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5. Cover

Author

Goldstein, David S.

Published
2006

7. Preface

Author

Goldstein, David S.

Published
2006

10. 6 Distress

Author

Goldstein, David S.

Published
2006

16. References

Author

Goldstein, David S.

Published
2006

19. Glossary

Author

Goldstein, David S.

Published
2006

20. Index

Author

Goldstein, David S.

Published
2006

21. Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome

Author

Walitt, Brian, Singh, Komudi, LaMunion, Samuel R., Hallett, Mark, Jacobson, Steve, Chen, Kong, Enose-Akahata, Yoshimi, Apps, Richard, Barb, Jennifer J., Bedard, Patrick, Brychta, Robert J., Buckley, Ashura Williams, Burbelo, Peter D., Calco, Brice, Cathay, Brianna, Chen, Li, Chigurupati, Snigdha, Chen, Jinguo, Cheung, Foo, Chin, Lisa M. K., Coleman, Benjamin W., Courville, Amber B., Deming, Madeleine S., Drinkard, Bart, Feng, Li Rebekah, Ferrucci, Luigi, Gabel, Scott A., Gavin, Angelique, Goldstein, David S., Hassanzadeh, Shahin, Horan, Sean C., Horovitz, Silvina G., Johnson, Kory R., Govan, Anita Jones, Knutson, Kristine M., Kreskow, Joy D., Levin, Mark, Lyons, Jonathan J., Madian, Nicholas, Malik, Nasir, Mammen, Andrew L., McCulloch, John A., McGurrin, Patrick M., Milner, Joshua D., Moaddel, Ruin, Mueller, Geoffrey A., Mukherjee, Amrita, Muñoz-Braceras, Sandra, Norato, Gina, Pak, Katherine, Pinal-Fernandez, Iago, Popa, Traian, Reoma, Lauren B., Sack, Michael N., Safavi, Farinaz, Saligan, Leorey N., Sellers, Brian A., Sinclair, Stephen, Smith, Bryan, Snow, Joseph, Solin, Stacey, Stussman, Barbara J., Trinchieri, Giorgio, Turner, Sara A., Vetter, C. Stephenie, Vial, Felipe, Vizioli, Carlotta, Williams, Ashley, Yang, Shanna B., and Nath, Avindra

Published
2024
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25. Index

Author

Goldstein, David S. and Thacker, Audrey B.

Published
2007

26. Cover

Author

Goldstein, David S. and Thacker, Audrey B.

Published
2007

27. Frontmatter

Author

Goldstein, David S. and Thacker, Audrey B.

Published
2007

39. Acknowledgments

Author

Goldstein, David S. and Thacker, Audrey B.

Published
2007

47. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups.

Author

Kaivola, Karri, Shah, Zalak, Chia, Ruth, Black, Sandra E, Gan-Or, Ziv, Keith, Julia, Masellis, Mario, Rogaeva, Ekaterina, Brice, Alexis, Lesage, Suzanne, Xiromerisiou, Georgia, Calvo, Andrea, Canosa, Antonio, Chio, Adriano, Logroscino, Giancarlo, Mora, Gabriele, Krüger, Reijko, May, Patrick, Alcolea, Daniel, Clarimon, Jordi, Fortea, Juan, Gonzalez-Aramburu, Isabel, Infante, Jon, Lage, Carmen, Lleó, Alberto, Pastor, Pau, Sanchez-Juan, Pascual, Brett, Francesca, Aarsland, Dag, Al-Sarraj, Safa, Attems, Johannes, Gentleman, Steve, Hardy, John A, Hodges, Angela K, Love, Seth, McKeith, Ian G, Morris, Christopher M, Morris, Huw R, Palmer, Laura, Pickering-Brown, Stuart, Ryten, Mina, Thomas, Alan J, Troakes, Claire, Albert, Marilyn S, Barrett, Matthew J, Beach, Thomas G, Bekris, Lynn M, Bennett, David A, Boeve, Bradley F, Dalgard, Clifton L, Dawson, Ted M, Dickson, Dennis W, Faber, Kelley, Ferman, Tanis, Ferrucci, Luigi, Flanagan, Margaret E, Foroud, Tatiana M, Ghetti, Bernardino, Gibbs, J Raphael, Goate, Alison, Goldstein, David S, Graff-Radford, Neill R, Kaufmann, Horacio, Kukull, Walter A, Leverenz, James B, Mao, Qinwen, Masliah, Eliezer, Monuki, Edwin, Newell, Kathy L, Palma, Jose Alberto, Pletnikova, Olga, Renton, Alan E, Resnick, Susan M, Rosenthal, Liana S, Ross, Owen A, Scherzer, Clemens R, Serrano, Geidy E, Shakkottai, Vikram G, Sidransky, Ellen, Tanaka, Toshiko, Topol, Eric, Torkamani, Ali, Troncoso, Juan C, Woltjer, Randy, Wszolek, Zbigniew K, and Scholz, Sonja W

Subjects
Genetics, Lewy Body Dementia, Neurodegenerative, Aging, Brain Disorders, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Alzheimer's Disease, Acquired Cognitive Impairment, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Neurological, Aged, Alzheimer Disease, Apolipoprotein E4, Genome-Wide Association Study, Humans, Lewy Body Disease, alpha-Synuclein, International LBD Genomics Consortium, APOE, Alzheimer’s disease, co-pathology, dementia with Lewy bodies, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

The APOE locus is strongly associated with risk for developing Alzheimer's disease and dementia with Lewy bodies. In particular, the role of the APOE ε4 allele as a putative driver of α-synuclein pathology is a topic of intense debate. Here, we performed a comprehensive evaluation in 2466 dementia with Lewy bodies cases versus 2928 neurologically healthy, aged controls. Using an APOE-stratified genome-wide association study approach, we found that GBA is associated with risk for dementia with Lewy bodies in patients without APOE ε4 (P = 6.58 × 10-9, OR = 3.41, 95% CI = 2.25-5.17), but not with dementia with Lewy bodies with APOE ε4 (P = 0.034, OR = 1.87, 95%, 95% CI = 1.05-3.37). We then divided 495 neuropathologically examined dementia with Lewy bodies cases into three groups based on the extent of concomitant Alzheimer's disease co-pathology: pure dementia with Lewy bodies (n = 88), dementia with Lewy bodies with intermediate Alzheimer's disease co-pathology (n = 66) and dementia with Lewy bodies with high Alzheimer's disease co-pathology (n = 341). In each group, we tested the association of the APOE ε4 against the 2928 neurologically healthy controls. Our examination found that APOE ε4 was associated with dementia with Lewy bodies + Alzheimer's disease (P = 1.29 × 10-32, OR = 4.25, 95% CI = 3.35-5.39) and dementia with Lewy bodies + intermediate Alzheimer's disease (P = 0.0011, OR = 2.31, 95% CI = 1.40-3.83), but not with pure dementia with Lewy bodies (P = 0.31, OR = 0.75, 95% CI = 0.43-1.30). In conclusion, although deep clinical data were not available for these samples, our findings do not support the notion that APOE ε4 is an independent driver of α-synuclein pathology in pure dementia with Lewy bodies, but rather implicate GBA as the main risk gene for the pure dementia with Lewy bodies subgroup.

Published
2022

48. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop

Author

Mehra, Reena, Tjurmina, Olga A, Ajijola, Olujimi A, Arora, Rishi, Bolser, Donald C, Chapleau, Mark W, Chen, Peng-Sheng, Clancy, Colleen E, Delisle, Brian P, Gold, Michael R, Goldberger, Jeffrey J, Goldstein, David S, Habecker, Beth A, Handoko, M Louis, Harvey, Robert, Hummel, James P, Hund, Thomas, Meyer, Christian, Redline, Susan, Ripplinger, Crystal M, Simon, Marc A, Somers, Virend K, Stavrakis, Stavros, Taylor-Clark, Thomas, Undem, Bradley Joel, Verrier, Richard L, Zucker, Irving H, Sopko, George, and Shivkumar, Kalyanam

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Neurosciences, Sleep Research, Heart Disease, Cardiovascular, Lung, &nbsp, asthma, atrial fibrillation, autonomic nervous system, cardiopulmonary, chronic obstructive pulmonary disease, circadian, heart failure, pulmonary arterial hypertension, sleep apnea, ventricular arrhythmia, ACE, angiotensin-converting enzyme, AD, autonomic dysregulation, AF, atrial fibrillation, ANS, autonomic nervous system, Ach, acetylcholine, CNS, central nervous system, COPD, chronic obstructive pulmonary disease, CSA, central sleep apnea, CVD, cardiovascular disease, ECG, electrocardiogram, EV, extracellular vesicle, GP, ganglionated plexi, HF, heart failure, HFpEF, heart failure with preserved ejection fraction, HFrEF, heart failure with reduced ejection fraction, HRV, heart rate variability, LQT, long QT, MI, myocardial infarction, NE, norepinephrine, NHLBI, National Heart, Lung, and Blood Institute, NPY, neuropeptide Y, NREM, non-rapid eye movement, OSA, obstructive sleep apnea, PAH, pulmonary arterial hypertension, PV, pulmonary vein, REM, rapid eye movement, RV, right ventricular, SCD, sudden cardiac death, SDB, sleep disordered breathing, SNA, sympathetic nerve activity, SNSA, sympathetic nervous system activity, TLD, targeted lung denervation, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular medicine and haematology
Abstract

This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.

Published
2022

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