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24 results on '"Gmouh, Saïd"'

5. Characterization of the Inclusion of Polymer Membrane for Application as Electrolyte in Direct Methanol Fuel Cell System

Author

Aghmih, Kaoutar, Touarssi, Imane, Gmouh, Said, Hlaïbi, Miloudi, Majid, Sanaa, Förstner, Ulrich, Series Editor, Rulkens, Wim H., Series Editor, Salomons, Wim, Series Editor, Ksibi, Mohamed, editor, Ghorbal, Achraf, editor, Chakraborty, Sudip, editor, Chaminé, Helder I., editor, Barbieri, Maurizio, editor, Guerriero, Giulia, editor, Hentati, Olfa, editor, Negm, Abdelazim, editor, Lehmann, Anthony, editor, Römbke, Jörg, editor, Costa Duarte, Armando, editor, Xoplaki, Elena, editor, Khélifi, Nabil, editor, Colinet, Gilles, editor, Miguel Dias, João, editor, Gargouri, Imed, editor, Van Hullebusch, Eric D., editor, Sánchez Cabrero, Benigno, editor, Ferlisi, Settimio, editor, Tizaoui, Chedly, editor, Kallel, Amjad, editor, Rtimi, Sami, editor, Panda, Sandeep, editor, Michaud, Philippe, editor, Sahu, Jaya Narayana, editor, Seffen, Mongi, editor, and Naddeo, Vincenzo, editor

Published
2021
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16. List of contributors

Author

Ahmed, Hanan B., Akca, Candan, Ali, S. Wazed, Aly, Nermin M., Angelova, Radostina A., Appoloni, Carlos Roberto, Azarniya, Amir, Bahtiyari, Muhammed İbrahim, Bairagi, Satyaranjan, Banerjee, Sourav, Banerjee, Swagata, Bili, Oumaima, Boukhriss, Aicha, Chandran, Achu, de Dio Ferreira, Diego, El Kalaaoui, Khadija, Emam, Hossam E., Farooq, Umar, Galvão, Tiago Dutra, Gmouh, Said, Gürgen, Selim, Hamouda, Tamer, Kangazi, Mahsa Kangazian, Kaplan, Sibel, Kashyap, Preety Kumari, Kordani, Naser, Korkmaz Memiş, Nazife, Körlü, Ayşegül, Kuşhan, Melih Cemal, Madhu, Amit, Merati, Ali Akbar, Motlagh, Mohammad Bagheri, Naik, S.N., Nisar, Safiya, Pandit, Ashiq Hussain, Peethambharan, Surendran Kuzhichalil, Pillai, Adarsh Sivan, Sheikhi, Mohammad Rauf, Singh, Nagender, Ul-Islam, Shahid, and Venkatraman, Prabhuraj D.

Published
2023
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17. Tomentosin Induces Telomere Shortening and Caspase-Dependant Apoptosis in Cervical Cancer Cells

Author

Merghoub, Nawel, El Btaouri, Hassan, Benbacer, Laila, Gmouh, Saïd, Trentesaux, Chantal, Brassart, Bertrand, Attaleb, Mohammed, Madoulet, Claudie, Wenner, Thomas, Amzazi, Saaïd, Morjani, Hamid, El Mzibri, Mohamed, Biology and Mediacl Research Unit, Centre National de l'Energie, des Sciences et Techniques Nucléaires, EA2063 - biochimie et biologie moléculaire, Université de Reims Champagne-Ardenne (URCA), Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Faculté des sciences [Rabat], Université Mohammed V de Rabat [Agdal], Centre National de l’Energie, des Sciences et des Techniques Nucléaires (CNE ), Volubilis AI n° MA/07/178 - Egide n° 13466WE, and 2007-2010, 'Comité Mixte Inter-universitaire Franco-Marocain'

Subjects
G2 Phase, Membrane Potential, Mitochondrial, TELOMERE SHORTENING, Caspase 3, Blotting, Western, Uterine Cervical Neoplasms, Cell Cycle Checkpoints, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Telomere, CERVICAL CANCER, APOPTOSIS, Lactones, TOMENTOSIN, Cell Line, Tumor, Humans, Female, CYTOTOXICITY, Reactive Oxygen Species, Sesquiterpenes, Cell Division, ComputingMilieux_MISCELLANEOUS, Cell Proliferation, HeLa Cells
Abstract

Tomentosin, a natural sesquiterpene lactone purified from of Inula viscosa L., was investigated for its anti-proliferative, telomere shortening, and apoptotic effects on human cervical cancer HeLa and SiHa cell lines. Tomentosin was found to inhibit the growth of SiHa and HeLa cell lines in dose and time-dependent manner (IC

Published
2017
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18. List of contributors

Author

Ali, S. Wazed, Altin, Yasin, Basak, Santanu, Bashari, Azadeh, Borazan, İsmail, Boukhriss, Aicha, Çelik Bedeloğlu, Ayşe, Chatterjee, Arobindo, Chavan, Pravin P., Chawla, Raman, Eid, Basma M., Gmouh, Said, Goel, Rajeev, Gupta, Bharat, Ibrahim, Nabil A., Ji, Bolin, Jogur, Ganesh, Kafafy, Hany, Khatkar, Vikas, Khedkar, Shweta Shrinivas, Koohestani, Amirhossein Salehi, Kulshrestha, Shweta, Kumar, Vikas, Maity, Subhankar, Majid, Sanaa, Mallick, Aranya Soumyanath Chhabi, Malucelli, Giulio, Mishra, Anu, Nair, Ashrit, Nouri, Alireza, Pandit, Pintu, Purwar, Roli, R N, Manjunath, Ray, Amal, Rohani Shirvan, Anahita, Sachan, Radha, Sbai, Sara Jamoudi, Sezer Hiçyilmaz, Ayşe, Shakeri, Mina, Sharaf, Samar M., Sharma, Navneet, Singha, Kunal, Sun, Gang, Tang, Peixin, Ünsal, Ömer Faruk, and Yüksel Yilmaz, Ayten Nur

Published
2020
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19. Tomentosin Induces Telomere Shortening and Caspase-Dependant Apoptosis in Cervical Cancer Cells

Author

Merghoub, Nawel, primary, El Btaouri, Hassan, additional, Benbacer, Laila, additional, Gmouh, Saïd, additional, Trentesaux, Chantal, additional, Brassart, Bertrand, additional, Attaleb, Mohammed, additional, Madoulet, Claudie, additional, Wenner, Thomas, additional, Amzazi, Saaid, additional, Morjani, Hamid, additional, and El Mzibri, Mohamed, additional

Published
2016
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20. Inula ViscosaExtracts Induces Telomere Shortening and Apoptosis in Cancer Cells and Overcome Drug Resistance

Author

Merghoub, Nawal, primary, El Btaouri, Hassan, additional, Benbacer, Laila, additional, Gmouh, Saïd, additional, Trentesaux, Chantal, additional, Brassart, Bertrand, additional, Terryn, Christine, additional, Attaleb, Mohammed, additional, Madoulet, Claudie, additional, Benjouad, Abdelaziz, additional, Amzazi, Saaïd, additional, El Mzibri, Mohammed, additional, and Morjani, Hamid, additional

Published
2016
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21. Ionic liquid droplet as e-microreactor

Author

P. Marchand G. Fouillet Y. Berthier J. Douki F. Hassine F. Gmouh S. Vaultier M., Dubois, DUBOIS, Philippe, Marchand, Gilles, Fouillet, Yves, Berthier, Jean, Douki, Thierry, Hassine, Fatima, Gmouh, Saïd, Vaultier, Michel, Synthèse et électrosynthèse organiques (SESO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Ions, Molecular Structure, Chemistry, Microfluidics, Analytical chemistry, Water, Nanotechnology, 02 engineering and technology, Dielectric, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Mass Spectrometry, 0104 chemical sciences, Analytical Chemistry, chemistry.chemical_compound, Reagent, Ionic liquid, Electrowetting, Organic synthesis, Microreactor, 0210 nano-technology, Volatility (chemistry)
Abstract

A powerful approach combining a droplet-based, open digital microfluidic lab-on-a-chip using task-specific ionic liquids as soluble supports to perform solution-phase synthesis is reported as a new tool for chemical applications. The negligible volatility of ionic liquids enables their use as stable droplet reactors on a chip surface under air. The concept was validated with different ionic liquids and with a multicomponent reaction. Indeed, we showed that different ionic liquids can be moved by electrowetting on dielectric (EWOD), and their displacement was compared with aqueous solutions. Furthermore, we showed that mixing ionic liquids droplets, each containing a different reagent, in "open" systems is an efficient way of carrying supported organic synthesis. This was applied to Grieco's tetrahydroquinolines synthesis with different reagents. Analysis of the final product was performed off-line and on-line, and the results were compared with those obtained in a conventional reaction flask. This technology opens the way to easy synthesis of minute amounts of compounds ad libitum without the use of complex, expensive, and bulky robots and allows complete automation of the process for embedded chemistry in a portable device. It offers several advantages, including simplicity of use, flexibility, and scalability, and appears to be complementary to conventional microfluidic lab-on-a-chip devices usually based on continuous-flow in microchannels.

Published
2006
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22. Analogues photoactivables du NADH, du NADPH, du NAD+ ou du NADP+

Author

Slama-Schwok, Anny, Blanchard Desce, Mireille, Gmouh, Saïd, Gautier, Clément, Martin, Jean-Louis, Laboratoire d'optique et biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie et Photonique Moléculaires (CPM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Synthèse et électrosynthèse organiques (SESO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), and Roura, Denis

Subjects
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
Abstract

'invention concerne des analogues photoactivables du NADH, du NADPH, du NAD+ ou du NADP+ permettant de déclencher de façon sélective une séquence enzymatique précise et de ce fait de suivre par spectroscopie optique rapide le fonctionnement de la machinerie enzymatique.

Published
2005

23. Inula Viscosa Extracts Induces Telomere Shortening and Apoptosis in Cancer Cells and Overcome Drug Resistance.

Author

Merghoub, Nawal, El Btaouri, Hassan, Benbacer, Laila, Gmouh, Saïd, Trentesaux, Chantal, Brassart, Bertrand, Terryn, Christine, Attaleb, Mohammed, Madoulet, Claudie, Benjouad, Abdelaziz, Amzazi, Saaïd, El Mzibri, Mohammed, and Morjani, Hamid

Subjects
PHYTOTHERAPY, ANTINEOPLASTIC agents, APOPTOSIS, BIOLOGICAL assay, CELL culture, CELL physiology, CHROMATOGRAPHIC analysis, DEVELOPING countries, DRUG resistance, GENES, NUCLEOTIDES, NUTRITION, PAPILLOMAVIRUS diseases, PROTEOLYTIC enzymes, PUBLIC health, RESEARCH funding, T-test (Statistics), TUMORS, PLANT extracts, CERVIX uteri tumors, DATA analysis, CYTOTOXINS, DESCRIPTIVE statistics, DISEASE complications, DIAGNOSIS, TUMOR risk factors
Abstract

Telomerase is activated in human papillomavirus (HPV) positive cervical cancer and targeting telomeres offers a novel anticancer therapeutic strategy. In this study, the telomere targeting properties, the cytotoxic as well as the pro-apoptotic effects of hexane (IV-HE) and dichloromethane (IV-DF) fractions from Inula viscosa L. extracts were investigated on human cervical HeLa and SiHa cancer cells. Our data demonstrate that IV-HE and IV-DF extracts were able to inhibit cell growth in HeLa and SiHa cells in a dose-dependent manner and studied resistant cell lines exhibited a resistance factor less than 2 when treated with the extracts. IV-HE and IV-DF extracts were able to inhibit telomerase activity and to induce telomere shortening as shown by telomeric repeat amplification protocol and TTAGGG telomere length assay, respectively. The sensitivity of fibroblasts to the extracts was increased when telomerase was expressed. Finally, IV-HE and IV-DF were able to induce apoptosis as evidenced by an increase in annexin-V labeling and caspase-3 activity. This study provides the first evidence that the IV-HE and IV-DF extracts from Inula viscosa L. target telomeres induce apoptosis and overcome drug resistance in tumor cells. Future studies will focus on the identification of the molecules involved in the anticancer activity. [ABSTRACT FROM AUTHOR]

Published
2016
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24. Tomentosin Induces Telomere Shortening and Caspase-Dependant Apoptosis in Cervical Cancer Cells.

Author

Merghoub N, El Btaouri H, Benbacer L, Gmouh S, Trentesaux C, Brassart B, Attaleb M, Madoulet C, Wenner T, Amzazi S, Morjani H, and El Mzibri M

Subjects
Apoptosis drug effects, Apoptosis genetics, Blotting, Western, Caspase 3 genetics, Caspase 3 metabolism, Cell Cycle Checkpoints drug effects, Cell Cycle Checkpoints genetics, Cell Division drug effects, Cell Division genetics, Cell Line, Tumor, Cell Proliferation drug effects, Cell Proliferation genetics, Female, G2 Phase drug effects, G2 Phase genetics, HeLa Cells, Humans, Membrane Potential, Mitochondrial drug effects, Membrane Potential, Mitochondrial genetics, Reactive Oxygen Species metabolism, Telomere drug effects, Lactones pharmacology, Sesquiterpenes pharmacology, Telomere genetics, Uterine Cervical Neoplasms genetics
Abstract

Tomentosin, a natural sesquiterpene lactone purified from of Inula viscosa L., was investigated for its anti-proliferative, telomere shortening, and apoptotic effects on human cervical cancer HeLa and SiHa cell lines. Tomentosin was found to inhibit the growth of SiHa and HeLa cell lines in dose and time-dependent manner (IC 50 values of 7.10 ± 0.78 μM and 5.87 ± 0.36 μM, respectively after 96 h of treatment). As evidenced by TTAGGG telomere length assay, tomentosin target specifically the telomeric overhang lengthening. This was confirmed by the evaluation of the cytotoxic effects of tomentosin in the foetal fibroblast Wi38 and JW10 cells which were derived from Wi38 and express hTERT, the telomerase catalytic subunit. We found that JW10 cells are 4.7-fold more sensitive to tomentosin which argues for telomere as its specific target. Furthermore, we found that tomentosin mediate this cytotoxic effect by inducing apoptosis and cell cycle arrest at G2/M phase. Morphological features of treated cells, as evidenced by Hoechst 33324 staining, revealed that the cytotoxic effect was due to induction of apoptosis. This was accompanied by pro-caspase-3 cleavage, an increase in caspase-3 activity and a cleavage of poly (ADP-ribose) polymerase (PARP). Moreover, tomentosin induced a decrease in mitochondrial membrane potential (ΔΨm) and an increase in reactive oxygen species (ROS), accompanied by a decrease in Bcl-2 expression. This indicates that tomentosin-induced apoptosis may involve a mitochondria-mediated signaling pathway. This study provides the first evidence that tomentosin targets telomere machinery and induces apoptosis in cervical cancer cells. The molecular mechanism underlying tomentosin-induced apoptosis may involve a mitochondria-mediated signaling pathway. J. Cell. Biochem. 118: 1689-1698, 2017. © 2016 Wiley Periodicals, Inc., (© 2016 Wiley Periodicals, Inc.)

Published
2017
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