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464 results on '"Gold PW"'

1. Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles: presence of Lewis- and Fischer-like neurohormonal immune phenotypes in humans?

Author

ELENKOV IJ, KVETNANSKY R, HASHIRAMOTO A, BAKALOV VK, LINK AA, ZACHMAN K, CRANE M, JEZOVA D, ROVENSKY J, DIMITROV MA, GOLD PW, FLEISHER T, CHROUSOS GP, WILDER RL, J. I.M.M.U.N.O.L. AUG, BONINI, Sergio, Elenkov, Ij, Kvetnansky, R, Hashiramoto, A, Bakalov, Vk, Link, Aa, Zachman, K, Crane, M, Jezova, D, Rovensky, J, Dimitrov, Ma, Gold, Pw, Bonini, Sergio, Fleisher, T, Chrousos, Gp, Wilder, Rl, and Aug, J. I. M. M. U. N. O. L.

Published
2008

2. Rat hypothalamic corticotropin-releasing hormone secretion is stimulated by interleukin-1 in an eicosanoid-dependent manner

Author

Bernardini, Renato, Calogero, Aldo Eugenio, Luger, A, Gold, Pw, and Chrousos, Gp

Subjects
Male, endocrine system, medicine.medical_specialty, Corticotropin-Releasing Hormone/secretion, Corticotropin-Releasing Hormone, Arachidonic Acids/metabolism, Hypothalamus/drug effects, Indomethacin, Hypothalamus, Arachidonic Acids, Peptide hormone, Biology, Dinoprost, Dexamethasone, Dinoprostone, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Internal medicine, medicine, Animals, Masoprocol, Cyclooxygenase Inhibitors, Secretion, Lipoxygenase Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Arachidonic Acid, Rats, Inbred Strains, General Medicine, 5,8,11,14-Eicosatetraynoic Acid, Lipooxygenase Inhibitor, Rats, Nordihydroguaiaretic acid, Endocrinology, chemistry, Eicosanoid, biology.protein, Eicosanoids, Corticotropin-releasing hormone secretion, Arachidonic acid, Cyclooxygenase, hormones, hormone substitutes, and hormone antagonists, Interleukin-1
Abstract

We studied the effect of interleukin-1 alpha (IL-1) on corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami in vitro. We also assessed possible mediation of arachidonic acid metabolites on IL-1-stimulated CRH secretion, by preincubating hypothalami with the cyclooxygenase inhibitor indomethacin (INDO, 1 microM), the lipoxygenase and cyclooxygenase inhibitor eicosatetraynoic acid (ETYA, 10 microM), or the lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA, up to 30 microM). In additional experiments, prostaglandins (PG) E2 and F2 alpha were added to the cultures treated with INDO or ETYA. Finally, we investigated the effect of dexamethasone (DEX) on IL-1-stimulated CRH secretion. IL-1 stimulated immunoreactive CRH (iCRH) secretion by explanted hypothalami in a concentration-dependent fashion. Both INDO and ETYA inhibited IL-1-(10nM)-stimulated iCRH secretion, whereas NDGA did not have any effect. The addition of PGF2 alpha (10 nM) restored the secretion of iCRH inhibited by INDO. DEX treatment significantly inhibited IL-1-stimulated iCRH release. Our results suggest that the stimulatory effect of IL-1 on the hypothalamic CRH neuron is mediated by the cyclooxygenase metabolites of arachidonic acid, and, among others, by PGF2 alpha.

Published
1990
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3. Sleep deprivation effects on the activity of the hypothalamic-pituitary-adrenal and growth axes: potential clinical implications

Author

Vgontzas, AN Mastorakos, G Bixler, EO Kales, A Gold, PW and Chrousos, GP

Abstract

OBJECTIVES Although several studies have shown that sleep deprivation is associated with increased slow wave sleep during the recovery night, the effects of sleep deprivation on cortisol and growth hormone (GH) secretion the next day and recovery night have not been assessed systematically. We hypothesized that increased slow wave sleep postsleep deprivation is associated with decreased cortisol levels and that the enhanced GH secretion is driven by the decreased activity of the HPA axis. DESIGN AND SUBJECTS After four consecutive nights in the Sleep Laboratory, 10 healthy young men were totally deprived of sleep during the fifth night, and then allowed to sleep again on nights six and seven. Twenty-four hour blood sampling was performed serially every 30 minutes on the fourth day, immediately following the previous night of sleep and on the sixth day, immediately after sleep deprivation. MEASUREMENT Eight-hour sleep laboratory recording, including electroencephologram, electro-oculogram and electromyogram. plasma cortisol and GH levels using specific immunoassay techniques. RESULTS Mean plasma and time-integrated (AUC) cortisol levels were lower during the postdeprivation nighttime period than on the fourth night (P

Published
1999

27. Autoimmune thyroiditis in manic-depressive patients treated with lithium

Author

Skwerer R, Gupta Mk, Gold Pw, Gulledge Ad, Schumacher Op, Hahn K, Calabrese, Kotz M, and Krupp N

Subjects
Adult, Male, Thyroiditis, endocrine system, Bipolar Disorder, Adolescent, endocrine system diseases, Exacerbation, Lithium (medication), T-Lymphocytes, Thyroid Gland, Thyrotropin, Lithium, Autoimmune Diseases, Autoimmune thyroiditis, Hypothyroidism, Isoantibodies, Humans, Medicine, biology, business.industry, Thyroid, Antibody titer, Middle Aged, medicine.disease, Thyroxine, Psychiatry and Mental health, medicine.anatomical_structure, Acute Disease, Immunology, biology.protein, Female, Thyroid function, Antibody, business, medicine.drug
Abstract

To explore whether lithium-induced hypothyroidism is related to an exacerbation of underlying autoimmune processes such as thyroiditis, the authors comprehensively assessed thyroid function in 16 manic-depressive patients. Each of the three patients who showed detectable titers of thyroid microsomal antibodies before treatment manifested a marked increase in antibody titer from 4 to 12 months after lithium treatment was begun. Thus, lithium-induced thyroid dysfunction may not only involve direct effects on the thyroid itself but also involve exacerbation of an underlying indolent autoimmune thyroiditis, possibly by causing shifts in T lymphocyte subpopulations.

Published
1985
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