798 results on '"Go, K."'
Search Results
2. Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood
- Author
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Finik, J., Buthmann, J., Zhang, W., Go, K., and Nomura, Y.
- Published
- 2020
- Full Text
- View/download PDF
3. Occult pneumothorax in blunt trauma: is there a need for tube thoracostomy?
- Author
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Zhang, M., Teo, L. T., Goh, M. H., Leow, J., and Go, K. T. S.
- Published
- 2016
- Full Text
- View/download PDF
4. EPH89 An Individual Patient Data-Based Meta-Analysis of the Relative Reactogenicity of the Infant Doses of Two Licensed Dtap-Backboned Hexavalent Vaccines
- Author
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Vargas-Zambrano, JC, primary, Asvatourian, V, additional, B'Chir, S, additional, Go, K, additional, and Vidor, E, additional
- Published
- 2022
- Full Text
- View/download PDF
5. A multinational Delphi consensus to end the COVID-19 public health threat
- Author
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Lazarus, J. V., Romero, D., Kopka, C. J., Karim, S. A., Abu-Raddad, L. J., Almeida, G., Baptista-Leite, R., Barocas, J. A., Barreto, M. L., Bar-Yam, Y., Bassat, Q., Batista, C., Bazilian, M., Chiou, S. -T., del Rio, C., Dore, G. J., Gao, G. F., Gostin, L. O., Hellard, M., Jimenez, J. L., Kang, G., Lee, N., Maticic, M., Mckee, M., Nsanzimana, S., Oliu-Barton, M., Pradelski, B., Pyzik, O., Rabin, K., Raina, S., Rashid, S. F., Rathe, M., Saenz, R., Singh, S., Trock-Hempler, M., Villapol, S., Yap, P., Binagwaho, A., Kamarulzaman, A., El-Mohandes, A., Barreto, M., Abdulla, S., Addleman, S., Aghayeva, G., Agius, R., Ahmed, M., Ramy, M. A., Aide, P., Aleman, S., Alfred, J. -P., Ali, S., Aliaga, J., Aloudat, T., Alqahtani, S. A., Al-Salman, J., Amuasi, J. H., Agrawal, A., Anwar, W., Araujo-Jorge, T., Artaza, O., Asadi, L., Awuku, Y., Baker, M., Barberia, L., Bascolo, E., Belcher, P., Bell, L., Benzaken, A., Bergholtz, E., Bhadelia, N., Bhan, A., Bilodeau, S., Bitran, R., Bluyssen, P., Bosman, A., Bozza, F. A., Brinkmann, M. M., Brown, A., Mellado, B., Bukusi, E., Bullen, C., Buonanno, G., Burgess, R., Butler, M., Byakika-Kibwika, P., Cabieses, B., Carlsson, G., Cascini, Fidelia, Chabala, C., Chakroun, M., Cheng, K. K., Chetty, A., Chumachenko, D., Consalves, G., Conway Morris, A., Cordie, A., Corrah, T., Crabtree-Ramirez, B., Dashdorj, N., Davidovitch, N., de Souza, L. E., Dhariwal, A. C., Druica, E., Ergonul, O., Erondu, N. A., Essar, M. Y., Ewing, A., Fanjul, G., Feierstein, D., Feigl-Ding, E., Figueroa, R., Figueroa, J. P., Fisher, D., Flores, W., Forero-Pena, D. A., Frumkin, H., Gamkrelidze, A., Gandhi, M., Garcia, P., Garcia-Basteiro, A. L., Garcia-Sastre, A., Garg, S., Gbeasor-Komlanvi, F. A., Gershenson, C., Gilada, I., Giovanella, L., Gonzalez, M., Green, M. S., Greenhalgh, T., Griffin, P., Griffin, S., Grinsztejn, B., Anand, T., Guerra, G., Guinto, R., Gujski, M., Guner, R., Hamdy, A., Hancean, M. -G., Haniffa, A., Hartigan-Go, K. Y., Hassan, H. K., Hay, S. I., Heino, M. T. J., Hel, Z., Hotez, P., Hu, J., Hukic, M., Ijsselmuiden, C., Iroko, D., Iskarous, M., Izugbara, C., Jacobs, C., Jadad, A. R., Jehan, F., Jordan, A., Jroundi, I., Kain, K., Kamberi, F., Karamov, E., Karan, A., Katz, R., Katzourakis, A., Kazembe, A., Khamis, F., Khamzayev, K., Khanyola, J., Khunti, K., Kiguli-Malwadde, E., Kim, W. J., Kirenga, B. J., Klimovsky, D., Kmush, B. L., Knaul, F., Kogevinas, M., Kristensen, F., Kumar, D., Kumar, R., Kvalsvig, A., Lacerda, M. V., Lal, A., Lawton, T., Lemery, J., Leonardi, A. J., Li, Y., Lottvall, J., Lounis, M., Maceira, D., Macintyre, C. R., Madani, A., Magiorkinis, G., Malekzadeh, R., Choisy, M., Marcelin, J. R., Marks, G. B., Marr, L., Marrazzo, J., Martina, A., Martin-Moreno, J. M., Mateos, C., Mayxay, M., Mazarati, J. B., Mboup, S., Mcdonald, J., Mcmillan, F., Mechili, E., Medici, A., Davis, S. L. M., Meier, P., Memish, Z. A., Menon, J., Menon, P., Mesiano-Crookston, J., Michie, S., Mikolasevic, I., Milicevic, O., Mishra, A. K., Mohamed, R., Mokdad, A. H., Monroy-Valle, M., Morawska, L., Moschos, S. A., Motawea, K., Mousavi, S. H., Mumtaz, G., Munene, P. K., Munoz Almagro, C., Muriuki, J., Muyingo, S., Naniche, D., Naylor, C. D., Ndembi, N., Nemec, J., Nesteruk, I., Ngaruiya, C., Nguyen, H., Nikolova, D., Nitzan, D., Norheim, O., Noushad, M., Ntoumi, F., Nyborg, G. A., Ochodo, E., Odabasi, Z., Okwen, M. P., Olivia, K., Ong, D. S. Y., Opara, I., Orozco, M., Oshitani, H., Pagel, C., Pai, M., Palsdottir, B., Papatheodoridis, G., Paraskevis, D., Leigh, J. P., Pecoul, B., Peichl, A., Perez-Then, E., Duc, P. P., Philippe, C., Pineda Rojas, A., Pladsen, C., Pozniak, A., Quiroga, R., Qureshi, H., Rampal, S., Ranney, M., Rathe, L., Ratzan, S., Raventos, H., Rees, H., Reis, R., Ricciardi, Walter, Rizk, N., Robalo, M., Robertson, E., Robinson, L., Rokx, C., Ros, T., Rottingen, J. -A., Rubin, M., Ruxrungtam, K., Sadirova, S., Saha, S., Salgado, N., Sanchez, L., Sangaramoorthy, T., Santamaria-Ulloa, C., Santos, R., Sawaf, B., Schneider, M. F., Schooley, R. T., Sener, A., Sepulveda, J., Shah, J., Shibani, M., Shoib, S., Sikazwe, I., Simaitis, A., Gill, A. S., Skhvitaridze, N., Sokolovic, M., Solomon, R., Solorzano, X., Springer, S. A., Srol, J., Staines, A., Stelfox, H. T., Strathdee, S., Sulaiman, L. H., Sutton, B., Svanaes, D., Swed, S., Sypsa, V., Sorensen, K., Tajudeen, R., Tan, A., Tang, J., Tanner, M., Sethi, T., Temmerman, M., Than, K. K., Tinto, H., Tometissi, S. P., Torres, I., Tshering, K. P., Tsiodras, S., Tsofa, B., Vahlne, A., Vargas, J. R., Bernal, I. D. V., Ventura, D., Vilasanjuan, R., Vipond, J., Wamala-Andersson, S., Wargocki, P., West, R., Weyand, A., White, T. M., Wolff, G., Yao, M., Yates, C. A., Yeboah, G., Yee-Sin, L., Yi, S., Teo, Y. -Y., Yong, P., Zamora-Mesia, V., Ovrehus, A., Cascini F. (ORCID:0000-0001-6499-0734), Ricciardi W. (ORCID:0000-0002-5655-688X), Lazarus, J. V., Romero, D., Kopka, C. J., Karim, S. A., Abu-Raddad, L. J., Almeida, G., Baptista-Leite, R., Barocas, J. A., Barreto, M. L., Bar-Yam, Y., Bassat, Q., Batista, C., Bazilian, M., Chiou, S. -T., del Rio, C., Dore, G. J., Gao, G. F., Gostin, L. O., Hellard, M., Jimenez, J. L., Kang, G., Lee, N., Maticic, M., Mckee, M., Nsanzimana, S., Oliu-Barton, M., Pradelski, B., Pyzik, O., Rabin, K., Raina, S., Rashid, S. F., Rathe, M., Saenz, R., Singh, S., Trock-Hempler, M., Villapol, S., Yap, P., Binagwaho, A., Kamarulzaman, A., El-Mohandes, A., Barreto, M., Abdulla, S., Addleman, S., Aghayeva, G., Agius, R., Ahmed, M., Ramy, M. A., Aide, P., Aleman, S., Alfred, J. -P., Ali, S., Aliaga, J., Aloudat, T., Alqahtani, S. A., Al-Salman, J., Amuasi, J. H., Agrawal, A., Anwar, W., Araujo-Jorge, T., Artaza, O., Asadi, L., Awuku, Y., Baker, M., Barberia, L., Bascolo, E., Belcher, P., Bell, L., Benzaken, A., Bergholtz, E., Bhadelia, N., Bhan, A., Bilodeau, S., Bitran, R., Bluyssen, P., Bosman, A., Bozza, F. A., Brinkmann, M. M., Brown, A., Mellado, B., Bukusi, E., Bullen, C., Buonanno, G., Burgess, R., Butler, M., Byakika-Kibwika, P., Cabieses, B., Carlsson, G., Cascini, Fidelia, Chabala, C., Chakroun, M., Cheng, K. K., Chetty, A., Chumachenko, D., Consalves, G., Conway Morris, A., Cordie, A., Corrah, T., Crabtree-Ramirez, B., Dashdorj, N., Davidovitch, N., de Souza, L. E., Dhariwal, A. C., Druica, E., Ergonul, O., Erondu, N. A., Essar, M. Y., Ewing, A., Fanjul, G., Feierstein, D., Feigl-Ding, E., Figueroa, R., Figueroa, J. P., Fisher, D., Flores, W., Forero-Pena, D. A., Frumkin, H., Gamkrelidze, A., Gandhi, M., Garcia, P., Garcia-Basteiro, A. L., Garcia-Sastre, A., Garg, S., Gbeasor-Komlanvi, F. A., Gershenson, C., Gilada, I., Giovanella, L., Gonzalez, M., Green, M. S., Greenhalgh, T., Griffin, P., Griffin, S., Grinsztejn, B., Anand, T., Guerra, G., Guinto, R., Gujski, M., Guner, R., Hamdy, A., Hancean, M. -G., Haniffa, A., Hartigan-Go, K. Y., Hassan, H. K., Hay, S. I., Heino, M. T. J., Hel, Z., Hotez, P., Hu, J., Hukic, M., Ijsselmuiden, C., Iroko, D., Iskarous, M., Izugbara, C., Jacobs, C., Jadad, A. R., Jehan, F., Jordan, A., Jroundi, I., Kain, K., Kamberi, F., Karamov, E., Karan, A., Katz, R., Katzourakis, A., Kazembe, A., Khamis, F., Khamzayev, K., Khanyola, J., Khunti, K., Kiguli-Malwadde, E., Kim, W. J., Kirenga, B. J., Klimovsky, D., Kmush, B. L., Knaul, F., Kogevinas, M., Kristensen, F., Kumar, D., Kumar, R., Kvalsvig, A., Lacerda, M. V., Lal, A., Lawton, T., Lemery, J., Leonardi, A. J., Li, Y., Lottvall, J., Lounis, M., Maceira, D., Macintyre, C. R., Madani, A., Magiorkinis, G., Malekzadeh, R., Choisy, M., Marcelin, J. R., Marks, G. B., Marr, L., Marrazzo, J., Martina, A., Martin-Moreno, J. M., Mateos, C., Mayxay, M., Mazarati, J. B., Mboup, S., Mcdonald, J., Mcmillan, F., Mechili, E., Medici, A., Davis, S. L. M., Meier, P., Memish, Z. A., Menon, J., Menon, P., Mesiano-Crookston, J., Michie, S., Mikolasevic, I., Milicevic, O., Mishra, A. K., Mohamed, R., Mokdad, A. H., Monroy-Valle, M., Morawska, L., Moschos, S. A., Motawea, K., Mousavi, S. H., Mumtaz, G., Munene, P. K., Munoz Almagro, C., Muriuki, J., Muyingo, S., Naniche, D., Naylor, C. D., Ndembi, N., Nemec, J., Nesteruk, I., Ngaruiya, C., Nguyen, H., Nikolova, D., Nitzan, D., Norheim, O., Noushad, M., Ntoumi, F., Nyborg, G. A., Ochodo, E., Odabasi, Z., Okwen, M. P., Olivia, K., Ong, D. S. Y., Opara, I., Orozco, M., Oshitani, H., Pagel, C., Pai, M., Palsdottir, B., Papatheodoridis, G., Paraskevis, D., Leigh, J. P., Pecoul, B., Peichl, A., Perez-Then, E., Duc, P. P., Philippe, C., Pineda Rojas, A., Pladsen, C., Pozniak, A., Quiroga, R., Qureshi, H., Rampal, S., Ranney, M., Rathe, L., Ratzan, S., Raventos, H., Rees, H., Reis, R., Ricciardi, Walter, Rizk, N., Robalo, M., Robertson, E., Robinson, L., Rokx, C., Ros, T., Rottingen, J. -A., Rubin, M., Ruxrungtam, K., Sadirova, S., Saha, S., Salgado, N., Sanchez, L., Sangaramoorthy, T., Santamaria-Ulloa, C., Santos, R., Sawaf, B., Schneider, M. F., Schooley, R. T., Sener, A., Sepulveda, J., Shah, J., Shibani, M., Shoib, S., Sikazwe, I., Simaitis, A., Gill, A. S., Skhvitaridze, N., Sokolovic, M., Solomon, R., Solorzano, X., Springer, S. A., Srol, J., Staines, A., Stelfox, H. T., Strathdee, S., Sulaiman, L. H., Sutton, B., Svanaes, D., Swed, S., Sypsa, V., Sorensen, K., Tajudeen, R., Tan, A., Tang, J., Tanner, M., Sethi, T., Temmerman, M., Than, K. K., Tinto, H., Tometissi, S. P., Torres, I., Tshering, K. P., Tsiodras, S., Tsofa, B., Vahlne, A., Vargas, J. R., Bernal, I. D. V., Ventura, D., Vilasanjuan, R., Vipond, J., Wamala-Andersson, S., Wargocki, P., West, R., Weyand, A., White, T. M., Wolff, G., Yao, M., Yates, C. A., Yeboah, G., Yee-Sin, L., Yi, S., Teo, Y. -Y., Yong, P., Zamora-Mesia, V., Ovrehus, A., Cascini F. (ORCID:0000-0001-6499-0734), and Ricciardi W. (ORCID:0000-0002-5655-688X)
- Abstract
Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches1, while maintaining proven prevention measures using a vaccines-plus approach2 that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities3 in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.
- Published
- 2022
6. The Normal and Pathological Physiology of Brain Water
- Author
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Go, K. G., Cohadon, F., editor, Dolenc, V. V., editor, Antunes, J. Lobo, editor, Nornes, H., editor, Pickard, J. D., editor, Reulen, H.-J., editor, Strong, A. J., editor, de Tribolet, N., editor, and Tulleken, C. A. F., editor
- Published
- 1997
- Full Text
- View/download PDF
7. Maturation of Cell Damage After Repetitive Hypoxia—Ischemia in the Rat
- Author
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Klein, H. C., Go, K. G., Korf, J., Ito, Umeo, editor, Kirino, Takaaki, editor, Kuroiwa, Toshihiko, editor, and Klatzo, Igor, editor
- Published
- 1997
- Full Text
- View/download PDF
8. Peer Review #1 of "Interrogating COVID-19 vaccine intent in the Philippines with a nationwide open-access online survey (v0.3)"
- Author
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Hartigan-Go, K, additional
- Published
- 2022
- Full Text
- View/download PDF
9. A Study on Peritumoral Brain Edema Around Meningiomas by MRI and Contrast CT
- Author
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Go, K. G., Kamman, R. L., Wilmink, J. T., Mooyaart, E. L., Ito, Umeo, editor, Baethmann, Alexander, editor, Hossmann, Konstantin-A., editor, Kuroiwa, Toshihiko, editor, Marmarou, Anthony, editor, Reulen, Hans-J., editor, and Takakura, Kintomo, editor
- Published
- 1994
- Full Text
- View/download PDF
10. Pathogenesis of Arachnoid Cysts in Relation to the Mechanism of Cerebrospinal Fluid Absorption
- Author
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Go, K. G., Raimondi, Anthony J., editor, Choux, Maurice, editor, and Di Rocco, Concezio, editor
- Published
- 1993
- Full Text
- View/download PDF
11. Magnetite as a Potent Contrast-Enhancing Agent in Magnetic Resonance Imaging to Visualize Blood-Brain Barrier Disruption
- Author
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Bulte, J. W. M., de Jonge, M. W. A., Kamman, R. L., Zuiderveen, F., The, T. H., de Leij, L., Go, K. G., Baethmann, Alexander, editor, Kempski, Oliver, editor, and Schürer, Ludwig, editor
- Published
- 1993
- Full Text
- View/download PDF
12. The Mechanism of Formation of Brain Tumor Cysts
- Author
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Go, K. G., Lohle, P. N. M., Verhagen, I. T. H. J., Teelken, A. W., Blaauw, E. H., Avezaat, C. J. J., editor, van Eijndhoven, J. H. M., editor, Maas, A. I. R., editor, and Tans, J. Th. J., editor
- Published
- 1993
- Full Text
- View/download PDF
13. The pharmaceutical situation in the Philippines
- Author
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Hartigan-Go, K
- Published
- 2001
14. Expression of Annexin and Annexin-mRNA in Rat Brain Under Influence of Steroid Drugs
- Author
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Voermans, P. H., Go, K. G., ter Horst, G. J., Ruiters, M. H. J., Solito, E., Parente, L., Reulen, H.-J., editor, Steiger, H.-J., editor, James, Hector E., editor, Marshall, Lawrence F., editor, Raulen, Hans J., editor, Baethmann, Alexander, editor, Marmarou, Anthony, editor, Ito, Umeo, editor, Hoff, Julian T., editor, Kuroiwa, Toshihiko, editor, and Czernicki, Zbigniew, editor
- Published
- 1997
- Full Text
- View/download PDF
15. The Origin of Lactate in Peritumoral Edema as Measured by Proton-Magnetic Resonance Spectroscopic Imaging
- Author
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Go, K. G., Krikke, A. P., Kamman, R. L., Heesters, M. A. A. M., Reulen, H.-J., editor, Steiger, H.-J., editor, James, Hector E., editor, Marshall, Lawrence F., editor, Raulen, Hans J., editor, Baethmann, Alexander, editor, Marmarou, Anthony, editor, Ito, Umeo, editor, Hoff, Julian T., editor, Kuroiwa, Toshihiko, editor, and Czernicki, Zbigniew, editor
- Published
- 1997
- Full Text
- View/download PDF
16. Effect of Steroids on Brain Lipocortin Immunoreactivity
- Author
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Go, K. G., Zuiderveen, F., De Ley, L., Ter Haar, J. G., Parente, L., Solito, E., Molenaar, W. M., Ito, Umeo, editor, Baethmann, Alexander, editor, Hossmann, Konstantin-A., editor, Kuroiwa, Toshihiko, editor, Marmarou, Anthony, editor, Reulen, Hans-J., editor, and Takakura, Kintomo, editor
- Published
- 1994
- Full Text
- View/download PDF
17. An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME)
- Author
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Bhangu, Aneel, Minaya-Bravo, Ana María, Gallo, Gaetano, Glasbey, James C., Kamarajah, Sivesh, Pinkney, Thomas, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Frasson, Matteo, Glasbey, James, Morton, Dion, Negoi, Ionut, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Luis, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charles, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. 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A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Ã ., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Ã ., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., Su, W. -C., Huang, C. -W., Ma, C. -J., Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Bhangu, A., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., Tan, S., R. Tutino, G. salamone, L. Licari, G. Cocorullo, G. Gulotta, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, and CCA - Cancer Treatment and Quality of Life
- Subjects
Male ,Laparoscopic surgery ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Operative Time ,Anastomosis ,Malignancy ,rectal cancer ,laparoscopic surgery ,TME ,transanal TME ,TaTME ,robotic surgery ,randomized clinical-trial ,short-term outcomes ,laparoscopic-assisted resection ,pathological outcomes ,anastomotic leakage ,initial-experience ,risk ,NO ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Robotic Surgical Procedures ,Humans ,Medicine ,Robotic surgery ,Prospective Studies ,Rectal cancer ,Gastroenterology ,Aged ,Transanal Endoscopic Surgery ,ta3126 ,Medical Audit ,Univariate analysis ,Proctectomy ,Rectal Neoplasms ,business.industry ,Rectum ,Margins of Excision ,Middle Aged ,medicine.disease ,Total mesorectal excision ,Surgery ,Treatment Outcome ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,Rectal cancer surgery ,Female ,Laparoscopy ,030211 gastroenterology & hepatology ,business - Abstract
Introduction: Transanal total mesorectal excision (TaTME) has rapidly emerged as a novel approach for rectal cancer surgery. Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term outcomes of TaTME, open, laparoscopic, and robotic TME internationally. Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients undergoing elective total mesorectal excision (TME) for malignancy between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak. Results: Of 2579 included patients, 76.2% (1966/2579) underwent TME with restorative anastomosis of which 19.9% (312/1966) had a minimally invasive approach (laparoscopic or robotic) which included a transanal component (TaTME). Overall, 9.0% (175/1951, 15 missing outcome data) of patients suffered an anastomotic leak. On univariate analysis both laparoscopic TaTME (OR 1.61, 1.02–2.48, P=0.04) and robotic TaTME (OR 3.05, 1.10–7.34, P=0.02) were associated with a higher risk of anastomotic leak than non-transanal laparoscopic TME. However this association was lost in the mixed-effects model controlling for patient and disease factors (OR 1.23, 0.77–1.97, P=0.39 and OR 2.11, 0.79–5.62, P=0.14 respectively), whilst low rectal anastomosis (OR 2.72, 1.55–4.77, P 
- Published
- 2018
18. Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery
- Author
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Battersby, Nick, Glasbey, James C., Neary, Peter, Negoi, Ionut, Kamarajah, Sivesh, Sgro, Alessandro, Bhangu, Aneel, Pinkney, Thomas, Frasson, Matteo, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Gallo, Gaetano, Glasbey, James, Minaya-Bravo, Ana María, Morton, Dion, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Luis, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charles, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. 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C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez- Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, 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Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Kucukdiler, E, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Ozbalci, G, Ozkan, B, Karabacak, U, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, 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Tutino, G. Salamone, L. Licari, G. Cocorullo, and G. Gulotta
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Male ,Colorectal cancer ,deferral of surgery ,neoadjuvant therapy ,pathology ,radiology ,rectal cancer ,Rectal surgery ,surgical oncology ,Gastroenterology ,0302 clinical medicine ,Prospective Studies ,Prospective cohort study ,Complete response ,Medical Audit ,integumentary system ,Incidence (epidemiology) ,Incidence ,Remission Induction ,Middle Aged ,Magnetic Resonance Imaging ,Europe ,Treatment Outcome ,Response Evaluation Criteria in Solid Tumors ,030220 oncology & carcinogenesis ,Preoperative Period ,030211 gastroenterology & hepatology ,Female ,Adult ,medicine.medical_specialty ,NO ,03 medical and health sciences ,medicine ,Humans ,Intensive care medicine ,Deferral ,Pathological ,Aged ,Neoplasm Staging ,ta3126 ,business.industry ,Rectal Neoplasms ,Reproducibility of Results ,Chemoradiotherapy, Adjuvant ,medicine.disease ,Rectal Neoplasms/diagnostic imaging ,Neoplasm Staging/methods ,business - Abstract
INTRODUCTION: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging.METHODS: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging.RESULTS: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as 'fair' only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively).CONCLUSION: The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials.
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- 2018
19. Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, multi-centre, prospective audit
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Glasbey, J, Blanco-Colino, R, Kelly, M, Singh, B, Bhangu, A, Pinkney, T, Poskus, T, El-Hussuna, A, Battersby, N, Buchs, N, Buskens, C, Chaudri, S, Frasson, M, Gallo, G, Minaya-Bravo, A, Morton, D, Negoi, I, Nepogodiev, D, Pata, F, Sanchez-Guillen, L, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckmann, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, El Nakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Korkolis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Toth, I, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Edden, Y, Halfteck, G, Reissman, P, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, W, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flaaten Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Suleymanov, N, Tarasov, N, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Fernandez-Martinez, D, Otero, J, Solar-Garcia, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, Beltran de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez-Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, L, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Gutierrez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Kucukdiler, E, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Ozbalci, G, Ozkan, B, Karabacak, U, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, J, Williams, G, Raymond, T, Bronder, C, Davies, E, Hawkin, P, Ryska, O, Ayral, K, Beveridge, A, Bhowmik, A, Gill, M, Simpson, R, Schofield, A, Mcardle, K, Parmar, M, Williamson, M, Burton, H, Courtney, E, Grant, C, Saracino, A, Newton, K, Epstein, J, Branagan, G, Bignell, M, Symankewicz, M, Zaman, S, Mankotia, R, Siddiqui, Z, Torrance, A, Artioukh, D, Eggleston, M, Gokul, K, Selwyn, D, Warusavitarne, J, Chandrasinghe, P, Grainger, J, Leo, C, Harris, G, Levy, B, Skull, A, Thaha, M, Garg, A, Patel, H, Ramsanahie, A, Mondragon-Pritchard, M, Cuinas Leon, K, Shukla, A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Smolarek, S, Platt, E, Rossi, B, Tham, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, Glasbey J. C., Blanco-Colino R., Kelly M., Singh B., Bhangu A., Pinkney T., Poskus T., El-Hussuna A., Battersby N. J., Buchs N. C., Buskens C., Chaudri S., Frasson M., Gallo G., Minaya-Bravo A. M., Morton D., Negoi I., Nepogodiev D., Pata F., Sanchez-Guillen L., Zmora O., Perry R., Magill L., Altomare D., Bemelman W., Brown S., Denost Q., Knowles C., Laurberg S., Lefevre J. H., Moeslein G., Vaizey C., Bilali S., Bilali V., Salomon M., Cillo M., Estefania D., Patron Uriburu J., Ruiz H., Farina P., Carballo F., Guckenheimer S., Proud D., Brouwer R., Bui A., Nguyen B., Smart P., Warwick A., Theodore J. 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C., Ghilles E., Vinson-Bonnet B., Germain A., Ayav A., Bresler L., Chevalier R., Didailler R., Rullier E., Tiret E., Chafai N., Parc Y., Sielezneff I., Mege D., Lakkis Z., Barussaud M., Krones C., Bock B., Webler R., Baral J., Lang T., Munch S., Pullig F., Schon M., Hinz S., Becker T., Moller T., Richter F., Schafmayer C., Hardt J., Kienle P., Crescenti F., Ahmad M., Soleiman Y., Papaconstantinou I., Gklavas A., Nastos K., Theodosopoulos T., Vezakis A., Stamou K., Saridaki A., Xynos E., Paraskakis S., Zervakis N., Skroubis G., Amanatidis T., Germanos S., Maroulis I., Papadopoulos G., Dimitriou N., Alexandrou A., Felekouras E., Griniatsos J., Karavokyros I., Papadopoulos A., Chouliaras C., Ioannidis P., Katsounis D., Kefalou E., Katsoulis I. E., Balalis D., Korkolis D. 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P., Blanco Antona F., de Andres Asenjo B., Ferreras Garcia C., Romero de Diego A., Cordoba Diaz de Laspra E., Echazarreta Gallego E., Elia Guedea M., Escola D., Martinez S., Primo Romaguera V., Parreno R., Pastor L., Rosell E., Lozoya Trujillo R., Alos Company R., Ruiz Carmona M. D., Solana Bueno A., Salvans Ruiz S., Alonso Goncalves S., Jimenez-Toscano M., Pascual Damieta M., Pera Roman M., Pellicer-Franco E. M., Garcia-Marin J. A., Mengual-Ballester M., Soria-Aledo V., Valero-Navarro G., Vicente-Ruiz M., Garcia-Zamora C., Gonzalez-Gil A., Montoya-Tabares M. J., Paredes-Quiles M., Die Trill J., Abadia P., Moreno I., Pina J. D., Ramos Rubio D., Escartin J., Blas J. L., Fernando J., Ferrer R., Garcia Egea J., Pros I., Martinez W., Rius J., Socias M., Sabia D., Castellvi Valls J., Gonzalez Santin V., Mompart Garcia S., Viso Pons L., Julia D., Codina-Cazador A., Farres R., Gomez N., Planellas P., Cuadrado M., Camps I., Rufas M., Escoll J., Ferminan A., Muriel P., Sierra E., Alvarez-Laso C., Lora P., Padin H., Garcia-Septiem J., Bustamante C., Jimenez V., Jimenez-Miramon J., Ramos J. L., Gallardo A. B., Benito P., Colao L., Galindo P., Garcia C., Forero-Torres A., Alonso Poza A., Dieguez Fernandez B., Gilsanz Martin C., Hernandez Garcia M., Rojo Lopez J. A., Gil Lopez J. M., Gonzalez Zunzarren M., Martinez Alegre J., Zorrilla Matilla L. P., Navarro-Sanchez A., Alcala Serrano F. J., Lopez-Fernandez J., Montesdeoca Cabrera D., Alvarez-Gallego M., Guevara J., Pascual Miguelanez I., Rubio-Perez I., Gomez Ruiz M., Alonso Martin J., Cagigas Fernandez C., Castillo Diego J., Pando J. 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A., Harris G., Levy B., Skull A., Thaha M., Garg A., Patel H., Ramsanahie A., Mondragon-Pritchard M., Cuinas Leon K., Shukla A., Brewer H., Fitzgerald J., Kho H., Torkington J., Tate S., Wheat J., Smolarek S., Platt E., Rossi B., Tham J. C., Knight J., Richardson J., Tzivanakis A., Gregori M., Ashraf M. A., Atif M., Santos J., Saffaf N., Canning L., Chandratreya N., Bowen M., Graham B., Hamad Y., Kaubrys M., Chaudhry Z. U., Bhan C., Mukhtar H., Oshowo A., Wilson J., Gouvas N., Nicol D., Pandey S., Zilvetti M., Sharma A., Fatayer T., Mothe S., Rahman M., Curtis N., Allison A., Dalton R., Francis N., Ockrim J., Psaras G., Dudarovaska H., Marharint T., Mostovoy E., Voloshin S., Kolesnik O., Makhmudov D., Altinel Y., Iqbal A., Cunningham L., Go K., and Tan S.
- Abstract
Introduction: The optimal bowel preparation strategy to minimise the risk of anastomotic leak is yet to be determined. This study aimed to determine whether oral antibiotics combined with mechanical bowel preparation (MBP+Abx) was associated with a reduced risk of anastomotic leak when compared to mechanical bowel preparation alone (MBP) or no bowel preparation (NBP). Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 Left Sided Colorectal Resection audit was performed. Patients undergoing elective left sided colonic or rectal resection with primary anastomosis between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak. Results: Of 3676 patients across 343 centres in 47 countries, 618 (16.8%) received MBP+ABx, 1945 MBP (52.9%) and 1099 patients NBP (29.9%). Patients undergoing MBP+ABx had the lowest overall rate of anastomotic leak (6.1%, 9.2%, 8.7% respectively) in unadjusted analysis. After case-mix adjustment using a mixed-effects multivariable regression model, MBP+Abx was associated with a lower risk of anastomotic leak (OR 0.52, 0.30–0.92, P = 0.02) but MBP was not (OR 0.92, 0.63–1.36, P = 0.69) compared to NBP. Conclusion: This non-randomised study adds ‘real-world’, contemporaneous, and prospective evidence of the beneficial effects of combined mechanical bowel preparation and oral antibiotics in the prevention of anastomotic leak following left sided colorectal resection across diverse settings. We have also demonstrated limited uptake of this strategy in current international colorectal practice.
- Published
- 2018
20. Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery
- Author
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Battersby, N, Glasbey, J, Neary, P, Negoi, I, Kamarajah, S, Sgro, A, Bhangu, A, Pinkney, T, Frasson, M, El-Hussuna, A, Buchs, N, Buskens, C, Chaudri, S, Gallo, G, Minaya-Bravo, A, Morton, D, Nepogodiev, D, Pata, F, Sanchez-Guillen, L, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckmann, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, El Nakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Korkolis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Toth, I, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Kelly, M, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Edden, Y, Halfteck, G, Reissman, P, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Clerke, C, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Poskus, T, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, W, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flaaten Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Suleymanov, N, Tarasov, N, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Fernandez-Martinez, D, Otero, J, Solar-Garcia, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, Beltran de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez- Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, L, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Gutierrez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Kucukdiler, E, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Ozbalci, G, Ozkan, B, Karabacak, U, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, 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- Abstract
Introduction: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging. Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging. Results: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as ‘fair’ only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively). Conclusion: The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials.
- Published
- 2018
21. Safety of primary anastomosis following emergency left sided colorectal resection: an international, multi-centre prospective audit
- Author
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Sanchez-Guillen, L, Nepogodiev, D, Sivrikoz, E, van Elst, T, Minaya, A, Pata, F, Glasbey, J, Pinkney, T, Bhangu, A, El-Hussuna, A, Buchs, N, Buskens, C, Chaudri, S, Frasson, M, Gallo, G, Morton, D, Negoi, I, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckman, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, Elnakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Kelly, M, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Halfteck, G, Reissman, P, Yair, E, Eden, Y, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Donald, Z, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Jackson, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismiontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Poskus, T, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, Z, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flateh Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Nail, S, Tarasov, N, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Martinez, D, Otero, J, Solar, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, Beltran de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez-Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, J, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Rodriguez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Minaya-Bravo, A, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Ozbalci, G, Ozkan, B, Karabacak, U, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Battersby, N, Broadhurst, J, Mehta, A, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, 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Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, Sanchez-Guillen L., Nepogodiev D., Sivrikoz E., van Elst T., Minaya A., Pata F., Glasbey J., Pinkney T., Bhangu A., El-Hussuna A., Buchs N., Buskens C., Chaudri S., Frasson M., Gallo G., Morton D., Negoi I., Singh B., Zmora O., Perry R., Magill L., Altomare D., Bemelman W., Brown S., Denost Q., Knowles C., Laurberg S., Lefevre J., Moeslein G., Vaizey C., Bilali S., Bilali V., Salomon M., Cillo M., Estefania D., Patron Uriburu J., Ruiz H., Farina P., Carballo F., Guckenheimer S., Proud D., Brouwer R., Bui A., Nguyen B., Smart P., Warwick A., Theodore J., Herbst F., Birsan T., Dauser B., Ghaffari S., Hartig N., Stift A., Argeny S., Unger L., Strouhal R., Heuberger A., Varabei A., Lahodzich N., Makhmudov A., Selniahina L., Feryn T., Leupe T., Maes L., Reynvoet E., Van Langenhove K., Nachtergaele M., Monami B., Francart D., Jehaes C., Markiewicz S., Weerts J., Van Belle K., Bomans B., Cavenaile V., Nijs Y., Vertruyen M., Pletinckx P., Claeys D., Defoort B., Muysoms F., Van Cleven S., Lange C., Vindevoghel K., Wolthuis A., Todorovic M., Dabic S., Kenjic B., Lovric S., Vidovic J., Delibegovic S., Mehmedovic Z., Christiano A., Lombardi B., Marchiori M., Tercioti V., Dardanov D., Petkov P., Simonova L., Yonkov A., Zhivkov E., Maslyankov S., Pavlov V., Sokolov M., Todorov G., Stoyanov V., Batashki I., Iarumov N., Lozev I., Moshev B., Slavchev M., Atanasov B., Belev N., Krstev P., Penkov R., Santak G., Cosic J., Previsic A., Vukusic L., Zukanovic G., Zelic M., Krsul D., Lekic Vitlov V., Mendrila D., Orhalmi J., Dusek T., Maly O., Paral J., Sotona O., Skrovina M., Bencurik V., Machackova M., Kala Z., Farkasova M., Grolich T., Prochazka V., Hoch J., Kocian P., Martinek L., Antos F., Pruchova V., Ceccotti A., Madsboll T., Straarup D., Uth Ovesen A., Christensen P., Bondeven P., Edling P., Elfeki H., Alexandrovich Gameza V., Michelsen Bach S., Zheltiakova I., Krarup P. M., Krogh A., Rolff H. -C., Lykke J., Juvik A. F., Loven H. H. K., Marckman M., Osterkamp J. T. F., Madsen A. H., Worsoe J., Ugianskis A., Kjaer M. D., Youn Cho Lee B., Khalid A., Kristensen M. H., El Sorogy M., Elgeidie A., Elhemaly M., ElNakeeb A., Elrefai M., Shalaby M., Emile S., Omar W., Sakr A., Thabet W., Awny S., Metwally I., Refky B., Shams N., Zuhdy M., Lepisto A., Keranen I., Kivela A., Lehtonen T., Siironen P., Rautio T., Ahonen-Siirtola M., Klintrup K., Paarnio K., Takala H., Hyoty M., Haukijarvi E., Kotaluoto S. -M., Lehto K., Tomminen T., Huhtinen H., Carpelan A., Karvonen J., Rantala A., Varpe P., Cotte E., Francois Y., Glehen O., Passot G., d'Alessandro A., Chouillard E., Etienne J. C., Ghilles E., Vinson-Bonnet B., Germain A., Ayav A., Bresler L., Chevalier R., Didailler R., Rullier E., Tiret E., Chafai N., Parc Y., Sielezneff I., Mege D., Lakkis Z., Barussaud M., Krones C., Bock B., Webler R., Baral J., Lang T., Munch S., Pullig F., Schon M., Hinz S., Becker T., Moller T., Richter F., Schafmayer C., Hardt J., Kienle P., Crescenti F., Ahmad M., Soleiman Y., Papaconstantinou I., Gklavas A., Nastos K., Theodosopoulos T., Vezakis A., Stamou K., Saridaki A., Xynos E., Paraskakis S., Zervakis N., Skroubis G., Amanatidis T., Germanos S., Maroulis I., Papadopoulos G., Dimitriou N., Alexandrou A., Felekouras E., Griniatsos J., Karavokyros I., Papadopoulos A., Chouliaras C., Ioannidis P., Katsounis D., Kefalou E., Katsoulis I., Balalis D., Manatakis D., Tzovaras G., Baloyiannis I., Mamaloudis I., Lazar G., Abraham S., Paszt A., Simonka Z., Zarand A., Baranyai Z., Ferreira G., Harsanyi L., Onody P., Banky B., Burany A., Lakatos M., Marton J., Solymosi A., Besznyak I., Bursics A., Papp G., Saftics G., Svastics I., Valsdottir E., Atladottir J., Jonsson T., Moller P., Sigurdsson H., Gupta S. K., Kaul N., Mohan S., Sharma G., Wani R., Chowdri N., Khan M., Mehraj A., Parray F., Coveney A., Burke J., Deasy J., El-Masry S., McNamara D., Cahill R., Faul E., Mulsow J., Shields C., Kelly M. E., Bass G., Martin S. T., O'Connell R., Ryan E., Connelly T., Ahmad G., Bukhari W., Cooke F., Gold Deutch R., Haim N., Lavy R., Moscovici A., Shussman N., Gefen R., Marom G., Pikarsky A., Weiss D., Avital S., Hermann N., Raguan B., Slavin M., White I., Wasserberg N., Arieli H., Gurevich N., Freund M. R., Dorot S., Halfteck G., Reissman P., Yair E., Eden Y., Pery R., Tulchinsky H., Weizman A., Agresta F., Curinga R., Finotti E., Savino G., Verza L. A., Asteria C. R., Boccia L., Pascariello A., Tamini N., Bugatti A., Gianotti L., Totis M., Vincenti L., Andriola V., Giannini I., Travaglio E., Balestri R., Buccianti P., Roffi N., Rossi E., Urbani L., Mellano A., Cinquegrana A., Lauretta A., Belluco C., Mistrangelo M., Allaix M. E., Arolfo S., Morino M., Testa V., Delrio P., Pace U., Rega D., Scala D., Donald Z., Clerico G., Cornaglia S., Realis Luc A., Trompetto M., Ugolini G., Antonacci N., Fabbri S., Montroni I., Zattoni D., D'Urbano C., Cornelli A., Viti M., Inama M., Bacchion M., Casaril A., Impellizzeri H., Moretto G., Spinelli A., Carvello M., David G., Di Candido F., Sacchi M., Frontali A., Ceriani V., Molteni M., Rosati R., Aleotti F., Elmore U., Lemma M., Vignali A., Scabini S., Casoni Pattacini G., Luzzi A., Romairone E., Marino F., Lorusso D., Pezzolla F., Colombo F., Baldi C., Foschi D., Sampietro G., Sorrentino L., Di Saverio S., Birindelli A., Segalini E., Spacca D., Romano G. M., Belli A., Bianco F., De franciscis S., Falato A., Muratore A., Marsanic P., Grimaldi S., Castaldo N., Ciolli M. G., Picarella P., Porfidia R., Tugnoli G., Bondurri A., Cavallo D., Maffioli A., Pertusati A., Pulighe F., Balestra F., De Nisco C., Podda M., Opocher E., Longhi M., Mariani N. M., Maroni N., Pisani Ceretti A., Galleano R., Aonzo P., Curletti G., Reggiani L., Marconi M., Del Prete L., Oldani M., Pappalardo R., Zaccone l S., Scatizzi M., Baraghini M., Cantafio S., Feroci F., Giani I., Tutino R., Cocorullo G., Gulotta G., Licari L., Salamone G., Sileri P., Saraceno F., La Torre F., Chirletti P., Coletta D., De Toma G., Mingoli A., Papandrea M., De Luca E., Sacco R., Sammarco G., Vescio G., Tonini V., Bianchini S., Cervellera M., Vaccari S., Cracco N., Barugola G., Bertocchi E., Rossini R., Ruffo G., Sartori A., Clemente N., De Luca M., De Luca A., Scaffidi G., Lorenzon L., Balducci G., Bocchetti T., Ferri M., Mercantini P., Jackson P., Bauce S., Benevento A., Bottini C., Crapa P. R., Rubbini M., Anania G., Carcoforo P., Cavallesco G., Feo C., Yamamoto T., Sivins A., Ancans G., Gerkis S., Lunis R., Pcolkins A., Venskutonis D., Bradulskis S., Dainius E., Subocius A., Vencius J., Zeromskas P., Eismiontas V., Nutautiene V., Simcikas D., Tamosiunas A., Svagzdys S., Latkauskas T., Lizdenis P., Saladzinskas Z., Tamelis A., Dulskas A., Kuliavas J., Samalavicius N. E., Poskus T., Jotautas V., Mikalauskas S., Poskus E., Strupas K., Zakaria A., Lah N. N., Wong M., Zain Z., Zakaria Z., Mazlan L., Mohd Azman Z. A., Sagap I., Psaila J., Andrejevic P., Cini C., Ellul S., Pace K., Ahallat M., Hamid M., Hrora A., Majbar M. A., Raiss M., Westerduin E., Tanis P., van der Sluis P. C., Davids P. H., Pronk A., Schiphorst A. H. W., Smakman N., Zimmerman D., Koeter T., Stijns J., van Loon Y. -T., Vermaas M., de Graaf E., Doornebosch P., van Hagen P., van Ruler O., Toorenvliet B., Nonner J., van den Berg I., van Steensel L., Vles W., Melenhorst J., Orsini R., Visschers R., Hoff C., Blom R., Marsman H., Mulder I., Cense H., de Castro S., Demirkiran A., Hunfeld M., van Geloven A., de Groof J., Hendriks E., Leeuwenburg M., van Oorschot N., Wit F., Rupert C., Veldman P., Keijzers M., Konsten J., Den Boer F., Corver M., Boerma E. -J., Koolen L., Martens M., Van Wijck K., Ignjatovic D., Breuer R., Gurpreet B., Oresland T., Tetens Moe T., Nesbakken A., Flateh Backe I., Wik T. -A., Radiya K., Dehli T., Gjessing P., Norderval S., Woll K., Anwer M., Qureshi M. S., Qureshi A. U., Billah M., Jawad M. Y., Raza A., Urooj N., Wang X., Li L., Jajtner D., Gasinski B., Kabiesz W., Walega P., Romaniszyn M., Zawadzki M., Czarnecki R., Obuszko Z., Rzaca M., Sitarska M., Silva P., Duarte A., Goncalves D., Morais M., Rama N., Nobre J., Sales I., Costa Pereira J., Costa S., Costa Pereira C., Insua C., Romero I., Figueiredo N., Cunha J., Domingos H., Vieira P., Cunha M., Americano M., Amorim E., Rachadell J., Carvas J., Armas I., Fernandes P., Pires C., Reis R., Martins R., Dos Santos M., Henriques P., Oliveira O., Duarte M., Ferreira L., Miranda J., Vilela N., Corte Real J., Carlos S., Frois Borges M., Moniz Pereira P., Simoes J., Silva-vaz P., Bettencourt V., Gouveia A., Perez H., Rainho R., Bintintan V., Ciuce C., Dindelegan G., Scurtu R., Seicean R., Cristian D., Burcos T., Grama F., Mandi D. M., Richiteanu G., Miron A., Calu V., Enciu O., Nadragea M., Parvuletu R., Mogoanta S. S., Crafciuc A., Paitici S., Beuran M., Ciubotaru C., Prodan A., Vartic M., Tomulescu V., Copaescu C., Popov D., Sednev A., Klimenko A., Semenov A., Vasilyev S., Pozdnyakov A., Cherdancev D., Mahotin D., Nesytykh A., Samsonyuk V., Pravosudov I., Ivlev D., Karachun A., Lebedev K., Samsonov D., Aiupov R., Feoktistov D., Garipov M., Nail S., Tarasov N., Yanishev A., Abelevich A., Kokobelyan A., Lebedeva M., Luzan R., Rasulov A., Dzhumabaev H., Mamedli Z., Bedzhanyan A., Khazov A., Khanevich M., Khrykov G., Katorkin S., Andreev P., Chernov A., Davidova O., Zhuravlev A., Achkasov S., Shakhmatov D., Shelygin Y., Sushkov O., Vardanyan A., Ilkanich A., Barbashinov N., Darvin V., Onishchenko S., Voronin Y., Krivokapic Z., Barisic G., Dimitrijevic I., Markovic V., Sekulic A., Stanojevic G., Brankovic B., Nestorovic M., Pecic V., Petrovic D., Kostic I., Aleksic A., Dabic D., Maric B., Perunicic V., Radovanovic Z., Djuric M., Lukic D., Radovanovic D., Cuk V., Juloski J., Kenic M., Krdzic I., Ngu J. C., Ng Y. Y., Teo N., Korcek J., Lazorisak A., Rems M., Ramovs Trampus S., Tomazic A., Grosek J., Kosir J., Norcic G., Vigorita V., Caceres N., Casal E., Ruano A., Trostchansky I., Golda T., Galvez Saldana A., Kreisler Moreno E., Lopez Dominguez J., Vila Tura M., Labarga F., Galvez P., Maderuelo V., Suero C., Bargallo J., Cayetano L., Lamas S., Silva M. C., Bernal-Sprekelsen J. C., Gomez R., Jareno S., Rios A., Vercher D., Garcia-Gonzalez J. -M., Cervera-Aldama J., Ramos-Prada J., Santamaria-Olabarrieta M., Borda N., Enrriquez-Navascues J. M., Saralegui Y., Calero-Lillo A., Aznar-Puig S., Lopez-Lara M. A., Munoz-Collado S., Valverde-Sintas J., Menendez P., Leon C., Truan N., Baldonedo R., Martinez D., Otero J., Solar L., Turrado-Rodriguez V., de Lacy Oliver F., Lacy Fortuny A. M., Martin Perez B., Otero Pineiro A. M., Paredes J., Fernandez F., Ladra M. J., Paulos A., Prieto D., Beltran de Heredia J. P., Blanco Antona F., de Andres Asenjo B., Ferreras Garcia C., Romero de Diego A., Cordoba Diaz de Laspra E., Echazarreta Gallego E., Elia Guedea M., Escola D., Martinez S., Primo Romaguera V., Parreno R., Pastor L., Rosell E., Lozoya Trujillo R., Alos Company R., Ruiz Carmona M. D., Solana Bueno A., Salvans Ruiz S., Alonso Goncalves S., Jimenez-Toscano M., Pascual Damieta M., Pera Roman M., Pellicer-Franco E. M., Garcia-Marin J. A., Mengual-Ballester M., Soria-Aledo V., Valero-Navarro G., Vicente-Ruiz M., Garcia-Zamora C., Gonzalez-Gil A., Montoya-Tabares M. J., Paredes-Quiles M., Die Trill J., Abadia P., Moreno I., Pina J. D., Ramos Rubio D., Escartin J., Blas J. L., Fernando J., Ferrer R., Garcia Egea J., Pros I., Martinez W., Rius J., Socias M., Sabia D., Castellvi Valls J., Gonzalez Santin V., Mompart Garcia S., Viso Pons L., Julia D., Codina-Cazador A., Farres R., Gomez N., Planellas P., Cuadrado M., Camps I., Rufas M., Escoll J., Ferminan A., Muriel P., Sierra E., Alvarez-Laso C., Lora P., Padin H., Garcia-Septiem J., Bustamante C., Jimenez V., Jimenez-Miramon J., Ramos J. L., Gallardo A. B., Benito P., Colao L., Galindo P., Garcia C., Forero-Torres A., Alonso Poza A., Dieguez Fernandez B., Gilsanz Martin C., Hernandez Garcia M., Rojo Lopez J. A., Gil Lopez J. M., Gonzalez Zunzarren M., Martinez Alegre J., Zorrilla Matilla J. P., Navarro-Sanchez A., Alcala Serrano F. J., Lopez-Fernandez J., Montesdeoca Cabrera D., Alvarez-Gallego M., Guevara J., Pascual Miguelanez I., Rubio-Perez I., Gomez Ruiz M., Alonso Martin J., Cagigas Fernandez C., Castillo Diego J., Pando J. A., Maristany C., Munoz-Duyos A., Rada-Palomino A., Vargas-Pierola H., Pena Ros E., Benavides Buleje J. A., Munoz Camarena J. M., Parra Banos P. A., Ramirez Faraco M., Arenal J. J., Citores M. A., Marcos J. L., Sanchez J., Tinoco C., Garcia Florez L. J., Arias Pacheco R. D., Minguez Ruiz G., Rodriguez Corral N., Rodriguez Infante A., Carrillo Lopez M. J., Carrasco Prats M. M., Lage Laredo A., Martinez Manzano A., Rodriguez Garcia P., Segura-Sampedro J. J., Alonso-Hernandez N., Fernandez Isart M., Gamundi Cuesta M., Ochogavia Segui A., Ibanez N., Abrisqueta J., Lujan J., Gomez Perez R., Corrales Valero E., Monje Salazar C., Sanchiz Cardenas E., Soler Humanes R., Jimenez-Rodriguez R. M., De la Portilla F., Diaz Pavon J. M., Garcia Cabrera A. M., Reyes Diaz M. L., Espin E., Marinello F., Marti M., Sanchez J. L., Vallribera F., Orts Mico F. J., Ortin Navarro M., Perez Climent M., Serra Diaz C., Millan M., Caro A., Escuder J., Espina B., Feliu F., Climent Aira A., Estevez Diz A., Moreno Asencio M. T., Varela Mato A., Vazquez Bouzan R., Minaya-Bravo A. M., Diez-Alonso M. M., Villeta-Plaza R., Guadalajara H., Alias D., Garcia Olmo D., Pastor C., Valverde I., Sanchez Romero A., Gardea A., Gil Santos M., Nimmersgern T., Serrano Paz P., Romero-Simo M., Blasco-Segura T., Caravaca-Garcia I., Costa-Navarro D., Zarco-Pleguezuelos A., Flor-Lorente B., Garcia-Granero A., Garcia-Granero E., Arencibia B., Alonso J., Febles G., Nogues E. M., Roque C., Segelman J., Nygren J., Nestler G., Abraham-Nordling M., Egenvall M., Myrelid P., Jung B., Loftas P., Lydrup M. -L., Azahr N., Buchwald P., Mangell P., Syk I., Nikberg M., Carlander J., Chabok A., Smedh K., Tiselius C., Haapaniemi S., Benckert A., Adamina M., Freil-Lanter C., Gingert C., Muller P., Schafli J., Regusci L., Brenna M., Fasolini F., Misteli H., Kirchhoff P., Oertli D., Hahnloser D., Clerc D., Hubner M., Ris F., Chevallay M., Morel P., Schiltz B., Wang J. Y., Su W. -C., Huang C. -W., Ma C. -J., Tsai H. -L., Ozbalci G. S., Ozkan B. B., Karabacak U., Bugra D., Agalar F., Baloglu H., Basoglu I., Okkabaz N., Binboga E., Biricik A., Celik A., Yavuz E., Canda A. E., Agalar C., Fuzun M., Sokmen S., Terzi C., Isik A., Karip B., Bilgili A. C., Leventoglu S., Aytac B., Yildiz A., Yuksel O., Sinan H., Hancerliogullari O., Kaymak S., Kozak O., Ozer M. T., Sarici I. S., Akca O., Kalayci M. U., Kara Y., Agcaoglu O., Balik E., Bayram O., Sungurtekin U., Ozgen U., Demirbas S., Ozturk E., Isik O., Yilmazlar T., Colak E., Karagul S., Kinas V., Fearnhead N., Lord I., Stewart P., Zammit M., Arnold S., Battersby N., Broadhurst J., Mehta A., Seretis F., Shabbir J., Jones C., Kynaston J., Vimalachandran D., Blower E., McFaul C., McWhirter D., Pilkington J., Wilson T., Chowdhary M., Stubbs B., Abdalkoddus M., Lai C., Thavanesan N., Yao C., Agarwal T., Dindyal S., Hill R. M. C., Reade S., Slesser A., Paterson H., Balfour A., Boland M., Geraghty A., O'Kelly J., Patel P., Tezas S., Yahia S., Jadhav V., Marimuthu K., Narayanan A., Piramanayagam B., Bradley N., Buchanan F., Paul K., Singh J., Thomson K., Korsgen S., Bedford M., Lee K., Leong K., McArthur D., Malik S., Mohamed I., Cunha P., Pilavas A., Reddy A., Ahmed S., Ahmed A., Voll J., Velchuru V., Lal R., Mirshekar-Syahkal B., Kassai M., Aleem M., Keogh-Bootland S., Sarmah P., Keegan R., Kelkar A., Sen P., Oliveira-Cunha M., Chaudhri S., Fares R., Thomas W. M., Aslam M. I., Boyle K., Hemingway D., Miller A., Norwood M., Gurjar S., Al-Saeedi M., Anandan L., Sudlow A., Zampitis N., Malik K., Bogdan M., Smart C., Iqbal M. R., Bailey S., Lawes D., Omar G., Tamhane R., Evans M., Ather S., Lim J., Nageswaran H., Taylor G., Hunt L., Nicholls J., Shaikh I., Muscara F., O'Brien J., Photi E., Stearns A., Meylemans D., Cunningham C., Hompes R., Tennakoon A., Kumarasinghe N., Rao M., Upanishad I., Smolarek S., Platt E., Rossi B., Tham J. C., Khan J., Ahmad N., Shweejawee Z., Stefan S., Smart N., Daniels I., Gregoir T., Longstaff L., McDermott F., Varcada M., Drami I., Gala T., Moggia E., Ratnatunga K., Harries R., Hayes J., Williams G., Raymond T., Bronder C., Davies E., Hawkin P., Ryska O., Ayral K., Beveridge A., Bhowmik A., Gill M., Simpson R., Schofield A., McArdle K., Parmar M., Williamson M., Burton H., Courtney E., Grant C., Saracino A., Newton K., Epstein J., Branagan G., Bignell M., Symankewicz M., Zaman S., Mankotia R., Siddiqui Z., Torrance A., Artioukh D., Eggleston M., Gokul K., Selwyn D., Warusavitarne J., Chandrasinghe P., Grainger J., Leo C. A., Harris G., Levy B., Skull A., Thaha M., Garg A., Patel H., Ramsanahie A., Mondragon-Pritchard M., Cuinas Leon K., Shukla A., Brewer H., Fitzgerald J., Kho H., Torkington J., Tate S., Wheat J., Knight J., Richardson J., Tzivanakis A., Gregori M., Ashraf M. A., Atif M., Santos J., Saffaf N., Canning L., Chandratreya N., Bowen M., Graham B., Hamad Y., Kaubrys M., Chaudhry Z. U., Bhan C., Mukhtar H., Oshowo A., Wilson J., Gouvas N., Nicol D., Pandey S., Zilvetti M., Sharma A., Fatayer T., Mothe S., Rahman M., Curtis N., Allison A., Dalton R., Francis N., Ockrim J., Psaras G., Dudarovaska H., Marharint T., Mostovoy E., Voloshin S., Kolesnik O., Makhmudov D., Altinel Y., Iqbal A., Cunningham L., Go K., and Tan S.
- Abstract
Introduction: Some evidence suggests that primary anastomosis following left sided colorectal resection in the emergency setting may be safe in selected patients, and confer favourable outcomes to permanent enterostomy. The aim of this study was to compare the major postoperative complication rate in patients undergoing end stoma vs primary anastomosis following emergency left sided colorectal resection. Methods: A pre-planned analysis of the European Society of Coloproctology 2017 audit. Adult patients (> 16 years) who underwent emergency (unplanned, within 24 h of hospital admission) left sided colonic or rectal resection were included. The primary endpoint was the 30-day major complication rate (Clavien-Dindo grade 3 to 5). Results: From 591 patients, 455 (77%) received an end stoma, 103 a primary anastomosis (17%) and 33 primary anastomosis with defunctioning stoma (6%). In multivariable models, anastomosis was associated with a similar major complication rate to end stoma (adjusted odds ratio for end stoma 1.52, 95%CI 0.83–2.79, P = 0.173). Although a defunctioning stoma was not associated with reduced anastomotic leak (12% defunctioned [4/33] vs 13% not defunctioned [13/97], adjusted odds ratio 2.19, 95%CI 0.43–11.02, P = 0.343), it was associated with less severe complications (75% [3/4] with defunctioning stoma, 86.7% anastomosis only [13/15]), a lower mortality rate (0% [0/4] vs 20% [3/15]), and fewer reoperations (50% [2/4] vs 73% [11/15]) when a leak did occur. Conclusions: Primary anastomosis in selected patients appears safe after left sided emergency colorectal resection. A defunctioning stoma might mitigate against risk of subsequent complications
- Published
- 2018
22. The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit
- Author
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A., Harris G., Levy B., Skull A., Thaha M., Garg A., Patel H., Ramsanahie A., Mondragon-Pritchard M., Cuinas Leon K., Shukla A., Brewer H., Fitzgerald J., Kho H., Torkington J., Tate S., Wheat J., Smolarek S., Platt E., Rossi B., Tham J. C., Knight J., Richardson J., Tzivanakis A., Gregori M., Ashraf M. A., Atif M., Santos J., Saffaf N., Canning L., Chandratreya N., Bowen M., Graham B., Hamad Y., Kaubrys M., Chaudhry Z. U., Bhan C., Mukhtar H., Oshowo A., Wilson J., Gouvas N., Nicol D., Pandey S., Zilvetti M., Sharma A., Fatayer T., Mothe S., Rahman M., Curtis N., Allison A., Dalton R., Francis N., Ockrim J., Psaras G., Dudarovaska H., Marharint T., Mostovoy E., Voloshin S., Kolesnik O., Makhmudov D., Altinel Y., Iqbal A., Cunningham L., Go K., Tan S., van der Pool, A, Rawlings, A, Sanchez-Guillen, L, Kuiper, S, Negoi, I, Buchs, N, El-Hussuna, A, Battersby, N, Buskens, C, Chaudri, S, Frasson, M, Gallo, G, Minaya-Bravo, A, Morton, D, Nepogodiev, D, Pata, F, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, C, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Pinkney, T, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, 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B., Karabacak U., Sungurtekin U., Ozgen U., Demirbas S., Ozturk E., Isik O., Yilmazlar T., Colak E., Karagul S., Kinas V., Fearnhead N., Lord I., Stewart P., Zammit M., Arnold S., Broadhurst J., Moran S., Seretis F., Shabbir J., Jones C., Kynaston J., Vimalachandran D., Blower E., McFaul C., McWhirter D., Pilkington J., Wilson T., Chowdhary M., Stubbs B., Abdalkoddus M., Lai C., Thavanesan N., Yao C., Agarwal T., Dindyal S., Hill R. M. C., Reade S., Slesser A., Paterson H., Balfour A., Boland M., Geraghty A., O'Kelly J., Patel P., Tezas S., Yahia S., Jadhav V., Marimuthu K., Narayanan A., Piramanayagam B., Bradley N., Buchanan F., Paul K., Singh J., Thomson K., Korsgen S., Bedford M., Lee K., Leong K., McArthur D., Malik S., Mohamed I., Cunha P., Pilavas A., Reddy A., Ahmed S., Ahmed A., Voll J., Velchuru V., Lal R., Mirshekar-Syahkal B., Kassai M., Aleem M., Keogh-Bootland S., Sarmah P., Keegan R., Kelkar A., Sen P., Oliveira-Cunha M., Chaudhri S., Fares R., Thomas W. M., Aslam M. I., Boyle K., Hemingway D., Miller A., Norwood M., Gurjar S., Al-Saeedi M., Anandan L., Sudlow A., Zampitis N., Malik K., Bogdan M., Smart C., Iqbal M. R., Bailey S., Lawes D., Omar G., Tamhane R., Evans M., Ather S., Lim J., Nageswaran H., Taylor G., Hunt L., Nicholls J., Shaikh I., Muscara F., O'Brien J., Photi E., Stearns A., Meylemans D., Cunningham C., Hompes R., Tennakoon A., Kumarasinghe N., Rao M., Upanishad I., Khan J., Ahmad N., Shweejawee Z., Stefan S., Smart N., Daniels I., Gregoir T., Longstaff L., McDermott F., Varcada M., Drami I., Gala T., Moggia E., Ratnatunga K., Harries R., Hayes J., Williams G., Raymond T., Bronder C., Davies E., Hawkin P., Ryska O., Ayral K., Beveridge A., Bhowmik A., Gill M., Simpson R., Schofield A., McArdle K., Parmar M., Williamson M., Burton H., Courtney E., Grant C., Saracino A., Newton K., Epstein J., Branagan G., Bignell M., Symankewicz M., Zaman S., Mankotia R., Siddiqui Z., Torrance A., Artioukh D., Eggleston M., Gokul K., Selwyn D., Warusavitarne J., Chandrasinghe P., Grainger J., Leo C. A., Harris G., Levy B., Skull A., Thaha M., Garg A., Patel H., Ramsanahie A., Mondragon-Pritchard M., Cuinas Leon K., Shukla A., Brewer H., Fitzgerald J., Kho H., Torkington J., Tate S., Wheat J., Smolarek S., Platt E., Rossi B., Tham J. C., Knight J., Richardson J., Tzivanakis A., Gregori M., Ashraf M. A., Atif M., Santos J., Saffaf N., Canning L., Chandratreya N., Bowen M., Graham B., Hamad Y., Kaubrys M., Chaudhry Z. U., Bhan C., Mukhtar H., Oshowo A., Wilson J., Gouvas N., Nicol D., Pandey S., Zilvetti M., Sharma A., Fatayer T., Mothe S., Rahman M., Curtis N., Allison A., Dalton R., Francis N., Ockrim J., Psaras G., Dudarovaska H., Marharint T., Mostovoy E., Voloshin S., Kolesnik O., Makhmudov D., Altinel Y., Iqbal A., Cunningham L., Go K., and Tan S.
- Abstract
Background: Laparoscopy has now been implemented as a standard of care for elective colonic resection around the world. During the adoption period, studies showed that conversion may be detrimental to patients, with poorer outcomes than both laparoscopic completed or planned open surgery. The primary aim of this study was to determine whether laparoscopic conversion was associated with a higher major complication rate than planned open surgery in contemporary, international practice. Methods: Combined analysis of the European Society of Coloproctology 2017 and 2015 audits. Patients were included if they underwent elective resection of a colonic segment from the caecum to the rectosigmoid junction with primary anastomosis. The primary outcome measure was the 30-day major complication rate, defined as Clavien-Dindo grade III-V. Results: Of 3980 patients, 64% (2561/3980) underwent laparoscopic surgery and a laparoscopic conversion rate of 14% (359/2561). The major complication rate was highest after open surgery (laparoscopic 7.4%, converted 9.7%, open 11.6%, P < 0.001). After case mix adjustment in a multilevel model, only planned open (and not laparoscopic converted) surgery was associated with increased major complications in comparison to laparoscopic surgery (OR 1.64, 1.27–2.11, P < 0.001). Conclusions: Appropriate laparoscopic conversion should not be considered a treatment failure in modern practice. Conversion does not appear to place patients at increased risk of complications vs planned open surgery, supporting broadening of selection criteria for attempted laparoscopy in elective colonic resection
- Published
- 2018
23. An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME)
- Author
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Bhangu, A, Minaya-Bravo, A, Gallo, G, Glasbey, J, Kamarajah, S, Pinkney, T, El-Hussuna, A, Battersby, N, Buchs, N, Buskens, C, Chaudri, S, Frasson, M, Morton, D, Negoi, I, Nepogodiev, D, Pata, F, Sanchez-Guillen, L, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, 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I., Boyle K., Hemingway D., Miller A., Norwood M., Gurjar S., Al-Saeedi M., Anandan L., Sudlow A., Zampitis N., Malik K., Bogdan M., Smart C., Iqbal M. R., Bailey S., Lawes D., Omar G., Tamhane R., Evans M., Ather S., Lim J., Nageswaran H., Taylor G., Hunt L., Nicholls J., Shaikh I., Muscara F., O'Brien J., Photi E., Stearns A., Meylemans D., Cunningham C., Hompes R., Tennakoon A., Kumarasinghe N., Rao M., Upanishad I., Khan J., Ahmad N., Shweejawee Z., Stefan S., Smart N., Daniels I., Gregoir T., Longstaff L., McDermott F., Varcada M., Drami I., Gala T., Moggia E., Ratnatunga K., Harries R., Hayes J., Williams G., Raymond T., Bronder C., Davies E., Hawkin P., Ryska O., Ayral K., Beveridge A., Bhowmik A., Gill M., Simpson R., Schofield A., McArdle K., Parmar M., Williamson M., Burton H., Courtney E., Grant C., Saracino A., Newton K., Epstein J., Branagan G., Bignell M., Symankewicz M., Zaman S., Mankotia R., Siddiqui Z., Torrance A., Artioukh D., Eggleston M., Gokul K., Selwyn D., Warusavitarne J., Chandrasinghe P., Grainger J., Leo C. A., Harris G., Levy B., Skull A., Thaha M., Garg A., Patel H., Ramsanahie A., Mondragon-Pritchard M., Cuinas Leon K., Shukla A., Brewer H., Fitzgerald J., Kho H., Torkington J., Tate S., Wheat J., Smolarek S., Platt E., Rossi B., Tham J. C., Knight J., Richardson J., Tzivanakis A., Gregori M., Ashraf M. A., Atif M., Santos J., Saffaf N., Canning L., Chandratreya N., Bowen M., Graham B., Hamad Y., Kaubrys M., Chaudhry Z. U., Bhan C., Mukhtar H., Oshowo A., Wilson J., Gouvas N., Nicol D., Pandey S., Zilvetti M., Sharma A., Fatayer T., Mothe S., Rahman M., Curtis N., Allison A., Dalton R., Francis N., Ockrim J., Psaras G., Dudarovaska H., Marharint T., Mostovoy E., Voloshin S., Kolesnik O., Makhmudov D., Altinel Y., Iqbal A., Cunningham L., Go K., Tan S., Bhangu, A, Minaya-Bravo, A, Gallo, G, Glasbey, J, Kamarajah, S, Pinkney, T, El-Hussuna, A, Battersby, N, Buchs, N, Buskens, C, Chaudri, S, Frasson, M, Morton, D, Negoi, I, Nepogodiev, D, Pata, F, Sanchez-Guillen, L, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, 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M., Roque C., Segelman J., Nygren J., Nestler G., Abraham-Nordling M., Egenvall M., Myrelid P., Jung B., Loftas P., Lydrup M. -L., Azahr N., Buchwald P., Mangell P., Syk I., Nikberg M., Carlander J., Chabok A., Smedh K., Tiselius C., Haapaniemi S., Benckert A., Adamina M., Freil-Lanter C., Gingert C., Muller P., Schafli J., Regusci L., Brenna M., Fasolini F., Misteli H., Kirchhoff P., Oertli D., Hahnloser D., Clerc D., Hubner M., Ris F., Chevallay M., Morel P., Schiltz B., Wang J. Y., Su W. -C., Huang C. -W., Ma C. -J., Tsai H. -L., Bugra D., Agalar F., Baloglu H., Basoglu I., Okkabaz N., Binboga E., Biricik A., Celik A., Yavuz E., Canda A. E., Agalar C., Fuzun M., Sokmen S., Terzi C., Isik A., Karip B., Bilgili A. C., Leventoglu S., Aytac B., Kucukdiler E., Yildiz A., Yuksel O., Sinan H., Hancerliogullari O., Kaymak S., Kozak O., Ozer M. T., Sarici I. S., Akca O., Kalayci M. U., Kara Y., Agcaoglu O., Balik E., Bayram O., Ozbalci G. S., Ozkan B. B., Karabacak U., Sungurtekin U., Ozgen U., Demirbas S., Ozturk E., Isik O., Yilmazlar T., Colak E., Karagul S., Kinas V., Fearnhead N., Lord I., Stewart P., Zammit M., Arnold S., Broadhurst J., Moran S., Seretis F., Shabbir J., Jones C., Kynaston J., Vimalachandran D., Blower E., McFaul C., McWhirter D., Pilkington J., Wilson T., Chowdhary M., Stubbs B., Abdalkoddus M., Lai C., Thavanesan N., Yao C., Agarwal T., Dindyal S., Hill R. M. C., Reade S., Slesser A., Paterson H., Balfour A., Boland M., Geraghty A., O'Kelly J., Patel P., Tezas S., Yahia S., Jadhav V., Marimuthu K., Narayanan A., Piramanayagam B., Bradley N., Buchanan F., Paul K., Singh J., Thomson K., Korsgen S., Bedford M., Lee K., Leong K., McArthur D., Malik S., Mohamed I., Cunha P., Pilavas A., Reddy A., Ahmed S., Ahmed A., Voll J., Velchuru V., Lal R., Mirshekar-Syahkal B., Kassai M., Aleem M., Keogh-Bootland S., Sarmah P., Keegan R., Kelkar A., Sen P., Oliveira-Cunha M., Chaudhri S., Fares R., Thomas W. M., Aslam M. I., Boyle K., Hemingway D., Miller A., Norwood M., Gurjar S., Al-Saeedi M., Anandan L., Sudlow A., Zampitis N., Malik K., Bogdan M., Smart C., Iqbal M. R., Bailey S., Lawes D., Omar G., Tamhane R., Evans M., Ather S., Lim J., Nageswaran H., Taylor G., Hunt L., Nicholls J., Shaikh I., Muscara F., O'Brien J., Photi E., Stearns A., Meylemans D., Cunningham C., Hompes R., Tennakoon A., Kumarasinghe N., Rao M., Upanishad I., Khan J., Ahmad N., Shweejawee Z., Stefan S., Smart N., Daniels I., Gregoir T., Longstaff L., McDermott F., Varcada M., Drami I., Gala T., Moggia E., Ratnatunga K., Harries R., Hayes J., Williams G., Raymond T., Bronder C., Davies E., Hawkin P., Ryska O., Ayral K., Beveridge A., Bhowmik A., Gill M., Simpson R., Schofield A., McArdle K., Parmar M., Williamson M., Burton H., Courtney E., Grant C., Saracino A., Newton K., Epstein J., Branagan G., Bignell M., Symankewicz M., Zaman S., Mankotia R., Siddiqui Z., Torrance A., Artioukh D., Eggleston M., Gokul K., Selwyn D., Warusavitarne J., Chandrasinghe P., Grainger J., Leo C. A., Harris G., Levy B., Skull A., Thaha M., Garg A., Patel H., Ramsanahie A., Mondragon-Pritchard M., Cuinas Leon K., Shukla A., Brewer H., Fitzgerald J., Kho H., Torkington J., Tate S., Wheat J., Smolarek S., Platt E., Rossi B., Tham J. C., Knight J., Richardson J., Tzivanakis A., Gregori M., Ashraf M. A., Atif M., Santos J., Saffaf N., Canning L., Chandratreya N., Bowen M., Graham B., Hamad Y., Kaubrys M., Chaudhry Z. U., Bhan C., Mukhtar H., Oshowo A., Wilson J., Gouvas N., Nicol D., Pandey S., Zilvetti M., Sharma A., Fatayer T., Mothe S., Rahman M., Curtis N., Allison A., Dalton R., Francis N., Ockrim J., Psaras G., Dudarovaska H., Marharint T., Mostovoy E., Voloshin S., Kolesnik O., Makhmudov D., Altinel Y., Iqbal A., Cunningham L., Go K., and Tan S.
- Abstract
Introduction: Transanal total mesorectal excision (TaTME) has rapidly emerged as a novel approach for rectal cancer surgery. Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term outcomes of TaTME, open, laparoscopic, and robotic TME internationally. Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients undergoing elective total mesorectal excision (TME) for malignancy between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak. Results: Of 2579 included patients, 76.2% (1966/2579) underwent TME with restorative anastomosis of which 19.9% (312/1966) had a minimally invasive approach (laparoscopic or robotic) which included a transanal component (TaTME). Overall, 9.0% (175/1951, 15 missing outcome data) of patients suffered an anastomotic leak. On univariate analysis both laparoscopic TaTME (OR 1.61, 1.02–2.48, P = 0.04) and robotic TaTME (OR 3.05, 1.10–7.34, P = 0.02) were associated with a higher risk of anastomotic leak than non-transanal laparoscopic TME. However this association was lost in the mixed-effects model controlling for patient and disease factors (OR 1.23, 0.77–1.97, P = 0.39 and OR 2.11, 0.79–5.62, P = 0.14 respectively), whilst low rectal anastomosis (OR 2.72, 1.55–4.77, P < 0.001) and male gender (OR 2.29, 1.52–3.44, P < 0.001) remained strongly associated. The overall positive circumferential margin resection rate was 4.0%, which varied between operative approaches: laparoscopic 3.2%, transanal 3.8%, open 4.7%, robotic 1%. Conclusion: This contemporaneous international snapshot shows that uptake of the TaTME approach is widespread and is associated with surgically and pathologically acceptable results.
- Published
- 2018
24. Passage of DMP Across a Disrupted BBB in the Context of Antibody-mediated MR Imaging of Brain Metastases
- Author
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Bulte, J. W. M., de Jonge, M. W. A., de Leij, L., The, T. H., Kamman, R. L., Blaauw, B., Zuiderveen, F., Go, K. G., Reulen, Hans-J., editor, Baethmann, Alexander, editor, Fenstermacher, Joseph, editor, Marmarou, Anthony, editor, and Spatz, Maria, editor
- Published
- 1990
- Full Text
- View/download PDF
25. Abstracts
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Derlon J. M., Petit-taboué M. C., Dauphin F., Courtheoux P., Chapon F., Creissard P., Darcel F., Houtteville J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go K. G., Kamman R. L., Mooyaart E. L., Heesters M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn U., Fröhlich T., Becker G., Krone A., Schlief R., Schürmann J., Jachimczak P., Hofmann E., Roggendorf W., Roosen K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank G. S., Patterson J., Hadley D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge, Ernestus, R. -I., Bockhorst, K., Eis, M., Els, T., Hoehn-Berlage, M., Gliese, M., Fründ, R., Geissler, A., Woertgen, C., Holzschuh, M., Goldman, Serge, Levivier, M., Pirotte, B., Brucher, J. 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D., Colombo, Bruno M., DiDonato, Stefano, Finocchiaro, Gaetano, Hebeda, K. M., Sterenborg, H. J. C. M., Saarnak, A. E., Wolbers, J. G., van Gemert, M. J. C., Kaaijk P., Troost D., Leenstra S., Das P. K., Bosch D. A., Kostron H., Hochleitner B. W., Obwegeser A., Ortler M., Seiwald M., Vooys, W., Krouwer, H. G. J., de Gast, G. C., Marx, J. J. M., Osman Farah J., Lunardi P., Puzzilli F., Menovsky, T., Beek, J. F., Wolbers, J. G., van Gemert, M. J. C., Naujocks, G., Wiestler, O. D., Schirrmacher, V., Schramm, J., Schmitz, A., Eis-Hübinger, A. M., Piepmeier, p. h., Pedersen, Patricia, Greer, Charles, Quigley, Matthew R., Shih, Tommy, Elrifal, Amr, Rothfus, William, Maroon, Joseph C., Rohertson, L., Rampling, R., Whoteley, T. L., Piumb, J. A., Kerr, D. J., Falina, P. A., Crossan, I. M., Roosen N., Rock J. P., Feng J., Zeng H., Ho K. L., Fenstermacher J. D., Rosenblum M. L., Ruchoux, M. M., Vincent, S., Jonca, F., Plouet, J., Lecomte, M., Samid, D., Thibault, A., Ram, Z., Oldfield, E. 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J., Steward M. S., Campbell S. M., Roy S., Hilkens, P. H. E., Verweij, J., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Wondrusch E., Zifko U., Drlicek M., Liszka U., Grisold W., Zifko U., Fazeny B., Dittrich Ch., Wondrusch E., Grisold W., Verschuuren, Jan J., Meneses, Patricio I., Rosenfeld, Myrna R., Kaplitt, Michael G., Posner, Jerome B., Dalmau, Josep, Sillevis Smitt P. A. E., Manley G., Posner J. B., Cavaletti, G., Bogliun, G., Margorati, L., Bianchi, G., Drlicek, M., Liska, U., Casati, B., Kolig, C., Grisold, H., Graus, F., Reñe, R., Uchuya, M., Valldeoriola, F., Delattre, J. Y., Benedetti de Cosentiro C., Ortale D., Martinez R., Lambre J., Cagnolati S., Vinai C., Salmaggi A., Nemni R., Silvani A., Forno M. G., Luksch R., Confalonieri P., Boiardi A., Nitschke M., Scholz J., Vieregge P., Kömpf D., Hochberg F. H., Pfeiffer, G., Netzer, J., Hansen, Ch., Eggers, Ch., Hagel Ch., Kunze, K., Verschuuren, Jan J., Rosenblum, Marc K., Lieberman, Frank S., Posner, Jerome B., and Dalmau, Josep
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26. Erratum to: Occult pneumothorax in blunt trauma: is there a need for tube thoracostomy?
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Zhang, M., Goh, M. H., Leow, J. J., Go, K. T. S., and Teo, L. T.
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27. Proliferation and Apoptosis in Long-term Surviving Low Grade Gliomas in Relation to Radiotherapy
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Heesters, Mart A.A.M., Koudstaal, Jan, Gwan Go, K., and Molenaar, Willemina M.
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28. On the pathogenesis of brain tumour cysts: a volumetric study of tumour, oedema and cyst
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Lohle, P. N. M., van Mameren, H., Zwinderman, K. H., Teepen, H. L. J. M., Go, K. G., and Wilmink, J. T.
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29. Pseudotumour Cerebri: Incidence, Management and Prevention
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Go, K. Gwan
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30. Retrofit and replacement of Dumbarton railroad bridges, California, USA
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Treyger, S, primary, Hill, S, additional, Susanto, B, additional, Go, K, additional, Yang, W, additional, and Jones, M, additional
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31. Evaluation of Dissemination Studies with FDG Whole-Body Positron Emission Tomography in Patients with Suspected Metastatic Tumours of Brain and Spine
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Go, K. G., Pruim, J., Que, T. H., Vaalburg, W., and Haaxma-Reiche, H.
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32. Cystic lesions accompanying extra-axial tumours
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Lohle, P. N. M., Wurzer, H. A. L., Seelen, P. J., Kingma, L. M., and Go, K. G.
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33. Neck Location on the Outer Convexity is a Predictor of Incomplete Occlusion in Treatment with the Pipeline Embolization Device: Clinical and Angiographic Outcomes
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Sunohara, T., primary, Imamura, H., additional, Goto, M., additional, Fukumitsu, R., additional, Matsumoto, S., additional, Fukui, N., additional, Oomura, Y., additional, Akiyama, T., additional, Fukuda, T., additional, Go, K., additional, Kajiura, S., additional, Shigeyasu, M., additional, Asakura, K., additional, Horii, R., additional, Sakai, C., additional, and Sakai, N., additional
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34. The Pathogenesis of Cysts Accompanying Intra-axial Primary and Metastatic Tumors of the Central Nervous System
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Lohle, Paul N.M., Wurzer, Hans A.L., Seelen, Petrus J., Kingma, Lucas M., and Gwan Go, K.
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35. MAPPING POVERTY IN THE PHILIPPINES USING MACHINE LEARNING, SATELLITE IMAGERY, AND CROWD-SOURCED GEOSPATIAL INFORMATION
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Tingzon, I., primary, Orden, A., additional, Go, K. T., additional, Sy, S., additional, Sekara, V., additional, Weber, I., additional, Fatehkia, M., additional, García-Herranz, M., additional, and Kim, D., additional
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36. Vigilance & Wake-A-Thons: a novel sleep health communication concept proposed by vancouver summer sleep school students
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Xiao, K., primary, Mavani, S., additional, Go, K., additional, Boldut, R., additional, Xu, K., additional, Cho, J., additional, Beyzaei, N., additional, Tse, E., additional, Khalili, R., additional, Chan, M., additional, Beaulieu, E., additional, Richmond, S.A., additional, Babul, S., additional, Pike, I., additional, Cox, L.V., additional, Klösch, G., additional, and Ipsiroglu, O.S., additional
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37. The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit
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van der Pool, Anne, Rawlings, Alexandra, Sánchez-Guillén, Luis, Kuiper, Sara, Negoi, Ionut, Buchs, Nicolas, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Frasson, Matteo, Gallo, Gaetano, Minaya-Bravo, Ana María, Morton, Dion, Nepogodiev, Dmitri, Pata, Francesco, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Christianne Buskens Quentin, Knowles, Charles, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., El-Hussuna, A., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. 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P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, 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A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Smolarek, S, Platt, E, Rossi, B, Tham, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, R. Tutino, G. Salamone, L. Licari, G. Cocorullo, G. Gulotta, AGEM - Digestive immunity, Surgery, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, RS: NUTRIM - R2 - Liver and digestive health, and 2017 and 2015 European Society of Coloproctology (ESCP) collaborating, Group
- Subjects
Laparoscopic surgery ,Male ,Colorectal cancer ,medicine.medical_treatment ,surgery ,0302 clinical medicine ,Postoperative Complications ,Medicine ,Major complication ,Prospective Studies ,Laparoscopy ,SHORT-TERM OUTCOMES ,Colectomy ,Medical Audit ,medicine.diagnostic_test ,Prospective audit ,Gastroenterology ,Middle Aged ,laparoscopic surgery ,Conversion to Open Surgery ,Colon cancer ,Treatment Outcome ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,Colonic surgery ,Adult ,medicine.medical_specialty ,CLINICAL-TRIAL ,NO ,OPEN COLECTOMY ,03 medical and health sciences ,COLORECTAL SURGERY ,Case mix index ,gastrointestinal surgery ,Humans ,rectal cancer ,RECTAL-CANCER ,Aged ,ta3126 ,business.industry ,Elective resection ,medicine.disease ,RANDOMIZED-TRIAL ,OPEN RESECTION ,Surgery ,business - Abstract
BACKGROUND: Laparoscopy has now been implemented as a standard of care for elective colonic resection around the world. During the adoption period, studies showed that conversion may be detrimental to patients, with poorer outcomes than both laparoscopic completed or planned open surgery. The primary aim of this study was to determine whether laparoscopic conversion was associated with a higher major complication rate than planned open surgery in contemporary, international practice.METHODS: Combined analysis of the European Society of Coloproctology 2017 and 2015 audits. Patients were included if they underwent elective resection of a colonic segment from the caecum to the rectosigmoid junction with primary anastomosis. The primary outcome measure was the 30-day major complication rate, defined as Clavien-Dindo grade III-V.RESULTS: Of 3980 patients, 64% (2561/3980) underwent laparoscopic surgery and a laparoscopic conversion rate of 14% (359/2561). The major complication rate was highest after open surgery (laparoscopic 7.4%, converted 9.7%, open 11.6%, P < 0.001). After case mix adjustment in a multilevel model, only planned open (and not laparoscopic converted) surgery was associated with increased major complications in comparison to laparoscopic surgery (OR 1.64, 1.27-2.11, P < 0.001).CONCLUSIONS: Appropriate laparoscopic conversion should not be considered a treatment failure in modern practice. Conversion does not appear to place patients at increased risk of complications vs planned open surgery, supporting broadening of selection criteria for attempted laparoscopy in elective colonic resection.
- Published
- 2018
38. 11C-tyrosine position emission tomography and 1H magnetic resonance spectroscopy of the response of brain gliomas to radiotherapy
- Author
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Heesters, M. A. A. M., Go, K. G., Kamman, R. L., Mooyaart, E. L., Meertens, H., Paans, A. M. J., and Pruim, J.
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- 1998
- Full Text
- View/download PDF
39. A new vicinal-dioxime and its mono and trinuclear complexes containing the monoazatetraoxa macrocyclic moiety
- Author
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Karabo¨cek, Serdar, Bilgin, Ahmet, and Go¨k, Yasar
- Published
- 1997
- Full Text
- View/download PDF
40. Progesterone receptors in arachnoid cysts: An immunocytochemical study in 2 cases
- Author
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Go, K. G., Blankenstein, M. A., Vroom, T. M., Blaauw, E. H., Dijk, F., Hollema, H., and Verhagen, A.
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- 1997
- Full Text
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41. Glioblastoma multiforme in four siblings: A cytogenetic and molecular genetic study
- Author
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Dirven, Clemens M. F., Tuerlings, Joep, Molenaar, Willemina M., Go, K. Gwan, and Louis, David N.
- Published
- 1995
- Full Text
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42. Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography
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Go, K. G., Kamman, R. L., Mooyaart, E. L., Heesters, M. A. A. M., Pruim, J., Vaalburg, W., and Paans, A. M. J.
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- 1995
- Full Text
- View/download PDF
43. On the principles underlying the diagnosis of brain tumours — A survey article
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Go, K. G., Kamman, R. L., Pruim, J., Hew, J. M., Vaalburg, W., Paans, A. M. J., Mooyaart, E. L., Heesters, M. A. A. M., and Lopes da Silva, F. H.
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- 1995
- Full Text
- View/download PDF
44. Intracerebral and subcutaneous xenografts of human SCLC in the nude rat: comparison of monoclonal antibody localization and tumor infiltrating lymphocytes
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Bulte, Jeff W. M., Go, K. Gwan, Zuiderveen, Fred, The, T. Hauw, and de Leij, Lou
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- 1993
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- View/download PDF
45. A study on peritumoural brain oedema around meningiomas by CT and MRI scanning
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Go, K. G., Kamman, R. L., Wilmink, J. T., and Mooyaart, E. L.
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- 1993
- Full Text
- View/download PDF
46. Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy
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Heesters, M. A. A. M., Kamman, R. L., Mooyaart, E. L., and Go, K. G.
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- 1993
- Full Text
- View/download PDF
47. Evaluation of results of temporal bone resection
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Go, K. G., Annyas, A. A., Vermey, A., Robinson, P. H., Belopavlovic, M., and Mehta, D. M.
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- 1991
- Full Text
- View/download PDF
48. Pseudotumour Cerebri: Incidence, Management and Prevention
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Gwan Go, K.
- Published
- 2000
49. Comparative Studies on the Physicochemical Properties of Tisseel and a Newly Developed Fibrin Sealant
- Author
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Sawada, K., primary, Yoshimura, H., additional, Yamamoto, H., additional, Yago, H., additional, Takeuchi, S., additional, Matsumoto, K., additional, Go, K., additional, and Suehiro, S., additional
- Published
- 1994
- Full Text
- View/download PDF
50. FABRICATION OF TENSILE STRAIN APPLYING STRUCTURE TO SUSPENDED GRAPHENE FOR NANOMECHANICAL RESONATOR WITH HIGH FQ PRODUCT
- Author
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Uesaka, J., primary, Go, K., additional, Kidane, S., additional, Sawada, K., additional, and Takahashi, K., additional
- Published
- 2019
- Full Text
- View/download PDF
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