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2. Entropy removal of medical diagnostics

Author

He, Shuhan, Chong, Paul, Yoon, Byung-Jun, Chung, Pei-Hung, Chen, David, Marzouk, Sammer, Black, Kameron C., Sharp, Wilson, Safari, Pedram, Goldstein, Joshua N., Raja, Ali S., and Lee, Jarone

Published
2024
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5. Accurate super-resolution low-field brain MRI

Author

Iglesias, Juan Eugenio, Schleicher, Riana, Laguna, Sonia, Billot, Benjamin, Schaefer, Pamela, McKaig, Brenna, Goldstein, Joshua N., Sheth, Kevin N., Rosen, Matthew S., and Kimberly, W. Taylor

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

The recent introduction of portable, low-field MRI (LF-MRI) into the clinical setting has the potential to transform neuroimaging. However, LF-MRI is limited by lower resolution and signal-to-noise ratio, leading to incomplete characterization of brain regions. To address this challenge, recent advances in machine learning facilitate the synthesis of higher resolution images derived from one or multiple lower resolution scans. Here, we report the extension of a machine learning super-resolution (SR) algorithm to synthesize 1 mm isotropic MPRAGE-like scans from LF-MRI T1-weighted and T2-weighted sequences. Our initial results on a paired dataset of LF and high-field (HF, 1.5T-3T) clinical scans show that: (i) application of available automated segmentation tools directly to LF-MRI images falters; but (ii) segmentation tools succeed when applied to SR images with high correlation to gold standard measurements from HF-MRI (e.g., r = 0.85 for hippocampal volume, r = 0.84 for the thalamus, r = 0.92 for the whole cerebrum). This work demonstrates proof-of-principle post-processing image enhancement from lower resolution LF-MRI sequences. These results lay the foundation for future work to enhance the detection of normal and abnormal image findings at LF and ultimately improve the diagnostic performance of LF-MRI. Our tools are publicly available on FreeSurfer (surfer.nmr.mgh.harvard.edu/).

Published
2022

7. Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study

Author

Senff, Jasper R., Singh, Sanjula D., Pasi, Marco, Jolink, Wilmar M.T., Rodrigues, Mark A., Schreuder, Floris H.B.M., Staals, Julie, Schreuder, Tobien, Douwes, Jules P.J., Talsma, Jelmer, McKaig, Brenna N., Kourkoulis, Christina, Yechoor, Nirupama, Anderson, Christopher D., Puy, Laurent, Cordonnier, Charlotte, Wermer, Marieke J.H., Rothwell, Peter M., Rosand, Jonathan, Klijn, Catharina J.M., Al-Shahi Salman, Rustam, Rinkel, Gabriël J.E., Viswanathan, Anand, Goldstein, Joshua N., and Brouwers, H. Bart

Published
2024
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9. Code ICH: A Call to Action

Author

Li, Qi, Yakhkind, Aleksandra, Alexandrov, Anne W., Alexandrov, Andrei V., Anderson, Craig S., Dowlatshahi, Dar, Frontera, Jennifer A., Hemphill, J. Claude, Ganti, Latha, Kellner, Chris, May, Casey, Morotti, Andrea, Parry-Jones, Adrian, Sheth, Kevin N., Steiner, Thorsten, Ziai, Wendy, Goldstein, Joshua N., and Mayer, Stephan A.

Published
2024
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11. Impact of Emergency Department Crowding on Delays in Acute Stroke Care

Author

Jaffe, Todd A., Goldstein, Joshua N., Yun, Brian J., Etherton, Mark, Leslie-Mazwi, Thabele, Schwamm, Lee H., and Zachrison, Kori S.

Subjects
Emergency Department Crowding, Stroke, Endovascular Therapy
Abstract

Introduction: Delays in identification and treatment of acute stroke contribute to significant morbidity and mortality. Multiple clinical factors have been associated with delays in acute stroke care. We aimed to determine the relationship between emergency department (ED) crowding and the delivery of timely emergency stroke care.Methods: We used prospectively collected data from our institutional Get with the Guidelines-Stroke registry to identify consecutive acute ischemic stroke patients presenting to our urban academic ED from July 2016–August 2018. We used capacity logs to determine the degree of ED crowding at the time of patients’ presentation and classified them as ordinal variables (normal, high, and severe capacity constraints). Outcomes of interest were door-to-imaging time (DIT) among patients potentially eligible for alteplase or endovascular therapy on presentation, door-to-needle time (DTN) for alteplase delivery, and door-to-groin puncture (DTP) times for endovascular therapy. Bivariate comparisons were made using t-tests, chi-square, and Wilcoxon rank-sum tests as appropriate. We used regression models to examine the relationship after accounting for patient demographics, transfer status, arrival mode, and initial stroke severity by the National Institutes of Health Stroke Scale.Results: Of the 1379 patients with ischemic stroke presenting during the study period, 1081 (78%) presented at times of normal capacity, 203 (15%) during high ED crowding, and 94 (7%) during severe crowding. Median DIT was 26 minutes (interquartile range [IQR] 17-52); DTN time was 43 minutes (IQR 31-59); and median DTP was 58.5 minutes (IQR 56.5-100). Treatment times were not significantly different during periods of higher ED utilization in bivariate or in multivariable testing.Conclusion: In our single institution analysis, we found no significant delays in stroke care delivery associated with increased ED crowding. This finding suggests that robust processes of care may enable continued high-quality acute care delivery, even during times with an increased capacity burden.

Published
2020

15. Thromboembolic Risk of 4 Factor Prothrombin Complex Concentrate versus Fresh Frozen Plasma for Urgent Warfarin Reversal in the Emergency Department

Author

Maguire, Michelle, Fuh, Lanting, Goldstein, Joshua N., Marshall, Ariela L., Levine, Michael, Howell, Melissa L., Parry, Blair A., Rosovsky, Rachel, and Hayes, Bryan D.

Subjects
Emergency medicine
Abstract

Introduction: Warfarin is a potent anticoagulant used for the prevention and treatment of venous and arterial thrombosis. Occasionally, patients require emergent warfarin reversal due to active bleeding, supratherapeutic international normalized ratio, or emergent diagnostic or therapeutic interventions. Various agents can be used for emergent warfarin reversal, including fresh frozen plasma (FFP) and 4-factor prothrombin complex concentrate (4F-PCC). Both FFP and 4F-PCC are generally considered safe; however, both agents contain coagulation factors and have the potential to provoke a thromboembolic event. Although clinical trials have compared the efficacy and safety of FFP and 4F-PCC, data are limited comparing the risk of thromboembolism between the two agents.Methods: A retrospective chart review was performed at a single, urban, academic medical center comparing the incidence of thromboembolism with FFP or 4F-PCC for warfarin reversal during a three-year period in the emergency department (ED) at Massachusetts General Hospital. Patients were included in the study if they were at least 18 years of age and were on warfarin per electronic health records. Patients were excluded if they had received both FFP and 4F-PCC during the same visit. The primary outcome was the frequency of thromboembolism within 30 days of 4F-PCC or FFP. Secondary outcomes included time to thromboembolic event and in-hospital mortality.Results: Three hundred and thirty-six patients met the inclusion criteria. Thromboembolic events within 30 days of therapy occurred in seven patients (2.7%) in the FFP group and 14 patients (17.7%) in the 4F-PCC group (p=

Published
2019

17. A targetable ‘rogue’ neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS

Author

Herrera, Victoria L. M., Walkey, Allan J., Nguyen, Mai Q., Gromisch, Christopher M., Mosaddhegi, Julie Z., Gromisch, Matthew S., Jundi, Bakr, Lukassen, Soeren, Carstensen, Saskia, Denis, Ridiane, Belkina, Anna C., Baron, Rebecca M., Pinilla-Vera, Mayra, Mueller, Meike, Kimberly, W. Taylor, Goldstein, Joshua N., Lehmann, Irina, Shih, Angela R., Eils, Roland, Levy, Bruce D., and Ruiz-Opazo, Nelson

Published
2022
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19. Intensive Blood Pressure Lowering and DWI Lesions in Intracerebral Hemorrhage: Exploratory Analysis of the ATACH-2 Randomized Trial

Author

Shoamanesh, Ashkan, Cassarly, Christy, Morotti, Andrea, Romero, Javier M., Oliveira-Filho, Jamary, Schlunk, Frieder, Jessel, Michael, Butcher, Kenneth, Gioia, Laura, Ayres, Alison, Vashkevich, Anastasia, Schwab, Kristin, Afzal, Mohammad Rauf, Martin, Renee H., Qureshi, Adnan I., Greenberg, Steven M., Rosand, Jonathan, and Goldstein, Joshua N.

Published
2022
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21. Impact of a Pharmacist-Driven Prothrombin Complex Concentrate Protocol on Time to Administration in Patients with Warfarin-associated Intracranial Hemorrhage

Author

Corio, Jessica L., Sin, Jonathan H., Hayes, Bryan D., Goldstein, Joshua N., and Fuh, Lanting

Subjects
pharmacist-driven protocol, warfarin reversal, four-factor prothrombin complete concentrate
Abstract

Introduction: Advancements in the treatment of warfarin-associated intracranial hemorrhage (ICH) include the use of four-factor prothrombin complex concentrate (4F-PCC), which has demonstrated more rapid reversal of the international normalized ratio (INR) when compared with fresh frozen plasma. A pharmacist-driven protocol for 4F-PCC was implemented within our institution, which allows for pharmacist approval of 4F-PCC in patients diagnosed with warfarin-associated ICH and an INR ≥2. The pharmacist is responsible for determining the appropriate dose of 4F-PCC, preparation, bedside delivery, and order entry into the electronic medical record. Prior to implementation of the new protocol, the blood bank was responsible for 4F-PCC approval, dosing, product preparation, and arranging delivery with emergency department (ED) staff. The purpose of this study was to evaluate the impact of a pharmacist-driven protocol on time to 4F-PCC administration in warfarin-associated ICH. Methods: We performed a retrospective review of consecutive patients who received 4F-PCC in a single ED from September 2015 through February 2017. Patients ≥18 years old were eligible for inclusion based on three criteria: confirmed diagnosis of ICH; confirmed warfarin use; and INR ≥2. Secondary outcomes included dose of 4F-PCC in concordance with INR and weight-based dosing recommendations and hospital protocol, as well as concomitant intravenous vitamin K administration.  Results: A total of 48 patients met inclusion criteria for the study with 24 patients in each protocol group. The median time to administration of 4F-PCC in the pharmacist-driven protocol group was 35 minutes (interquartile range [IQR] [25-62]; range, 11-133) compared with 70 minutes (IQR [34-89]; range, 14-244) in the pre-protocol group (p=0.034). We saw no differences for appropriate 4F-PCC dosing based on INR and patient weight between the two groups.  Conclusion: Implementation of a pharmacist-driven protocol for 4F-PCC in the ED at our institution significantly reduced time to administration in patients presenting with warfarin-associated ICH.

Published
2018

22. Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients

Author

Sorby‐Adams, Annabel, primary, Guo, Jennifer, additional, de Havenon, Adam, additional, Payabvash, Seyedmehdi, additional, Sze, Gordon, additional, Pinter, Nandor K., additional, Jaikumar, Vinay, additional, Siddiqui, Adnan, additional, Baldassano, Steven, additional, Garcia‐Guarniz, Ana‐Lucia, additional, Zabinska, Julia, additional, Lalwani, Dheeraj, additional, Peasley, Emma, additional, Goldstein, Joshua N., additional, Nelson, Olivia K., additional, Schaefer, Pamela W., additional, Wira, Charles R., additional, Pitts, John, additional, Lee, Vivien, additional, Muir, Keith W., additional, Nimjee, Shahid M., additional, Kirsch, John, additional, Iglesias, Juan Eugenio, additional, Rosen, Matthew S., additional, Sheth, Kevin N., additional, and Kimberly, W. Taylor, additional

Published
2024
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24. Phantom-based standardization of CT angiography images for spot sign detection

Author

Morotti, Andrea, Romero, Javier M, Jessel, Michael J, Hernandez, Andrew M, Vashkevich, Anastasia, Schwab, Kristin, Burns, Joseph D, Shah, Qaisar A, Bergman, Thomas A, Suri, M Fareed K, Ezzeddine, Mustapha, Kirmani, Jawad F, Agarwal, Sachin, Shapshak, Angela Hays, Messe, Steven R, Venkatasubramanian, Chitra, Palmieri, Katherine, Lewandowski, Christopher, Chang, Tiffany R, Chang, Ira, Rose, David Z, Smith, Wade, Hsu, Chung Y, Liu, Chun-Lin, Lien, Li-Ming, Hsiao, Chen-Yu, Iwama, Toru, Afzal, Mohammad Rauf, Cassarly, Christy, Greenberg, Steven M, Martin, Renee’ Hebert, Qureshi, Adnan I, Rosand, Jonathan, Boone, John M, Goldstein, Joshua N, and On Behalf of ATACH-II and NETT Investigators

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Stroke, Biomedical Imaging, Bioengineering, Clinical Trials and Supportive Activities, Clinical Research, Calibration, Cerebral Hemorrhage, Computed Tomography Angiography, Hematoma, Humans, Iodine, Phantoms, Imaging, Sensitivity and Specificity, Software, Intracerebral hemorrhage, Spot sign, CT angiography, Phantom standardization, ATACH-II and NETT Investigators, Neurosciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

PurposeThe CT angiography (CTA) spot sign is a strong predictor of hematoma expansion in intracerebral hemorrhage (ICH). However, CTA parameters vary widely across centers and may negatively impact spot sign accuracy in predicting ICH expansion. We developed a CT iodine calibration phantom that was scanned at different institutions in a large multicenter ICH clinical trial to determine the effect of image standardization on spot sign detection and performance.MethodsA custom phantom containing known concentrations of iodine was designed and scanned using the stroke CT protocol at each institution. Custom software was developed to read the CT volume datasets and calculate the Hounsfield unit as a function of iodine concentration for each phantom scan. CTA images obtained within 8 h from symptom onset were analyzed by two trained readers comparing the calibrated vs. uncalibrated density cutoffs for spot sign identification. ICH expansion was defined as hematoma volume growth >33%.ResultsA total of 90 subjects qualified for the study, of whom 17/83 (20.5%) experienced ICH expansion. The number of spot sign positive scans was higher in the calibrated analysis (67.8 vs 38.9% p

Published
2017

25. Long-Term Outcomes in Patients with Spontaneous Cerebellar Hemorrhage: An International Cohort Study

Author

Projectafdeling CVZ, MS CGO, Neurologen, Brain, Circulatory Health, Neurochirurgie, Senff, Jasper R., Singh, Sanjula D., Pasi, Marco, Jolink, Wilmar M.T., Rodrigues, Mark A., Schreuder, Floris H.B.M., Staals, Julie, Schreuder, Tobien, Douwes, Jules P.J., Talsma, Jelmer, McKaig, Brenna N., Kourkoulis, Christina, Yechoor, Nirupama, Anderson, Christopher D., Puy, Laurent, Cordonnier, Charlotte, Wermer, Marieke J.H., Rothwell, Peter M., Rosand, Jonathan, Klijn, Catharina J.M., Al-Shahi Salman, Rustam, Rinkel, Gabriël J.E., Viswanathan, Anand, Goldstein, Joshua N., Brouwers, H. Bart, Projectafdeling CVZ, MS CGO, Neurologen, Brain, Circulatory Health, Neurochirurgie, Senff, Jasper R., Singh, Sanjula D., Pasi, Marco, Jolink, Wilmar M.T., Rodrigues, Mark A., Schreuder, Floris H.B.M., Staals, Julie, Schreuder, Tobien, Douwes, Jules P.J., Talsma, Jelmer, McKaig, Brenna N., Kourkoulis, Christina, Yechoor, Nirupama, Anderson, Christopher D., Puy, Laurent, Cordonnier, Charlotte, Wermer, Marieke J.H., Rothwell, Peter M., Rosand, Jonathan, Klijn, Catharina J.M., Al-Shahi Salman, Rustam, Rinkel, Gabriël J.E., Viswanathan, Anand, Goldstein, Joshua N., and Brouwers, H. Bart

Published
2024

26. Hypotension During Vasopressor Infusion Occurs in Predictable Clusters: A Multicenter Analysis.

Author

Horiguchi, Daisuke, Shin, Sungtae, Pepino, Jeremy A., Peterson, Jeffrey T., Kehoe, Iain E., Goldstein, Joshua N., Lee, Jarone, Kwon, Brian K., Hahn, Jin-Oh, and Reisner, Andrew T.

Subjects
HYPOTENSION, VASOCONSTRICTORS, SPINAL cord injuries, INTENSIVE care units, ARTERIAL pressure
Abstract

Background: Published evidence indicates that mean arterial pressure (MAP) below a goal range (hypotension) is associated with worse outcomes, though MAP management failures are common. We sought to characterize hypotension occurrences in ICUs and consider the implications for MAP management. Methods: Retrospective analysis of 3 hospitals' cohorts of adult ICU patients during continuous vasopressor infusion. Two cohorts were general, mixed ICU patients and one was exclusively acute spinal cord injury patients. "Hypotension-clusters" were defined where there were ≥10 min of cumulative hypotension over a 60-min period and "constant hypotension" was ≥10 continuous minutes. Trend analysis was performed (predicting future MAP using 14 min of preceding MAP data) to understand which hypotension-clusters could likely have been predicted by clinician awareness of MAP trends. Results: In cohorts of 155, 66, and 16 ICU stays, respectively, the majority of hypotension occurred within the hypotension-clusters. Failures to keep MAP above the hypotension threshold were notable in the bottom quartiles of each cohort, with hypotension durations of 436, 167, and 468 min, respectively, occurring within hypotension-clusters per day. Mean arterial pressure trend analysis identified most hypotension-clusters before any constant hypotension occurred (81.2%-93.6% sensitivity, range). The positive predictive value of hypotension predictions ranged from 51.4% to 72.9%. Conclusions: Across 3 cohorts, most hypotension occurred in temporal clusters of hypotension that were usually predictable from extrapolation of MAP trends. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Cerebral Small Vessel Diseases and Sleep Related Strokes

Author

Lauer, Arne, Ay, Hakan, Bianchi, Matt, Charidimou, Andreas, Boulouis, Gregoire, Ayres, Alison, Vashkevich, Anastasia, Schwab, Kristin M., Singhal, Aneesh B., Viswanathan, Anand, Rost, Natalia S., Goldstein, Joshua N., Rosand, Jonathan, Schwamm, Lee H., Greenberg, Steven M., and Gurol, Mahmut Edip

Published
2020
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32. Abstract 128: Multi-Direction Diffusion Weighted Imaging on Portable, Low-Field Magnetic Resonance Imaging

Author

Sorby-Adams, Annabel, primary, Kirsch, John, additional, Guo, Jennifer, additional, Nelson, Olivia, additional, Goldstein, Joshua N, additional, Pitts, John, additional, O'Halloran, Rafael, additional, Schaefer, Pamela, additional, Rapalino, Otto, additional, Rosen, Matthew, additional, Iglesias, Juan Eugenio, additional, Sheth, Kevin N, additional, and Kimberly, W. Taylor, additional

Published
2024
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34. Abstract 145: Anticoagulation-Related Intracerebral Hemorrhage and Time to Reversal Treatment After Intracerebral Hemorrhage in the United States

Author

Sheth, Kevin N, primary, Solomon, Nicole, additional, Alhanti, Brooke, additional, Messe, Steven, additional, Xian, Ying, additional, Bhatt, Deepak, additional, Hemphill, Claude C, additional, Frontera, Jennifer, additional, CHANG, RAY, additional, Danelich, Ilya, additional, Huang, Joanna, additional, Schwamm, Lee H, additional, Smith, Eric E, additional, Goldstein, Joshua N, additional, MacGrory, Brian, additional, Fonarow, Gregg C, additional, and Saver, Jeffrey, additional

Published
2024
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35. Abstract TMP74: Association Between Hematoma Volume After Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis

Author

Harris, William, primary, Kaiser, Jed, additional, Avadhani, Radhika, additional, Iadecola, Costantino, additional, Sheth, Kevin N, additional, Awad, Issam, additional, Goldstein, Joshua N, additional, Qureshi, Adnan I, additional, Hanley, Daniel F, additional, Kamel, Hooman, additional, Ziai, Wendy C, additional, and Murthy, Santosh B, additional

Published
2024
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36. Predicting Intracerebral Hemorrhage Growth With the Spot Sign

Author

Dowlatshahi, Dar, Brouwers, H Bart, Demchuk, Andrew M, Hill, Michael D, Aviv, Richard I, Ufholz, Lee-Anne, Reaume, Michael, Wintermark, Max, Hemphill, J Claude, Murai, Yasuo, Wang, Yongjun, Zhao, Xingquan, Wang, Yilong, Li, Na, Sorimachi, Takatoshi, Matsumae, Mitsunori, Steiner, Thorsten, Rizos, Timolaos, Greenberg, Steven M, Romero, Javier M, Rosand, Jonathan, Goldstein, Joshua N, and Sharma, Mukul

Subjects
Biomedical Imaging, Stroke, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Cerebral Angiography, Cerebral Hemorrhage, Disease Progression, Hematoma, Humans, Predictive Value of Tests, Time Factors, Tomography, X-Ray Computed, cerebral hemorrhage, hematoma expansion, CT angiography, spot sign, intracerebral hemorrhage, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

Background and purposeHematoma expansion after acute intracerebral hemorrhage is common and is associated with early deterioration and poor clinical outcome. The computed tomographic angiography (CTA) spot sign is a promising predictor of expansion; however, frequency and predictive values are variable across studies, possibly because of differences in onset-to-CTA time. We performed a patient-level meta-analysis to define the relationship between onset-to-CTA time and frequency and predictive ability of the spot sign.MethodsWe completed a systematic review for studies of CTA spot sign and hematoma expansion. We subsequently pooled patient-level data on the frequency and predictive values for significant hematoma expansion according to 5 predefined categorized onset-to-CTA times. We calculated spot-sign frequency both as raw and frequency-adjusted rates.ResultsAmong 2051 studies identified, 12 met our inclusion criteria. Baseline hematoma volume, spot-sign status, and time-to-CTA were available for 1176 patients, and 1039 patients had follow-up computed tomographies for hematoma expansion analysis. The overall spot sign frequency was 26%, decreasing from 39% within 2 hours of onset to 13% beyond 8 hours (P

Published
2016

37. Acute care bundles should be used for patients with intracerebral haemorrhage: An expert consensus statement

Author

Parry-Jones, Adrian R, primary, Järhult, Susann J, additional, Kreitzer, Natalie, additional, Morotti, Andrea, additional, Toni, Danilo, additional, Seiffge, David, additional, Mendelow, Alexander David, additional, Patel, Hiren, additional, Brouwers, Hens Bart, additional, Klijn, Catharina JM, additional, Steiner, Thorsten, additional, Gibler, Walter Brian, additional, and Goldstein, Joshua N, additional

Published
2023
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43. Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage

Author

Li, Yunke, primary, Cho, Sung-Min, additional, Avadhani, Radhika, additional, Ali, Hassan, additional, Hao, Yi, additional, Murthy, Santosh B, additional, Goldstein, Joshua N, additional, Xia, Fan, additional, Hu, Xin, additional, Ullman, Natalie L, additional, Awad, Issam, additional, Hanley, Daniel, additional, and Ziai, Wendy C, additional

Published
2023
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44. Association Between Hematoma Expansion Severity and Outcome and Its Interaction With Baseline Intracerebral Hemorrhage Volume

Author

Morotti, Andrea, primary, Boulouis, Gregoire, additional, Nawabi, Jawed, additional, Li, Qi, additional, Charidimou, Andreas, additional, Pasi, Marco, additional, Schlunk, Frieder, additional, Shoamanesh, Ashkan, additional, Katsanos, Aristeidis H., additional, Mazzacane, Federico, additional, Busto, Giorgio, additional, Arba, Francesco, additional, Brancaleoni, Laura, additional, Giacomozzi, Sebastiano, additional, Simonetti, Luigi, additional, Warren, Andrew D., additional, Laudisi, Michele, additional, Cavallini, Anna, additional, Gurol, M. Edip, additional, Viswanathan, Anand, additional, Zini, Andrea, additional, Casetta, Ilaria, additional, Fainardi, Enrico, additional, Greenberg, Steven M., additional, Padovani, Alessandro, additional, Rosand, Jonathan, additional, and Goldstein, Joshua N., additional

Published
2023
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45. Intensive Blood Pressure Reduction is Associated with Reduced Hematoma Growth in Fast Bleeding Intracerebral Hemorrhage A Secondary Analysis of the ATACH‐2 Randomized Clinical Trial

Author

Li, Qi, primary, Morotti, Andrea, additional, Warren, Andrew, additional, Qureshi, Adnan I, additional, Dowlatshahi, Dar, additional, Falcone, Guido, additional, Sheth, Kevin N., additional, Shoamanesh, Ashkan, additional, Murthy, Santosh B., additional, Viswanathan, Anand, additional, and Goldstein, Joshua N., additional

Published
2023
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46. Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data

Author

Hanley, Daniel F, Jr, Butcher, Kenneth S, Davis, Stephen, Gregson, Barbara, Lees, Kennedy R, Lyden, Patrick D, Mayer, Stephan A, Muir, Keith W, Steiner, Thorsten, Xie, Peng, Bakhshayesh, Babak, McDonald, Mark, Brott, Thomas, Pennati, Paolo, Parry-Jones, Adrian R, Smith, Craig J, Hopkins, Stephen J, Slevin, Mark, Campi, Veronica, Singh, Puneetpal, Papa, Francesca, Popa-Wagner, Aurel, Tudorica, Valeria, Takagi, Ryo, Teramoto, Akira, Weissenborn, Karin, Lanfermann, Heinrich, Al-Shahi Salman, Rustam, Frantzias, Joseph, Lee, Robert J, Battey, Thomas W K, Ayres, Alison M, Goldstein, Joshua N, Wang, Xia, Arima, Hisatomi, Hasegawa, Hitoshi, Oishi, Makoto, Godoy, Daniel A, Masotti, Luca, Dowlatshahi, Dar, Rodriguez-Luna, David, Molina, Carlos A, Jang, Dong-Kyu, Davalos, Antonio, Castillo, José, Yao, Xiaoying, Claassen, Jan, Volbers, Bastian, Kazui, Seiji, Okada, Yasushi, Fujimoto, Shigeru, Toyoda, Kazunori, Li, Qi, Khoury, Jane, Delgado, Pilar, Sabín, José Álvarez, Hernández-Guillamon, Mar, Prats-Sánchez, Luis, Cai, Chunyan, Kate, Mahesh P, McCourt, Rebecca, Venkatasubramanian, Chitra, Diringer, Michael N, Ikeda, Yukio, Worthmann, Hans, Ziai, Wendy C, d'Esterre, Christopher D, Aviv, Richard I, Raab, Peter, Murai, Yasuo, Zazulia, Allyson R, Seyedsaadat, Seyed Mohammad, Grotta, James C, Martí-Fàbregas, Joan, Montaner, Joan, Broderick, Joseph, Yamamoto, Haruko, Staykov, Dimitre, Connolly, E Sander, Selim, Magdy, Leira, Rogelio, Moon, Byung Hoo, Demchuk, Andrew M, Di Napoli, Mario, Fujii, Yukihiko, Anderson, Craig S, and Rosand, Jonathan

Published
2018
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