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1. Association of systemic lupus erythematosus standard of care immunosuppressants with glucocorticoid use and disease outcomes: a multicentre cohort study

Author

de Luca Montes, Ricardo Azêdo, Huq, Molla, Godfrey, Timothy, Oon, Shereen, Calderone, Alicia, Kandane-Rathnayake, Rangi, Louthrenoo, Worawit, Luo, Shue-Fen, Jan Wu, Yeong-Jian, Golder, Vera, Lateef, Aisha, Navarra, Sandra V., Zamora, Leonid, Hamijoyo, Laniyati, Sockalingam, Sargunan, An, Yuan, Li, Zhanguo, Katsumata, Yasuhiro, Harigai, Masayoshi, Chan, Madelynn, Goldblatt, Fiona, O’Neill, Sean, Lau, Chak Sing, Cho, Jiacai, Hoi, Alberta, Karyekar, Chetan S., Morand, Eric F., and Nikpour, Mandana

Published
2024
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2. Association of sustained lupus low disease activity state with improved outcomes in systemic lupus erythematosus: a multinational prospective cohort study

Author

Golder, Vera, Kandane-Rathnayake, Rangi, Li, Ning, Louthrenoo, Worawit, Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Luo, Shue Fen, Wu, Yeong-Jian, Navarra, Sandra V, Zamora, Leonid, Li, Zhanguo, Sockalingam, Sargunan, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Basnayake, Duminda, Chan, Madelynn, Kikuchi, Jun, Takeuchi, Tsutomu, Bae, Sang-Cheol, Goldblatt, Fiona, Oon, Shereen, O'Neill, Sean, Ng, Kristine, Law, Annie, Tugnet, Nicola, Kumar, Sunil, Tee, Cherica, Tee, Michael, Ohkubo, Naoaki, Tanaka, Yoshiya, Lau, Chak Sing, Hoi, Alberta, Nikpour, Mandana, and Morand, Eric F

Published
2024
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3. Towards a novel clinical outcome assessment for systemic lupus erythematosus: first outcomes of an international taskforce

Author

Connelly, Kathryn, Eades, Laura E., Koelmeyer, Rachel, Ayton, Darshini, Golder, Vera, Kandane-Rathnayake, Rangi, Gregory, Kate, Brunner, Hermine, Burke, Laurie, Arnaud, Laurent, Askanase, Anca, Aranow, Cynthia, Vital, Ed, Pons-Estel, Guillermo, Dantata, Khadija, Andersen, Jeanette, Cornet, Alain, Buie, Joy, Sun, Ying, Tanaka, Yoshiya, Simon, Lee, Lahoud, Youmna, Friedman, Alan, Kalunian, Kenneth, Zuraw, Qing, Werth, Victoria, Garces, Sandra, and Morand, Eric F.

Published
2023
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4. Impact of low disease activity, remission, and complete remission on flares following tapering of corticosteroids and immunosuppressive therapy in patients with systemic lupus erythematous: a multinational cohort study

Author

Cho, Jiacai, Shen, Liang, Huq, Molla, Kandane-Rathnayake, Rangi, Golder, Vera, Louthrenoo, Worawit, Chen, Yi-Hsing, Hamijoyo, Laniyati, Luo, Shue-Fen, Wu, Yeong-Jian J, Zamora, Leonid, Li, Zhanguo, Sockalingam, Sargunan, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Basnayake, Duminda, Chan, Madelynn, Kikuchi, Jun, Takeuchi, Tsutomu, Bae, Sang-Cheol, Oon, Shereen, O'Neill, Sean, Goldblatt, Fiona, Ng, Kristine Pek Ling, Law, Annie, Tugnet, Nicola, Kumar, Sunil, Tee, Cherica, Tee, Michael, Ohkubo, Naoaki, Tanaka, Yoshiya, Navarra, Sandra V, Lau, Chak Sing, Hoi, Alberta, Morand, Eric F, Nikpour, Mandana, and Lateef, Aisha

Published
2023
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5. Associations of improvement in laboratory tests with clinical outcomes in patients with active systemic lupus erythematosus: a multinational longitudinal cohort study

Author

Connelly, Kathryn, Kandane-Rathnayake, Rangi, Hoi, Alberta, Louthrenoo, Worawit, Hamijoyo, Laniyati, Cho, Jiacai, Lateef, Aisha, Fen Luo, Shue, Wu, Yeong-Jian J, Li, Zhanguo, Navarra, Sandra, Zamora, Leonid, Sockalingam, Sargunan, Hao, Yanjie, Zhang, Zhuoli, Katsumata, Yasuhiro, Harigai, Masayoshi, Oon, Shereen, Chan, Madelynn, Chen, Yi-Hsing, Bae, Sang-Cheol, O'Neill, Sean, Goldblatt, Fiona, Kikuchi, Jun, Takeuchi, Tsutomu, Ling Ng, Kristine Pek, Tugnet, Nicola, Basnayake, B M D B, Ohkubo, Naoaki, Tanaka, Yoshiya, Sing Lau, Chak, Nikpour, Mandana, Golder, Vera, and Morand, Eric F

Published
2022
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6. Lupus low disease activity state and remission and risk of mortality in patients with systemic lupus erythematosus: a prospective, multinational, longitudinal cohort study

Author

Kandane-Rathnayake, Rangi, Golder, Vera, Louthrenoo, Worawit, Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Luo, Shue-Fen, Wu, Yeong-Jian J, Navarra, Sandra V, Zamora, Leonid, Li, Zhanguo, Sockalingam, Sargunan, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Basnayake, B M D B, Chan, Madelynn, Kikuchi, Jun, Takeuchi, Tsutomu, Bae, Sang-Cheol, Oon, Shereen, O'Neill, Sean, Goldblatt, Fiona, Ng, Kristine Pek Ling, Law, Annie, Tugnet, Nicola, Kumar, Sunil, Tee, Cherica, Tee, Michael, Ohkubo, Naoaki, Tanaka, Yoshiya, Yu, DaeYoung, Karyekar, Chetan S, Sing Lau, Chak, Monk, Julie A, Nikpour, Mandana, Hoi, Alberta, and Morand, Eric F

Published
2022
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8. ‘Not at target’: prevalence and consequences of inadequate disease control in systemic lupus erythematosus—a multinational observational cohort study

Author

Kandane-Rathnayake, Rangi, Louthrenoo, Worawit, Hoi, Alberta, Luo, Shue-Fen, Wu, Yeong-Jian J., Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Navarra, Sandra V., Zamora, Leonid, Sockalingam, Sargunan, An, Yuan, Li, Zhanguo, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Kikuchi, Jun, Takeuchi, Tsutomu, Basnayake, B. M. D. B., Chan, Madelynn, Ng, Kristine Pek Ling, Tugnet, Nicola, Kumar, Sunil, Oon, Shereen, Goldblatt, Fiona, O’Neill, Sean, Gibson, Kathryn A., Ohkubo, Naoaki, Tanaka, Yoshiya, Bae, Sang-Cheol, Lau, Chak Sing, Nikpour, Mandana, Golder, Vera, and Morand, Eric F.

Published
2022
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11. Comparison Of Attainment And Protective Effects Of Lupus Low Disease Activity State In Patients With Newly Diagnosed Versus Established SLE.

Author

Golder, Vera, primary, Kandane-Rathnayake, Rangi, additional, Louthrenoo, Worawit, additional, Chen, Yi-Hsing, additional, Cho, Jiacai, additional, Lateef, Aisha, additional, Hamijoyo, Laniyati, additional, Luo, Shue-Fen, additional, Wu, Yeong-Jian J., additional, Navarra, Sandra V., additional, Zamora, Leonid, additional, Li, Zhanguo, additional, Sockalingam, Sargunan, additional, Katsumata, Yasuhiro, additional, Harigai, Masayoshi, additional, Hao, Yanjie, additional, Zhang, Zhuoli, additional, Basnayake, BMDB, additional, Chan, Madelynn, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Bae, Sang-Cheol, additional, Oon, Shereen, additional, O'Neill, Sean, additional, Goldblatt, Fiona, additional, Ng, Kristine (Pek Ling), additional, Law, Annie, additional, Tugnet, Nicola, additional, Kumar, Sunil, additional, Tee, Cherica, additional, Tee, Michael, additional, Ohkubo, Naoaki, additional, Tanaka, Yoshiya, additional, Lau, Chak Sing, additional, Nikpour, Mandana, additional, Hoi, Alberta, additional, and Morand, Eric F., additional

Published
2024
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12. Factors associated with damage accrual in patients with systemic lupus erythematosus with no clinical or serological disease activity: a multicentre cohort study

Author

Apostolopoulos, Diane, Kandane-Rathnayake, Rangi, Louthrenoo, Worawit, Luo, Shue Fen, Wu, Yeong-Jian, Lateef, Aisha, Golder, Vera, Sockalingam, Sargunan, Navarra, Sandra, Zamora, Leonid, Hamijoyo, Laniyati, Katsumata, Yasuhiro, Harigai, Masayoshi, Chan, Madelynn, O'Neill, Sean, Goldblatt, Fiona, Lau, Chak Sing, Li, Zhan Guo, Hoi, Alberta, Nikpour, Mandy, and Morand, Eric

Published
2020
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13. Evaluation of remission definitions for systemic lupus erythematosus: a prospective cohort study

Author

Golder, Vera, Kandane-Rathnayake, Rangi, Huq, Molla, Louthrenoo, Worawit, Luo, Shue Fen, Wu, Yeong-Jian Jan, Lateef, Aisha, Sockalingam, Sargunan, Navarra, Sandra V, Zamora, Leonid, Hamijoyo, Laniyati, Katsumata, Yasuhiro, Harigai, Masayoshi, Chan, Madelynn, O’Neill, Sean, Goldblatt, Fiona, Lau, Chak Sing, Li, Zhan Guo, Hoi, Alberta, Nikpour, Mandana, and Morand, Eric F

Published
2019
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14. Lupus low disease activity state as a treatment endpoint for systemic lupus erythematosus: a prospective validation study

Author

Golder, Vera, Kandane-Rathnayake, Rangi, Huq, Molla, Nim, Hieu T, Louthrenoo, Worawit, Luo, Shue Fen, Wu, Yeong-Jian Jan, Lateef, Aisha, Sockalingam, Sargunan, Navarra, Sandra V, Zamora, Leonid, Hamijoyo, Laniyati, Katsumata, Yasuhiro, Harigai, Masayoshi, Chan, Madelynn, O'Neill, Sean, Goldblatt, Fiona, Lau, Chak Sing, Li, Zhan Guo, Hoi, Alberta, Nikpour, Mandana, and Morand, Eric F

Published
2019
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15. Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study

Author

Katsumata, Yasuhiro, primary, Inoue, Eisuke, additional, Harigai, Masayoshi, additional, Cho, Jiacai, additional, Louthrenoo, Worawit, additional, Hoi, Alberta, additional, Golder, Vera, additional, Lau, Chak Sing, additional, Lateef, Aisha, additional, Chen, Yi-Hsing, additional, Luo, Shue-Fen, additional, Wu, Yeong-Jian Jan, additional, Hamijoyo, Laniyati, additional, Li, Zhanguo, additional, Sockalingam, Sargunan, additional, Navarra, Sandra, additional, Zamora, Leonid, additional, Hao, Yanjie, additional, Zhang, Zhuoli, additional, Chan, Madelynn, additional, Oon, Shereen, additional, Ng, Kristine, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Goldblatt, Fiona, additional, O’Neill, Sean, additional, Tugnet, Nicola, additional, Law, Annie Hui Nee, additional, Bae, Sang-Cheol, additional, Tanaka, Yoshiya, additional, Ohkubo, Naoaki, additional, Kumar, Sunil, additional, Kandane-Rathnayake, Rangi, additional, Nikpour, Mandana, additional, and Morand, Eric F, additional

Published
2024
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16. Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study.

Author

Yasuhiro Katsumata, Eisuke Inoue, Masayoshi Harigai, Jiacai Cho, Louthrenoo, Worawit, Hoi, Alberta, Golder, Vera, Chak Sing Lau, Lateef, Aisha, Yi-Hsing Chen, Luo, Shue-Fen, Yeong-Jian Jan Wu, Laniyati Hamijoyo, Zhanguo Li, Sockalingam, Sargunan, Navarra, Sandra, Zamora, Leonid, Yanjie Hao, Zhuoli Zhang, and Chan, Madelynn

Published
2024
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18. LSO-036 Cluster analysis and subphenotype stratification in lupus erythematosus based on data from the Asia Pacific lupus collaboration cohort (APLC-CASTLE)

Author

Wai Chan, Shirley Chiu, primary, Louthrenoo, Worawit, additional, Hoi, Alberta, additional, Luo, Shue Fen, additional, Wu, Yeong-Jian Jan, additional, Chen, Yi-Hsing, additional, Cho, Jiacai, additional, Lateef, Aisha, additional, Hamijoyo, Laniyati, additional, Navarra, Sandra, additional, Zamora, Leonid, additional, Sockalingam, Sargunan, additional, An, Yuan, additional, Li, Zhanguo, additional, Katsumata, Yasuhiro, additional, Harigai, Masayoshi, additional, Hao, Yanjie, additional, Zhang, Zhuoli, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Basnayake, BMDB, additional, Chan, Madelynn, additional, Ng, Kristine, additional, Tugnet, Nicola, additional, Kumar, Sunil, additional, Oon, Shereen, additional, Goldblatt, Fiona, additional, O’Neill, Sean, additional, Gibson, Kathryn, additional, Ohkubo, Naoaki, additional, Tanaka, Yoshiya, additional, Bae, Sang-Cheol, additional, Kandane-Rathnayake, Rangi, additional, Nikpour, Mandana, additional, Golder, Vera, additional, Morand, Eric, additional, and Lau, Chak Sing, additional

Published
2023
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19. LSO-031 Association of serologic and clinical low disease activity states with outcomes in a large multi-national lupus cohort

Author

Hao, Yanjie, primary, Oon, Shereen, additional, Li, Ning, additional, Louthrenoo, Worawit, additional, Chen, Yi-Hsing, additional, Cho, Jiacai, additional, Lateef, Aisha, additional, Hamijoyo, Laniyati, additional, Luo, Shue Fen, additional, Wu, Yeong-Jian, additional, Navarra, Sandra, additional, Zamora, Leonid, additional, Li, Zhanguo, additional, An, Yuan, additional, Sockalingam, Sargunan, additional, Katsumata, Yasuhiro, additional, Harigai, Masayoshi, additional, Zhang, Zhuoli, additional, Chan, Madelynn, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Bae, Sang-Cheol, additional, Goldblatt, Fiona, additional, O’Neill, Sean, additional, Ng, Kristine, additional, Law, Annie, additional, Basnayake, Duminda, additional, Tugnet, Nicola, additional, Kumar, Sunil, additional, Tee, Michael, additional, Tee, Cherica, additional, Tanaka, Yoshiya, additional, Lau, CS, additional, Golder, Vera, additional, Hoi, Alberta, additional, Kandane-Rathnayake, Rangi, additional, Morand, Eric, additional, and Nikpour, Mandana, additional

Published
2023
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20. LO-033 Towards a novel clinical outcome assessment for systemic lupus erythematosus trials – first outcomes of an international consensus process

Author

Connelly, Kathryn, primary, Eades, Laura, additional, Koelmeyer, Rachel, additional, Ayton, Darshini, additional, Golder, Vera, additional, Kandane-Rathnayake, Rangi, additional, Gregory-Wong, Kate, additional, Brunner, Hermine, additional, Burke, Laurie, additional, Arnaud, Laurent, additional, Askanase, Anca, additional, Aranow, Cynthia, additional, Vital, Edward, additional, Pons-Estel, Guillermo, additional, Dantata, Khadija, additional, Sun, Ying, additional, Tanaka, Yoshiya, additional, Lee, Simon, additional, Lahoud, Youmna, additional, Friedman, Alan, additional, Kalunian, Kenneth, additional, Zuraw, Qing, additional, Werth, Victoria, additional, Garces, Sandra, additional, and Morand, Eric, additional

Published
2023
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21. LO-004 Frequency and determinants of flare and persistently active disease in a large multinational prospective lupus cohort

Author

Hao, Yanjie, primary, Kandane-Rathnayake, Rangi, additional, Li, Ning, additional, Louthrenoo, Worawit, additional, Chen, Yi-Hsing, additional, Cho, Jiacai, additional, Lateef, Aisha, additional, Hamijoyo, Laniyati, additional, Luo, Shue Fen, additional, Wu, Yeong-Jian, additional, Navarra, Sandra, additional, Zamora, Leonid, additional, Li, Zhanguo, additional, An, Yuan, additional, Sockalingam, Sargunan, additional, Katsumata, Yasuhiro, additional, Harigai, Masayoshi, additional, Zhang, Zhuoli, additional, Chan, Madelynn, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Bae, Sang-Cheol, additional, Goldblatt, Fiona, additional, O’Neill, Sean, additional, Ng, Kristine, additional, Law, Annie, additional, Basnayake, Duminda, additional, Tugnet, Nicola, additional, Kumar, Sunil, additional, Tee, Michael, additional, Tee, Cherica, additional, Tanaka, Yoshiya, additional, Lau, CS, additional, Golder, Vera, additional, Hoi, Alberta, additional, Morand, Eric, additional, Oon, Shereen, additional, and Nikpour, Mandana, additional

Published
2023
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22. LSO-080 Machine-learning approach on lupus low disease activity prediction

Author

Faelnar, Nick, primary, Tee, Michael, additional, Tee, Cherica, additional, Caro, Jaime, additional, Solano, Geoffrey, additional, Kandane-Rathnayake, Rangi, additional, Magbitang-Santiago, Angelene Therese, additional, Salido, Evelyn, additional, Golder, Vera, additional, Louthrenoo, Worawit, additional, Chen, Yi-Hsing, additional, Cho, Jiacai, additional, Lateef, Aisha, additional, Hamijoyo, Laniyati, additional, Luo, Shue-Fen, additional, Wu, Yeong-Jian J, additional, Navarra, Sandra, additional, Zamora, Leonid, additional, Li, Zhanguo, additional, Sockalingam, Sargunan, additional, Katsumata, Yasuhiro, additional, Harigai, Masayoshi, additional, Hao, Yanjie, additional, Zhang, Zhuoli, additional, Basnayake, BMDB, additional, Chann, Madelynn, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Bae, Sang-Cheol, additional, Oon, Shereen, additional, O’Neill, Sean, additional, Goldblatt, Fiona, additional, Ng, Kristine, additional, Law, Annie, additional, Tugnet, Nicola, additional, Kumar, Sunil, additional, Ohkubo, Naoaki, additional, Tanaka, Yoshiya, additional, Lau, Chak Sing, additional, Nikpour, Mandana, additional, Hoi, Alberta, additional, and Morand, Eric, additional

Published
2023
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23. LSO-087 Sub-optimal use of anti-malarial therapy for SLE in the Asia Pacific region; observations from the Asia Pacific lupus cohort

Author

Kandane-Rathnayake, Rangi, primary, Hoi, Alberta, additional, Worawit, Louthrenoo, additional, Chen, Yi-Hsing, additional, Cho, Jiacai, additional, Lateef, Aisha, additional, Hamijoyo, Laniyati, additional, Luo, Shue Fen, additional, Wu, Yeong-Jian Jan, additional, Navarra, Sandra, additional, Zamora, Leonid, additional, Li, Zhanguo, additional, Sockalingam, Sargunan, additional, Katsumata, Yasuhiro, additional, Harigai, Masayoshi, additional, Hao, Yanjie, additional, Zhang, Zhuoli, additional, Basnayake, BMDB, additional, Chan, Madelynn, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Oon, Shereen, additional, Bae, Sang-Cheol, additional, O’Neill, Sean, additional, Goldblatt, Fiona, additional, Ng, Kristine (Pek Ling), additional, Nee Law, Annie Hui, additional, Tugnet, Nicola, additional, Kumar, Sunil, additional, Ohkubo, Naoaki, additional, Tee, Michael, additional, Tee, Cherica, additional, Tanaka, Yoshiya, additional, Lau, Chak Sing, additional, Golder, Vera, additional, Nikpour, Mandana, additional, and Morand, Eric, additional

Published
2023
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24. SMART-SLE: serology monitoring and repeat testing in systemic lupus erythematosus—an analysis of anti-double-stranded DNA monitoring.

Author

Yeo, Ai Li, Kandane-Rathnayake, Rangi, Koelmeyer, Rachel, Golder, Vera, Louthrenoo, Worawit, Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Luo, Shue-Fen, Wu, Yeong-Jian J, Navarra, Sandra V, Zamora, Leonid, Li, Zhanguo, An, Yuan, Sockalingam, Sargunan, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, and Zhang, Zhuoli

Subjects
SYSTEMIC lupus erythematosus diagnosis, KRUSKAL-Wallis Test, DNA, CONFIDENCE intervals, ACQUISITION of data, LONGITUDINAL ligaments, RESEARCH funding, CHI-squared test, DESCRIPTIVE statistics, BLOOD testing, LONGITUDINAL method
Abstract

Objective Disease activity monitoring in SLE includes serial measurement of anti-double stranded-DNA (dsDNA) antibodies, but in patients who are persistently anti-dsDNA positive, the utility of repeated measurement is unclear. We investigated the usefulness of serial anti-dsDNA testing in predicting flare in SLE patients who are persistently anti-dsDNA positive. Methods Data were analysed from patients in a multinational longitudinal cohort with known anti-dsDNA results from 2013 to 2021. Patients were categorized based on their anti-dsDNA results as persistently negative, fluctuating or persistently positive. Cox regression models were used to examine longitudinal associations of anti-dsDNA results with flare. Results Data from 37 582 visits of 3484 patients were analysed. Of the patients 1029 (29.5%) had persistently positive anti-dsDNA and 1195 (34.3%) had fluctuating results. Anti-dsDNA expressed as a ratio to the normal cut-off was associated with the risk of subsequent flare, including in the persistently positive cohort (adjusted hazard ratio [HR] 1.56; 95% CI: 1.30, 1.87; P  < 0.001) and fluctuating cohort (adjusted HR 1.46; 95% CI: 1.28, 1.66), both for a ratio >3. Both increases and decreases in anti-dsDNA more than 2-fold compared with the previous visit were associated with increased risk of flare in the fluctuating cohort (adjusted HR 1.33; 95% CI: 1.08, 1.65; P  = 0.008) and the persistently positive cohort (adjusted HR 1.36; 95% CI: 1.08, 1.71; P  = 0.009). Conclusion Absolute value and change in anti-dsDNA titres predict flares, including in persistently anti-dsDNA positive patients. This indicates that repeat monitoring of dsDNA has value in routine testing. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Association of Modified Systemic Lupus Erythematosus Responder Index Attainment With Long‐Term Clinical Outcomes: A Five‐Year Prospective Study

Author

Connelly, Kathryn, primary, Kandane‐Rathnayake, Rangi, additional, Hoi, Alberta, additional, Louthrenoo, Worawit, additional, Hamijoyo, Laniyati, additional, Luo, Shue Fen, additional, Wu, Yeong‐Jian Jan, additional, Cho, Jiacai, additional, Lateef, Aisha, additional, Lau, CS, additional, Chen, Yi‐Hsing, additional, Navarra, Sandra, additional, Zamora, Leonid, additional, Li, Zhanguo, additional, An, Yuan, additional, Sockalingam, Sargunan, additional, Hao, Yanjie, additional, Zhang, Zhuoli, additional, Chan, Madelynn, additional, Katsumata, Yasuhiro, additional, Harigai, Masayoshi, additional, Oon, Shereen, additional, Bae, Sang‐Cheol, additional, O'Neill, Sean, additional, Gibson, Kathryn A., additional, Basnayake, BMDB, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Ng, Kristine Pek Ling, additional, Tugnet, Nicola, additional, Kumar, Sunil, additional, Goldblatt, Fiona, additional, Law, Annie, additional, Tee, Michael, additional, Tee, Cherica, additional, Tanaka, Yoshiya, additional, Ohkubo, Naoaki, additional, Tan, Jin Yu, additional, Karyekar, Chetan S., additional, Nikpour, Mandana, additional, Golder, Vera, additional, and Morand, Eric F., additional

Published
2022
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31. Additional file 3 of ���Not at target���: prevalence and consequences of inadequate disease control in systemic lupus erythematosus���a multinational observational cohort study

Author

Kandane-Rathnayake, Rangi, Louthrenoo, Worawit, Hoi, Alberta, Luo, Shue-Fen, Wu, Yeong-Jian J., Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Navarra, Sandra V., Zamora, Leonid, Sockalingam, Sargunan, An, Yuan, Li, Zhanguo, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Kikuchi, Jun, Takeuchi, Tsutomu, Basnayake, B. M. D. B., Chan, Madelynn, Ng, Kristine Pek Ling, Tugnet, Nicola, Kumar, Sunil, Oon, Shereen, Goldblatt, Fiona, O���Neill, Sean, Gibson, Kathryn A., Ohkubo, Naoaki, Tanaka, Yoshiya, Bae, Sang-Cheol, Lau, Chak Sing, Nikpour, Mandana, Golder, Vera, and Morand, Eric F.

Abstract

Additional file 3: Supplementary Table S3. Associations of SLE unmet need definitions with daily prednisolone dose (mg), adjusted for other potential confounding factors.

Published
2022
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32. Additional file 1 of ���Not at target���: prevalence and consequences of inadequate disease control in systemic lupus erythematosus���a multinational observational cohort study

Author

Kandane-Rathnayake, Rangi, Louthrenoo, Worawit, Hoi, Alberta, Luo, Shue-Fen, Wu, Yeong-Jian J., Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Navarra, Sandra V., Zamora, Leonid, Sockalingam, Sargunan, An, Yuan, Li, Zhanguo, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Kikuchi, Jun, Takeuchi, Tsutomu, Basnayake, B. M. D. B., Chan, Madelynn, Ng, Kristine Pek Ling, Tugnet, Nicola, Kumar, Sunil, Oon, Shereen, Goldblatt, Fiona, O���Neill, Sean, Gibson, Kathryn A., Ohkubo, Naoaki, Tanaka, Yoshiya, Bae, Sang-Cheol, Lau, Chak Sing, Nikpour, Mandana, Golder, Vera, and Morand, Eric F.

Subjects
digestive, oral, and skin physiology, health care economics and organizations
Abstract

Additional file 1: Supplementary Table S1. Associations of SLE unmet need definitions with organ damage accrual, adjusted for other potential confounding factors.

Published
2022
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33. Additional file 4 of ���Not at target���: prevalence and consequences of inadequate disease control in systemic lupus erythematosus���a multinational observational cohort study

Author

Kandane-Rathnayake, Rangi, Louthrenoo, Worawit, Hoi, Alberta, Luo, Shue-Fen, Wu, Yeong-Jian J., Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Navarra, Sandra V., Zamora, Leonid, Sockalingam, Sargunan, An, Yuan, Li, Zhanguo, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Kikuchi, Jun, Takeuchi, Tsutomu, Basnayake, B. M. D. B., Chan, Madelynn, Ng, Kristine Pek Ling, Tugnet, Nicola, Kumar, Sunil, Oon, Shereen, Goldblatt, Fiona, O���Neill, Sean, Gibson, Kathryn A., Ohkubo, Naoaki, Tanaka, Yoshiya, Bae, Sang-Cheol, Lau, Chak Sing, Nikpour, Mandana, Golder, Vera, and Morand, Eric F.

Subjects
humanities
Abstract

Additional file 4: Supplementary Table S4. Associations of SLE unmet need definitions with SF36-PCS, adjusted for other potential confounding factors.

Published
2022
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36. Additional file 5 of ���Not at target���: prevalence and consequences of inadequate disease control in systemic lupus erythematosus���a multinational observational cohort study

Author

Kandane-Rathnayake, Rangi, Louthrenoo, Worawit, Hoi, Alberta, Luo, Shue-Fen, Wu, Yeong-Jian J., Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Navarra, Sandra V., Zamora, Leonid, Sockalingam, Sargunan, An, Yuan, Li, Zhanguo, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Kikuchi, Jun, Takeuchi, Tsutomu, Basnayake, B. M. D. B., Chan, Madelynn, Ng, Kristine Pek Ling, Tugnet, Nicola, Kumar, Sunil, Oon, Shereen, Goldblatt, Fiona, O���Neill, Sean, Gibson, Kathryn A., Ohkubo, Naoaki, Tanaka, Yoshiya, Bae, Sang-Cheol, Lau, Chak Sing, Nikpour, Mandana, Golder, Vera, and Morand, Eric F.

Subjects
humanities
Abstract

Additional file 5: Supplementary Table S5. Associations of SLE unmet need definitions with SF36-MCS, adjusted for other potential confounding factors.

Published
2022
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39. Additional file 4 of Association of clinic setting with quality indicator performance in systemic lupus erythematosus: a cross-sectional study

Author

Sreedharan, Sidha, Li, Ning, Littlejohn, Geoff, Buchanan, Russell, Nikpour, Mandana, Morand, Eric, Hoi, Alberta, and Golder, Vera

Abstract

Additional file 4: Supplementary Table 4. Multivariable regression of per-patient QI performance adjusted for sociodemographic, disease and healthcare determinants.

Published
2022
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40. Additional file 2 of ���Not at target���: prevalence and consequences of inadequate disease control in systemic lupus erythematosus���a multinational observational cohort study

Author

Kandane-Rathnayake, Rangi, Louthrenoo, Worawit, Hoi, Alberta, Luo, Shue-Fen, Wu, Yeong-Jian J., Chen, Yi-Hsing, Cho, Jiacai, Lateef, Aisha, Hamijoyo, Laniyati, Navarra, Sandra V., Zamora, Leonid, Sockalingam, Sargunan, An, Yuan, Li, Zhanguo, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, Zhang, Zhuoli, Kikuchi, Jun, Takeuchi, Tsutomu, Basnayake, B. M. D. B., Chan, Madelynn, Ng, Kristine Pek Ling, Tugnet, Nicola, Kumar, Sunil, Oon, Shereen, Goldblatt, Fiona, O���Neill, Sean, Gibson, Kathryn A., Ohkubo, Naoaki, Tanaka, Yoshiya, Bae, Sang-Cheol, Lau, Chak Sing, Nikpour, Mandana, Golder, Vera, and Morand, Eric F.

Abstract

Additional file 2: Supplementary Table S2. Associations of SLE unmet need definitions with mortality, adjusted for other potential confounding factors.

Published
2022
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43. Fibromyalgia, mood disorders, cognitive test results, cognitive symptoms and quality of life in systemic lupus erythematosus.

Author

Raghunath, Sudha, Guymer, Emma K, Glikmann-Johnston, Yifat, Golder, Vera, Rathnayake, Rangi Kandane, Morand, Eric F, Stout, Julie C, and Hoi, Alberta

Subjects
MENTAL depression risk factors, COGNITION disorders, HEALTH outcome assessment, FIBROMYALGIA, RISK assessment, AFFECTIVE disorders, QUALITY of life, SYSTEMIC lupus erythematosus, COGNITIVE testing, ANXIETY, FATIGUE (Physiology), COMORBIDITY
Abstract

Objectives Cognitive dysfunction, and comorbidities such as mood disorder and fibromyalgia, are common in SLE. This study aims to explore the associations between fibromyalgia, mood disorders, cognitive symptoms and cognitive dysfunction in SLE patients, and their impact on quality of life. Methods We tested cognition in SLE patients and healthy controls, and evaluated cognitive symptoms, mood disorder, fibromyalgia, fatigue and quality of life using patient-reported outcome measures. We examined associations of these comorbidities with both patient-reported cognitive symptoms and cognitive test performance. Results High fibromyalgia symptom score and history of depression or anxiety were associated with cognitive dysfunction. There were no significant associations between current depression, anxiety symptoms or fatigue score and objective cognitive dysfunction. In contrast, mood disorder symptoms, history of mood disorder, fibromyalgia symptoms and fatigue all had significant associations with patient-reported cognitive symptoms. There were no significant associations between patient-reported cognitive symptoms and objective cognitive dysfunction. Objective cognitive dysfunction, patient-reported cognitive symptoms, history of mood disorder and fibromyalgia symptoms all had significant associations with poorer quality of life; fibromyalgia had the biggest impact. Conclusions Cognitive symptoms are common in SLE, but there were no associations between cognitive symptoms and objective cognitive dysfunction. Depression, anxiety and fibromyalgia were more consistently associated with patient-reported cognitive symptoms than with objective cognitive dysfunction. These factors all have a significant impact on quality of life. Understanding the discrepancy between patient-reported cognitive symptoms and cognitive test performance is essential to advance care in this area of unmet need. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Patterns of Medication Use in Systemic Lupus Erythematosus: A Multicenter Cohort Study.

Author

Kandane‐Rathnayake, Rangi, Louthrenoo, Worawit, Luo, Shue‐Fen, Wu, Yeong‐Jian J., Chen, Yi‐Hsing, Golder, Vera, Lateef, Aisha, Cho, Jiacai, Navarra, Sandra V., Zamora, Leonid, Hamijoyo, Laniyati, Sockalingam, Sargunan, An, Yuan, Li, Zhanguo, Montes, Ricardo, Oon, Shereen, Katsumata, Yasuhiro, Harigai, Masayoshi, Hao, Yanjie, and Zhang, Zhuoli

Subjects
SYSTEMIC lupus erythematosus, DRUGS, COHORT analysis, ANTIMALARIALS, IMMUNOSUPPRESSIVE agents
Abstract

Objective: Evidence for the utility of medications in settings lacking randomized trial data can come from studies of treatment persistence. The present study was undertaken to examine patterns of medication use in systemic lupus erythematosus (SLE) using data from a large multicenter longitudinal cohort. Methods: Prospectively collected data from the Asia Pacific Lupus Collaboration cohort including disease activity (SLE Disease Activity Index 2000 [SLEDAI‐2K]) and medication details, captured at every visit from 2013–2018, were used. Medications were categorized as glucocorticoids (GCs), antimalarials (AM), and immunosuppressants (IS). Cox regression analyses were performed to determine the time‐to‐discontinuation of medications, stratified by SLE disease activity. Results: Data from 19,804 visits of 2,860 patients were analyzed. Eight medication categories were observed: no treatment; GC, AM, or IS only; GC plus AM; GC plus IS; AM plus IS; and GC plus AM plus IS (triple therapy). Triple therapy was the most frequent pattern (31.4% of visits); single agents were used in 21% of visits, and biologics in only 3%. Time‐to‐discontinuation analysis indicated that medication persistence varied widely, with the highest treatment persistence for AM and lowest for IS. Patients with a time‐adjusted mean SLEDAI‐2K score of ≥10 had lower discontinuation of GCs and higher discontinuation of IS. Conclusion: Most patients received combination treatment. GC persistence was high, while IS persistence was low. Patients with high disease activity received more medication combinations but had reduced IS persistence, consistent with limited utility. These data confirm unmet need for improved SLE treatments. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Disseminated enteroviral infection associated with obinutuzumab

Author

Dendle, Claire, Gilbertson, Michael, Korman, Tony M., Golder, Vera, Morand, Eric, and Opat, Stephen

Subjects
Care and treatment, Complications and side effects, Research, Risk factors, Dosage and administration, Bacterial infections -- Risk factors -- Care and treatment -- Research, Obinutuzumab -- Dosage and administration -- Complications and side effects -- Research, Lymphomas -- Care and treatment -- Research
Abstract

Viral, fungal, and bacterial infections (1,2) and a recent case of enteroviral meningoencephalitis (3) associated with obinutuzumab use have been described. Early recognition is critical because the infection can be [...]

Published
2015
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49. COVID‐19 infection in patients with systemic lupus erythematosus: Data from the Asia Pacific Lupus Collaboration

Author

Cho, Jiacai, primary, Kandane‐Rathnayake, Rangi, additional, Louthrenoo, Worawit, additional, Hoi, Alberta, additional, Golder, Vera, additional, Chen, Yi‐Hsing, additional, Luo, Shue Fen, additional, Wu, Yeong‐Jian Jan, additional, Hamijoyo, Laniyati, additional, Lau, Chak Sing, additional, Navarra, Sandra, additional, Zamora, Leonid, additional, Tee, Michael, additional, Flora, Angelito, additional, Li, Zhan‐Guo, additional, An, Yuan, additional, Sockalingam, Sargunan, additional, Katsumata, Yasuhiro, additional, Harigai, Masayoshi, additional, Hao, Yanjie, additional, Zhang, Zhuoli, additional, Kikuchi, Jun, additional, Takeuchi, Tsutomu, additional, Basnayake, Duminda, additional, Goldblatt, Fiona, additional, Chan, Madelynn, additional, Ng, Kristine Pek Ling, additional, Bae, Sang‐Cheol, additional, Oon, Shereen, additional, O’Neill, Sean, additional, Gibson, Kathy, additional, Kumar, Sunil, additional, Law, Annie Hui Nee, additional, Tugnet, Nicola, additional, Tanaka, Yoshiya, additional, Nikpour, Mandy, additional, Morand, Eric, additional, and Lateef, Aisha, additional

Published
2020
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50. Measurement of specific organ domains in lupus randomized controlled trials: a scoping review.

Author

Connelly, Kathryn, Vettivel, Jeevan, Golder, Vera, Kandane-Rathnayake, Rangi, and Morand, Eric F

Subjects
SYSTEMIC lupus erythematosus diagnosis, MEDICAL information storage & retrieval systems, INFORMATION storage & retrieval systems, MEDICAL databases, META-analysis, SYSTEMATIC reviews, HEALTH outcome assessment, SYSTEMIC lupus erythematosus, MEDLINE, LITERATURE reviews
Abstract

Objective Randomized controlled trials (RCTs) in SLE (lupus) typically adopt composite responder definitions as primary efficacy endpoints; however, outcomes within individual organ domains are also important to understand. The aim of this scoping review was to evaluate how organ-specific disease activity and therapeutic responses have been measured and reported in lupus RCTs. Methods We searched MEDLINE, EMBASE, Cochrane registry and clinicaltrials.gov. Eligible studies were RCTs investigating efficacy of an immune-directed drug therapy in active SLE, published January 2000–March 2021, excluding studies limited to lupus nephritis. Data were extracted independently in duplicate into a template and summarized descriptively. Results Thirty-four RCTs were included, of which 32 (94%) reported activity and/or responses in at least one organ domain. Study populations had a high, although variable, frequency of baseline musculoskeletal and mucocutaneous activity and low, but also variable, representation of other domains. Definitions of organ-specific responses were inconsistent, even within individual instruments. Response in most organ domains were evaluated using BILAG and SLEDAI components but meaningful comparison between treatment arms was limited by small subgroups analysed in a post hoc fashion. Specific mucocutaneous and arthritis instruments were also used, including within pre-specified organ-specific endpoints, which discriminated between treatment arms in some studies. Conclusion Mucocutaneous and musculoskeletal manifestations predominate in SLE RCTs. Organ-specific outcome measures are commonly reported, but definitions of involvement and response are inconsistent. Research into the development of new outcome measures for key organ domains, and validation and comparison of response definitions using existing instruments, is needed. [ABSTRACT FROM AUTHOR]

Published
2022
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