4,717 results on '"Goldman J"'
Search Results
2. Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease
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Schonhoff, A. M., Figge, D. A., Williams, G. P., Jurkuvenaite, A., Gallups, N. J., Childers, G. M., Webster, J. M., Standaert, D. G., Goldman, J. E., and Harms, A. S.
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- 2023
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3. Current status and recent advances in magnesium-matrix syntactic foams: Preparation, mechanical properties, and corrosion behavior
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Motaharinia, A., Drelich, J.W., Goldman, J., Bakhsheshi-Rad, H.R., Sharif, S., Ismail, A.F., and Razzaghi, M.
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- 2024
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4. Magnesium-based nanocomposites: A review from mechanical, creep and fatigue properties
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Abazari, S., Shamsipur, A., Bakhsheshi-Rad, H.R., Drelich, J.W., Goldman, J., Sharif, S., Ismail, A.F., and Razzaghi, M.
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- 2023
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5. Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort
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Heuer, Hilary W, Wang, P, Rascovsky, K, Wolf, A, Appleby, B, Bove, J, Bordelon, Y, Brannelly, P, Brushaber, DE, Caso, C, Coppola, G, Dickerson, B, Dickinson, S, Domoto‐Reilly, K, Faber, K, Ferrall, J, Fields, J, Fishman, A, Fong, J, Foroud, T, Forsberg, LK, Gearhart, D, Ghazanfari, B, Ghoshal, N, Goldman, J, Graff‐Radford, J, Graff‐Radford, N, Grant, I, Grossman, M, Haley, D, Hsiung, G‐Y, Huey, E, Irwin, D, Jones, D, Kantarci, K, Karydas, A, Kaufer, D, Kerwin, D, Knopman, D, Kornak, J, Kramer, JH, Kraft, R, Kremers, WK, Kukull, W, Litvan, I, Ljubenkov, P, Mackenzie, IR, Maldonado, M, Manoochehri, M, McGinnis, S, McKinley, E, Mendez, MF, Miller, BL, Onyike, C, Pantelyat, A, Pearlman, R, Petrucelli, L, Potter, M, Rademakers, R, Ramos, EM, Rankin, KP, Roberson, ED, Rogalski, E, Sengdy, P, Shaw, L, Syrjanen, J, Tartaglia, MC, Tatton, N, Taylor, J, Toga, A, Trojanowski, J, Weintraub, S, Wong, B, Wszolek, Z, Boeve, BF, Rosen, HJ, Boxer, AL, and consortia, on behalf of the ARTFL and LEFFTDS
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Acquired Cognitive Impairment ,Frontotemporal Dementia (FTD) ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurodegenerative ,Alzheimer's Disease Related Dementias (ADRD) ,Behavioral and Social Science ,Clinical Research ,Rare Diseases ,Dementia ,Brain Disorders ,Aging ,Genetics ,Neurological ,Age Factors ,Aged ,Brain ,C9orf72 Protein ,Female ,Frontotemporal Dementia ,Genetic Predisposition to Disease ,Humans ,Male ,Middle Aged ,Mutation ,Neuropsychological Tests ,North America ,Progranulins ,tau Proteins ,bvFTD ,C9orf72 ,clinical trials ,frontotemporal dementia ,genetics ,GRN ,MAPT ,ARTFL and LEFFTDS consortia ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionBehavioral variant frontotemporal dementia (bvFTD) may present sporadically or due to an autosomal dominant mutation. Characterization of both forms will improve understanding of the generalizability of assessments and treatments.MethodsA total of 135 sporadic (s-bvFTD; mean age 63.3 years; 34% female) and 99 familial (f-bvFTD; mean age 59.9; 48% female) bvFTD participants were identified. f-bvFTD cases included 43 with known or presumed chromosome 9 open reading frame 72 (C9orf72) gene expansions, 28 with known or presumed microtubule-associated protein tau (MAPT) mutations, 14 with known progranulin (GRN) mutations, and 14 with a strong family history of FTD but no identified mutation.ResultsParticipants with f-bvFTD were younger and had earlier age at onset. s-bvFTD had higher total Neuropsychiatric Inventory Questionnaire (NPI-Q) scores due to more frequent endorsement of depression and irritability.Discussionf-bvFTD and s-bvFTD cases are clinically similar, suggesting the generalizability of novel biomarkers, therapies, and clinical tools developed in either form to the other.
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- 2020
6. Current status and recent developments in magnesium-matrix syntactic foams: Preparation, mechanical properties, and corrosion behavior
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Motaharinia, A., primary, Drelich, J.W., additional, Goldman, J., additional, Bakhsheshi-Rad, H.R., additional, Sharif, S., additional, Ismail, A.F., additional, and Razzaghi, M., additional
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- 2024
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7. Absence of damaging effects of stem cell donation in unrelated donors assessed by FISH and gene variance screening
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Nacheva, E., Ahyee, T., Addada, J., Navarette, C., Pamphilon, D., Regan, F., Pawson, R., Szydlo, R., Goldman, J., Mackinnon, S., Shaw, B. E., and Madrigal, A.
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- 2020
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8. Search for Cosmic Strings in the COSMOS Survey
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Christiansen, J. L., Albin, E., Fletcher, T., Goldman, J., Teng, I. P. W., Foley, M., and Smoot, G. F.
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Astrophysics - Cosmology and Extragalactic Astrophysics - Abstract
We search the COSMOS survey for pairs of galaxies consistent with the gravitational lensing signature of a cosmic string. The COSMOS survey imaged 1.64 square degrees using the Advanced Camera for Surveys (ACS) aboard the Hubble Space Telescope (HST). Our technique includes estimates of the efficiency for finding the lensed galaxy pair. We find no evidence for cosmic strings with a mass per unit length of G mu/c^2 < 3.0E-7 out to redshifts greater than 0.6 and set 95% upper limits. This corresponds to a global 95% upper limit of Omega_string<0.0028.
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- 2010
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9. Optimized Planar Penning Traps for Quantum Information Studies
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Goldman, J. and Gabrielse, G.
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Physics - Atomic Physics - Abstract
A one-electron qubit would offer a new option for quantum information science, including the possibility of extremely long coherence times. One-quantum cyclotron transitions and spin flips have been observed for a single electron in a cylindrical Penning trap. However, an electron suspended in a planar Penning trap is a more promising building block for the array of coupled qubits needed for quantum information studies. The optimized design configurations identified here promise to make it possible to realize the elusive goal of one trapped electron in a planar Penning trap for the first time - a substantial step toward a one-electron qubit.
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- 2010
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10. Towards electron-electron entanglement in Penning traps
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Lamata, L., Porras, D., Cirac, J. I., Goldman, J., and Gabrielse, G.
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Quantum Physics - Abstract
Entanglement of isolated elementary particles other than photons has not yet been achieved. We show how building blocks demonstrated with one trapped electron might be used to make a model system and method for entangling two electrons. Applications are then considered, including two-qubit gates and more precise quantum metrology protocols., Comment: 5 pages, 1 figure, accepted in PRA
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- 2009
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11. Current pre-clinical and clinical advances in the BCR-ABL1-positive and -negative chronic myeloproliferative neoplasms
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Mughal, T. I, Vannucchi, A. M, Soverini, S., Bazeos, A., Tibes, R., Saglio, G., Abdel-Wahab, O., Pardanani, A., Hehlmann, R., Barbui, T., Van Etten, R., Tefferi, A., and Goldman, J. M
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- 2014
12. A New Perspective: Registered Dietitians Implement Adjusted Rate-based Feeding Protocol to Improve Nutrition Outcomes Without Burdening Nurses
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Goldman, J., primary and Binder, K., additional
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- 2023
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13. Search for Cosmic Strings in the GOODS Survey
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Christiansen, J. L., Albin, E., James, K. A., Goldman, J., Maruyama, D., and Smoot, G. F.
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Astrophysics - Abstract
We search Hubble Space Telescope Treasury Program images collected as part of the Great Observatories Origins Deep Survey for pairs of galaxies consistent with the gravitational lensing signature of a cosmic string. Our technique includes estimates of the efficiency for finding the lensed galaxy pair. In the north (south) survey field we find no evidence out to a redshift of greater than 0.5 (0.3) for cosmic strings to a mass per unit length limit of $G\mu<3.0x10^{-7}$ at 95% confidence limits (C.L.). In the combined 314.9 arcmin$^2$ of the north and south survey fields this corresponds to a global limit on $\Omega_{strings}<0.02$. Our limit on $G\mu$ is more than an order of magnitude lower than searches for individual strings in cosmic microwave background (CMB) data. Our limit is higher than other CMB and gravitational wave searches, however, we note that it is less model dependent than these other searches., Comment: 8 pages, 10 figures. Additional efficiencies are included in this version of the paper. It has been accepted for publication in PRD
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- 2008
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14. Precise Measurement of Neutrino and Anti-neutrino Differential Cross Sections
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Tzanov, M., Naples, D., Boyd, S., McDonald, J., Radescu, V., Adams, T., Alton, A., Avvakumov, S., deBarbaro, L., deBarbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Frey, R., Formaggio, J. A., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McFarland, K. S., McNulty, C., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Suwonjandee, N., Tobien, N., Vakili, M., Vaitaitis, A., Yang, U. K., Yu, J., Zeller, G. P., and Zimmerman, E. D.
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High Energy Physics - Experiment - Abstract
The NuTeV experiment at Fermilab has obtained a unique high statistics sample of neutrino and anti-neutrino interactions using its high-energy sign-selected beam. We present a measurement of the differential cross section for charged-current neutrino and anti-neutrino scattering from iron. Structure functions, F_2(x,Q^2) and xF_3(x,Q^2), are determined by fitting the inelasticity, y, dependence of the cross sections. This measurement has significantly improved systematic precision as a consequence of more precise understanding of hadron and muon energy scales., Comment: 27 pages, 12 figures. Source package includes NuTeV data (NuTeVPack); download at http://arxiv.org/e-print/hep-ex/0509010
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- 2005
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15. Off the Mass Shell: Electroweak Physics at NuTeV
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McFarland, K. S., Zeller, G. P., Adams, T., Alton, A., Avvakumov, S., deBarbaro, L., deBarbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Frey, R., Formaggio, J. A., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McDonald, J., McNulty, C., Naples, D., Nienaber, P., Radescu, V., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Suwonjandee, N., Tzanov, M., Vakili, M., Vaitaitis, A., Yang, U. K., Yu, J., and Zimmerman, E. D.
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High Energy Physics - Experiment - Abstract
The NuTeV collaboration has performed precision measurements of the ratio of neutral current to charged current cross-sections in high rate, high energy neutrino and anti-neutrino beams on a dense, primarily steel, target. The separate neutrino and anti-neutrino beams, high statistics, and improved control of other experimental systematics, allow the determination of electroweak parameters with significantly greater precision than past neutrino-nucleon scattering experiments. Our null hypothesis test of the standard model prediction measures sin2thetaW=0.2277+/-0.0013(stat)+/-0.0009(syst), a value which is 3 sigma above the prediction. We discuss possible explanations for and implications of this discrepancy., Comment: 12 pages, 1 figure, submitted to the proceedings of the XXII Physics in Collision Conference
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- 2002
16. A Departure from Prediction: Electroweak Physics at Nutev
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McFarland, K. S., Zeller, G. P., Adams, T., Alton, A., Avvakumov, S., deBarbaro, L., deBarbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Frey, R., Formaggio, J. A., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McDonald, J., McNulty, C., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Suwonjandee, N., Tzanov, M., Vakili, M., Vaitaitis, A., Yang, U. K., Yu, J., and Zimmerman, E. D.
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High Energy Physics - Experiment - Abstract
The NuTeV experiment has performed precision measurements of the ratio of neutral-current to charged-current cross-sections in high rate, high energy neutrino and anti-neutrino beams on a dense, primarily steel, target. The separate neutrino and anti-neutrino beams, high statistics, and improved control of other experimental systematics, allow the determination of electroweak parameters with significantly greater precision than past neutrino-nucleon scattering experiments. Our null hypothesis test of the standard model prediction measures sin2thetaW=0.2277+/-0.0013(stat)+/-0.0009(syst), a value which is 3.0 standard deviations above the prediction. We discuss possible explanations for and implications of this discrepancy., Comment: submitted to the proceedings of Rencontres de la Vallee d'Aoste, March 2002, 16 pages, 5 figures; v2. fix Eqn 9 and delta-N definition
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- 2002
17. A Search for Muon-neutrino to Electron-neutrino and Muon-antineutrino to Electron-antineutrino Oscillations at NuTeV
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Avvakumov, S., Adams, T., Alton, A., deBarbaro, L., deBarbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Frey, R., Formaggio, J. A., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McDonald, J., McFarland, K. S., McNulty, C., Naples, D., Nienaber, P., Radescu, V., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Suwonjandee, N., Tzanov, M., Vakili, M., Vaitaitis, A., Yang, U. K., Yu, J., Zeller, G. P., and Zimmerman, E. D.
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High Energy Physics - Experiment - Abstract
Limits on $\nu_\mu \to \nu_e$ and $\bar\nu_\mu \to \bar\nu_e$ oscillations are extracted using the NuTeV detector with sign-selected $\nu_\mu$ and $\nub_\mu$ beams. In $\nub_\mu$ mode, for the case of $\sin^2 2\alpha = 1$, $\Delta m^2 > 2.6$ ${\rm eV^2}$ is excluded, and for $\Delta m^2 \gg 1000$ ${\rm eV^2}$, $\sin^2 2\alpha > 1.1 \times 10^{-3}$. The NuTeV data exclude the high $\Delta m^2$ end of $\bar\nu_\mu \to \bar\nu_e$ oscillations parameters favored by the LSND experiment without the need to assume that the oscillation parameters for $\nu$ and $\nub$ are the same. We present the most stringent experimental limits for $\nu_\mu (\bar{\nu}_\mu) \to \nu_e (\bar{\nu}_e)$ oscillations in the large $\Delta m^2$ region., Comment: 4 pages, 3 figures. Submitted to Phys. Rev. Letters, UR-1640
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- 2002
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18. A Precise Determination of Electroweak Parameters in Neutrino-Nucleon Scattering
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NuTeV Collaboration, Zeller, G. P., McFarland, K. S., Adams, T., Alton, A., Avvakumov, S., deBarbaro, L., deBarbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Frey, R., Formaggio, J. A., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McDonald, J., McNulty, C., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Suwonjandee, N., Tzanov, M., Vakili, M., Vaitaitis, A., Yang, U. K., Yu, J., and Zimmerman, E. D.
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High Energy Physics - Experiment - Abstract
The NuTeV collaboration has extracted sin^2theta_W from the ratios of neutral current to charged current neutrino and anti-neutrino cross-sections. Our value, sin^2theta_W(on-shell)=0.2277+/-0.0013(stat)+/-0.0009(syst), is three standard deviations above the standard model prediction. We also present a model independent analysis of the same data., Comment: ReVTeX, 5 pp, 1fig; v2. revised SM prediction; v3. more sig. digits in Eqns 6-7, fix error in Eqn 8
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- 2001
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19. An all silicon quantum computer
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Ladd, T. D., Goldman, J. R., Yamaguchi, F., Yamamoto, Y., Abe, E., and Itoh, K. M.
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Quantum Physics ,Condensed Matter - Abstract
A solid-state implementation of a quantum computer composed entirely of silicon is proposed. Qubits are Si-29 nuclear spins arranged as chains in a Si-28 (spin-0) matrix with Larmor frequencies separated by a large magnetic field gradient. No impurity dopants or electrical contacts are needed. Initialization is accomplished by optical pumping, algorithmic cooling, and pseudo-pure state techniques. Magnetic resonance force microscopy is used for readout. This proposal takes advantage of many of the successful aspects of solution NMR quantum computation, including ensemble measurement, RF control, and long decoherence times, but it allows for more qubits and improved initialization., Comment: ReVTeX 4, 5 pages, 2 figures
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- 2001
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20. Observation of an Anomalous Number of Dimuon Events in a High Energy Neutrino Beam
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NuTeV Collaboration, Adams, T., Alton, A., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Frey, R., Formaggio, J. A., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McDonald, J., McNulty, C., McFarland, K. S., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Suwonjandee, N., Tzanov, M., Vakili, M., Vaitaitis, A., Yang, U. K., Yu, J., Zeller, G. P., and Zimmerman, E. D.
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High Energy Physics - Experiment - Abstract
A search for long-lived neutral particles (N^0's) with masses above 2.2 GeV/c^2 that decay into at least one muon has been performed using an instrumented decay channel at the NuTeV experiment at Fermilab. Data were examined for particles decaying into the final states mu mu, mu e, and mu pi. Three mu mu events were observed over an expected Standard Model background of 0.069 +/- 0.010 events; no events were observed in the other modes., Comment: 5 pages, 3 figures, Submitted to Phys. Rev. Lett
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- 2001
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21. B Cell Ligand Discrimination through a Spreading and Contraction Response
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Fleire, S. J., Goldman, J. P., Carrasco, Y. R., Weber, M., Bray, D., and Batista, F. D.
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- 2006
22. Quantum computation in a one-dimensional crystal lattice with NMR force microscopy
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Ladd, T. D., Goldman, J. R., Dana, A., Yamaguchi, F., and Yamamoto, Y.
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Quantum Physics - Abstract
A proposal for a scalable, solid-state implementation of a quantum computer is presented. Qubits are fluorine nuclear spins in a solid crystal of fluorapatite [Ca_5 F(PO_4)_3] with resonant frequencies separated by a large field gradient. Quantum logic is accomplished using nuclear-nuclear dipolar couplings with decoupling and selective recoupling RF pulse sequences. Magnetic resonance force microscopy is used for readout. As many as 300 qubits can be implemented in the laboratory extremes of T=10 mK and B_0=20 T with the existing sensitivity of force microscopy., Comment: RevTeX, 5 pages, 3 figures Some small errors fixed
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- 2000
23. New Measurements of Nucleon Structure Functions from CCFR/NuTeV
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Bodek, A., Yang, U. K., Adams, T., Alton, A., Arroyo, C. G., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bazarko, A. O., Bernstein, R. H., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Formaggio, J. A., Frey, R., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., King, B. J., Kinnel, T., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., and McFarland, K. S.
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High Energy Physics - Experiment - Abstract
We report on the extraction of the structure functions F_2 and Delta xF_3 = xF_3nu-xF_3nub from CCFR neutrino-Fe and antineutrino-Fe differential cross sections. The extraction is performed in a physics model independent (PMI) way. This first measurement for Delta xF_3, which is useful in testing models of heavy charm production, is higher than current theoretical predictions. Within 5% the F_2 (PMI) values measured in neutrino and muon scattering are in agreement with the predictions of Next-to-Leading-Order PDFs (using massive charm production schemes), thus resolving the long-standing discrepancy between the two measurements., Comment: 3 pages, Presented by Arie Bodek at DPF2000 Conference, Columbus, Ohio, Aug. 2000
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- 2000
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24. Observation of Anomalous Dimuon Events in the NuTeV Decay Detector
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NuTeV Collaboration, Adams, T., Alton, A., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Frey, R., Formaggio, J., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McDonald, J., McNulty, C., McFarland, K. S., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Suwonjandee, N., Vakili, M., Vaitaitis, A., Yang, U. K., Yu, J., Zeller, G. P., and Zimmerman, E. D.
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High Energy Physics - Experiment - Abstract
A search for long-lived neutral particles (N^0) which decay into at least one muon has been performed using an instrumented decay channel at the E815 (NuTeV) experiment at Fermilab. The decay channel was composed of helium bags interspersed with drift chambers, and was used in conjunction with the NuTeV neutrino detector to search for N^0 decays. The data were examined for particles decaying into the muonic final states mu mu, mu e, and mu pi. Three mu mu events were observed over an expected background of 0.040 +/- 0.009 events; no events were observed in the other modes. Although the observed events share some characteristics with neutrino interactions, the observed rate is a factor of 75 greater than expected. No Standard Model process appears to be consistent with this observation., Comment: 14 pages, 16 figures, 10 tables
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- 2000
25. New Measurements of Nucleon Structure Functions from the CCFR/NuTeV Collaboration
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Bodek, A., Yang, U. K., Adams, T., Alton, A., Arroyo, C. G., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bazarko, A. O., Bernstein, R. H., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Fleming, B. T., Formaggio, J. A., Frey, R., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., King, B. J., Kinnel, T., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., and McFarland, K. S.
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High Energy Physics - Experiment - Abstract
We report on the extraction of the structure functions F_2 and Delta xF_3 = xF_3nu-xF_3nubar from CCFR neutrino-Fe and antineutrino-Fe differential cross sections. The extraction is performed in a physics model independent (PMI) way. This first measurement for Delta xF_3, which is useful in testing models of heavy charm production, is higher than current theoretical predictions. The F_2 (PMI) values measured in neutrino and muon scattering are in good agreement with the predictions of Next to Leading Order PDFs (using massive charm production schemes), thus resolving the long-standing discrepancy between the two sets of data., Comment: 5 pages. Presented by Arie Bodek at the CIPNAP2000 Conference, Quebec City, May 2000
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- 2000
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26. Feasibility testing of an automated image-capture method to aid dietary recall
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Arab, L, Estrin, D, Kim, DH, Burke, J, and Goldman, J
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Assistive Technology ,Nutrition ,Clinical Research ,Bioengineering ,Adult ,Data Collection ,Diet ,Feasibility Studies ,Female ,Food ,Humans ,Image Processing ,Computer-Assisted ,Male ,Middle Aged ,Nutrition Assessment ,Surveys and Questionnaires ,Young Adult ,dietary assessment ,automated imaging ,24-h recalls ,food frequency questionnaire ,camera phones ,web-based assessment ,Food Sciences ,Human Movement and Sports Sciences ,Nutrition & Dietetics ,Clinical sciences ,Nutrition and dietetics - Abstract
Background/objectivesThe accuracy of dietary recalls might be enhanced by providing participants with photo images of foods they consumed during the test period.Subjects/methodsWe examined the feasibility of a system (Image-Diet Day) that is a user-initiated camera-equipped mobile phone that is programmed to automatically capture and transmit images to a secure website in conjunction with computer-assisted, multipass, 24-h dietary recalls in 14 participants during 2007. Participants used the device during eating periods on each of the three independent days. Image processing filters successfully eliminated underexposed, overexposed and blurry images. The captured images were accessed by the participants using the ImageViewer software while completing the 24-h dietary recall on the following day.ResultsNone of the participants reported difficulty using the ImageViewer. Images were deemed 'helpful' or 'sort of helpful' by 93% of participants. A majority (79%) of users reported having no technical problems, but 71% rated the burden of wearing the device as somewhat to very difficult, owing to issues such as limited battery life, self-consciousness about wearing the device in public and concerns about the field of view of the camera.ConclusionOverall, these findings suggest that automated imaging is a promising technology to facilitate dietary recall. The challenge of managing the thousands of images generated can be met. Smaller devices with a broader field of view may aid in overcoming self-consciousness of the user with using or wearing the device.
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- 2011
27. Search for a 33.9 MeV/c^2 Neutral Particle in Pion Decay
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Formaggio, J. A., Zimmerman, E. D., Adams, T., Alton, A., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Case, S., Conrad, J. M., Drucker, R. B., Fleming, B. T., Frey, R., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McFarland, K. S., McNulty, C., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H. M., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Vakili, M., Vaitaitis, A., Wu, V., Yang, U. K., Yu, J., and Zeller, G . P.
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High Energy Physics - Experiment - Abstract
The E815 (NuTeV) neutrino experiment has performed a search for a 33.9 MeV/c^2 weakly-interacting neutral particle produced in pion decay. Such a particle may be responsible for an anomaly in the timing distribution of neutrino interactions in the KARMEN experiment. E815 has searched for this particle's decays in an instrumented decay region; no evidence for this particle was found. The search is sensitive to pion branching ratios as low as 10^-13., Comment: 4 pages; 5 figures
- Published
- 1999
- Full Text
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28. Evidence for Diffractive Charm Production in nu_mu Fe and nubar_mu Fe Scattering at the Tevatron
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NuTeV Collaboration, Adams, T., Alton, A., Bolton, T., Goldman, J., Goncharov, M., Naples, D., Johnson, R. A., Vakili, M., Wu, V., Conrad, J., Formaggio, J., Koutsoliotas, S., Kim, J. H., McNulty, C., Romosan, A., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Tamminga, B., Vaitaitis, A., Zimmerman, E. D., Bernstein, R. H., Bugel, L., Lamm, M. J., Marsh, W., Nienaber, P., Yu, J., de Barbaro, L., Buchholz, D., Schellman, H., Zeller, G. P., Brau, J., Drucker, R. B., Frey, R., Mason, D., Avvakumov, S., de Barbaro, P., Bodek, A., Budd, H., Harris, D. A., McFarland, K. S., Sakumoto, W. K., and Yang, U. K.
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High Energy Physics - Experiment - Abstract
We present evidence for the diffractive processes nu_mu Fe -> mu^- D_s^+ (D_s^*+) Fe and nubar_mu Fe -> mu^+ D_s^- (D_s^*-) Fe using the Fermilab SSQT neutrino beam and the Lab E neutrino detector. We observe the neutrino trident reactions nu_mu Fe -> nu_mu mu^- mu^+ Fe and nubar_mu Fe -> nubar_mu mu^+ mu^- Fe at rates consistent with Standard Model expectations. We see no evidence for neutral-current production of J/psi via either diffractive or deep inelastic scattering mechanisms., Comment: 13 pages, submitted to Phys. Rev. D, FERMILAB-Pub-99/269-E
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- 1999
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29. Low Q^2 low x structure function analysis of CCFR data for F2
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CCFR Collaboration, Tamminga, B. H., Adams, T., Alton, A., Arroyo, C. G., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bazarko, A. O., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Formaggio, J. A., Frey, R., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Kim, J. H., King, B. J., Kinnel, T., Koutsoliotas, S., Lamm, M. J., Marsh, W., Mason, D., McFarland, K. S., McNulty, C., Mishra, S. R., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Sciulli, F. J., Seligman, W. G., Shaevitz, M. H., Smith, W. H., Spentzouris, P., Stern, E. G., Vakili, M., Vaitaitis, A., Wu, V., Yang, U. K., Yu, J., Zeller, G. P., and Zimmerman, E. D.
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High Energy Physics - Experiment - Abstract
Analyses of structure functions (SFs) from neutrino and muon deep inelastic scattering data have shown discrepancies in F2 for x < 0.1. A new SF analysis of the CCFR collaboration data examining regions in x down to x=.0015 and 0.4 < Q^2 < 1.0 is presented. Comparison to corrected charged lepton scattering results for F2 from the NMC and E665 experiments are made. Differences between muon and neutrino scattering allow that the behavior of F2 from muon scattering could be different from F2 from neutrino scattering as Q^2 approaches zero. Comparisons between F2 muon and F2 neutrino are made in this limit., Comment: 5 pages, 1 figure, to be published in proceedings for PANIC99
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- 1999
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30. Strange Content of the Nucleon (NuTeV)
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NuTeV Collaboration, Adams, T., Alton, A., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Frey, R., Formaggio, J., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Koutsoliotas, S., Kim, J. H., Lamm, M. J., Marsh, W., MASON, D., McNulty, C., McFarland, K. S., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Tamminga, B., Vakili, M., Vaitaitis, A., Wu, V., Yang, U. K., Yu, J., and Zeller, G. P.
- Subjects
High Energy Physics - Experiment - Abstract
The NuTeV experiment uses neutrino deep-inelastic scattering from separate neutrino and anti-neutrino beams to study the structure of the nucleon. Charged-current production of charm is sensitive to the strange content of the nucleon while neutral-current charm production probes the charm content. Preliminary analyses of both topics are presented along with discussion of possible momentum asymmetry in the strange sea., Comment: 10 pages, 7 figures, Workshop on Physics with Electron Polarized Ion Collider
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- 1999
31. Charm Production at NuTeV
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NuTeV Collaboration, Adams, T., Alton, A., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Frey, R., Formaggio, J., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Koutsoliotas, S., Kim, J. H., Lamm, M. J., Marsh, W., Mason, D., McNulty, C., McFarland, K. S., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Tamminga, B., Vakili, M., Vaitaitis, A., Wu, V., Yang, U. K., Yu, J., and Zeller, G. P.
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High Energy Physics - Experiment - Abstract
Neutrino deep-inelastic scattering provides a means to study both the strange and charm content of the nucleon. The NuTeV experiment (Fermilab E-8Neutrino deep-inelastic scattering provides a means to study both the strange and charm content of the nucleon. The NuTeV experiment (Fermilab E-815) takes full advantage of separated neutrino and anti-neutrino beams to probe the nucleon. The strange sea is studied with charged-current charm production resulting in an opposite-signed two muon final state. The charm content of the nucleon is probed via neutral-current charm production creating an event with a single wrong-signed muon. Preliminary results are presented for both analyses., Comment: 4 pages, 3 figures XXXIVth Recontres de Moriond, QCD and High Energy Hadronic Interactions
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- 1999
32. A Measurement of the Weak Mixing Angle in Neutrino-Nucleon Scattering at NuTeV
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Zeller, G. P., Adams, T., Alton, A., Avvakumov, S., deBarbaro, L., deBarbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Formaggio, J., Frey, R., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Koutsoliotas, S., Kim, J. H., Lamm, M. J., Marsh, W., Mason, D., McNulty, C., McFarland, K. S., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Tamminga, B., Vakili, M., Vaitaitis, A., Wu, V., Yang, U. K., and Yu, J.
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High Energy Physics - Experiment - Abstract
The NuTeV experiment at Fermilab presents a determination of the electroweak mixing angle. High purity, large statistics samples of muon-neutrino and muon-antineutrino events allow the use of the Paschos-Wolfenstein relation. This considerably reduces systematic errors associated with charm production and other sources. With Standard Model assumptions, this measurement of sin2thw indirectly determines the W boson mass to a precision comparable to direct measurements from high energy e+e- and p-pbar colliders. NuTeV measures sin^2theta_W (on-shell) = 0.2253 +/- 0.0019(stat) +/- 0.0010(syst) which implies M_W = 80.26 +/- 0.11 GeV., Comment: 7 pages, including 11 figures. To appear in the proceedings of DPF99, Los Angeles, CA, 5-9 Jan 1999
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- 1999
33. Measurement of sin^2 theta_W in nu N Scattering from NuTeV
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NuTeV Collaboration, Johnson, R. A., Adams, T., Alton, A., Avvakumov, S., De Barbaro, L., De Barbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bguel, L., Conrad, J., Drucker, R. B., Frey, R., Goldman, J., Goncharov, M., Harris, D. A., Koutsoliotas, S., Kim, J. H., Lamm, M. J., Marsh, W., Mason, D., McNulty, C., McFarland, K. S., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Vakili, M., Vaitaitis, A., Wu, V., Yang, U. K., Yu, J., and Zeller, G. P.
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High Energy Physics - Experiment - Abstract
We report the measurement of sin^2 theta_W in nu N deep inelastic scattering from the NuTeV experiment. By using separate neutrino and anti-neutrino beams, NuTeV is able to determine sin^2 theta_W with smaller systematic and similar or smaller statistical errors when compared to previous neutrino experiments. NuTeV measures sin^2 theta_W (on-shell) = 0.2253 +/- 0.0019(stat.) +/- 0.0010(sys.), which implies M_W = 80.26 +/- 0.11 GeV/c^2., Comment: 5 pages, 4 figures, Invited talk presented at WIN99, Cape Town, South Africa, 24-30, January, 1999
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- 1999
34. Measurement of sin2thetaW from Neutrino-Nucleon Scattering at NuTeV
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McFarland, K. S., Adams, T., Alton, A., Avvakumov, S., de Barbaro, L., de Barbaro, P., Bernstein, R. H., Bodek, A., Bolton, T., Brau, J., Buchholz, D., Budd, H., Bugel, L., Conrad, J., Drucker, R. B., Frey, R., Goldman, J., Goncharov, M., Harris, D. A., Johnson, R. A., Koutsoliotas, S., Kim, J. H., Lamm, M. J., Marsh, W., Mason, D., McNulty, C., Naples, D., Nienaber, P., Romosan, A., Sakumoto, W. K., Schellman, H., Shaevitz, M. H., Spentzouris, P., Stern, E. G., Vakili, M., Vaitaitis, A., Wu, V., Yang, U. K., Yu, J., and Zeller, G. P.
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High Energy Physics - Experiment - Abstract
We report the measurement of sin2thetaW in neutrino-nucleon deep inelastic scattering from the NuTeV experiment. Using separate neutrino and anti-neutrino beams, NuTeV is able to determine sin2thetaW with low systematic errors by measuring the Paschos-Wolfenstein variable R-minus, a ratio of differences of neutrino and anti-neutrino neutral-current and charged-current cross-sections. NuTeV measures sin2thetaW(on-shell)= 0.2253+/-0.0019(stat)+/-0.0010(syst), which implies a W mass of 80.26+/-0.11 GeV., Comment: To appear in the Proceedings for the XXXIII Rencontres de Moriond. 12 pages, 3 figures
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- 1998
35. Measurement of neutrino oscillation with Kamland: Evidence of spectral distortion
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Araki, T., Eguchi, K., Enomoto, S., Furuno, K., Ichimura, K., Ikeda, H., Inoue, K., Ishihara, K., Iwamoto, T., Kawashima, T., Kishimoto, Y., Koga, M., Koseki, Y., Maeda, T., Mitsui, T., Motoki, M., Nakajima, K., Ogawa, H., Owada, K., Ricol, J.-S., Shimizu, I., Shirai, J., Suekane, F., Suzuki, A., Tada, K., Tajima, O., Tamae, K., Tsuda, Y., Watanabe, H., Busenitz, J., Classen, T., Djurcic, Z., Keefer, G., McKinny, K., Mei, D.-M., Piepke, A., Yakushev, E., Berger, B.E., Chan, Y.D., Decowski, M.P., Dwyer, D.A., Freedman, S.J., Fu, Y., Fujikawa, B.K., Goldman, J., Gray, F., Heeger, K.M., Lesko, K.T., Luk, K.-B., Murayama, H., Poon, A.W.P., Steiner, H.M., Winslow, L.A., Horton-Smith, G.A., Mauger, C., McKeown, R.D., Vogel, P., Lane, C.E., Miletic, T., Gorham, P.W., Guillian, G., Learned, J.G., Maricic, J., Matsuno, S., Pakvasa, S., Dazeley, S., Hatakeyama, S., Rojas, A., Svoboda, R., Dieterle, B.D., Detwiler, J., Gratta, G., Ishii, K., Tolich, N., Uchida, Y., Batygov, M., Bugg, W., Efremenko, Y., Kamyshkov, Y., Kozlov, A., Nakamura, Y., Gould, C.R., Karwowski, H.J., Markoff, D.M., Messimore, J.A., Nakamura, K., Rohm, R.M., Tornow, W., Wendell, R., Young, A.R., Chen, M.-J., Wang, Y.-F., and Piquemal, F.
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Nuclear physics and radiation physics - Published
- 2004
36. First results from KamLAND: Evidence for reactor anti-neutrino disappearance
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Eguchi, K., Enomoto, S., Furuno, K., Goldman, J., Hanada, H., Ikeda, H., Ikeda, K., Inoue, K., Ishihara, K., Itoh, W., Iwamoto, T., Kawaguchi, T., Kawashima, T., Kinoshita, H., Kishimoto, Y., Koga, M., Koseki, Y., Maeda, T., Mitsui, T., Motoki, M., Nakajima, K., Nakajima, M., Nakajima, T., Ogawa, H., Owada, K., Sakabe, T., Shimizu, I., Shirai, J., Suekane, F., Suzuki, A., Tada, K., Tajima, O., Takayama, T., Tamae, K., Watanabe, H., Busenitz, J., Djurcic, Z., McKinny, K., Mei, D.-M., Piepke, A., Yakushev, E., Berger, B.E., Chan, Y.D., Decowski, M.P., Dwyer, D.A., Freedman, S.J., Fu, Y., Fujikawa, B.K., Heeger, K.M., Lesko, K.T., Luk, K.-B., Murayama, H., Nygren, D.R., Okada, C.E., Poon, A.W.P., Steiner, H.M., Winslow, L.A., Horton-Smith, G.A., McKeown, R.D., Ritter, J., Tipton, B., Vogel, P., Lane, C.E., Miletic, T., Gorham, P.W., Guillian, G., Learned, J.G., Maricic, J., Matsuno, S., Pakvasa, S., Dazeley, S., Hatakeyama, S., Murakami, M., Svoboda, R.C., Dieterle, B.D., DiMauro, M., Detwiler, J., Gratta, G., Ishii, K., Tolich, N., Uchida, Y., Batygov, M., Bugg, W., Cohn, H., Efremenko, Y., Kamyshkov, Y., Kozlov, A., Nakamura, Y., Braeckeleer, L. De, Gould, C.R., Karwowski, H.J., Markoff, D.M., Messimore, J.A., Nakamura, K., Rohm, R.M., Tornow, W., Young, A.R., and Wang, Y-F.
- Subjects
KamLAND Reactor Anti-Neutrino Disappearance - Published
- 2002
37. Enterococcus Faecalis Bacteremia: The Driving Force Behind Septic Thrombophlebitis and Cavitary Pneumonia
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Kovalenko, I., primary, Golubykh, K., additional, Malik, M., additional, Shah, C., additional, Amirian, A., additional, and Goldman, J., additional
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- 2023
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38. P088 The evaluation of the 21-gene Breast Recurrence Score assay as a prognostic factor for locoregional recurrence in early breast cancer treated by lumpectomy and intraoperative radiotherapy only
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Leviov, M., primary, Malik, A., additional, Goldman, J., additional, Bitterman, A., additional, Stein, N., additional, and Steiner, M., additional
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- 2023
- Full Text
- View/download PDF
39. Osimertinib as adjuvant therapy in patients with resected EGFRm stage IB-IIIA NSCLC: updated results from ADAURA
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Grohé, C, additional, Tsuboi, M, additional, Wu, Y, additional, John, T, additional, Majem, M, additional, Wang, J, additional, Kato, T, additional, Goldman, J, additional, Kim, S, additional, Yu, C, additional, Vu, H, additional, Mukhametshina, G, additional, Akewanlop, C, additional, de Marinis, F, additional, Shepherd, F, additional, Urban, D, additional, Stachowiak, M, additional, Balanos, A, additional, Huang, X, additional, Herbst, R, additional, and Kern, J, additional
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- 2023
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40. Validation of the Rainbow Model of Integrated Care Measurement Tool in Parkinson's Disease.
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Valentijn, P.P., Eggers, C., Bloem, B.R., Grimes, D., Goldman, J., McGinley, J., Gardner, J., Piemonte, M.E.P., Dahodwala, N., Brennan, L., Iansek, R., Kovacs, N., Parashos, S., Hilel, A., Rajan, R., Valentijn, P.P., Eggers, C., Bloem, B.R., Grimes, D., Goldman, J., McGinley, J., Gardner, J., Piemonte, M.E.P., Dahodwala, N., Brennan, L., Iansek, R., Kovacs, N., Parashos, S., Hilel, A., and Rajan, R.
- Abstract
01 juli 2023, Contains fulltext : 296073.pdf (Publisher’s version ) (Open Access), BACKGROUND: Integrated care is essential for improving the management and health outcomes for people with Parkinson's disease (PD); reliable and objective measures of care integration are few. OBJECTIVE: The aim of this study was to test the psychometric properties of the Rainbow Model of Integrated Care Measurement Tool (RMIC-MT, provider version) for healthcare professionals involved in PD care. METHODS: A cross-sectional survey was administered online to an international network representing 95 neurology centers across 41 countries and 588 healthcare providers. Exploratory factor analysis with principal axis extraction method was used to assess construct validity. Confirmatory factor analysis was used to evaluate model fit of the RMIC-MT provider version. Cronbach's alpha was used to assess the internal consistency reliability. RESULTS: Overall, 371 care providers (62% response rate) participated in this study. No item had psychometric sensitivity problems. Nine factors (professional coordination, cultural competence, triple aims outcome, system coordination, clinical coordination, technical competence, community-centeredness, person-centeredness, and organizational coordination) with 42 items were determined by exploratory factor analysis. Cronbach's alpha ranged from 0.76 (clinical coordination) to 0.94 (system coordination) and showed significant correlation among all items in the scale (>0.4), indicating good internal consistency reliability. The confirmatory factor analysis model passed most goodness-of-fit tests, thereby confirming the factor structure of nine categories with a total of 40 items. CONCLUSIONS: The results provide evidence for the construct validity and other psychometric properties of the provider version of the RMIC-MT to measure integrated care in PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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- 2023
41. Long-term survival with first-line nivolumab plus ipilimumab in patients with advanced non-small-cell lung cancer: a pooled analysis
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Borghaei, H., primary, Ciuleanu, T.-E., additional, Lee, J.-S., additional, Pluzanski, A., additional, Caro, R. Bernabe, additional, Gutierrez, M., additional, Ohe, Y., additional, Nishio, M., additional, Goldman, J., additional, Ready, N., additional, Spigel, D.R., additional, Ramalingam, S.S., additional, Paz-Ares, L.G., additional, Gainor, J.F., additional, Ahmed, S., additional, Reck, M., additional, Maio, M., additional, O’Byrne, K.J., additional, Memaj, A., additional, Nathan, F., additional, Tran, P., additional, Hellmann, M.D., additional, and Brahmer, J.R., additional
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- 2023
- Full Text
- View/download PDF
42. Long-term (180-day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial
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Florescu, S, Stanciu, D, Zaharia, M, Kosa, A, Codreanu, D, Kidwai, A, Masood, S, Kaye, C, Coutts, A, MacKay, L, Summers, C, Polgarova, P, Farahi, N, Fox, E, McWilliam, S, Hawcutt, D, Rad, L, O’Malley, L, Whitbread, J, Jones, D, Dore, R, Saunderson, P, Kelsall, O, Cowley, N, Wild, L, Thrush, J, Wood, H, Austin, K, Bélteczki, J, Magyar, I, Fazekas, Á, Kovács, S, Szőke, V, Donnelly, A, Kelly, M, Smyth, N, O’Kane, S, McClintock, D, Warnock, M, Campbell, R, McCallion, E, Azaiz, A, Charron, C, Godement, M, Geri, G, Vieillard-Baron, A, Johnson, P, McKenna, S, Hanley, J, Currie, A, Allen, B, McGoldrick, C, McMaster, M, Mani, A, Mathew, M, Kandeepan, R, Vignesh, C, TV, B, Ramakrishnan, N, James, A, Elvira, E, Jayakumar, D, Pratheema, R, Babu, S, Ebenezer, R, Krishnaoorthy, S, Ranganathan, L, Ganesan, M, Shree, M, Guilder, E, Butler, M, Cowdrey, K-A, Robertson, M, Ali, F, McMahon, E, Duffy, E, Chen, Y, Simmonds, C, McConnochie, R, O’Connor, C, El-Khawas, K, Richardson, A, Hill, D, Commons, R, Abdelkharim, H, Saxena, M, Muteithia, M, Dobell-Brown, K, Jha, R, Kalogirou, M, Ellis, C, Krishnamurthy, V, O’Connor, A, Thurairatnam, S, Mukherjee, D, Kaliappan, A, Vertue, M, Nicholson, A, Riches, J, Maloney, G, Kittridge, L, Solesbury, A, Ramos, A, Collins, D, Brickell, K, Reid, L, Smyth, M, Breen, P, Spain, S, Curley, G, McEvoy, N, Geoghegan, P, Clarke, J, Silversides, J, McGuigan, P, Ward, K, O’Neill, A, Finn, S, Wright, C, Green, J, Collins, É, Knott, C, Smith, J, Boschert, C, Slieker, K, Ewalds, E, Sanders, A, Wittenberg, W, Geurts, H, Poojara, L, Sara, T, Nand, K, Reeve, B, Dechert, W, Phillips, B, Oritz-Ruiz de Gordoa, L, Affleck, J, Shaikh, A, Murray, A, Ramanan, M, Frakking, T, Pinnell, J, Robinson, M, Gledhill, L, Wood, T, Sanghavi, R, Bhonagiri, D, Ford, M, Parikh, HG, Avard, B, Nourse, M, McDonald, B, Edmunds, N, Hoiting, O, Peters, M, Rengers, E, Evers, M, Prinssen, A, Morgan, M, Cole, J, Hill, H, Davies, M, Williams, A, Thomas, E, Davies, R, Wise, M, Grimm, P, Soukup, J, Wetzold, R, Löbel, M, Starke, L, Lellouche, F, Lizotte, P, Declerq, P, Antoine, M, Stephanie, G, Jean-Pierre, E, François, B, Marion, B, Philippe, R, Pourcine, F, Monchi, M, Luis, D, Mercier, R, Sagnier, A, Verrier, N, Caplin, C, Richecoeu, J, Combaux, D, Siami, S, Aparicio, C, Vautier, S, Jeblaoui, A, Lemaire-Brunel, D, D'Aragon, F, Carbonneau, E, Leblond, J, Plantefeve, G, Leparco, C, Contou, D, Fartoukh, M, Courtin, L, Labbe, V, Voiriot, G, Salhi, S, Chassé, M, Carrier, F, Boumahni, D, Benettaib, F, Ghamraoui, A, Sement, A, Gachet, A, Hanisch, A, Haffiane, A, Boivin, A-H, Barreau, A, Guerineau, E, Poupblanc, S, Egreteau, P, Lefevre, M, Bocher, S, Le Loup, G, Le Guen, L, Carn, V, Bertel, M, Antcliffe, D, Templeton, M, Rojo, R, Coghlan, P, Smee, J, Barker, G, Finn, A, Kreb, G, Hoff, U, Hinrichs, C, Nee, J, Mackay, E, Cort, J, Whileman, A, Spencer, T, Spittle, N, Beavis, S, Padmakumar, A, Dale, K, Hawes, J, Moakes, E, Gascoyne, R, Pritchard, K, Stevenson, L, Cooke, J, Nemeth-Roszpopa, K, Gauli, B, Bastola, S, Muller, G, Nay, M-A, Kamel, T, Benzekri, D, Jacquier, S, Runge, I, Mathonnet, A, Barbier, F, Bretagnol, A, Carter, J, Van Der Heyden, K, Mehrtens, J, Morris, A, Morgan, S, Burke, T, Mercier, E, Chartier, D, Salmon, C, Dequin, P-F, Garot, D, Bellemare, D, Cloutier, È, Daher, R, Costerousse, O, Boulanger, M-C, Couillard-Chénard, É, Lauzier, F, Francoeur, C, Francois, B, Gay, A, Anne-Laure, F, Ramali, M, HC, O, Ghosh, A, Osagie, R, Arachchige, M, Hartley, M, Cheung, W, Wong, H, Seigne, P, Eustace, J, O'Callaghan, A-M, O'Brien, F, Bamford, P, Reid, A, Cawley, K, Faulkner, M, Pickering, C, Raj, A, Tsinaslanidis, G, Khade, R, Agha, G, Sekiwala, R, Smith, T, Brewer, C, Gregory, J, Limb, J, Cowton, A, O’Brien, J, Postlethwaite, K, Malakouti, S, Music, E, Ricketts, D, King, A, Clermont, G, Bart, R, Mayr, F, Schoenling, A, Andreae, M, Shetty, V, Brant, E, Malley, B, Donadee, C, Sackrowitz, R, Weissman, A, Yealy, D, Barton, D, Talia, N, Nikitas, N, Wells, 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Bowen, D, Kong, J, Joy, J, Fuchs, R, Lambert, B, Tai, C, Thomas, A, Keen, A, Tierney, C, Omer, N, Bacon, G, Tridente, A, Shuker, K, Anders, J, Greer, S, Scott, P, Millington, A, Buchanan, P, Binnie, A, Powell, E, McMillan, A, Luk, T, Aref, N, Denmade, C, Sadera, G, Jacob, R, Hughes, D, Sterba, M, Geng, W, Digby, S, Southern, D, Reddy, H, Hulse, S, Campbell, A, Garton, M, Watkins, C, Smuts, S, Quinn, A, Simpson, B, McMillan, C, Finch, C, Hill, C, Cooper, J, Budd, J, Small, C, O’Leary, R, Collins, E, Holland, A, Alexander, P, Felton, T, Ferguson, S, Sellers, K, Ward, L, Yates, D, Birkinshaw, I, Kell, K, Scott, Z, Pearson, H, Hashmi, M, Hassan, N, Panjwani, A, Umrani, Z, Shaikh, M, Ain, Q, Kanwal, D, Van Bree, S, Bouw-Ruiter, M, Osinga, M, Van Zanten, A, McEldrew, R, Rashan, S, Singh, V, Azergui, N, Bari, S, Beltran, M, Brugman, C, Groeneveld, E, Jafarzadeh, M, Keijzer-Timmers, N, Kester, E, Koelink, M, Kwakkenbos-Craanen, M, Okundaye, C, Parker, L, Peters, S, Post, S, Rietveld, I, Scheepstra-Beukers, I, Schreuder, G, Smit, A, Brillinger, N, Markgraf, R, Eichinger, F, Doran, P, Anjum, A, Best-Lane, J, Barton, F, Miller, L, Richards-Belle, A, Saull, M, Sprinckmoller, S, Wiley, D, Darnell, R, Au, C, Lindstrum, K, Cheng, A, Forbes, A, Heritier, S, Trapani, T, Cuthbertson, B, Manoharan, V, Dondrop, A, Tolppa, T, Ehrmann, S, Hullegie, S, Povoa, P, Beasley, R, Daneman, N, McGloughlin, S, Paterson, D, Venkatesh, B, De Jong, M, Uyeki, T, Baillie, K, Netea, M, Orr, K, Patanwala, A, Tong, S, Cooper, N, Galea, J, Leavis, H, Ogungbenro, K, Patawala, A, Rademaker, E, Youngstein, T, Carrier, M, Fergusson, D, Hunt, B, Kumar, A, Laffan, M, Lother, S, Middeldorp, S, Stanworth, S, De Man, A, Masse, M-H, Abraham, J, Arnold, D, Begin, P, Charlewood, R, Chasse, M, Coyne, M, Daly, J, Gosbell, I, Harvala-Simmonds, H, MacLennan, S, McDyer, J, Menon, D, Pridee, N, Roberts, D, Thomas, H, Tinmouth, A, Triulzi, D, Walsh, T, Wood, E, Calfee, C, O’Kane, C, Shyamsundar, M, Sinha, P, Thompson, T, Young, I, Burrell, A, Ferguson, N, Hodgson, C, Orford, N, Phua, J, Baron, R, Epelman, S, Frankfurter, C, Gommans, F, Kim, E, Leaf, D, Vaduganathan, M, Van Kimmenade, R, Sanil, A, Van Beurden, M, Effelaar, E, Schotsman, J, Boyd, C, Harland, C, Shearer, A, Wren, J, Attanayaka, U, Darshana, S, Ishani, P, Udayanga, I, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z, Mouncey, PR, Al-Beidh, F, Annane, D, Arabi, YM, Beane, A, Van Bentum-Puijk, W, Bhimani, Z, Bonten, MJM, Bradbury, CA, Brunkhorst, FM, Buzgau, A, Buxton, M, Charles, WN, Cove, M, Detry, MA, Estcourt, LJ, Fagbodun, EO, Fitzgerald, M, Girard, TD, Goligher, EC, Goossens, H, Haniffa, R, Hills, T, Horvat, CM, Huang, DT, Ichihara, N, Lamontagne, F, Marshall, JC, McAuley, DF, McGlothlin, A, McGuinness, SP, McVerry, BJ, Neal, MD, Nichol, AD, Parke, RL, Parker, JC, Parry-Billings, K, Peters, SEC, Reyes, LF, Rowan, KM, Saito, H, Santos, MS, Saunders, CT, Serpa-Neto, A, Seymour, CW, Shankar-Hari, M, Stronach, LM, Turgeon, AF, Turner, AM, Van de Veerdonk, FL, Zarychanski, R, Green, C, Lewis, RJ, Angus, DC, McArthur, CJ, Berry, S, Derde, LPG, Gordon, AC, Webb, SA, Lawler, PR, Comm REMAP-CAP Investigators, Apollo - University of Cambridge Repository, Intensive Care Medicine, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pittsburgh Foundation, PF, Amgen, Health Research Board, HRB: CTN 2014-012, Horizon 2020 Framework Programme, H2020: 101003589, Translational Breast Cancer Research Consortium, TBCRC, Canadian Institutes of Health Research, IRSC: 158584, Heart and Stroke Foundation of Canada, HSF, National Institute for Health and Care Research, NIHR, European Commission, EC, National Health and Medical Research Council, NHMRC: 1101719, APP194811, CS-2016-16-011, GNT2008447, RP-2015-06-18, Office of Health and Medical Research, OHMR, Health Research Council of New Zealand, HRC: 16/631, Eisai, Ministère des Affaires Sociales et de la Santé: PHRC-20-0147, Université Pierre et Marie Curie, UPMC, NIHR Imperial Biomedical Research Centre, BRC, Minderoo Foundation, Funding/Support : The Platform for European Preparedness Against (Re-) emerging Epidemics (PREPARE) consortium by the European Union, FP7-HEALTH-2013-INNOVATION-1 (#602525), the Rapid European COVID-19 Emergency Research response (RECOVER) consortium by the European Union’s Horizon 2020 research and innovation programme (#101003589), the Australian National Health and Medical Research Council (#APP1101719), the Australian Medical Research Future Fund (#APP2002132), the Health Research Council of New Zealand (#16/631), the Canadian Institutes of Health Research Strategy for Patient-Oriented Research Innovative Clinical Trials Program Grant (#158584) and the Canadian Institute of Health Research COVID-19 Rapid Research Funding (#447335), the UK National Institute for Health Research (NIHR) and the NIHR Imperial Biomedical Research Centre, the Health Research Board of Ireland (CTN 2014-012), the UPMC Learning While Doing Program, the Translational Breast Cancer Research Consortium, the French Ministry of Health (PHRC-20-0147), the Wellcome Trust Innovations Project (215522), the Minderoo Foundation, the EU Programme Emergency Support Instrument, the NHS Blood and Transplant Research and Development Programme, the Translational Breast Cancer Research Consortium, the NSW Office of Health and Medical Research, Amgen, Eisai, and the Pittsburgh Foundation. Dr Higgins is funded by an NHMRC Emerging Leadership Fellowship (GNT2008447). Dr McQuilten is funded by an NHMRC Emerging Leadership Fellowship (APP194811). Dr Gordon is funded by an NIHR Research Professorship (RP-2015-06-18) and Dr Shankar-Hari by an NIHR Clinician Scientist Fellowship (CS-2016-16-011). Dr Turgeon is the Chairholder of the Canada Research Chair in Critical Care Neurology and Trauma. Dr Lawler is supported by a career award from the Heart and Stroke Foundation of Canada., and European Project: 602525,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,PREPARE(2014)
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Adult ,Male ,corticosteroid ,[SDV]Life Sciences [q-bio] ,Critical Illness ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,antiplatelet ,Lopinavir ,Adaptive platform trial randomized controlled trial intensive care, pneumonia COVID-19 antiplatelet immunoglobulin antiviral corticosteroid immune modulation anticoagulation ,All institutes and research themes of the Radboud University Medical Center ,Adrenal Cortex Hormones ,Humans ,anticoagulation ,intensive care, pneumonia ,COVID-19 Serotherapy ,Original Investigation ,Medicine(all) ,immune modulation ,Ritonavir ,SARS-CoV-2 ,COVID-19 ,Anticoagulants ,Bayes Theorem ,General Medicine ,Middle Aged ,antiviral ,Receptors, Interleukin-6 ,Adaptive platform trial ,randomized controlled trial ,Female ,Human medicine ,immunoglobulin ,Follow-Up Studies ,Hydroxychloroquine - Abstract
ImportanceThe longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.ObjectiveTo determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.Design, Setting, and ParticipantsPrespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022.InterventionsPatients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401).Main Outcomes and MeasuresThe main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83.ResultsAmong 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR >0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies.Conclusions and RelevanceAmong critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months.
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- 2023
43. Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.
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Goldman, J, Spencer, D, and RAULET, David H.
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Animals ,Base Sequence ,DNA ,Gene Rearrangement ,gamma-Chain T-Cell Antigen Receptor ,Mice ,Mice ,Inbred BALB C ,Molecular Sequence Data ,Receptors ,Antigen ,T-Cell ,gamma-delta ,Thymus Gland ,Transcription ,Genetic - Abstract
T cell receptor V gamma genes rearrange to the J gamma 1 gene segment in a highly ordered fashion during development. We demonstrate a striking correlation between the pattern of expression of unrearranged V gamma genes and the timing of their rearrangement. Thus, the increases in V gamma 2 rearrangements, and decreases in V gamma 3 and V gamma 4 rearrangements observed during development are paralleled by increasing or decreasing levels of the corresponding unrearranged V gene transcript. We also provide evidence that both the V gamma 3 and V gamma 4 genes are accessible in mature V gamma 3+ cells, but that the V gamma 4 gene may be inaccessible in the progenitors of V gamma 3 cells. The results suggest that regulated local accessibility of the chromatin surrounding V gamma genes is responsible for ordered V gamma gene rearrangement during development.
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- 1993
44. Incidence of Radiation Pneumonitis Among Patients Treated with Concurrent Thoracic Radiotherapy and Osimertinib for Metastatic Non-Small Cell Lung Cancer
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Smith, C.P., primary, Abtin, F., additional, Xiang, M., additional, Yoon, S., additional, Ruan, D., additional, Goldman, J., additional, Cummings, A.L., additional, Lisberg, A.E., additional, Garon, E., additional, Barjaktarevic, I., additional, and Moghanaki, D., additional
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- 2022
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45. iSABR: Safety and Efficacy Results from a Phase II Study of SABR in Combination with Durvalumab for Early-Stage Medically Inoperable NSCLC
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Lee, P., primary, Stube, A., additional, Felix, C., additional, Oseguera, D., additional, Romero, T., additional, Goldman, J., additional, Garon, E., additional, Lee, J.M., additional, Glaspy, J., additional, Lisberg, A.E., additional, Jr, C. G. Rusthoven, additional, Camidge, D.R., additional, Siva, S., additional, Solomon, B., additional, Lee, A., additional, Tenn, S.E., additional, Shaverdian, N., additional, Steinberg, M.L., additional, and Raldow, A., additional
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- 2022
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46. PP296 [Quality and Safety » Data Management (EHR, documentation)]: USE OF REAL TIME DATA FROM EMR IMPROVES COMPLIANCE WITH STANDARD OF CARE
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Attaar, S. J., primary, Goldman, J., additional, and Kennedy, C., additional
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- 2022
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47. LBA5 Long-term tolerability of adjuvant osimertinib in patients with resected EGFR-mutated (EGFRm) stage IB–IIIA non-small cell lung cancer (NSCLC) from ADAURA
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John, T., primary, Grohe, C., additional, Goldman, J., additional, De Marinis, F., additional, Kato, T., additional, Wang, Q., additional, Choi, J-H., additional, Melotti, B., additional, Fidler, M., additional, Sainsbury, L., additional, Stachowiak, M., additional, Taggart, S., additional, Wu, Y-L., additional, Tsuboi, M., additional, Herbst, R.S., additional, and Majem Tarruella, M., additional
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- 2022
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48. Neratinib efficacy in patients with EGFR exon 18-mutant non-small-cell lung cancer: findings from the SUMMIT basket trial
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Goldman, J., primary, Martínez Bueno, A., additional, Dooms, C., additional, Jhaveri, K., additional, de Miguel, M.J., additional, Piha-Paul, S.A., additional, Unni, N., additional, Mahipal, A., additional, Suga, J.M., additional, Naltet, C., additional, Zick, A., additional, Antoñanzas Basa, M., additional, Crown, J., additional, Chae, Y.K., additional, DiPrimeo, D., additional, Eli, L.D., additional, McCulloch, L., additional, and Mahalingam, D., additional
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- 2022
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49. MA07.05 Phase 1b/2 Study of Combined HER Inhibition in Refractory EGFR-mutated Metastatic Non-small Cell Lung Cancer (NSCLC)
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Goldman, J., primary, Huang, H.K.T., additional, Cummings, A., additional, Noor, Z., additional, Slomowitz, S., additional, Kirimis, E., additional, Olevsky, O., additional, Arzoo, K., additional, Ashouri, S., additional, DiCarlo, B., additional, Hu, E.H.-L., additional, Wong, D.J., additional, Chauv, J., additional, Garon, E.B., additional, Yarden, Y., additional, and Slamon, D., additional
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- 2022
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50. P1.06-01 Adjuvant Osimertinib vs Placebo in Completely Resected Stage IA2-IA3 EGFR-mutated NSCLC: The ADAURA2 Phase III Study
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Goldman, J., primary, Tsutani, Y., additional, Dacic, S., additional, Yatabe, Y., additional, Majem, M., additional, Huang, X., additional, Chen, A., additional, Van der Gronde, T., additional, and He, J., additional
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- 2022
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