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7 results on '"Gnoatto, S. C. B."'

2. Triterpenoids from Brazilian Ilex Species and Their in Vitro Antitrypanosomal Activity

Author

Taketa, A. T. C., Gnoatto, S. C. B., Gosmann, G., Pires, V. S., Schenkel, E. P., and Guillaume, D.

Abstract

From the leaves of Ilex affinis and Ilex buxifolia, two adulterant species of “erva maté” (Ilex paraguariensis), three new triterpenoid glycosides were isolated. Affinoside 1 (3β-O-{β-d-glucopyranosyl-(1→3)-[2-O-acetyl-(1→2]}-α-l-arabinopyranosyl pomolic acid 28-O-β-d-glucopyranosyl ester, 1) was isolated from I. affinis, while buxifolioside I (28-O-β-d-glucopyranosyl ester of (20S)-3α,19α-dihydroxyurs-12-ene-23,28-dioic acid, 7) and buxifolioside II (28-O-β-d-glucopyranosyl ester of (20S)-3β,19α-dihydroxyurs-12-en-24,28-dioic acid, 8) were isolated from I. buxifolia. Along with these new compounds, ilexoside II (2), ursolic acid (3), 28-nor-ursolic acid (4), 3β-O-acetylursolic acid (5), and uvaol (6) were also isolated. The observed results confirm the structural specificity of the I. paraguariensis triterpenoids and reinforce a previous proposal to detect maté adulteration by triterpenoid analysis. In addition, the in vitro antitrypanosomal activity of some Ilex triterpenoids is also reported.

Published
2004

7. Natural and Semi synthetic Antimalarial Compounds: Emphasis on the Terpene Class.

Author

Silva GN, Rezende LC, Emery FS, Gosmann G, and Gnoatto SC

Subjects
Animals, Antimalarials chemistry, Antimalarials toxicity, Artemisinins chemical synthesis, Artemisinins chemistry, Artemisinins pharmacology, Biological Products isolation & purification, Biological Products toxicity, Cell Survival drug effects, Humans, Plants, Medicinal chemistry, Plants, Medicinal metabolism, Plasmodium falciparum drug effects, Structure-Activity Relationship, Terpenes chemical synthesis, Terpenes toxicity, Antimalarials chemical synthesis, Biological Products chemistry, Terpenes chemistry
Abstract

Malaria is one of the most important tropical diseases since more than 40% of the world population is at risk. This disease is endemic to more than 100 nations and remains one of the main leading causes of death in children less than five years of age worldwide. Natural product-derived compounds have played a major role in drug discovery, often as prototypes to obtain more active semi synthetic derivatives. Antimalarial pharmacotherapy is a significant example of plant-derived medicines, such as quinine and artemisinin. This review highlights studies on terpenes and their semi synthetic derivatives from natural sources with antimalarial activity reported in the literature during eleven years (2002-2013). A total of 114 compounds are found among terpenes and their semi synthetic derivatives. Cytotoxicity of the compounds is also found in this review. Furthermore, the physicochemical properties of the terpenes addressed are discussed based on seven well established descriptors, which provide a useful source for the elaboration of a terpene library of antimalarial compounds.

Published
2015
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