Search

Your search keyword '"Gohh, Reginald"' showing total 322 results
Start Over Author "Gohh, Reginald"
322 results on '"Gohh, Reginald"'

1. Long-Term Results from an Open-Label Extension Study of Atacicept for the Treatment of IgA Nephropathy

Author

Barratt, Jonathan, Barbour, Sean, Brenner, Robert, Cooper, Kerry, Wei, Xuelian, Eren, Necmi, Floege, Jürgen, Jha, Vivekanand, Kim, Sung Gyun, Maes, Bart, Phoon, Richard K.S., Singh, Harmeet, Tesař, Vladimír, Lafayette, Richard, Umanath, Kausik, Kopyt, Nelson, Lafayette, Richard, Singh, Harmeet, Yalavarthy, Rajesh, Campbell, Kirk, Gohh, Reginald, Shah, Ankur, Zhang, Jingjing, Kumar, Jayant, Barbour, Sean, Bouquegneau, Antoine, Maes, Bart, Speeckaert, Marijn, Vielhauer, Volker, Hugo, Christian, Nitschke, Martin, Tokgoz, Bulent, Eren, Necmi, Rydzewski, Andrzej, Doulton, Timothy, Power, Albert, Hall, Matthew, Willcocks, Lisa, Tesar, Vladimir, Rychlik, Ivan, Goumenos, Dimitrios, Papagianni, Aikaterini, Stangou, Maria, Boletis, Ioannis, Marinaki, Smaragdi, Stylianou, Konstantinos, Zermpala, Synodi, Ntounousi, Evangelia, Gang, Sishir, Alexander, Suceena, Pandey, Rajendra, Dalal, Sonal, Sunil, R, Khetan, Prakash, Jain, Alok, Park, Hyeong Cheon, Kim, Dong Ki, Kim, Sung Gyun, Kim, Beom Seok, Levidiotis, Vicki, Pedagogos, Eugenia, Francis, Ross, Ryan, Jessica, Phoon, Richard, Yahya, Rosnawati, Nor, Bin Mohd, Safhan, Fariz, Lim, Soo Kun, and Teng, Kok Seng

Published
2024
Full Text
View/download PDF

3. Posoleucel in Kidney Transplant Recipients with BK Viremia: Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial

Author

Chandraker, Anil, Regmi, Anil, Gohh, Reginald, Sharma, Akhil, Woodle, E. Steve, Ansari, Mohammed J., Nair, Vinay, Chen, Ling-Xin, Alhamad, Tarek, Norman, Silas, Cibrik, Diane, Singh, Manpreet, Alper, Arnold, Jain, Divya, Zaky, Ziad, Knechtle, Stuart, Sharfuddin, Asif, Gupta, Gaurav, Lonze, Bonnie E., Young, Jo-Anne H., Adey, Deborah, Faravardeh, Arman, Dadhania, Darshana M., Rossi, Ana P., Florescu, Diana, Cardarelli, Francesca, Ma, Julie, Gilmore, Sarah, Vasileiou, Spyridoula, Jindra, Peter T., and Wojciechowski, David

Published
2024
Full Text
View/download PDF

5. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Au Peh, Chen, Chakera, Aron, Cooper, Bruce, Kurtkoti, Jagadeesh, Langguth, Daman, Levidiotis, Vicki, Luxton, Grant, Mount, Peter, Mudge, David, Noble, Euan, Phoon, Richard, Ranganathan, Dwarakanathan, Ritchie, Angus, Ryan, Jessica, Suranyi, Michael, Rosenkranz, Alexander, Lhotta, Karl, Kronbichler, Andreas, Demoulin, Nathalie, Bovy, Christophe, Hellemans, Rachel, Hougardy, Jean-Michel, Sprangers, Ben, Wissing, Karl Martin, Pagnoux, Christian, Barbour, Sean, Brachemi, Soumeya, Cournoyer, Serge, Girard, Louis-Philippe, Laurin, Louis-Philippe, Liang, Patrick, Philibert, David, Walsh, Michael, Tesar, Vladimir, Becvar, Radim, Horak, Pavel, Rychlik, Ivan, Szpirt, Wladimir, Dieperink, Hans, Gregersen, Jon Waarst, Ivarsen, Per, Krarup, Elizabeth, Lyngsoe, Cecilie, Rigothier, Claire, Augusto, Jean-Francois, Belot, Alexandre, Chauveau, Dominique, Cornec, Divi, Jourde-Chiche, Noemie, Ficheux, Maxence, Karras, Alexandre, Klein, Alexandre, Maurier, Francois, Mesbah, Rafik, Moranne, Olivier, Neel, Antoine, Quemeneur, Thomas, Saadoun, David, Terrier, Benjamin, Zaoui, Philippe, Schaier, Matthias, Benck, Urs Tobias, Bergner, Raoul, Busch, Martin, Floege, Juergen, Grundmann, Franziska, Haller, Hermann, Haubitz, Marion, Hellmich, Bernhard, Henes, Joerg Christoph, Hohenstein, Bernd, Hugo, Christian, Iking-Konert, Christof, Arndt, Fabian, Kubacki, T, Kotter, Ina, Lamprecht, Peter, Lindner, Tom, Halbritter, Jan, Mehling, Heidrun, Schönermarck, Ulf, Venhoff, Nils, Vielhauer, Volker, Witzke, Oliver, Szombati, Istvan, Szucs, Gabriella, Garibotto, Giacomo, Alberici, Federico, Brunetta, Enrico, Dagna, Lorenzo, De Vita, Salvatore, Emmi, Giacomo, Gabrielli, Armando, Manenti, Lucio, Pieruzzi, Federico, Roccatello, Dario, Salvarani, Carlo, Harigai, Masayoshi, Dobashi, Hiroaki, Atsumi, Tatsuya, Fujimoto, Shoichi, Hagino, Noboru, Ihata, Atsushi, Kaname, Shinya, Kaneko, Yuko, Katagiri, Akira, Katayama, Masao, Kirino, Yohei, Kitagawa, Kiyoki, Komatsuda, Atsushi, Kono, Hajime, Kurasawa, Takahiko, Matsumura, Ryutaro, Mimura, Toshihide, Morinobu, Akio, Murakawa, Yohko, Naniwa, Taio, Nanki, Toshihiro, Ogawa, Noriyoshi, Oshima, Hisaji, Sada, Kenei, Sugiyama, Eiji, Takeuchi, Tohru, Taki, Hirofumi, Tamura, Naoto, Tsukamoto, Tatsuo, Yamagata, Kunihiro, Yamamura, Masahiro, van Daele, Paulus Leon Arthur, Rutgers, Abraham, Teng, Y.K. Onno, Walker, Robert, Chua, Ignatius, Collins, Michael, Rabindranath, Kannaiyan, de Zoysa, Janak, Svensson, My Hanna Sofia, Grevbo, Bard-Waldum, Kalstad, Synove, Little, Mark, Clarkson, Michael, Molloy, Eamonn, Agraz Pamplona, Irene, Anton, Jordi, Barrio Lucia, Vicente, Ciggaran, Secundino, Cinta Cid, Maria, Diaz Encarnacion, Montserrat, Fulladosa Oliveras, Xavier, Jose Soler, Maria, Marco Rusinol, Helena, Praga, Manuel, Quintana Porras, Luis, Segarra, Alfons, Bruchfeld, Annette, Segelmark, Marten, Soveri, Inga, Thomaidi, Eleni, Westman, Kerstin, Neumann, Thomas, Burnier, Michel, Daikeler, Thomas, Dudler, Jean, Hauser, Thomas, Seeger, Harald, Vogt, Bruno, Burton, James, Al Jayyousi, Reem, Amin, Tania, Andrews, Jacqueline, Baines, Laura Anne, Brogan, Paul, Dasgupta, Bhaskar, Doulton, Timothy William Ronald, Flossmann, Oliver, Griffin, Sian V., Harper, Janice Marian, Harper, Lorraine, Kidder, Dana, Klocke, Rainer, Lanyon, Peter Charles, Luqmani, Raashid, McLaren, John Stuart, Makanjuola, David Osagie, McCann, Liza, Nandagudi, Anupama C., Selvan, Shilpa, O'Riordan, Edmond, Patel, Mumtaz, Patel, Rajan Kantilal, Pusey, Charles Dickson, Rajakariar, Ravindra, Robson, Joanna C., Robson, Michael, Salama, Alan David, Smyth, Lucy, Sznajd, Jan, Taylor, Joanne, Sreih, Antonie G., Belilos, Elise, Bomback, Andrew S., Carlin, Jeffrey, Chang Chen Lin, Yih, Derebail, Vimal K., Dragoi, Serban, Dua, Anisha, Forbess, Lindsy, Geetha, Duvuru, Gipson, Patrick, Gohh, Reginald, Greenwood, Gregory Todd, Hugenberg, Steven T., Jimenez, Richard A.H., Kaskas, Marwan Omar, Kermani, Tanaz, Kivitz, Alan J., Koening, Curry, Langford, Carol A., Marder, Galina, Mohamed, Amr Ahmed El-Huesseini, Monach, Paul, Neyra, Nilda Roxana, Niemer, Gregory W., Niles, John, Obi, Reginald, Owens, Charles, Parks, Deborah L., Podoll, Amber S., Rovin, Brad, Sam, R, Shergy, William Julius, Silva, Arnold Lawrence, Specks, Ulrich, Spiera, Robert, Springer, Jason M., Striebich, Christopher Charles, Swarup, Areena, Thakar, Surabhi, Tiliakos, Athan N., Tsai, Yong, Waguespack, Dia R., Chester Wasko, Mary, Strand, Vibeke, Jayne, David R W, Horomanski, Audra, Yue, Huibin, Bekker, Pirow, and Merkel, Peter A

Published
2023
Full Text
View/download PDF

7. Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure

Author

Bostom, Andrew, Steubl, Dominik, Garimella, Pranav S, Franceschini, Nora, Roberts, Mary B, Pasch, Andreas, Ix, Joachim H, Tuttle, Katherine R, Ivanova, Anastasia, Shireman, Theresa, Kim, S Joseph, Gohh, Reginald, Weiner, Daniel E, Levey, Andrew S, Hsu, Chi-yuan, Kusek, John W, and Eaton, Charles B

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Organ Transplantation, Clinical Research, Transplantation, Cardiovascular, Prevention, Kidney Disease, Renal and urogenital, Adult, Allografts, Cohort Studies, Female, Humans, Kidney Transplantation, Male, Middle Aged, Renal Insufficiency, Uromodulin, Serum uromodulin, Kidney transplantation, Kidney allograft failure, Urology & Nephrology, Clinical sciences
Abstract

BackgroundUromodulin is a kidney-derived glycoprotein and putative tubular function index. Lower serum uromodulin was recently associated with increased risk for kidney allograft failure in a preliminary, longitudinal single-center -European study involving 91 kidney transplant recipients (KTRs).MethodsThe Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial is a completed, large, multiethnic controlled clinical trial cohort, which studied chronic, stable KTRs. We conducted a case cohort analysis using a randomly selected subset of patients (random subcohort, n = 433), and all individuals who developed kidney allograft failure (cases, n = 226) during follow-up. Serum uromodulin was determined in this total of n = 613 FAVORIT trial participants at randomization. Death-censored kidney allograft failure was the study outcome.ResultsThe 226 kidney allograft failures occurred during a median surveillance of 3.2 years. Unadjusted, weighted Cox proportional hazards modeling revealed that lower serum uromodulin, tertile 1 vs. tertile 3, was associated with a threefold greater risk for kidney allograft failure (hazards ratio [HR], 95% CI 3.20 [2.05-5.01]). This association was attenuated but persisted at twofold greater risk for allograft failure, after adjustment for age, sex, smoking, allograft type and vintage, prevalent diabetes mellitus and cardiovascular disease (CVD), total/high-density lipoprotein cholesterol ratio, systolic blood pressure, estimated glomerular filtration rate, and natural log urinary albumin/creatinine: HR 2.00, 95% CI (1.06-3.77).ConclusionsLower serum uromodulin, a possible indicator of less well-preserved renal tubular function, remained associated with greater risk for kidney allograft failure, after adjustment for major, established clinical kidney allograft failure and CVD risk factors, in a large, multiethnic cohort of long-term, stable KTRs.

Published
2018

11. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Strand, Vibeke, primary, Jayne, David R W, additional, Horomanski, Audra, additional, Yue, Huibin, additional, Bekker, Pirow, additional, Merkel, Peter A, additional, Au Peh, Chen, additional, Chakera, Aron, additional, Cooper, Bruce, additional, Kurtkoti, Jagadeesh, additional, Langguth, Daman, additional, Levidiotis, Vicki, additional, Luxton, Grant, additional, Mount, Peter, additional, Mudge, David, additional, Noble, Euan, additional, Phoon, Richard, additional, Ranganathan, Dwarakanathan, additional, Ritchie, Angus, additional, Ryan, Jessica, additional, Suranyi, Michael, additional, Rosenkranz, Alexander, additional, Lhotta, Karl, additional, Kronbichler, Andreas, additional, Demoulin, Nathalie, additional, Bovy, Christophe, additional, Hellemans, Rachel, additional, Hougardy, Jean-Michel, additional, Sprangers, Ben, additional, Wissing, Karl Martin, additional, Pagnoux, Christian, additional, Barbour, Sean, additional, Brachemi, Soumeya, additional, Cournoyer, Serge, additional, Girard, Louis-Philippe, additional, Laurin, Louis-Philippe, additional, Liang, Patrick, additional, Philibert, David, additional, Walsh, Michael, additional, Tesar, Vladimir, additional, Becvar, Radim, additional, Horak, Pavel, additional, Rychlik, Ivan, additional, Szpirt, Wladimir, additional, Dieperink, Hans, additional, Gregersen, Jon Waarst, additional, Ivarsen, Per, additional, Krarup, Elizabeth, additional, Lyngsoe, Cecilie, additional, Rigothier, Claire, additional, Augusto, Jean-Francois, additional, Belot, Alexandre, additional, Chauveau, Dominique, additional, Cornec, Divi, additional, Jourde-Chiche, Noemie, additional, Ficheux, Maxence, additional, Karras, Alexandre, additional, Klein, Alexandre, additional, Maurier, Francois, additional, Mesbah, Rafik, additional, Moranne, Olivier, additional, Neel, Antoine, additional, Quemeneur, Thomas, additional, Saadoun, David, additional, Terrier, Benjamin, additional, Zaoui, Philippe, additional, Schaier, Matthias, additional, Benck, Urs Tobias, additional, Bergner, Raoul, additional, Busch, Martin, additional, Floege, Juergen, additional, Grundmann, Franziska, additional, Haller, Hermann, additional, Haubitz, Marion, additional, Hellmich, Bernhard, additional, Henes, Joerg Christoph, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Iking-Konert, Christof, additional, Arndt, Fabian, additional, Kubacki, T, additional, Kotter, Ina, additional, Lamprecht, Peter, additional, Lindner, Tom, additional, Halbritter, Jan, additional, Mehling, Heidrun, additional, Schönermarck, Ulf, additional, Venhoff, Nils, additional, Vielhauer, Volker, additional, Witzke, Oliver, additional, Szombati, Istvan, additional, Szucs, Gabriella, additional, Garibotto, Giacomo, additional, Alberici, Federico, additional, Brunetta, Enrico, additional, Dagna, Lorenzo, additional, De Vita, Salvatore, additional, Emmi, Giacomo, additional, Gabrielli, Armando, additional, Manenti, Lucio, additional, Pieruzzi, Federico, additional, Roccatello, Dario, additional, Salvarani, Carlo, additional, Harigai, Masayoshi, additional, Dobashi, Hiroaki, additional, Atsumi, Tatsuya, additional, Fujimoto, Shoichi, additional, Hagino, Noboru, additional, Ihata, Atsushi, additional, Kaname, Shinya, additional, Kaneko, Yuko, additional, Katagiri, Akira, additional, Katayama, Masao, additional, Kirino, Yohei, additional, Kitagawa, Kiyoki, additional, Komatsuda, Atsushi, additional, Kono, Hajime, additional, Kurasawa, Takahiko, additional, Matsumura, Ryutaro, additional, Mimura, Toshihide, additional, Morinobu, Akio, additional, Murakawa, Yohko, additional, Naniwa, Taio, additional, Nanki, Toshihiro, additional, Ogawa, Noriyoshi, additional, Oshima, Hisaji, additional, Sada, Kenei, additional, Sugiyama, Eiji, additional, Takeuchi, Tohru, additional, Taki, Hirofumi, additional, Tamura, Naoto, additional, Tsukamoto, Tatsuo, additional, Yamagata, Kunihiro, additional, Yamamura, Masahiro, additional, van Daele, Paulus Leon Arthur, additional, Rutgers, Abraham, additional, Teng, Y.K. Onno, additional, Walker, Robert, additional, Chua, Ignatius, additional, Collins, Michael, additional, Rabindranath, Kannaiyan, additional, de Zoysa, Janak, additional, Svensson, My Hanna Sofia, additional, Grevbo, Bard-Waldum, additional, Kalstad, Synove, additional, Little, Mark, additional, Clarkson, Michael, additional, Molloy, Eamonn, additional, Agraz Pamplona, Irene, additional, Anton, Jordi, additional, Barrio Lucia, Vicente, additional, Ciggaran, Secundino, additional, Cinta Cid, Maria, additional, Diaz Encarnacion, Montserrat, additional, Fulladosa Oliveras, Xavier, additional, Jose Soler, Maria, additional, Marco Rusinol, Helena, additional, Praga, Manuel, additional, Quintana Porras, Luis, additional, Segarra, Alfons, additional, Bruchfeld, Annette, additional, Segelmark, Marten, additional, Soveri, Inga, additional, Thomaidi, Eleni, additional, Westman, Kerstin, additional, Neumann, Thomas, additional, Burnier, Michel, additional, Daikeler, Thomas, additional, Dudler, Jean, additional, Hauser, Thomas, additional, Seeger, Harald, additional, Vogt, Bruno, additional, Burton, James, additional, Al Jayyousi, Reem, additional, Amin, Tania, additional, Andrews, Jacqueline, additional, Baines, Laura Anne, additional, Brogan, Paul, additional, Dasgupta, Bhaskar, additional, Doulton, Timothy William Ronald, additional, Flossmann, Oliver, additional, Griffin, Sian V., additional, Harper, Janice Marian, additional, Harper, Lorraine, additional, Kidder, Dana, additional, Klocke, Rainer, additional, Lanyon, Peter Charles, additional, Luqmani, Raashid, additional, McLaren, John Stuart, additional, Makanjuola, David Osagie, additional, McCann, Liza, additional, Nandagudi, Anupama C., additional, Selvan, Shilpa, additional, O'Riordan, Edmond, additional, Patel, Mumtaz, additional, Patel, Rajan Kantilal, additional, Pusey, Charles Dickson, additional, Rajakariar, Ravindra, additional, Robson, Joanna C., additional, Robson, Michael, additional, Salama, Alan David, additional, Smyth, Lucy, additional, Sznajd, Jan, additional, Taylor, Joanne, additional, Sreih, Antonie G., additional, Belilos, Elise, additional, Bomback, Andrew S., additional, Carlin, Jeffrey, additional, Chang Chen Lin, Yih, additional, Derebail, Vimal K., additional, Dragoi, Serban, additional, Dua, Anisha, additional, Forbess, Lindsy, additional, Geetha, Duvuru, additional, Gipson, Patrick, additional, Gohh, Reginald, additional, Greenwood, Gregory Todd, additional, Hugenberg, Steven T., additional, Jimenez, Richard A.H., additional, Kaskas, Marwan Omar, additional, Kermani, Tanaz, additional, Kivitz, Alan J., additional, Koening, Curry, additional, Langford, Carol A., additional, Marder, Galina, additional, Mohamed, Amr Ahmed El-Huesseini, additional, Monach, Paul, additional, Neyra, Nilda Roxana, additional, Niemer, Gregory W., additional, Niles, John, additional, Obi, Reginald, additional, Owens, Charles, additional, Parks, Deborah L., additional, Podoll, Amber S., additional, Rovin, Brad, additional, Sam, R, additional, Shergy, William Julius, additional, Silva, Arnold Lawrence, additional, Specks, Ulrich, additional, Spiera, Robert, additional, Springer, Jason M., additional, Striebich, Christopher Charles, additional, Swarup, Areena, additional, Thakar, Surabhi, additional, Tiliakos, Athan N., additional, Tsai, Yong, additional, Waguespack, Dia R., additional, and Chester Wasko, Mary, additional

Published
2023
Full Text
View/download PDF

12. Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial

Author

Denny, Jason E., Kulkarni, Sanjay, Hricik, Donald, Bresnahan, Barbara A., Bunnapradist, Suphamai, El-Sabrout, Rafik A., Chan, Laurence K., Ciancio, Gaetano, El-Ghoroury, Mohamed A., Goldstein, Michael J., Gaston, Robert S., Gohh, Reginald Y., Killackey, Mary T., King, Anne, Knight, Richard J., Kore, Arputharaj H., Sudan, Debra L., Chapochnick Friedmann, Javier, Mulgaonkar, Shamkant P., Nolan, Charles, Pankewycz, Oleh G., Pirsch, John D., Schaefer, Heidi M., Steinberg, Steven M., Gelb, Bruce E., True, Karin A., West-Thielke, Patricia M., Waybill, Mary M., Wolf, Joshua H., Ketel, Beverley L., Harland, Robert C., Shihab, Fuad S., Cassuto, Elisabeth, Le Meur, Yannick, Rostaing, Lionel, Mariat, Christophe, Grinyó, Josep Maria, Puig, Jose, Seron, Daniel, Tisone, Giuseppe, Ciechanowski, Kazimierz, Foroncewicz, Bartosz, Wlodarczyk, Zbigniew, Budde, Klemens, Witzke, Oliver, Mondragon, Guillermo A., Mancilla Urrea, Eduardo, Alberu Gomez, Josefina, Reyes Acevedo, Rafael, Rial, Maria del Carmen, Novoa, Pablo A., Silva, Helio T., Jr., Garcia, Valter D., Carvalho, Deise D., Santamaria Saber, Luciana T., Contieri, Fabiana L., Bastos, Marcos G., Manfro, Roberto C., Kanellis, John, Eris, Josette, O’Connell, Philip, Hughes, Peter, Russ, Graeme, Pidgeon, Grant B., Dittmer, Ian D., Kee, Terence, Vathsala, Anantharaman, Naumovic, Radomir, Mitic, Igor, Parmjeet, Randhawa, Grinyó, Josep M., and Silva, Helio Tedesco, Jr.

Published
2016
Full Text
View/download PDF

19. Implementing a regional standardized BK polyomavirus screening protocol across eleven transplant centres

Author

Rogers, Ralph, primary, Bodziak, Kenneth, additional, Cheema, Faiqa, additional, Chobanian, Michael, additional, Ebcioglu, Zeynep, additional, Gabardi, Steven, additional, Ghai, Sandeep, additional, Gilligan, Hannah, additional, Gohh, Reginald, additional, Goyal, Nitender, additional, Kavalam, George, additional, Mehri, Basma, additional, Rodig, Nancy, additional, Rossi, Ana, additional, Singh, Joseph, additional, Wood, Emily, additional, Tan, Chen Sabrina, additional, and Pavlakis, Martha, additional

Published
2021
Full Text
View/download PDF

23. Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era

Author

Farmakiotis, Dimitrios, Weiss, Zoe, Brotherton, Amy L., Morrissey, Paul, Gohh, Reginald, Vieira, Kendra, Taylor, Lynn E., and Garland, Joseph M.

Subjects
surgical procedures, operative, Article Subject, virus diseases, digestive system diseases
Abstract

Despite significant advances in transplantation of HIV-infected individuals, little is known about HIV coinfected patients with hepatitis C virus (HCV) genotypes other than genotype 1, especially when receiving HCV-infected organs with a different genotype. We describe the first case of kidney transplantation in a man coinfected with hepatitis C and HIV in our state. To our knowledge, this is also the first report of an HIV/HCV/HBV tri-infected patient with non-1 (2a) HCV genotype who received an HCV-infected kidney graft with the discordant genotype (1a), to which he converted after transplant. Our case study highlights the following: (1) transplant centers need to monitor wait times for an HCV-infected organ and regularly assess the risk of delaying HCV antiviral treatment for HCV-infected transplant candidates in anticipation of the transplant from an HCV-infected donor; (2) closer monitoring of tacrolimus levels during the early phases of anti-HCV protease inhibitor introduction and discontinuation may be indicated; (3) donor genotype transmission can occur; (4) HIV/HCV coinfected transplant candidates require a holistic approach with emphasis on the cardiovascular risk profile and low threshold for cardiac catheterization as part of their pretransplant evaluation.

Published
2020
Full Text
View/download PDF

44. Management of Cardiovascular Risk factors in Dialysis-Dependent End Stage Kidney Disease.

Author

KOTA, HARSHITHA and GOHH, REGINALD

Subjects
*KIDNEY diseases, *CARDIOVASCULAR diseases risk factors, *DYSLIPIDEMIA, *AMBULATORY blood pressure monitoring, *CARDIOVASCULAR diseases, *RENIN-angiotensin system, *KIDNEY transplantation
Abstract

The article discusses the management of cardiovascular risk factors in dialysis-dependent end stage kidney disease (ESKD). Topics covered include kidney transplantation as the preferred treatment with proven clinical outcomes for ESKD, proposed novel risk factors that may be contributing to the higher incidence of mortality and cardiovascular disease (CVD) unique to chronic kidney disease (CKD) and ESKD population, and change in the use of aspirin as primary prevention in the general population.

Published
2021

45. Successful recovery from COVID‐19 in three kidney transplant recipients who received convalescent plasma therapy.

Author

Naeem, Syed, Gohh, Reginald, Bayliss, George, Cosgrove, Christopher, Farmakiotis, Dimitrios, Merhi, Basma, Morrissey, Paul, Osband, Adena, Bailey, Jeffrey A., Sweeney, Joseph, and Rogers, Ralph

Subjects
*CONVALESCENT plasma, *COVID-19, *KIDNEY transplantation, *SARS-CoV-2, *VIRAL transmission
Abstract

Novel coronavirus disease 2019 (COVID‐19) is a highly infectious, rapidly spreading viral disease that typically presents with greater severity in patients with underlying medical conditions or those who are immunosuppressed. We present a novel case series of three kidney transplant recipients with COVID‐19 who recovered after receiving COVID‐19 convalescent plasma (CCP) therapy. Physicians should be aware of this potentially useful treatment option. Larger clinical registries and randomized clinical trials should be conducted to further explore the clinical and allograft outcomes associated with CCP use in this population. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

46. Treprostinil, a prostacyclin analog, ameliorates renal ischemia–reperfusion injury: preclinical studies in a rat model of acute kidney injury.

Author

Meiwen Ding, Tolbert, Evelyn, Birkenbach, Mark, Gohh, Reginald, Ghonem, Nisanne S., and Akhlaghi, Fatemeh

Abstract

Background. Renal ischemia–reperfusion injury (IRI) is a major factor causing acute kidney injury (AKI). No pharmacological treatments for prevention or amelioration of I/R-induced renal injury are available. Here we investigate the protective effects of treprostinil, a prostacyclin analog, against renal IRI in vivo. Methods. Male Sprague Dawley rats were subjected to bilateral renal ischemia (45 min) followed by reperfusion for 1–168 h. Treprostinil (100 ng/kg/min) or placebo was administered subcutaneously for 18–24 h before ischemia. Results. Treatment with treprostinil both significantly reduced peak elevation and accelerated the return to baseline levels for serum creatinine and blood urea nitrogen versus I/R-placebo animals following IRI. I/R-treprostinil animals exhibited reduced histopathological features of tubular epithelial injury versus I/R-placebo animals. IRI resulted in a marked induction of messenger RNA coding for kidney injury biomarkers, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin and for pro-inflammatory cytokines chemokine (C-C motif) ligand 2, interleukin 1b, interleukin 6 and intracellular adhesion molecular 1 in animals treated with placebo only relative to sham controls. Upregulation of expression of all these genes was significantly suppressed by treprostinil. Treprostinil significantly suppressed the elevation in renal lipid peroxidation found in the I/R-placebo group at 1-h post-reperfusion. In addition, renal protein expression of cleaved poly(ADP-ribose) polymerase 1 and caspase-3, -8 and -9 in I/R-placebo animals was significantly inhibited by treprostinil. Conclusions. This study demonstrates the efficacy of treprostinil in ameliorating I/R-induced AKI in rats by significantly improving renal function early post-reperfusion and by inhibiting renal inflammation and tubular epithelial apoptosis. Importantly, these data suggest that treprostinil has the potential to serve as a therapeutic agent to protect the kidney against IRI in vivo. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

47. Kidney Transplantation and COVID-19.

Author

MERHI, BASMA and GOHH, REGINALD

Subjects
*COVID-19, *KIDNEY transplantation, *IMMUNE reconstitution inflammatory syndrome, *COVID-19 pandemic
Abstract

The article discusses kidney transplantation is the treatment of choice for patients with advanced chronic kidney disease or end stage kidney disease. Topics include kidney transplant recipients receive induction therapy at the time of transplant, followed by a maintenance immunosuppressive protocol consisting of prednisone, calcineurin inhibitor and the Centers for Disease Control and Prevention (CDC) lists immunocompromised patients as at high-risk for developing severe disease from COVID-19.

Published
2020

48. Hyperammonemia syndrome due to Ureaplasma urealyticum in a kidney transplant recipient: A case of disseminated disease from a fluoroquinolone‐resistant isolate.

Author

Higgins, Andrea B., Farmakiotis, Dimitrios, Rogers, Ralph, Osband, Adena J., Seo, Angie, Chen, Brendan, Birkenbach, Mark P., Crabb, Donna, Xiao, Li, Leal, Sixto, Waites, Ken, Gohh, Reginald, Morrissey, Paul, and Nau, Gerard J.

Subjects
KIDNEY transplantation, UREAPLASMA, HYPERAMMONEMIA, DRUG resistance in microorganisms, SYNOVIAL fluid
Abstract

Ureaplasma species (spp.) are common colonizers of the urogenital tract but may cause systemic infection in immunocompromised patients. They release significant amounts of ammonia via urea hydrolysis and have been recently implicated in the pathogenesis of hyperammonemia syndrome after organ transplantation. We describe a unique case of hyperammonemia syndrome after kidney transplant caused by U urealyticum infection, and the first, to our knowledge, case of a fluoroquinolone‐resistant Ureaplasma strain causing hyperammonemia syndrome. A 17‐year‐old female developed intermittent fevers, rising creatinine, sterile pyuria and debilitating polyarthritis approximately 1 year after kidney transplant. Serum ammonia level was elevated, and urine PCR was positive for U urealyticum. Near the end of treatment with levofloxacin, she had rebound hyperammonemia, which preceded clinical relapse of polyarthritis and encephalopathy. Blood and urine PCR and synovial fluid culture were positive for U urealyticum. Susceptibility testing showed fluoroquinolone resistance, but she responded well to azithromycin and doxycycline. The frequency of Ureaplasma spp. infection in immunocompromised patients is probably underestimated due to diagnostic challenges. Ammonia levels were helpful biomarkers of response to antimicrobial therapy in our case. Susceptibility testing of clinical isolates should be pursued. In serious Ureaplasma spp. infections, particularly in immunocompromised patients, two empiric antibiotics may be indicated given the potential for antimicrobial resistance. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

49. New England BK consortium: Regional survey of BK screening and management protocols in comparison to published consensus guidelines

Author

Gabardi, Steven, primary, Pavlakis, Martha, additional, Tan, Chen, additional, Francis, Jean, additional, Cardarelli, Francesca, additional, Asch, William, additional, Bodziak, Kenneth, additional, Chobanian, Michael, additional, Gilligan, Hannah, additional, Gohh, Reginald, additional, Kung, Shiang-Cheng, additional, Inker, Lesley, additional, Martin, Spencer, additional, Rodig, Nancy, additional, Rossi, Ana, additional, and Chandraker, Anil, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results