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1. Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study

Author

Hafizi, Hasan, Aliko, Anila, Bardhi, Donika, Tafa, Holta, Thanasi, Natasha, Mezini, Arian, Teferici, Alma, Todri, Dafina, Nikolla, Jolanda, Kazasi, Rezarta, Cherkaski, Hamid Hacene, Bengrait, Amira, Haddad, Tabarek, Zgaoula, Ibtissem, Ghit, Maamar, Roubhia, Abdelhamid, Boudra, Soumaya, Atoui, Feryal, Yakoubi, Randa, Benali, Rachid, Bencheikh, Abdelghani, Ait-Khaled, Nadia, Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Studnicka, Michael, Dawes, Torkil, Lamprecht, Bernd, Schirhofer, Lea, Islam, Akramul, Ahmed, Syed Masud, Islam, Shayla, Islam, Qazi Shafayetul, Mesbah-Ul-Haque, Chowdhury, Tridib Roy, Chatterjee, Sukantha Kumar, Mia, Dulal, Chandra Das, Shyamal, Rahman, Mizanur, Islam, Nazrul, Uddin, Shahaz, Islam, Nurul, Khatun, Luiza, Parvin, Monira, Khan, Abdul Awal, Islam, Maidul, Lawin, Herve, Kpangon, Arsene, Kpossou, Karl, Agodokpessi, Gildas, Ayelo, Paul, Fayomi, Benjamin, Mbatchou, Bertrand, Ashu, Atongno Humphrey, Tan, Wan C., Wang, Wen, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jin-ping, Zhou, Yumin, Jogi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Adegnika, Ayola Akim, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, SchwedaLinow, Alexandra, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jorundsdottir, Kristin, Lovisa Gudmundsdottir, Gudmundsdottir, Sigrun, Gudmundsson, Gunnar, Rao, Mahesh, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Juvekar, Sanjay, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Salvi, Sundeep, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Aquart-Stewart, Althea, Aikman, Akosua Francia, Sooronbaev, Talant M., Estebesova, Bermet M., Akmatalieva, Meerim, Usenbaeva, Saadat, Kydyrova, Jypara, Bostonova, Eliza, Sheraliev, Ulan, Marajapov, Nuridin, Toktogulova, Nurgul, Emilov, Berik, Azilova, Toktogul, Beishekeeva, Gulnara, Dononbaeva, Nasyikat, Tabyshova, Aijamal, Mortimer, Kevin, Nyapigoti, Wezzie, Mwangoka, Ernest, Kambwili, Mayamiko, Chipeta, Martha, Banda, Gloria, Mkandawire, Suzgo, Banda, Justice, Loh, Li-Cher, Rashid, Abdul, Sholehah, Siti, Benjelloun, Mohamed C., Nejjari, Chakib, Elbiaze, Mohamed, El Rhazi, Karima, Wouters, E.F.M., Wesseling, G.J., Obaseki, Daniel, Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Nafees, Asaad A., Irfan, Muhammad, Fatmi, Zafar, Zahidie, Aysha, Shaukat, Natasha, Iqbal, Meesha, Idolor, Luisito F., de Guia, Teresita S., Francisco, Norberto A., Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Jr., Reyes, Maria Teresita N., Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Garcia, Gerard S., Naval, Sullian S., Reyes, Thessa, Roa, Camilo C., Jr., Sanchez, Flordeliza, Simpao, Leander P., Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Barbara, Cristina, Rodrigues, Fatima, Dias, Herminia, Cardoso, Joao, Almeida, João, Matos, Maria Joao, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Al Ghobain, M., Alorainy, H., El-Hamad, E., Al Hajjaj, M., Hashi, A., Dela, R., Fanuncio, R., Doloriel, E., Marciano, I., Safia, L., Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gunasekera, Kirthi, Wickremasinghe, Rajitha, Elsony, Asma, Elsadig, Hana A., Osman, Nada Bakery, Noory, Bandar Salah, Mohamed, Monjda Awad, Akasha Ahmed Osman, Hasab Alrasoul, Moham ed Elhassan, Namarig, El Zain, Abdel Mu’is, Mohamaden, Marwa Mohamed, Khalifa, Suhaiba, Elhadi, Mahmoud, Hassan, Mohand, Abdelmonam, Dalia, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, SpetzNystrom, Ulrike, Hagg, Gunilla, Lund, GunMarie, Seemungal, Terence, Lutchmansingh, Fallon, Conyette, Liane, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Kocabas, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Burney, Peter G.J., Gnatiuc, Louisa, Azar, Hadia, Patel, Jaymini, Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Dudhaiya, Risha, Buist, A. Sonia, McBurnie, Mary Ann, Vollmer, William M., Gillespie, Suzanne, Sullivan, Sean, Lee, Todd A., Weiss, Kevin B., Jensen, Robert L., Crapo, Robert, Enright, Paul, Mannino, David M., Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Abozid, Hazim, Burney, Peter, Hartl, Sylvia, Breyer-Kohansal, Robab, Al Ghobain, Mohammed, Denguezli, Meriam, Loh, Li Cher, Paraguas, Stefanni Nonna, Franssen, Frits M.E., Mannino, David, Anand, Mahesh Padukudru, Buist, Sonia, El Sony, Asma, Breyer, Marie-Kathrin, Burghuber, Otto C., Wouters, Emiel F.M., and Amaral, Andre F.S.

Published
2024
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2. Adiposity and cause-specific mortality in the Mexico City Prospective Study

Author

Gnatiuc, Louisa, Emberson, Jonathan, and Clarke, Robert

Subjects
362.1963
Abstract

Background: Previous studies have reported conflicting results about the associations of adiposity with risk of all-cause mortality in Hispanic populations. Moreover, the relevance of different markers of adiposity for cause-specific mortality may differ between Hispanic and other populations. Methods: Between 1998 and 2004, 159 755 adults aged ≥35 years from Mexico City were enrolled into a prospective study. Follow-up for cause-specific mortality was until 1st January 2018. Cox regression was used to estimate the relative risks (RRs) of death from specific causes associated with general adiposity (total body mass [BMI] and fat mass index [FMI]) and with abdominal adiposity (waist circumference, waist-hip ratio [WHR], and waist-height ratio [WHtR]), both overall and independently of each other, after adjustment for confounders. To minimise bias from reverse causation, the main analyses excluded those with screen-detected or diagnosed diabetes, other chronic diseases, and deaths in the first 5 years of follow-up. Excess attributable mortality and survival curves were derived from the RRs combined with national mortality rates. Results: Among those aged 35-89 years when recruited, mean (standard deviation [SD]) BMI was 29.5 (4.9) kg/m2 and 34% were obese (>30 kg/m2). Both BMI and FMI had J-shaped associations with all-cause mortality, whereas waist circumference, WHR and WHtR were all linearly and positively related to mortality throughout the ranges studied. Each 5 kg/m2 higher BMI above 25 kg/m² was associated with 32% higher risk of death at ages 40-74 years, chiefly due to a 38% higher risk of death from vascular or metabolic diseases. Across the full ranges, 1 SD higher levels of the adiposity markers were associated with 21% higher mortality at ages 40-74 years for BMI, 22% higher mortality for FMI, 25% higher mortality for waist circumference, 17% higher mortality for WHR, and 26% higher mortality for WHtR. For deaths from a vascular or metabolic cause, these estimates were 29%, 31%, 32%, 24% and 37%, respectively. Adjustment of BMI, WHR and WHtR for other markers of adiposity resulted in only a modest attenuation of the strength of the associations of these markers with mortality. By contrast, adjustment of waist circumference for the other markers of adiposity strengthened its association with mortality. Similarly, after adjustment for lean mass index, the association of FMI with all-cause mortality was strengthened. The various adiposity markers also displayed associations with several non-vascular non-metabolic causes of death. In particular, all of the adiposity markers were strongly related to death from respiratory and infective causes, but none were strongly associated with cancer mortality. Associations were broadly similar in men and women, somewhat stronger at younger than at older ages, and consistent according to levels of other confounders. Sensitivity analyses replicated the results of the main findings. Among those with diabetes, adiposity (particularly BMI) was inversely related to mortality, reflecting a reversal of causality caused by weight loss resulting from poor glycaemic control. The excess mortality associated with BMI above 30 kg/m² compared with BMI below 25 kg/m² accounted for 14% of all vascular and metabolic deaths. Applying the findings to current national Mexican death rates, compared with a BMI of 25 kg/m² life expectancy from age 40 years was reduced by about 3 years at a BMI of 30 kg/m², but by almost 10 years at a BMI of 40 kg/m². Conclusions: Consistent with findings in Western populations, both general, and especially, abdominal adiposity, were strongly predictive of all-cause and cause-specific mortality in this Mexican cohort, thereby refuting the 'Hispanic obesity paradox'. The failure of previous studies of Hispanic populations to detect such associations is likely due to their failure to account for reverse causality bias (arising from weight loss due to poorly controlled diabetes). Further studies are needed to elucidate the causal relevance of the associations with different markers of adiposity, and to determine the mechanisms underlying such associations.

Published
2020

6. Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study

Author

Ratanachina, Jate, Amaral, Andre F.S., De Matteis, Sara, Lawin, Herve, Mortimer, Kevin, Obaseki, Daniel O., Harrabi, Imed, Denguezli, Meriam, Wouters, Emiel F.M., Janson, Christer, Nielsen, Rune, Gulsvik, Amund, Cherkaski, Hamid Hacene, Mejza, Filip, Mahesh, Padukudru Anand, Elsony, Asma, Ahmed, Rana, Tan, Wan C., Loh, Li Cher, Rashid, Abdul, Studnicka, Michael, Nafees, Asaad A., Seemungal, Terence, Aquart-Stewart, Althea, Al Ghobain, Mohammed, Zheng, Jinping, Juvekar, Sanjay, Salvi, Sundeep, Jogi, Rain, Mannino, David M., Gislason, Thorarinn, Buist, A. Sonia, Cullinan, Paul, Burney, Peter G.J., Hafizi, Hasan, Aliko, Anila, Bardhi, Donika, Tafa, Holta, Thanasi, Natasha, Mezini, Arian, Teferici, Alma, Todri, Dafina, Nikolla, Jolanda, Kazasi, Rezarta, Bengrait, Amira, Haddad, Tabarek, Zgaoula, Ibtissem, Ghit, Maamar, Roubhia, Abdelhamid, Boudra, Soumaya, Atoui, Feryal, Yakoubi, Randa, Benali, Rachid, Bencheikh, Abdelghani, Ait-Khaled, Nadia, Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Dawes, Torkil, Lamprecht, Bernd, Schirhofer, Lea, Islam, Akramul, Ahmed, Syed Masud, Islam, Shayla, Islam, Qazi Shafayetul, Mesbah-Ul-Haque, NN, Chowdhury, Tridib Roy, Chatterjee, Sukantha Kumar, Mia, Dulal, Das, Shyamal Chandra, Rahman, Mizanur, Islam, Nazrul, Uddin, Shahaz, Islam, Nurul, Khatun, Luiza, Parvin, Monira, Khan, Abdul Awal, Islam, Maidul, Kpangon, Arsene, Kpossou, Karl, Agodokpessi, Gildas, Ayelo, Paul, Fayomi, Benjamin, Mbatchou, Bertrand, Ashu, Atongno Humphrey, Wang, Wen, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zhou, Yumin, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Adegnika, Ayola Akim, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, Schweda-Linow, Alexandra, Benedikdtsdottir, Bryndis, Jörundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Brashier, Sundeep Bill, Londhe, Jyoti, Madas, Sapna, Aikman, Althea Akosua Francia, Sooronbaev, Talant M., Estebesova, Bermet M., Akmatalieva, Meerim, Usenbaeva, Saadat, Kydyrova, Jypara, Bostonova, Eliza, Sheraliev, Ulan, Marajapov, Nuridin, Toktogulova, Nurgul, Emilov, Berik, Azilova, Toktogul, Beishekeeva, Gulnara, Dononbaeva, Nasyikat, Tabyshova, Aijamal, Mwangoka, Ernest, Kambwili, Mayamiko, Chipeta, Martha, Banda, Gloria, Mkandawire, Suzgo, Banda, Justice, Sholehah, Siti, Benjelloun, Mohamed C., Nejjari, Chakib, Elbiaze, Mohamed, El Rhazi, Karima, Franssen, F.F.E., Wesseling, G.J., Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Endresen, Tina, Svendsen, Lene Løvendahl, Irfan, Muhammad, Fatmi, Zafar, Zahidie, Aysha, Shaukat, Natasha, Iqbal, Meesha, Idolor, Luisito F., de Guia, Teresita S., Francisco, Norberto A., Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Reyes, Maria Teresita N., Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Garcia, Gerard S., Naval, Sullian S., Reyes, Thessa, Sanchez, Ma. Flordeliza, Simpao, Leander P., Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Bárbara, Cristina, Rodrigues, Fátima, Dias, Hermínia, Cardoso, João, Almeida, João, Matos, Maria João, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Alorainy, H., El-Hamad, E., Al Hajjaj, Hajjaj, Hashi, A., Dela, R., Fanuncio, R., Doloriel, E., Marciano, I., Safia, L., Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gunasekera, Kirthi, Wickremasinghe, Rajitha, Elsadig, Hana A., Osman, Nada Bakery, Noory, Bandar Salah, Mohamed, Monjda Awad, Osman, Hasab Alrasoul Akasha Ahmed, ed Elhassan, Namarig Moham, El Zain, Abdel Mu'is, Mohamaden, Marwa Mohamed, Khalifa, Suhaiba, Elhadi, Mahmoud, Hassan, Mohand, Abdelmonam, Dalia, Kamal, Rashid, Eltigani, Hind, Umar, Stephen's, Abdeen, Aya, Osman, Mihad, Mohamed, Malaz, Eltayeb, Roa, Abelazeez, Mohamed, Altaher, Hoyam, Mohamed, Lina, Abdarahman, Rabee, Mohamed, Rayan, Haram, NN, Ismaeel, Rimaz, Olafsdottir, Inga Sif, Nisser, Katarina, Spetz-Nyström, Ulrike, Hägg, Gunilla, Lund, Gun-Marie, Lutchmansingh, Fallon, Conyette, Liane, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Kocabaş, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Gnatiuc, Louisa, Azar, Hadia, Patel, Jaymini, Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Dudhaiya, Risha, McBurnie, Mary Ann, Vollmer, William M., Gillespie, Suzanne, Sullivan, Sean, Lee, Todd A., Weiss, Kevin B., Jensen, Robert L., Crapo, Robert, Enright, Paul, Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, and RS: NUTRIM - R3 - Respiratory & Age-related Health

Subjects
Pulmonary and Respiratory Medicine, Arbetsmedicin och miljömedicin, Respiratory Medicine and Allergy, Occupational Health and Environmental Health, Lungmedicin och allergi
Abstract

BackgroundChronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study.MethodsWe analysed cross-sectional data from 28 823 adults (≥40 years) in 34 countries. We considered 11 occupations and grouped them by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)/FVC with occupation was assessed, per study site, using multivariable regression. These estimates were then meta-analysed. Sensitivity analyses explored differences between sexes and gross national income.ResultsOverall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20 years were more likely to have chronic cough (OR 1.52, 95% CI 1.19–1.94), wheeze (OR 1.37, 95% CI 1.16–1.63) and dyspnoea (OR 1.83, 95% CI 1.53–2.20), but not lower FVC (β=0.02 L, 95% CI −0.02–0.06 L) or lower FEV1/FVC (β=0.04%, 95% CI −0.49–0.58%). Some findings differed by sex and gross national income.ConclusionAt a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they are associated with more respiratory symptoms. Because not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.

Published
2022

7. Association of Kidney Function With NMR-Quantified Lipids, Lipoproteins, and Metabolic Measures in Mexican Adults

Author

Aguilar-Ramirez, Diego, primary, Alegre-Díaz, Jesus, additional, Herrington, William G, additional, Staplin, Natalie, additional, Ramirez-Reyes, Raúl, additional, Gnatiuc, Louisa, additional, Hill, Michael, additional, Romer, Frederik, additional, Torres, Jason, additional, Trichia, Eirini, additional, Wade, Rachel, additional, Collins, Rory, additional, Emberson, Jonathan R, additional, Kuri-Morales, Pablo, additional, and Tapia-Conyer, Roberto, additional

Published
2021
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8. Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study

Author

Burney, Peter, primary, Patel, Jaymini, additional, Minelli, Cosetta, additional, Gnatiuc, Louisa, additional, Amaral, André F. S., additional, Kocabaş, Ali, additional, Cherkaski, Hamid Hacene, additional, Gulsvik, Amund, additional, Nielsen, Rune, additional, Bateman, Eric, additional, Jithoo, Anamika, additional, Mortimer, Kevin, additional, Sooronbaev, Talant M., additional, Lawin, Hervé, additional, Nejjari, Chakib, additional, Elbiaze, Mohammed, additional, El Rhazi, Karima, additional, Zheng, Jin-Ping, additional, Ran, Pixin, additional, Welte, Tobias, additional, Obaseki, Daniel, additional, Erhabor, Gregory, additional, Elsony, Asma, additional, Osman, Nada Bakri, additional, Ahmed, Rana, additional, Nizankowska-Mogilnicka, Ewa, additional, Mejza, Filip, additional, Mannino, David M., additional, Bárbara, Cristina, additional, Wouters, Emiel F. M., additional, Idolor, Luisito F., additional, Loh, Li-Cher, additional, Rashid, Abdul, additional, Juvekar, Sanjay, additional, Gislason, Thorarinn, additional, Al Ghobain, Mohamed, additional, Studnicka, Michael, additional, Harrabi, Imed, additional, Denguezli, Meriam, additional, Koul, Parvaiz A., additional, Jenkins, Christine, additional, Marks, Guy, additional, Jõgi, Rain, additional, Hafizi, Hasan, additional, Janson, Christer, additional, Tan, Wan C., additional, Aquart-Stewart, Althea, additional, Mbatchou, Bertrand, additional, Nafees, Asaad Ahmed, additional, Gunasekera, Kirthi, additional, Seemungal, Terry, additional, Anand, Mahesh Padukudru, additional, Enright, Paul, additional, Vollmer, William M., additional, Blangiardo, Marta, additional, Elfadaly, Fadlalla G., additional, Buist, A. Sonia, additional, Aliko, Anila, additional, Bardhi, Donika, additional, Tafa, Holta, additional, Thanasi, Natasha, additional, Mezini, Arian, additional, Teferici, Alma, additional, Todri, Dafina, additional, Nikolla, Jolanda, additional, Kazasi, Rezarta, additional, Bengrait, Amira, additional, Haddad, Tabarek, additional, Zgaoula, Ibtissem, additional, Ghit, Maamar, additional, Roubhia, Abdelhamid, additional, Boudra, Soumaya, additional, Atoui, Feryal, additional, Yakoubi, Randa, additional, Benali, Rachid, additional, Bencheikh, Abdelghani, additional, Ait-Khaled, Nadia, additional, Bird, Tessa, additional, Espinel, Paola, additional, Hardaker, Kate, additional, Toelle, Brett, additional, Dawes, Torkil, additional, Lamprecht, Bernd, additional, Schirhofer, Lea, additional, Islam, Akramul, additional, Ahmed, Syed Masud, additional, Islam, Shayla, additional, Islam, Qazi Shafayetul, additional, Chowdhury, Tridib Roy, additional, Chatterjee, Sukantha Kumar, additional, Mia, Dulal, additional, Das, Shyamal Chandra, additional, Rahman, Mizanur, additional, Islam, Nazrul, additional, Uddin, Shahaz, additional, Islam, Nurul, additional, Khatun, Luiza, additional, Parvin, Monira, additional, Khan, Abdul Awal, additional, Islam, Maidul, additional, Lawin, Herve, additional, Kpangon, Arsene, additional, Kpossou, Karl, additional, Agodokpessi, Gildas, additional, Ayelo, Paul, additional, Fayomi, Benjamin, additional, Ashu, Atongno Humphrey, additional, Wang, Wen, additional, Zhong, NanShan, additional, Liu, Shengming, additional, Lu, Jiachun, additional, Wang, Dali, additional, Zheng, Jin-ping, additional, Zhou, Yumin, additional, Laja, Hendrik, additional, Ulst, Katrin, additional, Zobel, Vappu, additional, Lill, Toomas-Julius, additional, Adegnika, Ayola Akim, additional, Bodemann, Isabelle, additional, Geldmacher, Henning, additional, Schweda-Linow, Alexandra, additional, Benedikdtsdottir, Bryndis, additional, Jörundsdottir, Kristin, additional, Gudmundsdottir, Lovisa, additional, Gudmundsdottir, Sigrun, additional, Gudmundsson, Gunnar, additional, Rao, Mahesh, additional, Malik, Sajjad, additional, Hakim, Nissar A., additional, Khan, Umar Hafiz, additional, Chowgule, Rohini, additional, Shetye, Vasant, additional, Raphael, Jonelle, additional, Almeda, Rosel, additional, Tawde, Mahesh, additional, Tadvi, Rafiq, additional, Katkar, Sunil, additional, Kadam, Milind, additional, Dhanawade, Rupesh, additional, Ghurup, Umesh, additional, Hirve, Siddhi, additional, Sambhudas, Somnath, additional, Chaidhary, Bharat, additional, Tambe, Meera, additional, Pingale, Savita, additional, Umap, Arati, additional, Umap, Archana, additional, Shelar, Nitin, additional, Devchakke, Sampada, additional, Chaudhary, Sharda, additional, Bondre, Suvarna, additional, Walke, Savita, additional, Gawhane, Ashleshsa, additional, Sapkal, Anil, additional, Argade, Rupali, additional, Gaikwad, Vijay, additional, Salvi, Sundeep, additional, Brashier, Bill, additional, Londhe, Jyoti, additional, Madas, Sapna, additional, Aikman, Akosua Francia, additional, Estebesova, Bermet M., additional, Akmatalieva, Meerim, additional, Usenbaeva, Saadat, additional, Kydyrova, Jypara, additional, Bostonova, Eliza, additional, Sheraliev, Ulan, additional, Marajapov, Nuridin, additional, Toktogulova, Nurgul, additional, Emilov, Berik, additional, Azilova, Toktogul, additional, Beishekeeva, Gulnara, additional, Dononbaeva, Nasyikat, additional, Tabyshova, Aijamal, additional, Nyapigoti, Wezzie, additional, Mwangoka, Ernest, additional, Kambwili, Mayamiko, additional, Chipeta, Martha, additional, Banda, Gloria, additional, Mkandawire, Suzgo, additional, Banda, Justice, additional, Sholehah, Siti, additional, Benjelloun, Mohamed C., additional, Elbiaze, Mohamed, additional, Wouters, E. F. M., additional, Wesseling, G. J., additional, Awopeju, Olayemi, additional, Adewole, Olufemi, additional, Endresen, Tina, additional, Svendsen, Lene, additional, Nafees, Asaad A., additional, de Guia, Teresita S., additional, Francisco, Norberto A., additional, Roa, Camilo C., additional, Ayuyao, Fernando G., additional, Tady, Cecil Z., additional, Tan, Daniel T., additional, Banal-Yang, Sylvia, additional, Balanag, Vincent M., additional, Reyes, Maria Teresita N., additional, Dantes, Renato. B., additional, Dantes, Renato B., additional, Amarillo, Lourdes, additional, Berratio, Lakan U., additional, Fernandez, Lenora C., additional, Garcia, Gerard S., additional, Naval, Sullian S., additional, Reyes, Thessa, additional, Sanchez, Ma. Flordeliza, additional, Simpao, Leander P., additional, Frey, Jakub, additional, Harat, Rafal, additional, Nastalek, Pawel, additional, Pajak, Andrzej, additional, Skucha, Wojciech, additional, Szczeklik, Andrzej, additional, Twardowska, Magda, additional, Rodrigues, Fátima, additional, Dias, Hermínia, additional, Cardoso, João, additional, Almeida, João, additional, Matos, Maria João, additional, Simão, Paula, additional, Santos, Moutinho, additional, Ferreira, Reis, additional, Al Ghobain, M., additional, Alorainy, H., additional, El-Hamad, E., additional, Al Hajjaj, M., additional, Hashi, A., additional, Dela, R., additional, Fanuncio, R., additional, Doloriel, E., additional, Marciano, I., additional, Safia, L., additional, Adams, Desiree, additional, Barnes, Edward, additional, Freeman, Jasper, additional, Hayes, Anton, additional, Hlengwa, Sipho, additional, Johannisen, Christine, additional, Koopman, Mariana, additional, Louw, Innocentia, additional, Ludick, Ina, additional, Olckers, Alta, additional, Ryck, Johanna, additional, Storbeck, Janita, additional, Wickremasinghe, Rajitha, additional, Elsadig, Hana A., additional, Osman, Nada Bakery, additional, Noory, Bandar Salah, additional, Mohamed, Monjda Awad, additional, Osman, Hasab Alrasoul Akasha Ahmed, additional, ed Elhassan, Namarig Moham, additional, Mu‘is El Zain, Abdel, additional, Mohamaden, Marwa Mohamed, additional, Khalifa, Suhaiba, additional, Elhadi, Mahmoud, additional, Hassan, Mohand, additional, Abdelmonam, Dalia, additional, Olafsdottir, Inga Sif, additional, Nisser, Katarina, additional, Spetz-Nyström, Ulrike, additional, Hägg, Gunilla, additional, Lund, Gun-Marie, additional, Seemungal, Terence, additional, Lutchmansingh, Fallon, additional, Conyette, Liane, additional, Denguezli, Myriam, additional, Tabka, Zouhair, additional, Daldoul, Hager, additional, Boukheroufa, Zaki, additional, Chouikha, Firas, additional, Khalifa, Wahbi Belhaj, additional, Hancioglu, Attila, additional, Hanta, Ismail, additional, Kuleci, Sedat, additional, Turkyilmaz, Ahmet Sinan, additional, Umut, Sema, additional, Unalan, Turgay, additional, Burney, Peter G. J., additional, Azar, Hadia, additional, Amor, Caron, additional, Potts, James, additional, Tumilty, Michael, additional, McLean, Fiona, additional, Dudhaiya, Risha, additional, McBurnie, Mary Ann, additional, Gillespie, Suzanne, additional, Sullivan, Sean, additional, Lee, Todd A., additional, Weiss, Kevin B., additional, Jensen, Robert L., additional, Crapo, Robert, additional, Cain, John, additional, Copeland, Rebecca, additional, Hazen, Dana, additional, and Methvin, Jennifer, additional

Published
2021
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9. Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study

Author

Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M., Bárbara, Cristina, Wouters, Emiel F. M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A., Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C., Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., Buist, A. Sonia, Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M., Bárbara, Cristina, Wouters, Emiel F. M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A., Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C., Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., and Buist, A. Sonia

Abstract

Rationale: The Global Burden of Disease program identified smoking and ambient and household air pollution as the main drivers of death and disability from chronic obstructive pulmonary disease (COPD). Objectives: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged ≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a postbronchodilator FEV1-to-FVC ratio less than the lower limit of normal, and the relative risks associated with different risk factors. Local relative risks were estimated using a Bayesian hierarchical model borrowing information from across sites. From these relative risks and the prevalence of risk factors, we estimated local population attributable risks. Measurements and Main Results: The mean prevalence of CAO was 11.2% in men and 8.6% in women. The mean population attributable risk for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index, and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: Although smoking remains the most important risk factor for CAO, in some areas, poor education, low body mass index, and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.

Published
2021
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10. Chronic airflow obstruction and ambient particulate air pollution

Author

Amaral, Andre F. S., Burney, Peter G. J., Patel, Jaymini, Minelli, Cosetta, Mejza, Filip, Mannino, David M., Seemungal, Terence A. R., Mahesh, Padukudru Anand, Lo, Li Cher, Janson, Christer, Juvekar, Sanjay, Denguezli, Meriam, Harrabi, Imed, Wouters, Emiel F. M., Cherkaski, Hamid, Mortimer, Kevin, Jogi, Rain, Bateman, Eric D., Fuertes, Elaine, Al Ghobain, Mohammed, Tan, Wan, Obaseki, Daniel O., El Sony, Asma, Studnicka, Michael, Aquart-Stewart, Althea, Koul, Parvaiz, Lawin, Herve, Nafees, Asaad Ahmed, Awopeju, Olayemi, Erhabor, Gregory E., Gislason, Thorarinn, Welte, Tobias, Gulsvik, Amund, Nielsen, Rune, Gnatiuc, Louisa, Kocabas, Ali, Marks, Guy B., Sooronbaev, Talant, Mbatchou Ngahane, Bertrand Hugo, Barbara, Cristina, Buist, A. Sonia, Amaral, Andre F. S., Burney, Peter G. J., Patel, Jaymini, Minelli, Cosetta, Mejza, Filip, Mannino, David M., Seemungal, Terence A. R., Mahesh, Padukudru Anand, Lo, Li Cher, Janson, Christer, Juvekar, Sanjay, Denguezli, Meriam, Harrabi, Imed, Wouters, Emiel F. M., Cherkaski, Hamid, Mortimer, Kevin, Jogi, Rain, Bateman, Eric D., Fuertes, Elaine, Al Ghobain, Mohammed, Tan, Wan, Obaseki, Daniel O., El Sony, Asma, Studnicka, Michael, Aquart-Stewart, Althea, Koul, Parvaiz, Lawin, Herve, Nafees, Asaad Ahmed, Awopeju, Olayemi, Erhabor, Gregory E., Gislason, Thorarinn, Welte, Tobias, Gulsvik, Amund, Nielsen, Rune, Gnatiuc, Louisa, Kocabas, Ali, Marks, Guy B., Sooronbaev, Talant, Mbatchou Ngahane, Bertrand Hugo, Barbara, Cristina, and Buist, A. Sonia

Abstract

Smoking is the most well-established cause of chronic airflow obstruction (CAO) but particulate air pollution and poverty have also been implicated. We regressed sex-specific prevalence of CAO from 41 Burden of Obstructive Lung Disease study sites against smoking prevalence from the same study, the gross national income per capita and the local annual mean level of ambient particulate matter (PM2.5) using negative binomial regression. The prevalence of CAO was not independently associated with PM2.5 but was strongly associated with smoking and was also associated with poverty. Strengthening tobacco control and improved understanding of the link between CAO and poverty should be prioritised.

Published
2021
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12. Chronic airflow obstruction and ambient particulate air pollution

Author

Amaral, Andre F S, primary, Burney, Peter G J, additional, Patel, Jaymini, additional, Minelli, Cosetta, additional, Mejza, Filip, additional, Mannino, David M, additional, Seemungal, Terence A R, additional, Mahesh, Padukudru Anand, additional, Lo, Li Cher, additional, Janson, Christer, additional, Juvekar, Sanjay, additional, Denguezli, Meriam, additional, Harrabi, Imed, additional, Wouters, Emiel F M, additional, Cherkaski, Hamid, additional, Mortimer, Kevin, additional, Jogi, Rain, additional, Bateman, Eric D, additional, Fuertes, Elaine, additional, Al Ghobain, Mohammed, additional, Tan, Wan, additional, Obaseki, Daniel O, additional, El Sony, Asma, additional, Studnicka, Michael, additional, Aquart-Stewart, Althea, additional, Koul, Parvaiz, additional, Lawin, Herve, additional, Nafees, Asaad Ahmed, additional, Awopeju, Olayemi, additional, Erhabor, Gregory E, additional, Gislason, Thorarinn, additional, Welte, Tobias, additional, Gulsvik, Amund, additional, Nielsen, Rune, additional, Gnatiuc, Louisa, additional, Kocabas, Ali, additional, Marks, Guy B, additional, Sooronbaev, Talant, additional, Mbatchou Ngahane, Bertrand Hugo, additional, Barbara, Cristina, additional, and Buist, A Sonia, additional

Published
2021
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13. Abdominal and gluteo-femoral markers of adiposity and risk of vascular-metabolic mortality in a prospective study of 150 000 Mexican adults

Author

Gnatiuc, Louisa, primary, Tapia-Conyer, Roberto, additional, Wade, Rachel, additional, Ramirez-Reyes, Raúl, additional, Aguilar-Ramirez, Diego, additional, Herrington, William, additional, Hill, Michael, additional, Lewington, Sarah, additional, Torres, Jason, additional, Trichia, Eirini, additional, Collins, Rory, additional, Peto, Richard, additional, Clarke, Robert, additional, Kuri-Morales, Pablo, additional, Emberson, Jonathan R, additional, and Alegre-Díaz, Jesus, additional

Published
2021
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14. Low-intensity daily smoking and cause-specific mortality in Mexico: prospective study of 150 000 adults

Author

Thomson, Blake, primary, Tapia-Conyer, Roberto, additional, Lacey, Ben, additional, Lewington, Sarah, additional, Ramirez-Reyes, Raúl, additional, Aguilar-Ramirez, Diego, additional, Gnatiuc, Louisa, additional, Herrington, William G, additional, Torres, Jason, additional, Trichia, Eirini, additional, Wade, Rachel, additional, Collins, Rory, additional, Peto, Richard, additional, Kuri-Morales, Pablo, additional, Alegre-Díaz, Jesus, additional, and Emberson, Jonathan R, additional

Published
2021
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15. Changes in the Diagnosis and Management of Diabetes in Mexico City Between 1998–2004 and 2015–2019

Author

Aguilar-Ramirez, Diego, primary, Alegre-Díaz, Jesus, primary, Gnatiuc, Louisa, primary, Ramirez-Reyes, Raúl, primary, Wade, Rachel, primary, Hill, Michael, primary, Collins, Rory, primary, Peto, Richard, primary, Emberson, Jonathan R, primary, Herrington, William G, primary, Kuri-Morales, Pablo, primary, and Tapia-Conyer, Roberto, primary

Published
2021
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17. Association of Blood Pressure With Cause-Specific Mortality in Mexican Adults

Author

Tapia-Conyer, Roberto, primary, Alegre-Díaz, Jesus, additional, Gnatiuc, Louisa, additional, Wade, Rachel, additional, Ramirez-Reyes, Raúl, additional, Herrington, William G., additional, Lewington, Sarah, additional, Clarke, Robert, additional, Collins, Rory, additional, Peto, Richard, additional, Kuri-Morales, Pablo, additional, and Emberson, Jonathan, additional

Published
2020
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18. Testing bronchodilator responsiveness

Author

Janson, Christer, primary, Malinovschi, Andrei, additional, Amaral, Andre F.S., additional, Accordini, Simone, additional, Bousquet, Jean, additional, Buist, A. Sonia, additional, Garcia-Aymerich, Judith, additional, Gnatiuc, Louisa, additional, Tan, Wan, additional, Torén, Kjell, additional, Zuberbier, Torsten, additional, and Burney, Peter, additional

Published
2019
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19. Bronchodilator reversibility in asthma and COPD: Findings from three large population studies

Author

Janson, Christer, Malinovschi, Andrei, Amaral, Andre, Accordini, Simone, Bousquet, Jean, Buist, A Sonia, Canonica, Giorgio Walter, Dahlén, Barbro, Garcia-Aymerich, Judith, Gnatiuc, Louisa, Kowalski, Marek, Patel, Jaymini, Tan, Wan, Torén, Kjell, Zuberbier, Torsten, Burney, Peter, Jarvis, Deborah, Amaral, Andre F.S., Buist, A. Sonia, Commission of the European Communities, Wellcome Trust, Medical Research Council (MRC), Kaiser Foundation Hospitals,Center for Health Research, Sociedade Portuguesa de Pneumologia, Tartu University Hospital, Ciro Horn, Department of Medical Sciences, Respiratory Medicine & Allergology, Uppsala University, Population Health and Occupational Disease [Londres, Royaume-Uni], National Heart and Lung Institute [Londres, Royaume-Uni] (NHLI), Imperial College London-Imperial College London, Department of Diagnostics and Public Health [Verona] (UNIVR | DDSP), University of Verona (UNIVR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], University of British Columbia (UBC), Sahlgrenska Academy at University of Gothenburg, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), and Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

Subjects
Male, Internationality, Respiratory System, ECRHS, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, RESPONSIVENESS, Pulmonary Disease, Chronic Obstructive, FEV1, 0302 clinical medicine, Forced Expiratory Volume, Bronchodilator, 030212 general & internal medicine, 11 Medical and Health Sciences, Aged, 80 and over, COPD, education.field_of_study, medicine.diagnostic_test, Middle Aged, respiratory system, Bronchodilator Agents, 3. Good health, TIME, LUNG-FUNCTION, Female, medicine.symptom, Life Sciences & Biomedicine, Adult, Pulmonary and Respiratory Medicine, Spirometry, medicine.medical_specialty, Adolescent, medicine.drug_class, prevalence, Population, GA2LEN, Young Adult, 03 medical and health sciences, FEV1/FVC ratio, Internal medicine, Wheeze, Administration, Inhalation, NITRIC-OXIDE LEVELS, medicine, Humans, Albuterol, VALIDITY, education, Aged, Asthma, Science & Technology, business.industry, asthma, BOLD, bronchodilator reversibility, COPD, ECRHS, GA2LEN, prevalence, asthma, medicine.disease, FVC, respiratory tract diseases, bronchodilator reversibility, Logistic Models, 030228 respiratory system, Multivariate Analysis, Exhaled nitric oxide, OBSTRUCTION, business, BOLD
Abstract

Bronchodilator response (BDR) testing is used as a diagnostic method in obstructive airway diseases. The aim of this investigation was to compare different methods for measuring BDR in participants with asthma and chronic obstructive pulmonary disease (COPD) and to study to the extent to which BDR was related to symptom burden and phenotypic characteristics.Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured before and 15 min after 200 μg of salbutamol in 35 628 subjects aged ≥16 years from three large international population studies. The subjects were categorised in three groups: current asthma (n=2833), COPD (n=1146) and no airway disease (n=31 649). Three definitions for flow-related reversibility (increase in FEV1) and three for volume-related reversibility (increase in FVC) were used.The prevalence of bronchodilator reversibility expressed as increase FEV1 ≥12% and 200 mL was 17.3% and 18.4% in participants with asthma and COPD, respectively, while the corresponding prevalence was 5.1% in those with no airway disease. In asthma, bronchodilator reversibility was associated with wheeze (OR 1.36, 95% CI 1.04–1.79), atopy (OR 1.36, 95% CI 1.04–1.79) and higher exhaled nitric oxide fraction, while in COPD neither flow- nor volume-related bronchodilator reversibility was associated with symptom burden, exacerbations or health status after adjusting for pre-bronchodilator FEV1.Bronchodilator reversibility was at least as common in participants with COPD as those with asthma. This indicates that measures of reversibility are of limited value for distinguishing asthma from COPD in population studies. However, in asthma, bronchodilator reversibility may be a phenotypic marker.

Published
2019

20. Testing bronchodilator responsiveness

Author

Janson, Christer, Malinovschi, Andrei, Amaral, Andre F. S., Accordini, Simone, Bousquet, Jean, Buist, A. Sonia, Garcia-Aymerich, Judith, Gnatiuc, Louisa, Tan, Wan, Toren, Kjell, Zuberbier, Torsten, Burney, Peter, Janson, Christer, Malinovschi, Andrei, Amaral, Andre F. S., Accordini, Simone, Bousquet, Jean, Buist, A. Sonia, Garcia-Aymerich, Judith, Gnatiuc, Louisa, Tan, Wan, Toren, Kjell, Zuberbier, Torsten, and Burney, Peter

Published
2019
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21. Testing bronchodilator responsiveness

Author

Jansson, Christer, Malinovschi, Andrei, Amaral, Andre F. S., Accordini, Simone, Bousquet, Jean, Buist, A. Sonia, Garcia-Aymerich, Judith, Gnatiuc, Louisa, Tan, Wan, Toren, Kjell, Zuberbier, Torsten, Burney, Peter, Jansson, Christer, Malinovschi, Andrei, Amaral, Andre F. S., Accordini, Simone, Bousquet, Jean, Buist, A. Sonia, Garcia-Aymerich, Judith, Gnatiuc, Louisa, Tan, Wan, Toren, Kjell, Zuberbier, Torsten, and Burney, Peter

Published
2019
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22. Bronchodilator reversibility in asthma and COPD : findings from three large population studies

Author

Jansson, Christer, Malinovschi, Andrei, Amaral, Andre F. S., Accordini, Simone, Bousquet, Jean, Buist, A. Sonia, Canonica, Giorgio Walter, Dahlen, Barbro, Garcia-Aymerich, Judith, Gnatiuc, Louisa, Kowalski, Marek L., Patel, Jaymini, Tan, Wan, Toren, Kjell, Zuberbier, Torsten, Burney, Peter, Jarvis, Deborah, Jansson, Christer, Malinovschi, Andrei, Amaral, Andre F. S., Accordini, Simone, Bousquet, Jean, Buist, A. Sonia, Canonica, Giorgio Walter, Dahlen, Barbro, Garcia-Aymerich, Judith, Gnatiuc, Louisa, Kowalski, Marek L., Patel, Jaymini, Tan, Wan, Toren, Kjell, Zuberbier, Torsten, Burney, Peter, and Jarvis, Deborah

Abstract

Bronchodilator response (BDR) testing is used as a diagnostic method in obstructive airway diseases. The aim of this investigation was to compare different methods for measuring BDR in participants with asthma and chronic obstructive pulmonary disease (COPD) and to study to the extent to which BDR was related to symptom burden and phenotypic characteristics. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured before and 15 min after 200 mu g of salbutamol in 35 628 subjects aged >= 16 years from three large international population studies. The subjects were categorised in three groups: current asthma (n=2833), COPD (n=1146) and no airway disease (n=31 649). Three definitions for flow-related reversibility (increase in FEV1) and three for volume-related reversibility (increase in FVC) were used. The prevalence of bronchodilator reversibility expressed as increase FEV1 >= 12% and 200 mL was 17.3% and 18.4% in participants with asthma and COPD, respectively, while the corresponding prevalence was 5.1% in those with no airway disease. In asthma, bronchodilator reversibility was associated with wheeze (OR 1.36, 95% CI 1.04-1.79), atopy (OR 1.36, 95% CI 1.04-1.79) and higher exhaled nitric oxide fraction, while in COPD neither flow- nor volume-related bronchodilator reversibility was associated with symptom burden, exacerbations or health status after adjusting for pre-bronchodilator FEV1. Bronchodilator reversibility was at least as common in participants with COPD as those with asthma. This indicates that measures of reversibility are of limited value for distinguishing asthma from COPD in population studies. However, in asthma, bronchodilator reversibility may be a phenotypic marker.

Published
2019
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23. General and Abdominal Adiposity and Mortality in Mexico City

Author

Gnatiuc, Louisa, primary, Alegre-Díaz, Jesus, additional, Wade, Rachel, additional, Ramirez-Reyes, Raúl, additional, Tapia-Conyer, Roberto, additional, Garcilazo-Ávila, Adrián, additional, Chiquete, Erwin, additional, Gonzáles-Carballo, Carlos, additional, Solano-Sanchez, Martha, additional, Clarke, Robert, additional, Collins, Rory, additional, Herrington, William G., additional, Hill, Michael, additional, Lewington, Sarah, additional, Peto, Richard, additional, Emberson, Jonathan R., additional, and Kuri-Morales, Pablo, additional

Published
2019
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24. Changes in the Diagnosis and Management of Diabetes in Mexico City Between 1998-2004 and 2015-2019.

Author

Aguilar-Ramirez, Diego, Alegre-Díaz, Jesus, Gnatiuc, Louisa, Ramirez-Reyes, Raúl, Wade, Rachel, Hill, Michael, Collins, Rory, Peto, Richard, Emberson, Jonathan R., Herrington, William G., Kuri-Morales, Pablo, and Tapia-Conyer, Roberto

Subjects
DIAGNOSIS of diabetes, EARLY death, DIAGNOSIS
Abstract

Objective: To investigate the trends in diabetes prevalence, diagnosis, and management among Mexican adults who were participants in a long-term prospective study.Research Design and Methods: From 1998 to 2004, 159,755 adults from Mexico City were recruited to a prospective study, and from 2015 to 2019, 10,144 survivors were resurveyed. Diabetes was defined as self-reported diagnosis, glucose-lowering medication use, or HbA1c ≥6.5%. Controlled diabetes was defined as HbA1c <7%. Prevalence estimates were uniformly standardized for age, sex, and residential district. Cox models explored the relevance of controlled and inadequately controlled diabetes to cause-specific mortality.Results: During 1998-2004 and 2015-2019, 99,623 and 8,986 participants were aged 45-84 years. Diabetes prevalence had increased from 26% in 1998-2004 to 35% by 2015-2019. Of those with diabetes, the proportion previously diagnosed had increased from 76% to 89%, and glucose-lowering medication use among them had increased from 80% to 94%. Median HbA1c among those with diabetes had decreased from 8.2% to 7.3%, and the proportion of participants with controlled diabetes had increased from 16% to 37%. Use of blood pressure-lowering medication among those with previously diagnosed diabetes had increased from 35% to 51%, and their use of lipid-lowering therapy had increased from 1% to 14%. The excess mortality risk associated with diabetes accounted for 34% of deaths at ages 35-74 years, of which 5% were attributable to controlled and 29% to inadequately controlled diabetes.Conclusions: Inadequately controlled diabetes is a leading cause of premature adult death in Mexico. Improvements in diabetes management have increased diagnosis and control, but substantial opportunities remain to improve treatment, particularly with lipid-lowering therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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25. Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study

Author

Horner, Andreas; https://orcid.org/0000-0001-7746-3335, Soriano, Joan B, Puhan, Milo A, Studnicka, Michael, Kaiser, Bernhard, Vanfleteren, Lowie E G W, Gnatiuc, Louisa, Burney, Peter, Miravitlles, Marc, García-Rio, Francisco, Ancochea, Julio, Menezes, Ana M, Perez-Padilla, Rogelio, Montes de Oca, Maria, Torres-Duque, Carlos A, Caballero, Andres, González-García, Mauricio, Buist, Sonia, Flamm, Maria, Lamprecht, Bernd, Horner, Andreas; https://orcid.org/0000-0001-7746-3335, Soriano, Joan B, Puhan, Milo A, Studnicka, Michael, Kaiser, Bernhard, Vanfleteren, Lowie E G W, Gnatiuc, Louisa, Burney, Peter, Miravitlles, Marc, García-Rio, Francisco, Ancochea, Julio, Menezes, Ana M, Perez-Padilla, Rogelio, Montes de Oca, Maria, Torres-Duque, Carlos A, Caballero, Andres, González-García, Mauricio, Buist, Sonia, Flamm, Maria, and Lamprecht, Bernd

Abstract

BACKGROUND: COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. METHODS: A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. RESULTS: Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. CONCLUSION: Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD.

Published
2017

27. Adiposity and Blood Pressure in 110 000 Mexican Adults

Author

Gnatiuc, Louisa, primary, Alegre-Díaz, Jesus, additional, Halsey, Jim, additional, Herrington, William G., additional, López-Cervantes, Malaquías, additional, Lewington, Sarah, additional, Collins, Rory, additional, Tapia-Conyer, Roberto, additional, Peto, Richard, additional, Emberson, Jonathan R., additional, and Kuri-Morales, Pablo, additional

Published
2017
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28. Diabetes and Cause-Specific Mortality in Mexico City

Author

Alegre-Díaz, Jesus, primary, Herrington, William, additional, López-Cervantes, Malaquías, additional, Gnatiuc, Louisa, additional, Ramirez, Raul, additional, Hill, Michael, additional, Baigent, Colin, additional, McCarthy, Mark I., additional, Lewington, Sarah, additional, Collins, Rory, additional, Whitlock, Gary, additional, Tapia-Conyer, Roberto, additional, Peto, Richard, additional, Kuri-Morales, Pablo, additional, and Emberson, Jonathan R., additional

Published
2016
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33. Determinants of Underdiagnosis of COPD in National and International Surveys

Author

Lamprecht, Bernd, primary, Soriano, Joan B., additional, Studnicka, Michael, additional, Kaiser, Bernhard, additional, Vanfleteren, Lowie E., additional, Gnatiuc, Louisa, additional, Burney, Peter, additional, Miravitlles, Marc, additional, García-Rio, Francisco, additional, Akbari, Kaveh, additional, Ancochea, Julio, additional, Menezes, Ana M., additional, Perez-Padilla, Rogelio, additional, Montes de Oca, Maria, additional, Torres-Duque, Carlos A., additional, Caballero, Andres, additional, González-García, Mauricio, additional, and Buist, Sonia, additional

Published
2015
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34. The burden of non-communicable lung disease in urban Malawi

Author

Mortimer, Kevin, primary, Azhar, Hadia, additional, Patel, Jaymini, additional, Kapur, Sabrina, additional, Gnatiuc, Louisa, additional, Burney, Peter, additional, Davis, Kourtney, additional, Nadeau, Gilbert, additional, Nyirenda, Moffat, additional, and Gordon, Stephen, additional

Published
2015
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37. Chronic obstructive pulmonary disease mortality and prevalence : the associations with smoking and poverty-a BOLD analysis

Author

Burney, Peter, Jithoo, Anamika, Kato, Bernet, Janson, Christer, Mannino, David, Nizankowska-Mogilnicka, Ewa, Studnicka, Michael, Tan, Wan, Bateman, Eric, Kocabas, Ali, Vollmer, William M., Gislason, Thorarrin, Marks, Guy, Koul, Parvaiz A., Harrabi, Imed, Gnatiuc, Louisa, Buist, Sonia, Burney, Peter, Jithoo, Anamika, Kato, Bernet, Janson, Christer, Mannino, David, Nizankowska-Mogilnicka, Ewa, Studnicka, Michael, Tan, Wan, Bateman, Eric, Kocabas, Ali, Vollmer, William M., Gislason, Thorarrin, Marks, Guy, Koul, Parvaiz A., Harrabi, Imed, Gnatiuc, Louisa, and Buist, Sonia

Abstract

Background Chronic obstructive pulmonary disease (COPD) is a commonly reported cause of death and associated with smoking. However, COPD mortality is high in poor countries with low smoking rates. Spirometric restriction predicts mortality better than airflow obstruction, suggesting that the prevalence of restriction could explain mortality rates attributed to COPD. We have studied associations between mortality from COPD and low lung function, and between both lung function and death rates and cigarette consumption and gross national income per capita (GNI). Methods National COPD mortality rates were regressed against the prevalence of airflow obstruction and spirometric restriction in 22 Burden of Obstructive Lung Disease (BOLD) study sites and against GNI, and national smoking prevalence. The prevalence of airflow obstruction and spirometric restriction in the BOLD sites were regressed against GNI and mean pack years smoked. Results National COPD mortality rates were more strongly associated with spirometric restriction in the BOLD sites (<60 years: men r(s)=0.73, p=0.0001; women r(s)=0.90, p<0.0001; 60+ years: men r(s)=0.63, p=0.0022; women r(s)=0.37, p=0.1) than obstruction (<60 years: men r(s)=0.28, p=0.20; women r(s)=0.17, p<0.46; 60+ years: men r(s)=0.28, p=0.23; women r(s)=0.22, p=0.33). Obstruction increased with mean pack years smoked, but COPD mortality fell with increased cigarette consumption and rose rapidly as GNI fell below US$ 15 000. Prevalence of restriction was not associated with smoking but also increased rapidly as GNI fell below US$ 15 000. Conclusions Smoking remains the single most important cause of obstruction but a high prevalence of restriction associated with poverty could explain the high 'COPD' mortality in poor countries.

Published
2014
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38. Predictors of dyspnoea prevalence : results from the BOLD study

Author

Gronseth, Rune, Vollmer, William M., Hardie, Jon A., Olafsdottir, Inge Sif, Lamprecht, Bernd, Buist, A. Sonia, Gnatiuc, Louisa, Gulsvik, Amund, Johannessen, Ane, Enright, Paul, Gronseth, Rune, Vollmer, William M., Hardie, Jon A., Olafsdottir, Inge Sif, Lamprecht, Bernd, Buist, A. Sonia, Gnatiuc, Louisa, Gulsvik, Amund, Johannessen, Ane, and Enright, Paul

Abstract

Dyspnoea is a cardinal symptom for cardiorespiratory diseases. No study has assessed worldwide variation in dyspnoea prevalence or predictors of dyspnoea. We used cross-sectional data from population-based samples in 15 countries of the Burden of Obstructive Lung Disease (BOLD) study to estimate prevalence of dyspnoea in the full sample, as well as in an a priori defined low-risk group (few risk factors or dyspnoea-associated diseases). Dyspnoea was defined by the modified Medical Research Council questions. We used ordered logistic regression analysis to study the association of dyspnoea with site, sex, age, education, smoking habits, low/high body mass index, self-reported disease and spirometry results. Of the 9484 participants, 27% reported any dyspnoea. In the low-risk subsample (n = 4329), 16% reported some dyspnoea. In multivariate analyses, all covariates were correlated to dyspnoea, but only 13% of dyspnoea variation was explained. Females reported more dyspnoea than males (odds ratio similar to 2.1). When forced vital capacity fell below 60% of predicted, dyspnoea was much more likely. There was considerable geographical variation in dyspnoea, even when we adjusted for known risk factors and spirometry results. We were only able to explain 13% of dyspnoea variation.

Published
2014
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39. Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study.

Author

Horner, Andreas, Soriano, Joan B., Puhan, Milo A., Studnicka, Michael, Kaiser, Bernhard, Vanfleteren, Lowie E. G. W., Gnatiuc, Louisa, Burney, Peter, Miravitlles, Marc, García-Rio, Francisco, Ancochea, Julio, Menezes, Ana M., Perez-Padilla, Rogelio, de Oca, Maria Montes, Torres-Duque, Carlos A., Caballero, Andres, González-García, Mauricio, Buist, Sonia, Flamm, Maria, and Lamprecht, Bernd

Subjects
OBSTRUCTIVE lung diseases, BRONCHODILATOR agents, AIR pollution, SYMPTOMS, RESPIRATORY disease diagnosis, OBSTRUCTIVE lung disease diagnosis, ALTITUDES, STATISTICAL sampling, SPIROMETRY, DISEASE prevalence, VITAL capacity (Respiration)
Abstract

Background: COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors.Methods: A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD.Results: Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude.Conclusion: Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. [ABSTRACT FROM AUTHOR]

Published
2017
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40. Sex-related differences in respiratory symptoms : results from the BOLD Study

Author

Lamprecht, Bernd, Vanfleteren, Lowie E., Studnicka, Michael, Allison, Michael, McBurnie, Mary Ann, Vollmer, William M., Tan, Wan Cheng, Nielsen, Rune, Nastalek, Pawel, Gnatiuc, Louisa, Kaiser, Bernhard, Janson, Christer, Wouters, Emiel F. M., Burney, Peter, Buist, A. Sonia, Lamprecht, Bernd, Vanfleteren, Lowie E., Studnicka, Michael, Allison, Michael, McBurnie, Mary Ann, Vollmer, William M., Tan, Wan Cheng, Nielsen, Rune, Nastalek, Pawel, Gnatiuc, Louisa, Kaiser, Bernhard, Janson, Christer, Wouters, Emiel F. M., Burney, Peter, and Buist, A. Sonia

Published
2013
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41. The impact of COPD on health status : findings from the BOLD study

Author

Janson, Christer, Marks, Guy, Buist, Sonia, Gnatiuc, Louisa, Gislason, Thorarinn, McBurnie, Mary Ann, Nielsen, Rune, Studnicka, Michael, Toelle, Brett, Benediktsdottir, Bryndis, Burney, Peter, Janson, Christer, Marks, Guy, Buist, Sonia, Gnatiuc, Louisa, Gislason, Thorarinn, McBurnie, Mary Ann, Nielsen, Rune, Studnicka, Michael, Toelle, Brett, Benediktsdottir, Bryndis, and Burney, Peter

Abstract

The aim of this study was to describe the impact of chronic obstructive pulmonary disease (COPD) on health status in the Burden of Obstructive Lung Disease (BOLD) populations. We conducted a cross-sectional, general population-based survey in 11 985 subjects from 17 countries. We measured spirometric lung function and assessed health status using the Short Form 12 questionnaire. The physical and mental health component scores were calculated. Subjects with COPD (post-bronchodilator forced expiratory volume in 1 s/forced vital capacity <0.70, n=2269) had lower physical component scores (44 +/- 10 versus 48 +/- 10 units, p<0.0001) and mental health component scores (51 +/- 10 versus 52 +/- 10 units, p=0.005) than subjects without COPD. The effect of reported heart disease, hypertension and diabetes on physical health component scores (-3 to -4 units) was considerably less than the effect of COPD Global Initiative for Chronic Obstructive Lung Disease grade 3 (-8 units) or 4 (-11 units). Dyspnoea was the most important determinant of a low physical and mental health component scores. In addition, lower forced expiratory volume in 1 s, chronic cough, chronic phlegm and the presence of comorbidities were all associated with a lower physical health component score. COPD is associated with poorer health status but the effect is stronger on the physical than the mental aspects of health status. Severe COPD has a greater negative impact on health status than self-reported cardiovascular disease and diabetes.

Published
2013
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43. Sex-related differences in respiratory symptoms: results from the BOLD Study

Author

Lamprecht, Bernd, primary, Vanfleteren, Lowie E., additional, Studnicka, Michael, additional, Allison, Michael, additional, McBurnie, Mary Ann, additional, Vollmer, William M., additional, Tan, Wan Cheng, additional, Nielsen, Rune, additional, Nastalek, Pawel, additional, Gnatiuc, Louisa, additional, Kaiser, Bernhard, additional, Janson, Christer, additional, Wouters, Emiel F.M., additional, Burney, Peter, additional, and Buist, A. Sonia, additional

Published
2013
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45. The impact of COPD on health status: findings from the BOLD study

Author

Janson, Christer, primary, Marks, Guy, additional, Buist, Sonia, additional, Gnatiuc, Louisa, additional, Gislason, Thorarinn, additional, McBurnie, Mary Ann, additional, Nielsen, Rune, additional, Studnicka, Michael, additional, Toelle, Brett, additional, Benediktsdottir, Bryndis, additional, and Burney, Peter, additional

Published
2013
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47. Chronic Airflow Obstruction in a Black African Population: Results of BOLD Study, Ile-Ife, Nigeria.

Author

Obaseki, Daniel O., Erhabor, Gregory E., Gnatiuc, Louisa, Adewole, Olufemi O., Buist, Sonia A., and Burney, Peter G.

Subjects
OBSTRUCTIVE lung diseases patients, OBSTRUCTIVE lung diseases, CAUSES of death, RESPIRATORY diseases, CHRONIC bronchitis, DISEASE risk factors
Abstract

Global estimates suggest that Chronic Obstructive Pulmonary Disease (COPD) is emerging as a leading cause of death in developing countries but there are few spirometry-based general population data on its prevalence and risk factors in sub-Saharan Africa. We used the Burden of Obstructive Lung Disease (BOLD) protocol to select a representative sample of adults aged 40 years and above in Ile-Ife, Nigeria. All the participants underwent spirometry and provided information on smoking history, biomass and occupational exposures as well as diagnosed respiratory diseases and symptoms. Chronic Airflow Obstruction (CAO) was defined as the ratio of post-bronchodilator (BD) one second Forced Expiratory Volume (FEV1) to Forced Vital Capacity (FVC) below the lower limit of normal (LLN) of the population distribution for FEV1/FVC. The overall prevalence of obstruction (post-BD FEV1/FVC < LLN) was 7.7% (2.7% above LLN) using Global Lung Function Initiative (GLI) equations. It was associated with few respiratory symptoms; 0.3% reported a previous doctor-diagnosed chronic bronchitis, emphysema or COPD. Independent predictors included a lack of education (OR 2-5, 95% Cl; 1.0, 6.4) and a diagnosis of either TB (OR 23.4, 95% Cl: 2.0, 278.6) or asthma (OR 35.4, 95%CI: 4.9, 255.8). There was no association with the use of firewood or coal for cooking or heating. The vast majority of this population (89%) are never smokers. We conclude that the prevalence of CAO is low in Ile-Ife, Nigeria and unrelated to biomass exposure. The key independent predictors are poor education, and previous diagnosis of tuberculosis or asthma. [ABSTRACT FROM AUTHOR]

Published
2016
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49. Prevalence and Population Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study

Author

Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M, Bárbara, Cristina, Wouters, Emiel F.M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A, Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C, Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., Buist, A. Sonia, Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M, Bárbara, Cristina, Wouters, Emiel F.M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A, Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C, Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., and Buist, A. Sonia

Abstract

Rationale: The Global Burden of Disease programme identified smoking, and ambient and household air pollution as the main drivers of death and disability from Chronic Obstructive Pulmonary Disease (COPD). Objective: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a post-bronchodilator one-second forced expiratory volume to forced vital capacity ratio < lower limit of normal, and the relative risks associated with different risk factors. Local RR were estimated using a Bayesian hierarchical model borrowing information from across sites. From these RR and the prevalence of risk factors, we estimated local Population Attributable Risks (PAR). Measurements and Main Results: Mean prevalence of CAO was 11.2% in men and 8.6% in women. Mean PAR for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index (BMI), and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: While smoking remains the most important risk factor for CAO, in some areas poor education, low BMI and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.

50. Prevalence and Population Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study

Author

Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M, Bárbara, Cristina, Wouters, Emiel F.M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A, Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C, Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., Buist, A. Sonia, Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M, Bárbara, Cristina, Wouters, Emiel F.M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A, Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C, Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., and Buist, A. Sonia

Abstract

Rationale: The Global Burden of Disease programme identified smoking, and ambient and household air pollution as the main drivers of death and disability from Chronic Obstructive Pulmonary Disease (COPD). Objective: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a post-bronchodilator one-second forced expiratory volume to forced vital capacity ratio < lower limit of normal, and the relative risks associated with different risk factors. Local RR were estimated using a Bayesian hierarchical model borrowing information from across sites. From these RR and the prevalence of risk factors, we estimated local Population Attributable Risks (PAR). Measurements and Main Results: Mean prevalence of CAO was 11.2% in men and 8.6% in women. Mean PAR for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index (BMI), and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: While smoking remains the most important risk factor for CAO, in some areas poor education, low BMI and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.

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