1,136 results on '"Goldstein, Joseph L."'
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2. How theJCI's most-cited paper sparked the field of lipoprotein research
3. Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol
4. Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine
5. Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing
6. The boogie-woogie approach to creativity in art and science.
7. Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice
8. How the JCI’s most-cited paper sparked the field of lipoprotein research
9. Phosphorylation of Insig-2 mediates inhibition of fatty acid synthesis by polyunsaturated fatty acids.
10. Akira Endo, who discovered a "penicillin" for heart attacks (1933 to 2024).
11. The Target of Ezetimibe Is Niemann-Pick C1-Like 1 (NPC1L1)
12. Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking Pcsk9
13. Intramembrane Aspartic Acid in SCAP Protein Governs Cholesterol-Induced Conformational Change
14. Central Role for Liver X Receptor in Insulin-Mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver
15. The secret to a successful career in science—according to Magritte
16. Disruption of Hepatitis C Virus RNA Replication through Inhibition of Host Protein Geranylgeranylation
17. Combined Analysis of Oligonucleotide Microarray Data from Transgenic and Knockout Mice Identifies Direct SREBP Target Genes
18. Cholesterol-Induced Conformational Change in SCAP Enhanced by Insig Proteins and Mimicked by Cationic Amphiphiles
19. Liver-Specific mRNA for Insig-2 Down-Regulated by Insulin: Implications for Fatty Acid Synthesis
20. Structure of the LDL Receptor Extracellular Domain at Endosomal pH
21. Insig-2, a Second Endoplasmic Reticulum Protein That Binds SCAP and Blocks Export of Sterol Regulatory Element-Binding Proteins
22. Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis
23. Decreased Lipid Synthesis in Livers of Mice with Disrupted Site-1 Protease Gene
24. Unsaturated Fatty Acids Inhibit Transcription of the Sterol Regulatory Element-Binding Protein-1c (SREBP-1c) Gene by Antagonizing Ligand-Dependent Activation of the LXR
25. Insulin Inhibits Transcription of IRS-2 Gene in Rat Liver through an Insulin Response Element (IRE) That Resembles IREs of Other Insulin-Repressed Genes
26. Expression of Sterol Regulatory Element-Binding Protein 1c (SREBP-1c) mRNA in Rat Hepatoma Cells Requires Endogenous LXR Ligands
27. Asparagine-Proline Sequence within Membrane-Spanning Segment of SREBP Triggers Intramembrane Cleavage by Site-2 Protease
28. Insulin Selectively Increases SREBP-1c mRNA in the Livers of Rats with Streptozotocin-Induced Diabetes
29. Sterols Regulate Processing of Carbohydrate Chains of Wild-Type SREBP Cleavage-Activating Protein (SCAP), but not Sterol-Resistant Mutants Y298C or D443N
30. Cholesterol Feeding Reduces Nuclear Forms of Sterol Regulatory Element Binding Proteins in Hamster Liver
31. Sphingomyelin Depletion in Cultured Cells Blocks Proteolysis of Sterol Regulatory Element Binding Proteins at Site 1
32. Recurrent G-to-A Substitution in a Single Codon of SREBP Cleavage-Activating Protein Causes Sterol Resistance in Three Mutant Chinese Hamster Ovary Cell Lines
33. Purification and cDNA Cloning of a Second Apoptosis-Related Cysteine Protease that Cleaves and Activates Sterol Regulatory Element Binding Proteins
34. Resistance of K-RasB V12 Proteins to Farnesyltransferase Inhibitors in Rat1 Cells
35. Triazoles inhibit cholesterol export from lysosomes by binding to NPC1
36. Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS
37. Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex
38. A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
39. Lowering LDL: Not Only How Low, but How Long?
40. Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet
41. Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice : Reversal by growth hormone
42. The Cholesterol Quartet
43. The art and science of building castles in the sky and houses of cards that don’t collapse
44. Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi
45. Use of mutant ¹²⁵I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells
46. A Golden Era of Nobel Laureates
47. Insulin Stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
48. Scientific Side Trips: Six Excursions from the Beaten Path
49. Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids
50. Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice
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