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19 results on '"Goda, Marwa S."'

2. Antimicrobial Potential of Different Isolates of Chaetomium globosum Combined with Liquid Chromatography Tandem Mass Spectrometry Chemical Profiling

Author

Goda, Marwa S., primary, El-Kattan, Noura, additional, Abdel-Azeem, Mohamed A., additional, Allam, Kamilia A. M., additional, Badr, Jihan M., additional, Nassar, Nourelhuda Ahmed, additional, Almalki, Ahmad J., additional, Alharbi, Majed, additional, Elhady, Sameh S., additional, and Eltamany, Enas E., additional

Published
2023
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4. Comparative Estimation of the Cytotoxic Activity of Different Parts of Cynara scolymus L.: Crude Extracts versus Green Synthesized Silver Nanoparticles with Apoptotic Investigation

Author

Khedr, Amgad I. M., primary, Farrag, Abdelaziz F. S., additional, Nasr, Ali M., additional, Swidan, Shady A., additional, Nafie, Mohamed S., additional, Abdel-Kader, Maged S., additional, Goda, Marwa S., additional, Badr, Jihan M., additional, and Abdelhameed, Reda F. A., additional

Published
2022
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6. Silver Nanoparticles Formulation of Flower Head’s Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

Author

Khedr, Amgad I. M., primary, Goda, Marwa S., additional, Farrag, Abdelaziz F. S., additional, Nasr, Ali M., additional, Swidan, Shady A., additional, Nafie, Mohamed S., additional, Abdel-Kader, Maged S., additional, Badr, Jihan M., additional, and Abdelhameed, Reda F. A., additional

Published
2022
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8. GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea

Author

Elhady, Sameh S., primary, Ibrahim, Elsayed A., additional, Goda, Marwa S., additional, Nafie, Mohamed S., additional, Samir, Hanan, additional, Diri, Reem M., additional, Alahdal, Abdulrahman M., additional, Thomford, Ama Kyeraa, additional, El Gindy, Alaa, additional, Hadad, Ghada M., additional, Badr, Jihan M., additional, and Abdelhameed, Reda F. A., additional

Published
2022
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9. Comparative Assessment of the Antioxidant and Anticancer Activities of Plicosepalus acacia and Plicosepalus curviflorus: Metabolomic Profiling and In Silico Studies

Author

Eltamany, Enas E., primary, Goda, Marwa S., additional, Nafie, Mohamed S., additional, Abu-Elsaoud, Abdelghafar M., additional, Hareeri, Rawan H., additional, Aldurdunji, Mohammed M., additional, Elhady, Sameh S., additional, Badr, Jihan M., additional, and Eltahawy, Nermeen A., additional

Published
2022
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11. Metabolic Profiling, Chemical Composition, Antioxidant Capacity, and In Vivo Hepato- and Nephroprotective Effects of Sonchus cornutus in Mice Exposed to Cisplatin

Author

Elhady, Sameh S., primary, Abdelhameed, Reda F. A., additional, Mehanna, Eman T., additional, Wahba, Alaa Samir, additional, Elfaky, Mahmoud A., additional, Koshak, Abdulrahman E., additional, Noor, Ahmad O., additional, Bogari, Hanin A., additional, Malatani, Rania T., additional, and Goda, Marwa S., additional

Published
2022
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12. Anticancer Effects of New Ceramides Isolated from the Red Sea Red Algae Hypnea musciformis in a Model of Ehrlich Ascites Carcinoma: LC-HRMS Analysis Profile and Molecular Modeling

Author

Elhady, Sameh S., primary, Habib, Eman S., additional, Abdelhameed, Reda F. A., additional, Goda, Marwa S., additional, Hazem, Reem M., additional, Mehanna, Eman T., additional, Helal, Mohamed A., additional, Hosny, Khaled M., additional, Diri, Reem M., additional, Hassanean, Hashim A., additional, Ibrahim, Amany K., additional, Eltamany, Enas E., additional, Abdelmohsen, Usama Ramadan, additional, and Ahmed, Safwat A., additional

Published
2022
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16. Thalassosterol, a New Cytotoxic Aromatase Inhibitor Ergosterol Derivative from the Red Sea Seagrass Thalassodendron ciliatum

Author

Abdelhameed, Reda F. A., Habib, Eman S., Goda, Marwa S., Fahim, John Refaat, Hassanean, Hashem A., Eltamany, Enas E., Ibrahim, Amany K., AboulMagd, Asmaa M., Fayez, Shaimaa, El-kader, Adel M. Abd, Al-Warhi, Tarfah, Bringmann, Gerhard, Ahmed, Safwat A., and Abdelmohsen, Usama Ramadan

Subjects
ergosterol derivative, metabolic analysis, Thalassodendron ciliatum, lcsh:Biology (General), seagrass, ddc:540, docking studies, lcsh:QH301-705.5, cytotoxic activity
Abstract

Thalassodendron ciliatum (Forssk.) Den Hartog is a seagrass belonging to the plant family Cymodoceaceae with ubiquitous phytoconstituents and important pharmacological potential, including antioxidant, antiviral, and cytotoxic activities. In this work, a new ergosterol derivative named thalassosterol (1) was isolated from the methanolic extract of T. ciliatum growing in the Red Sea, along with two known first-reported sterols, namely ergosterol (2) and stigmasterol (3), using different chromatographic techniques. The structure of the new compound was established based on 1D and 2D NMR spectroscopy and high-resolution mass spectrometry (HR-MS) and by comparison with the literature data. The new ergosterol derivative showed significant in vitro antiproliferative potential against the human cervical cancer cell line (HeLa) and human breast cancer (MCF-7) cell lines, with IC50 values of 8.12 and 14.24 &micro, M, respectively. In addition, docking studies on the new sterol 1 explained the possible binding interactions with an aromatase enzyme, this inhibition is beneficial in both cervical and breast cancer therapy. A metabolic analysis of the crude extract of T. ciliatum using liquid chromatography combined with high-resolution electrospray ionization mass spectrometry (LC-ESI-HR-MS) revealed the presence of an array of phenolic compounds, sterols and ceramides, as well as di- and triglycerides.

Published
2020

17. Thalassosterol, a New Cytotoxic Aromatase Inhibitor Ergosterol Derivative from the Red Sea Seagrass Thalassodendron ciliatum

Author

Abdelhameed, Reda F. A., primary, Habib, Eman S., additional, Goda, Marwa S., additional, Fahim, John Refaat, additional, Hassanean, Hashem A., additional, Eltamany, Enas E., additional, Ibrahim, Amany K., additional, AboulMagd, Asmaa M., additional, Fayez, Shaimaa, additional, El-kader, Adel M. Abd, additional, Al-Warhi, Tarfah, additional, Bringmann, Gerhard, additional, Ahmed, Safwat A., additional, and Abdelmohsen, Usama Ramadan, additional

Published
2020
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18. In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification.

Author

Goda, Marwa S., Nafie, Mohamed S., Awad, Basma M., Abdel-Kader, Maged S., Ibrahim, Amany K., Badr, Jihan M., and Eltamany, Enas E.

Subjects
LIQUID chromatography-mass spectrometry, EPIDERMAL growth factor receptors, HIGH performance liquid chromatography, POLYPHENOLS
Abstract

Artemisia judaica L. (Family: Asteraceae) exhibited antioxidant, anti-inflammatory, and antiapoptotic effects. The in vitro cytotoxic activity of A. judaica ethanolic extract was screened against a panel of cancer cell lines. The results revealed its cytotoxic activity against a lung cancer (A549) cell line with a promising IC50 of 14.2 μg/mL compared to doxorubicin as a standard. This was confirmed through the downregulation of antiapoptotic genes, the upregulation of proapoptotic genes, and the cell cycle arrest at the G2/M phase. Further in vivo study showed that a solid tumor mass was significantly reduced, with a tumor inhibition ratio of 54% relative to doxorubicin therapy in a Xenograft model. From a chemical point of view, various classes of natural products have been identified by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS). The docking study of the detected metabolites approved their cytotoxic activity through their virtual binding affinity towards the cyclin-dependent kinase 2 (CDK-2) and epidermal growth factor receptor (EGFR) active sites. Finally, A. judaica is a fruitful source of polyphenols that are well-known for their antioxidant and cytotoxic activities. As such, the previously reported polyphenols with anti-lung cancer activity were quantified by high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD). Rutin, quercetin, kaempferol, and apigenin were detected at concentrations of 6 mg/gm, 0.4 mg/gm, 0.36 mg/gm, and 3.9 mg/gm of plant dry extract, respectively. It is worth noting that kaempferol and rutin are reported for the first time. Herein, A. judaica L. may serve as an adjuvant therapy or a promising source of leading structures in drug discovery for lung cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Anticancer Effects of New Ceramides Isolated from the Red Sea Red Algae Hypnea   musciformis in a Model of Ehrlich Ascites Carcinoma: LC-HRMS Analysis Profile and Molecular Modeling.

Author

Elhady SS, Habib ES, Abdelhameed RFA, Goda MS, Hazem RM, Mehanna ET, Helal MA, Hosny KM, Diri RM, Hassanean HA, Ibrahim AK, Eltamany EE, Abdelmohsen UR, and Ahmed SA

Subjects
Animals, Antineoplastic Agents chemistry, Antineoplastic Agents therapeutic use, Aquatic Organisms, Ascites pathology, Carcinoma, Ehrlich Tumor pathology, Cell Line, Tumor drug effects, Ceramides chemistry, Ceramides therapeutic use, Disease Models, Animal, Humans, Indian Ocean, Inhibitory Concentration 50, Mice, Molecular Docking Simulation, Antineoplastic Agents pharmacology, Carcinoma, Ehrlich Tumor drug therapy, Ceramides pharmacology, Rhodophyta
Abstract

Different classes of phytochemicals were previously isolated from the Red Sea algae Hypnea   musciformis as sterols, ketosteroids, fatty acids, and terpenoids. Herein, we report the isolation of three fatty acids-docosanoic acid 4 , hexadecenoic acid 5 , and alpha hydroxy octadecanoic acid 6 -as well as three ceramides- A ( 1 ), B ( 2 ), and C ( 3 )-with 9-methyl-sphinga-4,8-dienes and phytosphingosine bases. Additionally, different phytochemicals were determined using the liquid chromatography coupled with electrospray ionization high-resolution mass spectrometry (LC-ESI-HRMS) technique. Ceramides A ( 1 ) and B ( 2 ) exhibited promising in vitro cytotoxic activity against the human breast adenocarcinoma (MCF-7) cell line when compared with doxorubicin as a positive control. Further in vivo study and biochemical estimation in a mouse model of Ehrlich ascites carcinoma (EAC) revealed that both ceramides A ( 1 ) and B ( 2 ) at doses of 1 and 2 mg/kg, respectively, significantly decreased the tumor size in mice inoculated with EAC cells. The higher dose (2 mg/kg) of ceramide B ( 2 ) particularly expressed the most pronounced decrease in serum levels of vascular endothelial growth factor -B (VEGF-B) and tumor necrosis factor-α (TNF-α) markers, as well as the expression levels of the growth factor midkine in tumor tissue relative to the EAC control group. The highest expression of apoptotic factors, p53, Bax, and caspase 3 was observed in the same group that received 2 mg/kg of ceramide B ( 2 ). Molecular docking simulations suggested that ceramides A ( 1 ) and B ( 2 ) could bind in the deep grove between the H2 helix and the Ser240-P250 loop of p53, preventing its interaction with MDM2 and leading to its accumulation. In conclusion, this study reports the cytotoxic, apoptotic, and antiangiogenic effects of ceramides isolated from the Red Sea algae Hypnea   musciformis in an experimental model of EAC.

Published
2022
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