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42 results on '"Gogcu, Semsa"'

4. Neurodevelopmental and behavioral outcomes of very preterm infants: latent profile analysis in the Environmental influences on Child Health Outcomes (ECHO) Program

Author

Camerota, Marie, McGowan, Elisabeth C., Aschner, Judy, Stroustrup, Annemarie, O’Shea, T. Michael, Hofheimer, Julie A., Joseph, Robert M., Musci, Rashelle, Taylor, Genevieve, Carter, Brian S., Check, Jennifer, Dansereau, Lynne M., Gogcu, Semsa, Helderman, Jennifer B., Neal, Charles R., Pastyrnak, Steven L., Smith, Lynne M., Marsit, Carmen J., and Lester, Barry M.

Published
2024
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5. Maternal stress and early childhood BMI among US children from the Environmental influences on Child Health Outcomes (ECHO) program

Author

Wood, Charles T., Churchill, Marie L., McGrath, Monica, Aschner, Judy, Brunwasser, Steven M., Geiger, Sarah, Gogcu, Semsa, Hartert, Tina V., Hipwell, Allison E., Lee-Sarwar, Kathleen, Lyall, Kristen, Moog, Nora K., O’Connor, Thomas G., O’Shea, T. Michael, Smith, P. Brian, Wright, Rosalind J., Zhang, Xueying, Zimmerman, Emily, Huddleston, Kathi C., and Brown, Callie L.

Published
2023
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7. Association Between Urinary Biomarkers and CKD in Extremely Low Gestational Age Neonates

Author

Thomas, Billy, Elhassan, Nahed, Mulkey, Sarah, Dydynski, Philip, Vijayamadhavan, Vivek K., Mulrooney, Neil, Yoder, Bradley, Kase, Jordan S., Check, Jennifer, Gogcu, Semsa, Osterholm, Erin, Ramel, Sara, Bendel, Catherine, Gale, Cheryl, George, Thomas, Georgieff, Michael, Gisslen, Tate, Guiang, Sixto, III, Hall, Anne, Johnson, Dana, Pfister, Katie, Podgorski, Heather, Roberts, Kari, Stepka, Erin, Engel, Melissa, Kamrath, Heidi, Scheurer, Johannah, Hanson, Angela, Satrom, Katherine, Pfister, Susan, Simones, Ann, Plummer, Erin, Zorn, Elizabeth, Martin, Camilia R., O’Reilly, Deirdre, Porta, Nicolas, Bazacliu, Catalina, Williams, Jonathan, Rajderkar, Dhanashree, Northington, Frances, Valdez, Raul Chavez, Beauman, Sandra, Saurabhkumar, Patel, Diaz-Barbosa, Magaly, Serize, Arturo, Jordan, Jorge, Ott, Debbie, Mora, Ariana Franco, Hedrick, Pamela, Flynn, Vicki, Silvia, Amy, Clopp, Bailey, Feltner, John B., Esposito, Isabella, Hauge, Stephanie, Nikirk, Samantha, Purnell, Andrea, Loy, Emilie, Sikes, Natalie, Mason, Melanie, McConnell, Jana, Brown, Tiffany, Harrison, Henry, Pearson, Denise, Drake, Tammy, Wright, Jocelyn, Walden, Debra, Guy, Annette, Nason, Jennifer, Talbot, Morgan, Lee, Kristen, Penny, Sarah, Boles, Terri, Drummond, Melanie, Kohlleppel, Katy, Kathen, Charmaine, Kaletka, Brian, Gonzales, Shania, Worwa, Cathy, Fisher, Molly, Richter, Tyler, Ginder, Alexander, Reich, Brixen, Rau, Carrie, Loertscher, Manndi, Bledsoe, Laura, McGrath, Kandace, Lewis, Kimberlee Weaver, Burnett, Jill, Schaefer, Susan, Bird, Karie, Giblin, Clare, Daly, Rita, Lanier, Kristi, Warden, Kelly, Wassenaar, Jenna, Ericksen, Jensina, Davern, Bridget, Osborne, Mary Pat, Gregorich, Brittany, Talele, Neha, Obregon, Evelyn, Ziyeh, Tiglath, Clarke, Molly, Wegner, Rachel E., Patel, Palak, Schau, Molly, Russow, Annamarie, Curry, Kelly, Sinnamon, Susan, Barnhart, Lisa, Parkinson, Charlamaine, Hanson, Mary, Kuan, Elizabeth, Lacy, Conra Backstrom, Galvis, Edshelee M., Bombino, Susana, Martinez, Denise, Bell, Suzi, Long, Corrie, Longa, Cathy, Westerveld, Michael, McConkey, Stacy, Hay, Anne, Natarajan, Niranjana, Gaudette, Shari, Cobb, Sarah, Sharp, Gregory, Schumacher, Elizabeth, Schuschke, Leslie, Frey, Charlotte, Fierro, Mario, Gilmore, Lois, Lundequam, Pamela, Hoekstra, Ronald, Ketko, Anastasia, Perdue, Nina, Cunningham, Sean, Stout, Kelly, Hall, Becky, Morshedzadeh, Galina, Ostrander, Betsy, Winter, Sarah, Cox, Lauren, Rainaldi, Matthew A., Hensley, Sarah, Morris, Melissa, Roberts, Dia, Tuttle, Melissa, Boys, Christopher, Hultgren, Solveig, Pierpont, Elizabeth I., Fahim, Nancy, George, Tom, King, Kelly E., Bataglia, Katherine, Neis, Cathy, Bergeron, Mark, Miller, Cristina, Accomando, Cara, Gavin, Jennifer Anne, Maczek, Elizabeth, Marakovitz, Susan, Knorr, Aimee, Smith, Vincent C., Stewart, Jane E., Weissbourd, Marie, deRegnier, Raye-Ann, Matoba, Nana, Heaton, Shelly C., Cascio, Erika M., Brady, Janet, Ghosh, Suman, Ditto, Jessica, Leppert, Mary, Lowe, Jean, Fuller, Janell, DuPont, Tara, Ohls, Robin, Kloska, Pamela, Patel, Saurabh, Carbonell, Lauren, Patino-Fernandez, Anna Maria, de Lerma, Carmen, McDonough, Kelly, De Cortada, Maiana, Chavis, Lacy, Shannon, Jane, Hingorani, Sangeeta R., Schmicker, Robert H., Halloran, Brian, Brophy, Patrick, Heagerty, Patrick J., Juul, Sandra, Goldstein, Stuart L., and Askenazi, David

Published
2024
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9. CpG methylation patterns in placenta and neonatal blood are differentially associated with neonatal inflammation

Author

Eaves, Lauren A., Enggasser, Adam E., Camerota, Marie, Gogcu, Semsa, Gower, William A., Hartwell, Hadley, Jackson, Wesley M., Jensen, Elizabeth, Joseph, Robert M., Marsit, Carmen J., Roell, Kyle, Santos Jr., Hudson P., Shenberger, Jeffrey S., Smeester, Lisa, Yanni, Diana, Kuban, Karl C. K., O’Shea, T. Michael, and Fry, Rebecca C.

Published
2023
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10. Predicting 2-year neurodevelopmental outcomes in extremely preterm infants using graphical network and machine learning approaches

Author

Wadhawan, Rajan, Courtney, Sherry E., Robinson, Tonya, Ahmad, Kaashif A., Bendel-Stenzel, Ellen, Baserga, Mariana, LaGamma, Edmund F., Downey, L. Corbin, Rao, Raghavendra, Fahim, Nancy, Lampland, Andrea, Frantz, Ivan D., III, Khan, Janine, Weiss, Michael, Gilmore, Maureen M., Srinivasan, Nishant, Perez, Jorge E., McKay, Victor, Juul, Sandra E., Wood, Thomas R., German, Kendell, Law, Janessa B., Kolnik, Sarah E., Puia-Dumitrescu, Mihai, Mietzsch, Ulrike, Gogcu, Semsa, Comstock, Bryan A., Li, Sijia, Mayock, Dennis E., and Heagerty, Patrick J.

Published
2023
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11. Psychiatric Outcomes, Functioning, and Participation in Extremely Low Gestational Age Newborns at Age 15 Years

Author

Frazier, Jean A., Cochran, David, Kim, Sohye, Jalnapurkar, Isha, Joseph, Robert M., Hooper, Stephen R., Santos, Hudson P., Jr., Ru, Hongyu, Venuti, Lauren, Singh, Rachana, Washburn, Lisa K., Gogcu, Semsa, Msall, Michael E., Kuban, Karl C.K., Rollins, Julie V., Hanson, Shannon G., Jara, Hernan, Pastyrnak, Steven L., Roell, Kyle R., Fry, Rebecca C., and O’Shea, T. Michael

Published
2022
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12. The Current State of Neonatal Neurodevelopmental Follow-up Programs in North America: A Children's Hospitals Neonatal Consortium Report.

Author

Quiñones Cardona, Vilmaris, Cohen, Susan S., Cook, Noah, Cizmeci, Mehmet N., Chandel, Amit, DiGeronimo, Robert, Gogcu, Semsa, Jano, Eni, Kojima, Katsuaki, Lee, Kyong-Soon, McAdams, Ryan M., Menkiti, Ogechukwu, Mietzsch, Ulrike, Peeples, Eric, Sewell, Elizabeth, Shenberger, Jeffrey S., Massaro, An N., Natarajan, Girija, Rao, Rakesh, and Dizon, Maria L. V.

Subjects
CROSS-sectional method, MEDICAL protocols, CHILD psychopathology, NEONATOLOGY, INTERPROFESSIONAL relations, SOCIAL determinants of health, CHILD health services, EVALUATION of human services programs, QUESTIONNAIRES, CHILDREN'S hospitals, DESCRIPTIVE statistics, LONGITUDINAL method, TELEMEDICINE, GESTATIONAL age, CHILD development, COMMUNICATION, PATIENT aftercare
Abstract

Objective This study aimed to determine neonatal neurodevelopmental follow-up (NDFU) practices across academic centers. Study Design This study was a cross-sectional survey that addressed center-specific neonatal NDFU practices within the Children's Hospitals Neonatal Consortium (CHNC). Results Survey response rate was 76%, and 97% of respondents had a formal NDFU program. Programs were commonly staffed by neonatologists (80%), physical therapists (77%), and nurse practitioners (74%). Median gestational age at birth identified for follow-up was ≤32 weeks (range 26–36). Median duration was 3 years (range 2–18). Ninety-seven percent of sites used Bayley Scales of Infant and Toddler Development, but instruments used varied across ages. Scores were recorded in discrete electronic data fields at 43% of sites. Social determinants of health data were collected by 63%. Care coordination and telehealth services were not universally available. Conclusion NDFU clinics are almost universal within CHNC centers. Commonalities and variances in practice highlight opportunities for data sharing and development of best practices. Key Points Neonatal NDFU clinics help transition high-risk infants home. Interdisciplinary neonatal intensive care unit follow-up brings together previously separated outpatient service lines. This study reviews the current state of neonatal NDFU in North America. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Retinopathy of prematurity and neurodevelopmental outcome and quality of life at 10 years of age

Author

Sri, Sudhir, primary, Jensen, Elizabeth, additional, Msall, Michael, additional, Yi, Joe, additional, Zhabotynsky, Vasyl, additional, Joseph, Robert, additional, Kuban, Karl, additional, Frazier, Jean, additional, Hooper, Stephen, additional, Santos, Hudson, additional, Gogcu, Semsa, additional, Shenberger, Jeffrey, additional, Fry, Rebecca, additional, and O'Shea, Thomas, additional

Published
2024
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15. Association Between Urinary Biomarkers and CKD in Extremely Low Gestational Age Neonates

Author

Hingorani, Sangeeta R., primary, Schmicker, Robert H., additional, Halloran, Brian, additional, Brophy, Patrick, additional, Heagerty, Patrick J., additional, Juul, Sandra, additional, Goldstein, Stuart L., additional, Askenazi, David, additional, Thomas, Billy, additional, Elhassan, Nahed, additional, Mulkey, Sarah, additional, Dydynski, Philip, additional, Vijayamadhavan, Vivek K., additional, Mulrooney, Neil, additional, Yoder, Bradley, additional, Kase, Jordan S., additional, Check, Jennifer, additional, Gogcu, Semsa, additional, Osterholm, Erin, additional, Ramel, Sara, additional, Bendel, Catherine, additional, Gale, Cheryl, additional, George, Thomas, additional, Georgieff, Michael, additional, Gisslen, Tate, additional, Guiang, Sixto, additional, Hall, Anne, additional, Johnson, Dana, additional, Pfister, Katie, additional, Podgorski, Heather, additional, Roberts, Kari, additional, Stepka, Erin, additional, Engel, Melissa, additional, Kamrath, Heidi, additional, Scheurer, Johannah, additional, Hanson, Angela, additional, Satrom, Katherine, additional, Pfister, Susan, additional, Simones, Ann, additional, Plummer, Erin, additional, Zorn, Elizabeth, additional, Martin, Camilia R., additional, O’Reilly, Deirdre, additional, Porta, Nicolas, additional, Bazacliu, Catalina, additional, Williams, Jonathan, additional, Rajderkar, Dhanashree, additional, Northington, Frances, additional, Valdez, Raul Chavez, additional, Beauman, Sandra, additional, Saurabhkumar, Patel, additional, Diaz-Barbosa, Magaly, additional, Serize, Arturo, additional, Jordan, Jorge, additional, Ott, Debbie, additional, Mora, Ariana Franco, additional, Hedrick, Pamela, additional, Flynn, Vicki, additional, Silvia, Amy, additional, Clopp, Bailey, additional, Feltner, John B., additional, Esposito, Isabella, additional, Hauge, Stephanie, additional, Nikirk, Samantha, additional, Purnell, Andrea, additional, Loy, Emilie, additional, Sikes, Natalie, additional, Mason, Melanie, additional, McConnell, Jana, additional, Brown, Tiffany, additional, Harrison, Henry, additional, Pearson, Denise, additional, Drake, Tammy, additional, Wright, Jocelyn, additional, Walden, Debra, additional, Guy, Annette, additional, Nason, Jennifer, additional, Talbot, Morgan, additional, Lee, Kristen, additional, Penny, Sarah, additional, Boles, Terri, additional, Drummond, Melanie, additional, Kohlleppel, Katy, additional, Kathen, Charmaine, additional, Kaletka, Brian, additional, Gonzales, Shania, additional, Worwa, Cathy, additional, Fisher, Molly, additional, Richter, Tyler, additional, Ginder, Alexander, additional, Reich, Brixen, additional, Rau, Carrie, additional, Loertscher, Manndi, additional, Bledsoe, Laura, additional, McGrath, Kandace, additional, Lewis, Kimberlee Weaver, additional, Burnett, Jill, additional, Schaefer, Susan, additional, Bird, Karie, additional, Giblin, Clare, additional, Daly, Rita, additional, Lanier, Kristi, additional, Warden, Kelly, additional, Wassenaar, Jenna, additional, Ericksen, Jensina, additional, Davern, Bridget, additional, Osborne, Mary Pat, additional, Gregorich, Brittany, additional, Talele, Neha, additional, Obregon, Evelyn, additional, Ziyeh, Tiglath, additional, Clarke, Molly, additional, Wegner, Rachel E., additional, Patel, Palak, additional, Schau, Molly, additional, Russow, Annamarie, additional, Curry, Kelly, additional, Sinnamon, Susan, additional, Barnhart, Lisa, additional, Parkinson, Charlamaine, additional, Hanson, Mary, additional, Kuan, Elizabeth, additional, Lacy, Conra Backstrom, additional, Galvis, Edshelee M., additional, Bombino, Susana, additional, Martinez, Denise, additional, Bell, Suzi, additional, Long, Corrie, additional, Longa, Cathy, additional, Westerveld, Michael, additional, McConkey, Stacy, additional, Hay, Anne, additional, Natarajan, Niranjana, additional, Gaudette, Shari, additional, Cobb, Sarah, additional, Sharp, Gregory, additional, Schumacher, Elizabeth, additional, Schuschke, Leslie, additional, Frey, Charlotte, additional, Fierro, Mario, additional, Gilmore, Lois, additional, Lundequam, Pamela, additional, Hoekstra, Ronald, additional, Ketko, Anastasia, additional, Perdue, Nina, additional, Cunningham, Sean, additional, Stout, Kelly, additional, Hall, Becky, additional, Morshedzadeh, Galina, additional, Ostrander, Betsy, additional, Winter, Sarah, additional, Cox, Lauren, additional, Rainaldi, Matthew A., additional, Hensley, Sarah, additional, Morris, Melissa, additional, Roberts, Dia, additional, Tuttle, Melissa, additional, Boys, Christopher, additional, Hultgren, Solveig, additional, Pierpont, Elizabeth I., additional, Fahim, Nancy, additional, George, Tom, additional, King, Kelly E., additional, Bataglia, Katherine, additional, Neis, Cathy, additional, Bergeron, Mark, additional, Miller, Cristina, additional, Accomando, Cara, additional, Gavin, Jennifer Anne, additional, Maczek, Elizabeth, additional, Marakovitz, Susan, additional, Knorr, Aimee, additional, Smith, Vincent C., additional, Stewart, Jane E., additional, Weissbourd, Marie, additional, deRegnier, Raye-Ann, additional, Matoba, Nana, additional, Heaton, Shelly C., additional, Cascio, Erika M., additional, Brady, Janet, additional, Ghosh, Suman, additional, Ditto, Jessica, additional, Leppert, Mary, additional, Lowe, Jean, additional, Fuller, Janell, additional, DuPont, Tara, additional, Ohls, Robin, additional, Kloska, Pamela, additional, Patel, Saurabh, additional, Carbonell, Lauren, additional, Patino-Fernandez, Anna Maria, additional, de Lerma, Carmen, additional, McDonough, Kelly, additional, De Cortada, Maiana, additional, Chavis, Lacy, additional, and Shannon, Jane, additional

Published
2024
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16. Social determinants of health rather than race impact health-related quality of life in 10-year-old children born extremely preterm

Author

Call, Catherine, primary, Oran, Ali, additional, O’Shea, T. Michael, additional, Jensen, Elizabeth T., additional, Frazier, Jean A., additional, Vaidya, Ruben, additional, Shenberger, Jeffrey, additional, Gogcu, Semsa, additional, Msall, Michael E., additional, Kim, Sohye, additional, Jalnapurkar, Isha, additional, Fry, Rebecca C., additional, and Singh, Rachana, additional

Published
2024
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17. The Impact of Erythropoietin on Short- and Long-Term Kidney-Related Outcomes in Neonates of Extremely Low Gestational Age. Results of a Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial

Author

Juul, Sandra E., Comstock, Bryan A., Wadhawan, Rajan, Mayock, Dennis E., Courtney, Sherry E., Robinson, Tonya, Ahmad, Kaashif A., Bendel-Stenzel, Ellen, Baserga, Mariana, LaGamma, Edmund F., Downey, L. Corbin, Rao, Raghavendra, Fahim, Nancy, Lampland, Andrea, Frantz, Ivan D., III, Khan, Janine Y., Weiss, Michael, Gilmore, Maureen M., Ohls, Robin, Srinivasan, Nishant, Perez, Jorge E., McKay, Victor, Vu, Phuong T., Heagerty, Patrick J., Thomas, Billy, Elhassan, Nahed, Mulkey, Sarah, Dydynski, Philip, Vijayamadhavan, Vivek K., Mulrooney, Neil, Yoder, Bradley, Kase, Jordan S., Check, Jennifer, Gogcu, Semsa, Osterholm, Erin, Ramel, Sara, Bendel, Catherine, Gale, Cheryl, George, Thomas, Georgieff, Michael, Gisslen, Tate, Guiang, Sixto, III, Hall, Anne, Johnson, Dana, Pfister, Katie, Podgorski, Heather, Roberts, Kari, Stepka, Erin, Engel, Melissa, Kamrath, Heidi, Scheurer, Johannah, Hanson, Angela, Satrom, Katherine, Pfister, Susan, Simones, Ann, Plummer, Erin, Zorn, Elizabeth, Martin, Camilia R., O'Reilly, Deirdre, Porta, Nicolas, Bazacliu, Catalina, Williams, Jonathan, Rajderkar, Dhanashree, Northington, Frances, Valdez, Raul Chavez, Beauman, Sandra, Saurabhkumar, Patel, Diaz-Barbosa, Magaly, Serize, Arturo, Jordan, Jorge, Ott, Debbie, Mora, Ariana Franco, Hedrick, Pamela, Flynn, Vicki, Silvia, Amy, Clopp, Bailey, Feltner, John B., Esposito, Isabella, Hauge, Stephanie, Nikirk, Samantha, Purnell, Andrea, Loy, Emilie, Sikes, Natalie, Mason, Melanie, McConnell, Jana, Brown, Tiffany, Harrison, Henry, Pearson, Denise, Drake, Tammy, Wright, Jocelyn, Walden, Debra, Guy, Annette, Nason, Jennifer, Talbot, Morgan, Lee, Kristen, Penny, Sarah, Boles, Terri, Drummond, Melanie, Kohlleppel, Katy, Kathen, Charmaine, Kaletka, Brian, Gonzales, Shania, Worwa, Cathy, Fisher, Molly, Richter, Tyler, Ginder, Alexander, Reich, Brixen, Rau, Carrie, Loertscher, Manndi, Bledsoe, Laura, McGrath, Kandace, Lewis, Kimberlee Weaver, Burnett, Jill, Schaefer, Susan, Bird, Karie, Giblin, Clare, Daly, Rita, Lanier, Kristi, Warden, Kelly, Wassenaar, Jenna, Ericksen, Jensina, Davern, Bridget, Osborne, Mary Pat, Gregorich, Brittany, Talele, Neha, Obregon, Evelyn, Ziyeh, Tiglath, Clarke, Molly, Wegner, Rachel E., Patel, Palak, Schau, Molly, Russow, Annamarie, Curry, Kelly, Sinnamon, Susan, Barnhart, Lisa, Parkinson, Charlamaine, Hanson, Mary, Kuan, Elizabeth, Lacy, Conra Backstrom, Galvis, Edshelee M., Bombino, Susana, Martinez, Denise, Bell, Suzi, Long, Corrie, Longa, Cathy, Westerveld, Michael, McConkey, Stacy, Hay, Anne, Natarajan, Niranjana, Gaudette, Shari, Cobb, Sarah, Sharp, Gregory, Schumacher, Elizabeth, Schuschke, Leslie, Frey, Charlotte, Fierro, Mario, Gilmore, Lois, Lundequam, Pamela, Hoekstra, Ronald, Ketko, Anastasia, Perdue, Nina, Cunningham, Sean, Stout, Kelly, Hall, Becky, Morshedzadeh, Galina, Ostrander, Betsy, Winter, Sarah, Cox, Lauren, Rainaldi, Matthew A., Hensley, Sarah, Morris, Melissa, Roberts, Dia, Tuttle, Melissa, Boys, Christopher, Hultgren, Solveig, Pierpont, Elizabeth I., George, Tom, King, Kelly E., Bataglia, Katherine, Neis, Cathy, Bergeron, Mark, Miller, Cristina, Accomando, Cara, Gavin, Jennifer Anne, Maczek, Elizabeth, Marakovitz, Susan, Knorr, Aimee, Smith, Vincent C., Stewart, Jane E., Weissbourd, Marie, deRegnier, Raye-Ann, Matoba, Nana, Heaton, Shelly C., Cascio, Erika M., Brady, Janet, Ghosh, Suman, Ditto, Jessica, Leppert, Mary, Lowe, Jean, Fuller, Janell, DuPont, Tara, Kloska, Pamela, Patel, Saurabh, Carbonell, Lauren, Patino-Fernandez, Anna Maria, de Lerma, Carmen, McDonough, Kelly, De Cortada, Maiana, Chavis, Lacy, Shannon, Jane, Konodi, Mark A., Nefcy, Christopher, Kuban, Karl C.K., Lowe, Jean R., O'Shea, T. Michael, Dighe, Manjiri, Richards, Todd, Shaw, Dennis W.W., Studholme, Colin, Traudt, Christopher M., Ballard, Roberta, Hartman, Adam, Janis, Scott, Ohls, T. Robin, O'Shea, Michael, Guillet, Ronnie, Ball, M. Bethany, Glass, Hannah, Saville, Ben, Schreiber, Michael, Askenazi, David J., Schmicker, Robert H., Brophy, Patrick, Goldstein, Stuart L., and Hingorani, Sangeeta

Published
2021
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18. Provision and availability of genomic medicine services in Level IV neonatal intensive care units

Author

Wojcik, Monica H., primary, Callahan, Katharine P., additional, Antoniou, Austin, additional, del Rosario, Maya C., additional, Brunelli, Luca, additional, ElHassan, Nahed O., additional, Gogcu, Semsa, additional, Murthy, Karna, additional, Rumpel, Jennifer A., additional, Wambach, Jennifer A., additional, Suhrie, Kristen, additional, Fishler, Kristen, additional, and Chaudhari, Bimal P., additional

Published
2023
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19. Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age

Author

Strobel, Katie, primary, Wood, Thomas, additional, Valentine, Gregory, additional, German, Kendell, additional, Gogcu, Semsa, additional, Hendrixson, D, additional, Kolnik, Sarah, additional, Law, Janessa, additional, Mayock, Dennis, additional, Comstock, Bryan, additional, Heagerty, Patrick, additional, and Juul, Sandra, additional

Published
2023
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22. Predicting 2-year neurodevelopmental outcomes in extremely preterm infants using graphical network and machine learning approaches

Author

Juul, Sandra E., primary, Wood, Thomas R., additional, German, Kendell, additional, Law, Janessa B., additional, Kolnik, Sarah E., additional, Puia-Dumitrescu, Mihai, additional, Mietzsch, Ulrike, additional, Gogcu, Semsa, additional, Comstock, Bryan A., additional, Li, Sijia, additional, Mayock, Dennis E., additional, Heagerty, Patrick J., additional, Wadhawan, Rajan, additional, Courtney, Sherry E., additional, Robinson, Tonya, additional, Ahmad, Kaashif A., additional, Bendel-Stenzel, Ellen, additional, Baserga, Mariana, additional, LaGamma, Edmund F., additional, Downey, L. Corbin, additional, Rao, Raghavendra, additional, Fahim, Nancy, additional, Lampland, Andrea, additional, Frantz, Ivan D., additional, Khan, Janine, additional, Weiss, Michael, additional, Gilmore, Maureen M., additional, Srinivasan, Nishant, additional, Perez, Jorge E., additional, and McKay, Victor, additional

Published
2023
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23. Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes

Author

O’Shea, T. Michael, primary, Register, Hannah M., additional, Yi, Joe X., additional, Jensen, Elizabeth T., additional, Joseph, Robert M., additional, Kuban, Karl C.K., additional, Frazier, Jean A., additional, Washburn, Lisa, additional, Belfort, Mandy, additional, South, Andrew M., additional, Santos, Hudson P., additional, Shenberger, Jeffrey, additional, Perrin, Eliana M., additional, Thompson, Amanda L., additional, Singh, Rachana, additional, Rollins, Julie, additional, Gogcu, Semsa, additional, Sanderson, Keia, additional, Wood, Charles, additional, and Fry, Rebecca C., additional

Published
2023
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25. CpG methylation patterns in placenta and neonatal blood are differentially associated with neonatal inflammation

Author

Eaves, Lauren A., primary, Enggasser, Adam E., additional, Camerota, Marie, additional, Gogcu, Semsa, additional, Gower, William A., additional, Hartwell, Hadley, additional, Jackson, Wesley M., additional, Jensen, Elizabeth, additional, Joseph, Robert M., additional, Marsit, Carmen J., additional, Roell, Kyle, additional, Santos, Hudson P., additional, Shenberger, Jeffrey S., additional, Smeester, Lisa, additional, Yanni, Diana, additional, Kuban, Karl C. K., additional, O’Shea, T. Michael, additional, and Fry, Rebecca C., additional

Published
2022
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26. Association between Term Equivalent Brain Magnetic Resonance Imaging and 2-Year Outcomes in Extremely Preterm Infants: A Report from the Preterm Erythropoietin Neuroprotection Trial Cohort

Author

Mayock, Dennis E., primary, Gogcu, Semsa, additional, Puia-Dumitrescu, Mihai, additional, Shaw, Dennis W.W., additional, Wright, Jason N., additional, Comstock, Bryan A., additional, Heagerty, Patrick J., additional, Juul, Sandra E., additional, Wadhawan, Rajan, additional, Courtney, Sherry E., additional, Robinson, Tonya, additional, Ahmad, Kaashif A., additional, Bendel-Stenzel, Ellen, additional, Baserga, Mariana, additional, LaGamma, Edmund F., additional, Downey, L. Corbin, additional, Rao, Raghavendra, additional, Fahim, Nancy, additional, Lampland, Andrea, additional, Frantz, Ivan D., additional, Khan, Janine, additional, Weiss, Michael, additional, Gilmore, Maureen M., additional, Ohls, Robin K., additional, Lowe, Jean, additional, Srinivasan, Nishant, additional, Perez, Jorge E., additional, McKay, Victor, additional, Thomas, Billy, additional, Elhassan, Nahed, additional, Mulkey, Sarah, additional, Vijayamadhavan, Vivek K., additional, Mulrooney, Neil, additional, Yoder, Bradley, additional, Kase, Jordan S., additional, Check, Jennifer, additional, Osterholm, Erin, additional, George, Thomas, additional, Georgieff, Michael, additional, Martin, Camilia R., additional, O'Reilly, Deirdre, additional, deRegnier, Raye-Ann, additional, Porta, Nicolas, additional, Bazacliu, Catalina, additional, Northington, Frances, additional, Valdez, Raul Chavez, additional, Saurabhkumar, Patel, additional, Diaz-Barbosa, Magaly, additional, Richards, Todd, additional, Feltner, John B., additional, Esposito, Isabella, additional, Hauge, Stephanie, additional, Nikirk, Samantha, additional, Silvia, Amy, additional, Clopp, Bailey, additional, Ott, Debbie, additional, Mora, Ariana Franco, additional, Hedrick, Pamela, additional, Flynn, Vicki, additional, Wyatt, Andrea, additional, Loy, Emilie, additional, Sikes, Natalie, additional, Mason, Melanie, additional, McConnell, Jana, additional, Brown, Tiffany, additional, Harrison, Henry, additional, Pearson, Denise, additional, Drake, Tammy, additional, Wright, Jocelyn, additional, Walden, Debra, additional, Guy, Annette, additional, Nason, Jennifer, additional, Talbot, Morgan, additional, Lee, Kristen, additional, Penny, Sarah, additional, Boles, Terri, additional, Drummond, Melanie, additional, Kohlleppel, Katy, additional, Kathen, Charmaine, additional, Kaletka, Brian, additional, Gonzales, Shania, additional, Worwa, Cathy, additional, Fisher, Molly, additional, Richter, Tyler, additional, Ginder, Alexander, additional, Reich, Brixen, additional, Rau, Carrie, additional, Loertscher, Manndi, additional, Cole, Laura, additional, McGrath, Kandace, additional, Lewis, Kimberlee Weaver, additional, Burnett, Jill, additional, Schaefer, Susan, additional, Bird, Karie, additional, Giblin, Clare, additional, Daly, Rita, additional, Lanier, Kristi, additional, Warden, Kelly, additional, Wassenaar, Jenna, additional, Ericksen, Jensina, additional, Davern, Bridget, additional, Osborne, Mary Pat, additional, Talele, Neha, additional, Obregon, Evelyn, additional, Ziyeh, Tiglath, additional, Clarke, Molly, additional, Wegner, Rachel E., additional, Patel, Palak, additional, Schau, Molly, additional, Russow, Annamarie, additional, Curry, Kelly, additional, Barnhart, Lisa, additional, Parkinson, Charlamaine, additional, Beauman, Sandra, additional, Hanson, Mary, additional, Kuan, Elizabeth, additional, Lacy, Conra Backstrom, additional, Galvis, Edshelee M., additional, Bombino, Susana, additional, Martinez, Denise, additional, Bell, Suzi, additional, Long, Corrie, additional, Nefcy, Christopher, additional, Konodi, Mark A., additional, Vu, Phuong T., additional, Hartman, Adam, additional, O'Shea, T. Michael, additional, Ballard, Roberta, additional, O'Shea, Mike, additional, Kuban, Karl, additional, and Widness, John, additional

Published
2021
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27. Intracranial Hemorrhage and 2-year Neurodevelopmental Outcomes in Extremely Preterm Infants

Author

Law, Janessa B, Wood, Thomas R., Gogcu, Semsa, Comstock, Bryan A., Dighe, Manjiri, Perez, Krystle, Puia-Dumitrescu, Mihai, Mayock, Dennis E., Heagerty, Patrick J., and Juul, Sandra E.

Subjects
Male, Infant, Newborn, Infant, Infant, Premature, Diseases, Severity of Illness Index, Article, Neurodevelopmental Disorders, Risk Factors, Child, Preschool, Infant, Extremely Premature, Prevalence, Humans, Female, Intracranial Hemorrhages, Ultrasonography
Abstract

OBJECTIVES: To determine the incidence, timing, progression, and risk factors for intracranial hemorrhage (ICH) in infants 24–0/7 to 27–6/7 weeks’ gestational age (GA), and to characterize the association between ICH and death or neurodevelopmental impairment (NDI) at 2 years corrected age (CA). STUDY DESIGN: Infants enrolled in the Preterm Erythropoietin Neuroprotection Trial had serial cranial ultrasounds performed on day 1, day 7–9, and 36-weeks postmenstrual age (PMA) to evaluate ICH. Potential risk factors for development of ICH were examined. Outcomes included death or severe NDI as well as Bayley Scales of Infant and Toddler Developmental, 3(rd) Edition (BSID-III) at 2-years CA. RESULTS: ICH was identified in 38% (n=339) of 883 enrolled infants. Multiple gestation and cesarean delivery reduced the risk of any ICH on day 1. Risk factors for development of bilateral Grade 2, or Grade 3 or 4 ICH at day 7–9 included any ICH at day 1, and two or more doses of prenatal steroids decreased risk. Bilateral Grade 2, Grade 3, or Grade 4 ICH at 36-weeks were associated with prior ICH at day 7–9. Bilateral Grade 2, any Grade 3, and any Grade 4 ICH at 7–9 days or 36-weeks PMA were associated with increased risk of death or severe NDI and lower BSID-III scores. CONCLUSION: Risk factors for ICH varied by timing of bleed. Bilateral and increasing grade of ICH were associated with death or NDI in infants born extremely preterm.

Published
2021

30. The Impact of Erythropoietin on Short- and Long-Term Kidney-Related Outcomes in Neonates of Extremely Low Gestational Age. Results of a Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial

Author

Askenazi, David J., primary, Heagerty, Patrick J., additional, Schmicker, Robert H., additional, Brophy, Patrick, additional, Juul, Sandra E., additional, Goldstein, Stuart L., additional, Hingorani, Sangeeta, additional, Comstock, Bryan A., additional, Wadhawan, Rajan, additional, Mayock, Dennis E., additional, Courtney, Sherry E., additional, Robinson, Tonya, additional, Ahmad, Kaashif A., additional, Bendel-Stenzel, Ellen, additional, Baserga, Mariana, additional, LaGamma, Edmund F., additional, Downey, L. Corbin, additional, Rao, Raghavendra, additional, Fahim, Nancy, additional, Lampland, Andrea, additional, Frantz, Ivan D., additional, Khan, Janine Y., additional, Weiss, Michael, additional, Gilmore, Maureen M., additional, Ohls, Robin, additional, Srinivasan, Nishant, additional, Perez, Jorge E., additional, McKay, Victor, additional, Vu, Phuong T., additional, Thomas, Billy, additional, Elhassan, Nahed, additional, Mulkey, Sarah, additional, Dydynski, Philip, additional, Vijayamadhavan, Vivek K., additional, Mulrooney, Neil, additional, Yoder, Bradley, additional, Kase, Jordan S., additional, Check, Jennifer, additional, Gogcu, Semsa, additional, Osterholm, Erin, additional, Ramel, Sara, additional, Bendel, Catherine, additional, Gale, Cheryl, additional, George, Thomas, additional, Georgieff, Michael, additional, Gisslen, Tate, additional, Guiang, Sixto, additional, Hall, Anne, additional, Johnson, Dana, additional, Pfister, Katie, additional, Podgorski, Heather, additional, Roberts, Kari, additional, Stepka, Erin, additional, Engel, Melissa, additional, Kamrath, Heidi, additional, Scheurer, Johannah, additional, Hanson, Angela, additional, Satrom, Katherine, additional, Pfister, Susan, additional, Simones, Ann, additional, Plummer, Erin, additional, Zorn, Elizabeth, additional, Martin, Camilia R., additional, O'Reilly, Deirdre, additional, Porta, Nicolas, additional, Bazacliu, Catalina, additional, Williams, Jonathan, additional, Rajderkar, Dhanashree, additional, Northington, Frances, additional, Valdez, Raul Chavez, additional, Beauman, Sandra, additional, Saurabhkumar, Patel, additional, Diaz-Barbosa, Magaly, additional, Serize, Arturo, additional, Jordan, Jorge, additional, Ott, Debbie, additional, Mora, Ariana Franco, additional, Hedrick, Pamela, additional, Flynn, Vicki, additional, Silvia, Amy, additional, Clopp, Bailey, additional, Feltner, John B., additional, Esposito, Isabella, additional, Hauge, Stephanie, additional, Nikirk, Samantha, additional, Purnell, Andrea, additional, Loy, Emilie, additional, Sikes, Natalie, additional, Mason, Melanie, additional, McConnell, Jana, additional, Brown, Tiffany, additional, Harrison, Henry, additional, Pearson, Denise, additional, Drake, Tammy, additional, Wright, Jocelyn, additional, Walden, Debra, additional, Guy, Annette, additional, Nason, Jennifer, additional, Talbot, Morgan, additional, Lee, Kristen, additional, Penny, Sarah, additional, Boles, Terri, additional, Drummond, Melanie, additional, Kohlleppel, Katy, additional, Kathen, Charmaine, additional, Kaletka, Brian, additional, Gonzales, Shania, additional, Worwa, Cathy, additional, Fisher, Molly, additional, Richter, Tyler, additional, Ginder, Alexander, additional, Reich, Brixen, additional, Rau, Carrie, additional, Loertscher, Manndi, additional, Bledsoe, Laura, additional, McGrath, Kandace, additional, Lewis, Kimberlee Weaver, additional, Burnett, Jill, additional, Schaefer, Susan, additional, Bird, Karie, additional, Giblin, Clare, additional, Daly, Rita, additional, Lanier, Kristi, additional, Warden, Kelly, additional, Wassenaar, Jenna, additional, Ericksen, Jensina, additional, Davern, Bridget, additional, Osborne, Mary Pat, additional, Gregorich, Brittany, additional, Talele, Neha, additional, Obregon, Evelyn, additional, Ziyeh, Tiglath, additional, Clarke, Molly, additional, Wegner, Rachel E., additional, Patel, Palak, additional, Schau, Molly, additional, Russow, Annamarie, additional, Curry, Kelly, additional, Sinnamon, Susan, additional, Barnhart, Lisa, additional, Parkinson, Charlamaine, additional, Hanson, Mary, additional, Kuan, Elizabeth, additional, Lacy, Conra Backstrom, additional, Galvis, Edshelee M., additional, Bombino, Susana, additional, Martinez, Denise, additional, Bell, Suzi, additional, Long, Corrie, additional, Longa, Cathy, additional, Westerveld, Michael, additional, McConkey, Stacy, additional, Hay, Anne, additional, Natarajan, Niranjana, additional, Gaudette, Shari, additional, Cobb, Sarah, additional, Sharp, Gregory, additional, Schumacher, Elizabeth, additional, Schuschke, Leslie, additional, Frey, Charlotte, additional, Fierro, Mario, additional, Gilmore, Lois, additional, Lundequam, Pamela, additional, Hoekstra, Ronald, additional, Ketko, Anastasia, additional, Perdue, Nina, additional, Cunningham, Sean, additional, Stout, Kelly, additional, Hall, Becky, additional, Morshedzadeh, Galina, additional, Ostrander, Betsy, additional, Winter, Sarah, additional, Cox, Lauren, additional, Rainaldi, Matthew A., additional, Hensley, Sarah, additional, Morris, Melissa, additional, Roberts, Dia, additional, Tuttle, Melissa, additional, Boys, Christopher, additional, Hultgren, Solveig, additional, Pierpont, Elizabeth I., additional, George, Tom, additional, King, Kelly E., additional, Bataglia, Katherine, additional, Neis, Cathy, additional, Bergeron, Mark, additional, Miller, Cristina, additional, Accomando, Cara, additional, Gavin, Jennifer Anne, additional, Maczek, Elizabeth, additional, Marakovitz, Susan, additional, Knorr, Aimee, additional, Smith, Vincent C., additional, Stewart, Jane E., additional, Weissbourd, Marie, additional, deRegnier, Raye-Ann, additional, Matoba, Nana, additional, Heaton, Shelly C., additional, Cascio, Erika M., additional, Brady, Janet, additional, Ghosh, Suman, additional, Ditto, Jessica, additional, Leppert, Mary, additional, Lowe, Jean, additional, Fuller, Janell, additional, DuPont, Tara, additional, Kloska, Pamela, additional, Patel, Saurabh, additional, Carbonell, Lauren, additional, Patino-Fernandez, Anna Maria, additional, de Lerma, Carmen, additional, McDonough, Kelly, additional, De Cortada, Maiana, additional, Chavis, Lacy, additional, Shannon, Jane, additional, Konodi, Mark A., additional, Nefcy, Christopher, additional, Kuban, Karl C.K., additional, Lowe, Jean R., additional, O'Shea, T. Michael, additional, Dighe, Manjiri, additional, Richards, Todd, additional, Shaw, Dennis W.W., additional, Studholme, Colin, additional, Traudt, Christopher M., additional, Ballard, Roberta, additional, Hartman, Adam, additional, Janis, Scott, additional, Ohls, T. Robin, additional, O'Shea, Michael, additional, Guillet, Ronnie, additional, Ball, M. Bethany, additional, Glass, Hannah, additional, Saville, Ben, additional, and Schreiber, Michael, additional

Published
2021
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33. Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes.

Author

O'Shea, T. Michael, Register, Hannah M., Yi, Joe X., Jensen, Elizabeth T., Joseph, Robert M., Kuban, Karl C.K., Frazier, Jean A., Washburn, Lisa, Belfort, Mandy, South, Andrew M., Santos, Hudson P., Shenberger, Jeffrey, Perrin, Eliana M., Thompson, Amanda L., Singh, Rachana, Rollins, Julie, Gogcu, Semsa, Sanderson, Keia, Wood, Charles, and Fry, Rebecca C.

Published
2023
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37. ADVANCE: a biomedical informatics approach to investigate acute kidney injury in infants.

Author

Rumpel JA, Perazzo S, Bona J, South AM, Harer MW, Liu D, Starr MC, Khattab M, Han R, Slagle C, Ciccia E, Najaf T, Gillen M, Harsono M, Nada A, Dwarakanath K, Gogcu S, Mohamed T, Stoops C, Bonachea E, Revenis M, Roberts J, Lenzini RM Jr, Debuyserie A, Joseph C, Murthy K, Ray P, Schootman M, and Nagel C

Abstract

Background: Acute kidney injury (AKI) occurs in up to half of infants admitted to the neonatal intensive care unit (NICU) and is associated with increased risks of death and more days of mechanical ventilation, hospitalization, and vasopressor drug support. Our objective was to build a granular relational database to study the impact that AKI has on infants admitted to Level-IV NICUs., Methods: A relational database was created by linking data from the Children's Hospitals Neonatal Database with AKI-focused data from electronic health records from 9 centers., Results: The current cohort consists of 24,870 infants with a median (IQR) gestational age of birth of 37 weeks (32 weeks, 39 weeks), and a median birth weight of 2.720 kg (1.750 kg, 3.310 kg). There was a male predominance with 14,214 (57%) males. In all, 2434 (9.8%) of the mothers were of Hispanic ethnicity. The maternal race breakdown of the cohort was as follows: 741 (3.0%) Asian, 5911 (24%) Black, and 14,945 (60%) White. Overall mortality was 5.8%., Conclusion: The ADVANCE relational database is an innovative research tool to rigorously study the epidemiology of AKI in a large national cohort of infants admitted to Level-IV NICUs involved in the Children's Hospital Neonatal Consortium., Impact: We used a biomedical informatics approach to build a relational database to study acute kidney injury in infants. We highlight our methodology linking Children's Hospital Neonatal Consortium and electronic health record data from nine neonatal intensive care units. The ADVANCE relational database is a granular and innovative research tool to study risk factors and in-hospital outcomes of acute kidney injury and mortality in a vulnerable patient population., (© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)

Published
2024
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38. Advocating for the inclusion of kidney health outcomes in neonatal research: best practice recommendations by the Neonatal Kidney Collaborative.

Author

Reidy KJ, Guillet R, Selewski DT, Defreitas M, Stone S, Starr MC, Harer MW, Todurkar N, Vuong KT, Gogcu S, Askenazi D, Tipple TE, and Charlton JR

Abstract

Acute kidney injury (AKI) occurs in nearly 30% of sick neonates. Chronic kidney disease (CKD) can be detected in certain populations of sick neonates as early as 2 years. AKI is often part of a multisystem syndrome that negatively impacts developing organs resulting in short- and long-term pulmonary, neurodevelopmental, and cardiovascular morbidities. It is critical to incorporate kidney-related data into neonatal clinical trials in a uniform manner to better understand how neonatal AKI or CKD could affect an outcome of interest. Here, we provide expert opinion recommendations and rationales to support the inclusion of short- and long-term neonatal kidney outcomes using a tiered approach based on study design: (1) observational studies (prospective or retrospective) limited to data available within a center's standard practice, (2) observational studies involving prospective data collection where prespecified kidney outcomes are included in the design, (3) interventional studies with non-nephrotoxic agents, and (4) interventional studies with known nephrotoxic agents. We also provide recommendations for biospecimen collection to facilitate ancillary kidney specific research initiatives. This approach balances the costs of AKI and CKD ascertainment with knowledge gained. We advocate that kidney outcomes be included routinely in neonatal clinical study design. Consistent incorporation of kidney outcomes across studies will increase our knowledge of neonatal morbidity., (© 2024. The Author(s).)

Published
2024
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39. Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.

Author

Emmanuel C, Oran A, Jensen ET, Fichorova RN, Gower WA, Perrin EM, Sanderson K, South AM, Gogcu S, Shenberger J, Singh R, Makker K, Thompson AL, Santos H, Fry RC, and O'Shea TM

Abstract

Background: Asthma and obesity are frequent outcomes among individuals born extremely preterm and are associated with decreased lifespan. Neonatal inflammation is associated with chronic neurodevelopmental disorders; however, it is less studied in association with other later childhood chronic disorders in this population., Methods: Fourteen hospitals in 5 U.S. states enrolled 1506 infants born before 28 weeks of gestation in the Extremely Low Gestational Age Newborn cohort in 2004-2014. Neonatal blood spots were collected on postnatal days 1, 7, 14, 21, and 28, and used to measure 14 inflammation-related proteins. Associations were evaluated between high (top quartile) levels of proteins and two chronic health disorders at ages 10 and 15 years: physician-diagnosed asthma and obesity (body mass index ≥95th percentile)., Results: Few associations were found between high levels of 14 inflammation-related proteins, either on a single day or on multiple days, and either asthma or obesity. Similarly, few associations were found in analyses stratified by sex or presence/absence of prenatal inflammation., Conclusions: In extremely preterm newborns, systemic elevations of inflammation-related proteins during the neonatal period were not associated with childhood asthma and obesity outcomes at 10 or 15 years of age., Impact: In the large multi-center Extremely Low Gestational Age Newborn (ELGAN) cohort, sustained elevation of neonatal levels of inflammation-related proteins was not consistently associated with asthma or obesity outcomes at 10 or 15 years of age. This finding contrasts with reported associations of perinatal inflammation with obesity at 2 years and neurodevelopmental disorders at 2-15 years in the ELGANs, suggesting that unlike neurodevelopment, peripubertal obesity and asthma may be driven by later childhood exposures. Future research on perinatal mechanisms of childhood asthma and obesity should account for both fetal and later exposures and pathways in addition to inflammation at birth., (© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)

Published
2024
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40. Retinopathy of prematurity and neurodevelopmental outcome and quality of life at 10 years of age.

Author

Sriram S, Jensen E, Msall M, Yi J, Zhabotynsky V, Joseph R, Kuban K, Frazier J, Hooper S, Santos H, Gogcu S, Shenberger J, Fry R, and O'Shea T

Abstract

Objective: In a cohort of 10-year-old children born extremely preterm, we evaluated the hypothesis that increasing severity of retinopathy of prematurity (ROP) is associated with increasing frequency of unfavorable neurodevelopmental and quality of life outcomes., Study Design: Study participants were classified according to the severity of ROP. At 10 years of age, their neurocognitive abilities, academic achievement, and gross motor function were assessed, and they were evaluated for autism spectrum disorder, anxiety, depression, and quality of life., Results: After adjustment for sample attrition and confounders, only the association with lower quality of life persisted. Increasing severity of visual impairment was associated with worse neurodevelopmental outcomes and lower quality of life., Conclusion: Among extremely preterm children, severity of visual impairment, but not severity of ROP, was associated with adverse neurodevelopmental outcomes at 10 years of age. Both severe ROP and more severe visual impairment were associated with lower quality of life., Competing Interests: Declarations Conflicts of interest Disclosures: The authors have no conflicts of interest to disclose.

Published
2024
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41. Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age.

Author

Strobel K, Wood T, Valentine G, German K, Gogcu S, Hendrixson D, Kolnik S, Law J, Mayock D, Comstock B, Heagerty P, and Juul S

Abstract

Introduction: The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown., Methods: In a secondary analysis of a preterm cohort, changes in anthropometric z-scores were examined between birth and hospital discharge, and from discharge to 2 years. The 2-year evaluation included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist (CBCL)., Results: Among 629 infants, accelerated linear growth from birth to discharge was associated with higher BSID-III cognitive scores (+ 3.2 points [IQR 0.02, 6.4]) while in-hospital GF was not associated with any outcomes. Infants with weight GF after discharge had lower BSID-III motor scores (-3.1 points [-5.9, -0.2]). Infants with accelerated weight growth after discharge had increased odds of behavioral problems on the CBCL (aOR 1.9 [1.03, 3.5])., Discussion: In-hospital and post-hospitalization growth metrics are modestly associated with neurodevelopmental outcomes with length gains apparently most beneficial., Competing Interests: Conflicts of Interest: None of the authors report any conflicts of interest.

Published
2023
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42. Predicting 2-year neurodevelopmental outcomes in extremely preterm infants using graphical network and machine learning approaches.

Author

Juul SE, Wood TR, German K, Law JB, Kolnik SE, Puia-Dumitrescu M, Mietzsch U, Gogcu S, Comstock BA, Li S, Mayock DE, and Heagerty PJ

Abstract

Background: Infants born extremely preterm (<28 weeks' gestation) are at high risk of neurodevelopmental impairment (NDI) with 50% of survivors showing moderate or severe NDI when at 2 years of age. We sought to develop novel models by which to predict neurodevelopmental outcomes, hypothesizing that combining baseline characteristics at birth with medical care and environmental exposures would produce the most accurate model., Methods: Using a prospective database of 692 infants from the Preterm Epo Neuroprotection (PENUT) Trial, which was carried out between December 2013 and September 2016, we developed three predictive algorithms of increasing complexity using a Bayesian Additive Regression Trees (BART) machine learning approach to predict both NDI and continuous Bayley Scales of Infant and Toddler Development 3rd ed subscales at 2 year follow-up using: 1) the 5 variables used in the National Institute of Child Health and Human Development (NICHD) Extremely Preterm Birth Outcomes Tool, 2) 21 variables associated with outcomes in extremely preterm (EP) infants, and 3) a hypothesis-free approach using 133 potential variables available for infants in the PENUT database., Findings: The NICHD 5-variable model predicted 3-4% of the variance in the Bayley subscale scores, and predicted NDI with an area under the receiver operator curve (AUROC, 95% CI) of 0.62 (0.56-0.69). Accuracy increased to 12-20% of variance explained and an AUROC of 0.77 (0.72-0.83) when using the 21 pre-selected clinical variables. Hypothesis-free variable selection using BART resulted in models that explained 20-31% of Bayley subscale scores and AUROC of 0.87 (0.83-0.91) for severe NDI, with good calibration across the range of outcome predictions. However, even with the most accurate models, the average prediction error for the Bayley subscale predictions was around 14-15 points, leading to wide prediction intervals. Higher total transfusion volume was the most important predictor of severe NDI and lower Bayley scores across all subscales., Interpretation: While the machine learning BART approach meaningfully improved predictive accuracy above a widely used prediction tool (NICHD) as well as a model utilizing NDI-associated clinical characteristics, the average error remained approximately 1 standard deviation on either side of the true value. Although dichotomous NDI prediction using BART was more accurate than has been previously reported, and certain clinical variables such as transfusion exposure were meaningfully predictive of outcomes, our results emphasize the fact that the field is still not able to accurately predict the results of complex long-term assessments such as Bayley subscales in infants born EP even when using rich datasets and advanced analytic methods. This highlights the ongoing need for long-term follow-up of all EP infants., Funding: Supported by the National Institute of Neurological Disorders and StrokeU01NS077953 and U01NS077955., Competing Interests: S.E.J. declares receiving royalties from editing Avery's Diseases of the Newborn. S.E.J., B.A.C., D.E.M., and P.J.H. received salary support as part of funding for the PENUT trial. All other authors declare that they have no relevant conflicts of interest., (© 2022 The Author(s).)

Published
2022
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