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3. High prevalence of malnutrition in an internal medicine department: results from the AMIDO study.

Author

Gnerre, Paola, Lingua, Stefania, Farotto, Marianna, Mazzucco, Riccardo, Crivellari, Stefania, Bertolina, Carlotta, Giacchero, Fabio, Cerutti, Paola, Seksich, Elena, Bertolotti, Marinella, and Maconi, Antonio

Subjects
*HEART failure, *DEMENTIA patients, *ODDS ratio, *HOSPITAL patients, *COMMUNICABLE diseases
Abstract

The prevalence of malnutrition in patients is very high in Europe (>70%). An Italian FADOI-SINPE survey revealed that malnutrition is an underestimated problem by internists. The AMIDO study examines malnutrition in Acqui Terme Hospital (Alessandria, Italy) Internal Medicine Department patients. Patients were screened for malnutrition using the Malnutrition Universal Screening Tool (MUST) upon admission. 268 patients (49.63% male) were enrolled, with a median age of 83 years. At admission, the prevalence of malnutrition risk was 48.88%. The proportion of patients who came from home resulted to have a slight decreasing trend among the three subgroups according to MUST (84.67%, 82.76%, and 73.53% in increasing order of MUST score respectively), but was not statistically significant (P=0.10). Dementia [odds ratio (OR): 6.36; 95% confidence interval (CI): 2.52-18.63], heart failure (OR: 2.45; 95% CI: 1.33-4.57), neoplasm (OR: 2.24; 95% CI: 1.08-4.77) and infectious diseases (OR: 2.27; 95% CI: 1.226-4.274) increase malnutrition odds. Increasing attention to malnutrition risk is crucial for patients with dementia, neoplasm, heart failure, and infectious diseases, which raise malnutrition risk probability. [ABSTRACT FROM AUTHOR]

Published
2024
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5. The use of risk scores for thromboprophylaxis in medically ill patients – Rationale and Design of the RICO trial

Author

Dentali, Francesco, additional, Campanini, Mauro, additional, Bonaventura, Aldo, additional, Fontanella, Luca, additional, Zuretti, Francesca, additional, Tavecchia, Luca, additional, Mumoli, Nicola, additional, Gnerre, Paola, additional, Ventrella, Francesco, additional, Giustozzi, Michela, additional, Valerio, Antonella, additional, and Fontanella, Andrea, additional

Published
2023
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7. Medication review and deprescribing in different healthcare settings: a position statement from an Italian scientific consortium.

Author

Carollo, Massimo, Boccardi, Virginia, Crisafulli, Salvatore, Conti, Valeria, Gnerre, Paola, Miozzo, Simonetta, Omodeo Salè, Emanuela, Pieraccini, Fabio, Zamboni, Mauro, Marengoni, Alessandra, Onder, Graziano, Trifirò, Gianluca, Antonioni, Raffaella, Selleri, Margherita, Vitturi, Giacomo, Filippelli, Amelia, Corrao, Salvatore, Medea, Gerardo, Nobili, Alessandro, and Pasina, Luca

Abstract

Recent medical advancements have increased life expectancy, leading to a surge in patients affected by multiple chronic diseases and consequent polypharmacy, especially among older adults. This scenario increases the risk of drug interactions and adverse drug reactions, highlighting the need for medication review and deprescribing to reduce inappropriate medications and optimize therapeutic regimens, with the ultimate goal to improving patients’ health and quality of life. This position statement from the Italian Scientific Consortium on medication review and deprescribing aims to describe key elements, strategies, tools, timing, and healthcare professionals to be involved, for the implementation of medication review and deprescribing in different healthcare settings (i.e., primary care, hospital, long-term care facilities, and palliative care). Challenges and potential solutions for the implementation of medication review and deprescribing are also discussed. [ABSTRACT FROM AUTHOR]

Published
2024
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8. COVID-19 after 2 Years from Hospital Discharge: A Pulmonary Function and Chest Computed Tomography Follow-Up Study.

Author

Mennella, Simone, Alicino, Cristiano, Anselmo, Marco, Carrega, Giuliana, Ficarra, Gianluca, Garra, Luca, Gastaldo, Alessandro, Gnerre, Paola, Lillo, Flavia, Tassara, Rodolfo, Terrile, Anna, and Milanese, Manlio

Subjects
PATIENT aftercare, COVID-19, CHEST X rays, SCIENTIFIC observation, POST-acute COVID-19 syndrome, LUNGS, SEVERITY of illness index, PULMONARY function tests, DESCRIPTIVE statistics, COMPUTED tomography, SPIROMETRY, DISCHARGE planning, LONGITUDINAL method
Abstract

Introduction: Serial follow-up with pulmonary function testing (PFT) and chest computed tomography (CT) after severe COVID-19 are recommended. As a result, many longitudinal studies have been published on COVID-19 of different grade of severity up to 1-year follow-up. Therefore, we aimed at a long-term observational study throughout 2 years after severe COVID-19. Methods: Severe COVID-19 patients were consecutively recruited after hospital discharge between March and June 2020 and prospectively followed up for 24 months, with mMRC dyspnea scale and PFT at 6, 12, and 24 months. Chest CT was performed when clinically indicated. Results: One hundred one patients enrolled completed the observational study. At 24 months, those with reduced total lung capacity (TLC) were 16%, associated with fibrotic ground glass opacity (GGO) and mMRC score >1, respectively, in 75% and 69% of them. At 24 months, those with a reduced diffusing capacity of the lung for CO were 41%, associated with fibrotic GGO and mMRC score >1, respectively, in 53% and 22% of them. Conclusion: Two years after hospitalization for severe COVID-19, a non-negligible number of patients still suffer from "long COVID" due to respiratory damage. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Italian good practice recommendations on management of persons with Long-COVID

Author

Giuliano, Marina, primary, Tiple, Dorina, additional, Agostoni, Piergiuseppe, additional, Armocida, Benedetta, additional, Biardi, Ludovico, additional, Bonfigli, Anna Rita, additional, Campana, Andrea, additional, Ciardi, Maria, additional, Di Marco, Fabiano, additional, Floridia, Marco, additional, Gnerre, Paola, additional, Grassi, Tiziana, additional, Grattagliano, Ignazio, additional, Kruger, Paola, additional, Leonardi, Matilde, additional, Liguori, Rocco, additional, Pagani, Elisabetta, additional, Perger, Elisa, additional, Pricci, Flavia, additional, Ruggeri, Marinella, additional, Silenzi, Andrea, additional, Spannella, Francesco, additional, Tascini, Carlo, additional, Teté, Giulia, additional, Tosato, Matteo, additional, Vecchi, Simona, additional, Villa, Marika, additional, and Onder, Graziano, additional

Published
2023
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12. Outcomes of patients with COVID-19 hospitalized during the fourth pandemic wave in relation to their clinical features and vaccination status

Author

Crivellari, Stefania, primary, Pasquali, Mercedes, additional, Aiosa, Giuseppe, additional, Daniele, Antonio, additional, Bertolotti, Marinella, additional, Salerno, Christian, additional, Pacileo, Guglielmo, additional, Marchisio, Sara, additional, Maconi, Antonio, additional, and Gnerre, Paola, additional

Published
2023
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13. Italian intersociety consensus on prevention, diagnosis, and treatment of delirium in hospitalized older persons

Author

Bellelli, Giuseppe, Morandi, Alessandro, Trabucchi, Marco, Caironi, Guido, Coen, Daniele, Fraticelli, Carlo, Paolillo, Ciro, Prevaldi, Carolina, Riccardi, Angela, Cervellin, Gianfranco, Carabellese, Corrado, Putignano, Salvatore, Maggi, Stefania, Cherubini, Antonio, Gnerre, Paola, Fontanella, Andrea, Latronico, Nicola, Tommasino, Concezione, Corcione, Antonio, Ricevuti, Giovanni, Ferrara, Nicola, De Filippi, Francesco, Ferrari, Alberto, Guarino, Mario, Ruggieri, Maria Pia, Modesti, Pietro Amedeo, Locatelli, Carlo, Hrelia, Patrizia, Toscano, Marco Otto, Bondi, Emi, Tarasconi, Antonio, Ansaloni, Luca, and Perticone, Francesco

Published
2017
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14. Esiti dei pazienti COVID-19 positivi ricoverati durante la quarta ondata pandemica in relazione alle caratteristiche cliniche e allo stato vaccinale

Author

Gnerre, Paola, primary, Pasquali, Mercedes, additional, Aiosa, Giuseppe, additional, Daniele, Antonio, additional, Crivellari, Stefania, additional, Bertolotti, Marinella, additional, Salerno, Christian, additional, Di Dio, Angelo, additional, Pacileo, Guglielmo, additional, Maconi, Antonio, additional, and Marchisio, Sara, additional

Published
2022
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16. Additional file 1 of Acute cardiovascular events in patients with community acquired pneumonia: results from the observational prospective FADOI-ICECAP study

Author

Pieralli, Filippo, Vannucchi, Vieri, Nozzoli, Carlo, Augello, Giuseppe, Dentali, Francesco, Marzi, Giulia De, Uomo, Generoso, Risaliti, Filippo, Morbidoni, Laura, Mazzone, Antonino, Santini, Claudio, Tirotta, Daniela, Corradi, Francesco, Gerloni, Riccardo, Gnerre, Paola, Gussoni, Gualberto, Valerio, Antonella, Campanini, Mauro, Manfellotto, Dario, and Fontanella, Andrea

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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19. Outcomes of patients with COVID-19 hospitalized during the fourth pandemic wave in relation to their clinical features and vaccination status.

Author

Crivellari, Stefania, Pasquali, Mercedes, Aiosa, Giuseppe, Daniele, Antonio, Bertolotti, Marinella, Salerno, Christian, Pacileo, Guglielmo, Marchisio, Sara, Maconi, Antonio, and Gnerre, Paola

Abstract

This study aims to observe the clinical characteristics and outcomes of recovered patients from coronavirus disease 2019 (COVID-19) related to the vaccination status. We examined results of 205 COVID-19-recovered patients from 15 December 2021 to 1 March 2022 in two hospitals of Local Health Authority of Alessandria (Italy) during the fourth pandemic wave. 77% of patients were hospitalized for acute respiratory failure (ARF) with radiological pneumonia pattern (recovered for COVID), 23% for other causes with occasional positivity finding (recovered with COVID). 32% of patients were not vaccinated for SARS-CoV-2, 37% had three doses, 25% two doses, 5% only one dose. All patients without vaccination were hospitalized for ARF and they had a 7 times higher risk of hospitalization than the vaccinated. 60% of all patients had =3 comorbidities, of these 50% was vaccinated with three doses. In the fourth pandemic wave compared to the other not all patients were hospitalized for ARF and pneumonia and the presence of comorbidities =3 is a risk factor for hospitalization regardless of vaccination status. This justifies the administration of the fourth dose to frail patients. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Acute cardiovascular events in patients with community acquired pneumonia: results from the observational prospective FADOI-ICECAP study.

Author

Pieralli, Filippo, Vannucchi, Vieri, Nozzoli, Carlo, Augello, Giuseppe, Dentali, Francesco, De Marzi, Giulia, Uomo, Generoso, Risaliti, Filippo, Morbidoni, Laura, Mazzone, Antonino, Santini, Claudio, Tirotta, Daniela, Corradi, Francesco, Gerloni, Riccardo, Gnerre, Paola, Gussoni, Gualberto, Valerio, Antonella, Campanini, Mauro, Manfellotto, Dario, and Fontanella, Andrea

Subjects
COMMUNITY-acquired pneumonia, CARDIOVASCULAR diseases, TRANSIENT ischemic attack, ISCHEMIC stroke, HEMORRHAGIC stroke
Abstract

Background: The burden of cardiovascular (CV) complications in patients hospitalised for community-acquired pneumonia (CAP) is still uncertain. Available studies used different designs and different criteria to define CV complications. We assessed the cumulative incidence of acute of CV complications during hospitalisation for CAP in Internal Medicine Units (IMUs). Methods: This was a prospective study carried out in 26 IMUs, enrolling patients consecutively hospitalised for CAP. Defined CV complications were: newly diagnosed heart failure, acute coronary syndrome, new onset of supraventricular or ventricular arrhythmias, new onset hemorrhagic or ischemic stroke or transient ischemic attack. Outcome measures were: in-hospital and 30-day mortality, length of hospital stay and rate of 30-day re-hospitalisation. Results: A total of 1266 patients were enrolled, of these 23.8% experienced at least a CV event, the majority (15.5%) represented by newly diagnosed decompensated heart failure, and 75% occurring within 3 days. Female gender, a history of CV disease, and more severe pneumonia were predictors of CV events. In-hospital (12.2% vs 4.7%, p < 0.0001) and 30-day (16.3% vs 8.9%, p = 0.0001) mortality was higher in patients with CV events, as well as the re-hospitalisation rate (13.3% vs 9.3%, p = 0.002), and mean hospital stay was 11.4 ± 6.9 vs 9.5 ± 5.6 days (p < 0.0001). The occurrence of CV events during hospitalisation significantly increased the risk of 30-day mortality (HR 1.69, 95% CI 1.14–2.51; p = 0.009). Conclusion: Cardiovascular events are frequent in CAP, and their occurrence adversely affects outcome. A strict monitoring might be useful to intercept in-hospital CV complications for those patients with higher risk profile. Trial registration: NCT03798457 Registered 10 January 2019 - Retrospectively registered [ABSTRACT FROM AUTHOR]

Published
2021
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28. An update on methods for sarcopenia diagnosis: from bench to bedside

Author

Rossi, Andrea P., primary, Rubele, Sofia, additional, D'Introno, Alessia, additional, Zoico, Elena, additional, Bradimarte, Piero, additional, Amadio, Giulia, additional, Nori, Nicole, additional, Gnerre, Paola, additional, Mazzali, Gloria, additional, Fantin, Francesco, additional, and Zamboni, Mauro, additional

Published
2018
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29. Could clustering of comorbidities be useful for better defining the internal medicine patients’ complexity?

Author

Tangianu, Flavio, primary, Gnerre, Paola, additional, Colombo, Fabrizio, additional, Frediani, Roberto, additional, Pinna, Giuliano, additional, Berti, Franco, additional, Mathieu, Giovanni, additional, La Regina, Micaela, additional, Orlandini, Francesco, additional, Mazzone, Antonino, additional, Canale, Clelia, additional, Borioni, Daniele, additional, and Nardi, Roberto, additional

Published
2018
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37. Approach to leg edema

Author

Pomero, Fulvio, primary, Re, Roberta, additional, Meschi, Michele, additional, Montemurro, Domenico, additional, Spadafora, Laura, additional, Borretta, Valentina, additional, Zampogna, Monica, additional, Marchetti, Annalisa, additional, Di Lillo, Mariangela, additional, Tirotta, Daniela, additional, Bozzano, Chiara, additional, La Regina, Micaela, additional, and Gnerre, Paola, additional

Published
2017
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39. Pulmonary embolism prognostic factors and length of hospital stay: A cohort study

Author

Donadini, Marco Paolo, primary, Dentali, Francesco, additional, Castellaneta, Marco, additional, Gnerre, Paola, additional, La Regina, Micaela, additional, Masotti, Luca, additional, Pieralli, Filippo, additional, Pomero, Fulvio, additional, Re, Roberta, additional, Guasti, Luigina, additional, Ageno, Walter, additional, and Squizzato, Alessandro, additional

Published
2017
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45. Management of sepsis: from evidence to clinical practice

Author

Gerloni, Riccardo, primary, Mucci, Luciano, additional, Casati, Carlotta, additional, Crociani, Andrea, additional, Para, Ombretta, additional, Benetti, Elisabetta, additional, Gnerre, Paola, additional, Bovero, Anna, additional, Romagnoli, Elisa, additional, Tarquinio, Nicola, additional, Canale, Clelia, additional, Brancato, Davide, additional, Massarelli, Laura, additional, and Piras, Salvatora, additional

Published
2016
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49. Delirium: the invisible syndrome

Author

Gnerre, Paola, primary, La Regina, Micaela, additional, Bozzano, Chiara, additional, Pomero, Fulvio, additional, Re, Roberta, additional, Meschi, Michele, additional, Montemurro, Domenico, additional, Marchetti, Annalisa, additional, Di Lillo, Mariangela, additional, and Tirotta, Daniela, additional

Published
2016
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