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6. Urinary Steroid Profile In Early Pregnancy After In Vitro Fertilization

Author

Biro, Ildiko, Bufa, Anita, Wilhelm, Ferenc, Manfai, Zoltan, Kilar, Ferenc, and Gocze, Peter Miklos

Abstract

Objective. The aim of the study was to compare the levels of urinary steroid metabolites of patients with successful in vitro fertilization and patients who failed to achieve pregnancy. Design. Comparison of urinary steroid profiles prior to oocyte pick-up and three weeks after embryo transfer. Setting. University hospital. Sample. Eleven women in the same age range with pregnancy after in vitro fertilization and eleven women who failed to achieve pregnancy. Methods. The standard long protocol was used for ovarian stimulation and intracytoplasmic sperm injection for assisted in vitro fertilization. The steroid metabolites in urine samples collected for 24 h were determined by gas chromatographymass spectrometry. Main outcome measures. Steroid metabolite levels in urine samples determined in the early pregnancy period. Results. The levels of androsterone, etiocholanolone, pregnanediol, tetrahydro-11-dehydrocorticosterone and tetrahydro-corticosterone were significantly higher (p < 0.05) in the urine of women with successful pregnancy three weeks after the embryo transfer, while the levels of tetrahydrocortisone, tetrahydrocortisol, allo-tetrahydrocortisol and a-cortolone became higher in the group of patients with unsuccessful pregnancy. Conclusions. The production of androgens, progesterone and corticoid steroid metabolites is altered in the early pregnancy period after in vitro fertilization.

Published
2012

11. CA-125 as a screening test for ovarian cancer

Author

Gocze, Peter M., Freeman, Dale A., Helzlsouer, Kathy J., Alberg, Anthony J., Bush, Trudy L., and Comstock, George W.

Subjects
Ovarian cancer -- Diagnosis, Medical screening -- Methods, Tumor markers -- Measurement
Published
1993

12. Smoking cessation and risk of stroke in women

Author

Chin, David L., Gocze, Peter M., Laszik, Zoltan, Feigenbaum, Lawrence Z., Longstreth, W.T., Jr., Nelson, Lorene M., Kawachi, Ichiro, Colditz, Graham A., Stampfer, Meir J., Willett, Walter C., and Speizer, Frank E.

Subjects
Smoking and women -- Health aspects, Stroke (Disease) -- Risk factors
Published
1993

23. Indications for Hysterectomy.

Author

Gocze, Peter M.

Subjects
*LETTERS to the editor, *HYSTERECTOMY
Abstract

A letter to the editor is presented in response to the article "Indications for Hysterectomy," by Karen J. Carlson, David H. Nichols and Isaac Schiff in the March 25, 1993 issue.

Published
1993
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24. MicroRNA expressions in HPV-induced cervical dysplasia and cancer.

Author

Gocze K, Gombos K, Kovacs K, Juhasz K, Gocze P, and Kiss I

Subjects
Adolescent, Adult, Aged, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell virology, Female, Gene Expression, Humans, MicroRNAs genetics, Middle Aged, Papillomavirus Infections, Up-Regulation, Uterine Cervical Dysplasia genetics, Uterine Cervical Dysplasia virology, Uterine Cervical Neoplasms genetics, Uterine Cervical Neoplasms virology, Young Adult, Carcinoma, Squamous Cell metabolism, MicroRNAs metabolism, Uterine Cervical Dysplasia metabolism, Uterine Cervical Neoplasms metabolism
Abstract

Background/aim: The role of oncogenic or high-risk human papillomavirus (HPV) in cervical carcinogenesis is inevitable, yet not fully understood. Detailed analysis of microRNA (miRNA) alterations occurring during high-risk HPV transformation will increase our current understanding over cervical carcinogenesis. The two main aims of the study were: (i) finding association between HPV infection characteristics and socio-demographic variables, (ii) finding an predictors of clinical outcome., Materials and Methods: The expression levels of different microRNAs (miR-21, miR-27a, miR-34a, miR-155, miR-196a, miR-203) were determined in formalin-fixed paraffin-embedded (FFPE) human HPV-positive cervical dysplastic and tumorous tissue samples using quantitative real-time PCR (qPCR). Sociodemographic and life-style factors were also analyzed., Results: The expression of miR-27a was significantly higher in cervical intraepithelial neoplasia (CIN)2-3 compared to CIN1 (p=0.023) and in squamous cell carcinoma (SCC) compared to CIN2-3 (p=0.033). Moreover, significantly lower levels of miR-34a were detected in CIN2-3 than in CIN1 (p=0.041) and in SCC than in CIN2-3 (p=0.021). Furthermore, we found significant differences in subjects with multiple HPV in miR-27a (p=0.015) and miR-203 (p=0.025) in CIN2-3 compared to CIN1 and miR-21 (p=0.002), mir-27a (p=0.001) and miR-34a (p=0.001) in SCC/CIN2-3. Expression of miR-27a, showing up-regulation in CIN2-3 compared to CIN1 (p=0.028) and miR-34a (down-regulated), correlated with HPV 16 positivity (CIN2-3/CIN1: p=0.027 and SCC/CIN2-3: p=0.036). MiR-34a expression was also significantly altered in connection to smoking status and presence of HPV 16., Conclusion: The demand for additional, alternative molecular biomarkers with prognostic potential is strong. Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome., (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

25. Unique microRNA expression profiles in cervical cancer.

Author

Gocze K, Gombos K, Juhasz K, Kovacs K, Kajtar B, Benczik M, Gocze P, Patczai B, Arany I, and Ember I

Subjects
Adenocarcinoma metabolism, Adenocarcinoma pathology, Adenocarcinoma virology, Carcinoma, Squamous Cell metabolism, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell virology, Cervix Uteri metabolism, Female, Genotype, Humans, MicroRNAs genetics, Neoplasm Grading, Papillomaviridae classification, Papillomaviridae genetics, Papillomavirus Infections genetics, Papillomavirus Infections pathology, Uterine Cervical Neoplasms metabolism, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms virology, Adenocarcinoma genetics, Carcinoma, Squamous Cell genetics, MicroRNAs biosynthesis, Papillomavirus Infections virology, Uterine Cervical Neoplasms genetics
Abstract

Cervical cancer is the second leading cause of death among female patients with cancer in the world. Our aim was to analyze cervical cancer cases, in the Southwestern Transdanubian Region of Hungary, with regard to human papillomavirus (HPV) genotype and histological and clinical grading. After HPV testing and genotyping, the expressions of eight different pre-microRNAs (miR-21, miR-27a, miR-34a, miR-146a, miR-155, miR-196a, miR-203, miR-221) in formalin-fixed paraffin-embedded (FFPE) primary human cervical cancer samples were evaluated with the help of the LightCycler 480 PCR System (Roche). Statistically significant overexpression of miR-21 (p=0.004), miR-27a (p=0.018), miR-34a (p<0.001), miR-155 (p=0.021), miR-196a (p=0.032), miR-203 (p=0.037) and miR-221 (p=0.017) were observed in squamous cell carcinoma, regardless of HPV status and clinical grading. Significant overexpression of miR-21 (p=0.004), miR-27a (p=0.02), miR-34a (p<0.001), miR-196a (p=0.027) and miR-221 (p=0.031) was characteristic of HPV-positive squamous cell carcinomas in contrast to adenocarcinomas of the same HPV status.

Published
2013

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