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2. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. 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X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. 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Oliveras, Alameda, F., Alfonso, S., Podobnik-Sarkanji, S., Pniewski, J., Torbicki, A., Mieszkowski, J., Plaza, I., Petrunjashev, V., Velcheva, I., Hadjiev, D., Yancheva, S., Petrov, L., Karakaneva, S., Petkov, A., Nikolov, E., Niehaus, L., Sacchetti, M. L., Toni, D., Fiorelli, M., Gori, C., Argentino, C., Lyrer, Ph., Radu, E. W., Gratzl, O., Rondepierre, Ph., Leclerc, X., Marchau, Jr, M., Scheltens, Ph., Hamon, M., Janssens, E., Henon, H., Lucas, C., KuÇukoglu, H., Baybas, S., Dervis, A., YalÇiner, B., Yilmaz, N., Ozturk, M., Arpaci, B., Navarro, J. A., Arenas, J., Perez-Sempere, A., Egido, J. A., Soriano-Soriano, C., Beau, P., Gergaud, J. -M., Coudero, C., Dierckx, R. A., Dobbeleir, A., Timmermans, E., Vandevivere, J., Lucas, C. H., Gomez, M., Aguirre, J., Berenguer, A., Duran, C., Parrilla, J., Gonzalez, F., Gironell, A., Rey, A., Marti-Vilalta, J. L., de Lecinana, M. Alonso, Federico, F., Conte, C., Simone, I. L., Giannini, P., Liguori, M., Lucivero, V., Picciola, E., Tortorella, C., Drislane, F., Wang, A. Ming, Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Levivier, M., del Olmo, A., Caballero, E., Degaey, I., de Bruijn, S. F. T. M., Tchaoussoglou, I., Bastianello, S., Pozzilli, C., Cervello, A., Catala, N., Koskas, F., Kieffer, E., Botia, E., Vivancos, J., Leon, T., Segura, T., Ramo, C., Lopez, F., Karepov, V. G., Gur, A. J., Berlanga, B., Gracia, V., Fiol, C., Kurtel, H., Ozkutlu, U., Yegen, B., Grau, A. J., Buggle, F., Heindle, S., Steichen-Wiehn, C., Banerjee, T., Maiwald, M., Becher, H., Villafana, W., Medina, F., Fernandez-Real, J. M., Soler, S., Planas, E., Iceman, E., Doganer, I., Badlan, G., Genc, B., Yulug, K., Ideman, E., Dural, H., Kutlul, K., Damalik, G., Baklan, Y., Metin, B., Tekinsoy, E., Iriarte, I., Subira, M. L., Crockar, A. D., Treacy, M., McNell, T. 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B., Roelcke, U., von Ammon, K., Pellikka, R., Lucking, C. H., Walon, C., Boucquey, D., -Van Rijckevorsel, K. Harmant, Lannoy, N., Verellen-Dunoulin, Ch., Liszka, U., Cavaletti, G., Casati, B., Kolig, C., Bogliun, G., Marzorati, L., Johannsen, L., Chio, A., Ruda, R., Vigliani, M. C., Sciolla, R., Seliak, D., Hoang-Xuang, K., Villanueva, J. A., Montalban, X., Arboix, A., Colosimo, C., Albanese, A., Hughes, A. J., de Bruin, V., Lees, A. J., Kowalski, J. W., Banfi, S., Santoro, L., Perretti, A., Castaldo, I., Barbieri, F., Campanella, G., Bhatia, K. P., Mardsen, C. D., de Bruin, V. S., Machedo, C., Ceballos-Baumann, D., Marsden, C. D., Brooks, D. B. J., Wennlng, G. K., Quinn, N., McDonald, W. l., Warner, T. T., Bain, P. C., Davis, M. B., Conway, D., Shaunak, S., O'Sullivan, E., Crawford, T., Lawden, M., Blunt, S., Rapoport, A., Sarova-Pinchas, I., de Beyl, D. Zegers, Mavroudakis, N., Blanc, S., Godinot, C., Lenoir, G., Barkhof, M. S. F., Tas, M. W., Baron, P. L., Constantin, C., Cassatella, M. A., Langdon, D. W., Webb, S., Gasparini, P., Zeviani, A., Kidd, D., Mammi, S., Cahalon, L., Hershkoviz, R., Lahat, N., Wallach, D., Annunziata, P., Martino, T., Maimone, D., Guazzi, G. C., Porrini, A. M., Dell'Arciprete, L., Rothwell, P. M., Stewart, R. R. C., Cull, R. E., Willmes, K., Poeck, K., Russell, D., Braekken, S. K., Brucher, R., Svennevig, J., Hermesl, M., Bruckmann, H., Biraben, A., Sliwka, U., Meyer, B., Schondube, F., Noth, J., Lavenu, I., Lammers, C., Waldecker, B., Haberbosch, W., Stam, J., Schneider, R., Gautier, J. C., Berlit, T. P., Fauser, B., Kuhne, D., Geraud, G., Danielli, A., Larrue, V., Bes, A., Timmerman, E., Bono, F., Bruni, A. C., Valalentino, P., Montesi, M. P., Talerico, G., Zappia, M., Sabatelli, M., Quattrone, A., Pareyson, D., Lorenzetti, D., Sghirlanzoni, A., Castellotti, B., Lupski, J. R., Archidiacono, N., Antonacci, R., Marzella, R., Rocchi, M., Samuel, D., Goulon-Goeau, C., Costa, P. P., Bismuth, H., Said, G., De Jongh P., Lofgren A., Timmerman V., Vance J. M., Van Broeckhoven C., Martin J. -J., Martinez, A. Cruz, Bort, S., Arpa, J., Misra, P., King, R. H. M., Badhia, K., Anderson, M., Caballo, A., Vichez, J., Gabriel, J. M., Erne, B., Miescher, G. C., Ulrich, J., Vital, A., Vital, C., Steck, A., Petry, K., Labatut, I., Hilmi, S., Ellie, E., Ferrini-Strambi, L., Zucconl, M., Marchettini, P., Palazzi, S., Oehlschlager, M., Pepinsky, R. B., Gemignani, F., Marbini, A., Pavesi, G., Di Vittorio, S., Manganelli, P., Mancia, D., Vermersh, P., Roche, J., Durocher, A. M., Dewailly, Ph., Dettmers, C., Fink, G., Lemon, R., Stephan, K., Passingham, D., Weder, B., Knorr, U., Huang, Y., Butterfield, D. A., Peris, M. L., Peiro, C., Pascual, A. Pascual-Leone, Bottini, G., Folnegovic-Smalc, V., Knezevic, S., Bokonjic, R., Ersmark, B., Torres, M. Gonzalez, Guiraud-Chaumeil, B., Haugaard, K., Jovicic, A., Chr, Lang, Levic, Z., Parra, C. Martinez, Ochoa, J. Patrignani, Titlbach, O., Wikkelso, C., Caparros-Lefevre, D., Debachy, B., Verier, A., Cantinho, G., Santos, A. I., Godinho, F., Bagunya, J., Roig, T., Ensenyat, A., Santiag, O., Trabucchi, H., De Leo, D., Koch, Ch., Zeumer, H., Matkovic, Z., Morris, P., Donaghy, M., Köhler, W., Kammer, T., Röther, J., Navon, R., Fontaine, B., Wu, Y., Capdevila, A., Guardiola, M. J., van Dijk, G. W., Notermans, N. C., Kruize, A. A., Kater, L., Bertelt, C., Hesse, S., Friedrich, H., Mauritz, K. -H., Giron, L. T., Watanabe, I. S., Ewing, D., Koepp, M., Lempert, T., Sander, B., Kauerz, U., Mehdorn, H. M., Hezel, J., Eickhoff, W., Kryst, T., Timsit, S., Gardeur, D., Reis, Mitermayer Galvao dos, Secor, E., Filho, A. Andrade, Silva, M. Cardoso, Santos, S. R. Silveira, Vasilaski, G., Reis, E. A. dos, Velupillai, P., Harn, D. A., Tigera, J. Garcia, Dreke, R. Martinez, Crespo, R. Piedra, Besses, C., Acin, P., Massons, J., Florensa, L., Oliveres, M., Sans-Sabrafen, J., Wicklein, E. M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., Donato, M., The European Velnacrine Study Group, The Dutch Guillain-Barré study group, The COP-1 Multicenter Clinical and Research Group Study, and European Study Group
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- 1994
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- View/download PDF
3. Process Optimization for Inline Black Silicon Based Solar Cell Production Line
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Raval, M.C., Gok, S., Melnyk, I., Teppe, A., Eren, T., Comak, M., Hu, B., Zhou, J., Madugula, S., Ender, M., Jooss, W., and Fath, P.
- Subjects
Manufacturing & Production of Si Cells ,Silicon Materials and Cells - Abstract
36th European Photovoltaic Solar Energy Conference and Exhibition; 410-414, Whereas technological challenges in the slicing process have been mainly solved, efforts are being undertaken to develop cost-effective and efficient technologies for texturing DWS sliced mc-Si and mono c-Si wafers. Another trigger point is the development of a texturing technology which can be applied to mc-Si and mono c-Si wafers without compromising on the optical properties. The relevance of this work is integration of Metal Catalyst Chemical Etching based inline texturing process for mc-Si and mono c-Si wafers in production environment. Average production efficiency of 18.7% is obtained for mc-Si Al-BSF cells, while average efficiency of 19.5% is obtained for mc-Si PERC trails. Production of mono PERC cells based on MCCE inline texturing resulted in average and best efficiency of 20.7% and 21.0%, respectively. Trails for inverted pyramids based texturing for mono c-Si PERC cells led to Isc value of 9.6 A which is comparable to alkaline textured reference PERC cells. This confirms that inverted pyramids based texturing is a prospective commercial alternative to standard alkaline based texturing for mono c-Si wafers with reduction in the CoO. The results also demonstrate the commercial potential of the inline process to texture multi c-Si and mono c-Si wafers for solar cell production.
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- 2019
- Full Text
- View/download PDF
4. Psychological preparedness for trauma as a protective factor in survivors of torture
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BASOGLU, M., MINEKA, S., PAKER, M., AKER, T., LIVANOU, M., and GOK, S.
- Published
- 1997
5. Investigation of the effect of aluminum porous fins on heat transfer
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Bilen, K., primary, Gok, S., additional, Olcay, A.B., additional, and Solmus, I., additional
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- 2017
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6. Apoptosis of colon cancer cells under the effect of geldanamycin derivate
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Kosova, F., primary, Kasar, Z., additional, Tuglu, I., additional, Ozdal Kurt, F., additional, Gok, S., additional, Ari, Z., additional, and Imren, T., additional
- Published
- 2017
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- View/download PDF
7. fistula formation with vaginal mesh erosion
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Karabulut, A, Demitas, O, and Gok, S
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Transobturator tape ,Mesh ,Extrusion ,Fistula ,Complication - Abstract
Transobturator tape procedures are a common treatment modality in patients with stress urinary incontinence (SUI). Various complications have been reported related to this procedure. We present a rare case of vaginocutaneous fistula formation 5 years after transobturator tape surgery. A 56-year-old woman presented with complaints of increased vaginal discharge, difficulty in coitus, and serosanguineous discharge from the left groin 5 years after transobturator tape surgery for SUI. Pelvic examination revealed 2-3 cm of extruded mesh at the anterior vaginal wall. The vaginocutaneous fistula was detected at surgery. The suburethral tape was removed, and the fistula tract was excised and repaired primarily. Postoperative period was uneventful, and the patient was still continent 6 weeks postoperatively. With widespread use of mesh for treating SUI, we will likely see a variety of complications in the long term.
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- 2014
8. P.1.k.002 Prenatal psychotropic drug exposure, birth outcome and tendency to elective termination of pregnancy
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Oztürk, Z., primary, Olmez, E., additional, Gurpinar, T., additional, Gok, S., additional, and Vural, K., additional
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- 2015
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9. The Interval Shapley Value: An Axiomatization
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Gok, S. Z. Alparslan, Branzei, R., and Tijs, S.
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Computer Science::Computer Science and Game Theory ,ComputingMilieux_PERSONALCOMPUTING ,TheoryofComputation_GENERAL - Abstract
The Shapley value, one of the most widespread concepts in operations Research applications of cooperative game theory, was defined and axiomatically characterized in different game-theoretic models. Recently much research work has been done in order to extend OR models and methods, in particular cooperative game theory, for situations with interval data. This paper focuses on the Shapley value for cooperative games where the set of players is finite and the coalition values are compact intervals of real numbers. The interval Shapley value is characterized with the aid of the properties of additivity, efficiency, symmetry and dummy player, which are straightforward generalizations of the corresponding properties in the classical cooperative game theory.
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- 2010
10. Cooperative Interval Games: A Survey
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Branzei, R., Branzei, O., Gok, S. Zeynep Alparslan, and Tijs, S.
- Subjects
ComputingMilieux_PERSONALCOMPUTING - Abstract
The (re)distribution of collective gains and costs is a central question for individuals and organizations contemplating cooperation under uncertainty. The theory of cooperative interval games provides a new game theoretical angle and suitable tools for answering this question. This survey aims to briefly present the state-of-the-art in this young field of research, discusses how the model of cooperative interval games extends the cooperative game theory literature, and reviews its existing and potential applications in economic and operations research situations with interval data.
- Published
- 2010
11. How To Handle Interval Solutions For Cooperative Interval Games
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Branzei, R., Tijs, S., and Gok, S. Z. Alparslan
- Subjects
Computer Science::Computer Science and Game Theory ,TheoryofComputation_GENERAL - Abstract
Uncertainty accompanies almost every situation in our lives and it influences our decisions. On many occasions uncertainty is so severe that we can only predict some upper and lower bounds for the outcome of our (collaborative) actions, i.e., payoffs lie in some intervals. Cooperative interval games have been proved useful for solving reward/cost sharing problems in situations with interval data in a cooperative environment. In this paper we propose two procedures for cooperative interval games. Both transform an interval allocation, i.e., a payoff vector whose components are compact intervals of real numbers, into a payoff vector (whose components are real numbers) when the value of the grand coalition becomes known (at once or in multiple stages). The research question addressed here is: How to determine for each player his/her/its a payoff generated by cooperation within the grand coalition - in the promised range of payoffs to establish such cooperation - after the uncertainty on the payoff for the grand coalition is resolved? This question is an important one that deserves attention both in the literature and in game practice.
- Published
- 2010
12. Personalized and predictive medicine in Turkey: A symposium report of the Istanbul Working Group on Personalized Medicine, Istanbul, Turkey, September 10-12, 2009
- Author
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Sardas S., Maugard C., Genc E., Gok S., Hyzel C., Bernard-Gallon D., Hizel, C., Gök, S., Sardaş, S., Bernard-Gallon, D., Maugard, C., Genç, E., and Yeditepe Üniversitesi
- Subjects
Pharmacology ,medicine.medical_specialty ,Traditional medicine ,business.industry ,Istanbul turkey ,Pharmacogenomics-guided pharmacovigilance ,Personalized medicine ,LMICs ,Predictive medicine ,Regional capacity building ,Family medicine ,Genetics ,medicine ,Molecular Medicine ,Lower and middle income countries ,business ,Molecular Biology ,Genetics (clinical) - Abstract
Pharmacogenetics has its roots in the 1950s with pioneering studies of monogenic variations in drug metabolism and pharmacokinetics. With the availability of high-throughput genomics technologies and the completion of the Human Genome Project in 2003, we are now in the postgenomics era. This transition is increasingly marked with study of polygenic and multifactorial traits such as common complex human diseases as well as pharmacodynamic differences among populations. Changes that emerge from postgenomics medicine are not, however, limited to seismic shifts in scale and scope of pharmacogenetics research. Importantly, many low- and middle-income countries (LMICs) of the South, Asia-Pacific, Eastern Mediterranean and the Middle-East are becoming notable contributors with rapid globalization of science and increasing access to genomics technologies. This brings about, in parallel, an acute demand for regional capacity building in LMICs so that the future evaluation and implementation of postgenomics technologies in personalized medicine take place in an integrated, sustainable and equitable manner. With this overarching vision, we herein report the founding of the Istanbul Working Group in Personalized Medicine (IWG-PM, represented by the authors of this report) that was inaugurated as a component of the 2nd Symposium on Personalized and Predictive Medicine held in Istanbul, sponsored by the Yeditepe University, and the Turkish Scientific and Technological Research Council (TUB?TAK) (10-12 September, 2009). While highlighting the applications of personalized medicine in oncology, psychiatry, nutrition, infectious diseases, occupational health, genetic testing and systems biology, the symposium also raised challenging questions in the context of LMICs. How can we best evaluate the promises, intended and unintended impacts of personalized medicine and enabling technologies in the context of Turkey, and the LMICs more generally? IWG-PM is a small but significant and necessary step to initiate regional capacity building in Turkey. We trust that the IWG-PM initiative may also provide a constructive example to further develop capacity in other LMICs in the Eastern Mediterranean region. © 2009 Bentham Science Publishers Ltd.
- Published
- 2009
13. A population-based questionnaire study on the prevalence and
- Author
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Kara, IG, Gok, S, Horsanli, O, and Zencir, M
- Subjects
education ,social sciences ,humanities ,health care economics and organizations - Abstract
Epidemiological investigations of burn patients help health services to identify the need for burn care and to plan burn care facilities. Various epidemiological studies on burn injury have been conducted, but they have usually covered major burn victims who required hospitalization or minor burn victims who were treated at health care centers. Few studies have included burn victims who were not admitted to any health care center. Through a population-based questionnaire, we studied the epidemiology of the entire population of burn victims, including those who did not seek medical attention. Thus, we identified the actual frequency of hospital admission and the frequency of sequelae. In total, 1068 persons from the city of Denizli, Turkey were questioned about burns in the last 10 years and the burn prevalence was found to be 12.6%. Only 33.3% of the burn victims were treated at a health care center; thus, 66.7% of the victims were treated at home with traditional burn wound care methods. Etiologic factors such as the age and sex of each victim, the cause and anatomic location of the burn, and location of the victim when burned were all investigated. The overall percentage of sequelae was 31.3%; of these, 89.5% were cosmetic problems, 7.9% were functional impairments, and 2.9% were physiological problems. The low percentage of health care center admissions and high incidence of sequelae suggest the need for professional burn care centers that can be easily reached by burn victims.
- Published
- 2008
14. P.4.c.006 Glutamate mGlu5 receptor antagonist MPEP reduces quinpirole-induced compulsive checking behaviour in rats
- Author
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Gok, S., primary, Demet, M.M., additional, and Ozturk, Z., additional
- Published
- 2014
- Full Text
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15. Reply to Kesav et al
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Ergonul, O., primary, Guven, T., additional, Ugurlu, K., additional, Celikbas, A. K., additional, Gok, s. E., additional, Comoglu, S., additional, Baykam, N., additional, and Dokuzoguz, B., additional
- Published
- 2013
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16. The renewable energy policy of Turkey
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Gok, S. Gokce, primary and Kavasoglu, Ruhsar, additional
- Published
- 2013
- Full Text
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17. Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta
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Gurpinar, T, primary and Gok, S, additional
- Published
- 2012
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18. Synthesis of 2-(2-benzimidazolyl)/2-(2-benzothiazolyl)-5-alkyl/aryl-1,2 dihydro-3H-pyrazol-3-one derivatives and their antifungal activities
- Author
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Tosun, A., Gok, S., Sahin, M. F., Ersan, S., Nacak, S., Uzunoglu, S., and Abbasoglu, U.
- Abstract
Seven 1,2-dihydro-3H-pyrazol-3-one derivatives carrying 2-benzothiazolyl- and 2-benzimidazolyl-substituents at position 2 have been synthesized. Their structures have been elucidated by using elemental analyses and their spectral data. Antifungal activity of the compounds investigated against four yeast-like fungi (Candida albicans, Candida stellatoidea, Candida parapsilosis, Candida pseudotropicalis) using rabenzazole and clotrimazole as references. The benzimidazole derivatives have been found more potent than benzothiazole congeners in general.
- Published
- 1995
19. Personalized and Predictive Medicine in Turkey: A Symposium Report of the Istanbul Working Group on Personalized Medicine, Istanbul, Turkey, September 10-12, 2009
- Author
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Hyzel, C., primary, Gok, S., additional, Sardas, S., additional, Bernard-Gallon, D., additional, Maugard, C., additional, and Genc, E., additional
- Published
- 2009
- Full Text
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20. The effect of edothelium on the response to propofol on bovine coronary artery rings
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GACAR, N., primary, GOK, S., additional, KALYONCU, N. I., additional, OZEN, I., additional, Soykan, N., additional, and AKTURK, G., additional
- Published
- 1995
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21. Prediction of Liquid and Vapor Enthalpies of Ammonia-water Mixture.
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Sencan, Arzu, Gok, S., and Dikmen, E.
- Subjects
- *
ENTHALPY , *LIQUID ammonia , *ARTIFICIAL neural networks , *REFRIGERANTS , *INFORMATION storage & retrieval systems , *INFORMATION processing , *STANDARD deviations , *STATISTICS , *BACK propagation - Abstract
The ammonia-water mixture may be commonly employed as a working fluid in the absorption chiller, especially because both ammonia and water are natural substances and are harmless. In addition, these substances have excellent thermodynamic properties. In this study, an alternative method using the artificial neural network (ANN) to determine liquid and vapor enthalpies of ammonia-water mixture is presented. The training and validation was performed with good accuracy. The correlation coefficient obtained when unknown data were used to the networks was 0.975 for the liquid enthalpy and 0.887 for the vapor enthalpy. Using the weights obtained from the trained network, a new formulation is presented for the determination of the vapor and liquid enthalpies of ammonia-water mixture. The results of the study show that the ANN is a perfect alternative method for the calculation of thermodynamic properties of ammonia-water mixture. The faster and simpler solutions with equations derived from the ANN can be carried out. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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22. The effect of nicotine among active, passive smoker health personnel.
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Temel O, Coskun AS, Gok S, Celik P, and Yorgancioglu A
- Abstract
Copyright of Turkish Thoracic Journal / Turk Toraks Dergisi is the property of Aves Yayincilik Ltd. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
23. A population-based questionnaire study on the prevalence and epidemiology of burn patients in Denizli, Turkey.
- Author
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Kara IG, Gok S, Horsanli O, Zencir M, Kara, Inci Gökalan, Gök, Soner, Horsanli, Ozan, and Zencir, Mehmet
- Published
- 2008
- Full Text
- View/download PDF
24. The antinociceptive effect of leukotriene D4 receptor antagonist, MK-571, in mice: possible involvement of opioidergic mechanism
- Author
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Gok, S., Onal, A., Cinar, M.G., and Evinc, A.
- Published
- 1999
- Full Text
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25. A Case of Leukaemia Cutis Presenting as Generalized Erythematous Nodules.
- Author
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Gok, S. O., Belli, A. A., and Dervis, E.
- Abstract
The article presents a case study of A62-year old female with generalized erythematous papules and nodules on the trunk and limbs. The diagnosis of leukaemia was considered with laboratory tests and bone marrow cytology was compatible with the peripheral blood smear and myeloperoxidase and human leukocyte antigen. Biopsy showed atypical cellular infiltration in the dermis sparing of the upper papillary dermis.
- Published
- 2016
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26. Investigation of the effect of aluminum porous fins on heat transfer
- Author
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Ali Bahadır Olcay, İsmail Solmuş, S. Gok, Kadir Bilen, Bilen, K., Gok, S., Olcay, A.B., Solmus, I., and Yeditepe Üniversitesi
- Subjects
Friction factor ,Fin ,020209 energy ,Heat transfer enhancement ,Thermodynamics ,chemistry.chemical_element ,02 engineering and technology ,Heat transfer coefficient ,Industrial and Manufacturing Engineering ,Aluminium ,Forced convection in channel ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,Composite material ,Porosity ,Civil and Structural Engineering ,Pressure drop ,Aluminum porous fins ,Mechanical Engineering ,Building and Construction ,021001 nanoscience & nanotechnology ,Pollution ,Nusselt number ,General Energy ,chemistry ,Heat transfer ,0210 nano-technology - Abstract
In the present study, heat transfer and pressure drop characteristics of aluminum porous fins mounted on a surface in a rectangular channel were studied. Nusselt number, heat transfer enhancement ratio and heat transfer performance for three gap heights over pore fins (C/H = 0, 0.5 and 1) as well as three longitudinal fin pitches (Sx = 116, 126 and 136 mm) were investigated for the range of 5000 < Re < 35000. It was found that use of larger gap height over fins has a significant effect on the Nusselt number while the longitudinal fin pitch has a negligible influence on it. The highest heat enhancement ratio (Nu*) was obtained as 470–660% for the case of C/H = 0 and Sx = 136 mm. Furthermore, the highest heat transfer performance (?) was in the range of 1.7–2.6 for the case of C/H = 1 and Sx = 136 mm. The highest heat enhancement ratio (Nu*) was obtained for C/H = 0 and Sx = 136 mm while the highest heat transfer performance (?) was obtained for C/H = 1 and Sx = 136 mm. In conclusion, the heat transfer performances (?) studied are advantageous for all fin and channel arrangements, since heat transfer performances (?) for all present tests are higher than unity. © 2017 Elsevier Ltd Kansas State University Research Foundation: BAP 2011/417 British Association for Psychopharmacology University of Miami This work was funded by the Ataturk University Research Foundation under BAP 2011/417 project.
- Published
- 2017
27. Learning from failure: The roles of self-focused feedback, task expectations, and subsequent instruction.
- Author
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Gok S and Fyfe ER
- Subjects
- Humans, Male, Female, Adult, Young Adult, Learning, Feedback, Psychological
- Abstract
Previous research indicates that failure feedback leads people to tune out from the task, which is detrimental to their learning (Eskreis-Winkler & Fishbach, 2019; Keith et al., 2022). The current work aims to identify ways to optimize learning from failure feedback. We conducted six preregistered experiments ( N = 1,306) to replicate and extend the findings from Eskreis-Winkler and Fishbach (2019) with novel tests of self-focused feedback, task expectations, and subsequent instruction. The detriments of failure feedback were replicated in Studies 1a, 1b, and 1c, which altered the focus of the feedback message to be self-focused (e.g., your answer) or task-focused (e.g., the answer). The detriments of failure feedback were also replicated in Study 2 when the task expectations were manipulated to easy versus hard. These results generally underscored the robustness of the results from the original study. However, Study 3 established boundary conditions. When it was a rule-based task and brief instructions on the rule were provided after feedback, there was no evidence of a detrimental effect of failure, and failure feedback, in some conditions, resulted in even better learning than success feedback for learning new material. We conclude that the tune-out reactions to failure during feedback disappear and may even be reversed when subsequent learning opportunities are provided. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
- Published
- 2024
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- View/download PDF
28. How do students reason about statistical sampling with computer simulations? An integrative review from a grounded cognition perspective.
- Author
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Gok S and Goldstone RL
- Subjects
- Humans, Students, Cognition physiology, Thinking physiology, Computer Simulation
- Abstract
Interactive computer simulations are commonly used as pedagogical tools to support students' statistical reasoning. This paper examines whether and how these simulations enable their intended effects. We begin by contrasting two theoretical frameworks-dual processes and grounded cognition-in the context of people's conceptions about statistical sampling, setting the stage for the potential benefits of simulations in learning such conceptions. Then, we continue with reviewing the educational literature on statistical sampling simulations. Our review tentatively suggests benefits of the simulations for building statistical habits of mind. However, challenges seem to persist when more specific concepts and skills are investigated. With and without simulations, students have difficulty forming an aggregate view of data, interpreting sampling distributions, showing a process-based understanding of the law of large numbers, making statistical inferences, and context-independent reasoning. We propose that grounded cognition offers a framework for understanding these findings, highlighting the bidirectional relationship between perception and conception, perceptual design features, and guided perceptual routines for supporting students' meaning making from simulations. Finally, we propose testable instructional strategies for using simulations in statistics education., (© 2024. The Author(s).)
- Published
- 2024
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29. The Preoperative Use of Gabapentinoids for the Treatment of Acute Postoperative Pain Following Lumbar Spine Fixation Surgery.
- Author
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Karaaslan A, Gok S, and Basaran R
- Abstract
Background: Postoperative pain following posterior fixation is caused not only by tissue injury during surgery and is related to inflammatory, neuropathic, and visceral pain. This study aims to answer the question, "Is there a role for gabapentinoids in reducing postoperative pain?" In addition, it demonstrates which gabapentinoids may be used, for how long, and at what dose., Methods: The study was planned as a prospective, randomized, double-blind study. Lumbar posterior fixation was included and patients were divided into 9 groups. Gabapentinoids and a placebo were administered. Postoperative pain at hours 1, 6, 12, and 24 was evaluated by visual analog scale (VAS)., Results: This study included 252 patients (141 women, 111 men). The median age was 51.62 years. A statistically significant difference was found when VAS-1, VAS-6, VAS-12, and VAS-24 scores were compared between all groups (P ˂ 0.001). Single and low doses of gabapentinoids were found to be ineffective (P > 0.05). Long-term and high-dose gabapentinoids had complications (P ˂ 0.001). Single and high doses of gabapentinoids were effective and safe (P ˂ 0.001)., Conclusions: Postoperative use of gabapentin for controlling early and late-stage pain is safe and effective. Single and high-dose gabapentin was the first choice. A single and high dose of pregabalin is the second choice., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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- View/download PDF
30. Evolution of Carbonate-Intercalated γ-NiOOH from a Molecularly Derived Nickel Sulfide (Pre)Catalyst for Efficient Water and Selective Organic Oxidation.
- Author
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Ghosh S, Dasgupta B, Kalra S, Ashton MLP, Yang R, Kueppers CJ, Gok S, Alonso EG, Schmidt J, Laun K, Zebger I, Walter C, Driess M, and Menezes PW
- Abstract
The development of a competent (pre)catalyst for the oxygen evolution reaction (OER) to produce green hydrogen is critical for a carbon-neutral economy. In this aspect, the low-temperature, single-source precursor (SSP) method allows the formation of highly efficient OER electrocatalysts, with better control over their structural and electronic properties. Herein, a transition metal (TM) based chalcogenide material, nickel sulfide (NiS), is prepared from a novel molecular complex [Ni
II (PyHS)4 ][OTf]2 (1) and utilized as a (pre)catalyst for OER. The NiS (pre)catalyst requires an overpotential of only 255 mV to reach the benchmark current density of 10 mA cm-2 and shows 63 h of chronopotentiometry (CP) stability along with over 95% Faradaic efficiency in 1 m KOH. Several ex situ measurements and quasi in situ Raman spectroscopy uncover that NiS irreversibly transformed to a carbonate-intercalated γ-NiOOH phase under the alkaline OER conditions, which serves as the actual active structure for the OER. Additionally, this in situ formed active phase successfully catalyzes the selective oxidation of alcohol, aldehyde, and amine-based organic substrates to value-added chemicals, with high efficiencies., (© 2023 The Authors. Small published by Wiley-VCH GmbH.)- Published
- 2023
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31. The process of replication target selection in psychology: what to consider?
- Author
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Pittelkow MM, Field SM, Isager PM, Van't Veer AE, Anderson T, Cole SN, Dominik T, Giner-Sorolla R, Gok S, Heyman T, Jekel M, Luke TJ, Mitchell DB, Peels R, Pendrous R, Sarrazin S, Schauer JM, Specker E, Tran US, Vranka MA, Wicherts JM, Yoshimura N, Zwaan RA, and van Ravenzwaaij D
- Abstract
Increased execution of replication studies contributes to the effort to restore credibility of empirical research. However, a second generation of problems arises: the number of potential replication targets is at a serious mismatch with available resources. Given limited resources, replication target selection should be well-justified, systematic and transparently communicated. At present the discussion on what to consider when selecting a replication target is limited to theoretical discussion, self-reported justifications and a few formalized suggestions. In this Registered Report, we proposed a study involving the scientific community to create a list of considerations for consultation when selecting a replication target in psychology. We employed a modified Delphi approach. First, we constructed a preliminary list of considerations. Second, we surveyed psychologists who previously selected a replication target with regards to their considerations. Third, we incorporated the results into the preliminary list of considerations and sent the updated list to a group of individuals knowledgeable about concerns regarding replication target selection. Over the course of several rounds, we established consensus regarding what to consider when selecting a replication target. The resulting checklist can be used for transparently communicating the rationale for selecting studies for replication., (© 2023 The Authors.)
- Published
- 2023
- Full Text
- View/download PDF
32. Deficits of social cognition in bipolar disorder: Systematic review and meta-analysis.
- Author
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Gillissie ES, Lui LMW, Ceban F, Miskowiak K, Gok S, Cao B, Teopiz KM, Ho R, Lee Y, Rosenblat JD, and McIntyre RS
- Subjects
- Cognition, Cyclothymic Disorder, Humans, Social Cognition, Bipolar Disorder complications, Bipolar Disorder psychology, Cognitive Dysfunction, Theory of Mind
- Abstract
Background: The association between impaired social cognition and bipolar disorder (BD) is well established. However, to our knowledge, there has not been a recent systematic review that characterizes disparate dimensions of social cognition in BD. Herein, this systematic review and meta-analysis aimed to synthesize the literature on core aspects of social cognition (i.e., Theory of Mind, emotion recognition, and social judgment) to identify potential areas of impairment., Methods: Online databases (i.e., PubMed, Cochrane Libraries, PsycINFO) and Google Scholar were searched from inception to May 2021. Studies with populations ages ≥16 with DSM-IV or DSM-5 defined BD (I or II) either in a euthymic or symptomatic state were included. The risk of bias was measured using the ROBINS-1 tool, and the quality of the sources was evaluated using GRADE criteria. The results of the studies were quantitatively measured by synthesizing Hedge's g effect sizes through a random effects meta-analytic approach., Results: A total of 29 studies were included in the final review (i.e., 12 studies on the Theory of Mind, 11 on emotion recognition, and 6 on social judgment). Overall, results demonstrated social cognition to be moderately impaired in individuals with BD (d = 0.59). The individual domains ranged in effect size (0.38 < d < 0.70), providing evidence for variation in impairment within social cognition., Discussion: Individuals with BD exhibit clinically significant deficits in social cognition during euthymic and symptomatic states. Social cognition impairments in individuals with BD are an important therapeutic target for treatment discovery and development., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2022
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33. Selection of the mobilization regimen in lymphoma patients: A retrospective cohort study.
- Author
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Sarici A, Erkurt MA, Kuku I, Gok S, Bahcecioglu OF, Bicim S, Berber I, Kaya E, and Ozgul M
- Subjects
- Adult, Aged, Antigens, CD34 metabolism, Female, Granulocyte Colony-Stimulating Factor metabolism, Hematopoietic Stem Cell Transplantation methods, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Retrospective Studies, Transplantation, Autologous, Hematopoietic Stem Cell Mobilization methods, Hodgkin Disease therapy, Lymphoma, Non-Hodgkin therapy
- Abstract
Background and Objectives: Consolidation with autologous stem cell transplantation (ASCT) is recommended for patients with recurrent or refractory lymphoma after salvage chemotherapy. Stem cells which will be used in ASCT are provided by mobilization using granulocyte colony stimulation factor (G-CSF) or chemotherapy plus G-CSF. The aim of this study was to compare the effect of various mobilization regimens on the clinical parameters of lymphoma patients., Materials and Methods: Mobilization interventions of lymphoma patients were analysed retrospectively. The patients were divided into 3 groups according to the mobilization method implemented to collect stem cells before ASCT, (Group 1: Salvage chemotherapy plus G-CSF, Group 2: Cyclophosphamide plus G-CSF, Group 3: G-CSF alone)., Results: Analysis of CD34
+ cell counts of the 3 groups revealed a significant difference (p < 0.001). Although the number of CD34+ cells collected were different, the neutrophil and platelet engraftment of the 3 groups were similar (p > 0.05). Furthermore, the results were similar in the separate analysis of NHL and HL patients. While the mobilization success rate in group 1 was 97.8 %, it was 90.2 % in group 3. This difference showed a certain trend towards statistical significance (p = 0.074). Patients who received DHAP plus G-CSF had a higher CD34+ count, while neutrophil engraftment was shorter than with ESHAP plus G-CSF (p < 0.05)., Conclusion: Although the success rate of mobilization and number of CD34+ cell collected were higher in the salvage chemotherapy plus G-CSF than G-CSF alone, G-CSF alone group provided similar neutrophil and thrombocyte engraftment in most lymphoma patients., (Copyright © 2021. Published by Elsevier Ltd.)- Published
- 2021
- Full Text
- View/download PDF
34. Vitamin E Derivative with Modified Side Chain Induced Apoptosis by Modulating the Cellular Lipids and Membrane Dynamics in MCF7 Cells.
- Author
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Gok S, Kuzmenko O, Babinskyi A, and Severcan F
- Subjects
- Cell Proliferation drug effects, Down-Regulation drug effects, Humans, Lipid Peroxidation drug effects, MCF-7 Cells, Membrane Fluidity drug effects, Membrane Potential, Mitochondrial drug effects, Receptors, Estrogen genetics, Receptors, Estrogen metabolism, Vitamin E analogs & derivatives, alpha-Tocopherol pharmacology, Apoptosis drug effects, Lipid Metabolism drug effects, Vitamin E pharmacology
- Abstract
The vitamin E derivative with side chain modification (TC6OAc) has been shown to possess anticancer activity in our earlier in vivo studies. It was hypothesized that, as Vitamin E (VE) and VE derivative are fat soluble lipophilic molecules, they exert their function by modulating the lipid metabolism and related pathways. This study aimed to evaluate the cellular impact of this VE derivative (2,5,7,8-Tetramethyl-2-(4'-Methyl-3'-Pentenyl)-6-Acetoxy Chromane-TC6OH), using α-tocopherol as a reference compound throughout the experiments. Their effects on the cellular metabolism, the biophysical properties of cellular lipids and the functional characteristics of cells were monitored in human estrogen receptor (ER) positive breast cancer cells. It has been documented that TC6OH treatment induces tumor cell apoptosis by dissipating the mitochondrial membrane potential, modulating the lipid, transportation and degradation as well as downregulating certain anti-apoptotic and growth factor related proteins. Due to resistance of ER positive cells to the established therapies, the findings of this study are of translational value.
- Published
- 2021
- Full Text
- View/download PDF
35. Methanol Tolerant Pt-C Core-Shell Cathode Catalyst for Direct Methanol Fuel Cells.
- Author
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Lee D, Gok S, Kim Y, Sung YE, Lee E, Jang JH, Hwang JY, Kwon OJ, and Lim T
- Abstract
Methanol crossover is one of the largest problems in direct methanol fuel cells (DMFCs). Methanol passing from the anode to the cathode through the membrane is oxidized at the cathode, degrading the DMFC performance, and the intermediates of the methanol oxidation reaction (MOR) cause cathode catalyst poisoning. Therefore, it is essential to develop a cathode catalyst capable of inhibiting MOR while promoting the oxygen reduction reaction (ORR), which is a typical cathode reaction in DMFCs. In this study, a carbon-encapsulated Pt cathode catalyst was synthesized for this purpose. The catalyst was simply synthesized by heat treatment of Pt-aniline complex-coated carbon nanofibers. The carbon shell of the catalyst was effective in inhibiting methanol from accessing the Pt core, and this effect became more prominent as the graphitization degree of the carbon shell increased. Meanwhile, the carbon shell allowed O
2 to permeate regardless of the graphitization degree, enabling the Pt core to participate in ORR. The synthesized catalyst showed higher performance and stability in single-cell tests under various conditions compared to commercial Pt/C.- Published
- 2020
- Full Text
- View/download PDF
36. Composite Hemangioendothelioma Settled in the Paraspinal Region: A Rare Case Report.
- Author
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Gok S, Berkman MZ, and Baykara E
- Subjects
- Hemangioendothelioma complications, Humans, Low Back Pain etiology, Male, Middle Aged, Hemangioendothelioma pathology, Paraspinal Muscles pathology
- Abstract
Composite hemangioendothelioma (CHE) is a very rare, low-grade malignant vascular tumor. It is most commonly seen as one or more nodules on both sides of the fingers and toes. This tumor rarely settles in the paraspinal muscles. The age of onset is usually between 21 and 72 years, with an average age of 39.5-41 years. Treatment is with gross total removal of the lesion. We present a case of a 54-year-old male patient with a 2-year history of low back pain. Lumbar spine magnetic resonance imaging revealed CHE in the right paravertebral muscle in the posterior vicinity of the transverse process between the right paraspinal muscle planes. The entire mass was removed grossly. The definitive diagnosis of CHE was made histopathologically. This is a rare case of CHE that had settled in the paraspinal region.
- Published
- 2020
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- View/download PDF
37. Prediction of Forelimb EMGs and Movement Phases from Corticospinal Signals in the Rat During the Reach-to-Pull Task.
- Author
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Gok S and Sahin M
- Subjects
- Animals, Forecasting, Forelimb innervation, Rats, Rats, Long-Evans, Spinal Cord Injuries diagnosis, Spinal Cord Injuries physiopathology, Spinal Cord Injuries rehabilitation, Brain-Computer Interfaces, Electrodes, Implanted, Electromyography methods, Forelimb physiology, Movement physiology, Pyramidal Tracts physiology
- Abstract
Brain-computer interfaces access the volitional command signals from various brain areas in order to substitute for the motor functions lost due to spinal cord injury or disease. As the final common pathway of the central nervous system (CNS) outputs, the descending tracts of the spinal cord offer an alternative site to extract movement-related command signals. Using flexible 2D microelectrode arrays, we have recorded the corticospinal tract (CST) signals in rats during a reach-to-pull task. The CST activity was then classified by the forelimb movement phases into two or three classes in a training dataset and cross validated in a test set. The average classification accuracies were 8 0 ± 1 0 % (min: 6 2 % to max: 9 7 % ) and 5 5 ± 8 % (min: 43% to max: 71%) for two-class and three-class cases, respectively. The forelimb flexor and extensor EMG envelopes were also predicted from the CST signals using linear regression. The average correlation coefficient between the actual and predicted EMG signals was 0 . 5 ± 0 . 1 3 ( n = 1 2 4 ) , whereas the highest correlation was 0.81 for the biceps EMG. Although the forelimb motor function cannot be explained completely by the CST activity alone, the success rates obtained in reconstructing the EMG signals support the feasibility of a spinal-cord-computer interface as a concept.
- Published
- 2019
- Full Text
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38. Electrical fields induced inside the rat brain with skin, skull, and dural placements of the current injection electrode.
- Author
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Asan AS, Gok S, and Sahin M
- Subjects
- Animals, Craniotomy, Electric Conductivity, Electrodes, Male, Models, Animal, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Transcranial Direct Current Stimulation instrumentation, Brain physiology, Dura Mater physiology, Galvanic Skin Response physiology, Skull physiology, Transcranial Direct Current Stimulation methods
- Abstract
Transcranial electrical stimulation (tES) is rapidly becoming an indispensable clinical tool with its different forms. Animal data are crucially needed for better understanding of the underlying mechanisms of tES. For reproducibility of results in animal experiments, the electric fields (E-Fields) inside the brain parenchyma induced by the injected currents need to be predicted accurately. In this study, we measured the electrical fields in the rat brain perpendicular to the brain surface, i.e. vertical electric field (VE-field), when the stimulation electrode was placed over the skin, skull, or dura mater through a craniotomy hole. The E-field attenuation through the skin was a few times larger than that of the skull and the presence of skin substantially reduced the VE-field peak at the cortical surface near the electrode. The VE-field declined much quicker in the gray matter underneath the pial surface than it did in the white matter, and thus the large VE-fields were contained mostly in the gray matter. The transition at the gray/white matter border caused a significant peak in the VE-field, as well as at other local inhomogeneties. A conductivity value of 0.57 S/m is predicted as a global value for the whole brain by matching our VE-field measurements to the field profile given by analytical equations for volume conductors. Finally, insertion of the current return electrode into the shoulder, submandibular, and hind leg muscles had virtually no effects on the measured E-field amplitudes in the cortex underneath the epidural electrodes., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
- Full Text
- View/download PDF
39. Spinal Epidural Venous Angioma Presenting Symtomps of Lumbar Disc Herniation: A Case Report.
- Author
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Baykara E, Korucu M, Ozdemir M, and Gok S
- Subjects
- Diagnosis, Differential, Epidural Neoplasms complications, Epidural Neoplasms surgery, Hemangioma complications, Hemangioma surgery, Humans, Intervertebral Disc Displacement complications, Intervertebral Disc Displacement surgery, Lumbar Vertebrae surgery, Magnetic Resonance Imaging methods, Male, Middle Aged, Neurilemmoma complications, Neurilemmoma surgery, Epidural Neoplasms diagnostic imaging, Hemangioma diagnostic imaging, Intervertebral Disc Displacement diagnostic imaging, Lumbar Vertebrae diagnostic imaging, Neurilemmoma diagnostic imaging
- Abstract
Spinal epidural venous angiomas are extremely rare. We report the case of a 60-year-old man who presented with disc herniation symptoms, complaining of pain in his left leg and numbness, especially at the base of the knee. On physical examination, the Lasègue test was positive at 45 degrees on the left side and no neurological deficit was detected on the lower extremity. Contrast enhanced magnetic resonance imaging revealed a lesion in the left S1 neural foramen, which was initially evaluated as a schwannoma. However, after the lesion was totally excised, it was pathologically identified as a venous angioma. Here, the clinical presentation, management, and surgical, radiological, and pathological features are discussed.
- Published
- 2019
- Full Text
- View/download PDF
40. Convolutional Networks Outperform Linear Decoders in Predicting EMG From Spinal Cord Signals.
- Author
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Guo Y, Gok S, and Sahin M
- Abstract
Advanced algorithms are required to reveal the complex relations between neural and behavioral data. In this study, forelimb electromyography (EMG) signals were reconstructed from multi-unit neural signals recorded with multiple electrode arrays (MEAs) from the corticospinal tract (CST) in rats. A six-layer convolutional neural network (CNN) was compared with linear decoders for predicting the EMG signal. The network contained three session-dependent Rectified Linear Unit (ReLU) feature layers and three Gamma function layers were shared between sessions. Coefficient of determination ( R
2 ) values over 0.2 and correlations over 0.5 were achieved for reconstruction within individual sessions in multiple animals, even though the forelimb position was unconstrained for most of the behavior duration. The CNN performed visibily better than the linear decoders and model responses outlasted the activation duration of the rat neuromuscular system. These findings suggest that the CNN model implicitly predicted short-term dynamics of skilled forelimb movements from neural signals. These results are encouraging that similar problems in neural signal processing may be solved using variants of CNNs defined with simple analytical functions. Low powered firmware can be developed to house these CNN solutions in real-time applications.- Published
- 2018
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41. Carbon Fiber Electrodes for in Vivo Spinal Cord Recordings.
- Author
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Cetinkaya E, Gok S, and Sahin M
- Subjects
- Animals, Electrodes, Implanted, Microelectrodes, Carbon Fiber, Spinal Cord
- Abstract
Development of micro electrode arrays for neural recording is an active field that thrives on novel materials and fabrication techniques offered by micro fabrication technology. The material and mechanical properties of microelectrode arrays have a critical role on the quality and longevity of neural signals. In this study, carbon fiber microelectrode (CFME) bundles were developed and implanted in the spinal cord of experimental animals for textbf{\textit{in vivo{recording. Neural data analysis revealed that single spikes could successfully be recorded and sorted. Removal of approximately $75 \mu \mathrm{m}$ of the parylene-C coating at the tips of the fibers increased the signalto-noise ratio. Connecting multiple (three) carbon fiber filaments to the same recording channel did not deteriorate the signal quality compared to that of undesheathed fibers. Immunohistochemistry showed that electrode tips were splayed in tissue after implantation and CF bundles had a small footprint with mild encapsulation around them. These results are very promising for the use of CFME bundles for recordings of spinal cord signals in behaving animals.
- Published
- 2018
- Full Text
- View/download PDF
42. Electric Fields Induced By Transcutaneous And Intracranial Current Injections In The Rat Brain.
- Author
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Asan AS, Gok S, and Sahin M
- Subjects
- Animals, Brain physiology, Electrodes, Models, Animal, Rats, Electromagnetic Phenomena, Motor Cortex, Transcranial Direct Current Stimulation
- Abstract
As a non-invasive brain stimulation technique, transcranial electrical stimulation (TES) and specifically the transcranial direct current stimulation (tDCS) has gained popularity in recent years for treatment of a wide variety of cognitive and neurological disorders. Recent studies have shown that TES can alter the motor cortex excitability. Animal studies to demonstrate the underlying mechanisms of TES are clearly lacking in literature. Clinical studies have agreed on the critical role of the current intensity and the montage of the electrodes for the treatment to be effective. In this study, we used a rat model for in vivo investigation of the vertical electrical (E) field distribution due to electrodes placed over the skin and through a craniotomy hole. A mono-phasic current pulse was used as a substitute for DC currents by taking advantage of primarily resistive properties of the brain tissue at low frequencies. The electrical potentials induced by the current pulses were recorded with penetrations at 0mm, 2mm, and 4mm away from the stimulation electrode. The results showed that the E-field was maximum immediately under the anodic electrode and decreased both in the vertical and horizontal directions rapidly by distance. The magnitude of the electric field varied from tens of mV/mm to a fraction of mV/mm by distance for a 100 μ A stimulus amplitude. The results also show that the E-field amplitudes and distribution strongly depend on whether the stimulus electrode is placed over the skin or into a craniotomy hole.
- Published
- 2018
- Full Text
- View/download PDF
43. Can Hematologic Parameters be an Indicator of Metabolic Disorders Accompanying Rosacea?
- Author
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Akin Belli A, Kara A, and Ozbas Gok S
- Subjects
- Adult, Aged, Case-Control Studies, Female, Humans, Male, Metabolic Diseases blood, Middle Aged, Rosacea diagnosis, Sensitivity and Specificity, Metabolic Diseases complications, Metabolic Diseases diagnosis, Rosacea blood, Rosacea complications
- Abstract
Recently, diverse hematologic parameters have been used as an indicator of the presence or severity of inflammatory and cardiovascular diseases. Our aim was to investigate the ratios of neutrophils to lymphocytes (NL), monocytes to high-density lipoprotein (HDL) cholesterol (MHC), and platelets to lymphocytes (PL) in patients with rosacea in comparison with the control group and determine whether there was a correlation between these ratios and metabolic disorders in patients with rosacea. We conducted a case-control study on 61 patients with rosacea and 60 healthy controls between January 2015 and January 2016 at the Dermatology Outpatient Clinic, Mugla, Turkey. Demographic data, biochemical parameters, hematologic parameters and ratios, the presence of metabolic syndrome (MS), and the presence of insulin resistance (IR) in the participants were recorded. Sixty one patients with rosacea (16 men, 45 women) and 60 controls (13 men, 47 women) were included in the study. The NL ratio, mean levels of low-density lipoprotein (LDL) and total cholesterol, triglyceride, C-reactive protein (CRP), systolic and diastolic blood pressures, and the presence of IR were significantly higher in patients with rosacea than in controls. In the rosacea group, the MHC ratio was significantly higher in patients with rosacea with IR and MS. Moreover, only the MHC ratio was an independent predictor of MS according to univariate logistic regression analysis. The cutoff value of MHC on admission for predicting MS in patients with rosacea was 0.013.The higher levels of NL ratio and IR in the rosacea group corroborate the previous studies demonstrating a high level of cardiovascular risk factors in patients with rosacea. The MHC ratio may be used as a simple and inexpensive method to predict metabolic disorders in patients with rosacea.
- Published
- 2017
44. Valdecoxib Recovers the Lipid Composition, Order and Dynamics in Colon Cancer Cell Lines Independent of COX-2 Expression: An ATR-FTIR Spectroscopy Study.
- Author
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Inan Genç A, Gok S, Banerjee S, and Severcan F
- Subjects
- Alkenes chemistry, Cell Line, Tumor, Cell Survival drug effects, Cluster Analysis, HT29 Cells, Humans, Alkenes analysis, Antineoplastic Agents pharmacology, Antineoplastic Agents toxicity, Colonic Neoplasms metabolism, Cyclooxygenase 2 Inhibitors pharmacology, Cyclooxygenase 2 Inhibitors toxicity, Isoxazoles pharmacology, Isoxazoles toxicity, Spectroscopy, Fourier Transform Infrared methods, Sulfonamides pharmacology, Sulfonamides toxicity
- Abstract
Prostanoids play an important role in a variety of physiological and pathophysiological processes including inflammation and cancer. The rate-limiting step in the prostanoid biosynthesis pathway is catalyzed by cyclooxygenases (COXs). Aberrant expression of the inducible isoform COX-2 plays a significant role in colon cancer initiation and progression. In this study, we have hypothesized that COX-2 specific inhibitors such as Valdecoxib (VLX), being highly hydrophobic, may alter biophysical properties of cellular lipids. In this study, COX-2 expressing (HT29) and COX-2 non-expressing (SW620) colon cancer cell lines were treated with VLX and examined using attenuated total reflection infrared spectroscopy. The results revealed that VLX treatment decreased lipid fluidity in the cells irrespective of COX-2 expression status and affected order parameters of the lipids in both cell lines. Cluster analysis also indicated that the spectral differences between the two cell lines are profound and could be successfully differentiated. Valdecoxib treatment could enhance the composition, order and dynamics of the lipids of colon cancer cells independently of its COX-2 inhibitory mechanism. Valdecoxib has therapeutic effects upon colon cancer, therefore it can be used as an adjuvant and/or chemopreventive agent for colon cancer.
- Published
- 2017
- Full Text
- View/download PDF
45. Apoptosis of colon cancer cells under the effect of geldanamycin derivate.
- Author
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Kosova F, Kasar Z, Tuglu I, Ozdal Kurt F, Gok S, Ari Z, and Imren T
- Subjects
- Colonic Neoplasms pathology, Humans, Tumor Cells, Cultured drug effects, Antineoplastic Agents pharmacology, Apoptosis drug effects, Benzoquinones pharmacology, Colonic Neoplasms drug therapy, Lactams, Macrocyclic pharmacology
- Abstract
Aim: The apoptotic effect of geldanamycin derivative may be important for the colorectal cancer therapy. The mechanisms of apoptosis require understanding of the behavior of colon cancer cell line Colo-205 which mimics colon adenocarcinoma. Therefore, the effect of IC50 dose of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on the colon cancer cells in vitro was studied for its anti-apoptotic activity., Method: Apoptotic ratio of the Colo-205 cells was determined after 17-AAG application with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and apoptosis related genes. Apoptosis signal path related key mitochondrial proteins, cytochrome c, bcl-2, caspase 9 and Apaf-1 expression were examined with RT-PCR method., Results: 17-AAG caused induction of cell death. Apoptotic related genes such as cytochrome-c, Apaf-1 and caspase-9 protein expressions were increased significantly (p < 0.05) and anti-apoptotic bcl-2 expression was decreased significantly (p < 0.05). Our results indicated that the application of 17-AAG on Colo-205 cells showed anticancer effect by the apoptosis due to alteration of apoptotic genes., Conclusion: The apoptotic effect of 17-AAG as an natural product for alternative medicine would be very important for the success and quality of life during the treatment of colon carcinoma with the combination of anticancer drugs (Tab. 1, Fig. 2, Ref. 32).
- Published
- 2017
- Full Text
- View/download PDF
46. One more health benefit of blood donation: reduces acute-phase reactants, oxidants and increases antioxidant capacity.
- Author
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Yunce M, Erdamar H, Bayram NA, and Gok S
- Subjects
- Adult, C-Reactive Protein metabolism, Female, Humans, Male, Nitric Oxide blood, Turkey epidemiology, Young Adult, Acute-Phase Proteins metabolism, Antioxidants metabolism, Blood Donors, Oxidants blood, Oxidative Stress physiology
- Abstract
Background: One of the most important problems in finding blood donors is the inadequacy of volunteer number. To overcome this problem, one of the solutions we suggest is innovating new health benefits of blood donation. The aim of the present study is to investigate the effects of blood donation on oxidative status markers and acute-phase reactants., Methods: A total of 96 healthy volunteers were recruited into the study. Blood samples were withdrawn 5 min before and 24 h after the blood donation. Serum nitric oxide, malondialdehyde levels, and activity of superoxide dismutase and myeloperoxidase were measured spectrophotometrically. Serum levels of high-sensitive C-reactive protein and pentraxin-3 as acute-phase reactants were measured by enzyme-linked immunosorbent assay kits., Results: We found statistically significant lower pentraxin-3 and high-sensitive C-reactive protein levels and higher superoxide dismutase activity and nitric oxide level 24 h after blood donation in serum of blood donor when compared with before blood donation., Conclusions: These findings suggest that blood donation affected oxidative status and acute-phase reactants in donors. Blood donation removes oxidants and decreases oxidative stress by elevating antioxidant enzyme such as superoxide dismutase. This is one more health benefit or reason why we should donate blood. Further large-scale studies should evaluate this mechanism and compare the same effect of wet cupping therapy.
- Published
- 2016
- Full Text
- View/download PDF
47. Bladder cancer diagnosis from bladder wash by Fourier transform infrared spectroscopy as a novel test for tumor recurrence.
- Author
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Gok S, Aydin OZ, Sural YS, Zorlu F, Bayol U, and Severcan F
- Subjects
- Cystoscopy, Humans, Reproducibility of Results, Neoplasm Recurrence, Local diagnostic imaging, Spectroscopy, Fourier Transform Infrared, Urinary Bladder Neoplasms diagnostic imaging
- Abstract
This study proposes Fourier Transform Infrared (FTIR) spectroscopy as a more sensitive, rapid, non-destructive and operator-independent analytical diagnostic method for bladder cancer recurrence from bladder wash than other routinely used urine cytology and cystoscopy methods. A total of 136 patients were recruited. FTIR spectroscopic experiments were carried out as a blind study, the classification results of which were then compared with those of cytology and cystoscopy. Firstly, 71 samples (n = 37; bladder cancer and n = 34; control) were studied with transmittance FTIR spectroscopy. After achieving successful differentiation of the groups, to develop a more rapid diagnostic tool and check the reproducibility of the results, the work was continued with different samples (n = 65 as n = 44; bladder cancer and n = 21; control), using the reflection mode (ATR) of FTIR spectroscopy by a different operator. The results revealed significant alterations in moleculer content in the cancer group. Based on the spectral differences, using transmittance FTIR spectroscopy coupled with chemometrics, the diseased group was successfully differentiated from the control. When only carcinoma group was taken into consideration a sensitivity value of 100% was achieved. Similar results were also obtained by ATR-FTIR spectroscopy. This study shows the power of infrared spectroscopy in the diagnosis of bladder cancer., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2016
- Full Text
- View/download PDF
48. Prediction of forelimb muscle EMGs from the corticospinal signals in rats.
- Author
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Gok S and Sahin M
- Subjects
- Animals, Axons physiology, Behavior, Animal, Databases, Factual, Principal Component Analysis, Rats, Spinal Cord, Electromyography, Forelimb physiology, Muscle, Skeletal physiology, Pyramidal Tracts physiology
- Abstract
To generate voluntary forearm movements, the information that is encoded in the activity of the cortical neurons has to travel through the spinal cord and activate the skeletal muscles. The axons carrying these signals are tightly bundled together in the descending tracts that control the spinal circuitry innervating the forearm muscles. In this paper, we show that corticospinal tract (CST) signals can be used to predict forearm electromyographic (EMG) activities that are recorded during an isometric-pull task. Rats were trained to pull on a metal bar through a window. A flexible-substrate multi-electrode array was chronically implanted into the dorsal column of the cervical spinal cord. Field potentials and multi-unit activities were recorded from the descending axons of the CST while the rat performed the task. Forelimb forces and EMG signals from a wrist extensor and a flexor, and the biceps and triceps were reconstructed using the neural signals in multiple sessions over three weeks. The regression coefficients found from the trial set were cross-validated on the other trials recorded on the same day. The maximum correlation coefficient between the actual and predicted signal was for the biceps (R=0.88). These results suggest the feasibility of an EMG-based spinal-cord-computer-interface (SCCI) for subjects with spinal cord injury.
- Published
- 2016
- Full Text
- View/download PDF
49. Risk Factors for Premature Hair Graying in Young Turkish Adults.
- Author
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Akin Belli A, Etgu F, Ozbas Gok S, Kara B, and Dogan G
- Subjects
- Adolescent, Adult, Cross-Sectional Studies, Female, Health Surveys, Humans, Male, Pigmentation Disorders etiology, Regression Analysis, Risk Factors, Turkey epidemiology, Young Adult, Hair Color, Pigmentation Disorders epidemiology
- Abstract
Background: Premature hair graying (PHG) is a common condition resulting in loss of self-esteem. Studies investigating PHG risk factors for both sexes with a large number of patients are scarce. We sought to investigate the socioclinical risk factors for PHG in young Turkish men and women and the differences between the sexes., Methods: A cross-sectional study was conducted in 1,119 participants who answered a survey about PHG and some socioclinical characteristics between February and July 2015. The number of gray hairs, onset age of hair graying, and family history of PHG were asked about, as well as demographic characteristics, anthropometric measures, body mass index, smoking, alcohol consumption, sports life, diet, medical history, educational status, occupation, marital status, monthly income, and Fitzpatrick skin type., Results: Of 1,119 participants, 315 (28.1%) had PHG and 804 did not. Maternal and paternal PHG, alcohol consumption, presence of chronic disease, educational status, hair loss, perceived stress scale (PSS) score, age, and height were significantly higher in subjects with PHG. Rates of maternal and paternal PHG were high in women with PHG, and the rate of paternal PHG was high in men with PHG. According to the multivariate ordinal regression analysis, PSS score, age, hair loss, and family history of PHG were correlated with the severity of PHG., Conclusion: PHG is closely related to factors causing oxidative stress, such as emotional stress, alcohol consumption, and chronic diseases in genetically predisposed men and women., (© 2016 Wiley Periodicals, Inc.)
- Published
- 2016
- Full Text
- View/download PDF
50. The relationship between rosacea and insulin resistance and metabolic syndrome.
- Author
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Akin Belli A, Ozbas Gok S, Akbaba G, Etgu F, and Dogan G
- Subjects
- Adult, Aged, Blood Glucose metabolism, Blood Pressure, C-Reactive Protein metabolism, Case-Control Studies, Cholesterol, LDL blood, Female, Humans, Male, Middle Aged, Triglycerides blood, Insulin Resistance physiology, Metabolic Syndrome epidemiology, Rosacea epidemiology, Rosacea physiopathology
- Abstract
Rosacea is a chronic inflammatory skin disease affecting the face. A positive correlation has been found between rosacea and cardiovascular diseases. We sought to investigate the relation between rosacea and metabolic syndrome (MS) and insulin resistance (IR). Between January and June 2015, a case-control study including 47 age-, gender-, and body mass index (BMI)-matched rosacea patients and 50 controls was conducted. Demographic data, clinical features of rosacea patients, anthropometric measures, laboratory findings, blood pressure levels, BMI, smoking history, alcohol consumption, sports life, family history of cardiovascular disease, and presence of MS and IR were recorded. Forty-seven rosacea patients (12 men and 35 women; age range: 35-68 years) and 50 controls (11 men and 39 women; age range: 38-78 years) were included in our study. Of 47 rosacea patients, 24 had erythematotelangiectatic type, 22 had papulopustular type, and one had phymatous type. Whereas the rate of IR was significantly higher in the rosacea group, there was no significant difference in the rate of MS between rosacea and the control group (p = 0.009 and p = 0.186, respectively). In addition, the rosacea group had significantly higher fasting blood glucose, total cholesterol, and systolic and diastolic blood pressure levels (p<0.05). Mean levels of LDL, triglyceride, total cholesterol and CRP were significantly higher than in the control group (p<0.05). Our findings suggest that there is a relationship between rosacea and IR and some parameters of cardiovascular risk factors. We recommend investigation of IR in rosacea patients.
- Published
- 2016
- Full Text
- View/download PDF
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