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15. Triptans utilization in Italian population: A real-life study in community pharmacies

Author

Baratta, Francesca, primary, Allais, Gianni, additional, Gnavi, Roberto, additional, Scarinzi, Cecilia, additional, Enri, Lorenzo Ravetto, additional, Rolando, Sara, additional, Spadea, Teresa, additional, Costa, Giuseppe, additional, Benedetto, Chiara, additional, Mana, Massimo, additional, Giaccone, Mario, additional, Mandelli, Andrea, additional, Manzoni, Gian Camillo, additional, Bussone, Gennaro, additional, and Brusa, Paola, additional

Published
2023
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18. Monitoring and screening COPD in community pharmacies: experimentation in Italy

Author

Baratta, Francesca, Pignata, Irene, Onorati, Roberta, Gnavi, Roberto, Costa, Giuseppe, Brusa, Paola, Spadea, Teresa, Baratta, Francesca, Pignata, Irene, Onorati, Roberta, Gnavi, Roberto, Costa, Giuseppe, Brusa, Paola, and Spadea, Teresa

Abstract

Objective: COPD is one of the most important causes of morbidity and mortality worldwide. The health and economic burden of COPD may in part be reduced by early disease case finding and a correct therapy. This study aimed to investigate the feasibility of a community pharmacy programme for COPD case finding among previously undiagnosed subjects and for monitoring and enhancing adherence to prescribed pharmacological therapies among patients with confirmed COPD. Methods: The intervention was conducted in hundred community pharmacies in Piedmont (northwest Italy) and developed in two different arms: a case finding one through the administration of a specific questionnaire and the spirometry measurement and the adherence one through the administration of a questionnaire exploring the impact of the disease and the therapy adherence. Persons considered at risk to develop the COPD disease or non-controlled patients were referred to the GP or were invited to return in the pharmacy for a follow-up interview. Results: Overall, 844 subjects, out of 934 enrolled, completed the baseline interview. 103 subjects (25.7% of the 401 enrolled in the case finding arm) were considered at risk of suffering from COPD. Lower educated subjects and those without social support were more frequently at very high risk. Five returned to the pharmacy with a confirmed medical diagnosis. Among the 443 patients interviewed we found non-adherence value (depending on the drug) varying from 31% to 46%. A significant protection from non-adherence to bronchodilators was found among patients with comorbidities and among people living alone. Conclusions: We showed that opportunistic screening for COPD is feasible in community pharmacies. Concerning adherence to therapy in pharmacies, it would be necessary to identify different methods of enrolment in order to involve only those patients who are less adherent or who have difficulties in the management of therapy and chronic pathology

Published
2023

20. Risk of myocardial infarction and stroke after female breast cancer: analysis on a cohort of 1.3 million women

Author

Ricceri, Fulvio, primary, Favaro, Enrica, additional, Gilcrease, Gregory Winston, additional, Calabrese, Sara Claudia, additional, Ferracin, Elisa, additional, Cuonzo, Daniela Di, additional, Macciotta, Alessandra, additional, Catalano, Alberto, additional, Dansero, Lucia, additional, d’Errico, Angelo, additional, Franco, Pierfrancesco, additional, Numico, Gianmauro, additional, Gnavi, Roberto, additional, Costa, Giuseppe, additional, Pagano, Eva, additional, and Sacerdote, Carlotta, additional

Published
2023
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21. Multimorbidity and SARS-CoV-2–Related Outcomes: Analysis of a Cohort of Italian Patients

Author

Catalano, Alberto, primary, Dansero, Lucia, additional, Gilcrease, Winston, additional, Macciotta, Alessandra, additional, Saugo, Carlo, additional, Manfredi, Luca, additional, Gnavi, Roberto, additional, Strippoli, Elena, additional, Zengarini, Nicolás, additional, Caramello, Valeria, additional, Costa, Giuseppe, additional, Sacerdote, Carlotta, additional, and Ricceri, Fulvio, additional

Published
2023
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29. Indirect impact of the COVID-19 pandemic and its containment measures on social inequalities in hospital utilisation in Italy

Author

Di Girolamo, Chiara, primary, Gnavi, Roberto, additional, Landriscina, Tania, additional, Forni, Silvia, additional, Falcone, Manuele, additional, Calandrini, Enrico, additional, Cesaroni, Giulia, additional, Russo, Antonio, additional, Leoni, Olivia, additional, Fanizza, Caterina, additional, Allotta, Alessandra, additional, Costa, Giuseppe, additional, and Spadea, Teresa, additional

Published
2022
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30. Additional file 1 of Health status assessment of a population of asylum seekers in Northern Italy

Author

Manfredi, Luca, Sciannameo, Veronica, Destefanis, Cinzia, Prisecaru, Marta, Cossu, Giorgia, Gnavi, Roberto, Macciotta, Alessandra, Catalano, Alberto, Pepe, Roberto Raffaele, Sacerdote, Carlotta, and Ricceri, Fulvio

Abstract

Additional file 1. Additional information on Italian legislation, tree models algorithm details, Table 2 and Table 3 in details, results of logistic regression analysis to support the main findings.

Published
2022
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31. COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in Italy.

Author

Gnavi, Roberto, Eboli, Ilenia, Alboini, Paolo Emilio, D'Alfonso, Sandra, Picariello, Roberta, Costa, Giuseppe, and Leone, Maurizio

Subjects
*COVID-19 pandemic, *MULTIPLE sclerosis, *COVID-19, *ELECTRONIC health records, *INTENSIVE care units, *HOSPITAL admission & discharge
Abstract

People with multiple sclerosis (PWMS) are at high risk of being affected by the disruption of health services that occurred during the COVID-19 pandemic months. The aim of this study was to evaluate the effect of the pandemic on the health outcomes of PWMS. PWMS and MS-free residing in Piedmont (north-west of Italy) were identified from electronic health records and linked with the regional COVID-19 database, the hospital-discharge database, and the population registry. Both cohorts (9333 PWMS and 4,145,856 MS-free persons) were followed-up for access to swab testing, hospitalisation, access to the Intensive Care Unit (ICU), and death from 22 February 2020 to 30 April 2021. The relationship between the outcomes and MS was evaluated using a logistic model, which was adjusted for potential confounders. The rate of swab testing was higher in PWMS, but the positivity to infection was similar to that of MS-free subjects. PWMS had a higher risk of hospitalisation (OR = 1.74; 95% IC, 1.41–2.14), admission to ICU (OR = 1.79; 95% IC, 1.17–2.72), and a slight, albeit not statistically significant, increase in mortality (OR = 1.28; 95% IC, 0.79–2.06). Compared to the general population PWMS with COVID-19 had an increased risk of hospitalization and admission to the ICU; the mortality rate did not differ. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Validation of AN algorithm based on data of the health information systems (HIS) for the identification of dementia cases

Author

Bacigalupo, Ilaria, Lombardo, Flavia, Bargagli, Anna Maria, Cascini, Silvia, Agabiti, Nerina, Davoli, Marina, Scalmana, Silvia, Di Palma, Annalisa, Greco, Annarita, Rinaldi, Marina, Imperiale, Daniele, Secreto, Piero, Golini, Natalia, Gnavi, Roberto, Biagini, Carlo, Gualdani, Elisa, Francesconi, Paolo, Magliocchetti, Natalia, Di Fiandra, Teresa, and Vanacore, Nicola

Published
2021
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33. Identification of dementia and MCI cases in health information systems: An Italian validation study

Author

Bacigalupo, Ilaria, primary, Lombardo, Flavia L., additional, Bargagli, Anna Maria, additional, Cascini, Silvia, additional, Agabiti, Nera, additional, Davoli, Marina, additional, Scalmana, Silvia, additional, Palma, Annalisa Di, additional, Greco, Annarita, additional, Rinaldi, Marina, additional, Giordana, Roberta, additional, Imperiale, Daniele, additional, Secreto, Piero, additional, Golini, Natalia, additional, Gnavi, Roberto, additional, Lovaldi, Franca, additional, Biagini, Carlo A., additional, Gualdani, Elisa, additional, Francesconi, Paolo, additional, Magliocchetti, Natalia, additional, Fiandra, Teresa Di, additional, and Vanacore, Nicola, additional

Published
2022
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34. Indirect impact of Covid-19 on hospital care pathways in Italy

Author

Spadea, Teresa, Di Girolamo, Chiara, Landriscina, Tania, Leoni, Olivia, Forni, Silvia, Colais, Paola, Fanizza, Caterina, Allotta, Alessandra, Onorati, Roberta, Gnavi, Roberto, and Mimico-19 working group

Subjects
Male, medicine.medical_specialty, Lung Neoplasms, Coronavirus disease 2019 (COVID-19), Epidemiology, Science, Arthroplasty, Replacement, Hip, medicine.medical_treatment, MEDLINE, Breast Neoplasms, Article, medicine, Humans, Myocardial infarction, Arthroplasty, Replacement, Knee, Lung cancer, Retrospective Studies, Femoral neck, Multidisciplinary, SARS-CoV-2, business.industry, Health care, COVID-19, Prostatic Neoplasms, Retrospective cohort study, medicine.disease, Arthroplasty, Hospitalization, medicine.anatomical_structure, Italy, Quarantine, Orthopedic surgery, Emergency medicine, Medicine, ST Elevation Myocardial Infarction, Female, business
Abstract

Earlier in 2020, seven Italian regions, which cover 62% of the Italian population, set up the Mimico-19 network to monitor the side effects of the restrictive measures against Covid-19 on volumes and quality of care. To this aim, we retrospectively analysed hospital discharges data, computing twelve indicators of volume and performance in three clinical areas: cardiology, oncology, and orthopaedics. Weekly indicators for the period January–July 2020 were compared with the corresponding average for 2018–2019; comparisons were performed within 3 sub-periods: pre-lockdown, lockdown, and post-lockdown. The weekly trend of hospitalisations for ST-segment elevation myocardial infarction (STEMI) showed a 40% reduction, but the proportion of STEMI patients with a primary PTCA did not significantly change from previous years. Malignant neoplasms surgery volumes differed substantially by site, with a limited reduction for lung cancer (

Published
2021

35. Health Status Assessment of a Population of Asylum Seekers in Northern Italy

Author

Manfredi, Luca, primary, Sciannameo, Veronica, additional, Destefanis, Cinzia, additional, Prisecaru, Marta, additional, Cossu, Giorgia, additional, Gnavi, Roberto, additional, Macciotta, Alessandra, additional, Catalano, Alberto, additional, Pepe, Roberto Raffaele, additional, Sacerdote, Carlotta, additional, and Ricceri, Fulvio, additional

Published
2021
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36. Assessment of Non-Adherence to Oral Metformin and Atorvastatin Therapies: A Cross-Sectional Survey in Piedmont (Italy)

Author

Parente, Marco, Pignata, Irene, Gnavi, Roberto, Spadea, Teresa, Di Martino, Mirko, Baratta, Francesca, and Brusa, Paola

Subjects
lcsh:R5-920, Patient Preference and Adherence, community pharmacies, adherence to therapy, morisky test, Adherence to therapy, Community pharmacies, Green and Levine Medication Adherence Questionnaire, Morisky, lcsh:Medicine (General), Original Research
Abstract

Marco Parente,1 Irene Pignata,1 Roberto Gnavi,2 Teresa Spadea,2 Mirko Di Martino,3 Francesca Baratta,1 Paola Brusa1 1Department of Drug Science and Technology, University of Turin, Turin, Italy; 2Epidemiology Unit, ASL TO3, Grugliasco, Italy; 3Department of Epidemiology, Lazio Regional Health Service, Rome, ItalyCorrespondence: Paola BrusaDepartment of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, Turin 10125, ItalyTel +39 011 670 66 65Email paola.brusa@unito.itIntroduction: It is not possible to recover from chronic diseases; however, a healthy lifestyle and correct adherence to therapy can avoid complications and co-morbidities. The aim of this study was the cross-sectional evaluation, by means of a questionnaire, of real-world data on the prevalence of non-adherence to metformin and atorvastatin oral therapies in a sample of patients that attend community pharmacies in the Piedmont Region. The secondary aim was to evaluate the presence of correlations between non-adherence and a number of variables detected by the questionnaire.Materials and Methods: Data were gathered from face-to-face interviews in six community pharmacies in Piedmont. The questionnaire was divided into two sections: the first included the Morisky, Green and Levine Medication Adherence Questionnaire(MAQ) (to assess therapy adherence); the second included questions on gender, age, level of education and the pharmacy in which the questionnaire was administered. Comparisons between proportions and mean values were performed using the χ 2 test. Modified Poisson regression with robust standard errors was used for multivariate analysis. The level of significance was fixed at 0.05, CI at 95%.Results: The sample analysed was composed of 408 subjects (receiving either metformin or atorvastatin). According to MAQ, 62 patients were non-adherent (15% of the total cohort). Crude and multivariate analysis did not show any statistically significant correlation between gender, age, level of education and non-adherence. It emerged that there was a correlation between non-adherence and being a customer of two of the pharmacies involved [PR = 3.31 (p=0.028) and PR = 3.11 (p=0.027)].Conclusions: Community pharmacies can be an appropriate setting to identify non-adherent patients. Therefore, healthcare professionals could realize an integrated and structured intervention to improve adherence. However, MAQ could underestimate the number of non-adherent patients. Further studies to test the association between non-adherence prevalence and being the customer of a specific pharmacy should be performed.Keywords: community pharmacies, Morisky, Green and Levine Medication Adherence Questionnaire, adherence to therapy

Published
2020

37. An update on the incidence of type 1 diabetes during the COVID‐19 pandemic years.

Author

Giorda, Carlo Bruno, Gnavi, Roberto, Tartaglino, Barbara, Favella, Lucia, Romeo, Francesco, Migliardi, Alessandro, Ferro, Silvia, and Rabbone, Ivana

Subjects
*TYPE 1 diabetes, *COVID-19 pandemic, *POST-acute COVID-19 syndrome, *AVIAN influenza, *ANGIOTENSIN converting enzyme, *SARS-CoV-2
Abstract

2 TABLE Raw incidence rates (IR) of type 1 diabetes in Piedmont (Italy) by 100 000 residents and rate ratios (RR), comparison between before and during the COVID pandemic years. Nevertheless, over the 3 years of the COVID-19 pandemic, the overall incidence of DM1 has remained ~17% higher than before the pandemic, suggesting further work to understand the link between coronaviruses and diabetes is a priority. Keywords: database research; observational; population study; study; type 1 diabetes EN database research observational population study study type 1 diabetes 3068 3070 3 09/06/23 20231001 NES 231001 BACKGROUND There have now been several reports that the incidence of type 1 diabetes (DM1) increased during the COVID-19 pandemic, particularly in young children,[[1], [3]] although some data are conflicting.[4] Overall, however, there is emerging evidence from diabetes registries that this observed increase is real. [Extracted from the article]

Published
2023
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39. Monitoring adherence to pharmacological therapy and follow-up examinations among patients with type 2 diabetes in community pharmacies. Results from an experience in Italy

Author

Spadea, Teresa, primary, Onorati, Roberta, additional, Baratta, Francesca, additional, Pignata, Irene, additional, Parente, Marco, additional, Pannacci, Lavinia, additional, Ancona, Domenica, additional, Ribecco, Paola, additional, Costa, Giuseppe, additional, Gnavi, Roberto, additional, and Brusa, Paola, additional

Published
2021
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43. Socioeconomic inequalities in coronary heart disease in Italy: a multilevel population-based study

Author

Petrelli, Alessio, Gnavi, Roberto, Marinacci, Chiara, and Costa, Giuseppe

Subjects
Coronary heart disease -- Economic aspects, Coronary heart disease -- Social aspects, Coronary heart disease -- Research, Social classes -- Health aspects, Social classes -- Research, Health, Social sciences
Abstract

This longitudinal study evaluates the role of individual and contextual socioeconomic determinants in the socioeconomic inequalities in incidence and mortality for coronary events in Turin, Italy, using hierarchical models. All residents aged 35-74 at the start of 1997 were included in the study population. We considered as outcomes all incident cases and deaths that occurred in the study population in the period 1997-2002. The socioeconomic indicators were educational level, job status and median income per census tract. A neighbourhood deprivation index was also used, which combines, in an aggregated measure, a series of poor individual socioeconomic conditions. The analyses were performed using hierarchical Poisson models, with individuals (n = 523,755) considered as level I units and neighbourhoods (n = 23) as level II units. Among men, we observed an inverse gradient in incidence by educational level and an excess risk for persons who were not actively employed. More marked excesses were found for mortality (RR: 1.63; 95% CI: 1.05-2.55, for unemployed persons compared to employed persons). Among women, greater socioeconomic differences were observed for both incidence and mortality; all of the individual indicators contributed to these differences. The differentials in mortality were particularly great for the retired and for housewives (RR: 1.98; 95% CI: 1.40-2.81). Slight excesses in incidence were observed among men for the most deprived areas. The results of this study reveal that job status is the most important individual factor explaining socioeconomic inequalities for coronary events, whereas context seems to play a marginal role. Keywords: Coronary events; Socioeconomic inequalities; Contextual effects; Hierarchical models; Italy; Gender

Published
2006

46. Validation of an Algorithm to Detect Multiple Sclerosis Cases in Administrative Health Databases in Piedmont (Italy): An Application to the Estimate of Prevalence by Age and Urbanization Level

Author

Gnavi, Roberto, primary, Picariello, Roberta, additional, Alboini, Paolo Emilio, additional, Cavalla, Paola, additional, Grasso, Maria Federica, additional, Richiardi, Paola, additional, Bertolotto, Antonio, additional, Barizzone, Nadia, additional, Cantello, Roberto, additional, Leone, Maurizio Angelo, additional, D’Alfonso, Sandra, additional, and Golini, Natalia, additional

Published
2021
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