117 results on '"Gokan, T."'
Search Results
2. How the rise of teleworking will reshape labor markets and cities
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Gokan, T., Kichko, S., Matheson, J.A., and Thisse, J.-F.
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In recent years the land-rent gradient for the city of London has flattened by 17 percentage points. Further, teleworking has increased 24 percentage point for skilled workers, but much less for unskilled workers. To rationalize these stylized facts, we propose a model of the monocentric city with heterogeneous workers and teleworking. Skilled workers, working in final goods production, can telework while unskilled workers, working in either final goods or local services production, cannot. We show that increased teleworking flattens the land-rent gradient, and eventually skilled workers move from the city center to the city’s periphery, fundamentally changing the city structure. The increased teleworking has implications for unskilled workers who move from the local services sector into final goods, leading to greater wage inequality between skilled and unskilled workers. The model is extended to two cities which differ in productivity. Teleworking allows skilled workers of the more productive city to reside in the less productive city where housing is cheaper. This increases housing prices in the less productive city, relative to the more productive city, and has implications for unskilled workers in both cities. We provide empirical evidence from housing prices in England which is consistent with this result.
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- 2022
3. A newly developed three-dimensional profile scanner with nanometer spatial resolution
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Shinno, H., Yoshioka, H., Gokan, T., and Sawano, H.
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- 2010
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4. P4833Risk predictors of supraventricular tachycardia and bradycardia necessitating therapy in patients with unexplained syncope receiving implantable loop recorder
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Onuki, T, primary, Gokan, T, additional, Nakamura, Y, additional, Okada, N, additional, Chiba, Y, additional, Kawasaki, S, additional, Onishi, Y, additional, Munetsugu, Y, additional, Ito, H, additional, Shoji, M, additional, Watanabe, N, additional, Minoura, Y, additional, Adachi, T, additional, Kawamura, M, additional, and Kobayashi, Y, additional
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- 2018
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5. Cerebral CT angiography using a small volume of concentrated contrast material with a test injection method: optimal scan delay for quantitative and qualitative performance
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Takeyama, N, primary, Kuroki, K, additional, Hayashi, T, additional, Sai, S, additional, Okabe, N, additional, Kinebuchi, Y, additional, Hashimoto, T, additional, and Gokan, T, additional
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- 2012
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6. Comparison of different volumes of saline flush in the assessment of perivenous artefacts in the subclavian vein during cervical CT angiography
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Takeyama, N, primary, Ohgiya, Y, additional, Hayashi, T, additional, Takahashi, T, additional, Takasu, D, additional, Nakashima, J, additional, Kato, K, additional, Kinebuchi, Y, additional, Hashimoto, T, additional, and Gokan, T, additional
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- 2011
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7. Abstract No. 88: Balloon-Occluded retrograde transvenous obliteration for portosystemic encephalopathy in patients with liver cirrhosis
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Honda, M., primary, Sekiyama, K., additional, Baba, T., additional, Matsuura, K., additional, Seino, N., additional, and Gokan, T., additional
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- 2010
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8. 2108 Comparison FDG-PET/CT findings of head and neck cancer after preoperative radiotherapy with pathological findings
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Yokouchi, J., primary, Shinjo, H., additional, Takada, N., additional, Tomoda, T., additional, Nakamura, T., additional, Fuwa, N., additional, Gokan, T., additional, Sakuma, H., additional, Konno, A., additional, and Hamada, K., additional
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- 2009
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9. Comparison of 40 and 60 milliliters of contrast in assessment of the carotid artery by computed tomography angiography
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Takeyama, N., primary, Ohgiya, Y., additional, Itokawa, H., additional, Takahashi, Y., additional, Obuchi, M., additional, Shinjyo, H., additional, Matsui, S., additional, Hayashi, T., additional, Kato, K., additional, Fujimoto, T., additional, Kinebuchi, Y., additional, Kitahara, T., additional, and Gokan, T., additional
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- 2008
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10. Abstract No. 235: Angio-CT Image-Guided Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma in the Caudate Lobe
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Honda, M., primary, Hashimoto, T., additional, Seino, N., additional, and Gokan, T., additional
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- 2008
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11. Commonly encountered adrenal pseudotumours on CT
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Gokan, T, primary, Ohgiya, Y, additional, Nobusawa, H, additional, and Munechika, H, additional
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- 2005
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12. Ultrasonography-guided percutaneous transhepatic portacaval shunt creation.
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Honda M, Baba T, Hashimoto T, Seino N, Gokan T, Honda, Minoru, Baba, Toshiyuki, Hashimoto, Toshi, Seino, Noritaka, and Gokan, Takehiko
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We successfully created a percutaneous transhepatic portacaval shunt under ultrasonography (US) guidance in a 46-year-old man with refractory ascites. The shunt was created to salvage an attempt to create a transjugular intrahepatic portosystemic shunt (TIPS) that failed because of the elevated level of portal vein bifurcation due to alcoholic liver cirrhosis. Under US guidance, we simultaneously punctured the right branch of the portal vein and the inferior vena cava (IVC) using a two-step biliary drainage set. An Amplatz gooseneck snare was introduced transjugularly to retrieve the percutaneously inserted guidewire. The intrahepatic tract between the portal vein and the IVC was dilated using a balloon catheter, and a stent was placed in the tract. The patient showed complete resolution of ascites at discharge. We assume that our method is an alternative method for TIPS creation in patients with inadequate anatomical relations between the portal vein branches and the hepatic veins. This approach is thought to be feasible for patients with occluded or small hepatic veins. [ABSTRACT FROM AUTHOR]
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- 2010
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13. Papillary renal cell carcinoma showing high signal intensity on T2-weighted magnetic resonance images: radiological-pathological correlation.
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Kawahara M, Ohgiya Y, Gokan T, Yamochi T, Fukagai T, Ogawa Y, Kawahara, Masaaki, Ohgiya, Yoshimitu, Gokan, Takehiko, Yamochi, Toshiko, Fukagai, Takashi, and Ogawa, Yoshio
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Papillary renal cell carcinoma (PRCC) is the second most common class of renal cell carcinoma. PRCCs have typically been reported to demonstrate homogeneous, low-intensity signals in T2-weighted magnetic resonance imaging (MRI) scans and rarely high-intensity signals. We reported two cases of PRCC with high signal intensity on T2-weighted images. These two cases were accompanied by a small amount of hemosiderin deposition and intense edema in the tumor. [ABSTRACT FROM AUTHOR]
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- 2009
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14. Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells.
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Hicks, David G., O'Keefe, Regis J., Rosier, Randy N., Sickel, Joshua Z., Judkins, Alexander R., Gokan, Takehiko, Totterman, Saara M. S., Fultz, Patrick J, Meyers, Steven P., Rubens, Deborah J., Hicks, D G, Gokan, T, O'Keefe, R J, Totterman, S M, Fultz, P J, Judkins, A R, Meyers, S P, Rubens, D J, Sickel, J Z, and Rosier, R N
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- 1995
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15. Images in cardiovascular medicine. Pulmonary vein obstruction after catheter ablation following atrial fibrillation.
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Akutsu Y, Kaneko K, Kodama Y, Li HL, Suyama J, Shinozuka A, Gokan T, Hamazaki Y, Tanno K, Kobayashi Y, Akutsu, Yasushi, Kaneko, Kyouichi, Kodama, Yusuke, Li, Hui-Ling, Suyama, Jumpei, Shinozuka, Akira, Gokan, Takehiko, Hamazaki, Yuji, Tanno, Kaoru, and Kobayashi, Youichi
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- 2011
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16. Equivalent edge currents of physical optics components for flat plate.
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Ando, M., Murasaki, T., and Gokan, T.
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- 1991
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17. A rare case of adenosine-sensitive atrial tachycardia originating at the mitral annulus's anterior septum.
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Arai S, Asano T, Nakamura Y, Gokan T, Onishi Y, and Shinke T
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Competing Interests: The authors have no financial or personal relationships to disclose.
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- 2024
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18. Natto extract inhibits infection caused by the Aujeszky's disease virus in mice.
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Kobayashi J, Wen R, Nishikawa T, Nunomura Y, Suzuki T, Sejima Y, Gokan T, Furukawa M, Yokota T, Osawa N, Sato Y, Nibu Y, Mizutani T, and Oba M
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- Swine, Animals, Mice, Antibodies, Viral, Herpesvirus 1, Suid, Soy Foods, Swine Diseases, Pseudorabies prevention & control
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Aujeszky's disease virus (ADV), also known as Suid alphaherpesvirus 1, which mainly infects swine, causes life-threatening neurological disorders. This disease is a serious global risk factor for economic losses in the swine industry. The development of new anti-ADV drugs is highly anticipated and required. Natto, a traditional Japanese fermented food made from soybeans, is a well-known health food. In our previous study, we confirmed that natto has the potential to inhibit viral infections by severe acute respiratory syndrome coronavirus 2 and bovine alphaherpesvirus 1 through their putative serine protease(s). In this study, we found that an agent(s) in natto functionally impaired ADV infection in cell culture assays. In addition, ADV treated with natto extract lost viral infectivity in the mice. We conducted an HPLC gel-filtration analysis of natto extract and molecular weight markers and confirmed that Fraction No. 10 had ADV-inactivating ability. Furthermore, the antiviral activity of Fraction No. 10 was inhibited by the serine protease inhibitor 4-(2-Aminoethyl) benzene sulfonyl fluoride hydrochloride (AEBSF). These results also suggest that Fraction No. 10, adjacent to the 12.5 kDa peak of the marker in natto extract, may inactivate ADV by proteolysis. Our findings provide new avenues of research for the prevention of Aujeszky's disease., (© 2023 The Societies and John Wiley & Sons Australia, Ltd.)
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- 2023
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19. Fermented soybean foods (natto) ameliorate age-related cognitive decline by hippocampal TAAR1-mediated activation of the CaMKII/CREB/BDNF signaling pathway in senescence-accelerated mouse prone 8 (SAMP8).
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Zheng Y, Yasuda M, Yamao M, Gokan T, Sejima Y, Nishikawa T, and Katayama S
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- Mice, Animals, Calcium-Calmodulin-Dependent Protein Kinase Type 2 metabolism, Calcium-Calmodulin-Dependent Protein Kinase Type 2 pharmacology, Brain-Derived Neurotrophic Factor metabolism, Cyclic AMP Response Element-Binding Protein genetics, Cyclic AMP Response Element-Binding Protein metabolism, Glycine max metabolism, Aging, Signal Transduction, Hippocampus metabolism, Soy Foods, Cognitive Dysfunction drug therapy, Cognitive Dysfunction metabolism
- Abstract
Natto is a traditional fermented soybean-based food that has been an integral part of Japanese cuisine for several centuries. Although there have been extensive studies on the cognitive benefits of soybeans, only limited studies have examined the effects of natto on cognitive function. This study investigated the potential cognitive benefits of natto in senescence-accelerated mouse-prone 8 (SAMP8) mice. After 12 weeks of oral administering natto fermented for 18 h, the spatial learning and memory performance were improved compared with those in SAMP8 control mice. Furthermore, activation of the brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element-binding protein (CREB) signaling and N -methyl-D-aspartate receptor (NMDAR)-calcium/calmodulin-dependent protein kinase II (CaMKII) cascade was observed in the hippocampus of SAMP8 mice that were fed natto. Additionally, natto administration upregulated trace amine-associated receptor 1 (TAAR1) as a modulator of NMDAR. These findings suggest that natto ameliorates cognitive decline by activating the TAAR1-mediated CaMKII/CREB/BDNF signaling pathway in the hippocampus of SAMP8 mice.
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- 2023
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20. Esophageal thermal lesions in radiofrequency ablation for atrial fibrillation: A prospective comparative study of thermal sensors.
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Arai S, Watanabe N, Sugiyama H, Gokan T, Yoshikawa K, Nakamura Y, Inokuchi K, Chiba Y, Onishi Y, Onuki T, Asano T, Kobayashi Y, and Shinke T
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- Body Temperature, Esophagus, Humans, Prospective Studies, Atrial Fibrillation surgery, Catheter Ablation
- Abstract
Background: Esophageal thermal lesion (ETL) is a complication of radiofrequency ablation for atrial fibrillation (RFAF). To prospectively compare the incidence of ETL, we used two linear, five- and three-sensor esophageal thermal monitoring catheters (ETMC5 and ETMC3). We also evaluated the predictors of ETL., Methods: Patients receiving their first RFAF (n = 106) were randomized into two groups, ETMC5 (n = 52) and ETMC3 (n = 54). Ablation was followed by esophagogastroduodenoscopy within 3 days., Results: Esophageal thermal lesion was detected in 7/106 (6.6%) patients (ETMC5: 3/52 [5.8%] vs. ETMC3: 4/54 [7.4%]; p = 1.0). The maximum temperature and number of measurements > 39.0°C did not differ between the groups (ETMC5: 40.5°C and 5.4 vs. ETMC3: 40.6°C and 4.9; p = .83 and p = .58, respectively). In ETMC5 group, the catheter had to be moved significantly less often (0.12 vs. 0.42; p = .0014) and fluoroscopy time was significantly shorter (79.2 min vs. 101.7 min; p = .0038) compared with ECMC3 group. The total number of ablations in ETMC5 group was significantly greater (50.2 vs. 37.7; p = .030) and ablation time was significantly longer (52.1 min vs. 40.1 min; p = .0039). Only body mass index (BMI) was significantly different between patients with and without ETL (21.4 ± 2.5 vs. 24.3 ± 3.4; p = .022)., Conclusions: The incidence of ETL was comparable between ETMC5 and ETMC3 groups; however, fluoroscopy time, total ablation time, and total number of ablations differed significantly. Lower BMI may increase the risk of developing ETL., (© 2022 Wiley Periodicals LLC.)
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- 2022
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21. Relationship between device-detected subclinical atrial fibrillation and heart failure in patients with cardiac resynchronization therapy defibrillator.
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Arai S, Kawamura M, Gokan T, Yoshikawa K, Ogawa K, Ochi A, Munetsugu Y, Ito H, and Shinke T
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- Aged, Atrial Fibrillation complications, Atrial Fibrillation therapy, Female, Follow-Up Studies, Heart Failure etiology, Heart Failure physiopathology, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Treatment Outcome, Atrial Fibrillation diagnosis, Cardiac Resynchronization Therapy methods, Defibrillators, Implantable, Heart Failure diagnosis, Ventricular Function, Left physiology
- Abstract
Background: Atrial fibrillation (AF) is a leading preventable cause of heart failure (HF) for which early detection and treatment is critical. Subclinical-AF is likely to go untreated in the routine care of patients with cardiac resynchronization therapy defibrillator (CRT-D)., Hypothesis: The hypothesis of our study is that subclinical-AF is associated with HF hospitalization and increasing an inappropriate therapy., Methods: We investigated 153 patients with an ejection fraction less than 35%. We divided into three groups, subclinical-AF (n = 30), clinical-AF (n = 45) and no-AF (n = 78). We compared the baseline characteristics, HF hospitalization, and device therapy among three groups. The follow-up period was 50 months after classification of the groups., Results: The average age was 66 ± 15 years and the average ejection fraction was 26 ± 8%. Inappropriate therapy and biventricular pacing were significantly different between subclinical-AF and other groups (inappropriate therapy: subclinical-AF 13% vs clinical-AF 8.9% vs no-AF 7.7%: P = .04, biventricular pacing: subclinical-AF 81% vs clinical-AF 85% vs no-AF 94%, P = .001). Using Kaplan-Meier method, subclinical-AF group had a significantly higher HF hospitalization rate as compared with other groups. (subclinical-AF 70% vs clinical-AF 49% vs no-AF 38%, log-rank: P = .03). In multivariable analysis, subclinical-AF was a predictor of HF hospitalization., Conclusions: Subclinical-AF after CRT-D implantation was associated with a significantly increased risk of HF hospitalization. The loss of the biventricular pacing and increasing an inappropriate therapy might affect the risk of HF hospitalization., (© 2020 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.)
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- 2020
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22. Three cases of histologically proven hepatic epithelioid hemangioendothelioma evaluated using a second-generation microbubble contrast medium in ultrasonography: case reports.
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Arai J, Shimozuma Y, Otoyama Y, Sugiura I, Nakajima Y, Hayashi E, Kajiwara A, Omori R, Uozumi S, Miyashita M, Uchikoshi M, Doi H, Sakaki M, Wang T, Eguchi J, Ito T, Kurihara T, Munechika J, Gokan T, Saito K, Miura S, Tate G, Takimoto M, and Yoshida H
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- Adult, Aged, 80 and over, Contrast Media pharmacology, Diagnosis, Differential, Female, Humans, Image Enhancement methods, Male, Perfusion Imaging, Ferric Compounds pharmacology, Hemangioendothelioma, Epithelioid diagnosis, Hemangioendothelioma, Epithelioid pathology, Iron pharmacology, Liver Neoplasms diagnosis, Liver Neoplasms pathology, Oxides pharmacology, Ultrasonography methods
- Abstract
Background: Hepatic epithelioid hemangioendothelioma (HEH) is rare; it is reported in < 1 person in 1,000,000 individuals. For accurate diagnosis, information regarding multiple graphic modalities in HEH is required. However, there is very little information concerning Sonazoid® contrast enhanced ultrasonography (CEUS) in HEH., Case Presentation: The present report describes the histologically proven three HEH cases evaluated using Sonazoid® CEUS. Case 1 was a 33-year-old female patient with no relevant past medical history, who experienced right upper quadrant pain. Conventional abdominal US revealed multiple low echoic liver nodules with vague borderlines. In CEUS, the vascularity of the nodules was similar to that seen in the neighboring normal liver. Later in the portal venous and late phases (PVLP) and post vascular phase, washout of Sonazoid® was detected in the nodules. Case 2 was a 93-year-old female patient with a previous medical history including operations for breast cancer and ovary cancer in her 50's. Conventional abdominal US revealed multiple low echoic nodules, some of which contained cystic lesions. In the early vascular phase of CEUS, nodules excluding the central anechoic regions were enhanced from peripheral sites. Although the enhancement inside the nodules persisted in both the PVLP and post vascular phase, anechoic areas in the center of some nodules were not enhanced at all. Case 3 was a 39-year-old male patient presented with right upper-quadrant pain, without any relevant past medical history. Conventional abdominal US revealed multiple low echoic liver nodules. In the early vascular phase of CEUS, nodules were gradually enhanced from the peripheral sites as ringed enhancement. Sonazoid®was washed out from the nodules in the PVLP and post vascular phase., Conclusions: The most important feature was peripheral enhancement in the early vascular phase. In case 2, the enhancement of the parenchyma of liver nodules persisted even in the PVLP; indicating the lower degree of malignant potential than others. Actually, the tumors did not extend without any treatment in case 2. Since case 2 is the first case report of HEH with cystic lesions, in patients with liver nodules including cystic lesions, HEH is a potential diagnosis.
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- 2019
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23. Idiopathic basal crux ventricular arrhythmias with left bundle branch block and superior axis: A comparison with inferior-septal valvular arrhythmias.
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Kawamura M, Arai S, Gokan T, Yoshikawa K, Ogawa K, Ochi A, Chiba Y, Onishi Y, Munetsugu Y, Ito H, Onuki T, Kobayashi Y, and Shinke T
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- Adult, Aged, Bundle-Branch Block physiopathology, Catheter Ablation, Coronary Sinus surgery, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Recurrence, Stroke Volume, Tachycardia, Ventricular physiopathology, Tachycardia, Ventricular surgery, Treatment Outcome, Ventricular Function, Left, Action Potentials, Bundle-Branch Block diagnosis, Coronary Sinus physiopathology, Electrocardiography, Electrophysiologic Techniques, Cardiac, Heart Rate, Tachycardia, Ventricular diagnosis
- Abstract
Introduction: Left bundle branch block (LBBB) with superior axis is common in patients with idiopathic-ventricular arrhythmia (VA) originating from the tricuspid annulus (TA) and rarely from the cardiac basal crux and mitral annulus (MA). We described the electrocardiography and electrophysiological findings of idiopathic-VA presenting with LBBB and superior axis., Methods and Results: We described 42 idiopathic-VA patients who had an LBBB and superior axis; 15 basal crux-VA, 17 TA-VA, and 10 MA-VA. No patient had a structural heart disease. Among patients with idiopathic-VA referred for ablation, we investigated the electrocardiogram and clinical characteristics of basal crux-VA as compared with other LBBB and superior axis-VA. The left ventricular ejection fraction with MA-VA was significantly lower in comparison with basal crux-VA (P = .01). All patients had a positive R wave in lead I and aVL. The maximum deflection index with basal crux-VA was significantly higher in comparison with TA-VA or MA-VA (P = .01). Patients with basal crux-VA presented with QS wave in lead II more frequently as compared with TA-VA or MA-VA (P = .001). All MA-VA patients had Rs wave in V6, and basal crux-VA, and TA-VA patients had a monophasic R wave or Rs wave in V6. Basal crux-VA patients underwent ablation in the middle cardiac vein (MCV) or coronary sinus (success rate: 94%, recurrence rate: 6%)., Conclusions: We could distinguish basal crux-VA, TA-VA, and MA-VA, using a combination of clinical and electrocardiographic findings. These findings might be useful for counseling patients about an ablation strategy. Ablation via the MCV is effective for eliminating basal crux-VA., (© 2019 Wiley Periodicals, Inc.)
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- 2019
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24. The clinical impact of MRI screening for BRCA mutation carriers: the first report in Japan.
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Murakami W, Tozaki M, Nakamura S, Ide Y, Inuzuka M, Hirota Y, Murakami K, Takahama N, Ohgiya Y, and Gokan T
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- Adult, Aged, Biopsy, Breast Neoplasms pathology, Carcinoma, Ductal, Breast pathology, Female, Follow-Up Studies, Humans, Japan, Mammography, Mass Screening methods, Middle Aged, Public Health Surveillance methods, Retrospective Studies, Young Adult, Breast Neoplasms diagnostic imaging, Breast Neoplasms genetics, Carcinoma, Ductal, Breast diagnostic imaging, Carcinoma, Ductal, Breast genetics, Genes, BRCA1, Genes, BRCA2, Magnetic Resonance Imaging, Mutation
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Background: There is no consensus on the appropriate surveillance for high-risk women with breast cancer in Japan. We investigated their imaging features and pathological characteristics to build a proper surveillance system for asymptomatic high-risk individuals in the future., Methods: We retrospectively reviewed 93 female (median age 43 years) BRCA1 and BRCA2 mutation carriers from our institutional clinical database from 2011 to 2017. The study population was composed of 112 breast cancers. Mammography and MRI were reviewed by examiners blinded to patients' clinical history. Final surgical or biopsy histopathology served as the reference standard in all the patients., Results: Fifty-nine breast cancers met selection criteria; of these, 30 were BRCA1-associated tumors, and 29 were BRCA2-associated tumors. Invasive ductal carcinoma was the most prevalent type in both BRCA1 and BRCA2. There were statistically significant differences in phenotype, nuclear grade, and Ki-67 labeling index between BRCA1 and BRCA2 mutation carriers. Additionally, imaging findings on mammography and MRI were statistically different. Tumors in BRCA2 carriers demonstrated mammographic calcifications more frequently, while those in BRCA1 carriers demonstrated a mass or architectural distortion (P < 0.001). Enhancement pattern on MRI also significantly differed between the two subgroups (P = 0.006). The size of MRI-detected lesions was statistically smaller than the size of those detected by other modalities (P = 0.004)., Conclusions: The imaging and histological characteristics of BRCA1/2 mutation carriers were consistent with other countries' studies. MRI-detected lesions were significantly smaller than lesions detected by non-MRI modality. All lesions in BRCA1 mutation carriers could be detected by MRI.
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- 2019
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25. J-Wave Elevation in the Inferior Leads Predicts Lethal Ventricular Arrhythmia Initiated by Premature Ventricular Contractions With Right Bundle Branch Block and Superior Axis.
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Munetsugu Y, Kawamura M, Gokan T, Ogawa K, Nakamura Y, Ochi A, Inokuchi K, Ito H, Onuki T, Kobayashi Y, and Shinke T
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- Action Potentials, Adolescent, Adult, Aged, Bundle-Branch Block complications, Bundle-Branch Block mortality, Bundle-Branch Block surgery, Catheter Ablation, Cause of Death, Female, Heart Rate, Humans, Male, Middle Aged, Predictive Value of Tests, Recurrence, Retrospective Studies, Risk Factors, Tachycardia, Ventricular diagnosis, Tachycardia, Ventricular mortality, Tachycardia, Ventricular prevention & control, Time Factors, Treatment Outcome, Ventricular Fibrillation diagnosis, Ventricular Fibrillation mortality, Ventricular Fibrillation prevention & control, Ventricular Premature Complexes complications, Ventricular Premature Complexes mortality, Ventricular Premature Complexes surgery, Young Adult, Bundle-Branch Block diagnosis, Electrocardiography, Tachycardia, Ventricular etiology, Ventricular Fibrillation etiology, Ventricular Premature Complexes diagnosis
- Abstract
Background: Lethal ventricular arrhythmia (VA) can be initiated by idiopathic premature ventricular contractions (PVCs) originating from the left ventricular (LV) inferior wall. Furthermore, J-wave elevation in the inferior leads on ECG is sometimes associated with lethal VA. However, the relationship between these PVCs and J-wave elevation in patients with lethal VA is unclear, so we investigated it in the present study.Methods and Results:We studied 32 consecutive patients who underwent radiofrequency (RF) ablation of idiopathic PVCs with right bundle branch block (RBBB) and superior axis. Thee PVCs were originating from the inferior wall of the LV. Lethal VA was defined as ventricular fibrillation (VF) or ventricular tachycardia (VT) with loss of consciousness (LOC). Among 32 patients, 3 had VF and 2 had VT with LOC. Other 27 had non-lethal VA. Baseline clinical characteristics were not significantly difference between lethal and non-lethal VA. The ratio of J-wave elevation in lethal VA was significantly higher as compared with non-lethal VA (100% vs. 11.1%, P<0.0001). Furthermore, no patients with J-wave elevation in the inferior leads had recurrence of lethal VA after RF ablation of the PVCs., Conclusions: We speculate that J-wave elevation in the inferior leads might be a predictor of lethal VA initiated by PVCs with RBBB and superior axis. RF ablation of these PVCs was a useful method of treating lethal VA.
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- 2019
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26. Association left ventricular lead and ventricular arrhythmias after upgrade to cardiac resynchronization therapy in patients with implantable cardioverter defibrillators.
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Kawamura M, Arai S, Yoshikawa K, Gokan T, Ogawa K, Ochi A, Onishi Y, Munetsugu Y, Ito H, Onuki T, Kobayashi Y, and Shinke T
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- Echocardiography, Electrocardiography, Female, Follow-Up Studies, Heart Ventricles diagnostic imaging, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Tachycardia, Ventricular diagnosis, Tachycardia, Ventricular physiopathology, Time Factors, Cardiac Resynchronization Therapy methods, Defibrillators, Implantable, Heart Rate physiology, Heart Ventricles physiopathology, Tachycardia, Ventricular therapy
- Abstract
Background: There are some controversial reports related to the pro-arrhythmic or anti-arrhythmic potential of cardiac resynchronization therapy (CRT) and little is known about the relationship between ventricular arrhythmia (VA) and left ventricular (LV)-lead threshold., Hypothesis: Upgrade CRT is anti-arrhythmic effect of VA with implantable cardioverter-defibrillator (ICD) patients and has a relationship with the incident of VA and LV-lead threshold., Methods: Among 384 patients with the implantation of CRT-defibrillator (CRT-D), 102 patients underwent an upgrade from ICD to CRT-D. We divided patients into three groups; anti-arrhythmic effect after upgrade (n = 22), pro-arrhythmic effect (n = 14), and unchanging-VA events (n = 66). The VA event was determined by device reports. We described the electrocardiography parameters, LV-lead characteristics, and clinical outcomes., Results: Before upgrade, the numbers of VA were 305 episodes and the numbers of ICD therapy were 157 episodes. While after upgrade, the numbers of VA were 193 episodes and the number of ICD therapy were 74 episodes. Ventricular tachycardia cycle length (VT-CL) after upgrade was significantly slower as compared to those with before upgrade. Pro-arrhythmic group was significantly higher with delta LV-lead threshold (after 1 month-baseline) as compared to those with anti-arrhythmic group (0.74 vs -0.21 V). Furthermore, pro-arrhythmic group was significantly bigger with delta VT-CL (after 3 months-before 3 months) as compared to those with anti-arrhythmic group (P = .03)., Conclusions: We described upgrade-CRT was associated with reduction of VA, ICD therapies and VT-CL. While 14 patients had a pro-arrhythmic effect and LV lead threshold might be associated with VA-incidents., (© 2019 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.)
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- 2019
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27. Intracardiac Thrombosis and Heart Failure in a Patient with Hepatocellular Carcinoma and Cardiac Amyloidosis and an Implanted Cardiac Resynchronization Therapy Device.
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Akutsu Y, Kawamura M, Tanisawa H, Nomura K, Gokan T, Sekimoto T, Kaneko K, Kodama Y, Ohgiya Y, Matsuyama T, Gokan T, and Shinke T
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- Aged, Amyloidosis surgery, Cardiac Resynchronization Therapy Devices, Echocardiography, Female, Heart Diseases surgery, Heart Failure surgery, Humans, Risk Factors, Thrombophilia, Thrombosis surgery, Tomography, X-Ray Computed, Amyloidosis complications, Carcinoma, Hepatocellular complications, Heart Diseases complications, Heart Failure complications, Liver Neoplasms complications, Thrombosis complications
- Abstract
BACKGROUND Intracardiac thrombosis has been known to be associated with not only hepatocellular carcinoma but also with amyloidosis and use of a cardiac implantable electronic device. We report a case of a continuous tumor thrombus with hepatocellular carcinoma from the portal vein and hepatic vein to the right atrium via the inferior vena cava in a patient with a cardiac amyloidosis and an implanted cardiac resynchronization therapy (CRT) device. CASE REPORT A 68-year-old female first admitted to our hospital because of heart failure with an AL type primary cardiac amyloidosis. After 3 years, she underwent an implantation of a CRT device for biventricular pacing following repeated episodes of heart failure and low left ventricular ejection fraction of 34% with NYHA class III. Again, she presented with symptoms of heart failure and cardiomegaly on chest x-ray at 7 years after the CRT device implantation. The echocardiography showed a huge echogenic mass occupying the right atrium, and 64 multi-detector computed tomography showed a lobulated heterogeneously enhancing mass of hepatocellular carcinoma in the right upper lobe of her liver and a continuous tumor thrombus from the portal vein and hepatic vein to the right atrium via the inferior vena cava. CONCLUSIONS Intracardiac thrombosis and heart failure occurred in a patient with hepatocellular carcinoma and cardiac amyloidosis, who had an implanted CRT device, which resulted not only in hypercoagulability by the hepatocellular carcinoma itself and the accumulation of various risk factors, but also the progression of myocardial damage with the development of amyloidosis.
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- 2019
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28. Evaluation of hepatocellular carcinoma ablative margins using fused pre- and post-ablation hepatobiliary phase images.
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Takeyama N, Mizobuchi N, Sakaki M, Shimozuma Y, Munechika J, Kajiwara A, Uchikoshi M, Uozumi S, Ohgiya Y, and Gokan T
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- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Liver diagnostic imaging, Liver surgery, Magnetic Resonance Imaging methods, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Carcinoma, Hepatocellular diagnostic imaging, Carcinoma, Hepatocellular surgery, Catheter Ablation methods, Image Interpretation, Computer-Assisted methods, Liver Neoplasms diagnostic imaging, Liver Neoplasms surgery, Margins of Excision
- Abstract
Purpose: To retrospectively evaluate the utility of fusion images of pre- and post-ablation hepatobiliary phase (HBP) series to assess the ablation margins after radiofrequency ablation (RFA) of hepatocellular carcinomas (HCCs). Additionally, to identify factors indicative of an adequate ablation margin and predictors of local tumor progression (LTP)., Methods: Fifty-nine HCCs in 29 patients were treated by RFA and followed-up for > 1 year (mean 37.9 months). Fusion images of pre- and post-ablation HBP series were created using a non-rigid registration and manual correlation. The ablation margin appearance was classified as ablation margin + (ablation margin completely surrounding the tumor), ablation margin-zero (a partially discontinuous ablation margin without protrusion of HCC), ablation margin-(a partially discontinuous ablation margin with protrusion of HCC), and indeterminate (index tumor was not visible). The minimal ablation margin was measured, and clinical factors were examined to identify other risk factors for LTP., Results: LTP was observed at follow-up in 12 tumors. The mean minimal ablation margin was 3.6 mm. Multivariate analysis revealed that the ablation margin status was the only significant factor (p = 0.028). The cumulative LTP rates (3.3%, 3.3%, and 3.3% at 1, 2, and 3 years, respectively) in 30 ablation margin + nodules were significantly lower (p = 0.006) than those (20.0%, 28.0%, and 32.2% at 1, 2, and 3 years, respectively) in 25 ablation margin-zero nodules., Conclusions: Fusion images enable an early assessment of the ablation efficacy in the majority of HCCs. The ablation margin status is a significant factor for LTP.
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- 2019
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29. Three cases of intracystic papillary neoplasm of gallbladder.
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Mizobuchi N, Munechika J, Takeyama N, Ohgiya Y, Ohike N, Abe R, Takahama N, Miyagami O, Hatano K, Ishizuka K, Hirose M, and Gokan T
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- Aged, Aged, 80 and over, Carcinoma, Papillary surgery, Contrast Media, Female, Gallbladder diagnostic imaging, Gallbladder surgery, Gallbladder Neoplasms surgery, Humans, Male, Middle Aged, Radiographic Image Enhancement, Carcinoma, Papillary diagnostic imaging, Gallbladder Neoplasms diagnostic imaging, Magnetic Resonance Imaging methods, Tomography, X-Ray Computed methods
- Abstract
Intracystic papillary neoplasm (ICPN) of gallbladder is a comparatively new concept and is described as pre-malignant lesions in Nakanuma et al. (In: Bosman et al. (eds) WHO Classification of Tumours of the Digestive System, World Health Organization of Tumours, IARC, Lyon, 2010). ICPN with high-grade intraepithelial neoplasia is understood to include intraepithelial carcinoma or noninvasive carcinoma. And lesions with invasive cancer components are classified as ICPN with an associated invasive carcinoma [1]. According to Adsay et al., more than half of patients diagnosed with ICPN have invasive cancer components (Adsay et al., Am J Surg Pathol 36:1279-1301, 2012).Polypoid masses in the gallbladder including benign, malignant, and non-neoplastic lesions have been called gallbladder polyps, and ICPN is also a polypoid lesion in the gallbladder. However, it is difficult to differentiate between them. In the literature, it is said that the possibility of malignancy is high in lesions exceeding 1 cm (Terzi et al., Surgery 127:622-627, 2000). And there are few reports on characteristic imaging findings of ICPN.We have experienced three cases (two females and one male) of ICPN and report our imaging findings. Contrast-enhanced computed tomography revealed large papillary polypoid lesions approximately 2-4 cm in size in the gallbladder. Findings suggestive of deformation of the gallbladder wall and extrinsic progression were absent in all cases. T2-weighted magnetic resonance imaging revealed intense signals and diffusion-weighted imaging showed high intensity. Expanding of the gallbladder was seen in case 1, and a tumor stalk-like appearance was seen in the papillary mass in cases 2 and 3. Surgery was performed in all three cases and ICPN was diagnosed pathologically. The cancer was localized to the mucosa, with no infiltration of surrounding tissue in all three cases.
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- 2018
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30. CT features for diagnosing acute torsion of uterine subserosal leiomyoma.
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Ohgiya Y, Seino N, Miyamoto S, Takeyama N, Hatano K, Munechika J, Ishizuka K, Hirose M, Ohike N, Hashimoto T, Sekizawa A, and Gokan T
- Subjects
- Adult, Aged, Aged, 80 and over, Contrast Media, Female, Humans, Middle Aged, Radiographic Image Enhancement methods, Leiomyoma diagnostic imaging, Tomography, X-Ray Computed methods, Uterine Neoplasms diagnostic imaging
- Abstract
Purpose: To evaluate the usefulness of computed tomographic (CT) features for identifying acute torsion of uterine subserosal leiomyoma (USL)., Subjects and Methods: We analyzed contrast-enhanced CT examinations of 7 USLs with torsion and 44 USLs without torsion. Two radiologists evaluated the CT features, which consisted of poor contrast enhancement inside the USL, thin rim enhancement around the USL, calcification within the USL, a beak sign between the uterus and USL, fan-shaped poor contrast enhancement in the uterus area adjacent to the USL (dark fan sign), and ascites. We analyzed the frequencies of these CT features in the USLs with versus without torsion using Fisher's exact test., Results: The respective frequencies of CT features in USLs with and without torsion were as follows: poor contrast enhancement, 86 and 5% (P = 0.001); thin rim enhancement, 71 and 9% (P = 0.001); calcification, 29 and 18% (P = 0.61); beak sign, 57 and 86% (P = 0.10); dark fan sign, 57 and 0% (P = 0.001); and ascites, 100 and 20% (P = 0.01)., Conclusions: The CT features of poor contrast enhancement, thin rim enhancement, and dark fan sign are valuable for identifying acute torsion of USL.
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- 2018
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31. Evaluation and Coil Embolization of the Aortic Side Branches for Prevention of Type II Endoleak after Endovascular Repair of Abdominal Aortic Aneurysm.
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Aoki A, Maruta K, Hosaka N, Omoto T, Masuda T, and Gokan T
- Abstract
Objectives : Aneurysm shrinkage after EVAR is the strong factor of favorable outcomes after endovascular abdominal aortic aneurysm repair (EVAR), and type II endoleaks is the risk factor of no aneurysm shrinkage or aneurysm enlargement in the long term. In this study, we evaluate the aortic side branches relate to early postoperative type II endoleak, and performed coil embolization for those vessels for prevention of type II endoleak. Methods : Patency and diameter of aortic side branches including inferior mesenteric artery (IMA) and lumbar artery (LA) were evaluated in 56 consecutive patients with abdominal aortic aneurysm who were scheduled for EVAR. Coil embolization with Interlock was performed in 24 patients during EVAR for all patent IMA and LA with maximal diameter more than 2.0 mm. Computed tomography was performed one week after EVAR for evaluation of endoleak. Results : In patients with IMA more than 2.5 mm in diameter, the frequency of type II endoleak was approximately 90% regardless of the number of patent LA. In case with patent IMA less than 2.5 mm or with 2 or more patent LA larger than 2.0 mm, the frequency of type II endoleak was 46 to 67%. Coil embolization for IMA was successfully performed in 15/16 patients (94%). Coil embolization of LA was performed for patent LA larger than 2.0 mm and 29 out of 45 LA (64%) were successfully occluded. There was no perioperative complication associated with coil embolization. The frequency of type II endoleak was significantly lower in patients with coil embolization than those without coil embolization (4.2% vs 58.9%, p<0.0001). Conclusion : Patent IMA and LA in diameter larger than 2.0 mm were associated with type II endoleak one week after EVAR, and coil embolization with Interlock during EVAR is safe and effective procedure to prevent type II endoleak. (This is a translation of Jpn J Vasc Surg 2016; 25: 321-328.).
- Published
- 2017
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32. Accumulation of 123 I-Ioflupane Is a Useful Marker of the Efficacy of Selegiline Monotherapy in Drug-Naïve Parkinson's Disease.
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Murakami H, Nohara T, Uchiyama M, Owan Y, Futamura A, Shiromaru A, Tsukada S, Saito Y, Kuroda T, Yano S, Ishigaki S, Katoh H, Munechika J, Ohgiya Y, Gokan T, and Ono K
- Abstract
Background : Selegiline enhances the patient's endogenous dopamine by inhibiting dopamine metabolism. The efficacy of selegiline monotherapy for drug-naïve Parkinson's disease (PD) patients may depend on the degree of dopaminergic neuronal degeneration.
123 I-Ioflupane single photon emission computed tomography (SPECT) and123 I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy are diagnostic methods to assess the pharmacological and pathological changes in PD. Objective : We examined the utility of these imaging methods to predict the efficacy of selegiline monotherapy for motor symptoms in drug-naïve PD patients. Methods : We observed the efficacy of selegiline monotherapy in 28 drug-naïve PD patients and compared the improvement in motor function and the imaging findings. These patients received selegiline monotherapy, and the amount was increased to the optimal dose in clinical practice. Motor function was assessed using the Unified Parkinson's Rating Scale (UPDRS) at baseline and at the stable dose. Imaging was performed before treatment, and the striatal Specific Binding Ratio (SBR) of the123 I-Ioflupane SPECT and the Heart-to-Mediastinum (H/M) ratio of the123 I-MIBG myocardial scintigraphy were calculated. Both ratios were compared with improvements in scores for motor assessment using Pearson's correlation coefficient. Results : The mean UPDRS part III score significantly improved with at least 5.0 mg/day of selegiline. Further dose escalation did not improve the mean motor score. The percent improvement in the motor score from baseline showed a significant negative correlation with the SBR of average of the right and left striatum, but not with the H/M ratio. Multiple regression analysis using patient's background factors showed that percent improvement in the UPDRS part III score directly correlate with the SBR ( p = 0.04), but not with the age ( p = 0.72), disease duration ( p = 0.31), baseline UPDRS part III ( p = 0.77) and the drug dose ( p = 0.26). Conclusion : PD patients with a lower accumulation of123 I-Ioflupane in the striatum can have greater improvement with selegiline monotherapy.- Published
- 2017
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33. Regional calcified plaque score evaluated by multidetector computed tomography for predicting the addition of rotational atherectomy during percutaneous coronary intervention.
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Sekimoto T, Akutsu Y, Hamazaki Y, Sakai K, Kosaki R, Yokota H, Tsujita H, Tsukamoto S, Kaneko K, Sakurai M, Kodama Y, Li HL, Sambe T, Oguchi K, Uchida N, Kobayashi S, Aoki A, Gokan T, and Kobayashi Y
- Subjects
- Aged, Aged, 80 and over, Area Under Curve, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Odds Ratio, Patient Selection, Predictive Value of Tests, ROC Curve, Retrospective Studies, Risk Factors, Severity of Illness Index, Treatment Outcome, Angina, Stable diagnostic imaging, Angina, Stable therapy, Atherectomy, Coronary, Computed Tomography Angiography methods, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease therapy, Coronary Vessels diagnostic imaging, Multidetector Computed Tomography methods, Percutaneous Coronary Intervention, Vascular Calcification diagnostic imaging, Vascular Calcification therapy
- Abstract
Background: Rotational atherectomy (rotablation) has been proposed as a potentially superior strategy for percutaneous coronary intervention (PCI) in complex and severely calcified lesions., Objectives: We hypothesized that a per-lesion coronary artery calcium score determined by multidetector computed tomography (MDCT) would be useful for predicting the requriement for rotablation during PCI., Methods: MDCT was performed in patients with stable angina pectoris who were scheduled for first PCI. In 116 consecutive subjects (168 target lesions) with successful PCI, MDCT and quantitative coronary angiography (QCA) data were retrospectively evaluated regarding their ability to predict rotablation., Results: PCI without rotablation was performed in 105 patients (154 lesions), and rotablation was added in 11 patients (14 lesions). Patients with rotablation had significantly higher SYNTAX scores (p = 0.007) and total calcium scores (p < 0.001) than those without rotablation. Per-lesion, a lesion length ≥20 mm and diameter stenosis ≥74% on QCA as well as a per-lesion calcium score ≥453 and calcification arc ≥270 in MDCT predicted rotablation. After adjustment for potential confounding variables, a high per-lesion calcium score was an independent predictor of rotablation (odds ratio 31.3, 95% confidence interval 2.8-345, p = 0.005, sensitivity 93% and specificity 88%)., Conclusion: The extent of target lesion calcification in MDCT, a simple marker of calcified plaque, is useful for predicting the need for rotablation during PCI., (Copyright © 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
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34. Dataset of calcified plaque condition in the stenotic coronary artery lesion obtained using multidetector computed tomography to indicate the addition of rotational atherectomy during percutaneous coronary intervention.
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Akutsu Y, Hamazaki Y, Sekimoto T, Kaneko K, Kodama Y, Li HL, Suyama J, Gokan T, Sakai K, Kosaki R, Yokota H, Tsujita H, Tsukamoto S, Sakurai M, Sambe T, Oguchi K, Uchida N, Kobayashi S, Aoki A, and Kobayashi Y
- Abstract
Our data shows the regional coronary artery calcium scores (lesion CAC) on multidetector computed tomography (MDCT) and the cross-section imaging on MDCT angiography (CTA) in the target lesion of the patients with stable angina pectoris who were scheduled for percutaneous coronary intervention (PCI). CAC and CTA data were measured using a 128-slice scanner (Somatom Definition AS+; Siemens Medical Solutions, Forchheim, Germany) before PCI. CAC was measured in a non-contrast-enhanced scan and was quantified using the Calcium Score module of SYNAPSE VINCENT software (Fujifilm Co. Tokyo, Japan) and expressed in Agatston units. CTA were then continued with a contrast-enhanced ECG gating to measure the severity of the calcified plaque condition. We present that both CAC and CTA data are used as a benchmark to consider the addition of rotational atherectomy during PCI to severely calcified plaque lesions.
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- 2016
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35. MR Imaging of Fetuses to Evaluate Placental Insufficiency.
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Ohgiya Y, Nobusawa H, Seino N, Miyagami O, Yagi N, Hiroto S, Munechika J, Hirose M, Takeyama N, Ohike N, Matsuoka R, Sekizawa A, and Gokan T
- Subjects
- Female, Humans, Pregnancy, Fetus diagnostic imaging, Magnetic Resonance Imaging methods, Placental Insufficiency diagnostic imaging
- Abstract
Purpose: To evaluate morphological and signal intensity (SI) changes of placental insufficiency on magnetic resonance imaging (MRI) and to assess morphological changes and decreased flow voids (FVs) on T2-weighted rapid acquisition with relaxation enhancement (RARE) images for diagnosing placental insufficiency., Methods: Fifty singleton fetuses underwent MRI using a 1.5-T MR scanner. Placental thickness, area, volume, SI, amniotic fluid SI, and size of FVs between the uterus and the placenta were measured on MR images. Two radiologists reviewed T2-weighted RARE images for globular appearance of the placenta and FVs between the uterus and the placenta. Data were analyzed using t-tests, McNemar's tests, and areas under the receiver operating characteristic curve (AUCs) at 5% level of significance., Results: Twenty-five of the 50 pregnancies were categorized as having an insufficient placenta. Significant differences were observed between insufficient and normal placentas in mean placental thickness, area, volume, placenta to amniotic fluid SI ratio, and size of FVs (49.0 mm vs. 36.9 mm, 1.62 × 10(4) mm(2) vs. 2.67 × 10(4) mm(2), 5.13 × 10(5) mm(3) vs. 6.56 × 10(5) mm(3), 0.549 vs. 0.685, and 3.4 mm vs. 4.3 mm, respectively). The sensitivity and accuracy using globular appearance plus decreased FVs were greater than those using decreased FVs (P < 0.01). There was no significant difference among AUCs using globular appearance and decreased FVs, and globular appearance plus decreased FVs., Conclusions: Placental insufficiency was associated with placental thickness, area, volume, placenta to amniotic fluid SI ratio, and size of FVs. Evaluating FVs on T2-weighted RARE images can be useful for detecting placental insufficiency, particularly in placentas without globular appearance on MR images.
- Published
- 2016
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36. Five-year follow-up of a giant coronary aneurysm using virtual coronary angioscopy.
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Akutsu Y, Kobayashi Y, Sambe T, Kurihara T, Kaneko K, Kodama Y, Li HL, Suyama J, Hamazaki Y, Iwasaki J, Gokan T, Itabashi K, Oguchi K, Uchida N, and Kobayashi S
- Subjects
- Adolescent, Atherectomy, Coronary, Child, Coronary Aneurysm etiology, Coronary Aneurysm therapy, Coronary Stenosis diagnostic imaging, Coronary Stenosis etiology, Humans, Male, Mucocutaneous Lymph Node Syndrome diagnosis, Predictive Value of Tests, Radiographic Image Interpretation, Computer-Assisted, Time Factors, Tomography, Optical Coherence, Treatment Outcome, Vascular Calcification diagnostic imaging, Vascular Calcification etiology, Young Adult, Angioscopy methods, Coronary Aneurysm diagnostic imaging, Coronary Angiography methods, Mucocutaneous Lymph Node Syndrome complications, Multidetector Computed Tomography
- Published
- 2014
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37. Reversible T-wave inversions and neurogenic myocardial stunning in a patient with recurrent stress-induced cardiomyopathy.
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Akutsu Y, Kaneko K, Kodama Y, Li HL, Suyama J, Toshida T, Kayano H, Shinozuka A, Gokan T, and Kobayashi Y
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- 3-Iodobenzylguanidine, Aged, Earthquakes, Electrocardiography methods, Electrophysiology methods, Female, Humans, Iodine Radioisotopes, Life Change Events, Myocardial Stunning complications, Myocardial Stunning diagnostic imaging, Radionuclide Imaging, Radiopharmaceuticals, Recurrence, Stress, Psychological complications, Stress, Psychological physiopathology, Takotsubo Cardiomyopathy complications, Takotsubo Cardiomyopathy diagnostic imaging, Myocardial Stunning physiopathology, Takotsubo Cardiomyopathy physiopathology
- Abstract
A 72-year-old female was diagnosed as a stress-induced cardiomyopathy from apical ballooning pattern of left ventricular dysfunction without coronary artery stenosis after the mental stress. ECG showed the transient T-wave inversions after the ST-segment elevations. By the mental stress after 1 year, she showed a transient dysfunction with similar ECG changes again. T-wave inversions recovered earlier, and cardiac sympathetic dysfunction showed a lighter response corresponding to the less severe dysfunction than those after the first onset. Wellens' ECG pattern was associated with the degree of neurogenic myocardial stunning with sympathetic hyperinnervation caused by mental stress., (©2013 Wiley Periodicals, Inc.)
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- 2014
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38. Preoperative T staging of urinary bladder cancer: efficacy of stalk detection and diagnostic performance of diffusion-weighted imaging at 3T.
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Ohgiya Y, Suyama J, Sai S, Kawahara M, Takeyama N, Ohike N, Sasamori H, Munechika J, Saiki M, Onoda Y, Hirose M, and Gokan T
- Subjects
- Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Image Interpretation, Computer-Assisted methods, Image Processing, Computer-Assisted methods, Male, Middle Aged, Neoplasm Grading, Observer Variation, Reproducibility of Results, Sensitivity and Specificity, Diffusion Magnetic Resonance Imaging methods, Preoperative Care methods, Urinary Bladder pathology, Urinary Bladder Neoplasms pathology
- Abstract
Purpose: We evaluated the ability of diffusion-weighted imaging (DWI) at 3 tesla for diagnosing T stage and detecting stalks in bladder cancer., Methods: In total, 39 consecutive patients with bladder tumors underwent magnetic resonance (MR) imaging that included T2-weighted imaging (T2WI) and DWI using a 3T MR scanner. Two radiologists interpreted T2WI plus DWI and T2WI for diagnosis of T stage and for detection of stalks. We used McNemar's test to examine differences in diagnostic performance and Fisher's exact test to evaluate differences in stalk detection frequency., Results: Specificity and accuracy in differentiating T1 tumors from T2 to T4 tumors were significantly better with T2WI plus DWI (83% [20/24] and 85% [33/39]) than T2WI (50% [12/24] and 67% [26/39]; P = 0.02), and accuracy for diagnosing tumor stage was significantly better with T2WI plus DWI (82% [32/39]) than T2WI alone (59% [23/39]; P = 0.03). The observers identified stalks in 11 tumors by T2WI (48% [11/23]) and 17 by DWI (74% [17/23]) (P < 0.03)., Conclusion: DWI at 3T was superior to T2WI for evaluating the T stage of bladder cancer, particularly in differentiating T1 tumors from those T2 or higher, and in detecting stalks of papillary bladder tumors.
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- 2014
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39. Utility of apparent diffusion coefficients in the evaluation of solid renal tumors at 3T.
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Sasamori H, Saiki M, Suyama J, Ohgiya Y, Hirose M, and Gokan T
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- Adult, Aged, Angiomyolipoma pathology, Biopsy, Carcinoma, Renal Cell pathology, Contrast Media, Female, Gadolinium, Gadolinium DTPA, Heterocyclic Compounds, Humans, Male, Middle Aged, Organometallic Compounds, Reproducibility of Results, Retrospective Studies, Diffusion Magnetic Resonance Imaging methods, Kidney Neoplasms pathology
- Abstract
Purpose: We assessed the usefulness of apparent diffusion coefficients (ADCs) for solid renal tumor imaging using diffusion-weighted magnetic resonance imaging (DWI) at 3T., Methods: This retrospective study assessed ADCs of 31 patients with renal tumors that were imaged using preoperative DWI. DWI was performed with the b values of 50, 500, and 1000 s/mm(2), using a 3T magnetic resonance imaging (MRI) system (MAGNETOM Trio, 3T, Siemens Healthcare, Erlangen, Germany). The ADC map was calculated using the b values of 50 and 1000 s/mm(2). ADCs of the different tumors were compared according to the Tukey-Kramer test., Results: The tumors were diagnosed as clear cell renal cell carcinoma (RCC; n = 20), papillary RCC (n = 1), infiltrating urothelial carcinoma (UC) of the kidney (n = 4), cystic RCC (n = 1), poorly differentiated carcinoma (n = 1), and angiomyolipoma (AML; n = 4). The mean ADC of clear cell RCC was significantly higher than that of infiltrating UC of the kidney (1.423 vs. 0.931 × 10(-3) mm(2)/s; P < 0.05), and the mean ADC of AML was significantly lower than that of clear cell RCC (0.674 vs. 1.423 × 10(-3) mm(2)/s; P < 0.01)., Conclusion: ADCs used in DWI at 3T may be useful for differentiation of different types of solid renal tumors.
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- 2014
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40. Stratified three-dimensional fusion imaging of delayed enhancement magnetic resonance and multi-detector computed tomography to identify a ventricular tachycardia focus,.
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Akutsu Y, Kaneko K, Kodama Y, Li HL, Suyama J, Watanabe N, Asano T, Hamazaki Y, Tanno K, Gokan T, and Kobayashi Y
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- Action Potentials, Angioplasty, Balloon, Coronary, Anterior Wall Myocardial Infarction diagnosis, Anterior Wall Myocardial Infarction therapy, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Predictive Value of Tests, Tachycardia, Ventricular etiology, Tachycardia, Ventricular pathology, Tachycardia, Ventricular physiopathology, Anterior Wall Myocardial Infarction complications, Heart Conduction System pathology, Heart Conduction System physiopathology, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Multidetector Computed Tomography, Multimodal Imaging methods, Tachycardia, Ventricular diagnosis
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- 2013
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41. A combination of P wave electrocardiography and plasma brain natriuretic peptide level for predicting the progression to persistent atrial fibrillation: comparisons of sympathetic activity and left atrial size.
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Akutsu Y, Kaneko K, Kodama Y, Miyoshi F, Li HL, Watanabe N, Asano T, Tanno K, Suyama J, Namiki A, Gokan T, and Kobayashi Y
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- Aged, Atrial Fibrillation epidemiology, Biomarkers blood, Chronic Disease, Disease Progression, Disease-Free Survival, Echocardiography statistics & numerical data, Female, Follow-Up Studies, Humans, Incidence, Japan epidemiology, Male, Middle Aged, Organ Size, Prevalence, Reproducibility of Results, Risk Assessment, Sensitivity and Specificity, Atrial Fibrillation blood, Atrial Fibrillation diagnosis, Electrocardiography statistics & numerical data, Heart Atria diagnostic imaging, Natriuretic Peptide, Brain blood, Stroke Volume
- Abstract
Purpose: Development of atrial fibrillation (AF) is complexly associated with electrical and structural remodeling and other factors every stage of AF development. We hypothesized that P wave electrocardiography with an elevated brain natriuretic peptide (BNP) level would be associated with the progression to persistence from paroxysmal AF., Methods: P wave electrocardiography such as a maximum P wave duration (MPWD) and dispersion by 12-leads ECG, heart/mediastinum (H/M) ratio by delayed iodine-123 metaiodobenzylguanidine scintigraphic imaging, left ventricular ejection fraction (LVEF), and left atrial dimension (LAD) by echocardiography, and plasma BNP level were measured to evaluate the electrical and structural properties and sympathetic activity in 71 patients (mean ± standard deviation, age: 67 ± 13 years, 63.4 % males) with idiopathic paroxysmal AF., Results: Over a 12.9-year follow-up period, AF developed into persistent AF in 30 patients. A wider MPWD (>129 ms) (p = 0.001), wider P wave dispersion (>60 ms) (p = 0.001), LAD enlargement (>40 mm) (p = 0.001), higher BNP level (>72 pg/mL) (p = 0.002), lower H/M ratio (≤2.7) (p = 0.025), and lower LVEF (≤60 %) (p = 0.035) were associated with the progression to persistent AF, and the wide MPWD was an independently powerful predictor of the progression to persistent AF with a hazard ratio (HR) of 5.49 [95 % confidence interval (CI) 2.38-12.7, p < 0.0001] after adjusting for potential confounding variables, such as age and sex. The combination of wide MPWD and elevated BNP level was additive and incremental prognostic power with 13.3 [2.16-13, p < 0.0001]., Conclusion: The wide MPWD with elevated BNP level was associated with the progression to persistent AF.
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- 2013
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42. Usefulness of severe cardiac sympathetic dysfunction to predict the occurrence of rapid atrial fibrillation in patients with Wolff-Parkinson-White syndrome.
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Akutsu Y, Kaneko K, Kodama Y, Li HL, Asano T, Suyama J, Tanno K, Namiki A, Shinozuka A, Gokan T, and Kobayashi Y
- Subjects
- 3-Iodobenzylguanidine, Adult, Aged, Atrial Fibrillation complications, Case-Control Studies, Electrophysiologic Techniques, Cardiac, Female, Heart diagnostic imaging, Humans, Male, Middle Aged, Myocardial Perfusion Imaging, Radiopharmaceuticals, Severity of Illness Index, Sympathetic Nervous System physiopathology, Tachycardia, Supraventricular complications, Wolff-Parkinson-White Syndrome complications, Atrial Fibrillation diagnostic imaging, Heart innervation, Mediastinum diagnostic imaging, Sympathetic Nervous System diagnostic imaging, Tachycardia, Supraventricular diagnostic imaging, Wolff-Parkinson-White Syndrome diagnostic imaging
- Abstract
Atrial fibrillation (AF) can be a potentially life-threatening arrhythmia when it conducts rapidly through the accessory pathway, which was not predicted by the noninvasive method. We evaluated the cardiac sympathetic activity for predicting the occurrence of AF in patients with Wolff-Parkinson-White (WPW) syndrome. Iodine-123 metaiodobenzylguanidine scintigraphy was performed under stable sinus rhythm conditions at rest <1 week before an electrophysiologic study (EPS) to assess the sympathetic activity using the heart/mediastinum (H/M) ratio in 45 consecutive patients with WPW who had a history of supraventricular tachycardia (mean ± SD, age: 47 ± 17 years, 42.2% women). The study also included 15 normal healthy volunteers (56 ± 17 years, 40% women). The H/M ratio was lower in patients with WPW syndrome than in the normal control group, and in the 15 patients with AF induced during EPS than in the 30 patients without AF (p <0.0001). The sensitivity of H/M ratio ≤2.8 for predicting the AF induced during EPS was 75% in 12 of 16 patients, and the specificity was 89.7% in 26 of 29 patients. The H/M ratio was positively correlated with anterograde effective refractory period (r = 0.514, p <0.0001). The sensitivity of H/M ratio ≤2.75 for predicting the AF with a short anterograde effective refractory period (≤250 ms) was 91.7% in 11 of 12 patients, and the specificity was 90.9% in 30 of 33 patients. In conclusion, the severe cardiac sympathetic dysfunction was associated with the occurrence of AF, particularly in those with rapid AF and in patients with WPW syndrome., (Copyright © 2013 Elsevier Inc. All rights reserved.)
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- 2013
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43. Diagnostic accuracy of ultra-high-b-value 3.0-T diffusion-weighted MR imaging for detection of prostate cancer.
- Author
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Ohgiya Y, Suyama J, Seino N, Hashizume T, Kawahara M, Sai S, Saiki M, Munechika J, Hirose M, and Gokan T
- Subjects
- Aged, Biopsy, Diagnosis, Differential, Humans, Male, Prostate-Specific Antigen blood, Prostatic Neoplasms pathology, ROC Curve, Retrospective Studies, Diffusion Magnetic Resonance Imaging methods, Prostatic Neoplasms diagnosis
- Abstract
Purpose: To investigate the diagnostic accuracy of 3.0-T diffusion-weighted imaging (DWI) for detection of prostate cancer by using different b-values., Methods: Seventy-three patients underwent magnetic resonance imaging (MRI) at 3.0 T. Three MRI sets were reviewed by two radiologists: MRI and DWI (b = 500 s/mm(2)) (protocol A), MRI and DWI (b = 1000 s/mm(2)) (protocol B), and MRI and DWI (b = 2000s/mm(2)) (protocol C). Areas under the receiver operating characteristic curve (AUCs) were calculated., Results: The mean of the AUCs in protocol C was larger than those in protocol A and in protocol B (P<.05)., Conclusion: DWI (b = 2000s/mm(2)) at 3.0 T can improve the diagnostic accuracy for detection of prostate cancer., (Copyright © 2012 Elsevier Inc. All rights reserved.)
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- 2012
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44. Association between left and right atrial remodeling with atrial fibrillation recurrence after pulmonary vein catheter ablation in patients with paroxysmal atrial fibrillation: a pilot study.
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Akutsu Y, Kaneko K, Kodama Y, Suyama J, Li HL, Hamazaki Y, Tanno K, Gokan T, and Kobayashi Y
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- Atrial Fibrillation diagnostic imaging, Atrial Fibrillation surgery, Electrocardiography, Ambulatory, Female, Follow-Up Studies, Heart Atria diagnostic imaging, Heart Atria innervation, Heart Atria physiopathology, Humans, Male, Middle Aged, Pilot Projects, Recurrence, Tachycardia, Paroxysmal diagnostic imaging, Tachycardia, Paroxysmal surgery, Tomography, X-Ray Computed, Atrial Fibrillation physiopathology, Atrial Function, Left physiology, Atrial Function, Right physiology, Catheter Ablation, Heart Conduction System surgery, Pulmonary Veins surgery, Tachycardia, Paroxysmal physiopathology
- Abstract
Background: Left atrial (LA) remodeling is a factor in atrial fibrillation (AF) recurrence after pulmonary vein catheter ablation (CA), but right atrium (RA) remodeling has not been investigated for possible associations to AF recurrence., Methods and Results: Using 64-slice multidetector computed tomography, RA and LA volumes were measured 3-dimensionally before CA in 65 patients with initially proven idiopathic paroxysmal AF (mean age, 60±10 years, 81.5% men). The CA procedure was guided by CARTO Merge atrial electroanatomic mapping. Sixteen patients (24.6%) had AF recurrence within the 6-month period after the CA. The recurrence was associated with a large RA volume [odds ratio, 1.04; 95% confidence interval (CI), 1.02 to 1.07, P<0.0001], a large LA volume with 1.04 [95% CI, 1.01 to 1.06, P=0.002], and low LA mean voltage with 1.03 [95% CI, 1.01 to 1.05, P=0.002]. After adjustment for potential confounding variables, RA and LA volumes remained predictive of AF recurrence. Large atrial volumes (mL) (RA ≥87 or LA ≥99) predicted AF recurrence (sensitivity of RA volume: 81.3% in 13 of 16 patients with AF recurrence; specificity: 75.5% in 37 of 49 patients without AF recurrence; sensitivity of LA volume: 81.3% in 13 of 16 patients with AF recurrence; specificity: 69.4% in 34 of 49 patients without AF recurrence), and the combined estimate of both atrial volumes was incremental and additive prognostic power (sensitivity: 75% in 12 of 16 patients with AF recurrence; specificity: 93.9% in 46 of 49 patients without AF recurrence)., Conclusions: Both LA and RA remodeling are equally associated with post-CA AF recurrence.
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- 2011
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45. CT urography in the urinary bladder: to compare excretory phase images using a low noise index and a high noise index with adaptive noise reduction filter.
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Takeyama N, Ohgiya Y, Hayashi T, Takahashi T, Yoshiaki S, Takasu D, Nakashima J, Kato K, Kinebuchi Y, Hashimoto T, and Gokan T
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Phantoms, Imaging, Radiation Dosage, Radiographic Image Interpretation, Computer-Assisted methods, Tomography, X-Ray Computed methods, Urinary Bladder Neoplasms diagnostic imaging, Urography methods
- Abstract
Background: Although CT urography (CTU) is widely used for the evaluation of the entire urinary tract, the most important drawback is the radiation exposure., Purpose: To evaluate the effect of a noise reduction filter (NRF) using a phantom and to quantitatively and qualitatively compare excretory phase (EP) images using a low noise index (NI) with those using a high NI and postprocessing NRF (pNRF)., Material and Methods: Each NI value was defined for a slice thickness of 5 mm, and reconstructed images with a slice thickness of 1.25 mm were assessed. Sixty patients who were at high risk of developing bladder tumors (BT) were divided into two groups according to whether their EP images were obtained using an NI of 9.88 (29 patients; group A) or an NI of 20 and pNRF (31 patients; group B). The CT dose index volume (CTDI(vol)) and the contrast-to-noise ratio (CNR) of the bladder with respect to the anterior pelvic fat were compared in both groups. Qualitative assessment of the urinary bladder for image noise, sharpness, streak artifacts, homogeneity, and the conspicuity of polypoid or sessile-shaped BTs with a short-axis diameter greater than 10 mm was performed using a 3-point scale., Results: The phantom study showed noise reduction of approximately 40% and 76% dose reduction between group A and group B. CTDI(vol) demonstrated a 73% reduction in group B (4.6 ± 1.1 mGy) compared with group A (16.9 ± 3.4 mGy). The CNR value was not significantly different (P = 0.60) between group A (16.1 ± 5.1) and group B (16.6 ± 7.6). Although group A was superior (P < 0.01) to group B with regard to image noise, other qualitative analyses did not show significant differences., Conclusion: EP images using a high NI and pNRF were quantitatively and qualitatively comparable to those using a low NI, except with regard to image noise.
- Published
- 2011
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46. Right colon cancer presenting as hemorrhagic shock.
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Iwata T, Konishi K, Yamazaki T, Kitamura K, Katagiri A, Muramoto T, Kubota Y, Yano Y, Kobayashi Y, Yamochi T, Ohike N, Murakami M, Gokan T, Yoshikawa N, and Imawari M
- Abstract
A 67-year-old man visited our hospital with a history of continuous hematochezia leading to hemorrhagic shock. An abdominal computed tomography scan revealed a large mass in the ascending colon invading the duodenum and pancreatic head as well as extravasation of blood from the gastroduodenal artery (GDA) into the colon. Colonoscopy revealed an irregular ulcerative lesion and stenosis in the ascending colon. Therefore, right hemicolectomy combined with pylorus-preserving pancreaticoduodenectomy was performed. Histologically, the tumor was classified as a moderately differentiated adenocarcinoma. Moreover, cancer cells were mainly located in the colon but had also invaded the duodenum and pancreas and involved the GDA. Immunohistochemically, the tumor cells were positive for cytokeratin (CK)20 and carcinoembryonic antigen (CEA) but not for CK7 and carbohydrate antigen (CA)19-9. The patient died 23 d after the surgery because he had another episode of arterial bleeding from the anastomosis site. Although En bloc resection of the tumor with pancreaticoduodenectomy and colectomy performed for locally advanced colon cancer can ensure long-term survival, patients undergoing these procedures should be carefully monitored, particularly when the tumor involves the main artery.
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- 2011
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47. Iodine-123 mIBG Imaging for Predicting the Development of Atrial Fibrillation.
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Akutsu Y, Kaneko K, Kodama Y, Li HL, Suyama J, Shinozuka A, Gokan T, Hamazaki Y, Tanno K, and Kobayashi Y
- Subjects
- Aged, Atrial Fibrillation complications, Atrial Fibrillation physiopathology, Atrial Fibrillation therapy, Electrocardiography, Female, Heart diagnostic imaging, Heart Failure etiology, Humans, Male, Radionuclide Imaging, 3-Iodobenzylguanidine, Atrial Fibrillation diagnostic imaging, Heart innervation, Radiopharmaceuticals, Sympathetic Nervous System physiopathology
- Abstract
Objectives: we investigated whether cardiac sympathetic nervous system (SNS) activity measured by iodine-123 meta-iodobenzylguanidine ((123)I-mIBG) imaging would be associated with both the occurrence of heart failure (HF) and the transit to permanent atrial fibrillation (AF) in patients with paroxysmal AF., Background: atrial fibrillation occurs suddenly and transiently and can persist, and results in the occurrence of HF. An important feature of AF and HF is their propensity to coexist not only because they share antecedent risk factors, but also because the one may directly predispose the heart to the other. However, a useful modality for predicting the occurrences of both those has not been established in patients with paroxysmal AF., Methods: the (123)I-mIBG scintigraphy was performed to evaluate cardiac SNS activity presented as the heart/mediastinum ratio in 98 consecutive patients (age 66 ± 13 years, 63.3% male) with idiopathic paroxysmal AF and preserved left ventricular ejection fraction (≥ 50%)., Results: during 4 ± 3.6 years of follow-up, the transit to permanent AF was associated with the occurrence of HF (34.3% in 12 of 35 patients with permanent AF vs. 6.3% in 4 of 63 patients without, p < 0.0001). Lower heart/mediastinum ratio and lower left ventricular ejection fraction were the independent predictors of the transit to permanent AF with adjusted hazard ratios of 3.44 (95% confidence interval [CI]: 1.9 to 6.2, p < 0.0001) and 1.04 (95% CI: 1.01 to 1.08, p = 0.014). Further, these factors and higher plasma brain natriuretic peptide concentration were the independent predictors of the occurrence of HF with permanent AF, with adjusted hazard ratios of 5.08 (95% CI: 1.5 to 17.5, p = 0.011), 1.11 (95% CI: 1.03 to 1.19, p = 0.004), and 1.004 (95% CI: 1.001 to 1.008, p = 0.014)., Conclusions: cardiac SNS abnormality was associated with the occurrence of both HF and permanent AF in paroxysmal AF patients, and (123)I-mIBG imaging may be a useful modality for predicting the development of AF., (2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
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48. [Quantitative evaluation of low contrast detectability in a brain computed tomography: investigation for the effect of window width on recognition of hyperacute ischemic stroke].
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Nagashima H, Iwasaki T, Sunaga S, Gokan T, Fujii M, Sato K, Negishi T, Shiraishi A, Ogura T, and Doi K
- Subjects
- Female, Humans, Male, Phantoms, Imaging, ROC Curve, Sensitivity and Specificity, Brain diagnostic imaging, Radiographic Image Enhancement methods, Stroke diagnostic imaging, Tomography, X-Ray Computed methods
- Abstract
In diagnostic brain computed tomography (CT) imaging of hyperacute ischemic stroke, the recognition of subtle lesions is difficult and may be missed. The aim of this study was to evaluate quantitatively the effect of the window width on low contrast detectability by using digital phantom images intended for detection of hyperacute ischemic stroke, and clinical CT images. We first derived the digital phantom images by subtracting the simulated signal data (intensity=1-3 hounsfield units (HU), diameter=10-30 mm) from the water phantom images at various mAs values. Observer studies were then performed under the various window widths at 20, 40, 60, and 80 HU by using the 30 digital phantom images and the 30 water phantom images. In addition, observer studies on brain CT images with 30 abnormal cases and 30 normal cases were performed under the window widths at 20 and 80 HU. Studies were also performed under the simultaneous display of the set of brain CT images on each window width. As a result of evaluation by receiver operating characteristic analysis, narrowing of the window width can improve the low contrast detectability in CT images with noticeable noise, and can decrease the variation in the interpretation skills between observers in clinical CT images. Moreover, the interpretation accuracy was improved by displaying simultaneously the clinical CT image set on window widths at 20 and 80 HU.
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- 2011
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49. MRI of the neck at 3 Tesla using the periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) (BLADE) sequence compared with T2-weighted fast spin-echo sequence.
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Ohgiya Y, Suyama J, Seino N, Takaya S, Kawahara M, Saiki M, Sai S, Hirose M, and Gokan T
- Subjects
- Cysts diagnosis, Female, Head and Neck Neoplasms diagnosis, Humans, Male, Middle Aged, Artifacts, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging methods, Neck pathology
- Abstract
Purpose: To evaluate motion artifacts, tissue contrasts, and lesion detectability in the neck with the periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) (BLADE) technique., Materials and Methods: A total of 46 patients referred for MRI of the neck were included in a comparison of T2-weighted BLADE (T2W-BLADE) sequence and T2W fast spin-echo (T2W-FSE) sequence. All examinations were performed at 3T using the same parameters. Two observers evaluated unlabelled images for motion artifacts, the preferred image quality, and lesion detectability. Region of interest (ROI)-based quantitative measurements were performed to assess tissue contrasts. The frequency of occurrence of the different assessed artifacts and the lesion detectability was tested using McNemar's test. Tissue contrasts were compared using the Wilcoxon paired test. Reader agreement was assessed using kappa test., Results: T2W-BLADE showed less ghosting and pulsation artifacts than T2W-FSE (P < 0.01). T2W-BLADE images were rated as better than or equal to T2W-FSE images in majority cases (93.5%; kappa = 0.64). There was not significant difference in tissue contrasts between T2W-BLADE and T2W-FSE. A total of 32 lesions were present in 32 patients and equally well seen on T2W-BLADE and T2W-FSE., Conclusion: T2W-BLADE can reduce motion artifacts and provide tissue contrasts and lesion detectability equivalent to T2W-FSE., (© 2010 Wiley-Liss, Inc.)
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- 2010
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50. Visualization of excessive intracellular calcium ion overload caused by the occurrence of reperfusion injury.
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Akutsu Y, Hamazaki Y, Kaneko K, Kodama Y, Li HL, Suyama J, Gokan T, and Kobayashi Y
- Subjects
- Coronary Stenosis complications, Humans, Male, Middle Aged, Myocardial Infarction etiology, Myocardial Reperfusion Injury etiology, Myocardial Reperfusion Injury metabolism, Myocardium metabolism, Predictive Value of Tests, Radiopharmaceuticals, Angioplasty, Balloon, Coronary adverse effects, Calcium metabolism, Coronary Stenosis therapy, Myocardial Infarction therapy, Myocardial Reperfusion Injury diagnostic imaging, Myocardium pathology, Tomography, Emission-Computed, Single-Photon
- Published
- 2010
- Full Text
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