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1. #1858 Delirium among patients admitted to a Nephrology ward-risk factors and association with short-term outcomes: an observational prospective cohort study

Author

Gadalean, Florica, primary, Milas, Oana, additional, Suteanu-Simulescu, Anca, additional, Glavan, Mihaela, additional, Ienciu, Silvia, additional, Mogos, Maria, additional, Balint, Lavinia, additional, Kigyosi, Raluca, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Schiller, Adalbert, additional, and Petrica, Ligia, additional

Published
2024
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3. Mitochondrial DNA and Inflammation Are Associated with Cerebral Vessel Remodeling and Early Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus.

Author

Petrica, Ligia, Gadalean, Florica, Muntean, Danina Mirela, Jianu, Dragos Catalin, Vlad, Daliborca, Dumitrascu, Victor, Bob, Flaviu, Milas, Oana, Suteanu-Simulescu, Anca, Glavan, Mihaela, Ursoniu, Sorin, Balint, Lavinia, Mogos-Stefan, Maria, Ienciu, Silvia, Cretu, Octavian Marius, Popescu, Roxana, Gluhovschi, Cristina, Iancu, Lavinia, and Vlad, Adrian

Subjects
DIABETIC nephropathies, MITOCHONDRIAL DNA, TYPE 2 diabetes, CD54 antigen, NADH dehydrogenase, INTERNAL carotid artery, TUMOR necrosis factors
Abstract

Cerebrovascular disease accounts for major neurologic disabilities in patients with type 2 diabetes mellitus (DM). A potential association of mitochondrial DNA (mtDNA) and inflammation with cerebral vessel remodeling in patients with type 2 DM was evaluated. A cohort of 150 patients and 30 healthy controls were assessed concerning urinary albumin/creatinine ratio (UACR), synaptopodin, podocalyxin, kidney injury molecule-1 (KIM-1), N-acetyl-β-(D)-glucosaminidase (NAG), interleukins IL-17A, IL-18, IL-10, tumor necrosis factor-alpha (TNFα), intercellular adhesion molecule-1 (ICAM-1). MtDNA-CN and nuclear DNA (nDNA) were quantified in peripheral blood and urine by qRT-PCR. Cytochrome b (CYTB) gene, subunit 2 of NADH dehydrogenase (ND2), and beta 2 microglobulin nuclear gene (B2M) were assessed by TaqMan assays. mtDNA-CN was defined as the ratio of the number of mtDNA/nDNA copies, through analysis of the CYTB/B2M and ND2/B2M ratio; cerebral Doppler ultrasound: intima-media thickness (IMT)—the common carotid arteries (CCAs), the pulsatility index (PI) and resistivity index (RI)- the internal carotid arteries (ICAs) and middle cerebral arteries (MCAs), the breath-holding index (BHI). The results showed direct correlations of CCAs-IMT, PI-ICAs, PI-MCAs, RI-ICAs, RI-MCAs with urinary mtDNA, IL-17A, IL-18, TNFα, ICAM-1, UACR, synaptopodin, podocalyxin, KIM-1, NAG, and indirect correlations with serum mtDNA, IL-10. BHI correlated directly with serum IL-10, and serum mtDNA, and negatively with serum IL-17A, serum ICAM-1, and NAG. In neurologically asymptomatic patients with type 2 DM cerebrovascular remodeling and impaired cerebrovascular reactivity may be associated with mtDNA variations and inflammation from the early stages of diabetic kidney disease. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Rapid Decline of Estimated Glomerular Filtration Rate and its Effect on Mortality Risk of Patients with Hepatocellular Carcinoma

Author

Gadalean, Florica, primary, Parv, Florina, additional, Petrica, Ligia, additional, Sporea, Ioan, additional, Timar, Bogdan, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Milas, Oana, additional, Simulescu, Anca, additional, Patruica, Mihaela, additional, Chisavu, Lazar, additional, Mircea, Ciorcan, additional, Schiller, Adalbert, additional, and Danila, Mirela, additional

Published
2023
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9. Acute Kidney Injury after Endoscopic Retrograde Cholangiopancreatography—A Hospital-Based Prospective Observational Study

Author

Gadalean, Florica, primary, Parv, Florina, additional, Milas, Oana, additional, Petrica, Ligia, additional, Ratiu, Iulia, additional, Miutescu, Bogdan, additional, Goldis, Adrian, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Simulescu, Anca, additional, Patruica, Mihaela, additional, Apostol, Adrian, additional, Ivan, Viviana, additional, Schiller, Adalbert, additional, and Radu, Daniela, additional

Published
2022
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13. MO635: Early Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients is Associated with A Particular Ganglioside Profile, Identified by High-Resolution Tandem Mass Spectrometry:A Pilot Study

Author

Suteanu-Simulescu, Anca, primary, Ica, Raluca, additional, Sarbu, Mirela, additional, Munteanu, Cristian, additional, Gadalean, Florica, additional, Vlad, Adrian, additional, Velciov, Silvia, additional, Anca Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Jianu, Catalin, additional, Cretu, Octavian, additional, Oana Milas, Livia, additional, Mogos, Maria, additional, Patruica, Mihaela, additional, Lavinia, Balint, additional, Silvia, Ienciu, additional, Diana Zamfir, Alina, additional, and Petrica, Ligia, additional

Published
2022
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14. MO392: Mildly Impaired Kidney Function May Be Associated With the Risk of Hippocampal Atrophy in Young and Midlife Adults

Author

Gadalean, Florica, primary, Virdol, Malina, additional, Schiller, Adalbert, additional, Bob, Flaviu, additional, Anca Gluhovschi, Cristina, additional, Oana Milas, Livia, additional, Suteanu - Simulescu, Anca, additional, Patruica, Mihaela, additional, Chisavu, Lazar, additional, Dana Grosu, Iulia, additional, Iova, Iasmina, additional, Florina, Parv, additional, and Petrica, Ligia, additional

Published
2022
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16. MO635PRO-INFLAMMATORY CYTOKINES IL-6 AND IL-17 DISPLAY A PARTICULAR MOLECULAR PATTERN IN ASSOCIATION WITH DYSREGULATED MIRNAS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN THE EARLY STAGES OF DIABETIC KIDNEY DISEASE

Author

Golea Alina-Emanuela, Petru Matusz, Mihaela Patruica, Gluhovschi Cristina, Florica Gadalean, Silvia Velciov, Ligia Petrica, Balint Lavinia, Adrian Vlad, Agneta Maria Pusztai, Anca Simulescu, Mihaela Vlad, Motoc Andrei, Mogos-Stefan Maria, Daliborca Vlad, Dumitrascu Victor, Flaviu Bob, Ienciu Silvia, Octavian Cretu, Livia Oana Milas, Roxana Popescu, Sorin Ursoniu, and Catalin Jianu

Subjects
Transplantation, Diabetic kidney, biology, business.industry, Type 2 Diabetes Mellitus, Disease, Proinflammatory cytokine, Nephrology, microRNA, Immunology, biology.protein, Medicine, In patient, Interleukin 17, Interleukin 6, business
Abstract

Background and Aims Glomerular injury and proximal tubule (PT) dysfunction have intricate mechanisms in diabetic kidney disease (DKD). Pro-inflammatory cytokines are involved in the initiation and progression of DKD through mediating the inflammatory response, both at glomerular and proximal tubular level. miRNAs are able to modulate cellular and biochemical functions, thus intervening in the pathogenesis of DKD. The aim of the study, performed on patients with type 2 diabetes mellitus (DM), was to evaluate selective pro-inflammatory cytokines in relation to biomarkers of podocyte lesion and of PT dysfunction. Particular molecular pathways, such as specific miRNA profiles operating in this relation, have also been studied. Method A number of 126 patients with type 2 DM, staged by albuminuria [39 normoalbuminuric – urinary albumin/creatinine ratio UACR)300mg/g], and 23 healthy control subjects were included in a cross-sectional study. All patients were evaluated concerning biomarkers of podocyte injury (nephrin, podocalyxin, synaptopodin) and of PT dysfunction [Kidney injury molecule-1(KIM-1), N-acetyl-beta-D-glucuronidase (NAG), alpha 1- microglobulin]. Also, serum and urinary levels of specific interleukins (IL-6, IL-17), serum cystatin C, and eGFR were determined. Serum and urinary miRNAs (miRNA-21, miRNA-124, miRNA-146a, miRNA-192) were assessed by RT-PCR. Results The biomarkers of podocyte lesion and of PT dysfunction were increased, even in normoalbuminuric type 2 DM patients. Serum and urinary IL-6 and IL-17 showed increased levels in type 2 DM patients, across all groups studied. The model provided by univariable regression analysis showed that IL-6 and IL-17 correlated directly with biomarkers of podocyte injury (nephrin, podocalyxin, synaptopodin), of PT dysfunction (KIM-1, NAG, alpha 1-microglobulin), as well as with UACR. Negative correlations have been identified regarding eGFR. In multivariable regression analysis, serum IL-6 correlated directly with synaptopodin, NAG, and negatively with eGFR (p Also, important associations were found between specific interleukins and miRNAs. In univariable regression analysis, IL-6 and IL-17 correlated directly with miRNA-21 and miRNA-124, and negatively with miRNA-146a and miRNA-192. The models provided by multivariable regression analysis showed that urinary IL-6 correlated directly with urinary miRNA-21, and negatively with urinary miRNA-192 (p Conclusion In the early stages of DKD, there is an association of pro-inflammatory cytokines with specific miRNAs, and with biomarkers of podocyte injury and of PT dysfunction. IL-6 and IL-17, as well as dysregulated miRNA-21, miRNA-124, miRNA-146a, and miRNA-192 display a particular molecular pattern, in relation to complex mechanisms that can initiate and maintain the chronic inflammatory response in DKD. Routine detection of these interleukins may provide biomarkers to refine the diagnosis of early renal involvement in the course of type 2 DM, independently of albuminuria and level of renal function.

Published
2021

18. Idiopathic retroperitoneal fibrosis with particular perirenal and intrarenal extension associated with left renal artery stenosis. The atheromatous periaortitis with retroperitoneal fibrosis suggests a pathogenic relationship between atherosclerosis and fibrosis?

Author

Gluhovschi, Gheorghe, Bozdog, Gheorghe, Miclaus, Gratian, Puscasiu, Tudor, Gluhovschi, Cristina, Bob, Flaviu, Velciov, Silvia, Petrica, Ligia, Trandafirescu, Virginia, and Gadalean, Florica

Published
2011
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21. MO350ACUTE KIDNEY INJURY RELATED TO ENDOSCOPIC RETROGRADE COLANGIO-PANCREATOGRAPHY IS ASSOCIATED WITH INCREASED INCIDENCE OF IN-HOSPITAL MORTALITY

Author

Gadalean, Florica, primary, Florina, Parv, additional, Schiller, Adalbert, additional, Bob, Flaviu, additional, Gluhovschi, Cristina, additional, Oana, Milas, additional, Mihaescu, Adelina, additional, Simulescu, Anca, additional, Golea-Secara, Alina, additional, Chisavu, Lazar, additional, Grosu, Iulia Dana, additional, Marc, Luciana, additional, Ratiu, Iulia, additional, Goldis, Adrian, additional, Miutescu, Bogdan, additional, Riza, Andrei, additional, and Petrica, Ligia, additional

Published
2021
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23. Long noncoding RNAs may impact podocytes and proximal tubule function through modulating miRNAs expression in Early Diabetic Kidney Disease of Type 2 Diabetes Mellitus patients

Author

Petrica, Ligia, primary, Hogea, Elena, additional, Gadalean, Florica, additional, Vlad, Adrian, additional, Vlad, Mihaela, additional, Dumitrascu, Victor, additional, Velciov, Silvia, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Ursoniu, Sorin, additional, Jianu, Dragos Catalin, additional, Matusz, Petru, additional, Pusztai, Agneta-Maria, additional, Motoc, Andrei, additional, Cretu, Octavian M, additional, Radu, Dana, additional, Milas, Oana, additional, Golea-Secara, Alina, additional, Simulescu, Anca, additional, Mogos-Stefan, Maria, additional, Patruica, Mihaela, additional, Balint, Lavinia, additional, Ienciu, Silvia, additional, Vlad, Daliborca, additional, and Popescu, Roxana, additional

Published
2021
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25. Urinary proteins detected using modern proteomics intervene in early type 2 diabetic kidney disease – a pilot study

Author

Golea-Secara, Alina, primary, Munteanu, Cristian, additional, Sarbu, Mirela, additional, Cretu, Octavian M, additional, Velciov, Silvia, additional, Vlad, Adrian, additional, Bob, Flaviu, additional, Gadalean, Florica, additional, Gluhovschi, Cristina, additional, Milas, Oana, additional, Simulescu, Anca, additional, Mogos-Stefan, Maria, additional, Patruica, Mihaela, additional, Petrica, Ligia, additional, and Zamfir, Alina D, additional

Published
2020
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26. P0750ASSOCIATION OF SERUM POTASSIUM LEVELS WITH RAPID KIDNEY FUNCTION DECLINE IN PATIENTS WITH CONGENITAL SINGLE KIDNEY

Author

GADALEAN, FLORICA, primary, Parv, Florina, primary, Petrica, Ligia, primary, VELCIOV, SILVIA, primary, Gluhovschi, Cristina Anca, primary, Bob, Flaviu, primary, OANA, MILAS, primary, Mihaescu, Adelina, primary, GOLEA-SECARA, ALINA, primary, SIMULESCU, ANCA, primary, Grosu, Iulia Dana, primary, Chisavu, Lazar, primary, Floroiu, Madalina, primary, and Schiller, Adalbert, primary

Published
2020
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27. P1005LONG NONCODING RNAS MAY INTERVENE IN PODOCYTE INJURY AND PROXIMAL TUBULE DYSFUNCTION THROUGH MODULATING MIRNAS EXPRESSION IN EARLY DIABETIC KIDNEY DISEASE OF TYPE 2 DIABETES MELLITUS PATIENTS

Author

Petrica, Ligia, primary, GADALEAN, FLORICA, primary, VLAD, ADRIAN, primary, Vlad, Mihaela, primary, DUMITRASCU, VICTOR, primary, VELCIOV, SILVIA, primary, Gluhovschi, Cristina Anca, primary, Bob, Flaviu, primary, URSONIU, SORIN, primary, JIANU, CATALIN, primary, MATUSZ, PETRU, primary, Pusztai, Agneta, primary, CRETU, OCTAVIAN, primary, OANA, MILAS, primary, GOLEA-SECARA, ALINA, primary, SIMULESCU, ANCA, primary, MOGOS-STEFAN, MARIA, primary, PATRUICA, MIHAELA, primary, POPESCU, ROXANA, primary, and Vlad, Daliborca, primary

Published
2020
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28. Pro-inflammatory cytokines are associated with podocyte damage and proximal tubular dysfunction in the early stage of diabetic kidney disease in type 2 diabetes mellitus patients

Author

Milas, Oana, primary, Gadalean, Florica, additional, Vlad, Adrian, additional, Dumitrascu, Victor, additional, Velciov, Silvia, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Popescu, Roxana, additional, Ursoniu, Sorin, additional, Jianu, Dragos Catalin, additional, Matusz, Petru, additional, Pusztai, Agneta-Maria, additional, Secara, Alina, additional, Simulescu, Anca, additional, Stefan, Maria, additional, Patruica, Mihaela, additional, Petrica, Flaviu, additional, Vlad, Daliborca, additional, and Petrica, Ligia, additional

Published
2020
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29. Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients

Author

Petrica, Ligia, primary, Milas, Oana, additional, Vlad, Mihaela, additional, Vlad, Adrian, additional, Gadalean, Florica, additional, Dumitrascu, Victor, additional, Velciov, Silvia, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Ursoniu, Sorin, additional, Jianu, Dragos C, additional, Matusz, Petru, additional, Pusztai, Agneta-Maria, additional, Cretu, Octavian, additional, Radu, Daniela, additional, Secara, Alina, additional, Simulescu, Anca, additional, Stefan, Maria, additional, Popescu, Roxana, additional, and Vlad, Daliborca, additional

Published
2019
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33. MiRNA Expression is Associated with Clinical Variables Related to Vascular Remodeling in the Kidney and the Brain in Type 2 Diabetes Mellitus Patients

Author

Petrica, Ligia, primary, Pusztai, Agneta-Maria, additional, Vlad, Mihaela, additional, Vlad, Adrian, additional, Gadalean, Florica, additional, Dumitrascu, Victor, additional, Vlad, Daliborca, additional, Velciov, Silvia, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Ursoniu, Sorin, additional, Petrica, Maxim, additional, Matusz, Petru, additional, Cretu, Octavian, additional, Radu, Daniela, additional, Milas, Oana, additional, Secara, Alina, additional, Simulescu, Anca, additional, Popescu, Roxana, additional, and Jianu, Dragos Catalin, additional

Published
2019
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34. FP510PRO-INFLAMATORY CITOKINES (IL 1 ALPHA, IL 8 AND IL 18) ARE ASSOCIATED WITH PODOCYTE DAMAGE AND PROXIMAL TUBULAR DYSFUNCTION IN THE EARLY STAGE OF DIABETIC KIDNEY DISEASE IN TYPE 2 DIABETES MELLITUS PATIENTS

Author

Milas, Oana, primary, Gadalean, Florica, additional, Secara, Alina, additional, Simulescu, Anca, additional, Vlad, Adrian, additional, Dumitrascu, Victor, additional, Popescu, Roxana, additional, Velciov, Silvia, additional, Bob, Flaviu, additional, Gluhovschi, Cristina, additional, Matusz, Petru, additional, Pusztai, Agneta Maria, additional, Cretu, Octavian, additional, Ursoniu, Sorin, additional, Vlad, Daliborca, additional, and Petrica, Ligia, additional

Published
2019
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35. MiRNA Expression is Associated with Clinical Variables Related to Vascular Remodeling in the Kidney and the Brain in Type 2 Diabetes Mellitus Patients.

Author

Petrica, Ligia, Pusztai, Agneta-Maria, Vlad, Mihaela, Vlad, Adrian, Gadalean, Florica, Dumitrascu, Victor, Vlad, Daliborca, Velciov, Silvia, Gluhovschi, Cristina, Bob, Flaviu, Ursoniu, Sorin, Petrica, Maxim, Matusz, Petru, Cretu, Octavian, Radu, Daniela, Milas, Oana, Secara, Alina, Simulescu, Anca, Popescu, Roxana, and Jianu, Dragos Catalin

Subjects
VASCULAR remodeling, TYPE 2 diabetes, MICRORNA, PEOPLE with diabetes, KIDNEYS
Abstract

Background: The association of vascular remodeling in the kidney and the brain with a particular microRNAs (miRNA) profile is not well studied. Methods: Seventy-six patients with Type 2 diabetes and 11 healthy subjects were assessed concerning urine albumin: creatinine ratio (UACR), biomarkers of podocyte injury and of proximal tubule (PT) dysfunction. MiRNA were quantified in blood and urine by a real-time PCR System. Cerebrovascular ultrasound measurements were performed in the carotid and middle cerebral arteries. Results: MiRNA21 and miRNA124 correlated positively with nephrin, podocalyxin, synaptopodin, urinary N-acetyl-D-glucosaminidase (NAG), urinary kidney-injury molecule-1 (KIM-1), UACR, and negatively with eGFR; miRNA125a, 126, 146a, 192 correlated negatively with nephrin, podocalyxin, synaptopodin, urinary NAG, urinary KIM-1, UACR, and directly with eGFR. Plasma miRNA-21 and miRNA192 correlated directly with cerebral hemodynamics parameters of atherosclerosis and arteriosclerosis. MiRNA-124, 125a, 126, 146a showed negative correlations with the same parameters. Conclusions: In Type 2 diabetes patients there is an association of vascular remodeling in the brain and the kidney with a specific miRNAs pattern. Cerebrovascular changes occur even in normoalbuminuric patients, with 'high-to-normal' levels of podocyte injury and PT dysfunction biomarkers. These phenomena may be explained by the variability of miRNA expression within the two organs in early DKD. [ABSTRACT FROM AUTHOR]

Published
2020
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36. Deregulated Profiles of Urinary Micrornas May Explain Podocyte Injury and Proximal Tubule Dysfunction in Normoalbuminuric Patients with Type 2 Diabetes Mellitus

Author

Milas, Oana, primary, Gadalean, Florica, additional, Vlad, Adrian, additional, Dumitrascu, Victor, additional, Gluhovschi, Cristina, additional, Gluhovschi, Gheorghe, additional, Velciov, Silvia, additional, Popescu, Roxana, additional, Bob, Flaviu, additional, Matusz, Petru, additional, Pusztai, Agneta-Maria, additional, Cretu, Octavian M, additional, Secara, Alina, additional, Simulescu, Anca, additional, Ursoniu, Sorin, additional, Vlad, Daliborca, additional, and Petrica, Ligia, additional

Published
2018
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37. Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy

Author

Gluhovschi, Cristina, Gluhovschi, Gheorghe, Petrica, Ligia, Timar, Romulus, Velciov, Silvia, Ionita, Ioana, Kaycsa, Adriana, and Timar, Bogdan

Subjects
Article Subject
Abstract

Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition—mainly cardiovascular ones—and for monitoring its progression. New researches are pointing that some of these biomarkers (i.e., glomerular, tubular, inflammation markers, and biomarkers of oxidative stress) precede albuminuria in some patients. However, their usefulness is widely debated in the literature and has not yet led to the validation of a new “gold standard” biomarker for the early diagnosis of DN. Currently, microalbuminuria is an important biomarker for both glomerular and tubular injury. Other glomerular biomarkers (transferrin and ceruloplasmin) are under evaluation. Tubular biomarkers in DN seem to be of a paramount importance in the early diagnosis of DN since tubular lesions occur early. Additionally, biomarkers of inflammation, oxidative stress, podocyte biomarkers, and vascular biomarkers have been employed for assessing early DN. The purpose of this review is to provide an overview of the current biomarkers used for the diagnosis of early DN.

Published
2016
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38. 'Does chronic kidney disease define a particular risk pattern of cerebral vessels modifications in patients with symptomatic ischemic cerebrovascular disease?'

Author

Bob Flaviu, Trandafirescu Virginia, Ursoniu Sorin, Velciov Silvia, Gluhovschi Gheorghe, Gluhovschi Cristina, Bozdog Gheorghe, Muresan Carmina, Matcau Diana, Matcau Liviu, Ligia Petrica, Jianu Catalin, Maxim Petrica, and Gadalean Florica

Subjects
medicine.medical_specialty, Neurology, Cerebral arteries, Hemodynamics, Renal function, urologic and male genital diseases, Fibrinogen, Internal medicine, medicine, risk factors, Stroke, transcranial doppler ultrasound, business.industry, extracranial doppler ultrasound, General Medicine, medicine.disease, female genital diseases and pregnancy complications, cerebrovascular disease, Transcranial Doppler, Cardiology, Medicine, business, chronic kidney disease, medicine.drug, Kidney disease
Abstract

Cardiovascular complications, including stroke, may be attributed the highest rate of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of our study was to evaluate the prevalence of CKD in patients with symptomatic ischaemic cerebrovascular disease and to establish of whether CKD may define a particular risk pattern of cerebral vessels modifications in this category of patients. The prevalence of CKD was evaluated in 590 consecutive patients with symptomatic ischaemic cerebrovascular disease admitted to a department of neurology. The types of stroke, the vascular territories, the vascular modifications and the haemodynamic changes (resistance index- RI) found by neurosonology (extracranial and transcranial Doppler ultrasound) were analysed in relation to classic and non-classic cerebrovascular risk factors, as well as to stages of CKD (defined by estimated glomerular filtration rate-eGFR-MDRD4 formula-K/DOQI 2002). The prevalence of CKD in the studied patients was 70.84%. Atherosclerosis in a diffuse pattern was detected in 79.7% of CKD patients, while carotid artery stenoses were found in 10% of cases, occlusions- 5.3%, stenoses + occlusions-1.2%, and multiple stenoses- 3.8% of cases. The RI evaluated in the internal carotid arteries correlated with fibrinogen(P

Published
2010

39. The impact of acute kidney injury on in-hospital mortality in acute ischemic stroke patients undergoing intravenous thrombolysis

Author

Gadalean, Florica, primary, Simu, Mihaela, additional, Parv, Florina, additional, Vorovenci, Ruxandra, additional, Tudor, Raluca, additional, Schiller, Adalbert, additional, Timar, Romulus, additional, Petrica, Ligia, additional, Velciov, Silvia, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Mihaescu, Adelina, additional, Timar, Bogdan, additional, Spasovski, Goce, additional, and Ivan, Viviana, additional

Published
2017
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40. Podocyturia parallels proximal tubule dysfunction in type 2 diabetes mellitus patients independently of albuminuria and renal function decline: A cross-sectional study

Author

Petrica, Ligia, primary, Vlad, Mihaela, additional, Vlad, Adrian, additional, Gluhovschi, Gheorghe, additional, Gadalean, Florica, additional, Dumitrascu, Victor, additional, Popescu, Roxana, additional, Gluhovschi, Cristina, additional, Matusz, Petru, additional, Velciov, Silvia, additional, Bob, Flaviu, additional, Ursoniu, Sorin, additional, and Vlad, Daliborca, additional

Published
2017
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41. Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus

Author

Petrica, Ligia, primary, Ursoniu, Sorin, additional, Gadalean, Florica, additional, Vlad, Adrian, additional, Gluhovschi, Gheorghe, additional, Dumitrascu, Victor, additional, Vlad, Daliborca, additional, Gluhovschi, Cristina, additional, Velciov, Silvia, additional, Bob, Flaviu, additional, Matusz, Petru, additional, Milas, Oana, additional, Secara, Alina, additional, Simulescu, Anca, additional, and Popescu, Roxana, additional

Published
2017
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42. MP379CHRONIC KIDNEY DISEASE AS A RISK FACTOR FOR ANTIMICROBIAL MULTIDRUG RESISTANCE OF UROPATHOGENIC BACTERIA

Author

Gadalean, Florica, primary, Parv, Florina, additional, Morariu, Vlad, additional, Popa, Anca, additional, Timar, Romulus, additional, Petrica, Ligia, additional, Schiller, Oana, additional, Velciov, Silvia, additional, Gluhovschi, Cristina, additional, Mihaescu, Adelina, additional, Bob, Flaviu, additional, Bozdog, Gheorghe, additional, Timar, Bogdan, additional, and Schiller, Adalbert, additional

Published
2017
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43. SP439PARTICULAR PROFILES OF URINARY MICRO-RNAs MAY EXPLAIN PODOCYTE INJURY AND PROXIMAL TUBULE DYSFUNCTION IN NORMOALBUMINURIC PATIENTS WITH TYPE 2 DIABETES MELLITUS

Author

Petrica, Ligia, primary, Gadalean, Florica, additional, Vlad, Adrian, additional, Dumitrascu, Victor, additional, Gluhovschi, Cristina, additional, Gluhovschi, Gheorghe, additional, Velciov, Silvia, additional, Popescu, Roxana, additional, Bob, Flaviu, additional, Petrica, Maxim, additional, Jianu, Catalin, additional, Matusz, Petru, additional, Milas, Oana, additional, Secara, Alina, additional, Simulescu, Anca, additional, Ursoniu, Sorin, additional, and Vlad, Daliborca, additional

Published
2017
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45. Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus—An Immunological Dilemma

Author

Gluhovschi, Cristina, Gluhovschi, Gheorghe, Petrica, Ligia, Velciov, Silvia, and Gluhovschi, Adrian

Subjects
Article Subject, animal diseases, bacteria, chemical and pharmacologic phenomena, biochemical phenomena, metabolism, and nutrition, skin and connective tissue diseases
Abstract

Pregnancy is a physiological condition that requires immune tolerance to the product of conception. Systemic lupus erythematosus (SLE) is a disease with well-represented immune mechanisms that disturb immune tolerance. The association of pregnancy with systemic lupus erythematosus creates a particular immune environment in which the immune tolerance specific of pregnancy is required to coexist with alterations of the immune system caused by SLE. The main role is played by T regulatory (Treg) cells, which attempt to regulate and adapt the immune system of the mother to the new conditions of pregnancy. Other components of the immune system also participate to maintain maternal-fetal immune tolerance. If the immune system of pregnant women with SLE is not able to maintain maternal immune tolerance to the fetus, pregnancy complications (miscarriage, fetal hypotrophy, and preterm birth) or maternal complications (preeclampsia or activation of SLE, especially in conditions of lupus nephritis) may occur. In certain situations this can be responsible for neonatal lupus. At the same time, it must be noted that during pregnancy, the immune system is able to achieve immune tolerance while maintaining the anti-infectious immune capacity of the mother. Immunological monitoring of pregnancy during SLE, as well as of the mother’s disease, is required. It is important to understand immune tolerance to grafts in transplant pathology.

Published
2015
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46. Therapy with atorvastatin versus rosuvastatin reduces urinary podocytes, podocyte-associated molecules, and proximal tubule dysfunction biomarkers in patients with type 2 diabetes mellitus: a pilot study

Author

Vlad, Adrian, primary, Vlad, Mihaela, additional, Petrica, Ligia, additional, Ursoniu, Sorin, additional, Gadalean, Florica, additional, Popescu, Roxana, additional, Vlad, Daliborca, additional, Dumitrascu, Victor, additional, Gluhovschi, Gheorghe, additional, Gluhovschi, Cristina, additional, Velciov, Silvia, additional, Bob, Flaviu, additional, Matusz, Petru, additional, Secara, Alina, additional, Simulescu, Anca, additional, and Jianu, Dragos Catalin, additional

Published
2016
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47. SP382URINARY PODOCYTE-ASSOCIATEDMESSENGER RNA LEVELS CORRELATE WITH PROXIMAL TUBULE DYSFUNCTION IN EARLYDIABETIC NEPHROPATHY OF TYPE 2 DIABETES MELLITUS

Author

Petrica, Ligia, primary, Gadalean, Florica, additional, Vlad, Adrian, additional, Gluhovschi, Gheorghe, additional, Dumitrascu, Victor, additional, Vlad, Daliborca, additional, Gluhovschi, Cristina, additional, Velciov, Silvia, additional, Bob, Flaviu, additional, Petrica, Maxim, additional, Jianu, Dragos Catalin, additional, Ursoniu, Sorin, additional, Milas, Oana, additional, Secara, Alina, additional, Simulescu, Anca, additional, and Popescu, Roxana, additional

Published
2016
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49. Urinary enzymatic markers (N-acetyl-beta-D-glucosaminidase) in assessing the tubulointerstitial compartment in chronic glomerulonephritis related to odontogenic foci

Author

Velciov, Silvia, primary, Gluhovschi, Gheorghe, additional, Timar, Romulus, additional, Gluhovschi, Cristina, additional, Petrica, Ligia, additional, Bob, Flaviu, additional, Bozdog, Gheorghe, additional, Pricop, Marius, additional, Gluhovschi, Adrian, additional, Cornianu, Marioara, additional, Potencz, Elena, additional, Timar, Bogdan, additional, and Kaycsa, Adriana, additional

Published
2015
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50. SP462URINARY PODOCYTES ARE ASSOCIATED WITH PROXIMAL TUBULE DYSFUNCTION IN TYPE 2 DIABETES MELLITUS PATIENTS: A CROSS-SECTIONAL STUDY

Author

Petrica, Ligia, primary, Vlad, Adrian, additional, Gluhovschi, Gheorghe, additional, Gadalean, Florica, additional, Dumitrascu, Victor, additional, Vlad, Daliborca, additional, Popescu, Roxana, additional, Gluhovschi, Cristina, additional, Velciov, Silvia, additional, Bob, Flaviu, additional, Petrica, Maxim, additional, Jianu, Catalin, additional, Milas, Oana, additional, and Ursoniu, Sorin, additional

Published
2015
Full Text
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