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186 results on '"Gnarpe, Judy"'

7. Helicobacter pylori serology in elderly people: a 21-year cohort comparison in 70-year-olds and a 20-year longitudinal population study in 70-90-year-olds

Author

Gnarpe, Hakan, Gnarpe, Judy, Lundborg, Per, and Steen, Bertil

Subjects
Aged -- Diseases, Helicobacter pylori -- Development and progression, Health, Psychology and mental health, Seniors, Social sciences, Diseases, Development and progression
Abstract

Introduction Since the first successful culture of spiral bacteria from the human stomach in 1982 [1], Helicobacter pylori has been increasingly recognized to be one of the most common bacterial [...]

Published
1998

25. Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study

Author

Chernesky Max, Mahony Jim, Goldsmith Charlie H, Molloy William, Smieja Marek, Chan Carusone Soo, Gnarpe Judy, Standish Tim, Smith Stephanie, and Loeb Mark

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Chronic inflammation appears to play a role in the pathogenesis of vascular dementia. Given the association between Chlamydia pneumoniae and stroke, the possibility exists that previous exposure to C. pneumoniae may play a role in vascular dementia. The objective of this study was to determine if there was an association between serological evidence of C. pneumoniae infection or inflammatory markers with vascular dementia. Methods 28 case-patients with vascular dementia at a geriatric clinic and 24 caregiver-controls were tested for C. pneumoniae IgG and IgA antibodies. The association between vascular dementia and C. pneumoniae titres as well as inflammatory markers was estimated by using both conditional logistic regression and stratified logistic regression. Results When matched cases were compared to controls, there was no significant difference in elevated C. pneumoniae specific IgG antibodies (titre ≥ 1:32), odds ratio [OR] 1.3 (95% confidence intervals [CI] 0.3 to 6.0), p = 0.71, or in elevated C. pneumoniae specific IgA antibodies (titre ≥ 1:16), OR 2.0 (95%CI 0.5 to 8.0), p = 0.33 indicative of past or persistent C. pneumoniae infection. Similarly, no difference in high IgG or IgA antibody levels (IgG titre ≥ 1:512 or IgA titre ≥ 1:64) between the two groups, indicative of recent C. pneumoniae infection, was found, OR 0.4 (95%CI 0.1 to 2.1), p = 0.27. For C-reactive protein (CRP), the mean difference between 18 matched pairs (case – control) was – 3.33 mg/L. There was no significant difference between cases and controls when comparing log transformed values, OR 0.03 (95%CI 0.00 to 2.89), p = 0.13 or comparing CRP values above or below the median, OR 0.8 (95%CI 0.2 to 3.4), p = 0.71. For fibrinogen, the mean difference between pairs (case – control) was -0.07 g/L. There was no statistical difference between cases and controls when comparing log transformed values, OR 0.6 (95%CI 0.0 to 31.2), p = 0.79 or between fibrinogen values above and below the median, OR = 0.5 (95%CI 0.1 to 2.0), p = 0.50. Conclusion We found no evidence for a significant association between C. pneumoniae infection, inflammatory markers such as CRP and fibrinogen, and vascular dementia.

Published
2004
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27. Detection of Chlamydia pneumoniae on cytospin preparations from bronchoalveolar lavage in COPD patients and in lung tissue from advanced emphysema

Author

Brandén, Eva, Gnarpe, Judy, Hillerdal, Gunnar, Orre, Lotta, Sköld, C Magnus, Löfdahl, Magnus, Koyi, Hirsh, and Tornling, Göran

Subjects
lung tissue, Male, Sweden, Cytodiagnosis, cytospin, respiratory system, Chlamydophila pneumoniae, Middle Aged, Bronchoalveolar Lavage, respiratory tract diseases, Respiratory Function Tests, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Chlamydia pneumoniae, COPD, Humans, Female, Lung, Original Research
Abstract

Chronic obstructive pulmonary disease (COPD) is associated with smoking but other etiological factors contribute. Chlamydia pneumoniae is an obligate intracellular bacterium causing both acute and chronic respiratory tract infections. Studies have revealed an association between chronic C. pneumoniae infection and COPD, asthma and lung cancer but there have been difficulties detecting C. pneumoniae in the bronchial tree. Cytospin slides prepared from bronchoalveolar lavage (BAL) fluid from 14 patients with COPD, 10 healthy smokers (S) and 7 non smokers (NS) were analyzed with a fluorescein isothiocyanate labeled monoclonal antibody to C. pneumoniae. Lung tissue from 24 patients with advanced emphysema who had undergone lung volume reduction surgery (LVRS) was examined with immunohistochemistry for C. pneumoniae. Archived serum samples for detection of specific C. pneumoniae antibodies by microimmunofluorescence were available for 30 of the BAL subjects and 11 of LVRS patients. C. pneumoniae elementary body like structures were found in 29% of cytospin specimens from COPD patients, 14% of NS and 10% of HS. C. pneumoniae was detected in lung tissue in 8%. COPD patients had higher titres of IgG and IgA than NS and S. There was no association between occurrence of C. pneumoniae in BAL fluid and antibody titres. In conclusion, the assays used for detection of C. pneumoniae in lung tissue are feasible, and could be adapted in adequately powered studies to further confirm an association between C. pneumoniae infection and COPD.

Published
2007

34. Antibodies to Chlamydia pneumoniae in young Swedish orienteers

Author

Hjelm, Eva, Wesslén, Lars, Gnarpe, Håkan, Gnarpe, Judy, Nyström-Rosander, Christina, Rolf, Christer, Friman, Göran, Hjelm, Eva, Wesslén, Lars, Gnarpe, Håkan, Gnarpe, Judy, Nyström-Rosander, Christina, Rolf, Christer, and Friman, Göran

Abstract

During 1992-93 sera from 1790 Swedish elite orienteers were tested for antibodies to Chlamydia pneumoniae. The reason for this was that a cluster of 16 cases of sudden unexpected cardiac death had occurred among Swedish orienteers and DNA from C. pneumoniae had been found in the myocarditic heart and in the lung in 1 of 2 deceased athletes in whom testing was feasible; in addition, C. pneumoniae IgG was found in all 5 cases where serum was available. Among the orienteers, the prevalence rates of IgG antibodies in males and females were 54% (n = 1194) and 50% (n = 596), respectively. The corresponding figures for 319 male and female blood donors were 60% (n = 169) and 53% (n = 150), respectively. These differences are not statistically significant. Male orienteers had a lower prevalence of IgA antibodies than male blood donors (19% and 26%, respectively; p < 0.05), while no such difference was found in females (16% and 18%). The prevalence of IgM antibodies was < 1% in all groups. Neither the performance level of the orienteers nor the place of residence affected the antibody prevalence. In conclusion, Swedish orienteers do not show a higher prevalence of antibodies to C. pneumoniae than healthy blood donors.

Published
2001

35. Chlamydia pneumoniae in children undergoing adenoidectomy

Author

Normann, Erik, Gnarpe, Judy, Nääs, Jessica, Gnarpe, Håkan, Karlsson, Mats G, Wettergren, Björn, Normann, Erik, Gnarpe, Judy, Nääs, Jessica, Gnarpe, Håkan, Karlsson, Mats G, and Wettergren, Björn

Published
2001

41. Relationship of Anti-60 kDa Heat Shock Protein and Anti-Cholesterol Antibodies to Cardiovascular Events

Author

Veres, Amarilla, primary, Füst, George, additional, Smieja, Marek, additional, McQueen, Matthew, additional, Horváth, Anna, additional, Yi, Qilong, additional, Bíró, Adrienn, additional, Pogue, Janice, additional, Romics, László, additional, Karádi, István, additional, Singh, Mahavir, additional, Gnarpe, Judy, additional, Prohászka, Zoltán, additional, and Yusuf, Salim, additional

Published
2002
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42. Chlamydia pneumoniaeSerology: Interlaboratory Variation in Microimmunofluorescence Assay Results

Author

Peeling, Rosanna W., primary, Wang, San‐Pin, additional, Grayston, J. Thomas, additional, Blasi, Francesco, additional, Boman, Jens, additional, Clad, Andreas, additional, Freidank, Heike, additional, Gaydos, Charlotte A., additional, Gnarpe, Judy, additional, Hagiwara, Toshikatsu, additional, Jones, Robert B., additional, Orfila, Jeanne, additional, Persson, Kenneth, additional, Puolakkainen, Mirja, additional, Saikku, Pekka, additional, and Schachter, Julius, additional

Published
2000
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