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2. An epigenetic barrier sets the timing of human neuronal maturation

Author

Ciceri, Gabriele, Baggiolini, Arianna, Cho, Hyein S., Kshirsagar, Meghana, Benito-Kwiecinski, Silvia, Walsh, Ryan M., Aromolaran, Kelly A., Gonzalez-Hernandez, Alberto J., Munguba, Hermany, Koo, So Yeon, Xu, Nan, Sevilla, Kaylin J., Goldstein, Peter A., Levitz, Joshua, Leslie, Christina S., Koche, Richard P., and Studer, Lorenz

Published
2024
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4. An anchor-tether ‘hindered’ HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model

Author

Tibbs, Gareth R., Uprety, Rajendra, Warren, J. David, Beyer, Nicole P., Joyce, Rebecca L., Ferrer, Matthew A., Mellado, Wilfredo, Wong, Victor S.C., Goldberg, David C., Cohen, Melanie W., Costa, Christopher J., Li, Zhucui, Zhang, Guoan, Dephoure, Noah E., Barman, Dipti N., Sun, Delin, Ingólfsson, Helgi I., Sauve, Anthony A., Willis, Dianna E., and Goldstein, Peter A.

Published
2023
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5. Immunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus–diphtheria–acellular pertussis vaccine: a randomised, double-blind, phase 2b trial

Author

Keech, Cheryl, Miller, Vicki E, Rizzardi, Barbara, Hoyle, Christopher, Pryor, Melinda J, Ferrand, Jonathan, Solovay, Ken, Thalen, Marcel, Noviello, Stephanie, Goldstein, Peter, Gorringe, Andrew, Cavell, Breeze, He, Qiushui, Barkoff, Alex-Mikael, Rubin, Keith, and Locht, Camille

Published
2023
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6. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Hemmes, Sabrine NT., Gama de Abreu, Marcelo, Severgnini, Paolo, Hollmann, Markus W., Binnekade, Jan M., Wrigge, Hermann, Canet, Jaume, Hiesmayr, Michael, Schmid, Werner, Tschernko, Edda, Jaber, Samir, Hedenstierna, Göran, Putensen, Christian, Pelosi, Paolo, Schultz, Marcus J., Marti, Agnes, Bacuzzi, Alessandro, Brodhun, Alexander, Molin, Alexandre, Merten, Alfred, Parera, Ana, Brunelli, Andrea, Cortegiani, Andrea, Güldner, Andreas, Reske, Andreas W., Gratarola, Angelo, Giarratano, Antonino, Bastin, Bea, Heyse, Bjorn, Mazul-Sunko, Branka, Amantea, Bruno, Barberis, Bruno, Uhlig, Christopher, Marín, Conrado Minguez, Celentano, Cristian, La Bella, Daniela, D’Antini, David, Velghe, David, Sulemanji, Demet, De Robertis, Edoardo, Hartmann, Eric, Montalto, Francesca, Tropea, Francesco, Mills, Gary H., Cinnella, Gilda, Della Rocca, Giorgio, Caggianelli, Girolamo, Pellerano, Giulia, Mollica, Giuseppina, Bugedo, Guillermo, Mulier, Jan-Paul, Vandenbrande, Jeroen, Geib, Johann, Yaqub, Jonathan, Florez, Jorge, Mayoral, Juan F., Sprung, Juraj, Van Limmen, Jurgen, Bos, Lieuwe DJ., de Baerdemaeker, Luc, Jamaer, Luc, Spagnolo, Luigi, Strys, Lydia, Gil, Manuel Granell, Vidal Melo, Marcos F., Unzueta, Maria Carmen, Moral, Maria Victoria, Ferner, Marion, Weiss, Martin, Vanoni, Massimo, Schaefer, Maximilian S., Prieto, Mercè, Grio, Michele, Spieth, Peter Markus, Simon, Philipp, Bodger, Phoebe, Sierra, Pilar, Laufenberg-Feldmann, Rita, Rusca, Roberta, Proietti, Rodolfo, Raineri, Santi Maurizio, Caroleo, Santo, Sabaté, Sergi, De Hert, Stefan, Pezzato, Stefano, Treschan, Tanja A., Goranovic, Tatjana, Koch, Thea, Bluth, Thomas, Kiss, Thomas, Perilli, Valter, Cegarra, Virginia, Ferrando, Carlos, Belda, Javier, Soro, Marina, Unzueta, Carmen, Suarez-Sipmann, Fernando, Librero, Julián, Llombart, Alicia, Rovira, Lucas, Granell, Manuel, Aldecoa, César, Diaz-Cambronero, Oscar, Balust, Jaume, Garutti, Ignacio, Gonzalez, Rafael, Gallego, Lucia, Garcia del Valle, Santiago, Redondo, Javier, Pestaña, David, Rodríguez, Aurelio, García, Javier, Matta, Manuel de la, Ibáñez, Maite, Barrios, Francisco, Hernández, Samuel, Torres, Vicente, Peiró, Salvador, Pozo, Natividad, Villena, Abigail, Carramiñana, Albert, Gallego-Casilda, Alberto, Duca, Alejandro, Alcón, Amalia, Miñana, Amanda, Asensio, Ana, Colás, Ana, Galve, Ana Isabel, Izquierdo, Ana, Jurado, Ana, Pérez, Ana María, Mugarra, Ana, Gutierrez, Andrea, De Miguel, Ángeles, Lozano, Angels, Katime, Antonio, Romero, Antonio, Garrigues, Beatriz, Ayas, Begoña, Arocas, Blanca, Delgado, Carlos, Fernández, Carmen, Romero, Carolina, Gallego, Clara, Garcés, Cristina, Lisbona, Cristina, Parrilla, Cristina, López-Herrera, Daniel, González, Domingo, Llamazares, Eduardo, Del Rio, Elena, Lozano, Elena, Pastor, Ernesto, Chamorro, Estefanía, Gracia, Estefanía, Sánchez, Ester, Romero, Esther, Díez, Fernando, Serralta, Ferran, Daviu, Francisco, Sandín, Francisco, Aguilar, Gerardo, Tusman, Gerardo, Azparren, Gonzalo, Martínez-Pallí, Graciela, Mazzinari, Guido, Benítez, Inmaculada, Hernandéz, Inmaculada, India, Inmaculada, León, Irene, Fuentes, Isabel, Ruiz, Isabel, Puig, Jaume, Román, Javie Ignacio, Acosta, Jesús, Rico-Feijoo, Jesús, Olmedo, Jonathan, Carbonell, Jose A., Alonso, Jose M., Pérez, Jose María, Marcos, Jose Miguel, Navarro, Jose, Valdivia, Jose, Carrizo, Juan, Piqueras, Laura, Soriano, Laura, Vaquero, Laura, Miguel, Lisset, Muñoz, Lorena, Valencia, Lucia, Olmedilla, Luis, Etulain, Mᵃ Justina, Tisner, Manuel, Barrio, María, Alonso, María Dolores, García, María, Hernández, María J., Alberola, María José, Parra, María, Argente, María Pilar, Vila, María, De Fez, Mario, Agilaga, Marta, Gine, Marta, Ayuso, Mercedes, García, Mercedes, Bejarano, Natalia, Peña, Natalia, Ojeda, Nazario, Martínez, Nilda, García, Nuria, Padrón, Oto, García, Pablo, Valls, Paola, Cruz, Patricia, Piñeiro, Patricia, Charco, Pedro, Anaya, Rafael, López, Ramiro, Rodríguez, Rayco, Martínez, Rocío, Pujol, Roger, Dosdá, Rosa, Lardies, Rosa, Díaz, Ruben, Villazala, Rubén, Zapatero, Sara, Cabrera, Sergio, Sánchez, Sergio, Martin, Silvia, Diaz, Suzana, Franco, Tania, Moreno, Tania, Socorro, Tania, Gilabert, Vicente, Balandrón, Victor, Moral, Victoria, Cegarra, Virgina, Varón, Viviana, Abelha, Fernando, Abitağaoğlu, Sühayla, Achilles, Marc, Adebesin, Afeez, Adriaensens, Ine, Ahene, Charles, Akbar, Fatima, Al Harbi, Mohammed, Al Khoury al Kallab, Rita, Albanel, Xavier, Aldenkortt, Florence, Saleh Alfouzan, Rawan Abdullah, Alruqaie, Reef, Altermatt, Fernando, Luís de Castro Araujo, Bruno, Arbesú, Genaro, Artsi, Hanna, Aurilio, Caterina, Ayanoglu, Omer Hilmi, Baig, Harris, Baird, Yolanda, Balonov, Konstantin, Banks, Samantha, Bao, Xiaodong, Baumgartner, Mélanie, Tortosa, Isabel Belda, Bergamaschi, Alice, Bergmann, Lars, Bigatello, Luca, Pérez, Elena Biosca, Birr, Katja, Bojaxhi, Elird, Bonenti, Chiara, Bonney, Iwona, Bos, Elke M.E., Bowman, Sara, Braz, Leandro Gobbo, Brugnoni, Elisa, Brull, Sorin J., Brunetti, Iole, Bruni, Andrea, Buenvenida, Shonie L., Busch, Cornelius Johannes, Camerini, Giovanni, Capatti, Beatrice, Carmona, Javiera, Carungcong, Jaime, Carvalho, Marta, Cattan, Anat, Cavaleiro, Carla, Chiumello, Davide, Ciardo, Stefano, Coburn, Mark, Colella, Umberto, Contreras, Victor, Dincer, Pelin Corman, Cotter, Elizabeth, Crovetto, Marcia, Darrah, William, Davies, Simon, Del Cojo Peces, Enrique, Delphin, Ellise, Diaper, John, Junior, Paulo do Nascimento, Donatiello, Valerio, Dong, Jing, Dourado, Maria do Socorro, Dullenkopf, Alexander, Ebner, Felix, Elgendy, Hamed, Ellenberger, Christoph, Arı, Dilek Erdoğan, Ermert, Thomas, Farah, Fadi, Fernandez-Bustamante, Ana, Ferreira, Cristina, Fiore, Marco, Fonte, Ana, Palahí, Christina Fortià, Galimberti, Andrea, Garofano, Najia, Giaccari, Luca Gregorio, Gilsanz, Fernando, Girrbach, Felix, Gobbi, Luca, Godfried, Marc Bernard, Goettel, Nicolai, Goldstein, Peter A., Goren, Or, Gorlin, Andrew, Graterol, Juan, Guyon, Pierre, Haire, Kevin, Harou, Philippe, Helf, Antonia, Hemmes, Sabrine N.T., Hempel, Gunther, Hernández Cádiz, María José, Heyse, Björn, Huercio, Ivan, Ilievska, Jasmina, Jakus, Lien, Jeganath, Vijay, Jelting, Yvonne, Jung, Minoa, Kabon, Barbara, Kacha, Aalok, Ilić, Maja Karaman, Karuppiah, Arunthevaraja, Kavas, Ayse Duygu, Barcelos, Gleicy Keli, Kellogg, Todd A., Kemper, Johann, Kerbrat, Romain, Khodr, Suraya, Kienbaum, Peter, Kir, Bunyamin, Kivrak, Selin, Klarić, Vlasta, Köksal, Ceren, Kowark, Ana, Kranke, Peter, Kuvaki, Bahar, Kuzmanovska, Biljana, Laffey, John, Lange, Mirko, Freitas de Lemos, Marília, Licker, Marc-Joseph, López-Baamonde, Manuel, López-Hernández, Antonio, Lopez-Martinez, Mercedes, Luise, Stéphane, MacGregor, Mark, Magalhães, Danielle, Maillard, Julien, Malerbi, Patrizia, Manimekalai, Natesan, Margarson, Michael, Markstaller, Klaus, Martin, Archer K., Martin, David P., Martin, Yvette N., Martínez-Ocon, Julia, Martin-Loeches, Ignacio, Maseda, Emilio, Matot, Idit, McAuliffe, Niamh, McKenzie, Travis J., Medina, Paulina, Meersch, Melanie, Menzen, Angelika, Mertens, Els, Meurer, Bernd, Meyer-Treschan, Tanja, Miao, Changhong, Micalizzi, Camilla, Milić, Morena, Pinheiro Módolo, Norma Sueli, Moine, Pierre, Mölders, Patrick, Montero-Feijoo, Ana, Moret, Enrique, Muller, Markus K., Murphy, Zoe, Nalwaya, Pramod, Naumovski, Filip, Navalesi, Paolo, Navarro e Lima, Lais Helena, Adam, Višnja Nesek, Neumann, Claudia, Newell, Christopher, Nisnevitch, Zoulfira, Nizamuddin, Junaid, Novazzi, Cecilia, O'Connor, Michael, Oprea, Günther, Sungur, Mukadder Orhan, Özbilgin, Şule, Pace, Maria Caterina, Pacheco, Marcos, Packianathaswamy, Balaji, Gonzalez, Estefania Palma, Papaspyros, Fotios, Paredes, Sebastián, Passavanti, Maria Beatrice, Pedemonte, Juan Cristobal, Peremin, Sanja, Philipsenburg, Christoph, Pinho, Daniela, Pinho, Silvia, Posthuma, Linda M., Pota, Vincenzo, Preckel, Benedikt, Priani, Paolo, Rached, Mohamed Aymen, Radoeshki, Aleksandar, Ragazzi, Riccardo, Rajamanickam, Tamilselvan, Rajamohan, Arthi, Ramakrishna, Harish, Rangarajan, Desikan, Reiterer, Christian, Renew, J. Ross, Reynaud, Thomas, Rhys, Rhidian, Rivas, Eva, Robitzky, Luisa, Rossaint, Rolf, Rubulotta, Francesca, Machado, Humberto S., Nunes, Catarina S., Sabbatini, Giovanni, Samuels, Jon D., Sanahuja, Josep Martí, Sansone, Pasquale, Santos, Alice, Sayedalahl, Mohamed, Scharffenberg, Martin, Schiffer, Eduardo, Schliewe, Nadja, Schorer, Raoul, Schumann, Roman, Selmo, Gabriele, Sendra, Mar, Senturk, Mert, Shaw, Kate, Shosholcheva, Mirjana, Sibai, Abdulrazak, Simonassi, Francesca, Sinno, Claudia, Sivrikoz, Nukhet, Skandalou, Vasiliki, Smith, Neil, Soares, Maria, Artiles, Tania Socorro, Castro, Diogo Sousa, Sousa, Miguel, Spadaro, Savino, Stamatakis, Emmanouil, Steiner, Luzius A., Stevenazzi, Andrea, Suarez-de-la-Rica, Alejandro, Suppan, Mélanie, Teichmann, Robert, Tena Guerrero, José Maria, Thiel, Bram, Tolós, Raquel, Altun, Gulbin Tore, Tucci, Michelle, Turnbull, Zachary A., Turudić, Žana, Unterberg, Matthias, Van Nieuwenhove, Yves, Van Waesberghe, Julia, Vidal Melo, Marcos Francisco, Vitković, Bibiana, Vivona, Luigi, Vizcaychipi, Marcela, Volta, Carlo Alberto, Weber, Anne, Weingarten, Toby N., Wittenstein, Jakob, Wyffels, Piet, Yagüe, Julio, Yates, David, Yavru, Ayşen, Zac, Lilach, Zhong, Jing, Campos, Niklas S., Librero, Julian, Ball, Lorenzo, and Serpa Neto, A.

Published
2022
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8. BILLIONS OF DOLLARS ARE BEING INVESTED IN NORTH CAROLINA FOR THE DEVELOPMENT OF THE NEWEST TOOL FOR BUSINESS: ARTIFICIAL INTELLIGENCE.

Author

Boyd, Richard, Cukic, Bojan, Fruth, Darrell, Goldstein, Peter, McClure, Alice, and Olson, Todd

Subjects
ARTIFICIAL intelligence, GENERATIVE artificial intelligence, LANGUAGE models
Abstract

Billions of dollars are being invested in North Carolina to develop artificial intelligence (AI) tools for businesses. Companies like Lenovo, N.C. State, and Cerebras Systems are partnering to create AI applications in agriculture, education, healthcare, and finance. However, there are challenges surrounding AI, such as the mismatch between expectations and reality, the responsibility when things go wrong, and the fear of job displacement. It is important for individuals to become AI literate, and for companies to focus on growth and create new service-oriented jobs. Education should also incorporate AI concepts to prepare students for the workforce. Law firms are exploring the use of AI for tasks like drafting briefs and negotiating contracts. The article discusses the potential impact of AI in various industries, including healthcare, construction, and transportation. Participants in the discussion express different perspectives on the benefits and challenges of AI. They emphasize the need for data-driven decision-making, transparency, and regulation, and the potential for AI to improve safety and efficiency. Overall, they are cautiously optimistic about the future of AI and its potential to drive economic growth and equalize opportunities. [Extracted from the article]

Published
2024

13. Targeted Deletion of Kcne2 Impairs HCN Channel Function in Mouse Thalamocortical Circuits

Author

Ying, Shui-Wang, Kanda, Vikram A., Hu, Zhaoyang, Purtell, Kerry, King, Elizabeth C., Abbott, Geoffrey W., and Goldstein, Peter A.

Subjects
activated cation channels, reticular thalamic neurons, mink-related peptide-1, potassium channels, i-h, pacemaker channels, relay neurons, absence epilepsy, physiological-function, propofol-block
Abstract

BackgroundHyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the pacemaking current, Ih, which regulates neuronal excitability, burst firing activity, rhythmogenesis, and synaptic integration. The physiological consequence of HCN activation depends on regulation of channel gating by endogenous modulators and stabilization of the channel complex formed by principal and ancillary subunits. KCNE2 is a voltage-gated potassium channel ancillary subunit that also regulates heterologously expressed HCN channels; whether KCNE2 regulates neuronal HCN channel function is unknown.Methodology/Principal FindingsWe investigated the effects of Kcne2 gene deletion on Ih properties and excitability in ventrobasal (VB) and cortical layer 6 pyramidal neurons using brain slices prepared from Kcne2+/+ and Kcne2−/− mice. Kcne2 deletion shifted the voltage-dependence of Ih activation to more hyperpolarized potentials, slowed gating kinetics, and decreased Ih density. Kcne2 deletion was associated with a reduction in whole-brain expression of both HCN1 and HCN2 (but not HCN4), although co-immunoprecipitation from whole-brain lysates failed to detect interaction of KCNE2 with HCN1 or 2. Kcne2 deletion also increased input resistance and temporal summation of subthreshold voltage responses; this increased intrinsic excitability enhanced burst firing in response to 4-aminopyridine. Burst duration increased in corticothalamic, but not thalamocortical, neurons, suggesting enhanced cortical excitatory input to the thalamus; such augmented excitability did not result from changes in glutamate release machinery since miniature EPSC frequency was unaltered in Kcne2−/− neurons.Conclusions/SignificanceLoss of KCNE2 leads to downregulation of HCN channel function associated with increased excitability in neurons in the cortico-thalamo-cortical loop. Such findings further our understanding of the normal physiology of brain circuitry critically involved in cognition and have implications for our understanding of various disorders of consciousness.

Published
2012

16. Examining the Effects of Soil Entrainment During Nuclear Cloud Rise on Fallout Predictions Using a Multiscale Atmospheric Modeling Framework

Author

Lundquist, Katherine, primary, Arthur, Robert, additional, Neuscamman, Stephanie, additional, Morris, Joseph, additional, Scullard, Christian, additional, Cook, Andrew, additional, Wimer, Nathan, additional, Goldstein, Peter, additional, Spriggs, Gregory, additional, Glascoe, Lee, additional, and Nasstrom, John, additional

Published
2023
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28. An epigenetic barrier sets the timing of human neuronal maturation

Author

Ciceri, Gabriele, primary, Cho, Hyunwoo, additional, Kshirsagar, Meghana, additional, Baggiolini, Arianna, additional, Aromolaran, Kelly A, additional, Walsh, Ryan M, additional, Goldstein, Peter A, additional, Koche, Richard P., additional, Leslie, Christina S, additional, and Studer, Lorenz, additional

Published
2022
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29. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Campos, Niklas S., primary, Bluth, Thomas, additional, Hemmes, Sabrine N.T., additional, Librero, Julian, additional, Pozo, Natividad, additional, Ferrando, Carlos, additional, Ball, Lorenzo, additional, Mazzinari, Guido, additional, Pelosi, Paolo, additional, Gama de Abreu, Marcelo, additional, Schultz, Marcus J., additional, Serpa Neto, A., additional, Hemmes, Sabrine NT., additional, Severgnini, Paolo, additional, Hollmann, Markus W., additional, Binnekade, Jan M., additional, Wrigge, Hermann, additional, Canet, Jaume, additional, Hiesmayr, Michael, additional, Schmid, Werner, additional, Tschernko, Edda, additional, Jaber, Samir, additional, Hedenstierna, Göran, additional, Putensen, Christian, additional, Marti, Agnes, additional, Bacuzzi, Alessandro, additional, Brodhun, Alexander, additional, Molin, Alexandre, additional, Merten, Alfred, additional, Parera, Ana, additional, Brunelli, Andrea, additional, Cortegiani, Andrea, additional, Güldner, Andreas, additional, Reske, Andreas W., additional, Gratarola, Angelo, additional, Giarratano, Antonino, additional, Bastin, Bea, additional, Heyse, Bjorn, additional, Mazul-Sunko, Branka, additional, Amantea, Bruno, additional, Barberis, Bruno, additional, Uhlig, Christopher, additional, Marín, Conrado Minguez, additional, Celentano, Cristian, additional, La Bella, Daniela, additional, D’Antini, David, additional, Velghe, David, additional, Sulemanji, Demet, additional, De Robertis, Edoardo, additional, Hartmann, Eric, additional, Montalto, Francesca, additional, Tropea, Francesco, additional, Mills, Gary H., additional, Cinnella, Gilda, additional, Della Rocca, Giorgio, additional, Caggianelli, Girolamo, additional, Pellerano, Giulia, additional, Mollica, Giuseppina, additional, Bugedo, Guillermo, additional, Mulier, Jan-Paul, additional, Vandenbrande, Jeroen, additional, Geib, Johann, additional, Yaqub, Jonathan, additional, Florez, Jorge, additional, Mayoral, Juan F., additional, Sprung, Juraj, additional, Van Limmen, Jurgen, additional, Bos, Lieuwe DJ., additional, de Baerdemaeker, Luc, additional, Jamaer, Luc, additional, Spagnolo, Luigi, additional, Strys, Lydia, additional, Gil, Manuel Granell, additional, Vidal Melo, Marcos F., additional, Unzueta, Maria Carmen, additional, Moral, Maria Victoria, additional, Ferner, Marion, additional, Weiss, Martin, additional, Vanoni, Massimo, additional, Schaefer, Maximilian S., additional, Prieto, Mercè, additional, Grio, Michele, additional, Spieth, Peter Markus, additional, Simon, Philipp, additional, Bodger, Phoebe, additional, Sierra, Pilar, additional, Laufenberg-Feldmann, Rita, additional, Rusca, Roberta, additional, Proietti, Rodolfo, additional, Raineri, Santi Maurizio, additional, Caroleo, Santo, additional, Sabaté, Sergi, additional, De Hert, Stefan, additional, Pezzato, Stefano, additional, Treschan, Tanja A., additional, Goranovic, Tatjana, additional, Koch, Thea, additional, Kiss, Thomas, additional, Perilli, Valter, additional, Cegarra, Virginia, additional, Belda, Javier, additional, Soro, Marina, additional, Unzueta, Carmen, additional, Suarez-Sipmann, Fernando, additional, Librero, Julián, additional, Llombart, Alicia, additional, Rovira, Lucas, additional, Granell, Manuel, additional, Aldecoa, César, additional, Diaz-Cambronero, Oscar, additional, Balust, Jaume, additional, Garutti, Ignacio, additional, Gonzalez, Rafael, additional, Gallego, Lucia, additional, Garcia del Valle, Santiago, additional, Redondo, Javier, additional, Pestaña, David, additional, Rodríguez, Aurelio, additional, García, Javier, additional, Matta, Manuel de la, additional, Ibáñez, Maite, additional, Barrios, Francisco, additional, Hernández, Samuel, additional, Torres, Vicente, additional, Peiró, Salvador, additional, Villena, Abigail, additional, Carramiñana, Albert, additional, Gallego-Casilda, Alberto, additional, Duca, Alejandro, additional, Alcón, Amalia, additional, Miñana, Amanda, additional, Asensio, Ana, additional, Colás, Ana, additional, Galve, Ana Isabel, additional, Izquierdo, Ana, additional, Jurado, Ana, additional, Pérez, Ana María, additional, Mugarra, Ana, additional, Gutierrez, Andrea, additional, De Miguel, Ángeles, additional, Lozano, Angels, additional, Katime, Antonio, additional, Romero, Antonio, additional, Garrigues, Beatriz, additional, Ayas, Begoña, additional, Arocas, Blanca, additional, Delgado, Carlos, additional, Fernández, Carmen, additional, Romero, Carolina, additional, Gallego, Clara, additional, Garcés, Cristina, additional, Lisbona, Cristina, additional, Parrilla, Cristina, additional, López-Herrera, Daniel, additional, González, Domingo, additional, Llamazares, Eduardo, additional, Del Rio, Elena, additional, Lozano, Elena, additional, Pastor, Ernesto, additional, Chamorro, Estefanía, additional, Gracia, Estefanía, additional, Sánchez, Ester, additional, Romero, Esther, additional, Díez, Fernando, additional, Serralta, Ferran, additional, Daviu, Francisco, additional, Sandín, Francisco, additional, Aguilar, Gerardo, additional, Tusman, Gerardo, additional, Azparren, Gonzalo, additional, Martínez-Pallí, Graciela, additional, Benítez, Inmaculada, additional, Hernandéz, Inmaculada, additional, India, Inmaculada, additional, León, Irene, additional, Fuentes, Isabel, additional, Ruiz, Isabel, additional, Puig, Jaume, additional, Román, Javie Ignacio, additional, Acosta, Jesús, additional, Rico-Feijoo, Jesús, additional, Olmedo, Jonathan, additional, Carbonell, Jose A., additional, Alonso, Jose M., additional, Pérez, Jose María, additional, Marcos, Jose Miguel, additional, Navarro, Jose, additional, Valdivia, Jose, additional, Carrizo, Juan, additional, Piqueras, Laura, additional, Soriano, Laura, additional, Vaquero, Laura, additional, Miguel, Lisset, additional, Muñoz, Lorena, additional, Valencia, Lucia, additional, Olmedilla, Luis, additional, Etulain, Mᵃ Justina, additional, Tisner, Manuel, additional, Barrio, María, additional, Alonso, María Dolores, additional, García, María, additional, Hernández, María J., additional, Alberola, María José, additional, Parra, María, additional, Argente, María Pilar, additional, Vila, María, additional, De Fez, Mario, additional, Agilaga, Marta, additional, Gine, Marta, additional, Ayuso, Mercedes, additional, García, Mercedes, additional, Bejarano, Natalia, additional, Peña, Natalia, additional, Ojeda, Nazario, additional, Martínez, Nilda, additional, García, Nuria, additional, Padrón, Oto, additional, García, Pablo, additional, Valls, Paola, additional, Cruz, Patricia, additional, Piñeiro, Patricia, additional, Charco, Pedro, additional, Anaya, Rafael, additional, López, Ramiro, additional, Rodríguez, Rayco, additional, Martínez, Rocío, additional, Pujol, Roger, additional, Dosdá, Rosa, additional, Lardies, Rosa, additional, Díaz, Ruben, additional, Villazala, Rubén, additional, Zapatero, Sara, additional, Cabrera, Sergio, additional, Sánchez, Sergio, additional, Martin, Silvia, additional, Diaz, Suzana, additional, Franco, Tania, additional, Moreno, Tania, additional, Socorro, Tania, additional, Gilabert, Vicente, additional, Balandrón, Victor, additional, Moral, Victoria, additional, Cegarra, Virgina, additional, Varón, Viviana, additional, Abelha, Fernando, additional, Abitağaoğlu, Sühayla, additional, Achilles, Marc, additional, Adebesin, Afeez, additional, Adriaensens, Ine, additional, Ahene, Charles, additional, Akbar, Fatima, additional, Al Harbi, Mohammed, additional, Al Khoury al Kallab, Rita, additional, Albanel, Xavier, additional, Aldenkortt, Florence, additional, Saleh Alfouzan, Rawan Abdullah, additional, Alruqaie, Reef, additional, Altermatt, Fernando, additional, Luís de Castro Araujo, Bruno, additional, Arbesú, Genaro, additional, Artsi, Hanna, additional, Aurilio, Caterina, additional, Ayanoglu, Omer Hilmi, additional, Baig, Harris, additional, Baird, Yolanda, additional, Balonov, Konstantin, additional, Banks, Samantha, additional, Bao, Xiaodong, additional, Baumgartner, Mélanie, additional, Tortosa, Isabel Belda, additional, Bergamaschi, Alice, additional, Bergmann, Lars, additional, Bigatello, Luca, additional, Pérez, Elena Biosca, additional, Birr, Katja, additional, Bojaxhi, Elird, additional, Bonenti, Chiara, additional, Bonney, Iwona, additional, Bos, Elke M.E., additional, Bowman, Sara, additional, Braz, Leandro Gobbo, additional, Brugnoni, Elisa, additional, Brull, Sorin J., additional, Brunetti, Iole, additional, Bruni, Andrea, additional, Buenvenida, Shonie L., additional, Busch, Cornelius Johannes, additional, Camerini, Giovanni, additional, Capatti, Beatrice, additional, Carmona, Javiera, additional, Carungcong, Jaime, additional, Carvalho, Marta, additional, Cattan, Anat, additional, Cavaleiro, Carla, additional, Chiumello, Davide, additional, Ciardo, Stefano, additional, Coburn, Mark, additional, Colella, Umberto, additional, Contreras, Victor, additional, Dincer, Pelin Corman, additional, Cotter, Elizabeth, additional, Crovetto, Marcia, additional, Darrah, William, additional, Davies, Simon, additional, Del Cojo Peces, Enrique, additional, Delphin, Ellise, additional, Diaper, John, additional, Junior, Paulo do Nascimento, additional, Donatiello, Valerio, additional, Dong, Jing, additional, Dourado, Maria do Socorro, additional, Dullenkopf, Alexander, additional, Ebner, Felix, additional, Elgendy, Hamed, additional, Ellenberger, Christoph, additional, Arı, Dilek Erdoğan, additional, Ermert, Thomas, additional, Farah, Fadi, additional, Fernandez-Bustamante, Ana, additional, Ferreira, Cristina, additional, Fiore, Marco, additional, Fonte, Ana, additional, Palahí, Christina Fortià, additional, Galimberti, Andrea, additional, Garofano, Najia, additional, Giaccari, Luca Gregorio, additional, Gilsanz, Fernando, additional, Girrbach, Felix, additional, Gobbi, Luca, additional, Godfried, Marc Bernard, additional, Goettel, Nicolai, additional, Goldstein, Peter A., additional, Goren, Or, additional, Gorlin, Andrew, additional, Graterol, Juan, additional, Guyon, Pierre, additional, Haire, Kevin, additional, Harou, Philippe, additional, Helf, Antonia, additional, Hempel, Gunther, additional, Hernández Cádiz, María José, additional, Heyse, Björn, additional, Huercio, Ivan, additional, Ilievska, Jasmina, additional, Jakus, Lien, additional, Jeganath, Vijay, additional, Jelting, Yvonne, additional, Jung, Minoa, additional, Kabon, Barbara, additional, Kacha, Aalok, additional, Ilić, Maja Karaman, additional, Karuppiah, Arunthevaraja, additional, Kavas, Ayse Duygu, additional, Barcelos, Gleicy Keli, additional, Kellogg, Todd A., additional, Kemper, Johann, additional, Kerbrat, Romain, additional, Khodr, Suraya, additional, Kienbaum, Peter, additional, Kir, Bunyamin, additional, Kivrak, Selin, additional, Klarić, Vlasta, additional, Köksal, Ceren, additional, Kowark, Ana, additional, Kranke, Peter, additional, Kuvaki, Bahar, additional, Kuzmanovska, Biljana, additional, Laffey, John, additional, Lange, Mirko, additional, Freitas de Lemos, Marília, additional, Licker, Marc-Joseph, additional, López-Baamonde, Manuel, additional, López-Hernández, Antonio, additional, Lopez-Martinez, Mercedes, additional, Luise, Stéphane, additional, MacGregor, Mark, additional, Magalhães, Danielle, additional, Maillard, Julien, additional, Malerbi, Patrizia, additional, Manimekalai, Natesan, additional, Margarson, Michael, additional, Markstaller, Klaus, additional, Martin, Archer K., additional, Martin, David P., additional, Martin, Yvette N., additional, Martínez-Ocon, Julia, additional, Martin-Loeches, Ignacio, additional, Maseda, Emilio, additional, Matot, Idit, additional, McAuliffe, Niamh, additional, McKenzie, Travis J., additional, Medina, Paulina, additional, Meersch, Melanie, additional, Menzen, Angelika, additional, Mertens, Els, additional, Meurer, Bernd, additional, Meyer-Treschan, Tanja, additional, Miao, Changhong, additional, Micalizzi, Camilla, additional, Milić, Morena, additional, Pinheiro Módolo, Norma Sueli, additional, Moine, Pierre, additional, Mölders, Patrick, additional, Montero-Feijoo, Ana, additional, Moret, Enrique, additional, Muller, Markus K., additional, Murphy, Zoe, additional, Nalwaya, Pramod, additional, Naumovski, Filip, additional, Navalesi, Paolo, additional, Navarro e Lima, Lais Helena, additional, Adam, Višnja Nesek, additional, Neumann, Claudia, additional, Newell, Christopher, additional, Nisnevitch, Zoulfira, additional, Nizamuddin, Junaid, additional, Novazzi, Cecilia, additional, O'Connor, Michael, additional, Oprea, Günther, additional, Sungur, Mukadder Orhan, additional, Özbilgin, Şule, additional, Pace, Maria Caterina, additional, Pacheco, Marcos, additional, Packianathaswamy, Balaji, additional, Gonzalez, Estefania Palma, additional, Papaspyros, Fotios, additional, Paredes, Sebastián, additional, Passavanti, Maria Beatrice, additional, Pedemonte, Juan Cristobal, additional, Peremin, Sanja, additional, Philipsenburg, Christoph, additional, Pinho, Daniela, additional, Pinho, Silvia, additional, Posthuma, Linda M., additional, Pota, Vincenzo, additional, Preckel, Benedikt, additional, Priani, Paolo, additional, Rached, Mohamed Aymen, additional, Radoeshki, Aleksandar, additional, Ragazzi, Riccardo, additional, Rajamanickam, Tamilselvan, additional, Rajamohan, Arthi, additional, Ramakrishna, Harish, additional, Rangarajan, Desikan, additional, Reiterer, Christian, additional, Renew, J. Ross, additional, Reynaud, Thomas, additional, Rhys, Rhidian, additional, Rivas, Eva, additional, Robitzky, Luisa, additional, Rossaint, Rolf, additional, Rubulotta, Francesca, additional, Machado, Humberto S., additional, Nunes, Catarina S., additional, Sabbatini, Giovanni, additional, Samuels, Jon D., additional, Sanahuja, Josep Martí, additional, Sansone, Pasquale, additional, Santos, Alice, additional, Sayedalahl, Mohamed, additional, Scharffenberg, Martin, additional, Schiffer, Eduardo, additional, Schliewe, Nadja, additional, Schorer, Raoul, additional, Schumann, Roman, additional, Selmo, Gabriele, additional, Sendra, Mar, additional, Senturk, Mert, additional, Shaw, Kate, additional, Shosholcheva, Mirjana, additional, Sibai, Abdulrazak, additional, Simonassi, Francesca, additional, Sinno, Claudia, additional, Sivrikoz, Nukhet, additional, Skandalou, Vasiliki, additional, Smith, Neil, additional, Soares, Maria, additional, Artiles, Tania Socorro, additional, Castro, Diogo Sousa, additional, Sousa, Miguel, additional, Spadaro, Savino, additional, Stamatakis, Emmanouil, additional, Steiner, Luzius A., additional, Stevenazzi, Andrea, additional, Suarez-de-la-Rica, Alejandro, additional, Suppan, Mélanie, additional, Teichmann, Robert, additional, Tena Guerrero, José Maria, additional, Thiel, Bram, additional, Tolós, Raquel, additional, Altun, Gulbin Tore, additional, Tucci, Michelle, additional, Turnbull, Zachary A., additional, Turudić, Žana, additional, Unterberg, Matthias, additional, Van Nieuwenhove, Yves, additional, Van Waesberghe, Julia, additional, Vidal Melo, Marcos Francisco, additional, Vitković, Bibiana, additional, Vivona, Luigi, additional, Vizcaychipi, Marcela, additional, Volta, Carlo Alberto, additional, Weber, Anne, additional, Weingarten, Toby N., additional, Wittenstein, Jakob, additional, Wyffels, Piet, additional, Yagüe, Julio, additional, Yates, David, additional, Yavru, Ayşen, additional, Zac, Lilach, additional, and Zhong, Jing, additional

Published
2022
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36. Reducing Perioperative Neurocognitive Disorders (PND) Through Depth of Anesthesia Monitoring: A Critical Review

Author

Evered,Lisbeth A and Goldstein,Peter A

Subjects
International Journal of General Medicine
Abstract

Lisbeth A Evered,1– 4 Peter A Goldstein1,4,5 1Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA; 2Department of Anaesthesia and Acute Pain Medicine, St. Vincent’s Hospital, Melbourne, VIC, Australia; 3Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; 4Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA; 5Department of Medicine, Weill Cornell Medicine, New York, NY, USACorrespondence: Peter A GoldsteinDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY 10065, USATel +1-212-746-5325Email pag2014@med.cornell.eduAbstract: General anesthesia has been administered for over 150 years, and in that time, has become progressively safer. Improvements in outcomes have been driven by multiple advances, including the use of non-invasive monitors to assess cardiovascular and respiratory status. More recent advances have included the development and use of monitors to measure neurologic status by means of “processed” electroencephalography (pEEG), wherein the frontal EEG signal is analyzed by proprietary algorithms to produce a dimensionless number (scaled from 0 to 100), wherein low values are associated with deepening levels of sedation that progresses to loss of consciousness. Such monitors have been shown to enable anesthetic titration so as to expedite emergence and early recovery, and their use is advocated for the prevention of intraoperative awareness in the setting of administration of total intravenous anesthesia and neuromuscular blockade. Whether their use can minimize, or prevent, longer term adverse events is a matter of debate. In this narrative review of the most recent literature, we provide an assessment on the use of pEEG monitors in the prevention of a notable, and important, postoperative adverse outcome – delirium – in elderly patients. As we will discuss, the existing data do not support its routine use for the prevention of postoperative delirium in this, or any other, patient population.Keywords: delirium, outcome, postoperative, EEG, electroencephalography

Published
2021

37. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

Author

Lafaille, Fabien G., Pessach, Itai M., Zhang, Shen-Ying, Ciancanelli, Michael J., Herman, Melina, Abhyankar, Avinash, Ying, Shui-Wang, Keros, Sotirios, Goldstein, Peter A., Mostoslavsky, Gustavo, Ordovas-Montanes, Jose, Jouanguy, Emmanuelle, Plancoulaine, Sabine, Tu, Edmund, Elkabetz, Yechiel, Muhsen, Saleh Al-, Tardieu, Marc, Schlaeger, Thorsten M., Daley, George Q., Abel, Laurent, Casanova, Jean-Laurent, Studer, Lorenz, and Notarangelo, Luigi D.

Subjects
Neurons -- Physiological aspects -- Health aspects -- Research, Virulence (Microbiology) -- Research -- Physiological aspects -- Health aspects, Stem cells -- Physiological aspects -- Health aspects -- Research, Herpes simplex virus -- Physiological aspects -- Health aspects -- Research, Toll-like receptors -- Physiological aspects -- Health aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

In the course of primary infection with herpes simplex virus 1 (HSV-1), children with inborn errors of toll-like receptor 3 (TLR3) immunity are prone to HSV-1 encephalitis (HSE) (1-3). We tested the hypothesis that the pathogenesis of HSE involves non-haematopoietic CNS-resident cells. We derived induced pluripotent stem cells (iPSCs) from the dermal fibroblasts of TLR3- and UNC-93B-deficient patients and from controls. These iPSCs were differentiated into highly purified populations of neural stem cells (NSCs), neurons, astrocytes and oligodendrocytes. The induction of interferon-β (IFN-β) and/or IFN-λ1 in response to stimulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependent on TLR3 and UNC-93B in all cells tested. However, the induction of IFN-β and IFN-λ1 in response to HSV-1 infection was impaired selectively in UNC-93B-deficient neurons and oligodendrocytes. These cells were also much more susceptible to HSV-1 infection than control cells, whereas UNC-93B-deficient NSCs and astrocytes were not. TLR3-deficient neurons were also found to be susceptible to HSV-1 infection. The rescue of UNC-93B- and TLR3deficient cells with the corresponding wild-type allele showed that the genetic defect was the cause of the poly(I:C) and HSV-1 phenotypes. The viral infection phenotype was rescued further by treatment with exogenous IFN-a or IFN-β (IFN-α/β) but not IFN-λ1. Thus, impaired TLR3- and UNC-93B-dependent IFN-α/β intrinsic immunity to HSV-1 in the CNS, in neurons and oligodendrocytes in particular, may underlie the pathogenesis of HSE in children with TLR3-pathway deficiencies., Childhood HSE is a rare, life-threatening, central nervous system (CNS)-restricted complication of primary infection with HSV-1, an almost ubiquitous virus that is typically innocuous4. Children with HSE are not unusually [...]

Published
2012
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38. Problems and Solutions

Author

Hunter, J. A. H., Bankoff, Leon, Lind, Douglas, Viertel, William K., Sutcliffe, Alan, Hall, H. Tracy, Demir, Huseyin, Belna, Charles L., Brown, Martin J., Chuck, Joy Ann, Goldstein, Peter, Cormier, R. J., Ng, Wahin, Philpott, Wade E., Rabinowitz, Stanley, Wilder, Donald R., Moon, J. W., Beineke, L. W., Guthery, Scott B., Gehman, Harry M., Duncan, Dewey, Trigg, Charles W., Terry, Fred, Spital, Sidney, Bogue, Cameron, Ivanoff, V. F., Hoffman, Stephen, Bankoff, Leon, Klamkin, Murray S., Carlitz, L., Gemignani, Michael, Ligh, Steve, Pinzka, Charles F., Charosh, Mannis, Silverman, D. L., and Laatsch, Richard

Published
1965
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43. Emerging molecular mechanisms of general anesthetic action

Author

Hemmings, Hugh C., Jr., Akabas, Myles H., Goldstein, Peter A., Trudell, James R., Orser, Beverley A., and Harrison, Neil L.

Subjects
Central nervous system agents -- Research, Central nervous system agents -- Chemical properties, Antineoplastic agents -- Structure-activity relationships, Biological sciences, Chemistry, Pharmaceuticals and cosmetics industries
Abstract

General anesthetics are essential to modern medicine, and yet a detailed understanding of their mechanisms of action is lacking. General anesthetics were once believed to be 'drugs without receptors' but this view has been largely abandoned. During the past decade significant progress in our understanding of the mechanisms of general anesthetic action at the molecular, cellular and neural systems levels has been made. Different molecular targets in various regions of the nervous system are involved in the multiple components of anesthetic action, and these targets can vary between specific anesthetics. Neurotransmitter-gated ion channels, particularly receptors for GABA and glutamate, are modulated by most anesthetics, at both synaptic and extrasynaptic sites, and additional ion channels and receptors are also being recognized as important targets for general anesthetics. In this article, these developments, which have important implications for the development of more-selective anesthetics, are reviewed in the context of recent advances in ion channel structure and function.

Published
2005

44. Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial

Author

Pryor, Kane O., Fahey, Thomas J., III, Lien, Cynthia A., and Goldstein, Peter A.

Subjects
Oxygen therapy -- Health aspects, Surgical wound infections -- Prevention, Surgical wound infections -- Risk factors
Abstract

Giving surgery patients increased oxygen during the operation may not reduce the risk of a surgical wound infection and may even increase the risk, according to a study of 165 patients. One-fourth of the patients who received 80% oxygen developed a surgical wound infection compared to 11% of the patients who received 35% oxygen. Patients who developed a surgical wound infection stayed twice as long in the hospital on average as those who did not.

Published
2004

46. Brief Report –The Current State of Biomedical Ethics Education Among Anesthesiology Training Programs: A Call to Arms

Author

Raymond, Britany L., McEvoy, Matthew D., Goldstein, Peter A., and Drolet, Brian C.

Subjects
Original Research
Abstract

BACKGROUND: Anesthesiology presents unique challenges to the discipline of biomedical ethics, as providers must practice ethical principles under high-stress and time-restricted conditions. The American Board of Anesthesiology has recognized the value of ethical competence through incorporation of ethics-based scenarios on the Advanced and Applied Exams. Accordingly, we performed a needs assessment and gap analysis of the current state of biomedical ethics training among anesthesiology residency programs. METHODS: A survey instrument was formed to assess existing ethics curricula and to identify perceived interest and barriers to integrating a formal ethics curriculum into residency training. The survey was distributed online to anesthesiology residency program directors in the United States. RESULTS: The survey was distributed (N = 150) with a response rate of 53% (n = 79). Half the respondents reported providing formal ethics training in their program, which averaged 3.8 ± 1.6 h/year. Only 58% of respondents agreed that their residents were competent at managing biomedical ethical dilemmas upon graduation. The lack of a preestablished curriculum, knowledgeable faculty, and time were the most cited barriers to providing ethics training. Most respondents expressed interest in using a standardized ethics curriculum if offered by a credible academic society and believed it should be a requirement during training. CONCLUSION: Our needs analysis is reflective of considerable interest among anesthesiology program directors to use a uniform biomedical ethics curriculum for trainees, with a majority (n = 53, 68%) endorsing it as a proposed requirement for graduation.

Published
2019

48. How to diagnose and repair congenital uterovaginal malformations: knowing when and how these abnormalities become apparent is the first step toward correcting them

Author

Goldstein, Peter Donald

Subjects
Agenesis -- Diagnosis -- Care and treatment -- Case studies, Abdominal pain -- Diagnosis -- Care and treatment -- Case studies, Vaginal diseases -- Diagnosis -- Care and treatment -- Case studies
Abstract

CASE 1 Fluid-filled abdominal mass A 14-year-old girl complains of crampy, episodic, lower abdominal pain of 3 months' duration and acute retention of urine. She also reports back pain and […]

Published
2008

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