiec, T., additional, Maciejewski, P., additional, Budaj, A., additional, Kiotsekoglou, A., additional, Govind, S. C., additional, Gadiyaram, V., additional, Moggridge, J. C., additional, Govindan, M., additional, Gopal, A. S., additional, Ramesh, S. S., additional, Brodin, L. A., additional, Saha, S. K., additional, Ramzy, I. S., additional, Lindqvist, P., additional, Lam, Y. Y., additional, Duncan, A. M., additional, Henein, M. Y., additional, Craciunescu, I. S., additional, Serban, M., additional, Iancu, M., additional, Revnic, C., additional, Popescu, B. A., additional, Alexandru, D., additional, Rogoz, D., additional, Uscatescu, V., additional, Ginghina, C., additional, Careri, G., additional, Di Monaco, A., additional, Nerla, R., additional, Tarzia, P., additional, Lamendola, P., additional, Sestito, A., additional, Lanza, G. 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T., additional, Truong, S., additional, Manlhiot, C., additional, Mertens, L., additional, Baroni, M., additional, Mariani, M., additional, Chabane, H. K., additional, Berti, S., additional, Ripoli, A., additional, Storti, S., additional, Glauber, M., additional, Scopelliti, P. A., additional, Antongiovanni, G. B., additional, Personeni, D., additional, Saino, A., additional, Tespili, M., additional, Jung, P., additional, Mueller, M., additional, Jander, F., additional, Sohn, H. Y., additional, Rieber, J., additional, Schneider, P., additional, Klauss, V., additional, Agricola, E., additional, Slavich, M., additional, Stella, S., additional, Ancona, M., additional, Oppizzi, M., additional, Bertoglio, L., additional, Melissano, G., additional, Margonato, A., additional, Chiesa, R., additional, Cejudo Diaz Del Campo, L., additional, Mesa Rubio, D., additional, Ruiz Ortiz, M., additional, Delgado Ortega, M., additional, Villanueva Fernandez, E., additional, Lopez Aguilera, J., additional, Toledano Delgado, F., additional, Pan Alvarez-Ossorio, M., additional, Suarez De Lezo Cruz Conde, J., additional, Lafuente, M., additional, Butz, T., additional, Meissner, A., additional, Lang, C. N., additional, Prull, M. W., additional, Plehn, G., additional, Trappe, H. J., additional, Nair, S. V., additional, Lee, L., additional, Mcleod, I., additional, Whyte, G., additional, Shrimpton, J., additional, Hildick Smith, D., additional, James, P. 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C., additional, Abdel Ghani, B., additional, Schiavina, R., additional, Salvade, P., additional, Morganti, A., additional, Bedogni, F., additional, Mahia, P., additional, Gutierrez, L., additional, Pineda, V., additional, Garcia, B., additional, Otaegui, I., additional, Rodriguez, J. F., additional, Gonzalez, M. T., additional, Descalzo, M., additional, Evangelista, A., additional, Garcia-Dorado, D., additional, Bruin De- Bon, H. A. C. M., additional, Van Den Brink, R. B. A., additional, Surie, S., additional, Bresser, P., additional, Vleugels, J., additional, Eckmann, H. M., additional, Samson, D. A., additional, Bouma, B. 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M., additional, Sieders, A., additional, Lamb, H., additional, Ajmone Marsan, N., additional, Westenberg, J., additional, De Roos, A., additional, Schuijf, J. D., additional, Bax, J. J., additional, Anwar, A. M., additional, Nosir, Y., additional, Chamsi-Pasha, H., additional, Tschernich, H. D., additional, Seeburger, J., additional, Borger, M., additional, Mukherjee, C., additional, Mohr, F. W., additional, Ender, J., additional, Obase, K., additional, Okura, H., additional, Yamada, R., additional, Miyamoto, Y., additional, Saito, K., additional, Imai, K., additional, Hayashida, A., additional, and Yoshida, K., additional

Published
2010
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29. Right ventricular myocardial involvement in either physiological or pathological left ventricular hypertrophy: an ultrasound speckle-tracking two-dimensional strain analysis

Author

D'Andrea, A., primary, Caso, P., additional, Bossone, E., additional, Scarafile, R., additional, Riegler, L., additional, Di Salvo, G., additional, Gravino, R., additional, Cocchia, R., additional, Castaldo, F., additional, Salerno, G., additional, Golia, E., additional, Limongelli, G., additional, De Corato, G., additional, Cuomo, S., additional, Pacileo, G., additional, Russo, M. G., additional, and Calabro, R., additional

Published
2010
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38. Physiologic and pathophysiologic changes in the right heart in highly trained athletes.

Author

D'Andrea, A., La Gerche, A., Golia, E., Padalino, R., Calabrò, R., Russo, M.G., and Bossone, E.

Abstract

Copyright of Herz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015
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41. [The role of natriuretic peptides in heart failure]

Author

Ancona R, LIMONGELLI, Giuseppe, Pacileo G, Miele T, Rea A, Roselli T, Masarone D, Messina S, Palmieri R, Golia E, Iacomino M, Gala S, CALABRO', Paolo, DI SALVO, Giovanni, CALABRO', Raffaele, Ancona, R, Limongelli, Giuseppe, Pacileo, G, Miele, T, Rea, A, Roselli, T, Masarone, D, Messina, S, Palmieri, R, Golia, E, Iacomino, M, Gala, S, Calabro', Paolo, DI SALVO, Giovanni, and Calabro', Raffaele

Subjects
Heart Failure, Ventricular Dysfunction, Left, Natriuretic Peptide, Brain, Humans, Natriuretic Peptide, C-Type, Prognosis, Atrial Natriuretic Factor, Biomarkers
Abstract

Over the last decades, there has been a significant increase in incidence and prevalence of heart failure, a major cause of cardiac morbidity and mortality. Measurements of neurohormones, in particular B-type natriuretic peptide (BNP), can significantly improve diagnostic accuracy, and also correlate with long-term morbidity and mortality in patients with chronic heart failure presenting to the emergency department. BNP is secreted by cardiac ventricles mainly in response to wall stress and neurohormonal factors like the sympathetic nervous system, endothelins, and the rennin-angiotensin-aldosterone system. BNP increases myocardial relaxation and oppose the vasoconstrictive, sodium retaining, and natriuretic effects caused by vasoconstrictive factors. BNP is the first biomarker to prove its clinical value for the diagnosis of left ventricular systolic and diastolic dysfunction but also for the right ventricular dysfunction, guiding prognosis and therapy management. Emerging clinical data will help further refine biomarker-guided therapeutic and monitoring strategies involving BNP.

44. Range of right heart measurements in top-level athletes: the training impact

Author

Giovanni Di Salvo, Raffaella Scarafile, Maria Giovanna Russo, Pio Caso, Luigi Nunziata, Enrica Pezzullo, Lucia Riegler, Rosangela Cocchia, Sergio Cuomo, Enrica Golia, Raffaele Calabrò, Antonello D'Andrea, Gemma Salerno, Rodolfo Citro, Eduardo Bossone, Antonio Cittadini, D'Andrea, A., Riegler, L., Golia, E., Cocchia, R., Salerno, G., Pezzullo, E., Nunziata, L., Citro, R., Cuomo, S., Caso, P., DI Salvo, G., Cittadini, Antonio, Russo, M. G., Calabro', R., Bossone, E., D'Andrea, A, Riegler, L, Golia, E, Cocchia, R, Scarafile, R, Salerno, G, Pezzullo, E, Nunziata, L, Citro, R, Cuomo, S, Caso, P, DI SALVO, Giovanni, Cittadini, A, Russo, Maria Giovanna, and Calabro', Raffaele

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Physiological, Physical exercise, Doppler echocardiography, Athlete's heart, Endurance, Pulmonary pressure, Right atrium, Right ventricle, Adaptation, Physiological, Athletes, Echocardiography, Female, Heart, Humans, Young Adult, Exercise, Physical Endurance, Sports, right atrium, medicine.artery, Internal medicine, medicine, Adaptation, Body surface area, endurance, medicine.diagnostic_test, business.industry, Stroke volume, medicine.anatomical_structure, Blood pressure, Pulmonary artery, Ventricular pressure, Vascular resistance, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Objectives: To explore the full range of right heart dimensions and the impact of long-term intensive training in athletes. Background: Although echocardiography has been widely used to distinguish the athlete's heart from pathologic left ventricular (LV) hypertrophy, only few reports have described right ventricular (RV) and right atrial (RA) adaptations to extensive physical exercise. Methods: 650 top-level athletes [395 endurance-(ATE) and 255 strength-trained (ATS); 410 males (63.1%); mean age 28.4 +/- 10.1; 18-40 years] and 230 healthy age-and sex-comparable controls underwent a transthoracic echocardiographic exam. Along with left heart parameters, right heart measurements included: RV end-diastolic diameters at the basal and mid-cavity level; RV base-to-apex length; RV proximal and distal outflow tract diameters; RA long and short diameters; and RA area. Tricuspid annular plane systolic excursion and RV tissue Doppler systolic peak velocity were assessed as indexes of RV systolic function. Pulmonary artery systolic pressure (PASP) was estimated from the peak tricuspid regurgitant velocity. Results: ATS showed increased sum of wall thickness and relative wall thickness, whereas left atrial volume, LV end-diastolic volume, LV stroke volume and PASP were significantly higher in ATE. RV and RA measurements were all significantly greater in ATE than in ATS and controls. ATE also showed improved early diastolic RV function, whereas RV systolic indexes were comparable among groups. On multivariate analysis, type and duration of training (p

Published
2011

45. Right Ventricular Changes in Highly Trained Athletes: Between Physiology and Pathophysiology

Author

Antonello D'Andrea, Eduardo Bossone, Rosangela Cocchia, Raffaele Calabrò, Enrica Pezzullo, Lucia Riegler, Enrica Golia, Agostino Mattera Iacono, Raffaella Scarafile, Maria Giovanna Russo, Alberto Morello, D'Andrea, A, Morello, A, Iacono, Am, Scarafile, R, Cocchia, R, Riegler, L, Pezzullo, E, Golia, E, Bossone, E, Calabro, R, and Russo, Mg

Subjects
Cardiac function curve, medicine.medical_specialty, sport training, Cardiomyopathy, Athletes heart, Review Article, strain, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, skin and connective tissue diseases, right heart, Sport training, biology, business.industry, Athletes, Doppler, medicine.disease, biology.organism_classification, Pathophysiology, medicine.anatomical_structure, Ventricle, exercise-induced cardiomyopathy, Right heart, Cardiology, sense organs, Cardiology and Cardiovascular Medicine, business
Abstract

Several studies have described the adaptive remodeling of the heart during exercise. In some more practiced endurance athletes, there is a disproportionate load on the right ventricle (RV), at least during exercise, and this might be the basis for a chronic pro-arrhythmic RV remodeling. Especially, in these kinds of athletes the recovery after detraining might be incomplete, in particular for RV changes. The observation of acute myocardial injury based on transient elevation of biomarkers and chronic myocardial scar, not completely reversible changes of the RV and an increased prevalence of some arrhythmias support the existence of an "exercise-induced cardiomyopathy." The aim of this paper is to review current knowledge about changes in the right heart in highly trained athletes and how these change influence cardiac function.

Published
2015

46. Right Heart Structural and Functional Remodeling in Athletes

Author

Enrica Golia, Eduardo Bossone, Maria Giovanna Russo, Arco J. Teske, Antonello D'Andrea, Raffaele Calabrò, Andre La Gerche, Aaron L. Baggish, D'Andrea, A, La Gerche, A, Golia, E, Teske, Aj, Bossone, E, Russo, Mg, Calabro, R, and Baggish, Al

Subjects
Male, medicine.medical_specialty, Heart Ventricles, Athlete's heart, right ventricle, Ventricular Function, Left, strain imaging, Internal medicine, athlete's heart, medicine, Humans, echocardiography, Radiology, Nuclear Medicine and imaging, Medicine(all), Physical Education and Training, Ventricular Remodeling, exercise, tissue Doppler, biology, business.industry, Athletes, Strain imaging, Stroke Volume, Color doppler, Functional recovery, biology.organism_classification, Adaptation, Physiological, Echocardiography, Doppler, Color, Review article, Radiology Nuclear Medicine and imaging, Right heart, Physical Endurance, Ventricular Function, Right, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Sports
Abstract

Long-term intensive exercise training programs lead to numerous progressive cardiac adaptations, which are collectively termed "athlete's heart." Noninvasive diagnostic techniques, such as color Doppler echocardiography, have been widely used in the analysis of the athlete's heart. Initial experiences focused mainly on left heart adaptations to training. However, in recent years, substantial structural and functional adaptations of the right heart have been documented. The present review article focuses on recent data defining right heart adaptation to short- and long-term periods of exercise training. Right ventricular (RV) morphology and function may be more profoundly affected by intense exercise and, in some cases, functional recovery may be incomplete. Moreover, there is speculation that such changes may represent a substrate for proarrhythmic RV remodeling in some highly trained athletes, even in the absence of a known familial redisposition.

Published
2014
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47. Radial Versus Femoral Access for Coronary Angiography

Author

Mario Crisci, Paolo Calabrò, Enrica Golia, Calabro, P., Golia, E., and Crisci, M.

Subjects
Coronary angiography, China, medicine.medical_specialty, Acute coronary syndrome, Vascular access, vascular acce, 030204 cardiovascular system & hematology, acute coronary syndrome, 03 medical and health sciences, Percutaneous Coronary Intervention, 0302 clinical medicine, Retrospective Studie, Femoral access, Internal medicine, medicine, Humans, 030212 general & internal medicine, Retrospective Studies, business.industry, medicine.disease, Radial Artery, Cardiology, Female, coronary angiography, Cardiology and Cardiovascular Medicine, business, Human
Published
2017
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48. Global longitudinal speckle-tracking strain is predictive of left ventricular remodeling after coronary angioplasty in patients with recent non-st elevation myocardial infarction

Author

Biagio Liccardo, Rosangela Cocchia, Sergio Cuomo, Eduardo Bossone, Lucia Riegler, Maurizio Cappelli Bigazzi, Nicolino Esposito, Antonello D'Andrea, Pio Caso, Enrica Golia, Gemma Salerno, Maria Giovanna Russo, Raffaella Scarafile, Raffaele Calabrò, Paolo Calabrò, Giovanni Di Salvo, D'Andrea, A, Cocchia, R, Caso, P, Riegler, L, Scarafile, R, Salerno, G, Golia, E, Di Salvo, G, Calabro, P, Bigazzi, Mc, Liccardo, B, Esposito, N, Cuomo, S, Bossone, E, Russo, Mg, Calabro, R, DI SALVO, Giovanni, Calabro', Paolo, Russo, Maria Giovanna, and Calabro', Raffaele

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Myocardial Infarction, Revascularization, Angina, Reperfusion therapy, Heart Rate, Predictive Value of Tests, Internal medicine, Angioplasty, Humans, Medicine, Myocardial infarction, Angioplasty, Balloon, Coronary, Ventricular remodeling, Aged, Ejection fraction, Ventricular Remodeling, business.industry, Percutaneous coronary intervention, Middle Aged, medicine.disease, Echocardiography, Doppler, Color, Echocardiography, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract

To test whether two-dimensional longitudinal strain (2DSE) performed after revascularization by percutaneous coronary intervention (PCI) could predict left ventricular (LV) remodeling in patients with recent non-ST elevation myocardial infarction (NSTEMI).In 70 patients (62.7 ± 8.7 years) with recent NSTEMI (between 72 hours and 14 days), undergoing coronary angiography for recurrent angina, myocardial deformation parameters were measured by 2DSE before and 24 hours after reperfusion therapy. Strain in all LV segments was averaged to obtain a global value (Global longitudinal Strain--GLS). Infarct size was estimated by clinical parameters and cardiac markers. After 6 months from intervention, LV negative remodeling was defined as lack of improvement of LV function, with increase in LV end-diastolic volume of greater than or equal than 15%.At follow-up, patients were subdivided into remodeled (n=32) and non-remodeled (n = 38) groups. Patients with negative LV remodeling had significantly lower baseline LV ejection fraction (44.8±6.9 vs. 48.7 ± 5.5 %; p0.05), higher peak troponin I (p0.001) and reduced GLS (- 10.6±6.1 vs - 17.6 ± 6.7 % p0.001) than those without LV remodeling. GLS showed a close correlation with peak troponin I after PCI (r = 0.64, P0.0001) and LV WMSI (r = 0.42, p0.01). By multivariable analysis, diabetes mellitus (P0.005), peak of Troponin I after PCI (P0.0005), GLS at baseline (OR: 4.3; p0.0001), and lack of improvement of GLS soon after PCI (OR: 1.45, P0.01) were powerful independent predictors of negative LV remodelling at follow-up. In particular, a GLS ≤ 12 % showed a sensitivity and a specificity respectively of 84.8% and 87.8% to predict negative LV remodelling at follow-up.in patients with recent NSTEMI, longitudinal LV global and regional speckle-tracking strain measurements are powerful independent predictors of LV remodeling after reperfusion therapy.

Published
2011
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49. Use and efficacy of saline hydration and N-acetyl cysteine to prevent contrast-induced nephropathy in low-risk populations undergoing coronary artery angiography

Author

Giuseppe Limongelli, Maurizio Cappelli Bigazzi, Paolo Calabrò, Mario Caprile, Raffaele Calabrò, Mario Crisci, Renatomaria Bianchi, Rosalinda Palmieri, Ilaria Jane Romano, Maria Giovanna Russo, Enrica Golia, Anna De Vita, Calabro', Paolo, Bianchi, R, Crisci, M, Caprile, M, Bigazzi, Mc, Palmieri, R, Golia, E, DE VITA, A, Romano, Ij, Limongelli, Giuseppe, Russo, Maria Giovanna, and Calabro', Raffaele

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Population, Contrast-induced nephropathy, Contrast Media, Sodium Chloride, Coronary Angiography, Gastroenterology, Nephrotoxicity, Nephropathy, chemistry.chemical_compound, Internal medicine, Internal Medicine, medicine, Humans, Risk factor, education, Saline, Retrospective Studies, Creatinine, education.field_of_study, business.industry, Incidence (epidemiology), Free Radical Scavengers, Acute Kidney Injury, Middle Aged, medicine.disease, Acetylcysteine, Surgery, Treatment Outcome, Italy, chemistry, Emergency Medicine, Female, business
Abstract

Contrast-induced nephropathy (CIN) is most commonly defined as acute renal failure occurring within 48-72 h of exposure to an intravascular radiographic contrast medium that is not attributable to other causes. In the international literature, a 25% increase in serum creatinine levels or an increase in absolute values of 0.5 mg/dl from baseline has been suggested to define CIN. The reported incidence of CIN varies widely, ranging from 2 to 50%. This variability results from differences in the presence or absence of risk factors. With a retrospective analysis we evaluated the use of saline hydration plus N-acetyl cysteine (NAC) to prevent CIN in a low-risk population of patients undergoing coronary artery angiography compared with an historic low risk group not treated. From January 2009 to December 2009, 152 consecutive patients who underwent coronary artery angiography with a low osmolarity contrast agent were enrolled in our study, and compared with an historic control group consisting of 172 low-risk patients. Nephrotoxic drugs such as diuretics, ACE-I and ARBs were stopped at least 24 h before the procedure. Inclusion criteria to define low-risk population were the absence of: diabetes, age >65 years, or baseline creatinine >1.4 mg/dl. We have treated group A (152 patients, 47.3%) with a saline hydration (1 ml/kg/h) plus N-acetyl cysteine 600 mg 12 h before and 12 h after the procedure; group B (group control of 170 patients, 52.7%) were not treated. The overall incidence of CIN was 7.1% (23 patients). In particular, the incidence of CIN was 2.6% (4 patients) in the group A and 11.2% (19 patients) in the group B (p = 0.002). In the multivariate analysis, including risk factor such as age, hypertension, hypercholesterolemia, current smoking habit baseline creatinine level, contrast index and hydration, the last variable was the only one inversely correlated independently with the incidence of CIN (p = 0.001). In conclusion, intravenous hydration with saline and NAC is an effective and low cost tool in preventing CIN in patients undergoing coronary artery angiography, and, according to the current guidelines, should be used in all high-risk patients for CIN. Our results show that even in patients at low risk, hydration with saline 0.9% plus NAC is useful and significantly reduces the incidence of CIN.

Published
2011
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50. Left Ventricular Myocardial Velocities and Deformation Indexes in Top-Level Athletes

Author

Eduardo Bossone, Enrica Pezzullo, Giuseppe Pacileo, Sergio Cuomo, Gemma Salerno, Rosangela Cocchia, Pio Caso, Lucia Riegler, Enrica Golia, Rita Gravino, Antonello D'Andrea, Giuseppe Limongelli, Raffaele Calabrò, Rodolfo Citro, Raffaella Scarafile, Maria Giovanna Russo, D'Andrea, A, Cocchia, R, Riegler, L, Scarafile, R, Salerno, G, Gravino, R, Golia, E, Pezzullo, E, Citro, R, Limongelli, Giuseppe, Pacileo, G, Cuomo, S, Caso, P, Russo, Maria Giovanna, Bossone, E, Calabro', Raffaele, Limongelli, G, Russo, Mg, and Calabro, R

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Systole, Population, Diastole, Blood Pressure, Left ventricular hypertrophy, Ventricular Function, Left, Young Adult, Tissue Doppler echocardiography, Heart Rate, Reference Values, Internal medicine, Heart Septum, Image Processing, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Interventricular septum, education, Exercise, Echocardiography, Doppler, Pulsed, education.field_of_study, Ejection fraction, biology, Athletes, business.industry, Resistance Training, Stroke Volume, biology.organism_classification, medicine.disease, Myocardial Contraction, Biomechanical Phenomena, Blood pressure, medicine.anatomical_structure, Echocardiography, Physical Fitness, Multivariate Analysis, Physical Endurance, Cardiology, Hypertrophy, Left Ventricular, Cardiology and Cardiovascular Medicine, business, Software
Abstract

BACKGROUND: The aim of this study was to define the range of left ventricular (LV) velocities and deformation indexes in highly trained athletes, analyzing potential differences induced by different long-term training protocols. METHODS: Standard echocardiography, pulsed-wave tissue Doppler echocardiography, and two-dimensional strain echocardiography of the interventricular septum and lateral wall were performed in 370 endurance athletes and 280 power athletes. Using pulsed-wave tissue Doppler, the following parameters of myocardial function were assessed: systolic peak velocities (S(m)), early (E(m)) and late (A(m)) diastolic velocities, and the E(m)/A(m) ratio. By two-dimensional strain echocardiography, peaks of regional systolic strain and LV global longitudinal strain were calculated. RESULTS: LV mass index and ejection fraction did not significantly differ between the two groups. However, power athletes showed an increased sum of wall thicknesses (P < .01) and relative wall thickness, while LV stroke volume and LV end-diastolic diameter (P < .001) were greater in endurance athletes. By pulsed-wave tissue Doppler analysis, E(m) and E(m)/A(m) at both the septal and lateral wall levels were higher in endurance athletes. By two-dimensional strain echocardiography, myocardial deformation indexes were comparable between the two groups. E(m)/A(m) ratios ≥ 1 were found in the overall population, while 90 % of athletes had an E(m) ≥ 16 cm/sec, S(m) ≥ 10 cm/sec, and global longitudinal strain ≤ -16%. Multivariate analyses evidenced independent positive association between Em peak velocity and LV end-diastolic volume (P < .001) and an independent correlation of global longitudinal strain with the sum of LV wall thicknesses (P < .005). CONCLUSIONS: This study describes the full spectrum of systolic and diastolic myocardial velocities and deformation indexes in a large population of competitive athletes.

Published
2010
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