46 results on '"Goldsmith, Shona"'
Search Results
2. Cerebral Palsy: Epidemiology
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Goldsmith, Shona, McIntyre, Sarah, Blair, Eve, Smithers-Sheedy, Hayley, Badawi, Nadia, Hansen, Michele, Eisenstat, David D., editor, Goldowitz, Dan, editor, Oberlander, Tim F., editor, and Yager, Jerome Y., editor
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- 2023
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3. Severe Congenital Heart Defects and Cerebral Palsy
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Garne, Ester, Goldsmith, Shona, Barisic, Ingeborg, Braz, Paula, Dakovic, Ivana, Gibson, Catherine, Hansen, Michele, Hoei-Hansen, Christina E., Hollung, Sandra Julsen, Klungsøyr, Kari, Smithers-Sheedy, Hayley, Virella, Daniel, Badawi, Nadia, Watson, Linda, and McIntyre, Sarah
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- 2023
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4. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus
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Shepherd, Emily S, additional, Goldsmith, Shona, additional, Doyle, Lex W, additional, Middleton, Philippa, additional, Marret, Stéphane, additional, Rouse, Dwight J, additional, Pryde, Peter, additional, Wolf, Hanne T, additional, and Crowther, Caroline A, additional
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- 2024
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5. Neonatal magnesium sulphate for neuroprotection: A systematic review and meta‐analysis.
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Shepherd, Emily, Karim, Tasneem, McIntyre, Sarah, Goldsmith, Shona, Keir, Amy, Badawi, Nadia, Hunt, Rod W., and Galinsky, Robert
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Aim: To review the evidence of the effects of neonatal magnesium sulphate for neuroprotection in perinatal asphyxia and hypoxic‐ischaemic encephalopathy (HIE). Method: This was a systematic review of randomized controlled trials (RCTs) (with meta‐analysis) and non‐RCTs assessing magnesium sulphate for treating perinatal asphyxia and HIE at 35 weeks or more gestation (primary outcomes: neonatal death and death or long‐term major neurodevelopmental disability). Results: Twenty‐five RCTs (2099 infants) and four non‐RCTs (871 infants) were included, 23 in low‐ and middle‐income countries (LMICs). In RCTs, reductions in neonatal death with magnesium sulphate versus placebo or no treatment (risk ratio [RR] = 0.68; 95% confidence interval [CI] = 0.53–0.86; 13 RCTs), and magnesium sulphate with melatonin versus melatonin alone (RR = 0.74; 95% CI = 0.58–0.95; one RCT) were observed. No difference in neonatal death was seen for magnesium sulphate with therapeutic hypothermia versus therapeutic hypothermia alone (RR = 0.66, 95% CI = 0.34–1.26; three RCTs), or magnesium sulphate versus phenobarbital (RR = 3.00; 95% CI = 0.86–10.46; one RCT). No reduction in death or long‐term neurodevelopmental disability (RR = 0.52; 95% CI = 0.14–1.89; one RCT) but reductions in several short‐term adverse outcomes were observed with magnesium sulphate. Evidence was low‐ to very‐low certainty because of risk of bias and imprecision. Interpretation: Given the uncertainty of the current evidence, further robust neonatal magnesium sulphate research is justified. This may include high‐quality studies to determine stand‐alone effects in LMICs and effects with and after therapeutic hypothermia in high‐income countries. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
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Shepherd, Emily S., Goldsmith, Shona, Doyle, Lex W., Middleton, Philippa, Marret, Stéphane, Rouse, Dwight J., Pryde, Peter, Wolf, Hanne T., and Crowther, Caroline A.
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PREGNANT women , *MAGNESIUM sulfate , *CHILDREN with cerebral palsy , *BRAIN death , *CEREBRAL palsy - Abstract
OBJECTIVE: To systematically review the evidence for the effectiveness and safety of magnesium sulfate as a fetal neuroprotective agent when given to individuals at risk of preterm birth. DATA SOURCES: We searched Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials.gov, the World Health Organization International Clinical Trials Registry Platform (through March 17, 2023), and reference lists of relevant studies. METHODS OF STUDY SELECTION: Randomized controlled trials (RCTs) assessing magnesium sulfate for fetal neuroprotection in pregnant participants at risk of imminent preterm birth were eligible. Two authors assessed RCTs for inclusion, extracted data, and evaluated risk of bias, trustworthiness, and evidence certainty (GRADE [Grading of Recommendations Assessment, Development and Evaluation]). TABULATION, INTEGRATION, AND RESULTS: We included six RCTs (5,917 pregnant participants and 6,759 fetuses at less than 34 weeks of gestation at randomization). They were conducted in high-income countries (two in the United States, two across Australia and New Zealand, and one each in Denmark and France) and commenced between 1995 and 2018. Primary outcomes: up to 2 years of corrected age, magnesium sulfate compared with placebo reduced the risk of cerebral palsy (risk ratio [RR] 0.71, 95% CI, 0.57-0.89; six RCTs, 6,107 children) and death or cerebral palsy (RR 0.87, 95% CI, 0.77-0.98; six RCTs, 6,481 children) (high-certainty evidence). Magnesium sulfate had little or no effect on death up to 2 years of corrected age (moderate-certainty evidence) or these outcomes at school age (low-certainty evidence). Although there was little or no effect on death or cardiac or respiratory arrest for pregnant individuals (low-certainty evidence), magnesium sulfate increased adverse effects severe enough to stop treatment (RR 3.21, 95% CI, 1.88-5.48; three RCTs, 4,736 participants; moderate-certainty evidence). Secondary outcome: magnesium sulfate reduced the risk of severe neonatal intraventricular hemorrhage (moderate-certainty evidence). CONCLUSION: Magnesium sulfate for preterm fetal neuroprotection reduces cerebral palsy and death or cerebral palsy for children. Further research is required on longer-term benefits and harms for children, effect variation by participant and treatment characteristics, and the generalizability of findings to low- and middleincome countries. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Epidemiology of Cerebral Palsy
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Himmelmann, Kate, McIntyre, Sarah, Goldsmith, Shona, Smithers-Sheedy, Hayley, Watson, Linda, Miller, Freeman, Section editor, Miller, Freeman, editor, Bachrach, Steven, editor, Lennon, Nancy, editor, and O'Neil, Margaret E., editor
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- 2020
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8. Cerebral palsy registers around the world: A survey.
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Goldsmith, Shona, Smithers‐Sheedy, Hayley, Almasri, Nihad, Andersen, Guro L., Diviney, Leanne, Gincota, Ecaterina Bufteac, Himmelmann, Kate, Jahan, Israt, Waight, Emma, and McIntyre, Sarah
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CEREBRAL palsy , *NONPROFIT organizations , *MIDDLE-income countries , *DESCRIPTIVE statistics , *INTERNET surveys - Abstract
Aim: To provide a description of cerebral palsy (CP) registers globally, identify which aim to report on CP epidemiology, and report similarities and differences across topics of importance for the sustainability and collaboration between registers. Method: Representatives of all known CP registers globally (n = 57) were invited to participate. The online survey included 68 questions across aims, methodologies, output/impact, and stakeholder involvement. Responses were analysed using descriptive statistics. Results: Forty‐five registers participated, including three register networks. Twenty were newly established or under development, including 12 in low‐ and middle‐income countries (LMICs). An epidemiological aim was reported by 91% of registers. Funding is received by 85% of registers, most often from not‐for‐profit organizations. CP definitions are comparable across registers. While the minimum data set of a register network is used by most registers, only 25% of identified items are collected by all three register networks. Ninety per cent of registers measure research activities/output, and 64% measure research impact. People with lived experience are involved in 62% of registers. Interpretation: There has been a recent surge in CP registers globally, particularly in LMICs, which will improve understanding of CP epidemiology. Ongoing efforts to address identified methodological differences are essential to validate comparison of results and support register collaboration. What this paper adds: Cerebral palsy (CP) registers represent an increasing number of regions, including low‐ and middle‐income, worldwide.Most registers collect the minimum data set of a CP register network.Research activities/output and impact are measured by most registers.The majority of registers involve people with lived experience in operation or research. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Cerebral palsy registers around the world: A survey
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Goldsmith, Shona, primary, Smithers‐Sheedy, Hayley, additional, Almasri, Nihad, additional, Andersen, Guro L., additional, Diviney, Leanne, additional, Gincota, Ecaterina Bufteac, additional, Himmelmann, Kate, additional, Jahan, Israt, additional, Waight, Emma, additional, and McIntyre, Sarah, additional
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- 2023
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10. A comparison of cohorts of children with cerebral palsy from a population register and hospital admission data: A data linkage study.
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Paget, Simon P., McIntyre, Sarah, Lain, Samantha, Goldsmith, Shona, and Nassar, Natasha
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CHILDREN with cerebral palsy ,HOSPITAL admission & discharge ,YOUNG adults ,CHILDREN with intellectual disabilities ,PEOPLE with cerebral palsy ,FRAIL elderly ,METROPOLIS ,AGENESIS of corpus callosum - Abstract
Background: Administrative health data, such as hospital admission data, are often used in research to identify children/young people with cerebral palsy (CP). Objectives: To compare sociodemographic, clinical details and mortality of children/young people identified as having CP in either a CP population registry or hospital admission data. Methods: We identified two cohorts of children/young people (birth years 2001–2010, age at study end or death 2 months to 19 years 6 months) with a diagnosis of CP from either (i) the New South Wales (NSW)/Australian Capital Territory (ACT) CP Register or (ii) NSW hospital admission data (2001–2020). Using record linkage, these data sources were linked to each other and NSW Death, Perinatal, and Disability datasets. We determined the sensitivity and positive predictive value (PPV) of CP diagnosis in hospital admission data compared with the NSW/ACT CP Register (gold standard). We then compared the sociodemographic and clinical characteristics and mortality of the two cohorts available through record linkage using standardised mean difference (SMD). Results: There were 1598 children/young people with CP in the NSW/ACT CP Register and 732–2439 children/young people with CP in hospital admission data, depending on the case definition used. The sensitivity of hospital admission data for diagnosis of CP ranged from 0.40–0.74 and PPV 0.47–0.73. Compared with children/young people with CP identified in the NSW/ACT CP Register, a greater proportion of those identified in hospital admission data (one or more admissions with G80 case definition) were older, lived in major cities, had comorbidities including epilepsy, gastrostomy use, intellectual disability and autism, and died during the study period (SMD > 0.1). Conclusions: Sociodemographic and clinical characteristics differ between cohorts of children/young people with CP identified using a CP register or hospital admission data. Those identified in hospital admission data have higher rates of comorbidities and death, suggesting some may have progressive conditions and not CP. These differences should be considered when planning and interpreting research using various data sources. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Epidemiology of Cerebral Palsy
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Himmelmann, Kate, primary, McIntyre, Sarah, additional, Goldsmith, Shona, additional, Smithers-Sheedy, Hayley, additional, and Watson, Linda, additional
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- 2018
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12. Determinants of Hospital-Based Health Service Utilization in Cerebral Palsy: a Systematic Review
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Paget, Simon, primary, Ostojic, Katarina, additional, Goldsmith, Shona, additional, Nassar, Natasha, additional, and McIntyre, Sarah, additional
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- 2022
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13. Cerebral palsy after assisted reproductive technology: a cohort study
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Goldsmith, Shona, Mcintyre, Sarah, Badawi, Nadia, and Hansen, Michele
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- 2018
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14. Global prevalence of cerebral palsy: A systematic analysis
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McIntyre, Sarah, Goldsmith, Shona, Webb, Annabel, Ehlinger, Virginie, Julsen Hollung, Sandra, McConnell, Karen, Arnaud, Catherine, Smithers-Sheedy, Hayley, Oskoui, Maryam, Khandaker, Gulam, Himmelmann, Kate, and Kerr, Claire
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Cerebral Palsy ,Infant, Newborn ,Australia ,SDG 8 - Decent Work and Economic Growth ,Europe ,Developmental Neuroscience ,Pregnancy ,Pediatrics, Perinatology and Child Health ,Prevalence ,Humans ,Female ,Neurology (clinical) ,Poverty - Abstract
AimTo determine trends and current estimates in regional and global prevalence of cerebral palsy (CP).MethodA systematic analysis of data from participating CP registers/surveillance systems and population-based prevalence studies (from birth year 1995) was performed. Quality and risk of bias were assessed for both data sources. Analyses were conducted for pre-/perinatal, postnatal, neonatal, and overall CP. For each region, trends were statistically classified as increasing, decreasing, heterogeneous, or no change, and most recent prevalence estimates with 95% confidence intervals (CI) were calculated. Meta-analyses were conducted to determine current birth prevalence estimates (from birth year 2010).ResultsForty-one regions from 27 countries across five continents were represented. Pre-/perinatal birth prevalence declined significantly across Europe and Australia (11 out of 14 regions), with no change in postneonatal CP. From the limited but increasing data available from regions in low- and middle-income countries (LMICs), birth prevalence for pre-/perinatal CP was as high as 3.4 per 1000 (95% CI 3.0–3.9) live births. Following meta-analyses, birth prevalence for pre-/perinatal CP in regions from high-income countries (HICs) was 1.5 per 1000 (95% CI 1.4–1.6) live births, and 1.6 per 1000 (95% CI 1.5–1.7) live births when postneonatal CP was included.InterpretationThe birth prevalence estimate of CP in HICs declined to 1.6 per 1000 live births. Data available from LMICs indicated markedly higher birth prevalence.What this paper adds• Birth prevalence of pre-/perinatal cerebral palsy (CP) in high-income countries (HICs) is decreasing.• Current overall CP birth prevalence for HICs is 1.6 per 1000 live births.• Trends in low- and middle-income countries (LMICs) cannot currently be measured.• Current birth prevalence in LMICs is markedly higher than in HICs.• Active surveillance of CP helps to assess the impact of medical advancements and social/economic development.• Population-based data on prevalence and trends of CP are critical to inform policy.
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- 2022
15. Epidemiology of Cerebral Palsy among Children and Adolescents in Arabic-Speaking Countries: A Systematic Review and Meta-Analysis
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Mushta, Sami Mukhdari, primary, King, Catherine, additional, Goldsmith, Shona, additional, Smithers-Sheedy, Hayley, additional, Badahdah, Al-Mamoon, additional, Rashid, Harunor, additional, Badawi, Nadia, additional, Khandaker, Gulam, additional, and McIntyre, Sarah, additional
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- 2022
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16. Non‐attendance at outpatient clinic appointments by children with cerebral palsy
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Paget, Simon P., primary, McIntyre, Sarah, additional, Goldsmith, Shona, additional, Ostojic, Katarina, additional, Shrapnel, Jane, additional, Schneuer, Francisco, additional, Waugh, Mary‐Clare, additional, Kyriagis, Maria, additional, and Nassar, Natasha, additional
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- 2022
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17. Congenital anomalies in cerebral palsy: where to from here?
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McIntyre, Sarah, Blair, Eve, Goldsmith, Shona, Badawi, Nadia, Gibson, Catherine, Scott, Heather, and Smithers-Sheedy, Hayley
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- 2016
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18. Temporal trends in cerebral palsy by impairment severity and birth gestation
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Reid, Susan M, Meehan, Elaine, McIntyre, Sarah, Goldsmith, Shona, Badawi, Nadia, and Reddihough, Dinah S
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- 2016
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19. An international survey of cerebral palsy registers and surveillance systems
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Goldsmith, Shona, McIntyre, Sarah, Smithers-Sheedy, Hayley, Blair, Eve, Cans, Christine, Watson, Linda, and Yeargin-Allsopp, Marshalyn
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- 2016
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20. Australia and the Australian Cerebral Palsy Register for the birth cohort 1993 to 2006
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Badawi, Nadia, Balde, Isabelle, Goldsmith, Shona, Karlsson, Petra, McIntyre, Sarah, Novak, Iona, Smithers-Sheedy, Hayley, Edwards, Keith, OʼKearney, Emily, Tessman, Kate, deLacy, Michael, Louca, Christalla, Gibson, Catherine, Rice, Rosie, Scott, Heather, Bartlett-Clark, Kirsty, Maloney, Eliza, Rowell, Madeline, Sheppard, Robyn, Quamby, Lyndsay, Meehan, Elaine, Reddihough, Dinah, Reid, Sue, Blair, Eve, Gibson, Noula, Love, Sarah, and Watson, Linda
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- 2016
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21. A special supplement: findings from the Australian Cerebral Palsy Register, birth years 1993 to 2006
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Smithers-Sheedy, Hayley, McIntyre, Sarah, Gibson, Catherine, Meehan, Elaine, Scott, Heather, Goldsmith, Shona, Watson, Linda, Badawi, Nadia, Walker, Karen, Novak, Iona, and Blair, Eve
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- 2016
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22. Cerebral palsy in twins and higher multiple births: a Europe‐Australia population‐based study
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Sellier, Ellodie, Goldsmith, Shona, McIntyre, Sarah, Perra, Oliver, Rackauskaite, Gija, Badawi, Nadia, Fares, Asma, Smithers-Sheedy, Hayley, Collaborators: Ego, A, Tronc, C, Arnaud, C, Delobel, M, Mc Manus, V, Lyons, A, Perra, O, McConnel, K, Himmelmann, K, Pahlman, M, Hensey, O, Dowding, V, Kurinczuk, J, Rackauskaite, G, Laursen, B, Torrioli, MG, Marcelli, M, Andersen, GL, Julsen Hollung, S, Bottos, M, Gaffney, G, de la Cruz, J, Pallas, C, Neubauer, D, Radsel, A, Virella, D, Folha, T, Greitane, A, Hollody, Csabi, G, Đaković, Ivana, Sigurðardóttir, S, Einarsson, I, Haberlandt, E, Ortibus, E, Franki, I, Mejaški- Bošnjak, Vlatka, Kuenzle, C, Tscherter, A, Attard, S, Papavasilou, A, Horridge, K, Platt, MJ, Krägeloh-Mann, I, Horber, V, Auld, M, Badawi, N, Blair, E, Diviney, L, Gibson, C, Gibson, N, Goldsmith, S, Gration, D, Hernandez, J, Langdon, K, Love, S, Maloney, E, Martin, T, McIntyre, S, Kay, F, O'Grady, G, Reddihough, D, Reid, S, Scott, H, Smithers-Sheedy, H, and Watson, L
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Male ,Risk ,030506 rehabilitation ,medicine.medical_specialty ,Population ,Clinical Neurology ,Gestational Age ,Multiple Birth Offspring ,Cerebral palsy ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,Developmental Neuroscience ,Pregnancy ,medicine ,Prevalence ,Birth Weight ,Humans ,Registries ,Pediatrics, Perinatology, and Child Health ,cerebral palsy ,twins ,education ,Denominator data ,education.field_of_study ,Obstetrics ,business.industry ,Cerebral Palsy ,Australia ,Gestational age ,Gross Motor Function Classification System ,medicine.disease ,Confidence interval ,Europe ,Quadruplets ,Cross-Sectional Studies ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Premature Birth ,Female ,Neurology (clinical) ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Aim:To describe the birth prevalence, temporal trends, and clinical outcomes of twins, triplets, or quadruplets with cerebral palsy (CP).Method:This was a cross-sectional study using data for twins, triplets, and quadruplets with prenatally or perinatally acquired CP and pooled from the Surveillance of Cerebral Palsy in Europe network (born 1992–2009) and Australian Cerebral Palsy Register (born 1993–2009). Children were at least 4 years old at time of registration. Children born in regions with population ascertainment and available denominator data were included in prevalence calculations (n=1033 twins, 81 triplets, and 11 quadruplets). Clinical data from children registered in all participating registers were described, including 2163 twins (56% male), 187 triplets (59% male), and 20 quadruplets (45% male).Results:The birth prevalence of CP was higher with increasing plurality (twins 6.5 per 1000 live births [95% confidence interval {CI} 6.1–6.9], triplets 17.1 [95% CI 13.6–21.2], quadruplets 50.7 [95% CI 25.6–88.9]); however, prevalence by gestational age was similar across all pluralities. Between 1992–1994 and 2007–2009, prevalence of CP among twins declined (p=0.001) but prevalence of CP among triplets did not change significantly over time (p=0.55). The distributions of Gross Motor Function Classification System, epilepsy, and impairments of intellect, vision, and hearing were similar regardless of plurality.Interpretation:The data combined from two CP register networks indicated that triplets and quadruplets had increased risk of CP compared to twins. The higher prevalence of CP in triplets and quadruplets is due to their higher risk of preterm birth. Prevalence of CP among twins significantly declined in Europe and Australia. Clinical outcomes were similar for all multiple births.
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- 2021
23. The accuracy of hospital discharge data in recording major congenital anomalies in Australia
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Schneuer, Francisco J., primary, Lain, Samantha J., additional, Bell, Jane C., additional, Goldsmith, Shona, additional, McIntyre, Sarah, additional, and Nassar, Natasha, additional
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- 2021
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24. Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
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Goldsmith, Shona, McIntyre, Sarah, Scott, Heather, Himmelmann, Kate, Smithers‐Sheedy, Hayley, Andersen, Guro L, Blair, Eve, Badawi, Nadia, Garne, Ester, Barisic, Ingeborg, Bosnjak Mejaski, Vlatka, Amar, Emmanuelle, Sellier, Elodie, Hollung, Sandra Julsen, Klungsøyr, Kari, Braz, Paula, Virella, Daniel, Gibson, Catherine, Källén, Karin, Reid, Susan M, Baynam, Gareth, Gration, Dylan, Hansen, Michèle, Watson, Linda, and The Comprehensive CA‐CP Study Group
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Male ,Registo Nacional de Anomalias Congénitas ,Information Storage and Retrieval ,Congenital Abnormalities ,European Surveillance of Congenital Anomalies ,Developmental Neuroscience ,Data Linkage ,EUROCAT ,Prevalence ,Humans ,Registries ,Child ,Portugal ,Cerebral Palsy ,congenital anomalies ,cerebral palsy ,registries ,RENAC ,Australia ,Congenital Anomalies ,Estados de Saúde e de Doença ,Observação em Saúde e Vigilância ,PVNPC ,Europe ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,Neurology (clinical) - Abstract
Comprehensive CA-CP Study Group: Ingeborg Barisic, Vlatka Bosnjak Mejaski, Emmanuelle Amar, Elodie Sellier, Sandra Julsen Hollung, Kari Klungsøyr, Paula Braz, Daniel Virella, Catherine Gibson, Karin Källén, Susan M Reid, Gareth Baynam, Dylan Gration, Michèle Hansen, Linda Watson Comprehensive CA-CP Study Group: Paula Braz, Daniel Virella. INSA, Portugal. Aim: To describe the major congenital anomalies present in children with postneonatally acquired cerebral palsy (CP), and to compare clinical outcomes and cause of postneonatally acquired CP between children with and without anomalies. Method: Data were linked between total population CP and congenital anomaly registers in five European and three Australian regions for children born 1991 to 2009 (n=468 children with postneonatally acquired CP; 255 males, 213 females). Data were pooled and children classified into mutually exclusive categories based on type of congenital anomaly. The proportion of children with congenital anomalies was calculated. Clinical outcomes and cause of postneonatally acquired CP were compared between children with and without anomalies. Results: Major congenital anomalies were reported in 25.6% (95% confidence interval [CI] 21.7-29.9) of children with postneonatally acquired CP. Cardiac anomalies, often severe, were common and present in 14.5% of children with postneonatally acquired CP. Clinical outcomes were not more severe in children with congenital anomalies than those without anomalies. Cause of postneonatally acquired CP differed with the presence of congenital anomalies, with cerebrovascular accidents predominating in the anomaly group. Congenital anomalies were likely associated with cause of postneonatally acquired CP in 77% of children with anomalies. Interpretation: In this large, international study of children with postneonatally acquired CP, congenital anomalies (particularly cardiac anomalies) were common. Future research should determine specific causal pathways to postneonatally acquired CP that include congenital anomalies to identify opportunities for prevention. What this paper adds: One-quarter of children with postneonatally acquired cerebral palsy (CP) have a major congenital anomaly. Cardiac anomalies, often severe, are the most common anomalies. Causes of postneonatally acquired CP differ between children with and without congenital anomalies. Objetivo: Describir las principales anomalías congenitas presentes en niños con parálisis cerebral (PC) adquirida posnatalmente y comparar los resultados clínicos y la causa de PC entre niños con y sin anomalías. Método: Se relacionaron los registros de datos de la población con PC y los registros de anomalías congenitas de cinco regiones de Europa y tres de Australia de niños nacidos de 1991 a 2009 (n = 468 niños con PC adquirida posnatalmente; 255 varones, 213 mujeres). Se agruparon los datos y clasificaron en categor ıas mutuamente excluyentes segun el tipo de anomalías congenita. Se calcul o la pro-porcion de ni nos con anomalías congenitas. Se compararon los resultados clínicos y la causa de la PC adquirida posnatalmente entre niños con y sin anomalías. Resultados: Se registraron anomalías congenitas importantes en el 25,6% (intervalo de confianza [IC] del 95%: 21,7-29,9) de los niños con PC adquirida despues del nacimiento. Hubo una alta frecuencia de anomalías cardíacas, que estaban presentes en el 14,5% de los niños con PC adquirida posnatalmente. La evolución clínica no fue diferentes entre niños con o sin anomalías congenitas. La causa de PC adquirida posnatalmente vario con la presencia de anomalías congenitas, predominando los accidentes cerebrovasculares en el grupo de anomalías congenitas. La causa de PC adquirida posnatalmente esta probablemente asociada con anomalias congenitas en el 77% de los niños con anomalías. Interpretacion: En este estudio internacional de niños con PC adquirida posnatalmente, las anomalías congenitas fueron frecuentes, particularmente las anomalías cardíacas. Las investigaciones futuras deben determinar las vías causales específicas de la PC adquirida posnatalmente que incluyen anomalías congenitas para identificar oportunidades de prevención. info:eu-repo/semantics/publishedVersion
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- 2021
25. Declining trends in birth prevalence and severity of singletons with cerebral palsy of prenatal or perinatal origin in Australia: A population‐based observational study.
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Smithers‐Sheedy, Hayley, Waight, Emma, Goldsmith, Shona, Reid, Sue, Gibson, Catherine, Watson, Linda, Auld, Megan, Badawi, Nadia, Webb, Annabel, Diviney, Leanne, Mcintyre, Sarah, Ostojic, Katarina, Kay, Fiona, Quartermaine, Jacinta, Maloney, Eliza, Davies, Nadine, and Hinwood, Gina
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Aim: To investigate temporal trends in birth prevalence, disability severity, and motor type for singletons with prenatal or perinatally acquired cerebral palsy (CP). Method: Numerator data, number of children with CP born a singleton between 1995 and 2014, confirmed at 5 years of age, were drawn from three state registers with population‐level ascertainment. Birth prevalence estimates and 95% confidence intervals (CI) were calculated per 1000 singleton live births for the three states combined, overall, by gestational age group, by dichotomized disability severity, and spastic laterality. Poisson regression models were used to analyse trends. Using data from all eight registers, trends in the proportional distribution of CP subtypes overall and stratified by gestational age were examined. Results: Birth prevalence of CP declined from 1.8 (95% CI 1.6–2.0) in 1995 to 1996 to 1.2 (95% CI 1.1–1.4) in 2013 to 2014 (average 5% per 2‐year epoch, p < 0.001). Declines in birth prevalence were observed across all gestational age groups with the largest decline in children born at <28 weeks (average 8% per epoch, p < 0.001). Prevalence of moderate‐severe disability declined for children born at <28 and ≥37 weeks (average 11% and 7% per epoch respectively, p < 0.001). The proportions of bilateral spastic CP declined (p < 0.001) at <28 weeks (p = 0.014) and ≥37 weeks (p < 0.001). The proportion of children with dyskinesia increased (28–31 weeks: p = 0.021, 32–36 weeks: p = 0.001, and ≥37 weeks: p < 0.001). Interpretation: Birth prevalence of CP and moderate‐severe disability (<28 and ≥37 weeks) declined in Australian singletons between 1995 and 2014, reflecting changes in prenatal and perinatal care over time. What this paper adds: Declines in birth prevalence of prenatal or perinatally acquired cerebral palsy were observed for singletons born in Australia between 1995 and 2014.These declines were evident across all gestational age groups.Declines in birth prevalence of moderate‐severe disability were observed for children born at <28 weeks and ≥37 weeks. What this paper adds: Declines in birth prevalence of prenatal or perinatally acquired cerebral palsy were observed for singletons born in Australia between 1995 and 2014.These declines were evident across all gestational age groups.Declines in birth prevalence of moderate‐severe disability were observed for children born at <28 weeks and ≥37 weeks. This original article is commented on by Villamor on pages 1054–1055 of this issue. [ABSTRACT FROM AUTHOR]
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- 2022
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26. Researching conductive education
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NOVAK, IONA, MCINTYRE, SARAH, MORGAN, CATHERINE, CAMPBELL, LANIE, DARK, LEIGHA, MORTON, NATALIE, STUMBLES, ELISE, WILSON, SALLI-ANN, and GOLDSMITH, SHONA
- Published
- 2014
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27. A systematic review of interventions for children with cerebral palsy: state of the evidence
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novak, Iona, Mcintyre, Sarah, Morgan, Catherine, Campbell, Lanie, Dark, Leigha, Morton, Natalie, Stumbles, Elise, Wilson, Salli-Ann, and Goldsmith, Shona
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- 2013
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28. EFFECTIVE INTERVENTIONS FOR CHILDREN WITH CEREBRAL PALSY: A SYSTEMATIC REVIEW OF SYSTEMATIC REVIEWS: O40
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Novak, Iona, McIntyre, Sarah, Morgan, Cathy, Campbell, Lanie, Dark, Leigha, Morton, Natalie, Stumbles, Elise, Craik, Salli Ann, and Goldsmith, Shona
- Published
- 2013
29. A systematic review of risk factors for cerebral palsy in children born at term in developed countries
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Mcintyre, Sarah, Taitz, David, Keogh, John, Goldsmith, Shona, Badawi, Nadia, and Blair, Eve
- Published
- 2013
- Full Text
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30. Protocol for the Sri Lankan Cerebral Palsy Register pilot study
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Heiyanthuduwage, Thilini Madushika, primary, Sumanasena, Samanmali P, additional, Kitnasamy, Gopi, additional, Smithers Sheedy, Hayley, additional, Khandaker, Gulam, additional, Fernando, Romaniya, additional, Wijesekara, Saraji, additional, Jagoda, Jayatri, additional, Ratnayake, Pyara, additional, Wanigasinghe, Jithangi, additional, Mclntyre, Sarah, additional, Goldsmith, Shona, additional, Waight, Emma, additional, Badawi, Nadia, additional, Muhit, Mohammad, additional, and Muttiah, Nimisha, additional
- Published
- 2020
- Full Text
- View/download PDF
31. Supplemental Material, Goldsmith_Supplementary_Material_References_updated - Congenital Anomalies in Children With Cerebral Palsy: A Systematic Review
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Goldsmith, Shona, McIntyre, Sarah, Hansen, Michele, and Badawi, Nadia
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FOS: Clinical medicine ,111403 Paediatrics ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental Material, Goldsmith_Supplementary_Material_References_updated for Congenital Anomalies in Children With Cerebral Palsy: A Systematic Review by Shona Goldsmith, Sarah McIntyre, Michele Hansen and Nadia Badawi in Journal of Child Neurology
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- 2019
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32. Population studies of assisted reproductive technology and congenital anomalies in cerebral palsy
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Goldsmith, Shona
- Subjects
assisted reproductive technology ,congenital anomaly ,birth defect ,epidemiology - Abstract
BACKGROUND: Risk factors for cerebral palsy (CP) have been identified across the conception, pregnancy, perinatal and postneonatal periods, including Assisted Reproductive Technology (ART) and congenital anomalies. ART likely increases risk of CP through mediating factors including multiple and preterm birth, but this requires further investigation in Australia. While congenital anomalies are an identified risk factor for CP, their reported prevalence varies widely. This thesis describes the epidemiology of CP with respect to these two independent factors. METHODS: A series of population-based studies were conducted. The influence of ART on prevalence of CP and clinical outcomes in Western Australia was explored in a population-based data-linkage study. Population-based research describing congenital anomalies in CP was synthesised in a systematic literature review. The most common congenital anomaly in CP from the review, congenital microcephaly, was investigated in a Western Australian population case-control study. Finally, population data-linkages were conducted in Australia and Europe to examine major congenital anomalies and outcomes in children with pre/perinatally acquired CP and postneonatally acquired CP (PNN-CP). RESULTS: ART was associated with a two-fold increased risk of CP. While multiple and preterm births were common after ART, additional risk of CP existed for very preterm ART singletons. The systematic review identified congenital anomalies in 12–32% of children with pre/perinatal CP and 20% of PNN-CP. Children with CP had a three-fold risk of congenital microcephaly in the case-control study. In Australia and Europe, congenital anomalies were identified in approximately one in four children with CP. Isolated cerebral anomalies were most common in children with pre/perinatally acquired CP, and isolated cardiac anomalies in PNN-CP. Congenital anomalies were associated with more severe outcomes for children with pre/perinatally acquired CP, but not PNN-CP. CONCLUSION: ART and congenital anomalies are important factors in the epidemiology of CP, and opportunities for prevention may lie in these pathways to CP. Research is planned to: a) evaluate temporal trends in ART and CP in Australia and b) further elucidate pathways and risk of CP for children with specific anomalies.
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- 2019
33. Cerebral palsy in twins and higher multiple births: a Europe‐Australia population‐based study.
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Sellier, Elodie, Goldsmith, Shona, McIntyre, Sarah, Perra, Oliver, Rackauskaite, Gija, Badawi, Nadia, Fares, Asma, Smithers‐Sheedy, Hayley, Ego, A, Tronc, C, Arnaud, C, Delobel, M, Mc Manus, V, Lyons, A, Perra, O, McConnel, K, Himmelmann, K, Pahlman, M, Hensey, O, and Dowding, V
- Subjects
- *
MULTIPLE birth , *CEREBRAL palsy , *TWINS , *QUADRUPLETS , *TRIPLETS - Abstract
Aim: To describe the birth prevalence, temporal trends, and clinical outcomes of twins, triplets, or quadruplets with cerebral palsy (CP). Method: This was a cross‐sectional study using data for twins, triplets, and quadruplets with prenatally or perinatally acquired CP and pooled from the Surveillance of Cerebral Palsy in Europe network (born 1992–2009) and Australian Cerebral Palsy Register (born 1993–2009). Children were at least 4 years old at time of registration. Children born in regions with population ascertainment and available denominator data were included in prevalence calculations (n=1033 twins, 81 triplets, and 11 quadruplets). Clinical data from children registered in all participating registers were described, including 2163 twins (56% male), 187 triplets (59% male), and 20 quadruplets (45% male). Results: The birth prevalence of CP was higher with increasing plurality (twins 6.5 per 1000 live births [95% confidence interval {CI} 6.1–6.9], triplets 17.1 [95% CI 13.6–21.2], quadruplets 50.7 [95% CI 25.6–88.9]); however, prevalence by gestational age was similar across all pluralities. Between 1992–1994 and 2007–2009, prevalence of CP among twins declined (p=0.001) but prevalence of CP among triplets did not change significantly over time (p=0.55). The distributions of Gross Motor Function Classification System, epilepsy, and impairments of intellect, vision, and hearing were similar regardless of plurality. Interpretation: The data combined from two CP register networks indicated that triplets and quadruplets had increased risk of CP compared to twins. The higher prevalence of CP in triplets and quadruplets is due to their higher risk of preterm birth. Prevalence of CP among twins significantly declined in Europe and Australia. Clinical outcomes were similar for all multiple births. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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34. Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study.
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Goldsmith, Shona, Mcintyre, Sarah, Andersen, Guro L, Gibson, Catherine, Himmelmann, Kate, Blair, Eve, Badawi, Nadia, Smithers‐Sheedy, Hayley, and Garne, Ester
- Subjects
- *
CONGENITAL disorders , *CEREBRAL palsy , *BRAIN abnormalities , *CHILD patients - Abstract
Aim: To describe the frequency and types of major congenital anomalies present in children with pre‐ or perinatally acquired cerebral palsy (CP), and compare clinical outcomes for children with and without anomalies. Method: This multi‐centre total population collaborative study between Surveillance of Cerebral Palsy in Europe, Australian Cerebral Palsy Register, and European Surveillance of Congenital Anomalies (EUROCAT) involved six European and three Australian regions. Data were linked between each region's CP and congenital anomaly register for children born between 1991 and 2009, and then pooled. Children were classified into mutually exclusive categories based on type of anomaly. Proportions of children with congenital anomalies were calculated, and clinical outcomes compared between children with and without anomalies. Results: Of 8201 children with CP, 22.8% (95% confidence interval [CI] 21.9, 23.8) had a major congenital anomaly. Isolated cerebral anomalies were most common (45.2%), with a further 8.6% having both cerebral and non‐cerebral anomalies. Cardiac anomalies only were described in 10.5% of children and anomalies associated with syndromes were also reported: genetic (8.0%), chromosomal (5.7%), and teratogenic (3.0%). Clinical outcomes were more severe for children with CP and congenital anomalies, particularly cerebral anomalies. Interpretation: This large, international study reports major congenital anomalies in nearly one‐quarter of children with pre‐ or perinatally acquired CP. Future research must focus on aetiological pathways to CP that include specific patterns of congenital anomalies. What this paper adds: Congenital anomalies were reported in 23% of children with pre‐ or perinatally acquired cerebral palsy.A higher proportion of children born at or near term had anomalies.The most common type of anomalies were isolated cerebral anomalies.Clinical outcomes were more severe for children with congenital anomalies (particularly cerebral). What this paper adds: Congenital anomalies were reported in 23% of children with pre‐ or perinatally acquired cerebral palsy.A higher proportion of children born at or near term had anomalies.The most common type of anomalies were isolated cerebral anomalies.Clinical outcomes were more severe for children with congenital anomalies (particularly cerebral). This article is commented on by Kirby on pages 366–367 of this issue. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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35. Congenital Anomalies in Children With Cerebral Palsy: A Systematic Review
- Author
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Goldsmith, Shona, primary, McIntyre, Sarah, additional, Hansen, Michele, additional, and Badawi, Nadia, additional
- Published
- 2019
- Full Text
- View/download PDF
36. Adults with cerebral palsy: findings from a population‐based register
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Goldsmith, Shona, primary
- Published
- 2019
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37. Protocol for the Sri Lankan Cerebral Palsy Register pilot study.
- Author
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Thilini Madushika Heiyanthuduwage, Sumanasena, Samanmali P., Kitnasamy, Gopi, Sheedy, Hayley Smithers, Khandaker, Gulam, Fernando, Romaniya, Wijesekara, Saraji, Jagoda, Jayatri, Ratnayake, Pyara, Wanigasinghe, Jithangi, Mclntyre, Sarah, Goldsmith, Shona, Waight, Emma, Badawi, Nadia, Muhit, Mohammad, and Muttiah, Nimisha
- Abstract
Introduction: Cerebral palsy (CP) describes a heterogeneous group of motor disorders resulting from disturbance in the developing brain. CP occurs in approximately 2.1 per 1000 live births in high-income countries, but in low- and middle-income countries (LMICs) the prevalence and severity of CP may be greater and aetiological risk factors different. In Sri Lanka, a LMIC, there have been no epidemiological studies of CP to date. Systematically collected data are required to identify opportunities for primary and secondary prevention, to plan and establish services to support children and adults with CP and their families and to act as a sampling frame for new research. Here we describe a pilot study protocol for a CP register in Sri Lanka. Methods and analysis: The aim of this study is to establish a CP register in Sri Lanka. We will use different surveillance methodologies in two provinces of Sri Lanka: hospital and community surveillance in the Western Province and community surveillance in the Eastern Province. A common record form will collect demographic, clinical and service data for children with CP <18 years living in these two provinces. Data will be transferred to a secure online data repository and used to describe the epidemiology of CP in these regions. We will describe the strengths and challenges of the surveillance mechanisms and estimate the resources required for ongoing hospital and community based surveillance in the Western and Eastern provinces and to include additional provinces across the country. Ethics and dissemination: This study has ethical clearance from The University of Kelaniya, National Health Research Council, the Institutional Ethics Review Committee of the Lady Ridgeway Hospital, Colombo South Teaching Hospital and the Director of the North Colombo Teaching Hospital. Results from this research will be disseminated through local and international conferences and through publications in peer-reviewed journals. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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- View/download PDF
38. Comprehensive investigation of congenital anomalies in cerebral palsy: protocol for a European-Australian population-based data linkage study (The Comprehensive CA-CP Study)
- Author
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Goldsmith, Shona, primary, Garcia Jalon, Guiomar, additional, Badawi, Nadia, additional, Blair, Eve, additional, Garne, Ester, additional, Gibson, Catherine, additional, McIntyre, Sarah, additional, Scott, Heather, additional, Smithers-Sheedy, Hayley, additional, and Andersen, Guro L, additional
- Published
- 2018
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39. Cerebral palsy after assisted reproductive technology: a cohort study
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Goldsmith, Shona, primary, Mcintyre, Sarah, additional, Badawi, Nadia, additional, and Hansen, Michele, additional
- Published
- 2017
- Full Text
- View/download PDF
40. Australian Cerebral Palsy Register Report 2016
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Group, The Australian Cerebral Palsy Register, Badawi, Nadia, Balde, Isabelle, Goldsmith, Shona, Karlsson, Petra, McIntyre, Sarah, Novak, Iona, Novak, Paul, Smithers-Sheedy, Hayley, Edwards, Keith, Jarman, Rebecca, DeLacy, Michael, Christalla Louca, Gibson, Catherine, Rice, Rosie, Scott, Heather, Maloney, Eliza, Rowell, Madeline, Sheppard, Robyn, Quamby, Lyndsay, Meehan, Elaine, Reddihough, Dinah, Reid, Sue, Blair, Eve, Noula Gibson, Love, Sarah, Watson, Linda, and Bartlett-Clark, Kirsty
- Published
- 2016
- Full Text
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41. Cerebral palsy trends in Australia (1995-2009): a population-based observational study.
- Author
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Galea, Claire, Mcintyre, Sarah, Smithers-Sheedy, Hayley, Reid, Susan M, Gibson, Catherine, Delacy, Michael, Watson, Linda, Goldsmith, Shona, Badawi, Nadia, Blair, Eve, and Australian Cerebral Palsy Register Group
- Subjects
CHILDREN with cerebral palsy ,DISEASE prevalence ,NEONATAL diseases ,GESTATIONAL age ,PUBLIC health ,CHILDREN with disabilities ,AGE distribution ,CEREBRAL palsy ,COMPARATIVE studies ,DEVELOPMENTAL disabilities ,HEALTH planning ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,DISEASE complications - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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42. Novak et al. reply
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Novak, Iona, primary, McIntyre, Sarah, additional, Morgan, Catherine, additional, Campbell, Lanie, additional, Dark, Leigha, additional, Morton, Natalie, additional, Stumbles, Elise, additional, Wilson, Salli-Ann, additional, and Goldsmith, Shona, additional
- Published
- 2014
- Full Text
- View/download PDF
43. A systematic review of risk factors for cerebral palsy in children born at term in developed countries
- Author
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MCINTYRE, SARAH, primary, TAITZ, DAVID, additional, KEOGH, JOHN, additional, GOLDSMITH, SHONA, additional, BADAWI, NADIA, additional, and BLAIR, EVE, additional
- Published
- 2012
- Full Text
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44. Clinical Prognostic Messages From a Systematic Review on Cerebral Palsy
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Novak, Iona, primary, Hines, Monique, additional, Goldsmith, Shona, additional, and Barclay, Richard, additional
- Published
- 2012
- Full Text
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45. ‘Just like you’: A disability awareness programme for children that enhanced knowledge, attitudes and acceptance: Pilot study findings
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Ison, Nicole, primary, McIntyre, Sarah, additional, Rothery, Sophie, additional, Smithers-Sheedy, Hayley, additional, Goldsmith, Shona, additional, Parsonage, Samantha, additional, and Foy, Liz, additional
- Published
- 2010
- Full Text
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46. Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study.
- Author
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Goldsmith S, McIntyre S, Scott H, Himmelmann K, Smithers-Sheedy H, Andersen GL, Blair E, Badawi N, and Garne E
- Subjects
- Australia epidemiology, Child, Child, Preschool, Female, Humans, Information Storage and Retrieval, Male, Prevalence, Registries, Cerebral Palsy epidemiology, Congenital Abnormalities epidemiology
- Abstract
Aim: To describe the major congenital anomalies present in children with postneonatally acquired cerebral palsy (CP), and to compare clinical outcomes and cause of postneonatally acquired CP between children with and without anomalies., Method: Data were linked between total population CP and congenital anomaly registers in five European and three Australian regions for children born 1991 to 2009 (n=468 children with postneonatally acquired CP; 255 males, 213 females). Data were pooled and children classified into mutually exclusive categories based on type of congenital anomaly. The proportion of children with congenital anomalies was calculated. Clinical outcomes and cause of postneonatally acquired CP were compared between children with and without anomalies., Results: Major congenital anomalies were reported in 25.6% (95% confidence interval [CI] 21.7-29.9) of children with postneonatally acquired CP. Cardiac anomalies, often severe, were common and present in 14.5% of children with postneonatally acquired CP. Clinical outcomes were not more severe in children with congenital anomalies than those without anomalies. Cause of postneonatally acquired CP differed with the presence of congenital anomalies, with cerebrovascular accidents predominating in the anomaly group. Congenital anomalies were likely associated with cause of postneonatally acquired CP in 77% of children with anomalies., Interpretation: In this large, international study of children with postneonatally acquired CP, congenital anomalies (particularly cardiac anomalies) were common. Future research should determine specific causal pathways to postneonatally acquired CP that include congenital anomalies to identify opportunities for prevention., What This Paper Adds: One-quarter of children with postneonatally acquired cerebral palsy (CP) have a major congenital anomaly. Cardiac anomalies, often severe, are the most common anomalies. Causes of postneonatally acquired CP differ between children with and without congenital anomalies., (© 2021 Mac Keith Press.)
- Published
- 2021
- Full Text
- View/download PDF
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