Search

Your search keyword '"Golfrè Andreasi, Nico"' showing total 23 results
Start Over "Golfrè Andreasi, Nico"
23 results on '"Golfrè Andreasi, Nico"'

2. Bilateral Simultaneous Magnetic Resonance–Guided Focused Ultrasound Pallidotomy for Life‐Threatening Status Dystonicus.

Author

Levi, Vincenzo, Stanziano, Mario, Pinto, Carmela, Zibordi, Federica, Fedeli, Davide, Caldiera, Valentina, Cilia, Roberto, Golfrè Andreasi, Nico, Braccia, Arianna, Carozzi, Carla, Ciceri, Elisa, Grisoli, Marina, Gemma, Marco, Nazzi, Vittoria, DiMeco, Francesco, Eleopra, Roberto, and Zorzi, Giovanna

Abstract

Background: Invasive treatments like radiofrequency stereotactic lesioning or deep brain stimulation of the globus pallidus internus can resolve drug‐resistant status dystonicus (SD). However, these open procedures are not always feasible in patients with SD. Objective: The aim was to report the safety and efficacy of simultaneous asleep bilateral transcranial magnetic resonance–guided focused ultrasound (MRgFUS) pallidotomy for life‐threatening SD. Methods: We performed bilateral simultaneous MRgFUS pallidotomy under general anesthesia in 2 young patients with pantothenate kinase–associated neurodegeneration and GNAO1 encephalopathy. Both patients had medically refractory SD and severe comorbidities contraindicating open surgery. Results: SD resolved at 4 and 12 days after MRgFUS, respectively. Adverse events (intraoperative hypothermia and postoperative facial paralysis) were mild and transient. Conclusion: Bilateral simultaneous MRgFUS pallidotomy under general anesthesia is safe and may be a valid alternative therapeutic option for fragile patients. Further studies are needed to assess long‐term efficacy of the procedure. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Illustration of the Long-Term Efficacy of Pallidal Deep Brain Stimulation in a Patient with PKAN Dystonia

Author

Romito, Luigi M., primary, Colucci, Fabiana, additional, Zorzi, Giovanna, additional, Garavaglia, Barbara, additional, Kaymak, Ahmet, additional, Mazzoni, Alberto, additional, Panteghini, Celeste, additional, Golfrè Andreasi, Nico, additional, Rinaldo, Sara, additional, Levi, Vincenzo, additional, Carecchio, Miryam, additional, and Eleopra, Roberto, additional

Published
2024
Full Text
View/download PDF

4. Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment inGBA-associated Parkinson’s disease: a multicentre, randomised, double-blind, placebo-controlled, phase II trial. The AMBITIOUS study protocol

Author

Colucci, Fabiana, primary, Avenali, Micol, additional, De Micco, Rosita, additional, Fusar Poli, Marco, additional, Cerri, Silvia, additional, Stanziano, Mario, additional, Bacila, Ana, additional, Cuconato, Giada, additional, Franco, Valentina, additional, Franciotta, Diego, additional, Ghezzi, Cristina, additional, Gastaldi, Matteo, additional, Elia, Antonio Emanuele, additional, Romito, Luigi, additional, Devigili, Grazia, additional, Leta, Valentina, additional, Garavaglia, Barbara, additional, Golfrè Andreasi, Nico, additional, Cazzaniga, Federico, additional, Reale, Chiara, additional, Galandra, Caterina, additional, Germani, Giancarlo, additional, Mitrotti, Pierfrancesco, additional, Ongari, Gerardo, additional, Palmieri, Ilaria, additional, Picascia, Marta, additional, Pichiecchio, Anna, additional, Verri, Mattia, additional, Esposito, Fabrizio, additional, Cirillo, Mario, additional, Di Nardo, Federica, additional, Aloisio, Simone, additional, Siciliano, Mattia, additional, Prioni, Sara, additional, Amami, Paolo, additional, Piacentini, Sylvie, additional, Bruzzone, Maria Grazia, additional, Grisoli, Marina, additional, Moda, Fabio, additional, Eleopra, Roberto, additional, Tessitore, Alessandro, additional, Valente, Enza Maria, additional, and Cilia, Roberto, additional

Published
2023
Full Text
View/download PDF

5. Focused ultrasound therapy in movement disorders: management roadmap toward optimal pathway organization.

Author

Rinaldo, Sara, Cilia, Roberto, Leta, Valentina, Gammone, Mariarosaria, Golfrè Andreasi, Nico, Colucci, Fabiana, Braccia, Arianna, Telese, Roberta, Fusar Poli, Marco, Levi, Vincenzo, Antonio Romito, Luigi Michele, Ghilemetti, Francesco, De Martin, Elena, Fumagalli, Maria Luisa, Epifani, Francesca, Prioni, Sara, Amami, Paolo, Piacentini, Sylvie, Elia, Antonio Emanuele, and Devigili, Grazia

Subjects
MOVEMENT disorders, MOVEMENT therapy, PARKINSON'S disease, ESSENTIAL tremor, GLOBUS pallidus
Abstract

MRI-guided focused ultrasound (MRgFUS) lesioning is an innovative, safe and effective treatment which provides an innovative development in the field of minimally invasive stereotactic neurosurgery. Based on the application of focused ultrasound energy under full MR planning and thermal imaging control, unilateral lesioning of the thalamus, subthalamic nucleus, and globus pallidus is indicated for the treatment of movement disorders, including essential tremor, Parkinson's disease, and dystonia. We started to apply this technique in February 2019 for the treatment of patients with movement disorders. The authors developed a diagnostic therapeutic care pathway, which is herewith proposed and applied as an explication of standard clinical practice in use. The project was the result of the application of different methods such as Health Technology Assessment (HTA), Strengths, Weaknesses, Opportunities and Threats analysis (SWOT) and Demin-Plan, Do, Check, Act (PDCA) cycle. The aim of this project was to standardize the MRgFUS diagnostic-therapeutic pathway (DTP), describe its application and the appropriateness of different phases (patient selection, intervention phase and follow-up). Here, we described in detail our experience in the DTP application from 2019 up to now in 610 patients with movement disorders. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. The optimal targeting for focused ultrasound thalamotomy differs between dystonic and essential tremor. A 12‐month prospective pilot study

Author

Golfrè Andreasi, Nico, primary, Braccia, Arianna, additional, Levi, Vincenzo, additional, Rinaldo, Sara, additional, Ghielmetti, Francesco, additional, Cilia, Roberto, additional, Romito, Luigi Michele, additional, Bonvegna, Salvatore, additional, Elia, Antonio Emanuele, additional, Devigili, Grazia, additional, Telese, Roberta, additional, Colucci, Fabiana, additional, Bruzzone, Maria Grazia, additional, Messina, Giuseppe, additional, Corradi, Marta, additional, Stanziano, Mario, additional, Caldiera, Valentina, additional, Prioni, Sara, additional, Amami, Paolo, additional, Fusar Poli, Marco, additional, Piacentini, Sylvie Hélène Marie Jeanne, additional, Grisoli, Marina, additional, Ciceri, Elisa Francesca Maria, additional, DiMeco, Francesco, additional, and Eleopra, Roberto, additional

Published
2023
Full Text
View/download PDF

7. The Optimal Targeting for Focused Ultrasound Thalamotomy Differs between Dystonic and Essential Tremor: A 12‐Month Prospective Pilot Study.

Author

Golfrè Andreasi, Nico, Braccia, Arianna, Levi, Vincenzo, Rinaldo, Sara, Ghielmetti, Francesco, Cilia, Roberto, Romito, Luigi Michele, Bonvegna, Salvatore, Elia, Antonio Emanuele, Devigili, Grazia, Telese, Roberta, Colucci, Fabiana, Bruzzone, Maria Grazia, Messina, Giuseppe, Corradi, Marta, Stanziano, Mario, Caldiera, Valentina, Prioni, Sara, Amami, Paolo, and Fusar Poli, Marco

Subjects
*ESSENTIAL tremor, *LONGITUDINAL method, *PILOT projects, *ODDS ratio, *TREMOR
Abstract

Background: Magnetic resonance‐guided focused ultrasound (MRgFUS) thalamotomy is increasingly used to treat drug‐resistant essential tremor (ET). Data on MRgFUS thalamotomy in dystonic tremor (DT) are anecdotal. Objectives: To investigate efficacy, safety, and differences in target coordinates of MRgFUS thalamotomy in DT versus ET. Methods: Ten patients with DT and 35 with ET who consecutively underwent MRgFUS thalamotomy were followed for 12 months. Although in both groups the initial surgical planning coordinates corresponded to the ventralis intermediate (Vim), the final target could be modified intraoperatively based on clinical response. Results: Tremor significantly improved in both groups. The thalamic lesion was significantly more anterior in DT than ET. Considering both ET and DT groups, the more anterior the lesion, the lower the odds ratio for adverse events. Conclusions: MRgFUS thalamotomy is safe and effective in DT and ET. Compared to classical Vim coordinates used for ET, more anterior targeting should be considered for DT. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Levodopa Equivalent Dose of Safinamide: A Multicenter, Longitudinal, Case–Control Study

Author

Cilia, Roberto, primary, Cereda, Emanuele, additional, Piatti, Marco, additional, Pilotto, Andrea, additional, Magistrelli, Luca, additional, Golfrè Andreasi, Nico, additional, Bonvegna, Salvatore, additional, Contaldi, Elena, additional, Mancini, Francesca, additional, Imbalzano, Gabriele, additional, De Micco, Rosa, additional, Colucci, Fabiana, additional, Braccia, Arianna, additional, Bellini, Gabriele, additional, Brovelli, Francesco, additional, Zangaglia, Roberta, additional, Lazzeri, Giulia, additional, Russillo, Maria Claudia, additional, Olivola, Enrica, additional, Sorbera, Chiara, additional, Cereda, Viviana, additional, Pinto, Patrizia, additional, Sucapane, Patrizia, additional, Gelosa, Giorgio, additional, Meloni, Mario, additional, Pistoia, Francesca, additional, Sessa, Maria, additional, Canesi, Margherita, additional, Modugno, Nicola, additional, Pacchetti, Claudio, additional, Brighina, Laura, additional, Pellecchia, Maria Teresa, additional, Ceravolo, Roberto, additional, Sensi, Mariachiara, additional, Zibetti, Maurizio, additional, Comi, Cristoforo, additional, Padovani, Alessandro, additional, Zecchinelli, Anna L., additional, Di Fonzo, Alessio, additional, Tessitore, Alessandro, additional, Morgante, Francesca, additional, and Eleopra, Roberto, additional

Published
2023
Full Text
View/download PDF

9. Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study

Author

Golfrè Andreasi, Nico, primary, Cilia, Roberto, additional, Romito, Luigi Michele, additional, Bonvegna, Salvatore, additional, Straccia, Giulia, additional, Elia, Antonio Emanuele, additional, Novelli, Alessio, additional, Messina, Giuseppe, additional, Tringali, Giovanni, additional, Levi, Vincenzo, additional, Devigili, Grazia, additional, Rinaldo, Sara, additional, Gasparini, Valentina, additional, Grisoli, Marina, additional, Stanziano, Mario, additional, Ghielmetti, Francesco, additional, Prioni, Sara, additional, Bocchi, Elisa, additional, Amami, Paolo, additional, Piacentini, Sylvie Hélène Marie Jeanne, additional, Ciceri, Elisa Francesca Maria, additional, Bruzzone, Maria Grazia, additional, and Eleopra, Roberto, additional

Published
2022
Full Text
View/download PDF

12. Cerebrospinal fluid neuropathological biomarkers in beta-propeller protein-associated neurodegeneration, with complicated parkinsonian phenotype

Author

Bonomo, R, Elia, A, Cilia, R, Romito, L, Golfrè Andreasi, N, Devigili, G, Bonvegna, S, Straccia, G, Garavaglia, B, Panteghini, C, Eleopra, R, Bonomo, Roberta, Elia, Antonio E, Cilia, Roberto, Romito, Luigi M, Golfrè Andreasi, Nico, Devigili, Grazia, Bonvegna, Salvatore, Straccia, Giulia, Garavaglia, Barbara, Panteghini, Celeste, Eleopra, Roberto, Bonomo, R, Elia, A, Cilia, R, Romito, L, Golfrè Andreasi, N, Devigili, G, Bonvegna, S, Straccia, G, Garavaglia, B, Panteghini, C, Eleopra, R, Bonomo, Roberta, Elia, Antonio E, Cilia, Roberto, Romito, Luigi M, Golfrè Andreasi, Nico, Devigili, Grazia, Bonvegna, Salvatore, Straccia, Giulia, Garavaglia, Barbara, Panteghini, Celeste, and Eleopra, Roberto

Published
2022

13. Pain related to MRgFUS: a merely minor transient adverse event?

Author

Amami, Paolo, Prioni, Sara, Fusar Poli, Marco, Pascuzzo, Riccardo, Bocchi, Elisa, Golfrè Andreasi, Nico, Devigili, Grazia, Cilia, Roberto, Rinaldo, Sara, Levi, Vincenzo, Ghielmetti, Francesco, Grisoli, Marina, Gemma, Marco, DiMeco, Francesco, Eleopra, Roberto, and Piacentini, Sylvie

Published
2024
Full Text
View/download PDF

15. Resting State Functional Connectivity Signatures of MRgFUS Vim Thalamotomy in Parkinson's Disease: A Preliminary Study

Author

Stanziano, Mario, primary, Golfrè Andreasi, Nico, additional, Messina, Giuseppe, additional, Rinaldo, Sara, additional, Palermo, Sara, additional, Verri, Mattia, additional, Demichelis, Greta, additional, Medina, Jean Paul, additional, Ghielmetti, Francesco, additional, Bonvegna, Salvatore, additional, Nigri, Anna, additional, Frazzetta, Giulia, additional, D'Incerti, Ludovico, additional, Tringali, Giovanni, additional, DiMeco, Francesco, additional, Eleopra, Roberto, additional, and Bruzzone, Maria Grazia, additional

Published
2022
Full Text
View/download PDF

16. Short- and long-term motor outcome of STN-DBS in Parkinson’s Disease: focus on sex differences

Author

Golfrè Andreasi, Nico, primary, Romito, Luigi Michele, additional, Telese, Roberta, additional, Cilia, Roberto, additional, Elia, Antonio Emanuele, additional, Novelli, Alessio, additional, Tringali, Giovanni, additional, Messina, Giuseppe, additional, Levi, Vincenzo, additional, Devigili, Grazia, additional, Rinaldo, Sara, additional, Franzini, Angelo Amato, additional, and Eleopra, Roberto, additional

Published
2021
Full Text
View/download PDF

20. Quantitative Tractography‐Based Evaluations in Essential Tremor Patients after MRgFUS Thalamotomy.

Author

Ghielmetti, Francesco, Aquino, Domenico, Golfrè Andreasi, Nico, Mazzi, Federica, Greco, Elena, Cilia, Roberto, De Martin, Elena, Rinaldo, Sara, Stanziano, Mario, Levi, Vincenzo, Braccia, Arianna, Marchetti, Marcello, Fumagalli, Maria L., Demichelis, Greta, Colucci, Fabiana, Romito, Luigi Michele, Devigili, Grazia, Elia, Antonio E., Caldiera, Valentina, and Verri, Mattia

Subjects
*ESSENTIAL tremor, *TREATMENT effectiveness, *CENTER of mass, *MAGNETIC resonance imaging, *TREMOR
Abstract

Background Objectives Methods Results Conclusion Magnetic resonance‐guided focused ultrasound (MRgFUS) targeting the thalamic ventral intermediate nucleus (VIM) is an innovative treatment for drug‐refractory essential tremor (ET). The relationship between lesion characteristics, dentate‐rubro‐thalamic‐tract (DRTT) involvement and clinical benefit remains unclear.To investigate whether clinical outcome is related to lesion volume and/or its overlap with the DRTT. To compare the reliability of probabilistic versus deterministic tractography in reconstructing the DRTT and improving VIM targeting.Forty ET patients who underwent MRgFUS thalamotomy between 2019 and 2022 were retrospectively analyzed. Clinical outcomes and adverse effects were recorded at 1/6/12 months after the procedure. The DRTT was generated using deterministic and probabilistic tractography on preoperative diffusion‐tensor 3 T‐images and location and volume of the lesion were calculated.Probabilistic tractography identified both decussating (d‐DRTT) and non‐decussating (nd‐DRTT) components of the DRTT, whereas the deterministic approach only identified one component overlapping with the nd‐DRTT. Despite the lesions predominantly intersecting the medial portion of the d‐DRTT, with a significantly greater overlap in responder patients, we observed only a non‐significant correlation between tremor improvement and increased d‐DRTT‐lesion overlap (r = 0.22, P = 0.20). The lesion volume demonstrated a significant positive correlation with clinical improvement at 1‐day MRI (r = 0.42, P < 0.01).Variability in the reconstructed DRTT position relative to the lesion center of mass, even among good responders, suggests that this fiber bundle is unlikely to be considered the sole target for a successful MRgFUS thalamotomy in ET. Indirect individualized targeting allows for more precise and reproducible identification of actual treatment coordinates than the direct method. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

21. Levodopa/Carbidopa Intestinal Gel Infusion Therapy: Focus on Gait and Balance

Author

Rispoli, Vittorio, Golfrè Andreasi, Nico, Penna, Giovanna, Preda, Francesca, Contini, Eleonora, and Sensi, Mariachiara

Subjects
genetic structures, Case Series
Abstract

BACKGROUND: Gait and balance disorders in advanced Parkinson's disease (aPD) heavily impact the disease burden. In this prospective observational open‐label study, our aim was to evaluate the effectiveness of levodopa/carbidopa intestinal gel (LCIG) infusion on balance and gait over a long‐term follow‐up. METHODS: The motor status of 15 aPD patients with balance and gait symptoms was assessed with UPDRS (I–IV) and H&Y at baseline in OFF and ON conditions, and after 52 weeks of LCIG infusion. Berg Balance Scale (BBS), Tinetti Gait & Balance Score (TS), Gait and Falls Questionnaire (G&F‐Q), FOG Questionnaire (FOG‐Q), and New FOG Questionnaire (NFOG‐Q) were used to specifically test balance and gait. RESULTS: UPDRS, H&Y, BBS, TS, G&F‐Q, FOG‐Q, NFOG‐Q improved significantly. All FOG types benefited from LCIG. CONCLUSIONS: Our preliminary data show the beneficial effect of LCIG therapy not only on FOG, but also on gait and balance. Results need to be confirmed in larger cohort studies.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results