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1. Evolution of longitudinal plasma-density profiles in discharge capillaries for plasma wakefield accelerators

Author

Garland, J. M., Tauscher, G., Bohlen, S., Boyle, G. J., D'Arcy, R., Goldberg, L., Põder, K., Schaper, L., Schmidt, B., and Osterhoff, J.

Subjects
Physics - Plasma Physics, Physics - Accelerator Physics, Physics - Instrumentation and Detectors
Abstract

Precise characterization and tailoring of the spatial and temporal evolution of plasma density within plasma sources is critical for realizing high-quality accelerated beams in plasma wakefield accelerators. The simultaneous use of two independent diagnostic techniques allowed the temporally and spatially resolved detection of plasma density with unprecedented sensitivity and enabled the characterization of the plasma temperature at local thermodynamic equilibrium in discharge capillaries. A common-path two-color laser interferometer for obtaining the average plasma density with a sensitivity of $2\times 10^{15}$ cm$^{-2}$ was developed together with a plasma emission spectrometer for analyzing spectral line broadening profiles with a resolution of $5\times 10^{15}$ cm$^{-3}$. Both diagnostics show good agreement when applying the spectral line broadening analysis methodology of Gigosos and Carde{\~n}oso. Measured longitudinally resolved plasma density profiles exhibit a clear temporal evolution from an initial flat-top to a Gaussian-like shape in the first microseconds as material is ejected out from the capillary, deviating from the often-desired flat-top profile. For plasma with densities of 0.5-$2.5\times 10^{17}$ cm$^{-3}$, temperatures of 1-7 eV were indirectly measured. These measurements pave the way for highly detailed parameter tuning in plasma sources for particle accelerators and beam optics., Comment: 8 pages, 8 figures, submitted to "Review of Scientific Instruments" (AIP)

Published
2020
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2. FLASHForward: Plasma-wakefield accelerator science for high-average-power applications

Author

D'Arcy, R., Aschikhin, A., Bohlen, S., Boyle, G., Brümmer, T., Chappell, J., Diederichs, S., Foster, B., Garland, M. J., Goldberg, L., Gonzalez, P., Karstensen, S., Knetsch, A., Kuang, P., Libov, V., Ludwig, K., de la Ossa, A. Martinez, Marutzky, F., Meisel, M., Mehrling, T. J., Niknejadi, P., Poder, K., Pourmoussavi, P., Quast, M., Röckemann, J. -H., Schaper, L., Schmidt, B., Schröder, S., Schwinkendorf, J. -P., Sheeran, B., Tauscher, G., Wesch, S., Wing, M., Winkler, P., Zeng, M., and Osterhoff, J.

Subjects
Physics - Accelerator Physics, Physics - Plasma Physics
Abstract

The FLASHForward experimental facility is a high-performance test-bed for precision plasma-wakefield research, aiming to accelerate high-quality electron beams to GeV-levels in a few centimetres of ionised gas. The plasma is created by ionising gas in a gas cell either by a high-voltage discharge or a high-intensity laser pulse. The electrons to be accelerated will either be injected internally from the plasma background or externally from the FLASH superconducting RF front end. In both cases the wakefield will be driven by electron beams provided by the FLASH gun and linac modules operating with a 10 Hz macro-pulse structure, generating 1.25 GeV, 1 nC electron bunches at up to 3 MHz micro-pulse repetition rates. At full capacity, this FLASH bunch-train structure corresponds to 30 kW of average power, orders of magnitude higher than drivers available to other state-of-the-art LWFA and PWFA experiments. This high-power functionality means FLASHForward is the only plasma-wakefield facility in the world with the immediate capability to develop, explore, and benchmark high-average-power plasma-wakefield research essential for next-generation facilities. The operational parameters and technical highlights of the experiment are discussed, as well as the scientific goals and high-average-power outlook.

Published
2019
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3. A tunable plasma-based energy dechirper

Author

D'Arcy, R., Wesch, S., Aschikhin, A., Bohlen, S., Behrens, C., Garland, M. J., Goldberg, L., Gonzalez, P., Knetsch, A., Libov, V., de la Ossa, A. Martinez, Meisel, M., Mehrling, T. J., Niknejadi, P., Poder, K., Roeckemann, J. -H., Schaper, L., Schmidt, B., Schroeder, S., Palmer, C., Schwinkendorf, J. -P., Sheeran, B., Streeter, M. J. V., Tauscher, G., Wacker, V., and Osterhoff, J.

Subjects
Physics - Plasma Physics, Physics - Accelerator Physics
Abstract

A tunable plasma-based energy dechirper has been developed at FLASHForward to remove the correlated energy spread of a 681~MeV electron bunch. Through the interaction of the bunch with wakefields excited in plasma the projected energy spread was reduced from a FWHM of 1.31$\%$ to 0.33$\%$ without reducing the stability of the incoming beam. The experimental results for variable plasma density are in good agreement with analytic predictions and three-dimensional simulations. The proof-of-principle dechirping strength of $1.8$~GeV/mm/m significantly exceeds those demonstrated for competing state-of-the-art techniques and may be key to future plasma wakefield-based free-electron lasers and high energy physics facilities, where large intrinsic chirps need to be removed.

Published
2018
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5. Tunable Plasma-Based Energy Dechirper

Author

D'Arcy, R, Wesch, S, Aschikhin, A, Bohlen, S, Behrens, C, Garland, MJ, Goldberg, L, Gonzalez, P, Knetsch, A, Libov, V, de la Ossa, A Martinez, Meisel, M, Mehrling, TJ, Niknejadi, P, Poder, K, Röckemann, J-H, Schaper, L, Schmidt, B, Schröder, S, Palmer, C, Schwinkendorf, J-P, Sheeran, B, Streeter, MJV, Tauscher, G, Wacker, V, and Osterhoff, J

Subjects
Nuclear and Plasma Physics, Physical Sciences, Affordable and Clean Energy, physics.plasm-ph, physics.acc-ph, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract

A tunable plasma-based energy dechirper has been developed at FLASHForward to remove the correlated energy spread of a 681 MeV electron bunch. Through the interaction of the bunch with wakefields excited in plasma the projected energy spread was reduced from a FWHM of 1.31% to 0.33% without reducing the stability of the incoming beam. The experimental results for variable plasma density are in good agreement with analytic predictions and three-dimensional simulations. The proof-of-principle dechirping strength of 1.8  GeV/mm/m significantly exceeds those demonstrated for competing state-of-the-art techniques and may be key to future plasma wakefield-based free-electron lasers and high energy physics facilities, where large intrinsic chirps need to be removed.

Published
2019

6. The FLASHForward Facility at DESY

Author

Aschikhin, A., Behrens, C., Bohlen, S., Dale, J., Delbos, N., di Lucchio, L., Elsen, E., Erbe, J. -H., Felber, M., Foster, B., Goldberg, L., Grebenyuk, J., Gruse, J. -N., Hidding, B., Hu, Zhanghu, Karstensen, S., Knetsch, A., Kononenko, O., Libov, V., Ludwig, K., Maier, A. R., de la Ossa, A. Martinez, Mehrling, T., Palmer, C. A. J., Pannek, F., Schaper, L., Schlarb, H., Schmidt, B., Schreiber, S., Schwinkendorf, J. -P., Steel, H., Streeter, M., Tauscher, G., Wacker, V., Weichert, S., Wunderlich, S., Zemella, J., and Osterhoff, J.

Subjects
Physics - Accelerator Physics
Abstract

The FLASHForward project at DESY is a pioneering plasma-wakefield acceleration experiment that aims to produce, in a few centimetres of ionised hydrogen, beams with energy of order GeV that are of quality sufficient to be used in a free-electron laser. The plasma wave will be driven by high-current density electron beams from the FLASH linear accelerator and will explore both external and internal witness-beam injection techniques. The plasma is created by ionising a gas in a gas cell with a multi-TW laser system, which can also be used to provide optical diagnostics of the plasma and electron beams due to the <30 fs synchronisation between the laser and the driving electron beam. The operation parameters of the experiment are discussed, as well as the scientific program., Comment: 19 pages, 9 figures

Published
2015
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7. The FLASHForward facility at DESY

Author

Aschikhin, A, Behrens, C, Bohlen, S, Dale, J, Delbos, N, Di Lucchio, L, Elsen, E, Erbe, JH, Felber, M, Foster, B, Goldberg, L, Grebenyuk, J, Gruse, JN, Hidding, B, Hu, Z, Karstensen, S, Knetsch, A, Kononenko, O, Libov, V, Ludwig, K, Maier, AR, Martinez De La Ossa, A, Mehrling, T, Palmer, CAJ, Pannek, F, Schaper, L, Schlarb, H, Schmidt, B, Schreiber, S, Schwinkendorf, JP, Steel, H, Streeter, M, Tauscher, G, Wacker, V, Weichert, S, Wunderlich, S, Zemella, J, and Osterhoff, J

Subjects
Plasma, Wakefield, Acceleration, Beam line, Spectrometer, physics.acc-ph, Nuclear & Particles Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

The FLASHForward project at DESY is a pioneering plasma-wakefield acceleration experiment that aims to produce, in a few centimetres of ionised hydrogen, beams with energy of order GeV that are of quality sufficient to be used in a free-electron laser. The plasma is created by ionising a gas in a gas cell with a multi-TW laser system. The plasma wave will be driven by high-current-density electron beams from the FLASH linear accelerator. The laser system can also be used to provide optical diagnostics of the plasma and electron beams due to the

Published
2016

8. FLASHForward : plasma wakefield accelerator science for high-average-power applications

Author

D’Arcy, R., Aschikhin, A., Bohlen, S., Boyle, G., Brümmer, T., Chappell, J., Diederichs, S., Foster, B., Garland, M. J., Goldberg, L., Gonzalez, P., Karstensen, S., Knetsch, A., Kuang, P., Libov, V., Ludwig, K., de la Ossa, A. Martinez, Marutzky, F., Meisel, M., Mehrling, T. J., Niknejadi, P., Põder, K., Pourmoussavi, P., Quast, M., Röckemann, J. -H., Schaper, L., Schmidt, B., Schröder, S., Schwinkendorf, J. -P., Sheeran, B., Tauscher, G., Wesch, S., Wing, M., Winkler, P., Zeng, M., and Osterhoff, J.

Published
2019

9. Rationale, design and methods of the HEALTHY study behavior intervention component.

Author

Venditti, EM, Elliot, DL, Faith, MS, Firrell, LS, Giles, CM, Goldberg, L, Marcus, MD, Schneider, M, Solomon, S, Thompson, D, Yin, Z, and HEALTHY Study Group

Subjects
HEALTHY Study Group, Humans, Diabetes Mellitus, Type 2, Obesity, Risk Factors, Pilot Projects, Health Knowledge, Attitudes, Practice, Feeding Behavior, Health Behavior, Peer Group, Health Education, Research Design, Curriculum, Schools, Adolescent, Child, United States, Female, Male, Behavioral and Social Science, Basic Behavioral and Social Science, Prevention, Nutrition, Mind and Body, Clinical Research, Pediatric, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Metabolic and endocrine, Quality Education, middle schools, type 2 diabetes, prevention, peer influence, behavior modification, Medical and Health Sciences, Education, Endocrinology & Metabolism
Abstract

HEALTHY was a multi-center primary prevention trial designed to reduce risk factors for type 2 diabetes in adolescents. Seven centers each recruited six middle schools that were randomized to either intervention or control. The HEALTHY intervention integrated multiple components in nutrition, physical education, behavior change and communications and promotion. The conceptual rationale as well as the design and development of the behavior intervention component are described. Pilot study data informed the development of the behavior intervention component. Principles of social learning and health-related behavior change were incorporated. One element of the behavior intervention component was a sequence of peer-led, teacher-facilitated learning activities known as FLASH (Fun Learning Activities for Student Health). Five FLASH modules were implemented over five semesters of the HEALTHY study, with the first module delivered in the second semester of the sixth grade and the last module in the second semester of the eighth grade. Each module contained sessions that were designed to be delivered on a weekly basis to foster self-awareness, knowledge, decision-making skills and peer involvement for health behavior change. FLASH behavioral practice incorporated individual and group self-monitoring challenges for eating and activity. Another element of the behavior intervention component was the family outreach strategy for extending changes in physical activity and healthy eating beyond the school day and for supporting the student's lifestyle change choices. Family outreach strategies included the delivery of newsletters and supplemental packages with materials to promote healthy behavior in the home environment during school summer and winter holiday breaks. In conclusion, the HEALTHY behavior intervention component, when integrated with total school food and physical education environmental changes enhanced by communications and promotional campaigns, is a feasible and acceptable mechanism for delivering age-appropriate social learning for healthy eating and physical activity among an ethnically diverse group of middle school students across the United States.

Published
2009

10. The Complexity of Approximating the Complex-Valued Ising Model on Bounded Degree Graphs

Author

Galanis, A, Goldberg, L, and Herrera-Poyatos, A

Subjects
FOS: Computer and information sciences, Computer Science - Computational Complexity, General Mathematics, FOS: Mathematics, Mathematics - Combinatorics, G.2.1, G.2.2, Combinatorics (math.CO), F.2.2, Computational Complexity (cs.CC), 68R05
Abstract

We study the complexity of approximating the partition function $Z_{\mathrm{Ising}}(G; \beta)$ of the Ising model in terms of the relation between the edge interaction $\beta$ and a parameter $\Delta$ which is an upper bound on the maximum degree of the input graph $G$. Following recent trends in both statistical physics and algorithmic research, we allow the edge interaction $\beta$ to be any complex number. Many recent partition function results focus on complex parameters, both because of physical relevance and because of the key role of the complex case in delineating the tractability/intractability phase transition of the approximation problem. In this work we establish both new tractability results and new intractability results. Our tractability results show that $Z_{\mathrm{Ising}}(-; \beta)$ has an FPTAS when $\lvert \beta - 1 \rvert / \lvert \beta + 1 \rvert < \tan(\pi / (4 \Delta - 4))$. The core of the proof is showing that there are no inputs~$G$ that make the partition function $0$ when $\beta$ is in this range. Our result significantly extends the known zero-free region of the Ising model (and hence the known approximation results). Our intractability results show that it is $\mathrm{\#P}$-hard to multiplicatively approximate the norm and to additively approximate the argument of $Z_{\mathrm{Ising}}(-; \beta)$ when $\beta \in \mathbb{C}$ is an algebraic number such that $\beta \not \in \mathbb{R} \cup \{i,-i\}$ and $\lvert \beta - 1\rvert / \lvert \beta + 1 \rvert > 1 / \sqrt{\Delta - 1}$. These are the first results to show intractability of approximating $Z_{\mathrm{Ising}}(-, \beta)$ on bounded degree graphs with complex $\beta$. Moreover, we demonstrate situations in which zeros of the partition function imply hardness of approximation in the Ising model., Comment: 49 pages, 9 figures On last update: we fixed some typos and updated the references

Published
2022

13. The FLASHForward facility at DESY

Author

Aschikhin, A., Behrens, C., Bohlen, S., Dale, J., Delbos, N., di Lucchio, L., Elsen, E., Erbe, J.-H., Felber, M., Foster, B., Goldberg, L., Grebenyuk, J., Gruse, J.-N., Hidding, B., Hu, Zhanghu, Karstensen, S., Knetsch, A., Kononenko, O., Libov, V., Ludwig, K., Maier, A.R., Martinez de la Ossa, A., Mehrling, T., Palmer, C.A.J., Pannek, F., Schaper, L., Schlarb, H., Schmidt, B., Schreiber, S., Schwinkendorf, J.-P., Steel, H., Streeter, M., Tauscher, G., Wacker, V., Weichert, S., Wunderlich, S., Zemella, J., and Osterhoff, J.

Published
2016
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16. Parameterised and Fine-Grained Subgraph Counting, Modulo 2

Author

Goldberg, L and Roth, M

Subjects
parameterised complexity, fine-grained complexity, Theory of computation → Problems, reductions and completeness, Mathematics of computing → Discrete mathematics, modular counting, subgraph counting
Abstract

Given a class of graphs ℋ, the problem ⊕Sub(ℋ) is defined as follows. The input is a graph H ∈ ℋ together with an arbitrary graph G. The problem is to compute, modulo 2, the number of subgraphs of G that are isomorphic to H. The goal of this research is to determine for which classes ℋ the problem ⊕Sub(ℋ) is fixed-parameter tractable (FPT), i.e., solvable in time f(|H|)⋅|G|^O(1). Curticapean, Dell, and Husfeldt (ESA 2021) conjectured that ⊕Sub(ℋ) is FPT if and only if the class of allowed patterns ℋ is matching splittable, which means that for some fixed B, every H ∈ ℋ can be turned into a matching (a graph in which every vertex has degree at most 1) by removing at most B vertices. Assuming the randomised Exponential Time Hypothesis, we prove their conjecture for (I) all hereditary pattern classes ℋ, and (II) all tree pattern classes, i.e., all classes ℋ such that every H ∈ ℋ is a tree. We also establish almost tight fine-grained upper and lower bounds for the case of hereditary patterns (I)., LIPIcs, Vol. 261, 50th International Colloquium on Automata, Languages, and Programming (ICALP 2023), pages 68:1-68:17

Published
2023
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23. Approximately counting answers to conjunctive queries with disequalities and negations

Author

Focke, J, Goldberg, L, Roth, M, and Zivny, S

Subjects
FOS: Computer and information sciences, Computer Science - Computational Complexity, Computer Science - Databases, Discrete Mathematics (cs.DM), Databases (cs.DB), Computational Complexity (cs.CC), Computer Science - Discrete Mathematics
Abstract

We study the complexity of approximating the number of answers to a small query $\varphi$ in a large database $\mathcal{D}$. We establish an exhaustive classification into tractable and intractable cases if $\varphi$ is a conjunctive query with disequalities and negations: $\bullet$ If there is a constant bound on the arity of $\varphi$, and if the randomised Exponential Time Hypothesis (rETH) holds, then the problem has a fixed-parameter tractable approximation scheme (FPTRAS) if and only if the treewidth of $\varphi$ is bounded. $\bullet$ If the arity is unbounded and we allow disequalities only, then the problem has an FPTRAS if and only if the adaptive width of $\varphi$ (a width measure strictly more general than treewidth) is bounded; the lower bound relies on the rETH as well. Additionally we show that our results cannot be strengthened to achieve a fully polynomial randomised approximation scheme (FPRAS): We observe that, unless $\mathrm{NP} =\mathrm{RP}$, there is no FPRAS even if the treewidth (and the adaptive width) is $1$. However, if there are neither disequalities nor negations, we prove the existence of an FPRAS for queries of bounded fractional hypertreewidth, strictly generalising the recently established FPRAS for conjunctive queries with bounded hypertreewidth due to Arenas, Croquevielle, Jayaram and Riveros (STOC 2021)., Comment: An extended abstract of this work is accepted for publication at PODS22. 30 pages, 1 figure

Published
2022

26. The complexity of approximating the complex-valued Potts model

Author

Galanis, A, Goldberg, L, and Herrera-Poyatos, A

Subjects
FOS: Computer and information sciences, Discrete Mathematics (cs.DM), partition function, General Mathematics, G.2.1, G.2.2, Computational Complexity (cs.CC), Computer Science::Digital Libraries, Theoretical Computer Science, FOS: Mathematics, Potts model, Mathematics - Combinatorics, complex numbers, approximate counting, Theory of computation → Problems, reductions and completeness, Mathematics of computing → Discrete mathematics, F.2.2, 68R05, Tutte polynomial, Computational Mathematics, Computer Science - Computational Complexity, Computational Theory and Mathematics, Theory of computation → Randomness, geometry and discrete structures, Combinatorics (math.CO), Computer Science - Discrete Mathematics
Abstract

We study the complexity of approximating the partition function of the $q$-state Potts model and the closely related Tutte polynomial for complex values of the underlying parameters. Apart from the classical connections with quantum computing and phase transitions in statistical physics, recent work in approximate counting has shown that the behaviour in the complex plane, and more precisely the location of zeros, is strongly connected with the complexity of the approximation problem, even for positive real-valued parameters. Previous work in the complex plane by Goldberg and Guo focused on $q=2$, which corresponds to the case of the Ising model; for $q>2$, the behaviour in the complex plane is not as well understood and most work applies only to the real-valued Tutte plane. Our main result is a complete classification of the complexity of the approximation problems for all non-real values of the parameters, by establishing \#P-hardness results that apply even when restricted to planar graphs. Our techniques apply to all $q\geq 2$ and further complement/refine previous results both for the Ising model and the Tutte plane, answering in particular a question raised by Bordewich, Freedman, Lov��sz and Welsh in the context of quantum computations., 58 pages. Changes on version 2: minor changes

Published
2021

28. Fast sampling via spectral independence beyond bounded-degree graphs

Author

Bezakova, I, Galanis, A, Goldberg, L, and Stefankovic, D

Subjects
FOS: Computer and information sciences, Theory of computation → Graph algorithms analysis, Markov chains, Computer Science - Data Structures and Algorithms, Theory of computation → Random walks and Markov chains, Data Structures and Algorithms (cs.DS), Hard-core model, Random graphs
Abstract

Spectral independence is a recently-developed framework for obtaining sharp bounds on the convergence time of the classical Glauber dynamics. This new framework has yielded optimal O(n log n) sampling algorithms on bounded-degree graphs for a large class of problems throughout the so-called uniqueness regime, including, for example, the problems of sampling independent sets, matchings, and Ising-model configurations. Our main contribution is to relax the bounded-degree assumption that has so far been important in establishing and applying spectral independence. Previous methods for avoiding degree bounds rely on using L^p-norms to analyse contraction on graphs with bounded connective constant (Sinclair, Srivastava, Yin; FOCS'13). The non-linearity of L^p-norms is an obstacle to applying these results to bound spectral independence. Our solution is to capture the L^p-analysis recursively by amortising over the subtrees of the recurrence used to analyse contraction. Our method generalises previous analyses that applied only to bounded-degree graphs. As a main application of our techniques, we consider the random graph G(n,d/n), where the previously known algorithms run in time n^O(log d) or applied only to large d. We refine these algorithmic bounds significantly, and develop fast nearly linear algorithms based on Glauber dynamics that apply to all constant d, throughout the uniqueness regime., LIPIcs, Vol. 229, 49th International Colloquium on Automata, Languages, and Programming (ICALP 2022), pages 21:1-21:16

Published
2021

32. Persistent SARS-CoV-2 infection and increasing viral variants in children and young adults with impaired humoral immunity

Author

Maurice R.G. O'Gorman, Goldberg L, Jaclyn A. Biegel, Rebecca Yee, Alexander R. Judkins, Oliver F. Wirz, Benjamin A. Pinsky, Andrew Pekosz, Lishuang Shen, David Ruble, Pia S. Pannaraj, Jennifer H. Han, Deepa Bhojwani, ChunHong Huang, Thao T. Truong, Alex Ryutov, Utsav Pandey, Malaya K. Sahoo, Dennis T. Maglinte, Moiz Bootwalla, Maggie Li, Scott D. Boyd, Xiaowu Gai, Katharina Röltgen, Paibel Aguayo-Hiraldo, Dejerianne Ostrow, and Dien Bard J

Subjects
Infectivity, Immune system, business.industry, Viral culture, Viral evolution, Humoral immunity, Medicine, Infection control, business, Influenza research, Virology, Serology
Abstract

SummaryBackgroundThere is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and subsequent emergence of novel strains with the potential to evade immune responses.MethodsWe describe three patients with acute lymphoblastic leukemia who were persistently positive for SARS-CoV-2 by real-time polymerase chain reaction. Viral viability from longitudinally-collected specimens was assessed. Whole-genome sequencing and serological studies were performed to measure viral evolution and evidence of immune escape.FindingsWe found compelling evidence of ongoing replication and infectivity for up to 162 days from initial positive by subgenomic RNA, single-stranded RNA, and viral culture analysis. Our results reveal a broad spectrum of infectivity, host immune responses, and accumulation of mutations, some with the potential for immune escape.InterpretationOur results highlight the need to reassess infection control precautions in the management and care of immunocompromised patients. Routine surveillance of mutations and evaluation of their potential impact on viral transmission and immune escape should be considered.FundingThe work was partially funded by The Saban Research Institute at Children’s Hospital Los Angeles intramural support for COVID-19 Directed Research (X.G. and J.D.B.), the Johns Hopkins Center of Excellence in Influenza Research and Surveillance HHSN272201400007C (A.P.), NIH/NIAID R01AI127877 (S.D.B.), NIH/NIAID R01AI130398 (S.D.B.), NIH 1U54CA260517 (S.D.B.), an endowment to S.D.B. from the Crown Family Foundation, an Early Postdoc.Mobility Fellowship Stipend to O.F.W. from the Swiss National Science Foundation (SNSF), and a Coulter COVID-19 Rapid Response Award to S.D.B. L.G. is a SHARE Research Fellow in Pediatric Hematology-Oncology.

Published
2021

43. Baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF)

Author

McMurray, John J.V., Anand, Inder S., Diaz, Rafael, Maggioni, Aldo P., OʼConnor, Christopher, Pfeffer, Marc A., Solomon, Scott D., Tendera, Michal, van Veldhuisen, Dirk J., Albizem, Moetaz, Cheng, Sunfa, Scarlata, Debra, Swedberg, Karl, Young, James B., Amuchastegui, M., Belziti, C., Bluguermann, J., Caccavo, M., Cartasegna, L., Colque, R., Cuneo, C., Fernandez, A., Gabito, A., Goicochea, R., Gonzalez, M., Gorosito, V., Grinfeld, L., Hominal, M., Kevorkian, R., Litvak Bruno, M., Llanos, J., Mackinnon, I., Manuale, O., Marzetti, E., Nul, D., Perna, E., Riccitelli, M., Sanchez, A., Santos, D., Schygiel, P., Toblli, J., Vogel, D., Aggarwal, A., Amerena, J., De Looze, F., Fletcher, P., Hare, D., Ireland, M., Krum, H., Lattimore, J., Marwick, T., Sindone, A., Thompson, P., Waites, J., Altenberger, J., Ebner, C., Lenz, K., Pacher, R., Poelzl, G., Charlier, F., de Ceuninck, M., De Keulenaer, G., Dendale, P., Maréchal, P., Mullens, W., Thoeng, J., Vanderheyden, M., Vanhaecke, J., Weytjens, C., Wollaert, B., Albuquerque, D., Almeida, D., Aspe y Rosas, J., Bocchi, E., Bordignon, S., Clausell, N., Kaiser, S., Leaes, P., Martins Alves, S., Montera, M., Moura, L., Pereira de Castro, R., Rassi, S., Reis, A., Saraiva, J., Simões, M., Souza Neto, J., Teixeira, M., Benov, H., Chompalova, B., Donova, T., Georgiev, P., Gotchev, D., Goudev, A., Grigorov, M., Guenova, D., Hergeldjieva, V., Ivanov, D., Kostova, E., Manolova, A., Marchev, S., Nikolov, F., Popov, A., Raev, D., Tzekova, M., Czarnecki, W., Giannetti, N., Haddad, H., Heath, J., Huynh, T., Lepage, S., Liu, P., Lonn, E., Ma, P., Manyari, D., Moe, G., Parker, J., Pesant, Y., Rajda, M., Ricci, J., Roth, S., Sestier, F., Sluzar, V., Sussex, B., Vizel, S., Antezana, G., Bugueno, C., Castro, P., Conejeros, C., Manriquez, L., Martinez, D., Potthoff, S., Stockins, B., Vukasovic, J., Gregor, P., Herold, M., Jerabek, O., Jirmar, R., Kuchar, R., Linhart, A., Podzemska, B., Soucek, M., Spac, J., Spacek, R., Vodnansky, P., Bronnum-Schou, J., Clemmensen, K., Egstrup, K., Jensen, G., Kjoller-Hansen, L., Kober, L., Markenvard, J., Rokkedal, J., Skagen, K., Torp-Pedersen, C., Tuxen, C., Videbak, L., Laks, T., Vahula, V., Harjola, V., Kettunen, R., Kotila, M., Bauer, F., Cohen Solal, A., Coisne, D., Davy, J., De Groote, P., Dos Santos, P., Funck, F., Galinier, M., Gibelin, P., Isnard, R., Neuder, Y., Roul, G., Sabatier, R., Trochu, J., Anker, S., Denny, S., Dreykluft, T., Flesch, M., Genth-Zotz, S., Hambrecht, R., Hein, J., Jeserich, M., John, M., Kreider-Stempfle, H., Laufs, U., Muellerleile, K., Natour, M., Sandri, M., Schäufele, T., von Hodenberg, E., Weyland, K., Winkelmann, B., Tse, H., Yan, B., Barsi, B., Csikasz, J., Dezsi, C., Edes, I., Forster, T., Karpati, P., Kerekes, C., Kis, E., Kosa, I., Lupkovics, G., Nagy, A., Preda, I., Ronaszeki, A., Tomcsanyi, J., Zamolyi, K., Agarwal, D., Bahl, V., Bordoloi, A., Chockalingam, K., Chopda, M., Chopra, V., Dugal, J., Ghaisas, N., Ghosh, S., Grant, P., Hiremath, S., Iyengar, 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2013
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47. Assessing the cardiology community position on transradial intervention and the use of bivalirudin in patients with acute coronary syndrome undergoing invasive management: results of an EAPCI survey

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Adamo, Marianna, Byrne, Robert A., Baumbach, Andreas, Haude, Michael, Windecker, Stephan, Valgimigli, Marco, Aaroe, J., Abdeltawab, A. A., Accardi, R., Addad, F., Agostoni, P., Alajab, A., Alcázar, E., Alhabil, B., Altug Cakmak, H., Amico, F., Amoroso, G., Anderson, R., Andò, G., Andreou, A. Y., Antoniadis, D., Aquilina, M., Aramberry, L., Auer, J., Auffret, V., Ausiello, A., Austin, D., Avram, A., Ayman, E., Babunashvili, V., Bagur, R., Bakotic, Z., Balducelli, M., Ballesteros, S. M., Baptista, S., Baranauskas, A., Barbeau, G., Bax, M., Benchimol, C., Berroth, R., Biasco, L., Bilal, A., Binias, K., Blanco Mata, R., Boccuzzi, G., Bolognese, L., Boskovic, S., Bourboulis, N., Briguori, C., Bunc, M., Buysschaert, I., Calabro’, P., Campo, G., Candiello, A., Caprotta, U. F., Cardenas, M., Carrilho-Ferreira, P., Carrizo, S., Caruso, M., Cassar, A., Cernigliaro, C., Chacko, G., Chamie, D., Clapp, B., Coceani, M., Colangelo, S., Colombo, A., Comeglio, M., Connaughton, M., Conway, D., Cortese, B., Cosgrave, J., Costa, F., Couvoussis, E., Crimi, G., Crook, R., Cruz-Alvarado, J. E., Curello, S., D’Ascenzo, F., D’Urbano, M., Dana, A., De Backer, O., De Carlo, M., De Cesare, N., De Iaco, G., De La Torre, H. J. M., De Oliveira Netoj, B., Devlin, G. P., Di Lorenzo, E., Díaz, A., Dina, C., Dorsel, T. H., Eberli, F. R., Echeverría, R., Eftychiou, C., Elguindy, A., Ercilla, J., Ernst, A., Esposito, G., Ettori, F., Eufracino, Null, Ezquerra Aguilera, W., Falcone, C., Falu, R. M., Feres, F., Ferlini, M., Fernández, G., Fernández-Rodríguez, D., Fileti, L., Fischetti, D., Florescu, N., Formigli, D., Fouladvand, F., Franco, N., Fresco, C., Frigoli, E., Furmaniuk, J., Gabaldo, K., Galli, M., Galli, S., Garbo, R., Garducci, S., Garg, S., Gavrielatos, G., Gensch, J., Giacchi, G., Giunio, L., Giustino, G., Goldberg, L., Goldsmit, R., Gommeaux, A., González Godínez, H., Gosselin, G., Govorov, A., Grimfjard, P., Gross, E., Grosz, C., Guagliumi, G., Hadad, W., Hadadi, L., Hansen, P. R., Harb, S., Hatrick, R., Hayrapetyan, H. G., Hernández-Enríquez, M., Ho Heo, J., Horvath, I. G., Huan Loh, P., Ibrahim, A. M., Ierna, S., Ilic, I., Imperadore, F., Ionescu-Silva, E., Jacksch, R., James, S., Janiak, B., Jensen, S. E., Jeroen, S., Jugessur, R. K., Kala, P., Kambis, M., Kanakakis, J., Karamasis, G., Karchevsky, D., Karpovskiy, A., Kayaert, P., Kedev, S., Kemala, E., Ketteler, T., Khan, S. Q., Kharlamov, A., Kiernan, T., Kiviniem, T., Koltowski, L., Koskinas, K. C., Kouloumpinis, A., Kraaijeveld, A. O., Krizanic, F., Krötz, B., Kuczmik, W., Kukreja, N., Kuksa, D., Yav, K., Kyriakos, D., Labrunie, A., Laine, M., Lapin, O., Larosa, C., Latib, A., Lattuca, B., Lauer, B., Lefèvre, T., Legrand, V., Lehto, P., Leiva-Pons, J. L., Leone, A. M., Lev, G., Lim, R., Limbruno, U., Linares Vicente, J. A., Lindsay, S., Linnartz, C., Liso, A., Lluberas, R., Locuratolo, N., Lokshyn, S., Lunde, K., Lupi, A., Magnavacchi, P., Maia, F., Mainar, V., Mancone, M., Manolios, M. G., Mansour, S., Mariano, E., Marques, K., Martins, H., Mckenzie, D., Meco, S., Meemook, K., Mehmed, K., Melikyan, A., Mellwig, K. P., Mendiz, O. A., Merkulov, E., Mesquita, H. G., Mezzapelle, G., Miloradovic, V., Mohamed, S., Mohammed, B., Mohammed, F., Mohammed, K., Mohanad, A., Morawiec, B., More, R., Moreno-Martínez, F. L., Mrevlje, B., Muhammad, F., Näveri, H., Nazzaro, M. S., Neary, P., Negus, B. H., Nelson Durval, F. G., Nick, H., Nilva, E., Oldroyd, K. G., Olivares Asencio, C., Omerovic, E., Ortiz, M. A., Ota, H., Otasevic, P., Otieno, H. A., Paizis, I., Papp, E., Pasquetto, G., Patsourakos, N. G., Peels, J., Pelliccia, F., Pennacchi, M., Penzo, C., Perez, P., Perkan, A., Petrou, E., Phipathananunth, W., Pierri, A., Pinheiro, L. F., Pipa, J. L., Piva, T., Polad, J., Porto, I., Poveda, J., Predescu, L., Prog, R., Puri, R., Raco, D. L., Ramazan, O., Ramazzotti, V., Rao, S. V., Raungaard, B., Reczuch, K., Rekik, S., Rhouati, A., Rigattieri, S., Rodríguez-Olivares, R., Roik, M., Romagnoli, E., Román, A. J., Routledge, H., Rubartelli, P., Rubboli, A., Ruiz-García, J., Russo, F., Ruzsa, Z., Ryding, A., Saad, Aly, Sabate, M., Sabouret, P., Sadowski, M., Saia, F., Sanchez Perez, I., Santoro, G. M., Sarenac, D., Saririan, M., Sarma, J., Schuetz, T., Sciahbasi, A., Sebastian, M., Sebik, R., Sesana, M., Hur, Seung-Ho, Sganzerla, P., Shalva, R., Sharma, S., Sheiban, I., Shein, K. K., Shiekh, I. A., Sinha, M., Slhessarenko, J., Smith, D., Smyth, D. W., Sönmez, K., Sood, N., Sourgounis, A., Srdanovic, I., Stables, R. H., Stefanini, G. G., Stewart, J., Stoyanov, N., Suliman, A. A., Suryadevara, R., Suwannasom, P., Tange Veien, K., Tauchert, S., Tebet, M., Testa, L., Thury, A., Tilsted, H. H., Tiroch, K., Torres, A., Tosi, P., Traboulsi, M., Trani, C., Tresoldi, S., Tsigkas, G., Tueller, D., Turri, M., Udovichenko, A. E., Uretsky, B., Van Der Harst, P., Van Houwelingen, K. G., Vandoni, P., Vandormael, M., Varbella, F., Venkitachalam, C. G., Vercellino, M., Vidal-Perez, R., Vigna, C., Vignali, L., Vogt, F., Voudris, V., Vranckx, P., Vrolix, M., Vydt, T., Webster, M., Wijns, W., Woody, W., Wykrzykowska, J., Yazdani, S., Yildiz, A., Yurlevich, D., Zauith, R., Zekanovic, D., Zhao, M., Zimarino, M., Zingarelli, A., Abdelsamad, A. Y., Abo Shaera, E. S., Afshar, M. S., Agatiello, C., Aguiar, P., Ahmad, A. M., Akin, I., Alameda, M., Alegría-Barrero, E., Alejos, R., Alkhashab, K., Alkutshan, R. S. A., Almorraweh, A., Altnji, I., Alvarez Iorio, C., Anchidin, O., Angel, J., Antonopoulos, A., Apshilava, G., Arana, C., Ashikaga, T., Assomull, R., Atef, S. Z., Azmus, A. D., Azzalini, L., Azzouz, A., Baglioni, P., Bampas, G., Basil, M. P., Baumbach, A., Besh, D., Bhushan Sharm, A., Bien Hsien, H., Bihui, L., Bing-Chen, L., Biryukov, S., Blatt, A., Bocchi, E., Boghdady, A., Bonarjee, V. V. S., Bosnjak, I., Bravo Baptista, S., Brinckman, S. L., Buchter, B., Burzotta, F., Cacucci, M., Cagliyan, C. E., Calabrò, P., Cernetti, C., Chávez Mizraym, R., Choo, W. S., Choudhury, R., Cicco, N., Cisneros Clavijo, P., Çitaku, H., Collet, J. P., Consuegra-Sánchez, L., Conte, M., Corral, J. M., Damonte, A., Dangoisse, V., Dastani, M., Della Rosa, F., Deora, S., Devadathan, S., Dharma, S., Di Giorgio, A., Diez, J. L., Dinesha, B., Duplančić, D., El Behwashi, M. F., Elghawaby, H., Elshahawy, O., Eskola, M. J., Etman, A., Eun Gyu, L., Fabiano, L., Facta, A., Fan, Y., Fang-Yang, H., Farag, E., Fathi, Y., Fazeli, N., Federico, P., Fereidoun, M. Z., Fernandez-Nofrerias, E., Flensted Lassen, J., Flessas, D., Fouad, H., Franco-Pelaez, J. A., Fu, Q., Furtado, R., Gadepalli, R., Gallino, R., Gasparetto, V., Gentiletti, A., Gholoobi, A., Ghosh, A. K., Gkizas, S., Golchha, S. K., Goncharov, A., Gössl, M., Götberg, M., Greco, F., Grundeken, M. J., Gupta, D., Gupta, S., Guray, U., Hahalis, G., Hakim Vista, J., Hamid, M. A., Hammoudeh, A., Hasan, A. R. I., Hatsumura, F. E., Heintzen, M. P., Helal, T., Hetherington, S., Hewarathna, U. I., Hioki, H., Hissein, F., Ho-Ping, Y., Homs, S., Huber, K., Ibarra, F. M., Ielasi, A., Ipek, E., Jambunathan, R., Jamshidi, P., Jarrad, I., Javier, W., Jensen, J., Jimenez-Quevedo, P., Kalpak, O., Kan, J., Kanaan, T., Kao, D. H. M., Karamfiloff, K., Karegren, A., Karjalainen, P. P., Kasabov, R., Katsimagklis, G. D., Kaul, U., Khan, A., Kiemeneij, E., Kiviniemi, T., Kleiban, A., Komiyama, N., Konteva, M., Koshy, G., Krepsky, A. M., Kuljit, S., Kulkarni, P., Kumar, V., Kuznetsov, I., Lai, G., Lateef, M. A., Lawand, S., Le Hong, T., Lettieri, C., Levy, G., Lindvall, P., Maitra, A., Makowski, M., Mamas, M. A., Mandal, S. C., Mangalanandan, P., Marin, R., Mashhadi, M., Matsukage, T., Meier, B., Milosavljevic, B., Miro, S. S., Mitov, A., Moeriel, M., Moguel, R., Mohanty, A., Montalescot, G., Mörsdorf, W., Moscato, F., Muniz, A., Muraglia, S., Myć, J., Nada, A., Nair, P., Namazi, M. H., Naraghipour, F., Nguyen, Q. N., Nicosia, A., Nikas, D., Ober, M., Ocaranza-Sánchez, R., Olivecrona, G., Pahlajani, D., Pandey, B. P., Parma, A., Parma, R., Patsilinakos, S. P., Pattam, J., Peddi, S., Perez, P. R., Peruga, J. Z., Pescoller, F., Petrov, I., Piatti, L., Pico-Aracil, F., Pina, J., Piroth, Z., Popa, V., Pourbehi, M. R., Pradhan, A. K., Prida, X. E., Purohit, B. V., Pyun, W. B., Quang Hung, D., Rada, I., Rafizadeh, O., Rahman, M. A., Rai, L., Ramsewak, A., Ravindran, R., Rodriguez De Leiras, O. S., Rodríguez Esteban, M., Roque Figueira, H., Saket, A., Sakhov, O., Saktheeswaran, M. K., Salachas, A., Sallam, A., Sampaolesi, A., Samy, A., Sanchis, J., Santaera, O., Santarelli, A., Santharaj, W. S., Sarango, B., Satheesh, S., Schmitz, T., Schühlen, H., Seewoosagur, R., Segev, A., Seisembekov, V., Semitko, S., Sengottuvelu, G., Sepulveda Varela, P., Sethi, A., Sharma, A., Sharma, R. K., Shi, Hy., Şimşek, M. A., Siqueira, B., Skalidis, E., Slawin, J., Sorokhtey, L., Spaulding, C., Srinivas, B., Srinivasan, M., Stakos, D., Stefanini, G., Stojkovic, S., Tacoy, G., Tawade, M., Tiecco, F., Tondi, S., Torresani, E. M., Tousek, P., Tran, T., Trantalis, G., Triantafyllou, K., Trivedi, R., Trivisonno, A., Tsui, K. L., Türkoğlu, C., Tzung-Dau, W., Ueno, H., Urban, U., Uretsky, B. F., Uscumlic, A., Venugopal, V., Verney, R., Vilar, J. V., Villacorta, V. 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G., Vishwanath, R., Vlachojannis, G. J., Vlachojannis, M., Vlad, V., Von Birgelen, C., Vukcevic, V., Wahab, A., Waksman, R., Wei-Wen, L., Weisz, G., Whittaker, A., Yadav, A., Yokoi, Y., Zacharoulis, A., Zahran, M., Zamani, J., Ziakas, A., Zimmermann, J. P., and Cardiology

Subjects
Hirudin, Percutaneous, Antithrombin, medicine.medical_treatment, Psychological intervention, 030204 cardiovascular system & hematology, medical, 0302 clinical medicine, Peptide Fragment, Surveys and Questionnaires, Surveys and Questionnaire, Medicine, Bivalirudin, 030212 general & internal medicine, Societies, Medical, Transradial, Anticoagulant, Hirudins, Middle Aged, Recombinant Protein, Recombinant Proteins, Femoral Artery, Radial Artery, Cardiology, acute coronary syndrome, bivalirudin, transradial, adult, antithrombins, cardiology, femoral artery, hirudins, humans, middle aged, peptide fragments, percutaneous coronary intervention, recombinant proteins, societies, medical, surveys and questionnaires, attitude of health personnel, radial artery, Acute coronary syndrome, Cardiology and Cardiovascular Medicine, Human, medicine.drug, Adult, medicine.medical_specialty, Attitude of Health Personnel, medicine.drug_class, MEDLINE, Antithrombins, 03 medical and health sciences, societies, Percutaneous Coronary Intervention, Internal medicine, Humans, Acute Coronary Syndrome, Peptide Fragments, Management of acute coronary syndrome, business.industry, Percutaneous coronary intervention, medicine.disease, business
Abstract

AIMS Our aim was to report on a survey initiated by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) collecting the opinion of the cardiology community on the invasive management of acute coronary syndrome (ACS), before and after the MATRIX trial presentation at the American College of Cardiology (ACC) 2015 Scientific Sessions. METHODS AND RESULTS A web-based survey was distributed to all individuals registered on the EuroIntervention mailing list (n=15,200). A total of 572 and 763 physicians responded to the pre- and post-ACC survey, respectively. The radial approach emerged as the preferable access site for ACS patients undergoing invasive management with roughly every other responder interpreting the evidence for mortality benefit as definitive and calling for a guidelines upgrade to class I. The most frequently preferred anticoagulant in ACS patients remains unfractionated heparin (UFH), due to higher costs and greater perceived thrombotic risks associated with bivalirudin. However, more than a quarter of participants declared the use of bivalirudin would increase after MATRIX. CONCLUSIONS The MATRIX trial reinforced the evidence for a causal association between bleeding and mortality and triggered consensus on the superiority of the radial versus femoral approach. The belief that bivalirudin mitigates bleeding risk is common, but UFH still remains the preferred anticoagulant based on lower costs and thrombotic risks.

Published
2016

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