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1. Analysis of Testbeam Data of the Highly Granular RPC-Steel CALICE Digital Hadron Calorimeter and Validation of Geant4 Monte Carlo Models

Author

CALICE Collaboration, Chefdeville, M., Repond, J., Schlereth, J., Smith, J. R., Trojand, D., Xia, L., Zhang, Q., Apostolakis, J., Grefe, C., Ivantchenko, V., Folger, G., Ribon, A., Uzhinskiy, V., Blazey, G. C., Dyshkant, A., Francis, K., Zutshi, V., Bach, O., Bocharnikov, V., Brianne, E., Gadow, K., Göttlicher, P., Hartbrich, O., Heuchel, D., Krivan, F., Krüger, K., Kvasnicka, J., Lu, S., Neubüser, C., Pinto, O., Provenza, A., Reinecke, M., Sefkow, F., Schuwalow, S., Sudo, Y., Tran, H. L., Buhmann, P., Garutti, E., Lomidze, D., Martens, S., Matysek, M., Bilki, B., Northacker, D., Onel, Y., van Doren, B., Wilson, G. W., Kawagoe, K., Miura, Y., Mori, R., Sekiya, I., Suehara, T., Yoshioka, T., Belver, D., Alamillo, E. Calvo, Fouz, M. C., Cabrera, H. García, Marín, J., Navarrete, J., Pelayo, J. Puerta, Verdugo, A., Corriveau, F., Freund, B., Chadeeva, M., Danilov, M., Gabriel, M., Emberger, L., Graf, C., Israeli, Y., Simon, F., Szalay, M., Windel, H., Bilokin, S., Bonis, J., Irles, A., Pöschl, R., Thiebault, A., Richard, F., Zerwas, D., Cvach, J., Janata, M., Kovalcuk, M., Polak, I., Smolik, J., Vrba, V., Zalesak, J., Zuklin, J., Takeshita, T., Elkhalii, A., Götze, M., Zeitnitz, C., Chang, S., Khan, A., Kim, D. H., Kong, D. J., and Oh, Y. D.

Subjects
Physics - Instrumentation and Detectors
Abstract

We present a study of the response of the highly granular Digital Hadronic Calorimeter with steel absorbers, the Fe-DHCAL, to positrons, muons, and pions with momenta ranging from 2 to 60 GeV/c. Developed in the context of the CALICE collaboration, this hadron calorimeter utilises Resistive Plate Chambers as active media, interspersed with steel absorber plates. With a transverse granularity of $1\,\times\,1\,$cm$^{2}$ and a longitudinal segmentation of 38 layers, the calorimeter counted 350,208 readout channels, each read out with single-bit resolution (digital readout). The data were recorded in the Fermilab test beam in 2010-11. The analysis includes measurements of the calorimeter response and the energy resolution to positrons and muons, as well as detailed studies of various shower shape quantities. The results are compared to simulations based on Geant4, which utilise different electromagnetic and hadronic physics lists.

Published
2019
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2. Hadronic Energy Resolution of a Combined High Granularity Scintillator Calorimeter System

Author

CALICE Collaboration, Repond, J., Xia, L., Apostolakis, J., Folger, G., Ivantchenko, V., Ribon, A., Uzhinskiy, V., Boumediene, D., Francais, V., Blazey, G. C., Dyshkant, A., Francis, K., Zutshi, V., Bach, O., Brianne, E., Ebrahimi, A., Gadow, K., Gttlicher, P., Krivan, O. Hartbrich F., Krüger, K., Kvasnicka, J., Lu, S., Neubüser, C., Provenza, A., Reinecke, M., Sefkow, F., Schuwalow, S., Sudo, Y., Tran, H. L., Buhmann, P., Garutti, E., Laurien, S., Lomidze, D., Matysek, M., Kaplan, A., Schultz-Coulon, H. -Ch., Wilson, G. W., Jeans, D., Kawagoe, K., Sekiya, I., Suehara, T., Yamashiro, H., Yoshioka, T., Wing, M., Kotera, K., Nishiyama, M., Sakuma, T., Takeshita, T., Tozuka, S., Tubokawa, T., Uozumi, S., Alamillo, E. Calvo, Fouz, M. C., Marin, J., Navarrete, J., Pelayo, J. Puerta, Verdugo, A., Chadeeva, M., Danilov, M., Drutskoy, A., Popova, E., Rusinov, V., Tarkovsky, E., Emberger, L., Gabriel, M., Graf, C., Israeli, Y., van der Kolk, N., Simon, F., Szalay, M., Windel, H., Bonis, S. Bilokin J., Pöschl, R., Irles, A., Thiebault, A., Richard, F., Zerwas, D., Anduze, M., Balagura, V., Becheva, E., Boudry, V., Brient, J-C., Cornat, R., Edy, E., Gastaldi, M. Frotin F., Li, B., Magniette, F., Nanni, J., Rubio-Roy, M., Shpak, K., Tran, T. H., Videau, H., Cvach, J., Janata, M., Kovalcuk, M., Polak, I., Smolik, J., Vrba, V., Zalesak, J., Zuklin, J., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Elkhalii, A., Götze, M., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

This paper presents results obtained with the combined CALICE Scintillator Electromagnetic Calorimeter, Analogue Hadronic Calorimeter and Tail Catcher & Muon Tracker, three high granularity scintillator-SiPM calorimeter prototypes. The response of the system to pions with momenta between 4 GeV/c and 32 GeV/c is analysed, including the energy response, resolution, and longitudinal shower profiles. The results of a software compensation technique based on weighting according to hit energy are compared to those of a standard linear energy reconstruction. The results are compared to predictions of the GEANT4 physics lists QGSP_BERT_HP and FTFP_BERT_HP., Comment: 31 pages, 41 figures

Published
2018

3. Construction and Response of a Highly Granular Scintillator-based Electromagnetic Calorimeter

Author

CALICE collaboration, Repond, J., Xia, L., Eigen, G., Price, T., Watson, N. K., Winter, A., Thomson, M. A., Blazey, G. C., Dyshkant, A., Francis, K., Zutshi, V., Gadow, K., Göttlicher, P., Hartbrich, O., Krivan, F., Krüger, K., Lu, S., Lutz, B., Reinecke, M., Sefkow, F., Sudo, Y., Tran, H. L., Kaplan, A., Schultz-Coulon, H. -Ch., Bilki, B., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Sekiya, I., Suehara, T., Yamashiro, H., Yoshioka, T., Gabriel, M., Goecke, P., Graf, C., Israeli, Y., van der Kolk, N., Simon, F., Szalay, M., Winde, H., Bilokin, l S., Bonis, J., Pöschl, R., Thiebault, A., Richard, F., Zerwas, D., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Cvach, J., Janata, M., Kovalcuk, M., Kvasnicka, J., Polak, I., Smolik, J., Vrba, V., Zalesak, J., Zuklin, J., Choi, W., Kotera, K., Nishiyama, M., Sakuma, T., Takeshita, T., Tozuka, S., Tsubokawa, T., Uozumi, S., Jeans, D., Ootani, W., Liu, L., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Ikuno, T., Takahashi, Y., and Götze, M.

Subjects
Physics - Instrumentation and Detectors
Abstract

A highly granular electromagnetic calorimeter with scintillator strip readout is being developed for future lepton collider experiments. A prototype of 21.5 $X_0$ depth and $180 \times 180 $mm$^2$ transverse dimensions was constructed, consisting of 2160 individually read out $10 \times 45 \times 3$ mm$^3$ scintillator strips. This prototype was tested using electrons of 2--32 GeV at the Fermilab Test Beam Facility in 2009. Deviations from linear energy response were less than 1.1\%, and the intrinsic energy resolution was determined to be $(12.5 \pm 0.1 (\mathrm{stat.}) \pm0.4 (\mathrm{syst.}))\%/\sqrt{E[\mathrm{GeV}]}\oplus (1.2 \pm 0.1(\mathrm{stat.})^{+0.6}_{-0.7}(\mathrm{syst.}))\%$, where the uncertainties correspond to statistical and systematic sources, respectively., Comment: This article is published in Nuclear Inst. and Methods in Physics Research, A 887 (2018) 150-168

Published
2017

5. Shower development of particles with momenta from 15 GeV to 150 GeV in the CALICE scintillator-tungsten hadronic calorimeter

Author

The CALICE collaboration, Chefdeville, M., Karyotakis, Y., Repond, J., Schlereth, J., Xia, L., Eigen, G., Marshall, J. S., Thomson, M. A., Ward, D. R., Tehrani, N. Alipour, Apostolakis, J., Dannheim, D., Elsener, K., Folger, G., Grefe, C., Ivantchenko, V., Killenberg, M., Klempt, W., van der Kraaij, E., Linssen, L., Lucaci-Timoce, A. -I., Münnich, A., Poss, S., Ribon, A., Roloff, P., Sailer, A., Schlatter, D., Sicking, E., Strube, J., Uzhinskiy, V., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Blazey, G. C., Dyshkant, A., Francis, K., Zutshi, V., Giraud, J., Grondin, D., Hostachy, J. -Y., Brianne, E., Cornett, U., David, D., Falley, G., Gadow, K., Göttlicher, P., Günter, C., Hartbrich, O., Hermberg, B., Irles, A., Karstensen, S., Krivan, F., Krüger, K., Kvasnicka, J., Lu, S., Lutz, B., Morozov, S., Morgunov, V., Neubüser, C., Provenza, A., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Tran, H. L., Vargas-Trevino, A., Garutti, E., Laurien, S., Matysek, M., Ramilli, M., Schröder, S., Briggl, K., Eckert, P., Harion, T., Munwes, Y., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Onel, Y., Kawagoe, K., Hirai, H., Sudo, Y., Suehara, T., Sumida, H., Takada, S., Tomita, T., Yoshioka, T., Wing, M., Alamillo, E. Calvo, Fouz, M. -C., Marin, J., Puerta-Pelayo, J., Verdugo, A., Bobchenko, B., Chadeeva, M., Danilov, M., Markin, O., Mizuk, R., Novikov, E., Rusinov, V., Tarkovsky, E., Kirikova, N., Kozlov, V., Soloviev, Y., Besson, D., Buzhan, P., Popova, E., Gabriel, M., Kiesling, C., van der Kolk, N., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Cornebise, P., Richard, F., Pöschl, R., Rouëné, J., Thiebault, A., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cizel, J-B., Cornat, R., Frotin, M., Gastaldi, F., Haddad, Y., Magniette, F., Nanni, J., Pavy, S., Rubio-Roy, M., Shpak, K., Tran, T. H., Videau, H., Yu, D., Callier, S., di Lorenzo, S. Conforti, Dulucq, F., Fleury, J., Martin-Chassard, G., de la Taille, Ch., Raux, L., Seguin-Moreau, N., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kovalcuk, M., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Ieki, S., Kamiya, Y., Ootani, W., Shibata, N., Chen, S., Jeans, D., Komamiya, S., Kozakai, C., Nakanishi, H., Götze, M., Sauer, J., Weber, S., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We present a study of showers initiated by electrons, pions, kaons, and protons with momenta from 15 GeV to 150 GeV in the highly granular CALICE scintillator-tungsten analogue hadronic calorimeter. The data were recorded at the CERN Super Proton Synchrotron in 2011. The analysis includes measurements of the calorimeter response to each particle type as well as measurements of the energy resolution and studies of the longitudinal and radial shower development for selected particles. The results are compared to Geant4 simulations (version 9.6.p02). In the study of the energy resolution we include previously published data with beam momenta from 1 GeV to 10 GeV recorded at the CERN Proton Synchrotron in 2010., Comment: 35 pages, 21 figures, 8 tables

Published
2015
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6. Testing Hadronic Interaction Models using a Highly Granular Silicon-Tungsten Calorimeter

Author

The CALICE Collaboration, Bilki, B., Repond, J., Schlereth, J., Xia, L., Deng, Z., Li, Y., Wang, Y., Yue, Q., Yang, Z., Eigen, G., Mikami, Y., Price, T., Watson, N. K., Thomson, M. A., Ward, D. R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Cârloganu, C., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Blazey, G. C., Dyshkant, A., Francis, K., Lima, J. G. R., Salcido, P., Zutshi, V., Boisvert, V., Green, B., Misiejuk, A., Salvatore, F., Kawagoe, K., Miyazaki, Y., Sudo, Y., Suehara, T., Tomita, T., Ueno, H., Yoshioka, T., Apostolakis, J., Folger, G., Ivantchenko, V., Ribon, A., Uzhinskiy, V., Cauwenbergh, S., Tytgat, M., Zaganidis, N., Hostachy, J. -Y., Morin, L., Gadow, K., Göttlicher, P., Günter, C., Krüger, K., Lutz, B., Reinecke, M., Sefkow, F., Feege, N., Garutti, E., Laurien, S., Lu, S., Marchesini, I., Matysek, M., Ramilli, M., Kaplan, A., Norbeck, E., Northacker, D., Onel, Y., Kim, E. J., van Doren, B., Wilson, G. W., Wing, M., Bobchenko, B., Chadeeva, M., Chistov, R., Danilov, M., Drutskoy, A., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Besson, D., Popova, E., Gabriel, M., Kiesling, C., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Faucci-Giannelli, M., Fleury, J., Frisson, T., Kégl, B., van der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Pöschl, R., Raux, L., Rouëné, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Becheva, E., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Magniette, F., Matthieu, A., de Freitas, P. Mora, Videau, H., Augustin, J-E., David, J., Ghislain, P., Lacour, D., Lavergne, L., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Jeans, D., and Götze, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A detailed study of hadronic interactions is presented using data recorded with the highly granular CALICE silicon-tungsten electromagnetic calorimeter. Approximately 350,000 selected negatively charged pion events at energies between 2 and 10 GeV have been studied. The predictions of several physics models available within the Geant4 simulation tool kit are compared to this data. A reasonable overall description of the data is observed; the Monte Carlo predictions are within 20% of the data, and for many observables much closer. The largest quantitative discrepancies are found in the longitudinal and transverse distributions of reconstructed energy., Comment: 28 pages, 24 figures, accepted for publication in NIM A

Published
2014
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7. The Time Structure of Hadronic Showers in highly granular Calorimeters with Tungsten and Steel Absorbers

Author

Adloff, C., Blaising, J. -J., Chefdeville, M., Drancourt, C., Gaglione, R., Geffroy, N., Karyotakis, Y., Koletsou, I., Prast, J., Repond, G. Vouters J., Schlereth, J., Baldolemar, L. Xia E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Eigen, G., Thomson, M. A., Ward, D. R., Benchekroun, D., Hoummada, A., Apostolakis, Y. Khoulaki J., Arfaoui, S., Benoit, M., Dannheim, D., Elsener, K., Folger, G., Grefe, C., Ivantchenko, V., Killenberg, M., Klempt, W., van der Kraaij, E., Linssen, L., Lucaci-Timoce, A. -I., Münnich, A., Poss, S., Ribon, A., Roloff, P., Sailer, A., Schlatter, D., Sicking, E., Strube, J., Uzhinskiy, V., Carloganu, C., Gay, P., Manen, S., Royer, L., Cornett, U., David, D., Ebrahimi, A., Falley, G., Feege, N., Gadow, K., Göttlicher, P., Günter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krüger, K., Lu, S., Lutz, B., Morozov, S., Morgunov, V., Neubüser, C., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Fagot, A., Tytgat, M., Zaganidis, N., Hostachy, J. -Y., Morin, L., Garutti, E., Laurien, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Miyazaki, Y., Sudo, Y., Ueno, H., Yoshioka, T., Dauncey, P. D., Gil, E. Cortina, Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Ete, R., Grenier, G., Han, R., Ianigro, J-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Donckt, M. Vander, Antequera, Y. Zoccarato J. Berenguer, Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Rusinov, V., Tarkovsky, E., Kozlov, V., Soloviev, Y., Besson, D., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Popova, E., Tikhomirov, V., Gabriel, M., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., di Lorenzo, S. Conforti, Cornebise, P., Fleury, J., Frisson, T., van der Kolk, N., Richard, F., Pöschl, R., Rouene, J., Anduze, M., Balagura, V., Becheva, E., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Ruan, M., Tran, T. H., Videau, H., Callier, S., Dulucq, F., Martin-Chassard, G., de la Taille, Ch., Raux, L., Seguin-Moreau, N., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, ., Ghazlane, H., Kotera, K., Ono, H., Takeshita, T., Uozumi, S., Chai, J. S., Song, H. S., Lee, S. H., Götze, M., Sauer, J., Weber, S., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The intrinsic time structure of hadronic showers influences the timing capability and the required integration time of hadronic calorimeters in particle physics experiments, and depends on the active medium and on the absorber of the calorimeter. With the CALICE T3B experiment, a setup of 15 small plastic scintillator tiles read out with Silicon Photomultipliers, the time structure of showers is measured on a statistical basis with high spatial and temporal resolution in sampling calorimeters with tungsten and steel absorbers. The results are compared to GEANT4 (version 9.4 patch 03) simulations with different hadronic physics models. These comparisons demonstrate the importance of using high precision treatment of low-energy neutrons for tungsten absorbers, while an overall good agreement between data and simulations for all considered models is observed for steel., Comment: 24 pages including author list, 9 figures, published in JINST

Published
2014
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8. Performance of the first prototype of the CALICE scintillator strip electromagnetic calorimeter

Author

CALICE Collaboration, Francis, K., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Eigen, G., Mikami, Y., Watson, N. K., Thomson, M. A., Ward, D. R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dotti, A., Folger, G., Ivantchenko, V., Ribon, A., Uzhinskiy, V., Carloganu, C., Gay, P., Manen, S., Royer, L., Tytgat, M., Zaganidis, N., Blazey, G. C., Dyshkant, A., Lima, J. G. R., Zutshi, V., Hostachy, J. -Y., Morin, L., Cornett, U., David, D., Ebrahimi, A., Falley, G., Gadow, K., Goettlicher, P., Guenter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krueger, K., Lutz, B., Morozov, S., Morgunov, V., Neubueser, C., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Garutti, E., Laurien, S., Lu, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Sudo, Y., Yoshioka, T., Dauncey, P. D., Wing, M., Salvatore, F., Gil, E. Cortina, Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Grenier, G., Han, R., Ianigro, J-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Donckt, M. Vander, Zoccarato, Y., Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Besson, D., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., van der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Poeschl, R., Raux, L., Rouene, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Musat, G., Ruan, M., Tran, T. H., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Kotera, K., Ono, H., Takeshita, T., Uozumi, S., Jeans, D., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Goetze, M., Sauer, J., Weber, S., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A first prototype of a scintillator strip-based electromagnetic calorimeter was built, consisting of 26 layers of tungsten absorber plates interleaved with planes of 45x10x3 mm3 plastic scintillator strips. Data were collected using a positron test beam at DESY with momenta between 1 and 6 GeV/c. The prototype's performance is presented in terms of the linearity and resolution of the energy measurement. These results represent an important milestone in the development of highly granular calorimeters using scintillator strip technology. This technology is being developed for a future linear collider experiment, aiming at the precise measurement of jet energies using particle flow techniques.

Published
2013
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9. Shower development of particles with momenta from 1 to 10 GeV in the CALICE Scintillator-Tungsten HCAL

Author

Adloff, C., Blaising, J. -J., Chefdeville, M., Drancourt, C., Gaglione, R., Geffroy, N., Karyotakis, Y., Koletsou, I., Prast, J., Vouters, G., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Eigen, G., Thomson, M. A., Ward, D. R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dannheim, D., Dotti, A., Elsener, K., Folger, G., Grefe, C., Ivantchenko, V., Killenberg, M., Klempt, W., van der Kraaij, E., Lam, C. B., Linssen, L., Lucaci-Timoce, A. -I., Muennich, A., Poss, S., Ribon, A., Sailer, A., Schlatter, D., Strube, J., Uzhinskiy, V., Carloganu, C., Gay, P., Manen, S., Royer, L., Tytgat, M., Zaganidis, N., Blazey, G. C., Dyshkant, A., Lima, J. G. R., Zutshi, V., Hostachy, J. -Y., Morin, L., Cornett, U., David, D., Ebrahimi, A., Falley, G., Feege, N., Gadow, K., Goettlicher, P., Guenter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krueger, K., Lu, S., Lutz, B., Morozov, S., Morgunov, V., Neubueser, C., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Garutti, E., Laurien, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Sudo, Y., Yoshioka, T., Dauncey, P. D., Wing, M., Salvatore, F., Gil, E. Cortina, Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Grenier, G., Han, R., Ianigro, J-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Donckt, M. Vander, Zoccarato, Y., Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Kirikova, N., Kozlov, V., Soloviev, Y., Besson, D., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., van der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Poeschl, R., Raux, L., Rouene, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Musat, G., Ruan, M., Tran, T. H., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Kotera, K., Takeshita, T., Uozumi, S., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Goetze, M., Sauer, J., Weber, S., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

Lepton colliders are considered as options to complement and to extend the physics programme at the Large Hadron Collider. The Compact Linear Collider (CLIC) is an $e^+e^-$ collider under development aiming at centre-of-mass energies of up to 3 TeV. For experiments at CLIC, a hadron sampling calorimeter with tungsten absorber is proposed. Such a calorimeter provides sufficient depth to contain high-energy showers, while allowing a compact size for the surrounding solenoid. A fine-grained calorimeter prototype with tungsten absorber plates and scintillator tiles read out by silicon photomultipliers was built and exposed to particle beams at CERN. Results obtained with electrons, pions and protons of momenta up to 10 GeV are presented in terms of energy resolution and shower shape studies. The results are compared with several GEANT4 simulation models in order to assess the reliability of the Monte Carlo predictions relevant for a future experiment at CLIC., Comment: 28 pages, 23 figures, 3 tables

Published
2013
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10. Validation of GEANT4 Monte Carlo Models with a Highly Granular Scintillator-Steel Hadron Calorimeter

Author

Adloff, C., Blaha, J., Blaising, J. -J., Drancourt, C., Espargilière, A., Gaglione, R., Geffroy, N., Karyotakis, Y., Prast, J., Vouters, G., Francis, K., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Buanes, T., Eigen, G., Mikami, Y., Watson, N. K., Mavromanolakis, G., Thomson, M. A., Ward, D. R., Yan, W., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dotti, A., Folger, G., Ivantchenko, V., Uzhinskiy, V., Benyamna, M., Cârloganu, C., Fehr, F., Gay, P., Manen, S., Royer, L., Blazey, G. C., Dyshkant, A., Lima, J. G. R., Zutshi, V., Hostachy, J. -Y., Morin, L., Cornett, U., David, D., Falley, G., Gadow, K., Göttlicher, P., Günter, C., Hermberg, B., Karstensen, S., Krivan, F., Lucaci-Timoce, A. -I., Lu, S., Lutz, B., Morozov, S., Morgunov, V., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Vargas-Trevino, A., Feege, N., Garutti, E., Marchesinik, I., Ramilli, M., Eckert, P., Harion, T., Kaplan, A., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Onel, Y., Wilson, G. W., Kawagoe, K., Dauncey, P. D., Magnan, A. -M., Bartsch, V., Wing, M., Salvatore, F., Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Kirikova, N., Kozlov, V., Soloviev, Y., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., van der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Pöschl, R., Raux, L., Rouëné, J., Seguin-Moreau, N., Anduze, M., Boudry, V., Brient, J-C., Jeans, D., de Freitas, P. Mora, Musat, G., Reinhard, M., Ruan, M., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Takeshita, T., Uozumi, S., Götze, M., Hartbrich, O., Sauer, J., Weber, S., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Calorimeters with a high granularity are a fundamental requirement of the Particle Flow paradigm. This paper focuses on the prototype of a hadron calorimeter with analog readout, consisting of thirty-eight scintillator layers alternating with steel absorber planes. The scintillator plates are finely segmented into tiles individually read out via Silicon Photomultipliers. The presented results are based on data collected with pion beams in the energy range from 8GeV to 100GeV. The fine segmentation of the sensitive layers and the high sampling frequency allow for an excellent reconstruction of the spatial development of hadronic showers. A comparison between data and Monte Carlo simulations is presented, concerning both the longitudinal and lateral development of hadronic showers and the global response of the calorimeter. The performance of several GEANT4 physics lists with respect to these observables is evaluated.

Published
2013
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11. Track segments in hadronic showers in a highly granular scintillator-steel hadron calorimeter

Author

CALICE Collaboration, Adloff, C., Blaising, J. -J., Chefdeville, M., Drancourt, C., Gaglione, R., Geffroy, N., Karyotakis, Y., Koletsou, I., Prast, J., Vouters, G., Francis, K., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Eigen, G., Mikami, Y., Watson, N. K., Mavromanolakis, G., Thomson, M. A., Ward, D. R., Yan, W., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dannheim, D., Dotti, A., Folger, G., Ivantchenko, V., Klempt, W., van der Kraaij, E., Lucaci-Timoce, A. -I., Ribon, A., Schlatter, D., Uzhinskiy, V., Carloganu, C., Gay, P., Manen, S., Royer, L., Tytgat, M., Zaganidis, N., Blazey, G. C., Dyshkant, A., Lima, J. G. R., Zutshi, V., Hostachy, J. -Y., Morin, L., Cornett, U., David, D., Falley, G., Gadow, K., Göttlicher, P., Günter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krüger, K., Lu, S., Morozov, S., Morgunov, V., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Feege, N., Garutti, E., Laurien, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Onel, Y., Wilson, G. W., Kawagoe, K., Sudo, Y., Yoshioka, T., Dauncey, P. D., Magnan, A. -M., Bartsch, V., Wing, M., Salvatore, F., Gil, E. Cortina, Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Grenier, G., Han, R., Ianigro, J-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Donckt, M. Vander, Zoccarato, Y., Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Kirikova, N., Kozlov, V., Soloviev, Y., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., van der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Pöschl, R., Raux, L., Rouene, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Musat, G., Ruan, M., Tran, T. H., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Kotera, K., Takeshita, T., Uozumi, S., Jeans, D., Götze, M., Sauer, J., Weber, S., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We investigate the three dimensional substructure of hadronic showers in the CALICE scintillator-steel hadronic calorimeter. The high granularity of the detector is used to find track segments of minimum ionising particles within hadronic showers, providing sensitivity to the spatial structure and the details of secondary particle production in hadronic cascades. The multiplicity, length and angular distribution of identified track segments are compared to GEANT4 simulations with several different shower models. Track segments also provide the possibility for in-situ calibration of highly granular calorimeters., Comment: 27 pages, 17 figures, accepted for publication in JINST

Published
2013

12. Construction and response of a highly granular scintillator-based electromagnetic calorimeter

Author

Repond, J., Xia, L., Eigen, G., Price, T., Watson, N.K., Winter, A., Thomson, M.A., Cârloganu, C., Blazey, G.C., Dyshkant, A., Francis, K., Zutshi, V., Gadow, K., Göttlicher, P., Hartbrich, O., Kotera, K., Krivan, F., Krüger, K., Lu, S., Lutz, B., Reinecke, M., Sefkow, F., Sudo, Y., Tran, H.L., Kaplan, A., Schultz-Coulon, H.-Ch., Bilki, B., Northacker, D., Onel, Y., Wilson, G.W., Kawagoe, K., Sekiya, I., Suehara, T., Yamashiro, H., Yoshioka, T., Alamillo, E. Calvo, Fouz, M.C., Marin, J., Navarrete, J., Pelayo, J. Puerta, Verdugo, A., Chadeeva, M., Danilov, M., Gabriel, M., Goecke, P., Graf, C., Israeli, Y., Kolk, N. van der, Simon, F., Szalay, M., Windel, H., Bilokin, S., Bonis, J., Pöschl, R., Thiebault, A., Richard, F., Zerwas, D., Balagura, V., Boudry, V., Brient, J.-C., Cornat, R., Cvach, J., Janata, M., Kovalcuk, M., Kvasnicka, J., Polak, I., Smolik, J., Vrba, V., Zalesak, J., Zuklin, J., Choi, W., Nishiyama, M., Sakuma, T., Takeshita, T., Tozuka, S., Tsubokawa, T., Uozumi, S., Jeans, D., Ootani, W., Liu, L., Chang, S., Khan, A., Kim, D.H., Kong, D.J., Oh, Y.D., Ikuno, T., Takahashi, Y., and Götze, M.

Published
2018
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13. Testing hadronic interaction models using a highly granular silicon–tungsten calorimeter

Author

Bilki, B., Repond, J., Schlereth, J., Xia, L., Deng, Z., Li, Y., Wang, Y., Yue, Q., Yang, Z., Eigen, G., Mikami, Y., Price, T., Watson, N.K., Thomson, M.A., Ward, D.R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Cârloganu, C., Chang, S., Khan, A., Kim, D.H., Kong, D.J., Oh, Y.D., Blazey, G.C., Dyshkant, A., Francis, K., Lima, J.G.R., Salcido, P., Zutshi, V., Boisvert, V., Green, B., Misiejuk, A., Salvatore, F., Kawagoe, K., Miyazaki, Y., Sudo, Y., Suehara, T., Tomita, T., Ueno, H., Yoshioka, T., Apostolakis, J., Folger, G., Ivantchenko, V., Ribon, A., Uzhinskiy, V., Cauwenbergh, S., Tytgat, M., Zaganidis, N., Hostachy, J.-Y., Morin, L., Gadow, K., Göttlicher, P., Günter, C., Krüger, K., Lutz, B., Reinecke, M., Sefkow, F., Feege, N., Garutti, E., Laurien, S., Lu, S., Marchesini, I., Matysek, M., Ramilli, M., Kaplan, A., Norbeck, E., Northacker, D., Onel, Y., Kim, E.J., van Doren, B., Wilson, G.W., Wing, M., Bobchenko, B., Chadeeva, M., Chistov, R., Danilov, M., Drutskoy, A., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Besson, D., Popova, E., Gabriel, M., Kiesling, C., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M.S., Bonis, J., Callier, S., Conforti di Lorenzo, S., Cornebise, P., Doublet, Ph., Dulucq, F., Faucci-Giannelli, M., Fleury, J., Frisson, T., Kégl, B., van der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Pöschl, R., Raux, L., Rouëné, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Becheva, E., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Magniette, F., Matthieu, A., Mora de Freitas, P., Videau, H., Augustin, J-E., David, J., Ghislain, P., Lacour, D., Lavergne, L., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Jeans, D., and Götze, M.

Published
2015
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17. Performance of the first prototype of the CALICE scintillator strip electromagnetic calorimeter

Author

Francis, K., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S.T., Sosebee, M., White, A.P., Yu, J., Eigen, G., Mikami, Y., Watson, N.K., Thomson, M.A., Ward, D.R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dotti, A., Folger, G., Ivantchenko, V., Ribon, A., Uzhinskiy, V., Cârloganu, C., Gay, P., Manen, S., Royer, L., Tytgat, M., Zaganidis, N., Blazey, G.C., Dyshkant, A., Lima, J.G.R., Zutshi, V., Hostachy, J.-Y., Morin, L., Cornett, U., David, D., Ebrahimi, A., Falley, G., Gadow, K., Göttlicher, P., Günter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krüger, K., Lutz, B., Morozov, S., Morgunov, V., Neubüser, C., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Garutti, E., Laurien, S., Lu, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H.-Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Wilson, G.W., Kawagoe, K., Sudo, Y., Yoshioka, T., Dauncey, P.D., Wing, M., Salvatore, F., Cortina Gil, E., Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Grenier, G., Han, R., Ianigro, J.-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Vander Donckt, M., Zoccarato, Y., Calvo Alamillo, E., Fouz, M.-C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Besson, D., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Weuste, L., Amjad, M.S., Bonis, J., Callier, S., Conforti di Lorenzo, S., Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., van der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Pöschl, R., Raux, L., Rouëné, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Boudry, V., Brient, J.-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Musat, G., Ruan, M., Tran, T.H., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Kotera, K., Ono, H., Takeshita, T., Uozumi, S., Jeans, D., Chang, S., Khan, A., Kim, D.H., Kong, D.J., Oh, Y.D., Götze, M., Sauer, J., Weber, S., and Zeitnitz, C.

Published
2014
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23. Brain glucose utilization in systemic lupus erythematosus with neuropsychiatric symptoms: A controlled positron emission tomography study

Author

Otte, A., Weiner, S., Peter, H., Mueller-Brand, J., Goetze, M., Moser, E., Gutfleische, J., Hoegerle, S., Juengling, F., Nitzsche, E., Otte, A., Weiner, S., Peter, H., Mueller-Brand, J., Goetze, M., Moser, E., Gutfleische, J., Hoegerle, S., Juengling, F., and Nitzsche, E.

Abstract

In contrast to morphological imaging [such as magnetic resonance imaging (MRI) or computed tomography], functional imaging may be of advantage in the detection of brain abnormalities in cases of neuropsychiatric systemic lupus erythematosus (SLE). Therefore, we studied 13 patients (aged 40±14 years, 11 female, 2 male) with neuropsychiatric SLE who met four of the American Rheumatism Association criteria for the classification of SLE. Ten clinically and neurologically healthy volunteers served as controls (aged 40±12 years, 5 female, 5 male). Both groups were investigated using fluorine-18-labelled fluorodeoxyglucose brain positron emission tomography (PET) and cranial MRI. The normal controls and 11 of the 13 patients showed normal MRI scans. However, PET scan was abnormal in all 13 SLE patients. Significant group-to-group differences in the glucose metabolic index (GMI=region of interest uptake/global uptake at the level of the basal ganglia and thalamus) were found in the parieto-occipital region on both sides: the GMI of the parieto-occipital region on the right side was 0.922±0.045 in patients and 1.066±0.081 in controls (P<0.0001, Mann WhitneyU test), while on the left side it was 0.892±0.060 in patients and 1.034±0.051 in controls (P=0.0002). Parietooccipital hypometabolism is a conspicuous finding in mainly MRI-negative neuropsychiatric SLE. As the parieto-occipital region is located at the boundary of blood supply of all three major arteries, it could be the most vulnerable zone of the cerebrum and may be affected at an early stage of the cerebrovascular disease

Published
2018

26. A flexible services and communications gateway for smart home and monitoring applications

Author

Goetze, M., Kattanek, W., Peukert, R., Chervakova, E., Toepfer, H., Dietrich, Peter ; orcid:0000-0003-2699-2354, Bumberger, Jan, Goetze, M., Kattanek, W., Peukert, R., Chervakova, E., Toepfer, H., Dietrich, Peter ; orcid:0000-0003-2699-2354, and Bumberger, Jan

Abstract

Deployment of wireless sensor networks (WSN) has become an established means of monitoring processes and situations in a variety of application fields. Using such a technological platform for providing services to different stakeholders (such as tenants and operators) at once enables monitoring and communications to be combined cost-efficiently. The results of advanced development efforts have been deployed retrofittingexisting buildings, where the integration of wireless sensor networking technologies will open up application scenarios beyond what is commonly termed as “smart home”. Based on this experience, such platforms will be investigated in less controlled environments, such as urban or environmental applications. In this work, we introduce a dedicated service gateway. The generic overall system architecture is described briefly and particular design considerations aiming for extensibility, cost efficiency, and low power consumption are discussed. The system is designed for providing both local and centralized services. First examples ofpractical applications are described and illustrated.

Published
2013

32. DOTATOC: A powerful new tool for receptor-mediated radionuclide therapy

Author

Otte, A., Jermann, E., Behe, M., Goetze, M., Bucher, H., Roser, H., Heppeler, A., Mueller-Brand, J., Maecke, H., Otte, A., Jermann, E., Behe, M., Goetze, M., Bucher, H., Roser, H., Heppeler, A., Mueller-Brand, J., and Maecke, H.

Abstract

This study presents the first successful use of a peptidic vector, DOTATOC, labelled with the β-emitting radioisotope yttrium-90, for the treatment of a patient with somatostatin receptor-positive abdominal metastases of a neuroendocrine carcinoma of unknown localization. Tumour response and symptomatic relief were achieved. In addition, the new substance DOTA-TOC was labelled with the diagnostic chemical analogue indium-111 and studied in three patients with histopathologically verified neuroendocrine abdominal tumours for its diagnostic sensitivity and compared with the commercially available OctreoScan. In all patients the kidney-to-tumour uptake ratio (in counts per pixel) was on average 1.9-fold lower with111In-DOTATOC than with OctreoScan. DOTATOC could be a potential new diagnostic and therapeutic agent in the management of neuroendocrine tumours

33. Shower development of particles with momenta from 1 to 10 GeV in the CALICE Scintillator-Tungsten HCAL

Author

Laboratoire d'Annecy le Vieux de Physique des Particules (LAPP) ; CNRS - IN2P3 - Université de Savoie, European Organization for Nuclear Research (CERN) ; CERN, Laboratoire de Physique Corpusculaire [Clermont-Ferrand] (LPC) ; CNRS - IN2P3 - Université Blaise Pascal - Clermont-Ferrand II, Laboratoire de Physique Subatomique et de Cosmologie (LPSC) ; CNRS - IN2P3 - Université Joseph Fourier - Grenoble I - Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Institut de Physique Nucléaire de Lyon (IPNL) ; CNRS - IN2P3 - Université Claude Bernard - Lyon I (UCBL), Laboratoire de l'Accélérateur Linéaire (LAL) ; CNRS - IN2P3 - Université Paris XI - Paris Sud, Laboratoire Leprince-Ringuet (LLR) ; CNRS - IN2P3 - Polytechnique - X, CALICE, Adloff, C., Blaising, J. -J., Chefdeville, M., Drancourt, C., Gaglione, R., Geffroy, N., Karyotakis, Y., Koletsou, I., Prast, J., Vouters, G., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Eigen, G., Thomson, M. A., Ward, D. R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dannheim, D., Dotti, A., Elsener, K., Folger, G., Grefe, C., Ivantchenko, V., Killenberg, M., Klempt, W., Van Der Kraaij, E., Lam, C. B., Linssen, L., Lucaci-Timoce, A. -I., Muennich, A., Poss, S., Ribon, A., Sailer, A., Schlatter, D., Strube, J., Uzhinskiy, V., Carloganu, C., Gay, P., Manen, S., Royer, L., Tytgat, M., Zaganidis, N., Blazey, G. C., Dyshkant, A., Lima, J. G. R., Zutshi, V., Hostachy, J.Y., Morin, L., Cornett, U., David, D., Ebrahimi, A., Falley, G., Feege, N., Gadow, K., Goettlicher, P., Guenter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krueger, K., Lu, S., Lutz, B., Morozov, S., Morgunov, V., Neubueser, C., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Garutti, E., Laurien, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Sudo, Y., Yoshioka, T., Dauncey, P. D., Wing, M., Salvatore, F., Gil, E. Cortina, Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Grenier, G., Han, R., Ianigro, J-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Donckt, M. Vander, Zoccarato, Y., Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Kirikova, N., Kozlov, V., Soloviev, Y., Besson, D., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., Di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., Van Der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., De La Taille, Ch., Poeschl, R., Raux, L., Rouene, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Musat, G., Ruan, M., Tran, T. H., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Kotera, K., Takeshita, T., Uozumi, S., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Goetze, M., Sauer, J., Weber, S., Zeitnitz, C., Laboratoire d'Annecy le Vieux de Physique des Particules (LAPP) ; CNRS - IN2P3 - Université de Savoie, European Organization for Nuclear Research (CERN) ; CERN, Laboratoire de Physique Corpusculaire [Clermont-Ferrand] (LPC) ; CNRS - IN2P3 - Université Blaise Pascal - Clermont-Ferrand II, Laboratoire de Physique Subatomique et de Cosmologie (LPSC) ; CNRS - IN2P3 - Université Joseph Fourier - Grenoble I - Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Institut de Physique Nucléaire de Lyon (IPNL) ; CNRS - IN2P3 - Université Claude Bernard - Lyon I (UCBL), Laboratoire de l'Accélérateur Linéaire (LAL) ; CNRS - IN2P3 - Université Paris XI - Paris Sud, Laboratoire Leprince-Ringuet (LLR) ; CNRS - IN2P3 - Polytechnique - X, CALICE, Adloff, C., Blaising, J. -J., Chefdeville, M., Drancourt, C., Gaglione, R., Geffroy, N., Karyotakis, Y., Koletsou, I., Prast, J., Vouters, G., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Eigen, G., Thomson, M. A., Ward, D. R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dannheim, D., Dotti, A., Elsener, K., Folger, G., Grefe, C., Ivantchenko, V., Killenberg, M., Klempt, W., Van Der Kraaij, E., Lam, C. B., Linssen, L., Lucaci-Timoce, A. -I., Muennich, A., Poss, S., Ribon, A., Sailer, A., Schlatter, D., Strube, J., Uzhinskiy, V., Carloganu, C., Gay, P., Manen, S., Royer, L., Tytgat, M., Zaganidis, N., Blazey, G. C., Dyshkant, A., Lima, J. G. R., Zutshi, V., Hostachy, J.Y., Morin, L., Cornett, U., David, D., Ebrahimi, A., Falley, G., Feege, N., Gadow, K., Goettlicher, P., Guenter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krueger, K., Lu, S., Lutz, B., Morozov, S., Morgunov, V., Neubueser, C., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Garutti, E., Laurien, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Sudo, Y., Yoshioka, T., Dauncey, P. D., Wing, M., Salvatore, F., Gil, E. Cortina, Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Grenier, G., Han, R., Ianigro, J-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Donckt, M. Vander, Zoccarato, Y., Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Kirikova, N., Kozlov, V., Soloviev, Y., Besson, D., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., Di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., Van Der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., De La Taille, Ch., Poeschl, R., Raux, L., Rouene, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Musat, G., Ruan, M., Tran, T. H., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Kotera, K., Takeshita, T., Uozumi, S., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Goetze, M., Sauer, J., Weber, S., and Zeitnitz, C.

Abstract

28 pages, 23 figures, 3 tables, Lepton colliders are considered as options to complement and to extend the physics programme at the Large Hadron Collider. The Compact Linear Collider (CLIC) is an $e^+e^-$ collider under development aiming at centre-of-mass energies of up to 3 TeV. For experiments at CLIC, a hadron sampling calorimeter with tungsten absorber is proposed. Such a calorimeter provides sufficient depth to contain high-energy showers, while allowing a compact size for the surrounding solenoid. A fine-grained calorimeter prototype with tungsten absorber plates and scintillator tiles read out by silicon photomultipliers was built and exposed to particle beams at CERN. Results obtained with electrons, pions and protons of momenta up to 10 GeV are presented in terms of energy resolution and shower shape studies. The results are compared with several GEANT4 simulation models in order to assess the reliability of the Monte Carlo predictions relevant for a future experiment at CLIC.

34. Shower development of particles with momenta from 1 to 10 GeV in the CALICE Scintillator-Tungsten HCAL

Author

Laboratoire d'Annecy le Vieux de Physique des Particules (LAPP) ; CNRS - IN2P3 - Université de Savoie, European Organization for Nuclear Research (CERN) ; CERN, Laboratoire de Physique Corpusculaire [Clermont-Ferrand] (LPC) ; CNRS - IN2P3 - Université Blaise Pascal - Clermont-Ferrand II, Laboratoire de Physique Subatomique et de Cosmologie (LPSC) ; CNRS - IN2P3 - Université Joseph Fourier - Grenoble I - Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Institut de Physique Nucléaire de Lyon (IPNL) ; CNRS - IN2P3 - Université Claude Bernard - Lyon I (UCBL), Laboratoire de l'Accélérateur Linéaire (LAL) ; CNRS - IN2P3 - Université Paris XI - Paris Sud, Laboratoire Leprince-Ringuet (LLR) ; CNRS - IN2P3 - Polytechnique - X, CALICE, Adloff, C., Blaising, J. -J., Chefdeville, M., Drancourt, C., Gaglione, R., Geffroy, N., Karyotakis, Y., Koletsou, I., Prast, J., Vouters, G., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Eigen, G., Thomson, M. A., Ward, D. R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dannheim, D., Dotti, A., Elsener, K., Folger, G., Grefe, C., Ivantchenko, V., Killenberg, M., Klempt, W., Van Der Kraaij, E., Lam, C. B., Linssen, L., Lucaci-Timoce, A. -I., Muennich, A., Poss, S., Ribon, A., Sailer, A., Schlatter, D., Strube, J., Uzhinskiy, V., Carloganu, C., Gay, P., Manen, S., Royer, L., Tytgat, M., Zaganidis, N., Blazey, G. C., Dyshkant, A., Lima, J. G. R., Zutshi, V., Hostachy, J.Y., Morin, L., Cornett, U., David, D., Ebrahimi, A., Falley, G., Feege, N., Gadow, K., Goettlicher, P., Guenter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krueger, K., Lu, S., Lutz, B., Morozov, S., Morgunov, V., Neubueser, C., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Garutti, E., Laurien, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Sudo, Y., Yoshioka, T., Dauncey, P. D., Wing, M., Salvatore, F., Gil, E. Cortina, Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Grenier, G., Han, R., Ianigro, J-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Donckt, M. Vander, Zoccarato, Y., Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Kirikova, N., Kozlov, V., Soloviev, Y., Besson, D., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., Di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., Van Der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., De La Taille, Ch., Poeschl, R., Raux, L., Rouene, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Musat, G., Ruan, M., Tran, T. H., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Kotera, K., Takeshita, T., Uozumi, S., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Goetze, M., Sauer, J., Weber, S., Zeitnitz, C., Laboratoire d'Annecy le Vieux de Physique des Particules (LAPP) ; CNRS - IN2P3 - Université de Savoie, European Organization for Nuclear Research (CERN) ; CERN, Laboratoire de Physique Corpusculaire [Clermont-Ferrand] (LPC) ; CNRS - IN2P3 - Université Blaise Pascal - Clermont-Ferrand II, Laboratoire de Physique Subatomique et de Cosmologie (LPSC) ; CNRS - IN2P3 - Université Joseph Fourier - Grenoble I - Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Institut de Physique Nucléaire de Lyon (IPNL) ; CNRS - IN2P3 - Université Claude Bernard - Lyon I (UCBL), Laboratoire de l'Accélérateur Linéaire (LAL) ; CNRS - IN2P3 - Université Paris XI - Paris Sud, Laboratoire Leprince-Ringuet (LLR) ; CNRS - IN2P3 - Polytechnique - X, CALICE, Adloff, C., Blaising, J. -J., Chefdeville, M., Drancourt, C., Gaglione, R., Geffroy, N., Karyotakis, Y., Koletsou, I., Prast, J., Vouters, G., Repond, J., Schlereth, J., Smith, J., Xia, L., Baldolemar, E., Li, J., Park, S. T., Sosebee, M., White, A. P., Yu, J., Eigen, G., Thomson, M. A., Ward, D. R., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Dannheim, D., Dotti, A., Elsener, K., Folger, G., Grefe, C., Ivantchenko, V., Killenberg, M., Klempt, W., Van Der Kraaij, E., Lam, C. B., Linssen, L., Lucaci-Timoce, A. -I., Muennich, A., Poss, S., Ribon, A., Sailer, A., Schlatter, D., Strube, J., Uzhinskiy, V., Carloganu, C., Gay, P., Manen, S., Royer, L., Tytgat, M., Zaganidis, N., Blazey, G. C., Dyshkant, A., Lima, J. G. R., Zutshi, V., Hostachy, J.Y., Morin, L., Cornett, U., David, D., Ebrahimi, A., Falley, G., Feege, N., Gadow, K., Goettlicher, P., Guenter, C., Hartbrich, O., Hermberg, B., Karstensen, S., Krivan, F., Krueger, K., Lu, S., Lutz, B., Morozov, S., Morgunov, V., Neubueser, C., Reinecke, M., Sefkow, F., Smirnov, P., Terwort, M., Garutti, E., Laurien, S., Marchesini, I., Matysek, M., Ramilli, M., Briggl, K., Eckert, P., Harion, T., Schultz-Coulon, H. -Ch., Shen, W., Stamen, R., Bilki, B., Norbeck, E., Northacker, D., Onel, Y., Wilson, G. W., Kawagoe, K., Sudo, Y., Yoshioka, T., Dauncey, P. D., Wing, M., Salvatore, F., Gil, E. Cortina, Mannai, S., Baulieu, G., Calabria, P., Caponetto, L., Combaret, C., Della Negra, R., Grenier, G., Han, R., Ianigro, J-C., Kieffer, R., Laktineh, I., Lumb, N., Mathez, H., Mirabito, L., Petrukhin, A., Steen, A., Tromeur, W., Donckt, M. Vander, Zoccarato, Y., Alamillo, E. Calvo, Fouz, M. -C., Puerta-Pelayo, J., Corriveau, F., Bobchenko, B., Chadeeva, M., Danilov, M., Epifantsev, A., Markin, O., Mizuk, R., Novikov, E., Popov, V., Rusinov, V., Tarkovsky, E., Kirikova, N., Kozlov, V., Soloviev, Y., Besson, D., Buzhan, P., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Tikhomirov, V., Kiesling, C., Seidel, K., Simon, F., Soldner, C., Szalay, M., Tesar, M., Weuste, L., Amjad, M. S., Bonis, J., Callier, S., Di Lorenzo, S. Conforti, Cornebise, P., Doublet, Ph., Dulucq, F., Fleury, J., Frisson, T., Van Der Kolk, N., Li, H., Martin-Chassard, G., Richard, F., De La Taille, Ch., Poeschl, R., Raux, L., Rouene, J., Seguin-Moreau, N., Anduze, M., Balagura, V., Boudry, V., Brient, J-C., Cornat, R., Frotin, M., Gastaldi, F., Guliyev, E., Haddad, Y., Magniette, F., Musat, G., Ruan, M., Tran, T. H., Videau, H., Bulanek, B., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Lednicky, D., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Ghazlane, H., Kotera, K., Takeshita, T., Uozumi, S., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Goetze, M., Sauer, J., Weber, S., and Zeitnitz, C.

Abstract

28 pages, 23 figures, 3 tables, Lepton colliders are considered as options to complement and to extend the physics programme at the Large Hadron Collider. The Compact Linear Collider (CLIC) is an $e^+e^-$ collider under development aiming at centre-of-mass energies of up to 3 TeV. For experiments at CLIC, a hadron sampling calorimeter with tungsten absorber is proposed. Such a calorimeter provides sufficient depth to contain high-energy showers, while allowing a compact size for the surrounding solenoid. A fine-grained calorimeter prototype with tungsten absorber plates and scintillator tiles read out by silicon photomultipliers was built and exposed to particle beams at CERN. Results obtained with electrons, pions and protons of momenta up to 10 GeV are presented in terms of energy resolution and shower shape studies. The results are compared with several GEANT4 simulation models in order to assess the reliability of the Monte Carlo predictions relevant for a future experiment at CLIC.

35. Brain glucose utilization in systemic lupus erythematosus with neuropsychiatric symptoms: A controlled positron emission tomography study

Author

Otte, A., Weiner, S., Peter, H., Mueller-Brand, J., Goetze, M., Moser, E., Gutfleische, J., Hoegerle, S., Juengling, F., Nitzsche, E., Otte, A., Weiner, S., Peter, H., Mueller-Brand, J., Goetze, M., Moser, E., Gutfleische, J., Hoegerle, S., Juengling, F., and Nitzsche, E.

Abstract

In contrast to morphological imaging [such as magnetic resonance imaging (MRI) or computed tomography], functional imaging may be of advantage in the detection of brain abnormalities in cases of neuropsychiatric systemic lupus erythematosus (SLE). Therefore, we studied 13 patients (aged 40±14 years, 11 female, 2 male) with neuropsychiatric SLE who met four of the American Rheumatism Association criteria for the classification of SLE. Ten clinically and neurologically healthy volunteers served as controls (aged 40±12 years, 5 female, 5 male). Both groups were investigated using fluorine-18-labelled fluorodeoxyglucose brain positron emission tomography (PET) and cranial MRI. The normal controls and 11 of the 13 patients showed normal MRI scans. However, PET scan was abnormal in all 13 SLE patients. Significant group-to-group differences in the glucose metabolic index (GMI=region of interest uptake/global uptake at the level of the basal ganglia and thalamus) were found in the parieto-occipital region on both sides: the GMI of the parieto-occipital region on the right side was 0.922±0.045 in patients and 1.066±0.081 in controls (P<0.0001, Mann WhitneyU test), while on the left side it was 0.892±0.060 in patients and 1.034±0.051 in controls (P=0.0002). Parietooccipital hypometabolism is a conspicuous finding in mainly MRI-negative neuropsychiatric SLE. As the parieto-occipital region is located at the boundary of blood supply of all three major arteries, it could be the most vulnerable zone of the cerebrum and may be affected at an early stage of the cerebrovascular disease

38. Relationship between Pharmacological Treatment Strategy and Cognitive Function in Geriatric Patients with Atrial Fibrillation.

Author

Goetze M, Knauf T, and Ebelt H

Abstract

Background and question: Atrial fibrillation (AF) is the most common cardiac arrhythmia in the total population. The aim of this study is to determine how geriatric patients with AF are treated in terms of rhythm or rate control and whether a relationship between the type of treatment and Mini Mental Status (MMS) can be identified., Methods: In this monocentric, prospective, observational study, data including chronic medication as well as demographic parameters were collected from all patients in a geriatric department between April 2021 and April 2022. A 12-lead ECG as well as the Mini Mental Status were recorded for all patients as part of the admission routine, and a 24 h ECG was performed in selected patients on the basis of clinical indication., Results: At baseline, 715 out of 1914 patients (37.4%) had a known history of AF. Of these patients, 43 patients (6%) were on rhythm control therapy (RHY) and 672 (94%) were on rate control therapy (RATE). No difference in respect to MMS could be detected between RHY and RATE. However, linear regression analyses showed that age, HASBLED score, creatinine serum level, and an existing antiplatelet medication were associated with a negative influence on MMS, whereas oral anticoagulation (OAC) was associated with improved MMS, respectively ( p < 0.05 for all)., Conclusion: The vast majority of geriatric patients with AF are treated with a rate control strategy. Oral anticoagulation is associated with better results in MMS, whereas patients who are treated with antiplatelet medication show worse results in MMS instead.

Published
2023
Full Text
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39. Global rheophytes data set: angiosperms and gymnosperms.

Author

Costa LMS, Goetze M, Rodrigues AV, Seger GDDS, and Bered F

Subjects
Australia, Borneo, China, Humans, Mexico, Phylogeny, Tasmania, Cycadopsida genetics, Magnoliopsida
Abstract

The term rheophyte describes a biological group of flood-tolerant plants that are confined to the beds of swift-running streams and rivers in nature and grow up to flood level, but not beyond the reach of regularly occurring flash floods. Although over 35 yr have passed since the first global census of rheophytes, no updates have been recorded regarding the number of taxa in this biological group in seed plants. Therefore, the present work aimed to (1) review the main topics associated with rheophytism (e.g., morphological characteristics, genetic studies, geographic distribution, conservation, and evolutionary aspects); (2) provide an updated checklist of rheophytes distributed around the world considering the two main groups in seed plants (gymnosperms and angiosperms); (3) demonstrate the distribution of rheophytism in the angiosperm phylogeny; and (4) estimate the geographical distribution and richness of selected taxa on the world map for the first time. All data compiled for the present study originated from a search of peer-reviewed articles, secondary literature (theses, dissertations, reports, books, and floras), and electronic facilities. We compiled a data set composed of four taxa in gymnosperms (Podocarpaceae family) and 1,368 taxa (including obligate, facultative, and unclassified rheophytes) distributed in 114 families and 508 genera in angiosperms. Most of the studied taxa belong to eudicotyledons (72.81%), while 1.46% belong to magnoliids, and 25.73% belong to monocotyledons. The families with the highest number of taxa in descending order are Podostemaceae, Araceae, Myrtaceae, Rubiaceae, Asteraceae, Apocynaceae, Arecaceae, Fabaceae, Phyllanthaceae, and Poaceae. Of the 114 families plotted in angiosperm phylogeny, at least 80 harbor obligate rheophytes. The geographical distribution of rheophytes in angiosperms, as expected based on the first census of this biological group, is mainly in the tropical and subtropical regions. The high richness of rheophytic taxa was mostly found in southern Mexico, southern China, Borneo, and northern and eastern Australia. In contrast, the geographical distribution of rheophytes in gymnosperms is restricted to New Caledonia and Tasmania. The present study will help to advance knowledge regarding the diversity of rheophytes in angiosperms and gymnosperms while drawing attention to this biological group, which has often been overlooked. There are no copyright restrictions. Please cite this data paper when the data are used in publications and teaching events., (© 2020 by the Ecological Society of America.)

Published
2020
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40. Gait Classification in Unilateral Cerebral Palsy.

Author

Tsitlakidis S, Horsch A, Schaefer F, Westhauser F, Goetze M, Hagmann S, and Klotz MCM

Abstract

As unilateral cerebral palsy represents a complex disorder, gait classification is difficult. Knowledge of the most frequent gait patterns and functional impairment is crucial for proper decision-making. This study analyzes the prevalence of gait patterns as well as the relation of different gait patterns and the Gross Motor Function Classification System (GMFCS). Eighty-nine patients were classified retrospectively using the GMFCS, the classification of Winters, Gage, and Hicks (WGH), and Sutherland et al. The distribution of GMFCS levels among the different gait patterns was analyzed using Chi-squared test. The most common subtypes were GMFCS level I, WGH type I, and recurvatum knee. Seventeen percent (WGH) and 59% (Sutherland) of the patients did not match any criteria. Applying both classifications complementarily reduced the number of unclassified patients significantly. There was no significant difference concerning the distribution of GMFCS levels or age among the different gait patterns. A combined use of various classification systems is beneficial for proper decision-making. Unclassified patients seem to be a heterogeneous subgroup concerning functional impairment. There is a need of further characterization of the unclassifiable gait patterns and the caused functional impairment. Instrumented gait analysis remains the gold standard and should be broadly used for future studies and in clinical practice.

Published
2019
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41. Ecological niche modeling and a lack of phylogeographic structure in Vriesea incurvata suggest historically stable areas in the southern Atlantic Forest.

Author

Aguiar-Melo C, Zanella CM, Goetze M, Palma-Silva C, Hirsch LD, Neves B, da Costa AF, and Bered F

Subjects
Brazil, Climate, Haplotypes, Phylogeography, Bromeliaceae genetics, Ecosystem, Gene Flow, Genetic Variation, Models, Biological
Abstract

Premise: Despite the efforts to understand the processes that shape neotropical biodiversity, the complexity of certain biomes, such as the Atlantic Forest (AF), prevents the generalization of patterns. Initially, ecological niche modeling (ENM), with phylogeographic studies, identified past stable areas in the central and northern portions of the AF, while the southern portion was thought to be highly fragmented. Here, we examined the phylogeography, historical patterns, genetic diversity, and population structure of Vriesea incurvata, an endemic species of the southern portion of the AF., Methods: We evaluated 149 individuals using two plastid DNA regions (cpDNA) and 13 nuclear microsatellite markers (nuSSRs) to access the historical patterns, genetic diversity, and structure of V. incurvata populations. We also conducted historical demography and ENM analyses., Results: We found moderate to high genetic diversity and low population structure for both genomes. The cpDNA network revealed high haplotype sharing. The ENM suggested no drastic changes in suitable areas for V. incurvata occurrence, corroborating the finding of no phylogeographic structure., Conclusions: Contrary to some studies, our results indicate that the southern AF was a historically stable climate region for V. incurvata occupation after southward colonization by the species. Past climatic changes probably did not cause structuring among its populations., (© 2019 Botanical Society of America.)

Published
2019
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42. ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest.

Author

Ramos FN, Mortara SR, Monalisa-Francisco N, Elias JPC, Neto LM, Freitas L, Kersten R, Amorim AM, Matos FB, Nunes-Freitas AF, Alcantara S, Alexandre MHN, de Almeida-Scabbia RJ, de Almeida OJG, Alves FE, de Oliveira Alves RM, Alvim FS, de Andrade ACS, de Andrade S, Aona LYS, Araujo AC, de Araújo KCT, Ariati V, Assis JC, de Azevedo CO, Barbosa BF, Barbosa DEF, Barbosa FDR, de Barros F, Basilio GA, Bataghin FA, Bered F, Bianchi JS, Blum CT, Boelter CR, Bonnet A, Brancalion PHS, Breier TB, Brion CT, Buzatto CR, Cabral A, Cadorin TJ, Caglioni E, Canêz L, Cardoso PH, de Carvalho FS, Carvalho RG, Catharino ELM, Ceballos SJ, Cerezini MT, César RG, Cestari C, Chaves CJN, Citadini-Zanette V, Coelho LFM, Coffani-Nunes JV, Colares R, Colletta GD, Corrêa NM, da Costa AF, da Costa GM, Costa LMS, Costa NGS, Couto DR, Cristofolini C, da Cruz ACR, Del Neri LA, di Pasquo M, Dos Santos Dias A, Dias LDCD, Dislich R, Duarte MC, Fabricante JR, Farache FHA, de Faria APG, Faxina C, Ferreira MTM, Fischer E, Fonseca CR, Fontoura T, Francisco TM, Furtado SG, Galetti M, Garbin ML, de Gasper AL, Goetze M, Gomes-da-Silva J, Gonçalves MFA, Gonzaga DR, Silva ACGE, Guaraldo AC, Guarino ESG, Guislon AV, Hudson LB, Jardim JG, Jungbluth P, Kaeser SDS, Kessous IM, Koch NM, Kuniyoshi YS, Labiak PH, Lapate ME, Santos ACL, Leal RLB, Leite FS, Leitman P, Liboni AP, Liebsch D, Lingner DV, Lombardi JA, Lucas E, Luzzi JDR, Mai P, Mania LF, Mantovani W, Maragni AG, Marques MCM, Marquez G, Martins C, Martins LDN, Martins PLSS, Mazziero FFF, Melo CA, de Melo MMF, Mendes AF, Mesacasa L, Morellato LPC, Moreno VS, Muller A, Murakami MMDS, Cecconello E, Nardy C, Nervo MH, Neves B, Nogueira MGC, Nonato FR, de Oliveira-Filho AT, de Oliveira CPL, Overbeck GE, Marcusso GM, Paciencia MLB, Padilha P, Padilha PT, Pereira ACA, Pereira LC, Pereira RAS, Pincheira-Ulbrich J, Pires JSR, Pizo MA, Pôrto KC, Rattis L, Reis JRM, Reis SGD, da Rocha-Pessôa TC, Rocha CFD, Rocha FS, Rodrigues ARP, Rodrigues RR, Rogalski JM, Rosanelli RL, Rossado A, Rossatto DR, Rother DC, Ruiz-Miranda CR, Saiter FZ, Sampaio MB, Santana LD, Santos JSD, Sartorello R, Sazima M, Schmitt JL, Schneider G, Schroeder BG, Sevegnani L, Júnior VOS, da Silva FR, da Silva MJ, Silva MPP, Silva RG, Silva SM, Singer RB, Siqueira G, Soares LE, de Sousa HC, Spielmann A, Tonetti VR, Toniato MTZ, Ulguim PSB, van den Berg C, van den Berg E, Varassin IG, da Silva IBV, Vibrans AC, Waechter JL, Weissenberg EW, Windisch PG, Wolowski M, Yañez A, Yoshikawa VN, Zandoná LR, Zanella CM, Zanin EM, Zappi DC, Zipparro VB, Zorzanelli JPF, and Ribeiro MC

Abstract

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events., (© 2019 The Authors. Ecology © 2019 The Ecological Society of America.)

Published
2019
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43. Development, characterization, and transferability of SSR markers for Vriesea carinata (Bromeliaceae) based on RNA sequencing.

Author

Todeschini CC, Parizotto JLB, Guzman F, Zanella CM, Margis R, Goetze M, Paggi GM, Santana Costa LM, de Aguiar Melo C, Hirsch LD, and Bered F

Abstract

Premise of the Study: Expressed sequence tag-simple sequence repeat (EST-SSR) markers were isolated for Vriesea carinata , an endemic bromeliad from the Brazilian Atlantic Forest. These SSR loci may be used to investigate the genetic diversity and population structure of this species and related bromeliads., Methods and Results: Based on the transcriptome data of V. carinata , 30 primer pairs were designed and selected for initial validation. Of these primer pairs, 16 generated suitable SSR loci in 69 individuals. The number of alleles per locus ranged from one to 13; the levels of observed and expected heterozygosity per locus ranged from 0.000 to 1.000 and from 0.000 to 0.935, respectively. All loci produced heterologous amplification. Transferability of the loci was tested in 15 species belonging to three Bromeliaceae subfamilies., Conclusions: The developed EST-SSR markers revealed polymorphism in the four studied populations and could be useful to investigate the genetic diversity of V. carinata and related species. The markers may also be suitable for novel gene annotation and discovery.

Published
2018
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44. Genetic diversity and population structure of Vriesea reitzii (Bromeliaceae), a species from the Southern Brazilian Highlands.

Author

Soares LE, Goetze M, Zanella CM, and Bered F

Abstract

The Southern Brazilian Highlands are composed by a mosaic of Mixed Ombrophilous Forest (MOF) and grassland formations, an interesting landscape for the study of population structure. We analyzed the genetic diversity within and among populations of the MOF-endemic bromeliad Vriesea reitzii by genotyping seven nuclear microsatellite loci in 187 individuals from six populations. We characterized levels of genetic diversity and assessed the genetic structure among populations. Vriesea reitzii populations showed high levels of genetic variation (number of alleles 28 - 43, allelic richness 3.589 - 5.531) and moderate levels of genetic differentiation (FST = 0.123, RST = 0.096). The high levels of genetic diversity may be explained by species life-history traits, such as habit and mating system. The moderate structure may be a product of the combination of ancient and contemporary gene flow, resulting from the expansion of the forest in the Holocene, and/or due to facilitated dispersal mediated by the MOF's mosaic landscape. The genetic results indicated no imminent threat to this bromeliad. However, the species is highly associated with the MOF, putting landscape conservation at the center of conservation efforts for the species' maintenance.

Published
2018
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45. Incomplete lineage sorting and hybridization in the evolutionary history of closely related, endemic yellow-flowered Aechmea species of subgenus Ortgiesia (Bromeliaceae).

Author

Goetze M, Zanella CM, Palma-Silva C, Büttow MV, and Bered F

Subjects
Biological Evolution, Brazil, Bromeliaceae genetics, Genetics, Population, Haplotypes, Phylogeography, Sequence Analysis, DNA, Bromeliaceae classification, Genetic Variation, Hybridization, Genetic, Phylogeny
Abstract

Premise of the Study: The yellow-flowered Aechmea subgenus Ortgiesia (yfAsO) (Bromeliaceae) is a group of seven morphologically similar bromeliads found mostly in the southern Brazilian Atlantic rainforest. The recent origin of this group probably contributes to its taxonomic complexity. The aims of this study were to investigate the levels of genetic diversity and structure at the population and species levels, to gain insight into the processes behind the diversification of the group, and to contribute to the establishment of species boundaries., Methods: We sequenced two noncoding regions of the chloroplast genome ( rpl32-trnL and rps16-trnK ) and the nuclear phyC gene in 204 and 153 individuals, respectively, representing the seven species of the group. Phylogeographical and population genetics approaches were used., Key Results: Three of the seven yfAsO showed some degree of genetic differentiation among species. Divergence time for the group was dated to around 4 million years ago. Areas of conservation value were identified, and a scenario of multiple refugia in the southern Brazilian Atlantic rainforest during the Pleistocene climatic oscillations is suggested., Conclusions: We hypothesized that incomplete lineage sorting and localized hybridization events are responsible for the low levels of genetic differentiation and the taxonomic complexity observed among and within the seven yfAsO species. Further studies on Aechmea comata and Aechmea kertesziae will be necessary to clarify the boundary between these two species. Most of the populations sampled showed high genetic diversity and/or unique haplotypes; they should be prioritized for conservation purposes., (© 2017 Botanical Society of America.)

Published
2017
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46. Diversification of Bromelioideae (Bromeliaceae) in the Brazilian Atlantic rainforest: A case study in Aechmea subgenus Ortgiesia.

Author

Goetze M, Schulte K, Palma-Silva C, Zanella CM, Büttow MV, Capra F, and Bered F

Subjects
Argentina, Atlantic Ocean, Brazil, Bromeliaceae anatomy & histology, Bromeliaceae physiology, Hybridization, Genetic, Inflorescence classification, Inflorescence genetics, Inflorescence physiology, Paraguay, Uruguay, Amplified Fragment Length Polymorphism Analysis, Bromeliaceae classification, Bromeliaceae genetics, Phylogeny, Polymorphism, Genetic genetics, Rainforest
Abstract

Aechmea subgenus Ortgiesia comprises ca. 20 species distributed in Brazil, Argentina, Paraguay, and Uruguay, with a center of diversity in the Brazilian Atlantic rainforest. We examined interspecific relationships of Ortgiesia based on Amplified Fragment Length Polymorphisms (AFLP). Ninety-six accessions belonging to 14 species of Ortgiesia were sampled, and genotyped with 11 AFLP primer combinations. The neighbor joining (NJ) tree depicted two main genetic groups within Aechmea subgenus Ortgiesia, and four subgroups. The NJ tree showed short internal branches, indicating an overall shallow genetic divergence among Ortgiesia species as expected for the recently radiated subfamily Bromelioideae. Our results suggest that hybridization and/or incomplete lineage sorting may have hampered the reconstruction of interspecific relationships in Aechmea subgenus Ortgiesia. The mapping of petal color (yellow, blue, pink, or white), inflorescence type (simple or compound), and inflorescence shape (ellipsoid, subcylindric, cylindric, or pyramidal) against the NJ tree indicated that these characters are of limited taxonomic use in Aechmea subgenus Ortgiesia due to homoplasy. An analysis of the current distribution of Ortgiesia identified the southern region of the Brazilian Atlantic rainforest, between latitudes of 26° and 27°S, as the center of diversity for the subgenus., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2016
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47. Genetics, evolution and conservation of Bromeliaceae.

Author

Zanella CM, Janke A, Palma-Silva C, Kaltchuk-Santos E, Pinheiro FG, Paggi GM, Soares LE, Goetze M, Büttow MV, and Bered F

Abstract

Bromeliaceae is a morphologically distinctive and ecologically diverse family originating in the New World. Three centers of diversity, 58 genera, and about 3,140 bromeliad species are currently recognized. We compiled all of the studies related to the reproductive biology, genetic diversity, and population structure of the Bromeliaceae, and discuss the evolution and conservation of this family. Bromeliads are preferentially pollinated by vertebrates and show marked variation in breeding systems, from predominant inbreeding to predominant outcrossing, as well as constancy in chromosome number (2n = 2x = 50). Autogamous or mixed mating system bromeliads have a high inbreeding coefficient (F(IS)), while outcrossing species show low F(IS). The degree of differentiation among populations (F(ST))of species ranges from 0.043 to 0.961, which can be influenced by pollen and seed dispersal effects, clonal growth, gene flow rates, and connectivity among populations. The evolutionary history of the Bromeliaceae is poorly known, although some studies have indicated that the family arose in the Guayana Shield roughly 100 Mya. We believe that genetic, cytogenetic, and reproductive data will be essential for diagnosing species status and for assisting conservation programs.

Published
2012
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48. Microsatellites in the endangered species Dyckia distachya (Bromeliaceae) and cross-amplification in other bromeliads.

Author

Zanella CM, Janke A, Paggi GM, Goetze M, Reis MS, and Bered F

Subjects
Bromeliaceae genetics, Endangered Species, Genetic Loci, Microsatellite Repeats, Polymorphism, Genetic
Abstract

Microsatellite markers were isolated in Dyckia distachya, an endangered bromeliad from southern Brazil, which will be useful to assess the population genetic structure and reproductive success in introduced and natural populations of this species. Twenty microsatellite loci were developed from an enriched genomic library, and nine of these were amplified. The loci were characterized in 43 individuals from introduced and wild D. distachya populations. All nine loci were polymorphic, with four to ten alleles per locus. In an introduced population the observed and expected heterozygosities ranged from 0.136-0.667 and 0.543-0.877, respectively, while in a wild population it ranged from 0.000 to 0.895 and from 0.050 to 0.811, respectively. The development of these microsatellite markers will contribute to investigations of the reproductive potential and viability of introduced populations of D. distachya as well as the single known wild population. Cross-amplification in other Bromeliaceae species was successful, with high rates in four loci, demonstrating the applicability of these microsatellite markers in other taxa.

Published
2012
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49. Genetic structure and phenotypic variation in wild populations of the medicinal tetraploid species Bromelia antiacantha (Bromeliaceae).

Author

Zanella CM, Bruxel M, Paggi GM, Goetze M, Buttow MV, Cidade FW, and Bered F

Subjects
Base Sequence, DNA Primers, Genes, Plant, Genetic Variation, Bromelia genetics, Polyploidy
Abstract

Premise of the Study: The patterns of genetic structure in plant populations are mainly related to the species life history and breeding system, and knowledge of these patterns is necessary for the management, use, and conservation of biological diversity. Polyploidy is considered an important mode of evolution in plants, but few studies have evaluated genetic structure of polyploid populations. We studied the patterns of genetic structure and morphological variation of Bromelia antiacantha (Bromeliaceae) populations, a polyploid terrestrial species. •, Methods: Microsatellite markers and morphological analyses were used to explore patterns of genetic and morphological diversity in wild populations of B. antiacantha. •, Key Results: The results of our simple-sequence repeat analyses supported that B. antiacantha is a polyploid species. The inbreeding coefficients were high and significant in all populations (F(IS) = 0.431), indicating homozygote excess. Bromelia antiacantha showed high levels of genetic differentiation among populations (F(ST) = 0.224) and therefore was highly structured. High morphological variation was observed in fruit phenotypic traits in the populations studied. •, Conclusions: The levels of genetic diversity and the pattern of the population's structure may be related to the low recruitment of seeds, clonal reproduction, and the population's colonization history. The genetic and morphological variability displayed in this study are important issues in planning the conservation and exploitation of this resource in a sustainable way.

Published
2011
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50. Development of an indirect ELISA-NcSRS2 for detection of Neospora caninum antibodies in cattle.

Author

Borsuk S, Andreotti R, Leite FP, Pinto Lda S, Simionatto S, Hartleben CP, Goetze M, Oshiro LM, Matos Mde F, and Berne ME

Subjects
Animals, Cattle, Cattle Diseases blood, Cattle Diseases diagnosis, Coccidiosis blood, Coccidiosis diagnosis, Coccidiosis parasitology, Enzyme-Linked Immunosorbent Assay methods, Sensitivity and Specificity, Antibodies, Protozoan blood, Cattle Diseases parasitology, Coccidiosis veterinary, Enzyme-Linked Immunosorbent Assay veterinary, Neospora immunology
Abstract

Neosporosis is of alarming economic concern in the cattle industry. The effectiveness of diagnostic tests for detecting specific antibodies against Neospora caninum is hampered by potential cross-reaction with other coccidia. Use of a single specific antigen might improve test specificity. An indirect enzyme-linked immunosorbent assay (ELISA) was developed using the truncated protein NcSRS2 expressed in Escherichia coli. The ELISA results were compared with those of the indirect fluorescence antibody test (IFAT). Receiver Operating Characteristic (ROC) and Tests in the Absence of a Gold Standard (TAGS) analysis revealed an assay having 96% specificity and 95% sensitivity when applied to 145 positive and 352 negative sera from two distinct cattle populations. Using OD ≤ 0.095 as the cut-off point, the assay's negative and positive predictive values ranged from 98.8% to 50.8% and from 58.8% to 99.1%, respectively, depending on neosporosis prevalence in a given area. The novel ELISA-NcSRS2 format described in the present report constitutes a specific and sensitive method for detecting N. caninum in cattle., (Copyright © 2010 Elsevier B.V. All rights reserved.)

Published
2011
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