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3. Identification of New, Translatable ProtectomiRs against Myocardial Ischemia/Reperfusion Injury and Oxidative Stress: The Role of MMP/Biglycan Signaling Pathways.

Author

Szabados, Tamara, Molnár, Arnold, Kenyeres, Éva, Gömöri, Kamilla, Pipis, Judit, Pósa, Bence, Makkos, András, Ágg, Bence, Giricz, Zoltán, Ferdinandy, Péter, Görbe, Anikó, and Bencsik, Péter

Subjects
REPERFUSION injury, MYOCARDIAL ischemia, CELLULAR signal transduction, MYOCARDIAL infarction, LABORATORY rats, MYOCARDIAL perfusion imaging, OXIDATIVE stress, IDENTIFICATION
Abstract

Introduction: Ischemic conditionings (ICon) were intensively investigated and several protective signaling pathways were identified. Previously, we have shown the role of matrix metalloproteinases (MMP) in myocardial ischemia/reperfusion injury (MIRI) and the cardioprotective role of biglycan (BGN), a small leucine-rich proteoglycan in vitro. Here, we hypothesized that cardiac MMP and BGN signaling are involved in the protective effects of ICon. Methods: A reverse target-microRNA prediction was performed by using the miRNAtarget™ 2.0 software to identify human microRNAs with a possible regulatory effect on MMP and BGN, such as on related genes. To validate the identified 1289 miRNAs in the predicted network, we compared them to two cardioprotective miRNA omics datasets derived from pig and rat models of MIRI in the presence of ICons. Results: Among the experimentally measured miRNAs, we found 100% sequence identity to human predicted regulatory miRNAs in the case of 37 porcine and 24 rat miRNAs. Upon further analysis, 42 miRNAs were identified as MIRI-associated miRNAs, from which 24 miRNAs were counter-regulated due to ICons. Conclusions: Our findings highlight 24 miRNAs that potentially regulate cardioprotective therapeutic targets associated with MMPs and BGN in a highly translatable porcine model of acute myocardial infarction. [ABSTRACT FROM AUTHOR]

Published
2024
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6. An Observational Study on the Pharmacokinetics of Oseltamivir in Lactating Influenza Patients.

Author

Fodor, Eszter, Nagy, Regina N., Nógrádi, András, Toovey, Stephen, Kamal, Mohamed A., Vadász, Péter, Bencsik, Péter, Görbe, Anikó, and Ferdinandy, Péter

Subjects
BREASTFEEDING, OSELTAMIVIR, INFLUENZA, BREAST milk, PUERPERAL disorders, LACTATION
Abstract

Influenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating women with acute influenza infection, and the consequent infant exposure to oseltamivir are still unknown, and these data would help in assessing risk and the need for dose adjustment in breastfed infants. Six lactating women with influenza‐like symptoms, at a standard dose of 75 mg oral oseltamivir twice daily for 5 days, were recruited in this phase IV clinical study during the 2011/2012 H1N1 pandemic seasons. Breast milk/colostrum and venous blood samples were taken at multiple timepoints, maternal urine samples were obtained from total output within the 12‐hour observational period following the seventh dose of oseltamivir. Oseltamivir phosphate (OP) reached a maximum 69.5 ± 29.4 ng/mL concentration in breast milk, higher than that found in the plasma, and showed elimination within ~ 8 hours. Oseltamivir carboxylate (active metabolite of OP) showed a lower, nearly steady‐state concentration in breast milk during the observational period (maximum plasma concentration (Cmax) = 38.4 ± 12.9 ng/mL). Based on estimated daily milk consumption of exclusively breastfed infants, their calculated daily exposure is < 0.1% of the infant dose of oseltamivir for treatment of influenza as per marketing authorization. Here, we provide the first maternal breast milk pharmacokinetic data for oral multiple‐dose oseltamivir in lactating patients with influenza and showed that its concentration in the breast milk is not sufficient to reach a therapeutic dose for breastfed infants. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction

Author

Sayour, Nabil V., primary, Tóth, Viktória É., additional, Nagy, Regina N., additional, Vörös, Imre, additional, Gergely, Tamás G., additional, Onódi, Zsófia, additional, Nagy, Noémi, additional, Bödör, Csaba, additional, Váradi, Barnabás, additional, Ruppert, Mihály, additional, Radovits, Tamás, additional, Bleckwedel, Federico, additional, Zelarayán, Laura C., additional, Pacher, Pal, additional, Ágg, Bence, additional, Görbe, Anikó, additional, Ferdinandy, Péter, additional, and Varga, Zoltán V., additional

Published
2023
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10. Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy

Author

Gömöri, Kamilla, primary, Herwig, Melissa, additional, Hassoun, Roua, additional, Budde, Heidi, additional, Mostafi, Nusratul, additional, Delalat, Simin, additional, Modi, Suvasini, additional, Begovic, Merima, additional, Szabados, Tamara, additional, Pipis, Judit, additional, Farkas-Morvay, Nikolett, additional, Leprán, István, additional, Kovács, Árpád, additional, Mügge, Andreas, additional, Ferdinandy, Péter, additional, Görbe, Anikó, additional, Bencsik, Péter, additional, and Hamdani, Nazha, additional

Published
2022
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11. Rosiglitazone Does Not Show Major Hidden Cardiotoxicity in Models of Ischemia/Reperfusion but Abolishes Ischemic Preconditioning-Induced Antiarrhythmic Effects in Rats In Vivo

Author

Weber, Bennet Y., primary, Brenner, Gábor B., additional, Kiss, Bernadett, additional, Gergely, Tamás G., additional, Sayour, Nabil V., additional, Tian, Huimin, additional, Makkos, András, additional, Görbe, Anikó, additional, Ferdinandy, Péter, additional, and Giricz, Zoltán, additional

Published
2022
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12. MMP Activity Detection in Zymograms

Author

Bencsik, Péter, primary, Bartekova, Monika, additional, Görbe, Anikó, additional, Kiss, Krisztina, additional, Pálóczi, János, additional, Radosinska, Jana, additional, Szűcs, Gergő, additional, and Ferdinandy, Péter, additional

Published
2017
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13. Addition of epidermal growth factor receptor inhibitors to standard chemotherapy increases survival of advanced head and neck squamous cell carcinoma patients: A systematic review and meta‐analysis.

Author

Kiss, Fruzsina, Pohóczky, Krisztina, Görbe, Anikó, Dembrovszky, Fanni, Kiss, Szabolcs, Hegyi, Péter, Szakó, Lajos, Tóth, Lilla, Ezer, Éva Somogyiné, Szalai, Eszter, and Helyes, Zsuzsanna

Subjects
DISEASE progression, META-analysis, MEDICAL information storage & retrieval systems, CONFIDENCE intervals, EPIDERMAL growth factor receptors, CANCER chemotherapy, SYSTEMATIC reviews, MORTALITY, HEAD & neck cancer, ANTINEOPLASTIC agents, CANCER patients, RESEARCH funding, PROGRESSION-free survival, MEDLINE, ODDS ratio, SQUAMOUS cell carcinoma, OVERALL survival
Abstract

Head and neck squamous cell carcinoma (HNSCC) is among the common tumors associated with high mortality. The aim of our meta‐analysis was to determine how additional anti‐epidermal growth factor receptor (EGFR) therapy to standard chemotherapy affects the progression‐free (PFS) and overall survival (OS) of the patients, besides the most common side effects. We used CENTRAL, MEDLINE, and Embase databases until October 26, 2020, and included 13 eligible randomized controlled trials in our systematic research. The pooled hazard ratios (HR) for the main outcomes from the original data were estimated and for the other dichotomous outcomes, odds ratios (ORs) with their 95% confidence intervals (CI) were calculated. Addition of EGFR inhibitors to conventional chemotherapy significantly decreased the death and disease progression (for PFS HR: 0.68, 95% CI: 0.55–0.81, I2 = 65.5%, p = 0.005) and mortality (for OS HR: 0.83, 95% CI: 0.72–0.94, I2 = 42.3%, p = 0.076). In the EGFR inhibitor group, we revealed an increased chance of the over Grade 3 skin rashes (OR: 4.86; 95% CI: 1.52–15.49, I2 = 2.3%, p = 0.407), and all Grade skin rashes (OR: 18.32, 95% CI: 8.07–41.60, I2 = 56.6%, p = 0.032). Despite their unwanted dermatological side effects, the addition of EGFR inhibitors is recommended to be included in advanced HNSCC therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Addition of epidermal growth factor receptor inhibitors to standard chemotherapy increases survival of advanced head and neck squamous cell carcinoma patients: A systematic review and meta‐analysis

Author

Kiss, Fruzsina, primary, Pohóczky, Krisztina, additional, Görbe, Anikó, additional, Dembrovszky, Fanni, additional, Kiss, Szabolcs, additional, Hegyi, Péter, additional, Szakó, Lajos, additional, Tóth, Lilla, additional, Ezer, Éva Somogyiné, additional, Szalai, Eszter, additional, and Helyes, Zsuzsanna, additional

Published
2022
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16. Ca2+/calmodulin‐dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model

Author

Gömöri, Kamilla, primary, Herwig, Melissa, additional, Budde, Heidi, additional, Hassoun, Roua, additional, Mostafi, Nusratul, additional, Zhazykbayeva, Saltanat, additional, Sieme, Marcel, additional, Modi, Suvasini, additional, Szabados, Tamara, additional, Pipis, Judit, additional, Farkas‐Morvay, Nikolett, additional, Leprán, István, additional, Ágoston, Gergely, additional, Baczkó, István, additional, Kovács, Árpád, additional, Mügge, Andreas, additional, Ferdinandy, Péter, additional, Görbe, Anikó, additional, Bencsik, Péter, additional, and Hamdani, Nazha, additional

Published
2022
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18. Systematic transcriptomic and phenotypic characterization of human and murine cardiac myocyte cell lines and primary cardiomyocytes reveals serious limitations and low resemblances to adult cardiac phenotype

Author

Onódi, Zsófia, primary, Visnovitz, Tamás, additional, Kiss, Bernadett, additional, Hambalkó, Szabolcs, additional, Koncz, Anna, additional, Ágg, Bence, additional, Váradi, Barnabás, additional, Tóth, Viktória É., additional, Nagy, Regina N., additional, Gergely, Tamás G., additional, Gergő, Dorottya, additional, Makkos, András, additional, Pelyhe, Csilla, additional, Varga, Nóra, additional, Reé, Dóra, additional, Apáti, Ágota, additional, Leszek, Przemyslaw, additional, Kovács, Tamás, additional, Nagy, Nándor, additional, Ferdinandy, Péter, additional, Buzás, Edit I., additional, Görbe, Anikó, additional, Giricz, Zoltán, additional, and Varga, Zoltán V., additional

Published
2022
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20. Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection

Author

Vörös, Imre, primary, Sághy, Éva, additional, Pohóczky, Krisztina, additional, Makkos, András, additional, Onódi, Zsófia, additional, Brenner, Gábor B., additional, Baranyai, Tamás, additional, Ágg, Bence, additional, Váradi, Barnabás, additional, Kemény, Ágnes, additional, Leszek, Przemyslaw, additional, Görbe, Anikó, additional, Varga, Zoltán V., additional, Giricz, Zoltán, additional, Schulz, Rainer, additional, Helyes, Zsuzsanna, additional, and Ferdinandy, Péter, additional

Published
2021
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22. Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases

Author

Nagy, Anikó, primary, Juhász, Márk Félix, additional, Görbe, Anikó, additional, Váradi, Alex, additional, Izbéki, Ferenc, additional, Vincze, Áron, additional, Sarlós, Patrícia, additional, Czimmer, József, additional, Szepes, Zoltán, additional, Takács, Tamás, additional, Papp, Mária, additional, Fehér, Eszter, additional, Hamvas, József, additional, Kárász, Klaudia, additional, Török, Imola, additional, Stimac, Davor, additional, Poropat, Goran, additional, Ince, Ali Tüzün, additional, Erőss, Bálint, additional, Márta, Katalin, additional, Pécsi, Dániel, additional, Illés, Dóra, additional, Váncsa, Szilárd, additional, Földi, Mária, additional, Faluhelyi, Nándor, additional, Farkas, Orsolya, additional, Nagy, Tamás, additional, Kanizsai, Péter, additional, Márton, Zsolt, additional, Szentesi, Andrea, additional, Hegyi, Péter, additional, and Párniczky, Andrea, additional

Published
2021
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23. Helium Conditioning Increases Cardiac Fibroblast Migration Which Effect Is Not Propagated via Soluble Factors or Extracellular Vesicles

Author

Jelemenský, Marek, primary, Kovácsházi, Csenger, additional, Ferenczyová, Kristína, additional, Hofbauerová, Monika, additional, Kiss, Bernadett, additional, Pállinger, Éva, additional, Kittel, Ágnes, additional, Sayour, Viktor Nabil, additional, Görbe, Anikó, additional, Pelyhe, Csilla, additional, Hambalkó, Szabolcs, additional, Kindernay, Lucia, additional, Barančík, Miroslav, additional, Ferdinandy, Péter, additional, Barteková, Monika, additional, and Giricz, Zoltán, additional

Published
2021
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28. AIM2-driven inflammasome activation in heart failure

Author

Onódi, Zsófia, primary, Ruppert, Mihály, additional, Kucsera, Dániel, additional, Sayour, Alex Ali, additional, Tóth, Viktória E, additional, Koncsos, Gábor, additional, Novák, Julianna, additional, Brenner, Gábor B, additional, Makkos, András, additional, Baranyai, Tamás, additional, Giricz, Zoltán, additional, Görbe, Anikó, additional, Leszek, Przemyslaw, additional, Gyöngyösi, Mariann, additional, Horváth, Iván G, additional, Schulz, Rainer, additional, Merkely, Béla, additional, Ferdinandy, Péter, additional, Radovits, Tamás, additional, and Varga, Zoltán V, additional

Published
2021
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31. Reduction in hypoxia‐reoxygenation‐induced myocardial mitochondrial damage with exogenous methane

Author

Jász, Dávid Kurszán, primary, Szilágyi, Ágnes Lilla, additional, Tuboly, Eszter, additional, Baráth, Bálint, additional, Márton, Anett Roxána, additional, Varga, Petra, additional, Varga, Gabriella, additional, Érces, Dániel, additional, Mohácsi, Árpád, additional, Szabó, Anna, additional, Bozó, Renáta, additional, Gömöri, Kamilla, additional, Görbe, Anikó, additional, Boros, Mihály, additional, and Hartmann, Petra, additional

Published
2021
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36. Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Tocchetti, Carlo Gabriele, Ameri, Pietro, de Boer, Rudolf A, D'Alessandra, Yuri, Russo, Michele, Sorriento, Daniela, Ciccarelli, Michele, Kiss, Bernadett, Bertrand, Luc, Dawson, Dana, Falcao-Pires, Ines, Giacca, Mauro, Hamdani, Nazha, Linke, Wolfgang A, Mayr, Manuel, van der Velden, Jolanda, Zacchigna, Serena, Ghigo, Alessandra, Hirsch, Emilio, Lyon, Alexander R, Görbe, Anikó, Ferdinandy, Péter, Madonna, Rosalinda, Heymans, Stephane, Thum, Thomas, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Tocchetti, Carlo Gabriele, Ameri, Pietro, de Boer, Rudolf A, D'Alessandra, Yuri, Russo, Michele, Sorriento, Daniela, Ciccarelli, Michele, Kiss, Bernadett, Bertrand, Luc, Dawson, Dana, Falcao-Pires, Ines, Giacca, Mauro, Hamdani, Nazha, Linke, Wolfgang A, Mayr, Manuel, van der Velden, Jolanda, Zacchigna, Serena, Ghigo, Alessandra, Hirsch, Emilio, Lyon, Alexander R, Görbe, Anikó, Ferdinandy, Péter, Madonna, Rosalinda, Heymans, Stephane, and Thum, Thomas

Abstract

In western countries, cardiovascular (CV) disease and cancer are the leading causes of death in the ageing population. Recent epidemiological data suggest that cancer is more frequent in patients with prevalent or incident CV disease, in particular, heart failure (HF). Indeed, there is a tight link in terms of shared risk factors and mechanisms between HF and cancer. HF induced by anticancer therapies has been extensively studied, primarily focusing on the toxic effects that anti-tumour treatments exert on cardiomyocytes. In this Cardio-Oncology update, members of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart discuss novel evidence interconnecting cardiac dysfunction and cancer via pathways in which cardiomyocytes may be involved but are not central. In particular, the multiple roles of cardiac stromal cells (endothelial cells and fibroblasts) and inflammatory cells are highlighted. Also, the gut microbiota is depicted as a new player at the crossroads between HF and cancer. Finally, the role of non-coding RNAs in Cardio-Oncology is also addressed. All these insights are expected to fuel additional research efforts in the field of Cardio-Oncology.

Published
2020

37. Az akut pancreatitis utáni szénhidrátanyagcsere-zavar megjelenésének jellegzetességei 3 év követéses vizsgálat során

Author

Mikó, Alexandra, primary, Bódis, Beáta, additional, Kató, Dorottya, additional, Lillik, Veronika, additional, Váncsa, Szilárd, additional, Görbe, Anikó, additional, Hegyi, Péter J., additional, Sarlós, Patrícia, additional, Vincze, Áron, additional, Faluhelyi, Nándor, additional, Gajdán, László, additional, Izbéki, Ferenc, additional, and Hegyi, Péter, additional

Published
2021
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39. Calcium Ionophore-Induced Extracellular Vesicles Mediate Cytoprotection against Simulated Ischemia/Reperfusion Injury in Cardiomyocyte-Derived Cell Lines by Inducing Heme Oxygenase 1

Author

Pečan, Peter, primary, Hambalkó, Szabolcs, additional, Ha, Van Thai, additional, Nagy, Csilla T., additional, Pelyhe, Csilla, additional, Lainšček, Duško, additional, Kenyeres, Bence, additional, Brenner, Gábor B., additional, Görbe, Anikó, additional, Kittel, Ágnes, additional, Barteková, Monika, additional, Ferdinandy, Péter, additional, Manček-Keber, Mateja, additional, and Giricz, Zoltán, additional

Published
2020
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41. Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury

Author

Gáspár, Renáta, primary, Gömöri, Kamilla, additional, Kiss, Bernadett, additional, Szántai, Ágnes, additional, Pálóczi, János, additional, Varga, Zoltán V., additional, Pipis, Judit, additional, Váradi, Barnabás, additional, Ágg, Bence, additional, Csont, Tamás, additional, Ferdinandy, Péter, additional, Barteková, Monika, additional, and Görbe, Anikó, additional

Published
2020
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42. Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Author

Tocchetti, Carlo Gabriele, primary, Ameri, Pietro, additional, de Boer, Rudolf A, additional, D’Alessandra, Yuri, additional, Russo, Michele, additional, Sorriento, Daniela, additional, Ciccarelli, Michele, additional, Kiss, Bernadett, additional, Bertrand, Luc, additional, Dawson, Dana, additional, Falcao-Pires, Ines, additional, Giacca, Mauro, additional, Hamdani, Nazha, additional, Linke, Wolfgang A, additional, Mayr, Manuel, additional, van der Velden, Jolanda, additional, Zacchigna, Serena, additional, Ghigo, Alessandra, additional, Hirsch, Emilio, additional, Lyon, Alexander R, additional, Görbe, Anikó, additional, Ferdinandy, Péter, additional, Madonna, Rosalinda, additional, Heymans, Stephane, additional, and Thum, Thomas, additional

Published
2020
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46. Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion

Author

Brenner, Gábor B., primary, Makkos, András, additional, Nagy, Csilla Terézia, additional, Onódi, Zsófia, additional, Sayour, Nabil V., additional, Gergely, Tamás G., additional, Kiss, Bernadett, additional, Görbe, Anikó, additional, Sághy, Éva, additional, Zádori, Zoltán S., additional, Lázár, Bernadette, additional, Baranyai, Tamás, additional, Varga, Richárd S., additional, Husti, Zoltán, additional, Varró, András, additional, Tóthfalusi, László, additional, Schulz, Rainer, additional, Baczkó, István, additional, Giricz, Zoltán, additional, and Ferdinandy, Péter, additional

Published
2020
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