1. Activity of NAD(P)-Dependent Dehydrogenases of Ovarian Vein Lymphocytes in Women with Pelvic Varicose Veins.
- Author
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Semendyaev AA, Darenskaya MA, Stupin DA, Kolesnikov SI, Semenova NV, Tukhieva DV, and Kolesnikova LI
- Subjects
- Humans, Female, Adult, Malate Dehydrogenase metabolism, Isocitrate Dehydrogenase metabolism, Isocitrate Dehydrogenase genetics, Case-Control Studies, L-Lactate Dehydrogenase metabolism, L-Lactate Dehydrogenase blood, Middle Aged, Glutamate Dehydrogenase metabolism, Glutamate Dehydrogenase blood, Pelvis blood supply, Succinate Dehydrogenase metabolism, Young Adult, Glucosephosphate Dehydrogenase metabolism, Veins enzymology, Varicose Veins pathology, Varicose Veins enzymology, Lymphocytes enzymology, Ovary blood supply, Ovary enzymology
- Abstract
The activities of NAD- and NADP-dependent isocitrate dehydrogenases (NAD-ICDH and NADP-ICDH), NAD- and NADP-dependent glutamate dehydrogenases (NAD-GDH and NADP-GDH), and NAD- and NADP-dependent malate dehydrogenases (NAD-MDH and NADP-MDH) in ovarian veins lymphocytes in 183 women of reproductive age with pelvic varicose veins (PVV) and 30 women in the control group were determined. The indicators of intracellular enzymatic activity showed multidirectional changes with increasing severity of the disease. Compared to the control group, women with stage II of PVV had higher median values for lactate dehydrogenase (16.69), NAD-GDH (39.48), NADP-GDH (7.48), NADP-MDH (9.06) and lower values of NAD-ICDH (65.41). Women with stage III of PVV had lower median values for succinate dehydrogenase (9.27), NAD-MDH (26.19), and higher values for glucose-6-phosphate dehydrogenase (8.62), lactate dehydrogenase (24.67), NAD-GDH (63.81), NADP-MDH (21.05) compared to the control group. Studying the activity of NAD(P)-dependent dehydrogenases in lymphocytes at the local level during PVV allows us to evaluate the intensity and dynamics of local varicose veins progression, as well as to optimize its correction., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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