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419 results on '"Gnecchi, Massimiliano"'

1. Therapeutic Efficacy of Mexiletine for Long QT Syndrome Type 2: Evidence From Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes, Transgenic Rabbits, and Patients

Author

Crotti, Lia, Neves, Raquel, Dagradi, Federica, Musu, Giulia, Giannetti, Federica, Bos, J. Martijn, Barbieri, Miriam, Cerea, Paolo, Giovenzana, Fulvio L.F., Torchio, Margherita, Mura, Manuela, Gnecchi, Massimiliano, Conte, Giulio, Auricchio, Angelo, Sala, Luca, Odening, Katja E., Ackerman, Michael J., and Schwartz, Peter J.

Published
2024
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2. Current challenges in cell and gene therapy: a joint view from the European Committee of the International Society for Cell & Gene Therapy (ISCT) and the European Society for Blood and Marrow Transplantation (EBMT)

Author

Sanchez-Guijo, Fermin, Vives, Joaquim, Ruggeri, Annalisa, Chabannon, Christian, Corbacioglu, Selim, Dolstra, Harry, Farge, Dominique, Gagelmann, Nico, Horgan, Claire, Kuball, Jurgen, Neven, Benedicte, Rintala, Tuula, Rocha, Vanderson, Sanchez-Ortega, Isabel, Snowden, John A., Zwaginga, Jaap Jan, Gnecchi, Massimiliano, and Sureda, Anna

Published
2024
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8. Pulmonary embolism in patients with COVID-19: characteristics and outcomes in the Cardio-COVID Italy multicenter study

Author

Ameri, Pietro, Inciardi, Riccardo M., Di Pasquale, Mattia, Agostoni, Piergiuseppe, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Danzi, Giambattista, Dalla Vecchia, Laura, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Anita, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Sinagra, Gianfranco, Tedino, Chiara, Tomasoni, Daniela, Volterrani, Maurizio, Zaccone, Gregorio, Lombardi, Carlo Mario, Senni, Michele, and Metra, Marco

Published
2021
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9. Machine learning for prediction of in-hospital mortality in coronavirus disease 2019 patients: results from an Italian multicenter study

Author

Vezzoli, Marika, Inciardi, Riccardo Maria, Oriecuia, Chiara, Paris, Sara, Murillo, Natalia Herrera, Agostoni, Piergiuseppe, Ameri, Pietro, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Danzi, Giambattista, Dalla Vecchia, Laura, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Anita, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Pagnesi, Matteo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Senni, Michele, Sinagra, Gianfranco, Tomasoni, Daniela, Adamo, Marianna, Volterrani, Maurizio, Maroldi, Roberto, Metra, Marco, Lombardi, Carlo Mario, and Specchia, Claudia

Published
2022
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10. Sex-related differences in patients with coronavirus disease 2019: results of the Cardio-COVID-Italy multicentre study

Author

Lombardi, Carlo Mario, Specchia, Claudia, Conforti, Fabio, Rovere, Maria Teresa La, Carubelli, Valentina, Agostoni, Piergiuseppe, Carugo, Stefano, Danzi, Gian Battista, Guazzi, Marco, Mortara, Andrea, Piepoli, Massimo, Porto, Italo, Sinagra, Gianfranco, Volterrani, Maurizio, Ameri, Pietro, Gnecchi, Massimiliano, Leonardi, Sergio, Merlo, Marco, Iorio, Annamaria, Bellasi, Antonio, Canale, Claudia, Camporotondo, Rita, Catagnano, Francesco, Dalla Vecchia, Laura Adelaide, Di Pasquale, Mattia, Giovinazzo, Stefano, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Monzo, Luca, Nuzzi, Vincenzo, Oriecuia, Chiara, Pala, Laura, Peveri, Giulia, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Adamo, Marianna, Tomasoni, Daniela, Inciardi, Riccardo Maria, Senni, Michele, and Metra, Marco

Published
2022
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11. Derivation and validation of the incomplete ST-segment resolution score and its usefulness for treatment with glycoprotein IIb-IIIa inhibitors

Author

Cornara, Stefano, primary, Mandurino-Mirizzi, Alessandro, additional, Somaschini, Alberto, additional, Mauri, Silvia, additional, Crimi, Gabriele, additional, Munafò, Andrea, additional, Camporotondo, Rita, additional, Gnecchi, Massimiliano, additional, De Servi, Stefano, additional, De Ferrari, Gaetano Maria, additional, and Ferlini, Marco, additional

Published
2023
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12. Beneficial Effects of IABP in Anterior Myocardial Infarction Complicated by Cardiogenic Shock

Author

Somaschini, Alberto, primary, Cornara, Stefano, additional, Leonardi, Sergio, additional, Demarchi, Andrea, additional, Mandurino-Mirizzi, Alessandro, additional, Fortuni, Federico, additional, Ferlini, Marco, additional, Crimi, Gabriele, additional, Camporotondo, Rita, additional, Gnecchi, Massimiliano, additional, Oltrona Visconti, Luigi, additional, De Servi, Stefano, additional, and De Ferrari, Gaetano Maria, additional

Published
2023
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17. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Author

Giannetti, Federica, primary, Barbieri, Miriam, additional, Shiti, Assad, additional, Casini, Simona, additional, Sager, Philip T, additional, Das, Saumya, additional, Pradhananga, Sabindra, additional, Srinivasan, Dinesh, additional, Nimani, Saranda, additional, Alerni, Nicolò, additional, Louradour, Julien, additional, Mura, Manuela, additional, Gnecchi, Massimiliano, additional, Brink, Paul, additional, Zehender, Manfred, additional, Koren, Gideon, additional, Zaza, Antonio, additional, Crotti, Lia, additional, Wilde, Arthur A M, additional, Schwartz, Peter J, additional, Remme, Carol Ann, additional, Gepstein, Lior, additional, Sala, Luca, additional, and Odening, Katja E, additional

Published
2023
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19. Abstract 13427: Extracellular Vesicles Improve Heart Function Without Inducing the Generation of New Cardiomyocytes

Author

Lima Correa, Bruna, El harane, Nadia, Perotto, Maria, Desgres, Manon, Guillas, Chloe, Alayrac, Paul, PIDIAL, LAETITIA, BELLAMY, VALERIE, tence, noemie, Baron, Emilie, Autret, Gwennhael, Kamaleswaran, Keirththana, Vilar, Jose, Alberdi, Antonio, Renault, Nisa, Gnecchi, Massimiliano, Menasche, Philippe, and Silvestre, Jean-Sebastien

Published
2020
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20. Comparison of Outcomes of Staged Complete Revascularization Versus Culprit Lesion–Only Revascularization for ST-Elevation Myocardial Infarction and Multivessel Coronary Artery Disease

Author

Marino, Marcello, Crimi, Gabriele, Leonardi, Sergio, Ferlini, Marco, Repetto, Alessandra, Camporotondo, Rita, Demarchi, Andrea, De Pascali, Ilaria, Falcinella, Francesca, Oltrona Visconti, Luigi, De Servi, Stefano, Ferrario, Maurizio, De Ferrari, Gaetano Maria, and Gnecchi, Massimiliano

Published
2017
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26. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Author

Giannetti, Federica, Barbieri, Miriam, Shiti, Assad, Casini, Simona, Sager, Philip T, Das, Saumya, Pradhananga, Sabindra, Srinivasan, Dinesh, Nimani, Saranda, Alerni, Nicolò, Louradour, Julien, Mura, Manuela, Gnecchi, Massimiliano, Brink, Paul, Zehender, Manfred, Koren, Gideon, Zaza, Antonio, Crotti, Lia, Wilde, Arthur A M, Schwartz, Peter J, Remme, Carol Ann, Gepstein, Lior, Sala, Luca, Odening, Katja E, Giannetti, F, Barbieri, M, Shiti, A, Casini, S, Sager, P, Das, S, Pradhananga, S, Srinivasan, D, Nimani, S, Alerni, N, Louradour, J, Mura, M, Gnecchi, M, Brink, P, Zehender, M, Koren, G, Zaza, A, Crotti, L, Wilde, A, Schwartz, P, Remme, C, Gepstein, L, Sala, L, and Odening, K

Subjects
Cellular electrophysiology, Physiology (medical), LQTS, Animal model, 610 Medicine & health, 610 Medizin und Gesundheit, Cardiology and Cardiovascular Medicine, Genotype-specific therapy, hiPSC, Mechanism-based therapy
Abstract

Aims Current long QT syndrome (LQTS) therapy, largely based on beta-blockade, does not prevent arrhythmias in all patients; therefore, novel therapies are warranted. Pharmacological inhibition of the serum/glucocorticoid-regulated kinase 1 (SGK1-Inh) has been shown to shorten action potential duration (APD) in LQTS type 3. We aimed to investigate whether SGK1-Inh could similarly shorten APD in LQTS types 1 and 2. Methods and results Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and hiPSC-cardiac cell sheets (CCS) were obtained from LQT1 and LQT2 patients; CMs were isolated from transgenic LQT1, LQT2, and wild-type (WT) rabbits. Serum/glucocorticoid-regulated kinase 1 inhibition effects (300 nM–10 µM) on field potential durations (FPD) were investigated in hiPSC-CMs with multielectrode arrays; optical mapping was performed in LQT2 CCS. Whole-cell and perforated patch clamp recordings were performed in isolated LQT1, LQT2, and WT rabbit CMs to investigate SGK1-Inh (3 µM) effects on APD. In all LQT2 models across different species (hiPSC-CMs, hiPSC-CCS, and rabbit CMs) and independent of the disease-causing variant (KCNH2-p.A561V/p.A614V/p.G628S/IVS9-28A/G), SGK1-Inh dose-dependently shortened FPD/APD at 0.3–10 µM (by 20–32%/25–30%/44–45%). Importantly, in LQT2 rabbit CMs, 3 µM SGK1-Inh normalized APD to its WT value. A significant FPD shortening was observed in KCNQ1-p.R594Q hiPSC-CMs at 1/3/10 µM (by 19/26/35%) and in KCNQ1-p.A341V hiPSC-CMs at 10 µM (by 29%). No SGK1-Inh-induced FPD/APD shortening effect was observed in LQT1 KCNQ1-p.A341V hiPSC-CMs or KCNQ1-p.Y315S rabbit CMs at 0.3–3 µM. Conclusion A robust SGK1-Inh-induced APD shortening was observed across different LQT2 models, species, and genetic variants but less consistently in LQT1 models. This suggests a genotype- and variant-specific beneficial effect of this novel therapeutic approach in LQTS.

Published
2023

28. Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions

Author

Wagner, Tanja, Traxler, Denise, Simader, Elisabeth, Beer, Lucian, Narzt, Marie-Sophie, Gruber, Florian, Madlener, Sibylle, Laggner, Maria, Erb, Michael, Vorstandlechner, Vera, Gugerell, Alfred, Radtke, Christine, Gnecchi, Massimiliano, Peterbauer, Anja, Gschwandtner, Maria, Tschachler, Erwin, Keibl, Claudia, Slezak, Paul, Ankersmit, Hendrik J., and Mildner, Michael

Published
2018
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31. From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022

Author

Evans, Paul C, Davidson, Sean M, Wojta, Johann, Bäck, Magnus, Bollini, Sveva, Brittan, Mairi, Catapano, Alberico L, Chaudhry, Bill, Cluitmans, Matthijs, Gnecchi, Massimiliano, Guzik, Tomasz J, Hoefer, Imo E, Madonna, Rosalinda, Monteiro, João P, Morawietz, Henning, Osto, Elena, Padró, Teresa, Sluimer, Judith C, Tocchetti, Carlo Gabriele, Van der Heiden, Kim, Vilahur, Gemma, Waltenberger, Johannes, Weber, Christian, Evans, Paul C, Davidson, Sean M, Wojta, Johann, Bäck, Magnu, Bollini, Sveva, Brittan, Mairi, Catapano, Alberico L, Chaudhry, Bill, Cluitmans, Matthij, Gnecchi, Massimiliano, Guzik, Tomasz J, Hoefer, Imo, Madonna, Rosalinda, Monteiro, João P, Morawietz, Henning, Osto, Elena, Padró, Teresa, Sluimer, Judith C, Tocchetti, Carlo Gabriele, Van der Heiden, Kim, Vilahur, Gemma, Waltenberger, Johanne, Weber, Christian, and University of Zurich

Subjects
vascular, 540 Chemistry, biomarker, 610 Medicine & health, Precision Medicine, 10038 Institute of Clinical Chemistry, CARDIOLOGY
Abstract

Here we review the highlights of cardiovascular basic science in published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell ‘omics are providing new insights in cardiovascular development, inflammation and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognised the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarise discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of cross-talk between hyperglycemia, lipid mediators and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell (iPSC) technology which has demonstrated disease causality for several genetic polymorphisms in long QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.

Published
2022

32. Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases

Author

Gyöngyösi, Mariann, primary, Alcaide, Pilar, additional, Asselbergs, Folkert W, additional, Brundel, Bianca J J M, additional, Camici, Giovanni G, additional, Martins, Paula da Costa, additional, Ferdinandy, Péter, additional, Fontana, Marianna, additional, Girao, Henrique, additional, Gnecchi, Massimiliano, additional, Gollmann-Tepeköylü, Can, additional, Kleinbongard, Petra, additional, Krieg, Thomas, additional, Madonna, Rosalinda, additional, Paillard, Melanie, additional, Pantazis, Antonis, additional, Perrino, Cinzia, additional, Pesce, Maurizio, additional, Schiattarella, Gabriele G, additional, Sluijter, Joost P G, additional, Steffens, Sabine, additional, Tschöpe, Carsten, additional, Van Linthout, Sophie, additional, and Davidson, Sean M, additional

Published
2022
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37. Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes

Author

Rocchetti, Marcella, Sala, Luca, Dreizehnter, Lisa, Crotti, Lia, Sinnecker, Daniel, Mura, Manuela, Pane, Luna Simona, Altomare, Claudia, Torre, Eleonora, Mostacciuolo, Gaspare, Severi, Stefano, Porta, Alberto, De Ferrari, Gaetano M., George, Alfred L, Jr, Schwartz, Peter J., Gnecchi, Massimiliano, Moretti, Alessandra, and Zaza, Antonio

Published
2017
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38. Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases

Author

Gyöngyösi, Mariann, Alcaide, Pilar, Asselbergs, Folkert W, Brundel, Bianca J J M, Camici, Giovanni G, Martins, Paula da Costa, Ferdinandy, Péter, Fontana, Marianna, Girao, Henrique, Gnecchi, Massimiliano, Gollmann-Tepeköylü, Can, Kleinbongard, Petra, Krieg, Thomas, Madonna, Rosalinda, Paillard, Melanie, Pantazis, Antonis, Perrino, Cinzia, Pesce, Maurizio, Schiattarella, Gabriele G, and Sluijter, Joost P G

Subjects
POST-acute COVID-19 syndrome, CYTOLOGY, PERICARDIUM diseases, CARDIOVASCULAR system, CARDIOMYOPATHIES, BLOOD coagulation, ORTHOSTATIC intolerance, PALPITATION
Abstract

Long COVID has become a world-wide, non-communicable epidemic, caused by long-lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection has already subsided. This scientific document aims to provide insight into the possible causes and therapeutic options available for the cardiovascular manifestations of long COVID. In addition to chronic fatigue, which is a common symptom of long COVID, patients may present with chest pain, ECG abnormalities, postural orthostatic tachycardia, or newly developed supraventricular or ventricular arrhythmias. Imaging of the heart and vessels has provided evidence of chronic, post-infectious perimyocarditis with consequent left or right ventricular failure, arterial wall inflammation, or microthrombosis in certain patient populations. Better understanding of the underlying cellular and molecular mechanisms of long COVID will aid in the development of effective treatment strategies for its cardiovascular manifestations. A number of mechanisms have been proposed, including those involving direct effects on the myocardium, microthrombotic damage to vessels or endothelium, or persistent inflammation. Unfortunately, existing circulating biomarkers, coagulation, and inflammatory markers, are not highly predictive for either the presence or outcome of long COVID when measured 3 months after SARS-CoV-2 infection. Further studies are needed to understand underlying mechanisms, identify specific biomarkers, and guide future preventive strategies or treatments to address long COVID and its cardiovascular sequelae. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Combined Role of Troponin and Natriuretic Peptides Measurements in Patients With Covid-19 (from the Cardio-COVID-Italy Multicenter Study)

Author

Iorio, Annamario, primary, Lombardi, Carlo Mario, additional, Specchia, Caludia, additional, Merlo, Marco, additional, Nuzzi, Vincenzo, additional, Ferraro, Ilenia, additional, Peveri, Giulia, additional, Oriecuia, Chiara, additional, Pozzi, Andrea, additional, Inciardi, Riccardo Maria, additional, Carubelli, Valentina, additional, Bellasi, Antonio, additional, Canale, Claudia, additional, Camporotondo, Rita, additional, Catagnano, Francesco, additional, Dalla Vecchia, Laura, additional, Giovinazzo, Stefano, additional, Maccagni, Gloria, additional, Mapelli, Massimo, additional, Margonato, Davide, additional, Monzo, Luca, additional, Provenzale, Giovanni, additional, Sarullo, Filippo, additional, Tomasoni, Daniela, additional, Ameri, Pietro, additional, Gnecchi, Massimiliano, additional, Leonardi, Sergio, additional, Agostoni, Piergiuseppe, additional, Carugo, Stefano, additional, Danzi, Gian Battista, additional, Guazzi, Marco, additional, La Rovere, Maria Teresa, additional, Mortara, Andrea, additional, Piepoli, Massimo, additional, Porto, Italo, additional, Volterrani, Maurizio, additional, Sinagra, Gianfranco, additional, Senni, Michele, additional, and Metra, Marco, additional

Published
2022
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45. 554 Machine learning for prediction of in-hospital mortality in COVID-19 patients: results from an Italian multicentre study

Author

Paris, Sara, primary, Inciardi, Riccardo Maria, additional, Specchia, Claudia, additional, Vezzoli, Marika, additional, Oriecuia, Chiara, additional, Lombardi, Carlo Mario, additional, Murillo, Natalia Herrera, additional, Pagnesi, Matteo, additional, Tomasoni, Daniela, additional, Ameri, Pietro, additional, Carubelli, Valentina, additional, Agostoni, Piergiuseppe, additional, Canale, Claudia, additional, Carugo, Stefano, additional, Danzi, Giambattista, additional, Pasquale, Mattia Di, additional, Sarullo, Filippo, additional, Rovere, Maria Teresa La, additional, Mortara, Andrea, additional, Piepoli, Massimo, additional, Porto, Italo, additional, Sinagra, Gianfranco, additional, Volterrani, Maurizio, additional, Gnecchi, Massimiliano, additional, Leonardi, Sergio, additional, Merlo, Marco, additional, Iorio, Annamaria, additional, Giovinazzo, Stefano, additional, Bellasi, Antonio, additional, Zaccone, Gregorio, additional, Camporotondo, Rita, additional, Catagnano, Francesco, additional, Vecchia, Laura Dalla, additional, Maccagni, Gloria, additional, Mapelli, Massimo, additional, Margonato, Davide, additional, Monzo, Luca, additional, Nuzzi, Vincenzo, additional, Pozzi, Andrea, additional, Provenzale, Giovanni, additional, Tedino, Chiara, additional, Guazzi, Marco, additional, Senni, Michele, additional, and Metra, Marco, additional

Published
2021
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47. Abstract 13767: Reaching the LDL-Cholesterol Target Recommended by the Guidelines: Be Ambitious to Get the Maximum Benefit

Author

Casula, Matteo, primary, Taietti, Ivan, additional, Galazzi, Marco, additional, Zeqaj, Iris, additional, Fortuni, Federico, additional, Cornara, Stefano, additional, Somaschini, Alberto, additional, Leonardi, Sergio, additional, Camporotondo, Rita, additional, Totaro, Rossana, additional, Ferlini, Marco, additional, and Gnecchi, Massimiliano, additional

Published
2021
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50. Determinants of the protective effect of glucocorticoids on mortality in hospitalized patients with COVID-19: Insights from the Cardio-COVID-Italy multicenter study

Author

Pagnesi, Matteo, Inciardi, Riccardo M., Lombardi, Carlo M., Agostoni, Piergiuseppe, Ameri, Pietro, Barbieri, Lucia, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Dalla Vecchia, Laura A., Danzi, Gian Battista, Di Pasquale, Mattia, Gaudenzi, Margherita, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Annamaria, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Sarullo, Filippo, Sinagra, Gianfranco, Tedino, Chiara, Tomasoni, Daniela, Volterrani, Maurizio, Zaccone, Gregorio, Senni, Michele, and Metra, Marco

Published
2021
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