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10. Peripheral BDNF - what do we learn from this?

Author

Meeusen, Romain, Goekint, Maaike, Bos, Inge, Knaepen, Kristel, Fontenelle, Vinciane, Roelands, Bart, and Human Physiology and Special Physiology of Physical Education

Abstract

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Published
2010

12. BDNF, exercise and monoaminergic neurotransmission

Author

Goekint, Maaike, Bos, Inge, Meeusen, Romain, Michotte, Yvette, Sarre, Sophie, Pharmaceutical Chemistry, Drug Analysis and Drug Information, and Human Physiology and Special Physiology of Physical Education

Abstract

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Published
2010

16. No Influence Of Administration Of A Selective Noradrenaline Re-uptake Inhibitor On The Acute Exerciseinduced Increase In Serum Bdnf In Healthy Men

Author

Goekint, Maaike, Heyman, Elsa, Roelands, Bart, Njemini, Rose, Bautmans, Ivan, Mets, Tony, Meeusen, Romain, Frailty in Ageing, and Human Physiology and Special Physiology of Physical Education

Abstract

PURPOSE: Monoamines, especially noradrenaline, seem to be important in brainderived neurotrophic factor (BDNF) gene regulation with exercise [1]. In animals, administration of reboxetine has already been shown to increase BDNF [2]. However, it is not known if the monoamine-induced increase in BDNF during exercise is also present in humans. Therefore, we examined the influence of a noradrenaline re-uptake inhibitor on the exercise-induced increase in serum BDNF in humans. METHODS: Eleven well trained male subjects (age 22.9 ± 4.3 years; maximal power output (Wmax) 338.6 ± 31.8 W) performed 2 trials, consisting of 60 min cycling at of Wmax, followed by a time trial (TT) at 75% of Wattmax. The exercise was performed after having taken either reboxetine or placebo. Heart rate and ratings of perceived exertion (RPE) on a Borg scale were measured. Blood samples were taken at 4 time points to analyze peripheral BDNF and cortisol. Data were analysed using ANOVA repeated measures (PRESULTS: Serum BDNF increased following exercise (PCONCLUSIONS: Serum BDNF increases following strenuous acute exercise, but no additional influence on peripheral BDNF levels was seen with reboxetine treatment. Reboxetine, however, influenced cortisol levels during exercise and performance of the subjects. New studies should focus on the effect of regular physical activity in combination with antidepressants on BDNF levels.

Published
2008

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