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Tigist Kefyalew Goffe,1,* Zewdie Aderaw Alemu,1,* Tadios Niguss Derese,2,* Yohannes Bayou Tilahun,3 Robel Bayou Tilahun4 1Department of Public Health, Gamby Medical and Business College, Addis Ababa, Ethiopia; 2Department of Research and Training, Eka Kotebe General Hospital, Addis Ababa, Ethiopia; 3General Practitioner at Health Hub Specialty Clinics by Al-Futtaim, Dubai, United Arab Emirates; 4General Practitioner, Uniteam Medical Assistant, Abu Dhabi, United Arab Emirates*These authors contributed equally to this workCorrespondence: Tigist Kefyalew Goffe, Tel +251960291564, Email tgkefyalew59@gmail.comBackground: Although diffuse alveolar damage and respiratory failure are the most common symptoms of coronavirus disease 2019, other organ involvement, such as the kidney, has been reported. The incidence of acute kidney injury in COVID-19 patients has been reported to vary greatly. In this study, we look at the magnitude and risk factors for acute kidney injury in COVID-19 patients in Ethiopia, a developing country.Methods: A hospital-based retrospective cross-sectional study design was conducted among admitted COVID-19 patients at Eka Kotebe general hospital and Saint Peter COVID-19 treatment center by reviewing data from September 2020 to September 2021. A random sampling technique with proportional size allocation was used to select a total sample of 402 patients (225 from Eka Kotebe and 177 from St. Peter). Secondary data was collected from patient medical records using a standard, pre-tested data collection checklist using the Kobo toolbox, which was then exported to SPSS version 25.0 for analysis. The association between dependent and independent variables was analyzed using binary logistic regression. A statistical significance test was declared at a p value of