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1. Cloxacillin plus fosfomycin versus cloxacillin alone for methicillin-susceptible Staphylococcus aureus bacteremia: a randomized trial

Author

Grillo, Sara, Pujol, Miquel, Miró, Josep M., López-Contreras, Joaquín, Euba, Gorane, Gasch, Oriol, Boix-Palop, Lucia, Garcia-País, Maria José, Pérez-Rodríguez, Maria Teresa, Gomez-Zorrilla, Silvia, Oriol, Isabel, López-Cortés, Luis Eduardo, Pedro-Botet, Maria Luisa, San-Juan, Rafael, Aguado, José María, Gioia, Francesca, Iftimie, Simona, Morata, Laura, Jover-Sáenz, Alfredo, García-Pardo, Graciano, Loeches, Belén, Izquierdo-Cárdenas, Álvaro, Goikoetxea, Ane Josune, Gomila-Grange, Aina, Dietl, Beatriz, Berbel, Damaris, Videla, Sebastian, Hereu, Pilar, Padullés, Ariadna, Pallarès, Natalia, Tebé, Cristian, Cuervo, Guillermo, and Carratalà, Jordi

Published
2023
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2. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Sánchez, Fernando Fernández, de Lomas, José Mª García, Rosas, Gabriel, de la Torre Lima, Javier, Bereciartua, Elena, Vidal, María José Blanco, Blanco, Roberto, Boado, María Victoria, Lázaro, Marta Campaña, Crespo, Alejandro, Carrión, Laura Guio, Del Álamo Martínez de Lagos, Mikel, Ugarte, Gorane Euba, Goikoetxea, Ane Josune, Hierro, Marta Ibarrola, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, López, Mª Victoria García, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Rodríguez, Ignacio Álvarez, Galparsoro, Harkaitz Azkune, Boronat, Elisa Berritu, Odriozola, Mª Jesús Bustinduy, del Bosque Martín, Cristina, Echeverría, Tomás, Yarza, Alberto Eizaguirre, Fuentes, Ana, Goenaga, Miguel Ángel, del Río, Muskilda Goyeneche, Bauza, Ángela Granda, Iribarren, José Antonio, Urkola, Xabier Kortajarena, López, José Ignacio Pérez-Moreiras, Jiménez, Ainhoa Rengel, Reviejo, Karlos, Berbejillo, Alberto Sáez, Haza, Elou Sánchez, Alda, Rosa Sebastián, Ruiz, Itziar Solla, Ugartemendia, Irati Unamuno, Anza, Diego Vicente, Benito, Iñaki Villanueva, Arrieta, Mar Zabalo, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Bouzas, Alberto, Castelo, Brais, Cuenca, José, Gutiérrez, Laura, Ramos, Lucía, Mayo, María Rodríguez, Serrano, Joaquín Manuel, Regueiro, Dolores Sousa, Martínez, Francisco Javier, del Mar Alonso, Mª, Castro, Beatriz, Melian, Teresa Delgado, Sarabia, Javier Fernández, Rosado, Dácil García, González, Julia González, Lacalzada, Juan, de la Peña, Lissete Lorenzo, Ramírez, Alina Pérez, Arrondo, Pablo Prada, Moreno, Fermín Rodríguez, Ciezar, Antonio Plata, Iglesias, José Mª Reguera, Álvarez, Víctor Asensi, Costas, Carlos, de la Hera, Jesús, Suárez, Jonnathan Fernández, Fraile, Lisardo Iglesias, Arguero, Víctor León, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Esteban, Ángeles Rodríguez, García, Raquel Rodríguez, Asensio, Mauricio Telenti, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Cuervo, Guillermo, Falces, Carlos, Fernández-Pittol, Mariana J, Fita, Guillermina, Fuster, David, de la Mària, Cristina García, García-Pares, Delia, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Roque, Mercè, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Alonso, David, Alonso, Juan Carlos, Álvarez-Uría, Ana, Bermejo, Javier, Bouza, Emilio, Caballero, Gregorio Cuerpo, Montero, Antonia Delgado, Estévez, Agustín, Ribas, Ramón Fortuny, Gargallo, Esther, Leoni, Mª Eugenia García, Mansilla, Ana González, Moraga, Francisco Javier González, Ramallo, Víctor González, Hernández, Martha Kestler, Hualde, Amaia Mari, Machado, Marina, Marín, Mercedes, Martínez-Sellés, Manuel, Melero, Rosa, Muñoz, Patricia, Monzón, Diego, Olmedo, María, Pedraz, Álvaro, Pinilla, Blanca, Pinto, Ángel, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Sánchez-Pérez, Eduardo, Segado, Antonio, Toledo, Neera, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, de la Villa, Sofía, Antorrena, Isabel, Loeches, Belén, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Rosillo, Sandra, Balbín, Jesús Agüero, Fernández, Cristina Amado, Castillo, Carlos Armiñanzas, de las Revillas, Francisco Arnaiz, Belaustegui, Manuel Cobo, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Sampedro, Marta Fernández, García, Iván, Rico, Claudia González, Gutiérrez-Fernández, Laura, Gutiérrez-Cuadra, Manuel, Díez, José Gutiérrez, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Parra, Jorge Calderón, Cobo, Marta, Domínguez, Fernando, Pavía, Pablo García, Cruz, Ana Fernández, Ramos-Martínez, Antonio, Romero, Isabel Sánchez, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Stuart, Jorge Rodríguez-Roda, Ruiz, Soledad, Tenorio, Carmen Hidalgo, Sequera, Sergio, Delia, Manuel Almendro, Araji, Omar, Barquero, José Miguel, Jambrina, Román Calvo, de Cueto, Marina, Acebal, Juan Gálvez, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Lepe, José Antonio, López-Haldón, José, Luque-Márquez, Rafael, Marín, Guillermo, Ortiz-Carrellán, Antonio, Sánchez-Domínguez, Eladio, Alonso, Luis Javier, Azcárate, Pedro, Gutiérrez, José Manuel Azcona, Blanco, José Ramón, Armas, Estíbaliz Corral, García-Álvarez, Lara, Oteo, José Antonio, Membrilla, Antonio Barros, Iglesias, Antonino Ginel, Grillo, Sara, Petracca, Rubén Leta, López-Contreras, Joaquín, Martínez, María Alba Rivera, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Quiñonero, Amaia Aguirre, Miñambres, Ángela Alonso, Arana, Juan Carlos Gainzarain, de Alaiza Ortega, Sara González, Rodríguez, Miguel Ángel Morán, Rodríguez, Anai Moreno, de Zárate, Zuriñe Ortiz, Zapirain, José Joaquín Portu, de Adana Arroniz, Ester Sáez, Sánchez, Daisy Carolina Sorto, Antonio, Sánchez-Porto, Alejandro, Úbeda Iglesias, Leal, José Mª Arribas, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Pau, José Largo, Sepúlveda, Mª Antonia, Sierra, Pilar Toledano, Iqbal-Mirza, Sadaf Zafar, Alcolea, Eva Cascales, Yañez, Ivan Keituqwa, Martínez, Julián Navarro, Ballesta, Ana Peláez, Escobar, Eduardo Moreno, Monje, Alejandro Peña, Cabrera, Valme Sánchez, García, David Vinuesa, Asenjo, María Arrizabalaga, Luna, Carmen Cifuentes, Morcillo, Juana Núñez, Seco, Mª Cruz Pérez, Gelabert, Aroa Villoslada, Guallar, Carmen Aured, Abad, Nuria Fernández, Mangas, Pilar García, Adell, Marta Matamala, Ruiz, Mª Pilar Palacián, Porres, Juan Carlos, Vidal, Begoña Alcaraz, Del Amor Espín, María Jesús, Buendía, Francisco, Sánchez, Roberto Jiménez, Mármol, Rosario, Martínez, Francisco, Meseguer, Antonio, Pérez, Beatriz, Risco, Leticia, Saura, Zoser, Silva, Vanina, Villmarín, Mª Belén, Blanco, Mª Ángels Ribas, de Gopegui Bordes, Enrique Ruiz, Bonet, Laura Vidal, Borràs, Miquel Vives, Munera, Mª Carmen Bellón, Garaizabal, Elena Escribano, Martínez, Antonia Tercero, Luque, Juan Carlos Segura, Badía, Cristina, Palop, Lucía Boix, Xercavins, Mariona, Ibars, Sónia, Bosch, Xerach, Nebreda, Eloy Gómez, Herrera, Ibalia Horcajada, Gallego, Irene Menduiña, Pulido, Imanol, Santiago, Héctor Marrero, de Miguel Martínez, Isabel, Álamo, Elena Pisos, Sánchez, Daniel San Román, Pérez, Jorge Boan, Blanco, Eva Mª Aguilar, González, Mercedes Catalán, Peiretti, María Angélica Corres, Esteve, Andrea Eixerés, Pérez, Laura Domínguez, de Cossío Tejido, Santiago, Román, Francisco Galván, Robles, José Antonio García, Medrano, Francisco López, Gude, Mª Jesús López, Miguel, Mª Ángeles Orellana, Pilkington, Patrick, Ostalaza, Yolanda Revilla, Morales, Juan Ruiz, Solís, Sebastián Ruiz, Collado, Ana Sabín, Fernández, Marcos Sánchez, Rallo, Javier Solera, Martín, Jorge Solís, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Inmaculada, Ardanuy, Carmen, Berbel, Dámaris, Salado, José Carlos Sánchez, Alegre, Oriol, Majoral, Alejandro Ruiz, Sbraga, Fabrizio, Blasco, Arnau, Sánchez, Laura Gracia, Sánchez-Rodríguez, Iván, Aldamiz, Gonzalo, Álvarez, Beatriz, Palacios, Marina Bernal, Úbeda, Alfonso Cabello, Roblas, Ricardo Fernández, Hernández, Rafael, Martín, Victoria Andrea Hortigüela, Kallmeyer, Andrea, Kancev, Cristina Landaeta, Martín, Marta, Ruiz, Miguel Morante, Lobato, Miguel Ángel Navas, Pello, Ana María, Prieto, Laura, Mallebrera, Marta Tomás, Varela, Laura, de la Peña Triguero, Mireia, Cerón, Ruth Esther Figueroa, Gómez, Lara Ruiz, Ble, Mireia, Gallego, Juan Pablo Horcajada, Ginel, Antonio José, López, Inmaculada, Mas, Alexandra, Mestres, Antoni, Molina, Lluís, Serrat, Ramón, Ribas, Núria, Sánchez, Francisca, Silverio, Ana, Suárez, Marina, Sorlí, Luisa, Recasens, Lluís, Taurón, Manuel, Regueras, María Fernández, Vallejo, María Ángeles Mantecón, Rivera, José Ángel Pérez, Mata, Nuria Sánchez, Cano, Antonia Calvo, Olivares, Miguel Fajardo, Núñez, María Victoria Millán, Sanz, Agustín Muñoz, Herrera-Hidalgo, Laura, Alonso-Menchén, David, Luque-Marquez, Rafael, Fariñas, María Del Carmen, Miró, Jose Maria, Goenaga, Miguel Angel, Angulo-Lara, Basilio, and Boix-Palop, Lucia

Published
2023
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3. Trends in imported infections among migrants and travellers to Spain: a decade of analysis through the +Redivi network (2012–2022).

Author

Alkaissy, Yam, Serre-Delcor, Nuria, Vicente, Marta Arsuaga, Molina, Israel, Norman, Francesca F, Goikoetxea, Ane Josune, Dios, Begoña de, Torrús, Diego, Lorite, Miguel Nicolás Navarrete, Rodríguez-Guardado, Azucena, Lombide, Itxaso, Calabuig, Eva, Muriel, Alfonso, Perez-Molina, Jose A, and network, on behalf of +Redivi

Subjects
LATENT tuberculosis, CHIKUNGUNYA, CHAGAS' disease, TUBERCULOSIS, HUMAN migration patterns
Abstract

Background High-speed global travel, increased trade, world population growth, migration, urbanization and climate change have favoured the emergence and spread of pathogens. We aimed to analyse the evolution of imported infections in Spain during 2012–2022 and the potential impact of some of the abovementioned factors on differential morbidity patterns. Methods In this retrospective study (January 2012 to December 2022), we analysed data collected by the +Redivi network across 25 health centres. The network's standardised database records new cases of imported infections, including patient demographics, travel history, pre-travel advice and diagnostic information. To assess outcome rates over time and potential interactions, we constructed penalized weighted models to reduce the bias related to a low event rate and used weighted logistic regression for morbidity outcomes. Results We recorded 25 632 episodes, comprising 13 913 migrants, 4047 visiting friends and relatives (VFR) immigrants, 392 VFR travellers and 7280 travellers. Most immigrants came from South America (48.3%), Sub-Saharan Africa (28.5%), North Africa (6.6%), South Central Asia (5.4%) and Central America/Caribbean (5.3%). The most common regions visited by travellers were Sub-Saharan Africa (33.5%), South America (24.5%), Central America/Caribbean (13.5%), Southeast Asia (12%) and South Central Asia (10%). The proportion of diagnoses of malaria, strongyloidiasis and unspecified self-limiting febrile syndrome < 3 weeks remained unchanged during the study period. An increased frequency of diagnosis was reported for schistosomiasis, blastocystosis, giardiasis, dengue, diarrhoea, new cases of HIV, latent and pulmonary tuberculosis, whereas a decrease was reported for syphilis, chikungunya fever, Chagas disease and eosinophilia. We detected interactions between time and sex or type of participant across the different diagnoses. Conclusions Our study underscores the importance of epidemiological data in understanding infectious diseases dynamics among travellers and migrants, emphasizing how demographic shifts, migration trends and healthcare policies affect disease profiles. Comprehensive data play an essential role in enhancing public health policies and travel advice. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Herrera-Hidalgo, Laura, primary, Muñoz, Patricia, additional, Álvarez-Uría, Ana, additional, Alonso-Menchén, David, additional, Luque-Marquez, Rafael, additional, Gutiérrez-Carretero, Encarnación, additional, Fariñas, María Del Carmen, additional, Miró, Jose Maria, additional, Goenaga, Miguel Angel, additional, López-Cortés, Luis Eduardo, additional, Angulo-Lara, Basilio, additional, Boix-Palop, Lucia, additional, de Alarcón, Arístides, additional, Sánchez, Fernando Fernández, additional, de Lomas, José Mª García, additional, Rosas, Gabriel, additional, de la Torre Lima, Javier, additional, Bereciartua, Elena, additional, Vidal, María José Blanco, additional, Blanco, Roberto, additional, Boado, María Victoria, additional, Lázaro, Marta Campaña, additional, Crespo, Alejandro, additional, Carrión, Laura Guio, additional, Del Álamo Martínez de Lagos, Mikel, additional, Ugarte, Gorane Euba, additional, Goikoetxea, Ane Josune, additional, Hierro, Marta Ibarrola, additional, Iruretagoyena, José Ramón, additional, Zuazabal, Josu Irurzun, additional, López-Soria, Leire, additional, Montejo, Miguel, additional, Nieto, Javier, additional, Rodrigo, David, additional, Rodríguez, Regino, additional, Vitoria, Yolanda, additional, Voces, Roberto, additional, López, Mª Victoria García, additional, Georgieva, Radka Ivanova, additional, Ojeda, Guillermo, additional, Bailón, Isabel Rodríguez, additional, Morales, Josefa Ruiz, additional, Rodríguez, Ignacio Álvarez, additional, Galparsoro, Harkaitz Azkune, additional, Boronat, Elisa Berritu, additional, Odriozola, Mª Jesús Bustinduy, additional, del Bosque Martín, Cristina, additional, Echeverría, Tomás, additional, Yarza, Alberto Eizaguirre, additional, Fuentes, Ana, additional, Goenaga, Miguel Ángel, additional, del Río, Muskilda Goyeneche, additional, Bauza, Ángela Granda, additional, Iribarren, José Antonio, additional, Urkola, Xabier Kortajarena, additional, López, José Ignacio Pérez-Moreiras, additional, Jiménez, Ainhoa Rengel, additional, Reviejo, Karlos, additional, Berbejillo, Alberto Sáez, additional, Haza, Elou Sánchez, additional, Alda, Rosa Sebastián, additional, Ruiz, Itziar Solla, additional, Ugartemendia, Irati Unamuno, additional, Anza, Diego Vicente, additional, Benito, Iñaki Villanueva, additional, Arrieta, Mar Zabalo, additional, Carrasco, Rafael, additional, Climent, Vicente, additional, Llamas, Patricio, additional, Merino, Esperanza, additional, Plazas, Joaquín, additional, Reus, Sergio, additional, Bouzas, Alberto, additional, Castelo, Brais, additional, Cuenca, José, additional, Gutiérrez, Laura, additional, Ramos, Lucía, additional, Mayo, María Rodríguez, additional, Serrano, Joaquín Manuel, additional, Regueiro, Dolores Sousa, additional, Martínez, Francisco Javier, additional, del Mar Alonso, Mª, additional, Castro, Beatriz, additional, Melian, Teresa Delgado, additional, Sarabia, Javier Fernández, additional, Rosado, Dácil García, additional, González, Julia González, additional, Lacalzada, Juan, additional, de la Peña, Lissete Lorenzo, additional, Ramírez, Alina Pérez, additional, Arrondo, Pablo Prada, additional, Moreno, Fermín Rodríguez, additional, Ciezar, Antonio Plata, additional, Iglesias, José Mª Reguera, additional, Álvarez, Víctor Asensi, additional, Costas, Carlos, additional, de la Hera, Jesús, additional, Suárez, Jonnathan Fernández, additional, Fraile, Lisardo Iglesias, additional, Arguero, Víctor León, additional, Menéndez, José López, additional, Bajo, Pilar Mencia, additional, Morales, Carlos, additional, Torrico, Alfonso Moreno, additional, Palomo, Carmen, additional, Martínez, Begoña Paya, additional, Esteban, Ángeles Rodríguez, additional, García, Raquel Rodríguez, additional, Asensio, Mauricio Telenti, additional, Almela, Manuel, additional, Ambrosioni, Juan, additional, Azqueta, Manuel, additional, Brunet, Mercè, additional, Bodro, Marta, additional, Cartañá, Ramón, additional, Cuervo, Guillermo, additional, Falces, Carlos, additional, Fernández-Pittol, Mariana J, additional, Fita, Guillermina, additional, Fuster, David, additional, de la Mària, Cristina García, additional, García-Pares, Delia, additional, Hernández-Meneses, Marta, additional, Pérez, Jaume Llopis, additional, Marco, Francesc, additional, Miró, José M., additional, Moreno, Asunción, additional, Nicolás, David, additional, Ninot, Salvador, additional, Quintana, Eduardo, additional, Paré, Carlos, additional, Pereda, Daniel, additional, Pericás, Juan M., additional, Pomar, José L., additional, Ramírez, José, additional, Roque, Mercè, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Soy, Dolors, additional, Téllez, Adrián, additional, Tolosana, José M., additional, Vidal, Bárbara, additional, Vila, Jordi, additional, Adán, Iván, additional, Alonso, David, additional, Alonso, Juan Carlos, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Caballero, Gregorio Cuerpo, additional, Montero, Antonia Delgado, additional, Estévez, Agustín, additional, Ribas, Ramón Fortuny, additional, Gargallo, Esther, additional, Leoni, Mª Eugenia García, additional, Mansilla, Ana González, additional, Moraga, Francisco Javier González, additional, Ramallo, Víctor González, additional, Hernández, Martha Kestler, additional, Hualde, Amaia Mari, additional, Machado, Marina, additional, Marín, Mercedes, additional, Martínez-Sellés, Manuel, additional, Melero, Rosa, additional, Monzón, Diego, additional, Olmedo, María, additional, Pedraz, Álvaro, additional, Pinilla, Blanca, additional, Pinto, Ángel, additional, Rincón, Cristina, additional, Rodríguez-Abella, Hugo, additional, Rodríguez-Créixems, Marta, additional, Sánchez-Pérez, Eduardo, additional, Segado, Antonio, additional, Toledo, Neera, additional, Valerio, Maricela, additional, Vázquez, Pilar, additional, Moreno, Eduardo Verde, additional, de la Villa, Sofía, additional, Antorrena, Isabel, additional, Loeches, Belén, additional, Moreno, Mar, additional, Ramírez, Ulises, additional, Bastón, Verónica Rial, additional, Romero, María, additional, Rosillo, Sandra, additional, Balbín, Jesús Agüero, additional, Fernández, Cristina Amado, additional, Castillo, Carlos Armiñanzas, additional, de las Revillas, Francisco Arnaiz, additional, Belaustegui, Manuel Cobo, additional, Fariñas, María Carmen, additional, Fariñas-Álvarez, Concepción, additional, Sampedro, Marta Fernández, additional, García, Iván, additional, Rico, Claudia González, additional, Gutiérrez-Fernández, Laura, additional, Gutiérrez-Cuadra, Manuel, additional, Díez, José Gutiérrez, additional, Pajarón, Marcos, additional, Parra, José Antonio, additional, Teira, Ramón, additional, Zarauza, Jesús, additional, Parra, Jorge Calderón, additional, Cobo, Marta, additional, Domínguez, Fernando, additional, Pavía, Pablo García, additional, Cruz, Ana Fernández, additional, Ramos-Martínez, Antonio, additional, Romero, Isabel Sánchez, additional, Centella, Tomasa, additional, Hermida, José Manuel, additional, Moya, José Luis, additional, Martín-Dávila, Pilar, additional, Navas, Enrique, additional, Oliva, Enrique, additional, del Río, Alejandro, additional, Stuart, Jorge Rodríguez-Roda, additional, Ruiz, Soledad, additional, Tenorio, Carmen Hidalgo, additional, Sequera, Sergio, additional, Delia, Manuel Almendro, additional, Araji, Omar, additional, Barquero, José Miguel, additional, Jambrina, Román Calvo, additional, de Cueto, Marina, additional, Acebal, Juan Gálvez, additional, Méndez, Irene, additional, Morales, Isabel, additional, Lepe, José Antonio, additional, López-Haldón, José, additional, Luque-Márquez, Rafael, additional, Marín, Guillermo, additional, Ortiz-Carrellán, Antonio, additional, Sánchez-Domínguez, Eladio, additional, Alonso, Luis Javier, additional, Azcárate, Pedro, additional, Gutiérrez, José Manuel Azcona, additional, Blanco, José Ramón, additional, Armas, Estíbaliz Corral, additional, García-Álvarez, Lara, additional, Oteo, José Antonio, additional, Membrilla, Antonio Barros, additional, Iglesias, Antonino Ginel, additional, Grillo, Sara, additional, Petracca, Rubén Leta, additional, López-Contreras, Joaquín, additional, Martínez, María Alba Rivera, additional, Álvarez, M., additional, Fernández, A.L., additional, Martínez, Amparo, additional, Prieto, A., additional, Regueiro, Benito, additional, Tijeira, E., additional, Vega, Marino, additional, Quiñonero, Amaia Aguirre, additional, Miñambres, Ángela Alonso, additional, Arana, Juan Carlos Gainzarain, additional, de Alaiza Ortega, Sara González, additional, Rodríguez, Miguel Ángel Morán, additional, Rodríguez, Anai Moreno, additional, de Zárate, Zuriñe Ortiz, additional, Zapirain, José Joaquín Portu, additional, de Adana Arroniz, Ester Sáez, additional, Sánchez, Daisy Carolina Sorto, additional, Antonio, Sánchez-Porto, additional, Alejandro, Úbeda Iglesias, additional, Leal, José Mª Arribas, additional, Vázquez, Elisa García, additional, Torres, Alicia Hernández, additional, Blázquez, Ana, additional, de la Morena Valenzuela, Gonzalo, additional, Alonso, Ángel, additional, Aramburu, Javier, additional, Calvo, Felicitas Elena, additional, Tarabini-Castellani, Paola, additional, Gálvez, Eva Heredero, additional, Bellido, Carolina Maicas, additional, Pau, José Largo, additional, Sepúlveda, Mª Antonia, additional, Sierra, Pilar Toledano, additional, Iqbal-Mirza, Sadaf Zafar, additional, Alcolea, Eva Cascales, additional, Yañez, Ivan Keituqwa, additional, Martínez, Julián Navarro, additional, Ballesta, Ana Peláez, additional, Escobar, Eduardo Moreno, additional, Monje, Alejandro Peña, additional, Cabrera, Valme Sánchez, additional, García, David Vinuesa, additional, Asenjo, María Arrizabalaga, additional, Luna, Carmen Cifuentes, additional, Morcillo, Juana Núñez, additional, Seco, Mª Cruz Pérez, additional, Gelabert, Aroa Villoslada, additional, Guallar, Carmen Aured, additional, Abad, Nuria Fernández, additional, Mangas, Pilar García, additional, Adell, Marta Matamala, additional, Ruiz, Mª Pilar Palacián, additional, Porres, Juan Carlos, additional, Vidal, Begoña Alcaraz, additional, Del Amor Espín, María Jesús, additional, Buendía, Francisco, additional, Sánchez, Roberto Jiménez, additional, Mármol, Rosario, additional, Martínez, Francisco, additional, Meseguer, Antonio, additional, Pérez, Beatriz, additional, Risco, Leticia, additional, Saura, Zoser, additional, Silva, Vanina, additional, Villmarín, Mª Belén, additional, Blanco, Mª Ángels Ribas, additional, de Gopegui Bordes, Enrique Ruiz, additional, Bonet, Laura Vidal, additional, Borràs, Miquel Vives, additional, Munera, Mª Carmen Bellón, additional, Garaizabal, Elena Escribano, additional, Martínez, Antonia Tercero, additional, Luque, Juan Carlos Segura, additional, Badía, Cristina, additional, Palop, Lucía Boix, additional, Xercavins, Mariona, additional, Ibars, Sónia, additional, Bosch, Xerach, additional, Nebreda, Eloy Gómez, additional, Herrera, Ibalia Horcajada, additional, Gallego, Irene Menduiña, additional, Pulido, Imanol, additional, Santiago, Héctor Marrero, additional, de Miguel Martínez, Isabel, additional, Álamo, Elena Pisos, additional, Sánchez, Daniel San Román, additional, Pérez, Jorge Boan, additional, Blanco, Eva Mª Aguilar, additional, González, Mercedes Catalán, additional, Peiretti, María Angélica Corres, additional, Esteve, Andrea Eixerés, additional, Pérez, Laura Domínguez, additional, de Cossío Tejido, Santiago, additional, Román, Francisco Galván, additional, Robles, José Antonio García, additional, Medrano, Francisco López, additional, Gude, Mª Jesús López, additional, Miguel, Mª Ángeles Orellana, additional, Pilkington, Patrick, additional, Ostalaza, Yolanda Revilla, additional, Morales, Juan Ruiz, additional, Solís, Sebastián Ruiz, additional, Collado, Ana Sabín, additional, Fernández, Marcos Sánchez, additional, Rallo, Javier Solera, additional, Martín, Jorge Solís, additional, Escrihuela-Vidal, Francesc, additional, Carratalà, Jordi, additional, Grau, Inmaculada, additional, Ardanuy, Carmen, additional, Berbel, Dámaris, additional, Salado, José Carlos Sánchez, additional, Alegre, Oriol, additional, Majoral, Alejandro Ruiz, additional, Sbraga, Fabrizio, additional, Blasco, Arnau, additional, Sánchez, Laura Gracia, additional, Sánchez-Rodríguez, Iván, additional, Aldamiz, Gonzalo, additional, Álvarez, Beatriz, additional, Palacios, Marina Bernal, additional, Úbeda, Alfonso Cabello, additional, Roblas, Ricardo Fernández, additional, Hernández, Rafael, additional, Martín, Victoria Andrea Hortigüela, additional, Kallmeyer, Andrea, additional, Kancev, Cristina Landaeta, additional, Martín, Marta, additional, Ruiz, Miguel Morante, additional, Lobato, Miguel Ángel Navas, additional, Pello, Ana María, additional, Prieto, Laura, additional, Mallebrera, Marta Tomás, additional, Varela, Laura, additional, de la Peña Triguero, Mireia, additional, Cerón, Ruth Esther Figueroa, additional, Gómez, Lara Ruiz, additional, Ble, Mireia, additional, Gallego, Juan Pablo Horcajada, additional, Ginel, Antonio José, additional, López, Inmaculada, additional, Mas, Alexandra, additional, Mestres, Antoni, additional, Molina, Lluís, additional, Serrat, Ramón, additional, Ribas, Núria, additional, Sánchez, Francisca, additional, Silverio, Ana, additional, Suárez, Marina, additional, Sorlí, Luisa, additional, Recasens, Lluís, additional, Taurón, Manuel, additional, Regueras, María Fernández, additional, Vallejo, María Ángeles Mantecón, additional, Rivera, José Ángel Pérez, additional, Mata, Nuria Sánchez, additional, Cano, Antonia Calvo, additional, Olivares, Miguel Fajardo, additional, Núñez, María Victoria Millán, additional, and Sanz, Agustín Muñoz, additional

Published
2023
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5. Cloxacillin plus fosfomycin versus cloxacillin alone for methicillin-susceptible Staphylococcus aureus bacteremia: a randomized trial

Author

Ministerio de Sanidad (España), Instituto de Salud Carlos III, Laboratorios ERN, European Commission, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Generalitat de Catalunya, Grillo, Sara, Pujol, Miquel, Miró, Josep M., López-Contreras, Joaquín, Euba, Gorane, Gasch, Oriol, Boix-Palop, Lucía, García-País, María José, Pérez-Rodríguez, María Teresa, Gómez-Zorrilla, Silvia, Oriol, Isabel, López-Cortés, Luis Eduardo, Pedro-Botet, María Luisa, San Juan, Rafael, Aguado, José María, Gioia, Francesca, Iftimie, Simona, Morata, Laura, Jover-Sáenz, Alfredo, García-Pardo, Graciano, Loeches, Belén, Izquierdo-Cárdenas, Álvaro, Goikoetxea, Ane Josune, Gomila-Grange, Aina, Dietl, Beatriz, Berbel, Damaris, Videla, Sebastian, Hereu, Pilar, Padullés, Ariadna, Pallarès, Natalia, Tebé, Cristian, Cuervo, Guillermo, Carratalà, Jordi, SAFO study group, Cueto, Marina de, Moreno-Mellado, Elisa, Ministerio de Sanidad (España), Instituto de Salud Carlos III, Laboratorios ERN, European Commission, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Generalitat de Catalunya, Grillo, Sara, Pujol, Miquel, Miró, Josep M., López-Contreras, Joaquín, Euba, Gorane, Gasch, Oriol, Boix-Palop, Lucía, García-País, María José, Pérez-Rodríguez, María Teresa, Gómez-Zorrilla, Silvia, Oriol, Isabel, López-Cortés, Luis Eduardo, Pedro-Botet, María Luisa, San Juan, Rafael, Aguado, José María, Gioia, Francesca, Iftimie, Simona, Morata, Laura, Jover-Sáenz, Alfredo, García-Pardo, Graciano, Loeches, Belén, Izquierdo-Cárdenas, Álvaro, Goikoetxea, Ane Josune, Gomila-Grange, Aina, Dietl, Beatriz, Berbel, Damaris, Videla, Sebastian, Hereu, Pilar, Padullés, Ariadna, Pallarès, Natalia, Tebé, Cristian, Cuervo, Guillermo, Carratalà, Jordi, SAFO study group, Cueto, Marina de, and Moreno-Mellado, Elisa

Abstract

Treatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. We assessed whether cloxacillin plus fosfomycin achieves better treatment success than cloxacillin alone in hospitalized adults with MSSA bacteremia. We conducted a multicenter, open-label, phase III–IV superiority randomized clinical trial. We randomly assigned patients (1:1) to receive 2 g of intravenous cloxacillin alone every 4 h or with 3 g of intravenous fosfomycin every 6 h for the initial 7 days. The primary endpoint was treatment success at day 7, a composite endpoint with the following criteria: patient alive, stable or with improved quick Sequential Organ Failure Assessment score, afebrile and with negative blood cultures for MSSA, adjudicated by an independent committee blinded to treatment allocation. We randomized 215 patients, of whom 105 received cloxacillin plus fosfomycin and 110 received cloxacillin alone. We analyzed the primary endpoint with the intention-to-treat approach in 214 patients who received at least 1 day of treatment. Treatment success at day 7 after randomization was achieved in 83 (79.8%) of 104 patients receiving combination treatment versus 82 (74.5%) of 110 patients receiving monotherapy (risk difference 5.3%; 95% confidence interval (CI), –5.95–16.48). Secondary endpoints, including mortality and adverse events, were similar in the two groups except for persistent bacteremia at day 3, which was less common in the combination arm. In a prespecified interim analysis, the independent committee recommended stopping recruitment for futility prior to meeting the planned randomization of 366 patients. Cloxacillin plus fosfomycin did not achieve better treatment success at day 7 of therapy than cloxacillin alone in MSSA bacteremia. Further trials should consider the intrinsic heterogeneity of the infection by using a more personalized approach. ClinicalTrials.gov registration: NCT03959345.

Published
2023

6. Effectiveness and Safety of a Structured De-Escalation from Antipseudomonal Β-Lactams in Bloodstream Infections Due to Enterobacterales: A Multicentre Randomised Clinical Trial (SIMPLIFY)

Author

López-Cortés, Luis Eduardo, primary, Delgado-Valverde, Mercedes, additional, Moreno Mellado, Elisa, additional, Goikoetxea, Ane Josune, additional, Guio Carrión, Laura, additional, Blanco Vidal, Maria José, additional, López Soria, Leyre Mónica, additional, Pérez Rodríguez, Maria Teresa, additional, Martínez Lamas, Lucía, additional, Arnaiz de las Revillas, Francisco v., additional, Armiñanzas, Carlos, additional, Ruiz de Alegría-Puig, Carlos, additional, Jiménez Aguilar, Patricia, additional, Martínez-Rubio, María del Carmen, additional, Sáez-Bejar, Carmen, additional, de las Cuevas, Carmen, additional, Martín-Aspas, Andrés, additional, Galán, Fátima, additional, Yuste, José Ramón, additional, Leiva-León, José, additional, Bou, Germán, additional, Capón González, Patricia, additional, Boix-Palop, Lucía, additional, Xercavins-Valls, Mariona, additional, Goenaga-Sánchez, Miguel Ángel, additional, Vicente Anza, Diego, additional, Castón, Juan José, additional, Recio, Manuel, additional, Merino, Esperanza, additional, Rodriguez Díaz, Juan Carlos, additional, Loeches, Belen, additional, Cuervo, Guillermo, additional, Guerra Glaso, José Manuel, additional, Plata-Ciézar, Antonio, additional, Pérez Cortés, Salvador, additional, López Mato, Pablo, additional, Sierra Monzón, Jose Luis, additional, Rosso-Fernández, Clara, additional, Bravo-Ferrer, Jose M., additional, Retamar Gentil, Pilar, additional, and Rodríguez-Baño, Jesús , additional

Published
2023
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7. Tenofovir Disoproxil Fumarate/Emtricitabine and Baricitinib for Patients at High Risk of Severe Coronavirus Disease 2019: The PANCOVID Randomized Clinical Trial.

Author

Montejano, Rocío, de la Calle-Prieto, Fernando, Velasco, María, Guijarro, Carlos, Queiruga-Parada, Javier, Jiménez-González, María, González-Ruano, Patricia, Martínez, Patricia, Goikoetxea, Ane Josune, Ibarrola, Marta, Ciudad, Marianela, Gutiérrez, Ángela, Torralba, Miguel, Díaz-Brasero, Ana, Ryan, Pablo, Marcelo, Cristina, Díez, Cristina, Ibarra, Sofía, Merino, Esperanza, and Estrada, Vicente

Subjects
RELATIVE medical risk, DISEASE progression, COVID-19, COMBINATION drug therapy, CONFIDENCE intervals, INFLAMMATION, TIME, SEVERITY of illness index, JANUS kinases, TREATMENT effectiveness, RANDOMIZED controlled trials, EMTRICITABINE-tenofovir, HOSPITAL care, DESCRIPTIVE statistics, RESEARCH funding, NEUROTRANSMITTER uptake inhibitors, HYPOXEMIA, EVALUATION
Abstract

Background This study was designed to evaluate if patients with high risk for severe coronavirus disease 2019 (COVID-19) would benefit from treatment with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) followed by baricitinib in case of hypoxemia and systemic inflammation. Methods PANCOVID is an open-label, double-randomized, phase 3 pragmatic clinical trial including adults with symptomatic COVID-19 with ≥2 comorbidities or aged ≥60 years and was conducted between 10 October 2020 and 23 September 2021. In the first randomization, patients received TDF/FTC or no TDF/FTC. In the second randomization, patients with room air oxygen saturation <95% and at least 1 increased inflammatory biomarker received baricitinib plus dexamethasone or dexamethasone alone. The primary endpoint was 28-day mortality. Main secondary endpoint was 28-day disease progression or critical care unit admission or mortality. The trial was stopped before reaching planned sample size due to the decrease in the number of cases and a mortality rate substantially lower than expected. Results Of the 355 included participants, 97% were hospitalized at baseline. Overall, 28-day mortality was 3.1%. The 28-day mortality relative risk (RR) for participants treated with TDF/FTC was 1.76 (95% confidence interval [CI],.52–5.91; P =.379); it was 0.42 (95% CI,.11–1.59; P =.201) for those treated with baricitinib. The 28-day RR for the main secondary combined endpoint for participants treated with TDF/FTC was 0.95 (95% CI,.66–1.40; P =.774); it was 0.90 (95% CI,.61–1.33; P =.687) for those treated with baricitinib. Conclusions Our results do not suggest a beneficial effect of TDF/FTC; nevertheless, they are compatible with the beneficial effect of baricitinib already established by other clinical trials. Clinical Trials Registration EudraCT: 2020-001156-18. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Mural Endocarditis: The GAMES Registry Series and Review of the Literature

Author

Gutiérrez-Villanueva, Andrea, Muñoz, Patricia, Delgado-Montero, Antonia, Olmedo-Samperio, María, de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Zarauza, Jesús, García i Pares, Delia, Goenaga, Miguel Ángel, Ojeda-Burgos, Guillermo, Goikoetxea-Agirre, Ane Josune, Reguera-Iglesias, José Mª, Ramos, Antonio, Fernández-Cruz, Ana, Fernández-Sánchez, Fernando, García de Lomas, José Mª, Rosas, Gabriel, de la Torre Lima, Javier, Bereciartua, Elena, Blanco-Vidal, María José, Blanco, Roberto, Boado, María Victoria, Campaña-Lázaro, Marta, Crespo, Alejandro, Guio-Carrión, Laura, del Álamo Martínez-Lagos, Mikel, Euba-Ugarte, Gorane, Goikoetxea, Ane Josune, Ibarrola-Hierro, Marta, Iruretagoyena, José Ramón, Irurzun-Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García-López, Mª Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Rodríguez-Bailón, Isabel, Ruiz-Morales, Josefa, Azkune-Galparsoro, Harkaitz, Berritu-Boronat, Elisa, Bustinduy-Odriozola, Mª Jesús, del Bosque Martín, Cristina, Echeverría, Tomás, Eizaguirre-Yarza, Alberto, Fuentes, Ana, Goyeneche del Río, Muskilda, Granda-Bauza, Ángela, Iribarren, José Antonio, Kortajarena-Urkola, Xabier, Pérez-Moreiras López, José Ignacio, Rengel-Jiménez, Ainhoa, Reviejo, Karlos, Sáez-Berbejillo, Alberto, Sánchez-Haza, Elou, Sebastián-Alda, Rosa, Solla-Ruiz, Itziar, Unamuno-Ugartemendia, Irati, Anza, Diego Vicente, Villanueva-Benito, Iñaki, Zabalo-Arrieta, Mar, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez-Rey, Enrique, Rodríguez-Mayo, María, Sánchez, Efrén, Sousa-Regueiro, Dolores, Martínez, Francisco Javier, del Mar Alonso, null, Castro, Beatriz, Delgado-Melian, Teresa, Fernández-Sarabia, Javier, García-Rosado, Dácil, González-González, Julia, Lacalzada, Juan, Lorenzo de la Peña, Lissete, Pérez-Ramírez, Alina, Prada-Arrondo, Pablo, Rodríguez-Moreno, Fermín, Plata-Ciezar, Antonio, Asensi-Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández-Suárez, Jonnathan, Iglesias-Fraile, Lisardo, León-Arguero, Víctor, López-Menéndez, José, Mencia-Bajo, Pilar, Morales, Carlos, Moreno-Torrico, Alfonso, Palomo, Carmen, Paya-Martínez, Begoña, Rodríguez-Esteban, Ángeles, Rodríguez-García, Raquel, Telenti-Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis-Pérez, Jaume, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Alonso, Juan Carlos, Álvarez-Uría, Ana, Bermejo, Javier, Bouza, Emilio, Cuerpo-Caballero, Gregorio, González-Mansilla, Ana, García-Leoni, Mª Eugenia, Gargallo, Esther, González-Ramallo, Víctor, Kestler-Hernández, Martha, Hualde, Amaia Mari, Machado, Marina, Marín, Mercedes, Martínez-Sellés, Manuel, Olmedo, María, Pedraz, Álvaro, Pinilla, Blanca, Pinto, Ángel, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Segado, Antonio, Toledo, Neera, Valerio, Maricela, Vázquez, Pilar, Verde-Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Moreno, Mar, Ramírez, Ulises, Rial-Bastón, Verónica, Romero, María, Rosillo, Sandra, Agüero-Balbín, Jesús, Amado, Cristina, Armiñanzas-Castillo, Carlos, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Fernández-Sampedro, Marta, García, Iván, González-Rico, Claudia, Gutierrez-Fernandez, Laura, Gutiérrez-Cuadra, Manuel, Gutiérrez-Díez, José, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Calderón-Parra, Jorge, Cobo, Marta, Domínguez, Fernando, García-Pavía, Pablo, Ramos-Martínez, Antonio, Sánchez-Romero, Isabel, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Rodríguez-Roda Stuart, Jorge, Ruiz, Soledad, Hidalgo-Tenorio, Carmen, Almendro-Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo-Jambrina, Román, de Cueto, Marina, Gálvez-Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, Lepe, José Antonio, López-Haldón, José, Luque-Márquez, Rafael, Marín, Guillermo, Ortiz-Carrellán, Antonio, Sánchez-Domínguez, Eladio, Alonso, Luis Javier, Azcárate, Pedro, Azcona-Gutiérrez, José Manuel, Blanco, José Ramón, Cabrera-Villegas, Antonio, García-Álvarez, Lara, García-García, Concepción, Oteo, José Antonio, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, null, Fernández, null, Martínez, Amparo, Prieto, null, Regueiro, Benito, Tijeira, null, Vega, Marino, Canut-Blasco, Andrés, Mollar, José Cordo, Gainzarain-Arana, Juan Carlos, García-Uriarte, Oscar, Martín-López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi-Matos, José Antonio, Sánchez-Porto, Antonio, Úbeda-Iglesias, Alejandro, Arribas-Leal, José Mª, García-Vázquez, Elisa, Hernández-Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno-Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero-Gálvez, Eva, Maicas-Bellido, Carolina, Largo-Pau, José, Sepúlveda, Mª Antonia, Toledano-Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales-Alcolea, Eva, Keituqwa-Yañez, Ivan, Navarro-Martínez, Julián, Peláez-Ballesta, Ana, Moreno-Escobar, Eduardo, Peña-Monje, Alejandro, Sánchez-Cabrera, Valme, Vinuesa-García, David, Arrizabalaga-Asenjo, María, Cifuentes-Luna, Carmen, Núñez-Morcillo, Juana, Pérez-Seco, Mª Cruz, Villoslada-Gelabert, Aroa, Aured-Guallar, Carmen, Fernández-Abad, Nuria, García-Mangas, Pilar, Matamala-Adell, Marta, Palacián-Ruiz, Mª Pilar, Porres, Juan Carlos, Alcaraz-Vidal, Begoña, Cobos-Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner-Caro, José Antonio, Jiménez-Sánchez, Roberto, Jimeno-Almazán, Amaya, Ortín-Freire, Alejandro, Viqueira-González, Monserrat, Pericás-Ramis, Pere, Ribas-Blanco, Mª Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal-Bonet, Laura, Bellón-Munera, Mª Carmen, Escribano-Garaizabal, Elena, Tercero-Martínez, Antonia, Segura-Luque, Juan Carlos, Badía, Cristina, Boix-Palop, Lucía, Xercavins, Mariona, Ibars, Sónia, Bosch, Xerach, Gómez-Nebreda, Eloy, Horcajada-Herrera, Ibalia, Menduiña-Gallego, Irene, Pulido, Imanol, Marrero-Santiago, Héctor, de Miguel Martínez, Isabel, Pisos-Álamo, Elena, Aguilar-Blanco, Eva Mª, Catalán-González, Mercedes, Corres-Peiretti, María Angélica, Eixerés-Esteve, Andrea, Domínguez-Pérez, Laura, de Cossío Tejido, Santiago, Galván-Román, Francisco, García-Robles, José Antonio, López-Medrano, Francisco, López-Gude, Mª Jesús, Orellana-Miguel, Mª Ángeles, Pilkington, Patrick, Revilla-Ostalaza, Yolanda, Morales, Juan Ruiz, Ruiz-Solís, Sebastián, Collado, Ana Sabín, Sánchez-Fernández, Marcos, Rallo, Javier Solera, Martín, Jorge Solís, Cuervo, Guillermo, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Inmaculada, Grillo, Sara, Ardanuy, Carmen, Berbel, Dámaris, Sánchez-Salado, José Carlos, Alegre, Oriol, Ruiz-Majoral, Alejandro, Sbraga, Fabrizio, Blasco, Arnau, Sánchez, Laura Gracia, Sánchez-Rodríguez, Iván, Álvarez, Beatriz, Cabello-Úbeda, Alfonso, Fernández-Roblas, Ricardo, Navas-Lobato, Miguel Ángel, Pello, Ana María, de la Peña Triguero, Mireia, Figueroa-Cerón, Ruth Esther, Ruiz-Gómez, Lara, Ble, Mireia, Horcajada-Gallego, Juan Pablo, Ginel, Antonio José, López, Inmaculada, Mas, Alexandra, Mestres, Antoni, Molina, Lluís, Serrat, Ramón, Ribas, Núria, Sánchez, Francisca, Silverio, Ana, Suárez, Marina, Sorlí, Luisa, Recasens, Lluís, Taurón, Manuel, 0000-0003-1189-1120, and Universidad de Cantabria

Subjects
Microbiology (medical), medicine.medical_specialty, medicine.medical_treatment, Charlson index, Infections, Hospital patients, Mural, Internal medicine, medicine, Endocarditis, Malalts hospitalitzats, business.industry, Brief Report, medicine.disease, Infeccions, Transplantation, Catheter, Non-valvular endocarditis, Infectious Diseases, Infective endocarditis, Etiology, Hemodialysis, Complication, business, human activities
Abstract

Spanish Collaboration on Endocarditis—Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)., [Introduction] Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis., [Methods] Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series., [Results] Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device-associated IE (DIE), patients with MIE were younger (median age 59 years, p, [Conclusion] MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs.

Published
2021

9. Cloxacillin plus fosfomycin versus cloxacillin alone for methicillin-susceptible Staphylococcusaureusbacteremia: a randomized trial

Author

Grillo, Sara, Pujol, Miquel, Miró, Josep M., López-Contreras, Joaquín, Euba, Gorane, Gasch, Oriol, Boix-Palop, Lucia, Garcia-País, Maria José, Pérez-Rodríguez, Maria Teresa, Gomez-Zorrilla, Silvia, Oriol, Isabel, López-Cortés, Luis Eduardo, Pedro-Botet, Maria Luisa, San-Juan, Rafael, Aguado, José María, Gioia, Francesca, Iftimie, Simona, Morata, Laura, Jover-Sáenz, Alfredo, García-Pardo, Graciano, Loeches, Belén, Izquierdo-Cárdenas, Álvaro, Goikoetxea, Ane Josune, Gomila-Grange, Aina, Dietl, Beatriz, Berbel, Damaris, Videla, Sebastian, Hereu, Pilar, Padullés, Ariadna, Pallarès, Natalia, Tebé, Cristian, Cuervo, Guillermo, and Carratalà, Jordi

Abstract

Treatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcusaureus(MSSA) bacteremia. We assessed whether cloxacillin plus fosfomycin achieves better treatment success than cloxacillin alone in hospitalized adults with MSSA bacteremia. We conducted a multicenter, open-label, phase III–IV superiority randomized clinical trial. We randomly assigned patients (1:1) to receive 2 g of intravenous cloxacillin alone every 4 h or with 3 g of intravenous fosfomycin every 6 h for the initial 7 days. The primary endpoint was treatment success at day 7, a composite endpoint with the following criteria: patient alive, stable or with improved quick Sequential Organ Failure Assessment score, afebrile and with negative blood cultures for MSSA, adjudicated by an independent committee blinded to treatment allocation. We randomized 215 patients, of whom 105 received cloxacillin plus fosfomycin and 110 received cloxacillin alone. We analyzed the primary endpoint with the intention-to-treat approach in 214 patients who received at least 1 day of treatment. Treatment success at day 7 after randomization was achieved in 83 (79.8%) of 104 patients receiving combination treatment versus 82 (74.5%) of 110 patients receiving monotherapy (risk difference 5.3%; 95% confidence interval (CI), –5.95–16.48). Secondary endpoints, including mortality and adverse events, were similar in the two groups except for persistent bacteremia at day 3, which was less common in the combination arm. In a prespecified interim analysis, the independent committee recommended stopping recruitment for futility prior to meeting the planned randomization of 366 patients. Cloxacillin plus fosfomycin did not achieve better treatment success at day 7 of therapy than cloxacillin alone in MSSA bacteremia. Further trials should consider the intrinsic heterogeneity of the infection by using a more personalized approach. ClinicalTrials.gov registration: NCT03959345.

Published
2023
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10. 72. Remdesivir vs Standard Care in Patients with Moderate covid-19

Author

Marty, Francisco M, primary, Malhotra, Prashant, additional, Gottlieb, Robert L, additional, Tashima, Karen T, additional, Galli, Massimo, additional, Chai, Louis Yi Ann, additional, SenGupta, Devi, additional, Hyland, Robert H, additional, Wang, Hongyuan, additional, Zhong, Lijie, additional, Cao, Huyen, additional, Chokkalingam, Anand, additional, Osinusi, Anu, additional, Brainard, Diana M, additional, Brown, Michael, additional, Goikoetxea, Ane Josune, additional, Jain, Mamta, additional, Hui, David Shu Cheong, additional, Bernasconi, Enos, additional, and Spinner, Christoph, additional

Published
2020
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11. Clinicoepidemiological characteristics of viral hepatitis in migrants and travellers of the +Redivi network

Author

Henriquez-Camacho, Cesar, primary, Serre, Núria, additional, Norman, Francesca, additional, Sánchez-Montalvá, Adrián, additional, Torrús, Diego, additional, Goikoetxea, Ane Josune, additional, Herrero-Martínez, Juan María, additional, Ruiz-Giardín, José Manuel, additional, Treviño, Begoña, additional, Monge-Maillo, Begoña, additional, Molina, Israel, additional, Rodríguez, Azucena, additional, García, Magdalena, additional, López-Vélez, Rogelio, additional, Pérez-Molina, José A., additional, Aguilera, Paloma, additional, Serrano, María Martínez, additional, Rodriguez, Magdalena García, additional, Menendez, Marta Díaz, additional, Meije, Yolanda, additional, Martínez-Montauti, Joaquim, additional, Sanz, Xavier, additional, Tenza, Isabel Pacheco, additional, Cuello, Inmaculada Gonzalez, additional, López, Belén Martínez, additional, LLenas, Jara, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Romero, Mónica, additional, Wilkman-Jorgensen, Philip, additional, Ramos Rincón, José Manuel, additional, Malmierca, Eduardo, additional, Perez-Ayala, Ana, additional, Herrero, Juan María, additional, Lizasoain, Manuel, additional, Rojo, Pablo, additional, Matarranz, Mariano, additional, Zarco, Carlos, additional, Rodriguez-Guardado, Azucena, additional, Suárez, Jonathan Fernández, additional, Boga Ribeiro, Jose Antonio, additional, Aguirre, Josune Goikoetxea, additional, Zubero Sulibarría, Miren Zuriñe, additional, Ruiz Giardin, José Manuel, additional, Sanmartín López, Juan Victor, additional, Arribas, María Velasco, additional, Muñoz, Eva Calabuig, additional, Ribas, Ana Mena, additional, Vera, María Peñaranda, additional, Montalvá, Adrián Sánchez, additional, Salvador, Fernando, additional, Dominguez, Ángel, additional, Treviño-Maruri, Begoña, additional, Delcor, Nuria Serre, additional, Soriano-Arandes, Antonio, additional, Ciruelo, Diana Pou, additional, and Bocanegra, Cristina, additional

Published
2019
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12. Ceftaroline for bloodstream infections caused by methicillin-resistant Staphylococcus aureus: a multicentre retrospective cohort study.

Author

De La Villa S, Escrihuela-Vidal F, Fernández-Hidalgo N, Escudero-Sánchez R, Cabezón I, Boix-Palop L, Díaz-Pollán B, Goikoetxea AJ, García-País MJ, Pérez-Rodríguez MT, Crespo Á, Buzón-Martín L, Sanz-Peláez O, Ramos-Merino L, Silvante F, and Muñoz P

Abstract

Objectives: To evaluate the effectiveness of ceftaroline vs. vancomycin or daptomycin in the treatment of methicillin-resistant Staphylococcus aureus bloodstream infections (MRSA-BSIs)., Methods: This multicentre retrospective study conducted in 15 Spanish hospitals, included data from the first MRSA-BSIs of adult patients between January-2019 and December-2022. The ceftaroline group included patients who received ceftaroline for ≥72h within the first week of BSI onset; the standard of care (SOC) group included patients who received vancomycin or daptomycin ≥72h after BSI onset. Primary outcome was 30-day all-cause mortality; secondary outcomes included 90-day mortality and incidence of adverse events (AEs). Propensity-score (PS) matching and Cox proportional-hazards analyses were performed., Results: A total of 429 MRSA-BSIs were included: 133 in the ceftaroline group and 296 in the SOC group. More patients in the ceftaroline group had a SOFA score>2 (51.1% vs. 36.5%; p<0.01), complicated-BSI (66.2% vs. 42.2%; p<0.01), infective endocarditis (18.8% vs. 6.4%; p<0.01) and prescribed in combination treatment (65.4% vs. 11.5%; p<0.01), with no statistically significant differences in 30-day mortality: 23.3% ceftaroline (95%CI 16.1%-30.5%) vs. 16.2% SOC (95%CI 12.0%-20.4%), p=0.08. There were no statistically significant differences in 90-day mortality (33.1% ceftaroline vs. 26.7% SOC; p=0.17). After PS matching, 105 patients treated with ceftaroline were matched with 105 controls: the 30-day mortality rates were 21.9% and 16.2% (p=0.38). Cox-regression analysis of the entire cohort (n=429) revealed that age (HR 1.05, 95%CI 1.03-1.07) and SOFA score>2 (HR 2.34, 95%CI 1.50-3.65) were associated with 90-day mortality risk, although ceftaroline treatment did not demonstrate a significant effect (HR 1.00, 95%CI 0.97-1.02). Incidence of AEs was 12.0% in ceftaroline vs. 4.4% in SOC group (p<0.01). Most AEs occurred when ceftaroline was used in combination vs. monotherapy (17.2% vs. 2.2%; p=0.01)., Conclusions: Ceftaroline was an effective treatment for MRSA-BSIs but was commonly prescribed in combination showing a higher incidence of AEs., Competing Interests: Transparency declarations S.V. has received financial support from Pfizer(TM) for speaking engagements and attendance at conferences. L.B.P. has financial support for attending meetings from Menarini(TM) and Pfizer(TM). L.B. has received payment for consulting fees from Angelini(TM), Jannsen(TM) and Shionogi(TM) and for lecture fees and advisory boards from Jannsen(TM), ViiV(TM) and GILEAD(TM). All the rest authors reported no conflict of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest., (Copyright © 2024 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)

Published
2024
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