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105 results on '"Goldring CE"'

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1. The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

2. Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

3. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome

4. Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling

5. Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models.

6. A systems approach reveals species differences in hepatic stress response capacity.

7. A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers.

8. Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.

9. Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening.

10. Safety perspectives on presently considered drugs for the treatment of COVID-19.

11. Critical considerations for targeting colorectal liver metastases with nanotechnology.

12. Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

13. Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research.

14. Exosomal Transport of Hepatocyte-Derived Drug-Modified Proteins to the Immune System.

15. Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.

17. Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development.

18. Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.

19. Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.

20. The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

21. Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.

22. NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.

23. Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.

24. Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management.

25. MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury.

26. Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.

27. Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo.

29. A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat.

30. Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.

31. Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies.

32. Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.

33. A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.

34. Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.

35. Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.

36. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.

37. Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.

38. Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.

39. Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.

40. Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study.

41. Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies.

43. MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.

44. Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.

45. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.

46. Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials.

47. The role of ERK5 in endothelial cell function.

48. Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.

49. Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids.

50. Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity.

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