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2. The International Society for Heart and Lung Transplantation/Heart Failure Society of America Guideline on Acute Mechanical Circulatory Support

Author

Bernhardt, Alexander M., Gluck, Jason, Garan, Arthur Reshad, Hall, Shelley, Hayanga, Awori, Knezevic, Ivan, Pappalardo, Federico, Wald, Joyce, Amarelli, Cristiano, Baker, William L., Baran, David, Dilling, Daniel, Hogan, Airlie, Meyer, Anna L., Netuka, Ivan, Ono, Minoru, Parilla, Gustavo A, Pham, Duc Thin, Silvestry, Scott, Smith, M. Cristy, Takeda, Koji, Thomas, Sunu S, Vorovich, Esther, Givertz, Michael, Rodgers, Jo Ellen, Aburjania, Nana, Connors, Jean M., Hanke, Jasmin S., Joubert-Huebner, Elrina, Levy, Gal, Woolley, Ann E., Copeland, Hannah, Morales, David, Vest, Amanda, Arabia, Francisco, Carrier, Michael, Salerno, Christopher T., Schrage, Benedikt, Deswal, Anita, Fedson, Savitri, Allen, Larry A., Bither, Cynthia J., Dunlay, Shannon, Morejon, Paola, Kendall, Kay, BERNHARDT, ALEXANDER M., COPELAND, HANNAH, DESWAL, ANITA, GLUCK, JASON, and GIVERTZ, MICHAEL M.

Published
2023
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3. Non-Lung Solid Organ Transplantation From SARS-CoV-2–Positive Donors to Uninfected Recipients

Author

Wade, Jason, Petitpas, Kaitlyn M., Dar, Wasim, Ali, Ayyaz, Radojevic, Joseph A., Lawlor, Michael T., Hammond, Jonathan A., Gluck, Jason, Feingold, Andrew D., Jaiswal, Abhishek, Ebcioglu, Zeynep, Einstein, Michael, Morgan, Glyn, Emmanuel, Bishoy, Ye, Xiaoyi, Singh, Joseph U., Sotil, Eva U., Swales, Colin, Kent, Rebecca, Richardson, Elizabeth, Cheema, Faiqa, and Serrano, Oscar K.

Published
2023
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6. Characteristics and outcomes of patients with COVID-19 supported by extracorporeal membrane oxygenation: A retrospective multicenter study

Author

Alvarez, Chikezie, DeAnda, Abe, Jr., Gluck, Jason, Jermyn, Rita, Kuntzman, Matthew, McKellar, Stephen, Parides, Michael K., Saunders, Paul, Saeed, Omar, Tatooles, Antone J., Farooq, Muhammad, Schwartz, Gary, Pham, Duc T., Mustafa, Asif K., D'Alessandro, David, Abrol, Sunil, Jorde, Ulrich P., Gregoric, Igor D., Radovancevic, Rajko, Lima, Brian, Bryner, Benjamin S., Ravichandran, Ashwin, Salerno, Christopher T., Spencer, Philip, Friedmann, Patricia, Silvestry, Scott, and Goldstein, Daniel J.

Published
2022
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8. 420.6: Transplantation of Organs From SARS-CoV-2-Positive Donors To Uninfected (Non-lung) Solid Organ Transplant Recipients Has Not Resulted in Significant SARS-CoV-2 Related Morbidity Or Mortality

Author

Dar, Wasim, Wade, Jason, Ali, Ayyaz, Radojevic, Joseph A., Lawlor, Michael T., Hammond, Jonathan A., Gluck, Jason, Feingold, Andrew D., Jaiswal, Abhishek, Ebcioglu, Zeynep, Einstein, Michael, Morgan, Glyn, Emmanuel, Bishoy, Ye, Xiaoyi, Singh, Joseph, Sotil, Eva U., Swales, Colin, Kent, Rebecca, Richardson, Elizabeth, Tremaglio, Joseph, Cheema, Faiqa, and Serrano, Oscar

Published
2022
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10. Imipenem/relebactam pharmacokinetics in critically ill patients supported on extracorporeal membrane oxygenation.

Author

Fratoni, Andrew J, Kois, Abigail K, Gluck, Jason A, Nicolau, David P, and Kuti, Joseph L

Subjects
IMIPENEM, EXTRACORPOREAL membrane oxygenation, CRITICALLY ill, PHARMACOKINETICS, MONTE Carlo method, PSEUDOMONAS aeruginosa
Abstract

Background Extracorporeal membrane oxygenation (ECMO) is a life-saving modality but has the potential to alter the pharmacokinetics (PK) of antimicrobials. Imipenem/cilastatin/relebactam is an antibiotic with utility in treating certain multi-drug resistant Gram-negative infections. Herein, we describe the population pharmacokinetics of imipenem and relebactam in critically ill patients supported on ECMO. Methods Patients with infection supported on ECMO received 4–6 doses of imipenem/cilastatin/relebactam per current prescribing information based on estimated creatinine clearance. Blood samples were collected following the final dose of the antibiotic. Concentrations were determined via LC–MS/MS. Population PK models were fit with and without covariates using Pmetrics. Monte Carlo simulations of 1000 patients assessed joint PTA of f AUC0–24/MIC ≥ 8 for relebactam, and ≥40% f T > MIC for imipenem for each approved dosing regimen. Results Seven patients supported on ECMO were included in PK analyses. A two-compartment model with creatinine clearance as a covariate on clearance for both imipenem and relebactam fitted the data best. The mean ± standard deviation parameters were: CL0, 15.21 ± 6.52 L/h; Vc, 10.13 ± 2.26 L; K12, 2.45 ± 1.16 h−1 and K21, 1.76 ± 0.49 h−1 for imipenem, and 6.95 ± 1.34 L/h, 9.81 ± 2.69 L, 2.43 ± 1.13 h−1 and 1.52 ± 0.67 h−1 for relebactam. Simulating each approved dose of imipenem/cilastatin/relebactam according to creatinine clearance yielded PTAs of ≥90% up to an MIC of 2 mg/L. Conclusions Imipenem/cilastatin/relebactam dosed according to package insert in patients supported on ECMO is predicted to achieve exposures sufficient to treat susceptible Gram-negative isolates, including Pseudomonas aeruginosa. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Post Heart Transplantation Outcomes of Patients Supported on Biventricular Mechanical Support

Author

Jaiswal, Abhishek, primary, Gadela, Naga Vaishnavi, additional, Baran, David A., additional, Dasgupta, Oisharya, additional, Gluck, Jason, additional, Radojevic, Joseph, additional, Arora, Sabeena, additional, Scatola, Andrew, additional, Ali, Ayyaz, additional, Hammond, Jonathan, additional, Jennings, Douglas L., additional, and Baker, William L., additional

Published
2022
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24. Characteristics and outcomes of patients with COVID-19 supported by extracorporeal membrane oxygenation: A retrospective multicenter study

Author

Saeed, Omar, primary, Tatooles, Antone J., additional, Farooq, Muhammad, additional, Schwartz, Gary, additional, Pham, Duc T., additional, Mustafa, Asif K., additional, D'Alessandro, David, additional, Abrol, Sunil, additional, Jorde, Ulrich P., additional, Gregoric, Igor D., additional, Radovancevic, Rajko, additional, Lima, Brian, additional, Bryner, Benjamin S., additional, Ravichandran, Ashwin, additional, Salerno, Christopher T., additional, Spencer, Philip, additional, Friedmann, Patricia, additional, Silvestry, Scott, additional, Goldstein, Daniel J., additional, Alvarez, Chikezie, additional, DeAnda, Abe, additional, Gluck, Jason, additional, Jermyn, Rita, additional, Kuntzman, Matthew, additional, McKellar, Stephen, additional, Parides, Michael K., additional, and Saunders, Paul, additional

Published
2022
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26. Outcomes by cannulation methods for venovenous extracorporeal membrane oxygenation during COVID‐19: A multicenter retrospective study

Author

Saeed, Omar, primary, Stein, Louis H., additional, Cavarocchi, Nicolas, additional, Tatooles, Antone J., additional, Mustafa, Asif, additional, Jorde, Ulrich P., additional, Alvarez, Chikezie, additional, Gluck, Jason, additional, Saunders, Paul, additional, Abrol, Sunil, additional, De Anda, Abe, additional, Goldstein, Daniel J., additional, and Silvestry, Scott, additional

Published
2022
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32. Application and outcomes of extracorporeal life support in emergency general surgery and trauma.

Author

Brewer, Jennifer M, Tran, Anthony, Yu, Jielin, Ali, M Irfan, Poulos, C M, Gates, Jonathan, Underhill, David, and Gluck, Jason

Subjects
TRAUMA surgery, LIFE support systems in critical care, EXTRACORPOREAL membrane oxygenation, RETROSPECTIVE studies, MANN Whitney U Test, EMERGENCY medical services, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, DATA analysis software, PROBABILITY theory
Abstract

Background: We analyzed the use of Extracorporeal Membranous Oxygenation (ECMO) in acute care surgery patients at our Level-1 trauma center. We hypothesized that this patient population has improved ECMO outcomes. Methods: This was a retrospective analysis of emergency general surgery and trauma patients placed on ECMO between the periods of October 2013 and February 2020. There were 10 surgical and 12 trauma patients studied, who eventually required ECMO support. ECMO support and ECMO type/modality were analyzed with injury and survival prognostic scores examined. Main results: Overall, 16 of the 22 patients survived to hospital discharge, for a survival rate of 73%. Mean age was 34.18 years. Mean hospital length of stay was 23.4 days with mean days on ECMO equal to 7.5. The net negative fluid balance was 5.36 L. Conclusions: The survival of our ECMO cohort is notably higher than previously cited studies. Our group demonstrated decreased length of time on ECMO, decreased length of stay in the hospital, and similar rates of complications compared to prior reports. ECMO is a useful modality in acute care surgical patients and should be considered in these patient populations. Our focus on net negative fluid balance for ECMO patients demonstrates improved survival. ECMO should be considered early in surgical patients and early in advanced trauma life support. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Clinical outcomes of older adults listed for heart transplantation in the United States

Author

Jaiswal, Abhishek, primary, Gadela, Naga Vaishnavi, additional, Baran, David, additional, Balakumaran, Kathir, additional, Scatola, Andrew, additional, Radojevic, Joseph, additional, Gluck, Jason, additional, Arora, Sabeena, additional, Hammond, Jonathan, additional, Ali, Ayyaz, additional, Jennings, Douglas L., additional, and Baker, William L., additional

Published
2021
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36. Air Medical Transport of Patients Diagnosed with Confirmed COVID-19 Infection Undergoing Extracorporeal Membrane Oxygenation (ECMO). A Case Review and Lessons Learned

Author

Bascetta, Thomas, Bolton, Lauri, Kurtzman, Ethan, Hantzos, William, Standish, Heather, Margarido, Patricia, Race, Kathleen, Spencer, John, Baker, William, and Gluck, Jason

Subjects
Article
Abstract

The COVID-19 pandemic disrupted healthcare delivery in every respect, including critical care resources and transport of patients requiring Extracorporeal Membrane Oxygenation (ECMO). Innovative solutions allowing for safe helicopter air transport of these critical patients is needed as ECMO resources are only available in specialty centers. We present a case demonstrating the interfacility collaboration of care for a patient with COVID-19 infection and the lessons learned from the air transport. Careful planning, coordination, communication, and teamwork contributed to the safe transport of this patient, and several others subsequently.

Published
2020

38. Air Medical Transport of Patients Diagnosed With Confirmed Coronavirus Disease 2019 Infection Undergoing Extracorporeal Membrane Oxygenation: A Case Review and Lessons Learned

Author

Bascetta, Thomas, primary, Bolton, Lauri, additional, Kurtzman, Ethan, additional, Hantzos, William, additional, Standish, Heather, additional, Margarido, Patricia, additional, Race, Kathleen, additional, Spencer, John, additional, Baker, William, additional, and Gluck, Jason, additional

Published
2021
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39. COVID-19 in Solid Organ Transplant Recipients: Observations From Connecticut

Author

Kutzler, Heather L., primary, Poulos, Constantine M., additional, Cheema, Faiqa, additional, O’Sullivan, David M., additional, Ali, Ayyaz, additional, Ebcioglu, Zeynep, additional, Einstein, Michael, additional, Feingold, Andrew D., additional, Gluck, Jason, additional, Hammond, Jonathan A., additional, Jaiswal, Abhishek, additional, Lawlor, Michael T., additional, Morgan, Glyn, additional, Radojevic, Joseph A., additional, Rochon, Caroline, additional, Sheiner, Patricia, additional, Singh, Joseph U., additional, Sotil, Eva U., additional, Swales, Colin, additional, Ye, Xiaoyi, additional, and Serrano, Oscar K., additional

Published
2020
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40. Waitlist Mortality and Transplantation in Patients Bridged with Biventricular Devices and Extracorporeal Membrane Oxygenation in the Contemporary Era of Heart Transplantation

Author

Jaiswal, Abhishek, primary, Gadela, Naga Vaishnavi, additional, Azmeen, Ayesha, additional, Gluck, Jason, additional, Radojevic, Joseph, additional, Arora, Sabeena, additional, Hammond, Jonathan, additional, Ali, Ayyaz, additional, Jennings, Douglas, additional, and Baker, William, additional

Published
2020
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42. Differential Short-term Survival in Patients Bridged with Biventricular Devices Versus Extracorporeal Membrane Oxygenation in the Contemporary Era of Heart Transplantation

Author

Baker, William, primary, Gadela, Naga Vaishnavi, additional, Azmeen, Ayesha, additional, Gluck, Jason, additional, Radojevic, Joseph, additional, Arora, Sabeena, additional, Hammond, Jonathan, additional, Ali, Ayyaz, additional, Jennings, Douglas, additional, and Jaiswal, Abhishek, additional

Published
2020
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50. Association Between Time‐in‐Therapeutic Tacrolimus Range and Early Rejection After Heart Transplant

Author

Baker, William L., primary, Steiger, Samantha, additional, Martin, Spencer, additional, Patel, Nirav, additional, Radojevic, Joseph, additional, Darsaklis, Konstadina, additional, O'Bara, Lynn, additional, Kutzler, Heather, additional, Dougherty, James, additional, Feingold, Andrew, additional, Hammond, Jonathan, additional, Fusco, Daniel, additional, and Gluck, Jason A, additional

Published
2019
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