1. Gas chromatographic determination of propylene glycol dinitrate in rodent skin
- Author
-
Godin Cs and Pollard Dl
- Subjects
Male ,Chromatography, Gas ,Health, Toxicology and Mutagenesis ,Skin Absorption ,Ethyl acetate ,Otto fuel II ,Toxicology ,Polyvinyl alcohol ,Analytical Chemistry ,law.invention ,chemistry.chemical_compound ,law ,Environmental Chemistry ,Flame ionization detector ,Animals ,Skin ,Chemical Health and Safety ,Chromatography ,Chemistry ,Extraction (chemistry) ,Rats, Inbred F344 ,Rats ,Standard curve ,Propylene Glycols ,Gas chromatography ,Propylene glycol dinitrate - Abstract
A gas chromatographic (GC) method was developed for the detection of propylene glycol dinltrate (PGDN) in rodent skin following extraction with ethyl acetate. Known quantities of PGDN contained In the torpedo fuel Otto Fuel II were added to homogenates of rat skin, which were subsequently extracted with two 10-mL portions of ethyl acetate. An aliquot of each extract was analyzed by GC with a flame Ionization detector. With this method, concentrations ranging from 0.0042 to 11.2 mg/mL were determined by comparison with a standard curve. The extraction efflclencles ranged from 85.7% for the lowest concentration to 101% for the highest concentration.
- Published
- 1992