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4. Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma

Author

Chevallier, Patrick, Wigmore, Stephen, Newhook, Timothy, Vauthey, Jean-Nicolas, Memeo, Riccardo, Dasari, Bobby VM., Braunwarth, Eva, Aldrighetti, Luca, Andorrà, Esteban Cugat, Arntz, Pieter, Arslan, Bulent, van Baardewijk, Laurens, Baclija, Ivan, Ball, Chad, Barbier, Louise, Bednarsch, Jan, Bemelmans, Marc, Bent, Clare, van den Bergh, Frans, Billingsley, Kevin, Binkert, Christoph, Björnsson, Bergthor, de Boer, Marieke T., Bokkers, Reinoud P.H., de Boo, Diederick, Garcia Borobia, Francisco Javier, Braat, Dries, Breen, David, Breitenstein, Stefan, Brousseau, Karine, Bruijnen, Ruther, Bruners, Philipp, Bruns, Christiane, Bunck, Alexander, Burgmans, Mark, Cappelli, Alberta, Carling, Ulrik, de Carvalho, Luis Abreu, Cha, Charles, Chan, Benjamin, Chand, Belinda, Chapelle, Thiery, De Cobelli, Franceso, Coubeau, Laurent, Criado, Eva, Croagh, Daniel, D'Hondt, Mathieu, van Dam, Ronald, Damink, Steven Olde, Davis, Rob, Delle, Martin, Denys, Alban, Deprez, Fabrice, Detry, Olivier, Dewulf, Maxime, Dili, Alexandra, Dixon, Matthew, Díaz-Nieto, Rafael, Erdmann, Joris I., Fernando, Rukshan, Font, Jaume Codina, Fouraschen, Suomi, François, Olivier, Fretland, Åsmund A., Fundora, Yilian, Gadani, Sameer, Gallinger, Steven, Geleabert, Alexandra, Gerard, Laurent, Giménez, Josep Guitart, Gobardhan, Paul, Goffette, Pierre, Grochola, Lukasz Filip, Gruenberger, Thomas, Grünhagen, Dirk, Guiliante, Felice, Gómez, Fernando, Hagendoorn, Jeroen, Hammond, John, Heijmans, Margot, Heil, Jan, Heise, Daniel, Laurens Hermie, Herrero, Eric, Hess, Gebriel, Heye, Sam, Hoffmann, Martin, Iezzi, Roberto, Imani, Farshad, James, Sinead, Jardinet, Thomas, Joshi, Kunal, Jovine, Elio, Kalil, Jennifer, Karanicolas, Paul, Kazemier, Geert, Kern, Lars, Kingham, Peter, Klass, Darren, Koerkamp, Bas Groot, Kollmar, Otto, Korenblik, Remon, Choon Kwon, Céline Lambrecht, Sven Lang, Laura-Ann, Leclercq, Wouter, van der Leij, Christiaan, Lindsay, Richard, Lopez-Ben, Santiago, Lucidi, Valerio, López, Jordi Navinés, Macdonald, Andrew, Madoff, David C., Markose, George, Maroune, Gilbert, Martel, Guillaume, Martin, Ernesto Santos, Mehrzad, Homoyon, Meijerink, Martijn, Melloul, Emmanuel, Messaoudi, Nouredin, Metrakos, Peter, Modi, Sachin, Montanari, Nicola, Moragues, Jaume Sampere, Mujoomdar, Amol, Neumann, Ulf, Oor, Jelmer, Pappas, Patroklos, Pieterman, Kay, Primrose, John, Qu, Xudong, Ratti, Francesca, Ridouani, Fourat, Borel Rinkes, Inne H.M., Casellas i Robert, Margarida, Ross, Steffen, Ruo, Leyo, Ryan, Stephen, Salik, Aysun, Sandström, Per, Santol, Jonas, Sarría, Luis, Schaarschmidt, Benedikt, Schadde, Erik, Schiesser, Marc, Schmelzle, Moritz, Seeger, Nico, Segedi, Maja, Serenari, Matteo, Gregory Sergeant, Serrablo, Alejandro, Simon, Sorina, Skaro, Anton, Smits, Maarten, Smits, Jens, Snitzbauer, Andreas, Soonawalla, Zahir, Sparrelid, Ernesto, Spuentrup, Elmar, Stavrou, Gregor, Sutcliffe, Robert, Swijnenburg, Rutger-Jan, Tancredi, Ilario, Tasse, Jordan C., Tschögl, Madita, Udupa, Venkatesha, Valenti, David A., Vass, David, van der Velden, Ariadne Lisa, Vogl, Thomas, Wacker, Frank, Wang, Xiaoying, Weitz, Jürgen, White, Steven, Widyaningsih, Rizky, De Wispelaere, Jean-François, Zijlstra, Ijsbrand, Chau, Steven, James, Sinéad, Abreu de Carvalho, Luis, Erdmann, Joris, Hermie, Laurens, and van Dam, Ronald M.

Published
2024
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5. Inhaled drug delivery: a randomized study in intubated patients with healthy lungs

Author

Dugernier, Jonathan, Le Pennec, Déborah, Maerckx, Guillaume, Allimonnier, Laurine, Hesse, Michel, Castanares-Zapatero, Diego, Depoortere, Virginie, Vecellio, Laurent, Reychler, Gregory, Michotte, Jean-Bernard, Goffette, Pierre, Docquier, Marie-Agnes, Raftopoulos, Christian, Jamar, François, Laterre, Pierre-François, Ehrmann, Stephan, and Wittebole, Xavier

Published
2023
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8. Multicenter, retrospective analysis of endovascular treatment for acute ischemic stroke in nonagenarians

Author

Janssen, Helena, Nannoni, Stefania, Francois, Olivier, Dewaele, Tom, De Blauwe, Sofie, Vanhooren, Geert, Ghekiere, Johan, Kager, Joost, Peeters, André, Goffette, Pierre, Hammer, Frank, Duprez, Thierry, Demeestere, Jelle, Lemmens, Robin, Cornelissen, Sandra, Heye, Sam, Yperzeele, Laetitia, Baar, Ingrid, Voormolen, Maurits, Van der Zijden, Thijs, Mondelaers, Annelies, Andersson, Tommy, Pottel, Hans, Odier, Céline, Karkri, Fatine, Michel, Patrik, and Vanacker, Peter

Published
2020
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13. Innovations 2022 en chirurgie hépato-bilio-pancréatique

Author

Marique, Lancelot, De Cuyper, Astrid, Annet, Laurence, Dragean, Cristina Anca, Goffette, Pierre, Hoton, Delphine, Lhommel, Renaud, Van Ooteghem, Geneviève, Borbath, Ivan, Hubert, Catherine, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Service de radiologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de médecine nucléaire, UCL - (SLuc) Service de radiothérapie oncologique, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service d'hépato-gastro-entérologie, and UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation

Subjects
Adénocarcinome, Pancréas, Réponse pathologique complète, Traitement néoadjuvant, Chirurgie, Chimiothérapie, Cancer, Radiothérapie
Abstract

Innovations dans la prise en charge de l’adénocarcinome pancréatique « limite résécable » ou « localement avancé », en 2022 : que retenir ? L’année 2022 a été riche en innovations dans la prise en charge de l’adénocarcinome du pancréas borderline ou localement avancé et offre de nouvelles opportunités de traitements multimodaux aux Cliniques universitaires Saint-Luc. Nous vous illustrons ici par deux histoires cliniques, l’importance de la prise en charge pluridisciplinaire pour ce type de patients. Nous vous détaillons ensuite, par spécialité, les innovations et spécificités propres à chacun, dont l’expertise est capitale au sein du groupe.

Published
2023

17. Utility of A2L2score in acute ischemic stroke patient triage: the “H.uni” experience

Author

Scoppettuolo, Pasquale, Raymackers, Jean-Marc, Rutgers, Matthieu Pierre, Poma, Jean-François, Goffette, Pierre, Hammer, Frank, and Peeters, André

Abstract

Background and aims: Two or more National Institutes of Health Stroke Scale (NIHSS) points on each motor items (A2L2score) have shown good accuracy in predicting large vessel occlusion (LVO) in the prehospital setting of acute ischemic stroke (AIS) care. We aimed to study this score for LVO prediction in our stroke network and predictors of poor outcome (PO) after mechanical thrombectomy (MT). Methods: From our Safe Implementation of Thrombolysis in Stroke (SITS) registry including patients receiving reperfusion therapy for AIS, we retrospectively computed the A2L2score from the admission NIHSS to test the diagnostic accuracy for LVO prediction. Multivariable analysis for independent predictors of LVO on the entire cohort and PO from patients with LVO were performed. Results: From the 853 patients with AIS (67% LVO), A2L2was positive in 52%. A2L2score (Odds ratio [OR] 4.6;95%CI 3.36-6.34), smoking (OR 2.1;95%CI 1.14-3.85), atrial fibrillation (OR 1.6;95%CI1.1-2.4) and younger age (OR 0.98;95%CI0.97-0.99) were independent predictors of LVO. A2L2score showed 82%/49% positive/negative predictive values with 66% accuracy (64%/72% sensitivity/specificity) for LVO prediction. Age (OR 1.05;95%CI 1.03-1.07), atrial fibrillation (OR 4.85;95%CI 1.5-15.7), diabetes (OR 2.62;95% CI 1.14-6.05), dyslipidemia (OR 2;95% CI 1.04-3.87), A2L2score (OR 2.68;95% CI 1.45-4.98), longer onset-to-groin time (OR 1.003;95% CI 1.001-1.01), MT procedure (OR 1.01;95%CI 1.003-1.02) general anaesthesia (OR 2.06;95% CI 1.1-3.83) and symptomatic intracranial hemorrhage (OR 12.10;95%CI 3.15-46.44) were independent predictors of PO. Conclusions: A2L2score independently predicted LVO and PO after MT. Patient characteristics and procedural factors determined PO of LVO patients after MT.

Published
2024
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20. Interim analysis of the phase II AVETUXIRI trial: Avelumab combined with cetuximab and irinotecan for treatment of refractory microsatellite stable (MSS) metastatic colorectal cancer (mCRC).

Author

Huyghe, Nicolas, primary, De Cuyper, Astrid, additional, Sinapi, Isabelle, additional, Vempalli, Fazulur Rehaman, additional, Rinchai, Darawan, additional, Beyaert, Simon, additional, Verstraelen, Eleonore, additional, Goffette, Pierre, additional, Ghaye, Benoît, additional, Gilet, Mélanie, additional, Van Maanen, Aline, additional, Castella, Marie-Laure, additional, Mlecnik, Bernhard, additional, Carrasco, Javier, additional, Galon, Jerome, additional, Bedognetti, Davide, additional, and Van Den Eynde, Marc, additional

Published
2022
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21. Meso-Rex bypass for the management of extrahepatic portal vein obstruction in adults (with video).

Author

UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de radiologie, Brichard, Martin, Iesari, Samuele, Lerut, Jan, Reding, Raymond, Goffette, Pierre, Coubeau, Laurent, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de radiologie, Brichard, Martin, Iesari, Samuele, Lerut, Jan, Reding, Raymond, Goffette, Pierre, and Coubeau, Laurent

Abstract

Extrahepatic portal vein obstruction (EHPVO) results in severe portal hypertension (PHT) leading to severely compromised quality of life. Often, pharmacological and endoscopic management are unable to solve this problem. Restoring hepatic portal flow using meso-Rex bypass (MRB) may solve it. This procedure, uncommon in adult patients, is considered the treatment of choice for EHPVO in children. From 1997 to 2018, 8 male and 6 female adults, with a median age of 51 years (range 22-66) underwent MRB procedure for EHPVO at the University Hospitals Saint-Luc in Brussels, Belgium. Symptoms of PHT were life altering in all but one patient and consisted of repetitive gastro-intestinal bleedings, sepsis due to portal biliopathy, and/or severe abdominal discomfort. The surgical technique consisted in interposition of a free venous graft or of a prosthetic graft between the superior mesenteric vein and the Rex recess of the left portal vein. Median operative time was 500 min (range 300-730). Median follow-up duration was 22 months (range 2-169). One patient died due to hemorrhagic shock following percutaneous transluminal intervention for early graft thrombosis. Major morbidity, defined as Clavien-Dindo score ≥ III, was 35.7% (5/14). Shunt patency at last follow-up was 64.3% (9/14): 85.7% (6/7) of pure venous grafts and only 42.9% (3/7) of prosthetic graft. Symptom relief was achieved in 85.7% (12/14) who became asymptomatic after MRB. Adult EHPVO represents a difficult clinical condition that leads to severely compromised quality of life and possible life-threatening complications. In such patients, MRB represents the only and last resort to restore physiological portal vein flow. Although successful in a majority of patients, this procedure is associated with major morbidity and mortality and should be done in tertiary centers experienced with vascular liver surgery to get the best results.

Published
2022

22. Hepatobiliary and Pancreatic: An uncommon cause of portal hypertension.

Author

UCL - (SLuc) Service de gastro-entérologie, UCL - (SLuc) Service de radiologie, Binet, Quentin, Annet, Laurence, Danse, Etienne, Goffette, Pierre, Lanthier, Nicolas, UCL - (SLuc) Service de gastro-entérologie, UCL - (SLuc) Service de radiologie, Binet, Quentin, Annet, Laurence, Danse, Etienne, Goffette, Pierre, and Lanthier, Nicolas

Published
2022

23. Adult-onset nesidioblastosis: a challenging diagnosis revealed by glucagon-like-peptide-1 receptor imaging.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service d'endocrinologie et de nutrition, Demartin, Sophie, Goffette, Pierre, Christ, Emanuel, Freitag, Martin T, Maiter, Dominique, Furnica, Raluca-Maria, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service d'endocrinologie et de nutrition, Demartin, Sophie, Goffette, Pierre, Christ, Emanuel, Freitag, Martin T, Maiter, Dominique, and Furnica, Raluca-Maria

Abstract

A 52-year-old female presented with recurrent episodes of fasting or post-absorptive hypoglycemia. A 72-h fasting test confirmed endogenous hyperinsulinemia. Conventional imaging was unremarkable. Selective pancreatic arterial calcium stimulation and hepatic venous sampling showed a maximum calcium-stimulated insulin concentration from several pancreatic areas, mainly the proximal splenic artery and the proximal gastroduodenal artery, suggesting the presence of one or more occult insulinoma(s) in the region of the pancreatic body. 68Ga-DOTA-exendin-4 PET/CT showed however generalized increased uptake in the pancreas and a diagnosis of nesidioblastosis was therefore suspected. The patient has been since successfully treated with dietetic measures and diazoxide. Treatment efficacy was confirmed by a flash glucose monitoring system with a follow-up of 7 months. Learning points: Adult nesidioblastosis is a rare cause of endogenous hyperinsulinemic hypoglycemia. The distinction between insulinoma and nesidioblastosis is essential since the therapeutic strategies are different. 68Ga-DOTA-exendin-4 PET/CT emerges as a new noninvasive diagnostic tool for the localization of an endogenous source of hyperinsulinemic hypoglycemia. Medical management with dietetic measures and diazoxide need to be considered as a valuable option to treat patients with adult nesidioblastosis. Flash glucose monitoring system is helpful for the evaluation of treatment efficacy.

Published
2022

24. Enrichment of Rare Variants in Loeys-Dietz Syndrome Genes in Spontaneous Coronary Artery Dissection but Not in Severe Fibromuscular Dysplasia

Author

Verstraeten, Aline, Perik, Melanie H.A.M., Baranowska, Anna A., Meester, Josephina A.N., Van Den Heuvel, Lotte, Bastianen, Jarl, Kempers, Marlies, Krapels, Ingrid P.C., Maas, Angela, Rideout, Andrea, Vandersteen, Anthony, Sobey, Glenda, Johnson, Diana, Fransen, Erik, Ghali, Neeti, Webb, Tom, Al-Hussaini, Abtehale, de Leeuw, Peter, Delmotte, Philippe, Lopez-Sublet, Marilucy, Pappaccogli, Marco, Sprynger, Muriel, Toubiana, Laurent, Van Laer, Lut, Van Dijk, Fleur S., Vikkula, Miikka, Samani, Nilesh J., Persu, Alexandre, Adlam, David, Loeys, Bart, Beauloye, Christophe, Chenu, Patrick, Hammer, Frank, Goffette, Pierre, Astarci, Parla, Peeters, André, Verhelst, Robert, Van der Niepen, Patricia, Van Tussenbroek, Frank, De Backer, Tine, Gevaert, Sofie, Hemelsoet, Dimitri, Defreyne, Luc, Heuten, Hilde, Yperzeele, Laetitia, Van der Zijden, Thijs, Lengelé, Jean-Philippe, Krzesinski, Jean-Marie, Verhamme, Peter, Vanassche, Thomas, Scoppettuolo, Pasquale, Wautrecht, Jean-Claude, Jelaković, Bojan, Dika, Zivka, Maria Bruno, Rosa, Taddei, Stefano, Romanini, Caterina, Petrucci, Ilaria, Rabbia, Franco, Di Monaco, Silvia, Paolo Rossi, Gian, Lerco, Silvia, Minuz, Pietro, Mansueto, Giancarlo, De Marchi, Sergio, Marcon, Denise, Kroon, Bram, Spiering, Wilko, van den Born, Bert-Jan, Poch, Esteban, Montagud-Marrahi, Enrique, Molina, Alicia, Guillen, Elena, Burrel, Marta, Wuerzner, Gregor, Mazzolai, Lucia, Buso, Giacomo, European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI), [missing], MUMC+: DA KG Polikliniek (9), RS: Carim - H02 Cardiomyopathy, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: Carim - V02 Hypertension and target organ damage, Interne Geneeskunde, MUMC+: MA Alg Interne Geneeskunde (9), European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI), Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/GEHU - Génétique, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, and UCL - (SLuc) Service de pathologie cardiovasculaire

Subjects
Pathology, medicine.medical_specialty, coronary artery, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], fibromuscular dysplasia, Fibromuscular dysplasia, 030204 cardiovascular system & hematology, Loeys–Dietz syndrome, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Severe Fibromuscular Dysplasia, Physiology (medical), medicine, Medicine and Health Sciences, Pharmacology (medical), genetics, Artery dissection, 030304 developmental biology, Medicine(all), 0303 health sciences, business.industry, medicine.disease, Loeys-Dietz syndrome, Nephrology, cardiovascular system, Human medicine, business, Cardiology and Cardiovascular Medicine, coronary artery disease, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Spontaneous coronary artery dissection (SCAD) is a prime cause of acute myocardial infarction in women < 50 years. Fibromuscular dysplasia (FMD) is present in 17% to 86% of patients with SCAD.1 In contrast, the prevalence of SCAD in FMD cohorts is

Published
2020

27. CIRSE Vascular Closure Device Registry

Author

Reekers, Jim A., Müller-Hülsbeck, Stefan, Libicher, Martin, Atar, Eli, Trentmann, Jens, Goffette, Pierre, Borggrefe, Jan, Zeleňák, Kamil, Hooijboer, Pieter, and Belli, Anna-Maria

Published
2011
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30. Male Sex Is Associated With Cervical Artery Dissection in Patients With Fibromuscular Dysplasia

Author

Arnaud, Charlotte, primary, Boulanger, Marion, additional, Lorthioir, Aurélien, additional, Amar, Laurence, additional, Azarine, Arshid, additional, Boyer, Louis, additional, Chatellier, Gilles, additional, Di Monaco, Silvia, additional, Jeunemaitre, Xavier, additional, Kastler, Adrian, additional, Mousseaux, Elie, additional, Oppenheim, Catherine, additional, Thony, Frédéric, additional, Persu, Alexandre, additional, Olin, Jeffrey W., additional, Azizi, Michel, additional, Touzé, Emmanuel, additional, Chedid, Antoine, additional, Fiquet, Béatrice, additional, Plouin, Pierre‐François, additional, Baguet, Jean‐Philippe, additional, Ormezzano, Olivier, additional, Silhol, François, additional, Bodiguel, Eric, additional, Domigo, Valérie, additional, Pasquini, Marta, additional, Trystram, Denis, additional, Clavelou, Pierre, additional, Chamontin, Bernard, additional, Duly‐Bouhanick, Béatrice, additional, Hénon, Hilde, additional, Mounier‐Vehier, Claire, additional, Astarci, Parla, additional, Goffette, Pierre, additional, Hammer, Frank, additional, Lengelé, Jean‐Philippe, additional, Severino, Francesca, additional, Verhelst, Robert, additional, Le Hello, Claire, additional, Gosse, Philippe, additional, Hervé, Dominique, additional, Pico, Fernando, additional, Kessler, Michèle, additional, Rossignol, Patrick, additional, Sanson, Yves, additional, Zuber, Mathieu, additional, Mazighi, Mikael, additional, and Alamowitch, Sonia, additional

Published
2021
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31. Antireflux catheter improves tumor targeting in liver radioembolization with resin microspheres.

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de médecine nucléaire, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Centre du cancer, D'Abadie, Philippe, Walrand, Stephan, Goffette, Pierre, Amini, Nadia, van Maanen, Aline, Lhommel, Renaud, Jamar, François, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de médecine nucléaire, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Centre du cancer, D'Abadie, Philippe, Walrand, Stephan, Goffette, Pierre, Amini, Nadia, van Maanen, Aline, Lhommel, Renaud, and Jamar, François

Abstract

PURPOSE: We aimed to determine whether antireflux (ARC) catheter may result in better tumor targeting in liver radioembolization using 90Y-resin microspheres. METHODS: Patients treated with resin microspheres for hepatocellular carcinoma (HCC) and secondary liver malignancies were retrospectively analyzed. All patients underwent a 99mTc-macroaggregated albumin (99mTc-MAA) single photon emission computed tomography (SPECT) following the planning arteriography with a conventional end-hole catheter. For 90Y-microspheres injection, two groups were defined depending on the type of catheter used: an ARC group (n=38) and a control group treated with a conventional end-hole catheter (n=23). 90Y positron emission tomography computed tomography (PET/CT) was performed after the therapeutic arteriography. The choice of the catheter was not randomized, but left to the choice of the interventional radiologist. 99mTc-MAA SPECT and 90Y PET/CT were co-registered with the baseline imaging to determine a tumor to normal liver ratio (T/NL[MAA or 90Y]) and tumor dose (TD[MAA or 90Y]) for the planning and therapy. RESULTS: Overall, 38 patients (115 lesions) and 23 patients (75 lesions) were analyzed in the ARC and control groups, respectively. In the ARC group, T/NL90Y and TD90Y were significantly higher than T/NLMAA and TDMAA. Median (IQR) T/NL90Y was 2.16 (2.15) versus 1.74 (1.43) for T/NLMAA (p < 0.001). Median (IQR) TD90Y was 90.96 Gy (98.31 Gy) versus 73.72 Gy (63.82 Gy) for TDMAA (p < 0.001). In this group, the differences were highly significant for neuroendocrine metastases (NEM) and HCC and less significant for colorectal metastases (CRM). In the control group, no significant differences were demonstrated. CONCLUSION: The use of an ARC significantly improves tumor deposition in liver radioembolization with resin microspheres.

Published
2021

32. About the diagnosis and treatment of suspected bile duct pathology in Roux-en-Y liver transplant patients

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (MGD) Service de gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Moreels, Tom, Monino, Laurent, Dahlqvist, Caroline, Delire, B., Coubeau, Laurent, Ciccarelli, Olga, Bonaccorsi Riani, E., Goffette, Pierre, Sokal, Etienne, Piessevaux, P, Belgian Week of Gastroenterology: the digital experience in 2021, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (MGD) Service de gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Moreels, Tom, Monino, Laurent, Dahlqvist, Caroline, Delire, B., Coubeau, Laurent, Ciccarelli, Olga, Bonaccorsi Riani, E., Goffette, Pierre, Sokal, Etienne, Piessevaux, P, and Belgian Week of Gastroenterology: the digital experience in 2021

Abstract

T. MOREELS (1), L. MONINO (1), G. DAHLQVIST (1), B. DELIRE (1), L. COUBEAU (2), O. CICCARELLI (2), E. BONACCORSI RIANI (2), P. GOFFETTE (3), E. SOKAL (4), H. PIESSEVAUX (1) / [1] Cliniques universitaires Saint-Luc, Brussels, Belgium, Hépato-Gastroentérologie, [2] Cliniques universitaires Saint-Luc, Brussels, Belgium, Transplantation abdominale, [3] Cliniques universitaires Saint-Luc, Brussels, Belgium, Radiologie, [4] Cliniques universitaires Saint-Luc, Brussels, Belgium, Gastroentérologie & Hépatologie Pédiatrique Introduction Biliary complications after liver transplantation are frequently dealt with by means of endoscopic retrograde cholangiopancreatograpy (ERCP) using a duodenoscope. However, when the bile duct is anastomosed on a Roux-en-Y jejunal limb, the biliary system is out of reach for conventional ERCP, and it is accessed usually via percutaneous transhepatic cholangiography (PTC) or surgery. Aim We retrospectively studied the feasibility of single-balloon enteroscopy-assisted ERCP (SBE-ERCP) to evaluate and treat biliary complications in liver transplant patients with Roux-en-Y reconstruction. Methods Between 2016 and 2020 all SBE-ERCP procedures in liver transplant patients were analysed for indications, technical and clinical success and adverse events. Results A total of 40 patients (26 males) with a mean age of 43±3 years (range 13-81) underwent 69 SBE-ERCP procedures. Indications were suspicion of anastomotic stricture (40%), cholangitis (32.5%), bile duct stones (20%), biliary leak (2.5%), haemobilia (2.5%) and sepsis of unknown origin (2.5%). Technical success rate per patient was 85% (34/40). Failure was due to inability to reach the hepaticojejunal anastomosis. SBE-ERCP was normal in 12/34 (35%), confirmed the anastomotic stricture in 12/34 (35%), bile duct stones in 6/34 (18%), indwelling metallic stent in 2/34 (6%) and biliary leak and bile duct torsion both in 1/34 (3%). Biliary endoscopic interventions: balloon dilatation (6-9 mm), plastic

Published
2021

33. Suspected Bile Duct Pathology in ROUX-EN-Y Liver Transplant Patients: Lessons Learned From Single-Balloon Enteroscopy-Assisted ERCP

Author

UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Moreels, Tom, Monino, Laurent, Dahlqvist, Géraldine, Delire, Bénédicte, Coubeau, Laurent, Ciccarelli, Olga, Bonaccorsi Riani, Eliano, Goffette, Pierre, Sokal, Etienne, Piessevaux, Hubert, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Moreels, Tom, Monino, Laurent, Dahlqvist, Géraldine, Delire, Bénédicte, Coubeau, Laurent, Ciccarelli, Olga, Bonaccorsi Riani, Eliano, Goffette, Pierre, Sokal, Etienne, and Piessevaux, Hubert

Published
2021

34. The real incidence of biliary tract complications after adult liver transplantation: the role of the prospective routine use of cholangiography during post-transplant follow-up

Author

Navez, Julie, Iesari, Samuele, Kourta, Dhoha, Baami-Mariza, Kente, Nadiri, Marwan, Goffette, Pierre, Baldin, Paméla, Ackenine, Kevin, Bonaccorsi-Riani, Eliano, Ciccarelli, Olga, Coubeau, Laurent, Moreels, Tom, Lerut, Jan Paul, Navez, Julie, Iesari, Samuele, Kourta, Dhoha, Baami-Mariza, Kente, Nadiri, Marwan, Goffette, Pierre, Baldin, Paméla, Ackenine, Kevin, Bonaccorsi-Riani, Eliano, Ciccarelli, Olga, Coubeau, Laurent, Moreels, Tom, and Lerut, Jan Paul

Abstract

Biliary tract complications (BTCs) still burden liver transplantation (LT). The wide reporting variability highlights the absence of systematic screening. From 2000 to 2009, simultaneous liver biopsy and direct biliary visualization were prospectively performed in 242 recipients at 3 and 6 months (n = 212, 87.6%) or earlier when indicated (n = 30, 12.4%). Median follow-up was 148 (107–182) months. Seven patients (2.9%) experienced postprocedural morbidity. BTCs were initially diagnosed in 76 (31.4%) patients; 32 (42.1%) had neither clinical nor biological abnormalities. Acute cellular rejection (ACR) was present in 27 (11.2%) patients and in 6 (22.2%) BTC patients. Nine (3.7%) patients with normal initial cholangiography developed BTCs after 60 (30–135) months post-LT. BTCs directly lead to 7 (2.9%) re-transplantations and 14 (5.8%) deaths resulting in 18 (7.4%) allograft losses. Bile duct proliferation at 12-month biopsy proved an independent risk factor for graft loss (P = 0.005). Systematic biliary tract and allograft evaluation allows the incidence and extent of biliary lesions to be documented more precisely and to avoid erroneous treatment of ACR. The combination ‘abnormal biliary tract-canalicular proliferation’ is an indicator of worse graft outcome. BTCs are responsible for important delayed allograft and patient losses. These results underline the importance of life-long follow-up and appropriate timing for re-transplantation., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

43. The real incidence of biliary tract complications after adult liver transplantation: the role of the prospective routine use of cholangiography during post‐transplant follow‐up

Author

Navez, Julie, primary, Iesari, Samuele, additional, Kourta, Dhoha, additional, Baami‐Mariza, Kente, additional, Nadiri, Marwan, additional, Goffette, Pierre, additional, Baldin, Pamela, additional, Ackenine, Kevin, additional, Bonaccorsi‐Riani, Eliano, additional, Ciccarelli, Olga, additional, Coubeau, Laurent, additional, Moreels, Tom, additional, and Lerut, Jan, additional

Published
2020
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46. TACROLIMUS (TAC) MONOTHERAPY IN LIVER TRANSPLANTATION (LT): ONE-YEAR RESULTS OF A PROSPECTIVE, RANDOMIZED, DOUBLE-BLINDED PLACEBO-CONTROLLED STUDY: O-313

Author

Lerut, Jan, Ciccarelli, Olga, Bonaccorsi-Riani, Eliano, Mathis, Jules, Verbaandert, Catherine, Talpe, Stéphanie, Lemaire, Julien, Vanthuyne, Vincent, Roggen, Francine, De Reyck, Chantal, Goffette, Pierre, Latinne, Dominique, Orlando, Giuseppe, Rahier, Jacques, Sempoux, Christine, Wallemacq, Pierre, and Giancarlo, Pierre

Published
2009

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