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17 results on '"Goh, C.Y."'

6. Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

Author

Roelofs, P.A., Goh, C.Y., Chua, B.H., Jarvis, M.C., Stewart, T.A., McCann, J.L., McDougle, R.M., Carpenter, M.A., Martens, J.W.M. (John), Span, P.N. (Paul), Kappei, D. (Dennis), Harris, R. S., Roelofs, P.A., Goh, C.Y., Chua, B.H., Jarvis, M.C., Stewart, T.A., McCann, J.L., McDougle, R.M., Carpenter, M.A., Martens, J.W.M. (John), Span, P.N. (Paul), Kappei, D. (Dennis), and Harris, R. S.

Abstract

APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element mediates repression in normal cells and that expression is activated by its mutational disruption in a reporter construct or the endogenous A3B gene. The same E2F site is required for A3B induction by polyomavirus T antigen indicating a shared molecular mechanism. Proteomic and biochemical experiments demonstrate the binding of wildtype but not mutant E2F promoters by repressive PRC1.6/E2F6 and DREAM/E2F4 complexes. Knockdown and overexpression studies confirm the involvement of these repressive complexes in regulating A3B expression. Altogether, these studies demonstrate that A3B expression is suppressed in normal cells by repressive E2F complexes and that viral or mutational disruption of this regulatory network triggers overexpression in breast cancer and provides fuel for tumor evolution.

Published
2020
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10. P5583Comparison of short-term clinical outcomes of proximal versus non-proximal culprit lesion in patients treated with primary percutaneous coronary intervention for ST-elevation myocardial infarction

Author

Noaman, S., primary, Vogrin, S., additional, Goh, C.Y., additional, Cheng, Y., additional, Brennan, A.L., additional, Andrianopoulos, N., additional, Dinh, D., additional, Lefkovits, J., additional, Reid, C., additional, Walton, A., additional, Stub, D., additional, Cox, N., additional, and Chan, W., additional

Published
2017
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17. Long-term benefits of full-day kindergarten: a longitudinal population-based study.

Author

Brownell, M.D., Nickel, N.C., Chateau, D., Martens, P.J., Taylor, C., Crockett, L., Katz, A., Sarkar, J., Burland, E., and Goh, C.Y.

Subjects
FULL-day kindergarten, LONGITUDINAL method, SCHOOL day, SOCIAL status, ACADEMIC achievement, ELEMENTARY education, SIMILAR fact evidence, SCHOOL children, PRIMARY education, EARLY childhood education
Abstract

In the first longitudinal, population-based study of full-day kindergarten (FDK) outcomes beyond primary school in Canada, we used linked administrative data to follow 15 kindergarten cohorts (nranging from 112 to 736) up to grade 9. Provincial assessments conducted in grades 3, 7, and 8 and course marks and credits earned in grade 9 were compared between FDK and half-day kindergarten (HDK) students in both targeted and universal FDK programmes. Propensity score matched cohort and stepped-wedge designs allowed for stronger causal inferences than previous research on FDK. We found limited long-term benefits of FDK, specific to the type of programme, outcomes examined, and subpopulations. FDK programmes targeted at low-income areas showed long-term improvements in numeracy for lower income girls. Our results suggest that expectations for wide-ranging long-term academic benefits of FDK are unwarranted. [ABSTRACT FROM PUBLISHER]

Published
2015
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