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1. Hypothermia for expanded criteria organ donors in kidney transplantation in France (HYPOREME): a multicentre, randomised controlled trial

Author

Canet, Emmanuel, Brule, Noëlle, Pere, Morgane, Feuillet, Fanny, Blancho, Gilles, Martin-Lefevre, Laurent, Garandeau, Claire, Asehnoune, Karim, Rozec, Bertrand, Duveau, Agnès, Dube, Laurent, Pierrot, Marc, Humbert, Stanislas, Tirot, Patrice, Boyer, Jean-Marc, Labadie, François, Robert, René, Benard, Thierry, Kerforne, Thomas, Thierry, Antoine, Lesieur, Olivier, Vincent, Jean-François, Lesouhaitier, Mathieu, Larmet, Raphaëlle, Vigneau, Cécile, Goepp, Angélique, Bouju, Pierre, Quentin, Charlotte, Egreteau, Pierre-Yves, Huet, Olivier, Renault, Anne, Le Meur, Yannick, Venhard, Jean-Christophe, Buchler, Matthias, Voellmy, Marie-Hélène, Herve, Fabien, Schnell, David, Courte, Anne, Glotz, Denis, Amrouche, Lucile, Hazzan, Marc, Kamar, Nassim, Moal, Valérie, Bourenne, Jérémy, Le Quintrec, Moglie, Morelon, Emmanuel, Kamel, Toufik, Grimbert, Philippe, Heng, Anne-Elisabeth, Merville, Pierre, Garin, Aude, Hiesse, Christian, Fermier, Brice, Mousson, Christiane, Guyot-Colosio, Charlotte, Bouvier, Nicolas, Rerolle, Jean-Philippe, Durrbach, Antoine, Drouin, Sarah, Caillard, Sophie, Frimat, Luc, Girerd, Sophie, Albano, Laetitia, Rostaing, Lionel, Bertrand, Dominique, Hertig, Alexandre, Westeel, Pierre-François, Montini, Florent, Delpierre, Eric, Dorez, Didier, Alamartine, Eric, Ouisse, Carole, Sébille, Véronique, and Reignier, Jean

Published
2024
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2. The genetic landscape and clinical spectrum of nephronophthisis and related ciliopathies

Author

Attié-Bitach, Tania, Comier-Daire, Valerie, Rozet, Jean-Michel, Frishberg, Yaacov, Llanas, Brigitte, Broyer, Michel, Mohsin, Nabil, Macher, Marie-Alice, Philip, Nicole, Baudouin, Véronique, Brackman, Damian, Loirat, Chantal, Charbit, Marina, Dehennault, Maud, Guyot, Claude, Bataille, Pierre, Elting, Mariet, Deschenes, Georges, Gropman, Andrea, Guest, Geneviève, Gagnadoux, Marie-France, Nicoud, Philippe, Cochat, Pierre, Ranchin, Bruno, Bensman, Albert, Guerrot, Anne-Marie, Knebelmann, Bertrand, Bilge, Ilmay, Bruno, Danièle, Burtey, Stéphane, Rouvière, Caroline Rousset, Caudwell, Valérie, Morin, Denis, Dollfus, Hélène, Maisin, Anne, Hamel, Christian, Bieth, Eric, Gie, Sophie, Goodship, Judith, Roussey, Gwenaelle, La Selve, Hermine, Nivet, Hubert, Bessenay, Lucie, Caillez, Mathilde, Palcoux, Jean Bernard, Benoît, Stéphane, Dubot, Philippe, Fila, Marc, Giuliano, Fabienne, Iftene, Daouya, Kessler, Michele, Kwon, Theresa, Lahoche, Anine, Laurent, Audrey, Leclerc, Anne-Laure, Milford, David, Neuhaus, Thomas, Odent, Sylvie, Eckart, Philippe, Chauveau, Dominique, Niaudet, Patrick, Repetto, Horacio, Taque, Sophie, Bruel, Alexandra, Noel-Botte, Alexandra, Launay, Emma Allain, Allard, Lisa, Anlicheau, Dany, Adra, Anne-Laure, Garnier, Arnaud, Nagra, Arvind, Baatard, Remy, Bacchetta, Justine, Sadikoglu, Banu, Barnerias, Christine, Barthelemy, Anne, Basel, Lina, Bassilios, Nader, Ben Maiz, Hedi, Ben Moussa, Fatma, Benmati, Faïza, Berthaud, Romain, Bertholet, Aurélia, Blanchier, Dominique, Boffa, Jean Jacques, Bouchireb, Karim, Bouhabel, Ihab, Boukerroucha, Zakaria, Bourdat-Michel, Guylhène, Boute, Odile, Brochard, Karine, Caumes, Roseline, Elalaoui, Siham Chafai, Chamontin, Bernard, Chastang, Marie Caroline, Pietrement, Christine, Richer, Christine, Legendre, Christophe, Dahan, Karin, Dalla-Vale, Fabienne, Thibaudin, Damien, Dauvergne, Maxime, Davourie, Salandre, Debeukelaer, Martin, Delbet, Jean Daniel, Deltas, Constantinos, Graber, Denis, Devillars, Nadège, Diouf, Boucar, Fenzy, Martine Doco, André, Jean-Luc, Joly, Dominique, Fryer, Alan, Albano, Laetitia, Cassuto, Elisabeth, Pincon, Aline, Medeira, Ana, Chaussenot, Annabelle, Mensire-Marinier, Anne, Bouissou, Francois, Decramer, Stephane, Bottani, Armand, Hummel, Aurélie, Karras, Alexandre, Katz, Avi, Azema, Christine, Janbon, Bénédicte, Roussel, Bernard, Bonniol, Claude, Mariat, Christiophe, Champion, Gérard, Chantreuil, Deborah, Chassaing, Nicolas, Mousson, Christiane, Baudeau, Christine, Cuntz, Delphine Hafdar, Mignot, Cyril, Dehoux, Laurene, Lacombe, Didier, Hannedouche, Thierry, Mérieau, Elodie, Charlin, Emmanuelle, Gauthier, Eric, Plasse, Florent, Faguer, Stanislas, Lebas, Fanny, Demurger, Florence, Emma, Francesco, Cartault, François, Dumont, Geneviève, Godefroid, Nathalie, Guigonis, Vincent, Hillaire, Sophie, Groothoff, Jaap, Dudley, Jan, Jourde-Chiche, Noémie, El Karoui, Khalil, Krid, Saoussen, Coudert, Krier, Bencheick, Larbi, Yver, Laurent, Lavocat, Marie-Pierre, De Sagazan, Le Monies, Leroy, Valerie, Thibaudin, Lise, Ingulli, Liz, Gwanmesia, Lorraine, Burglen, Lydie, Saïd-Menthon, Marie-Hélène, Carrera, Marta, Nizon, Mathilde, Melander, Catherine, Foulard, Michel, Blayo, Monique, Prinseau, Jacques, Jay, Nadine, Brun, Nathalie, Camille, Nicolas, Nobili, François, Devuyst, Olivier, Ben Brahim, Ouafa, Parvex, Paloma, Sabourin, Laurence Perrin, Blanc, Philippe, Vanhille, Philippe, Galichon, Pierre, Pierrepont, Sophie, Planquois, Vincent, Poussard, Gwenaelle, Noble, Claire Pouteil, Allal, Radia, Bernard, Raphaelle, Mounet, Raynaud, Cahen, Rémi, Touraine, Renaud, Rigothier, Claire, Ryckewaert, Amélie, Sacquepee, Mathieu, El Chehadeh, Salima, Samaille, Charlotte, Haq, Shuman, Simckes, Ari, Lanoiselée, Stéphanie, Tellier, Stephanie, Subra, Jean-François, Cloarec, Sylvie, Tenenbam, Julie, Lamy, Thomas, Garraud, Valérie Drouin, Valette, Huguette, Meyssonnier, Vanina, Vargas-Poussou, Rosa, Snajer, Yves, Durault, Sandrine, Plaisier, Emmanuelle, Berard, Etienne, Fakhouri, Fadi, Louillet, Ferielle, Finielz, Paul, Fischbach, Michel, Foliguet, Bernard, Francois-Pradier, Hélène, Garaix, Florentine, Gerard, Marion, Rizzoni, Gianfranco, Gilbert, Brigitte, Glotz, Denis, Dubrasquet, Astrid Godron, Grünfeld, Jean-Pierre, Bollee, Guillaume, Hall, Michelle, Hansson, Sverker, Haye, Damien, Taffin, Hélène, Hildebrandt, Friedhelm, Hourmand, Maryvonne, Kayserili, Hümya, Tack, Ivan, Jacquemont, Marie Line, Fabre-Teste, Jennifer, Kashtan, Cliff, Van Hoeck, Kkoen, Klein, Alexandre, Knefati, Yannick, Knoers, Nine, Konrad, Martin, Lachaux, Alain, Landru, Isabelle, Landthaler, Gilbert, Lang, Philippe, Le Pogamp, Patrick, Legris, Tristan, Didailler, Catherine, Lobbedez, Thierry, de Parscau, Loïc, Pinson, Lucile, Maheut, Hervé, Duval-Arnould, Marc, Rio, Marlène, Gubler, Marie-Claire, Merville, Pierre, Mestrallet, Guillaume, Meunier, Maite, Moreau, Karine, Harambat, Jérôme, Morgan, Graeme, Mourad, Georges, Stuber, Niksic, Boespflug-Tanguy, Odile, Dunand, Olivier, Niel, Olivier, Ouali, Nacera, Malvezzi, Paolo, Jaoude, Pauline Abou, Pelletier, Solenne, Peltier, Julie, Petersen, M.B., Michel, Philippe, Rémy, Philippe, Philit, Jean-Baptiste, Pichault, Valérie, Billette de Villemeur, Thierry, Boudailliez, Bernard, Leheup, Bruno, Dossier, Claire, Djeddi, Djamal-Dine, Berland, Yves, Hurault de Ligny, Bruno, Rigden, Susan, Robino, Christophe, Rossi, Annick, Sarnacki, Sabine, Saidani, Messaoud, Sartorius, Albane Brodin, Schäfer, Elise, Laszlo, Sztriha, Thouret, Marie-Christine, Thuillier-Lecouf, Angélique, Trachtman, Howard, Trivin, Claire, Tsimaratos, Michel, Van Damme-Lombaerts, Rita, Willems, Marjolaine, Youssef, Michel, Zaloszyc, Ariane, Zawodnik, Alexis, Ziliotis, Marie-Julia, Petzold, Friederike, Billot, Katy, Chen, Xiaoyi, Henry, Charline, Filhol, Emilie, Martin, Yoann, Avramescu, Marina, Douillet, Maxime, Morinière, Vincent, Krug, Pauline, Jeanpierre, Cécile, Tory, Kalman, Boyer, Olivia, Burgun, Anita, Servais, Aude, Salomon, Remi, Benmerah, Alexandre, Heidet, Laurence, Garcelon, Nicolas, Antignac, Corinne, Zaidan, Mohamad, and Saunier, Sophie

Published
2023
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5. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M., Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, and Bahram, Seiamak

Published
2022
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6. Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis.

Author

Bouquegneau, Antoine, Loheac, Charlotte, Aubert, Olivier, Bouatou, Yassine, Viglietti, Denis, Empana, Jean-Philippe, Ulloa, Camilo, Murad, Mohammad Hassan, Legendre, Christophe, Glotz, Denis, Jackson, Annette M, Zeevi, Adriana, Schaub, Stephan, Taupin, Jean-Luc, Reed, Elaine F, Friedewald, John J, Tyan, Dolly B, Süsal, Caner, Shapiro, Ron, Woodle, E Steve, Hidalgo, Luis G, O'Leary, Jacqueline, Montgomery, Robert A, Kobashigawa, Jon, Jouven, Xavier, Jabre, Patricia, Lefaucheur, Carmen, and Loupy, Alexandre

Subjects
Humans, Antibodies, HLA Antigens, Complement Activation, Transplantation Immunology, Graft Rejection, Graft Survival, General & Internal Medicine, Medical and Health Sciences
Abstract

BACKGROUND:Anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) are recognized as a major barrier to patients' access to organ transplantation and the major cause of graft failure. The capacity of circulating anti-HLA DSAs to activate complement has been suggested as a potential biomarker for optimizing graft allocation and improving the rate of successful transplantations. METHODS AND FINDINGS:To address the clinical relevance of complement-activating anti-HLA DSAs across all solid organ transplant patients, we performed a meta-analysis of their association with transplant outcome through a systematic review, from inception to January 31, 2018. The primary outcome was allograft loss, and the secondary outcome was allograft rejection. A comprehensive search strategy was conducted through several databases (Medline, Embase, Cochrane, and Scopus). A total of 5,861 eligible citations were identified. A total of 37 studies were included in the meta-analysis. Studies reported on 7,936 patients, including kidney (n = 5,991), liver (n = 1,459), heart (n = 370), and lung recipients (n = 116). Solid organ transplant recipients with circulating complement-activating anti-HLA DSAs experienced an increased risk of allograft loss (pooled HR 3.09; 95% CI 2.55-3.74, P = 0.001; I2 = 29.3%), and allograft rejection (pooled HR 3.75; 95% CI: 2.05-6.87, P = 0.001; I2 = 69.8%) compared to patients without complement-activating anti-HLA DSAs. The association between circulating complement-activating anti-HLA DSAs and allograft failure was consistent across all subgroups and sensitivity analyses. Limitations of the study are the observational and retrospective design of almost all included studies, the higher proportion of kidney recipients compared to other solid organ transplant recipients, and the inclusion of fewer studies investigating allograft rejection. CONCLUSIONS:In this study, we found that circulating complement-activating anti-HLA DSAs had a significant deleterious impact on solid organ transplant survival and risk of rejection. The detection of complement-activating anti-HLA DSAs may add value at an individual patient level for noninvasive biomarker-guided risk stratification. TRIAL REGISTRATION:National Clinical Trial protocol ID: NCT03438058.

Published
2018

7. Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation

Author

Raynaud, Marc, Aubert, Olivier, Reese, Peter P., Bouatou, Yassine, Naesens, Maarten, Kamar, Nassim, Bailly, Élodie, Giral, Magali, Ladrière, Marc, Le Quintrec, Moglie, Delahousse, Michel, Juric, Ivana, Basic-Jukic, Nikolina, Gupta, Gaurav, Akalin, Enver, Yoo, Daniel, Chin, Chen-Shan, Proust-Lima, Cécile, Böhmig, Georg, Oberbauer, Rainer, Stegall, Mark D., Bentall, Andrew J., Jordan, Stanley C., Huang, Edmund, Glotz, Denis, Legendre, Christophe, Montgomery, Robert A., Segev, Dorry L., Empana, Jean-Philippe, Grams, Morgan E., Coresh, Josef, Jouven, Xavier, Lefaucheur, Carmen, and Loupy, Alexandre

Published
2021
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8. 240.1: The Risk of Venous Thromboembolism Is Enhanced After A Cytomegalovirus Infection in Kidney Transplant Recipient

Author

Masset, Christophe, Scemla, Anne, Kerleau, Clarisse, Bressolette, Celine, Le borgne, Florent, Morelon, Emmanuel, Buron, Fanny, Lequintrec-Donnette, Moglie, Perrin, Vincent, Ladrière, Marc, Girerd, Sophie, Legendre, Christophe, Loupy, Alexandre, Sicard, Antoine, Albano, Laetitia, Lefaucheur, Carmen, Glotz, Denis, Mariat, Christophe, Claisse, Guillaume, Dantal, Jacques, and Giral, Magali

Published
2022
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9. Prediction system for risk of allograft loss in patients receiving kidney transplants : international derivation and validation study

Author

Loupy, Alexandre, Aubert, Olivier, Orandi, Babak J, Naesens, Maarten, Bouatou, Yassine, Raynaud, Marc, Divard, Gillian, Jackson, Annette M, Viglietti, Denis, Giral, Magali, Kamar, Nassim, Thaunat, Olivier, Morelon, Emmanuel, Delahousse, Michel, Kuypers, Dirk, Hertig, Alexandre, Rondeau, Eric, Bailly, Elodie, Eskandary, Farsad, Böhmig, Georg, Gupta, Gaurav, Glotz, Denis, Legendre, Christophe, Montgomery, Robert A, Stegall, Mark D, Empana, Jean-Philippe, Jouven, Xavier, Segev, Dorry L, and Lefaucheur, Carmen

Published
2019

10. Safety and efficacy of eculizumab for the prevention of antibody-mediated rejection after deceased-donor kidney transplantation in patients with preformed donor-specific antibodies

Author

Glotz, Denis, Russ, Graeme, Rostaing, Lionel, Legendre, Christophe, Tufveson, Gunnar, Chadban, Steve, Grinyó, Josep, Mamode, Nizam, Rigotti, Paolo, Couzi, Lionel, Büchler, Matthias, Sandrini, Silvio, Dain, Bradley, Garfield, Mary, Ogawa, Masayo, Richard, Tristan, and Marks, William H.

Published
2019
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15. The role of donor hypertension and angiotensin II in the occurrence of early pancreas allograft thrombosis.

Author

Masset, Christophe, Branchereau, Julien, Buron, Fanny, Karam, Georges, Rabeyrin, Maud, Renaudin, Karine, Le Borgne, Florent, Badet, Lionel, Matillon, Xavier, Legendre, Christophe, Glotz, Denis, Antoine, Corinne, Giral, Magali, Dantal, Jacques, and Cantarovich, Diego

Subjects
HOMOGRAFTS, KIDNEY transplantation, ANGIOTENSIN II, RENIN-angiotensin system, PANCREAS, THROMBOSIS, HYPERTENSION
Abstract

Background: About 10-20% of pancreas allografts are still lost in the early postoperative period despite the identification of numerous detrimental risk factors that correlate with graft thrombosis. Methods: We conducted a multicenter study including 899 pancreas transplant recipients between 2000 and 2018. Early pancreas failure due to complete thrombosis, long-term pancreas, kidney and patient survivals were analyzed and adjusted to donor, recipient and perioperative variables using a multivariate cause-specific Cox model stratified to transplant centers. Results: Pancreas from donors with history of hypertension (6.7%), as well as with high body mass index (BMI), were independently associated with an increased risk of pancreas failure within the first 30 post-operative days (respectively, HR= 2.57, 95% CI from 1.35 to 4.89 and HR= 1.11, 95% CI from 1.04 to 1.19). Interaction term between hypertension and BMI was negative. Donor hypertension also impacted long-term pancreas survival (HR= 1.88, 95% CI from 1.13 to 3.12). However, when pancreas survival was calculated after the postoperative day 30, donor hypertension was no longer a significant risk factor (HR= 1.22, 95% CI from 0.47 to 3.15). A lower pancreas survival was observed in patients receiving a pancreas from a hypertensive donor without RAAS (Renin Angiotensin Aldosterone System) blockers compared to others (50% vs 14%, p < 0.001). Pancreas survival was similar among non-hypertensive donors and hypertensive ones under RAAS blockers. Conclusion: Donor hypertension was a significant and independent risk factor of pancreas failure. The well-known pathogenic role of renin-angiotensin-aldosterone system seems to be involved in the genesis of this immediate graft failure. [ABSTRACT FROM AUTHOR]

Published
2024
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16. List of contributors

Author

Adah, Adakole Sylvanus, primary, Allen, Kaitlin, additional, Ambali, Hauwa Motunrayo, additional, Ameen, Soliu Akanni, additional, Aravindan, Sheeja, additional, Azeez, Oyebisi Mistura, additional, Balogun, Rashidat Bolanle, additional, Barreto, André Sales, additional, Basiru, Afisu, additional, Biswas, Chhanda, additional, Boerma, Marjan, additional, Bolaji, Moshood, additional, Cannegieter, Suzanne C., additional, Chatterjee, Shampa, additional, Christofidou-Solomidou, Melpo, additional, DiCarlo, Andrea L., additional, Farid, Alexander R., additional, Fontes, Milene Tavares, additional, Ganguly, Kumkum, additional, Garba, Sirajo, additional, Girão-Silva, Thais, additional, Glotz, Denis, additional, Guo, Xiaohui, additional, Gupta, Madhu, additional, Guzmán-Díaz, Pilar, additional, Kargilis, Daniel C., additional, Kim, Young-Mee, additional, Klein, Diana, additional, Lacchini, Silvia, additional, Lijfering, Willem M., additional, Macedo, Fabricio Nunes, additional, Mayer, Michael M., additional, Miguez, Sofia M., additional, Miranda, Ela María Céspedes, additional, Miyakawa, Ayumi Aurea, additional, Mohan, Sumathy, additional, Mooney, Nuala, additional, Natarajan, Aravindan, additional, Natarajan, Mohan, additional, Olaifa, Folashade Helen, additional, Paul, Oindrila, additional, Pore, Nabendu, additional, Raina, Neha, additional, Rajapakse, Chamith S., additional, Rani, Radha, additional, Rodríguez-Guzmán, Roger, additional, Rosendaal, Frits R., additional, Roy, Sourav, additional, Santana-Filho, Valter Joviniano, additional, Satyamitra, Merriline M., additional, Sertic, F., additional, Shah, Syed Raza, additional, Sielecki, Thais, additional, Tao, Jian Qin, additional, Ushio-Fukai, Masuko, additional, and Vázquez-Medina, José Pablo, additional

Published
2021
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22. The genetic landscape and clinical spectrum of nephronophthisis and related ciliopathies.

Author

Petzold, Friederike, primary, Billot, Katy, additional, Chen, Xiaoyi, additional, Henry, Charline, additional, Filhol, Emilie, additional, Martin, Yoann, additional, Avramescu, Marina, additional, Douillet, Maxime, additional, Morinière, Vincent, additional, Krug, Pauline, additional, Jeanpierre, Cécile, additional, Tory, Kalman, additional, Boyer, Olivia, additional, Burgun, Anita, additional, Servais, Aude, additional, Salomon, Remi, additional, Benmerah, Alexandre, additional, Heidet, Laurence, additional, Garcelon, Nicolas, additional, Antignac, Corinne, additional, Zaidan, Mohamad, additional, Saunier, Sophie, additional, Attié-Bitach, Tania, additional, Comier-Daire, Valerie, additional, Rozet, Jean-Michel, additional, Frishberg, Yaacov, additional, Llanas, Brigitte, additional, Broyer, Michel, additional, Mohsin, Nabil, additional, Macher, Marie-Alice, additional, Philip, Nicole, additional, Baudouin, Véronique, additional, Brackman, Damian, additional, Loirat, Chantal, additional, Charbit, Marina, additional, Dehennault, Maud, additional, Guyot, Claude, additional, Bataille, Pierre, additional, Elting, Mariet, additional, Deschenes, Georges, additional, Gropman, Andrea, additional, Guest, Geneviève, additional, Gagnadoux, Marie-France, additional, Nicoud, Philippe, additional, Cochat, Pierre, additional, Ranchin, Bruno, additional, Bensman, Albert, additional, Guerrot, Anne-Marie, additional, Knebelmann, Bertrand, additional, Bilge, Ilmay, additional, Bruno, Danièle, additional, Burtey, Stéphane, additional, Rouvière, Caroline Rousset, additional, Caudwell, Valérie, additional, Morin, Denis, additional, Dollfus, Hélène, additional, Maisin, Anne, additional, Hamel, Christian, additional, Bieth, Eric, additional, Gie, Sophie, additional, Goodship, Judith, additional, Roussey, Gwenaelle, additional, La Selve, Hermine, additional, Nivet, Hubert, additional, Bessenay, Lucie, additional, Caillez, Mathilde, additional, Palcoux, Jean Bernard, additional, Benoît, Stéphane, additional, Dubot, Philippe, additional, Fila, Marc, additional, Giuliano, Fabienne, additional, Iftene, Daouya, additional, Kessler, Michele, additional, Kwon, Theresa, additional, Lahoche, Anine, additional, Laurent, Audrey, additional, Leclerc, Anne-Laure, additional, Milford, David, additional, Neuhaus, Thomas, additional, Odent, Sylvie, additional, Eckart, Philippe, additional, Chauveau, Dominique, additional, Niaudet, Patrick, additional, Repetto, Horacio, additional, Taque, Sophie, additional, Bruel, Alexandra, additional, Noel-Botte, Alexandra, additional, Launay, Emma Allain, additional, Allard, Lisa, additional, Anlicheau, Dany, additional, Adra, Anne-Laure, additional, Garnier, Arnaud, additional, Nagra, Arvind, additional, Baatard, Remy, additional, Bacchetta, Justine, additional, Sadikoglu, Banu, additional, Barnerias, Christine, additional, Barthelemy, Anne, additional, Basel, Lina, additional, Bassilios, Nader, additional, Ben Maiz, Hedi, additional, Ben Moussa, Fatma, additional, Benmati, Faïza, additional, Berthaud, Romain, additional, Bertholet, Aurélia, additional, Blanchier, Dominique, additional, Boffa, Jean Jacques, additional, Bouchireb, Karim, additional, Bouhabel, Ihab, additional, Boukerroucha, Zakaria, additional, Bourdat-Michel, Guylhène, additional, Boute, Odile, additional, Brochard, Karine, additional, Caumes, Roseline, additional, Elalaoui, Siham Chafai, additional, Chamontin, Bernard, additional, Chastang, Marie Caroline, additional, Pietrement, Christine, additional, Richer, Christine, additional, Legendre, Christophe, additional, Dahan, Karin, additional, Dalla-Vale, Fabienne, additional, Thibaudin, Damien, additional, Dauvergne, Maxime, additional, Davourie, Salandre, additional, Debeukelaer, Martin, additional, Delbet, Jean Daniel, additional, Deltas, Constantinos, additional, Graber, Denis, additional, Devillars, Nadège, additional, Diouf, Boucar, additional, Fenzy, Martine Doco, additional, André, Jean-Luc, additional, Joly, Dominique, additional, Fryer, Alan, additional, Albano, Laetitia, additional, Cassuto, Elisabeth, additional, Pincon, Aline, additional, Medeira, Ana, additional, Chaussenot, Annabelle, additional, Mensire-Marinier, Anne, additional, Bouissou, Francois, additional, Decramer, Stephane, additional, Bottani, Armand, additional, Hummel, Aurélie, additional, Karras, Alexandre, additional, Katz, Avi, additional, Azema, Christine, additional, Janbon, Bénédicte, additional, Roussel, Bernard, additional, Bonniol, Claude, additional, Mariat, Christiophe, additional, Champion, Gérard, additional, Chantreuil, Deborah, additional, Chassaing, Nicolas, additional, Mousson, Christiane, additional, Baudeau, Christine, additional, Cuntz, Delphine Hafdar, additional, Mignot, Cyril, additional, Dehoux, Laurene, additional, Lacombe, Didier, additional, Hannedouche, Thierry, additional, Mérieau, Elodie, additional, Charlin, Emmanuelle, additional, Gauthier, Eric, additional, Plasse, Florent, additional, Faguer, Stanislas, additional, Lebas, Fanny, additional, Demurger, Florence, additional, Emma, Francesco, additional, Cartault, François, additional, Dumont, Geneviève, additional, Godefroid, Nathalie, additional, Guigonis, Vincent, additional, Hillaire, Sophie, additional, Groothoff, Jaap, additional, Dudley, Jan, additional, Jourde-Chiche, Noémie, additional, El Karoui, Khalil, additional, Krid, Saoussen, additional, Coudert, Krier, additional, Bencheick, Larbi, additional, Yver, Laurent, additional, Lavocat, Marie-Pierre, additional, De Sagazan, Le Monies, additional, Leroy, Valerie, additional, Thibaudin, Lise, additional, Ingulli, Liz, additional, Gwanmesia, Lorraine, additional, Burglen, Lydie, additional, Saïd-Menthon, Marie-Hélène, additional, Carrera, Marta, additional, Nizon, Mathilde, additional, Melander, Catherine, additional, Foulard, Michel, additional, Blayo, Monique, additional, Prinseau, Jacques, additional, Jay, Nadine, additional, Brun, Nathalie, additional, Camille, Nicolas, additional, Nobili, François, additional, Devuyst, Olivier, additional, Ben Brahim, Ouafa, additional, Parvex, Paloma, additional, Sabourin, Laurence Perrin, additional, Blanc, Philippe, additional, Vanhille, Philippe, additional, Galichon, Pierre, additional, Pierrepont, Sophie, additional, Planquois, Vincent, additional, Poussard, Gwenaelle, additional, Noble, Claire Pouteil, additional, Allal, Radia, additional, Bernard, Raphaelle, additional, Mounet, Raynaud, additional, Cahen, Rémi, additional, Touraine, Renaud, additional, Rigothier, Claire, additional, Ryckewaert, Amélie, additional, Sacquepee, Mathieu, additional, El Chehadeh, Salima, additional, Samaille, Charlotte, additional, Haq, Shuman, additional, Simckes, Ari, additional, Lanoiselée, Stéphanie, additional, Tellier, Stephanie, additional, Subra, Jean-François, additional, Cloarec, Sylvie, additional, Tenenbam, Julie, additional, Lamy, Thomas, additional, Drouin Garraud, Valérie, additional, Valette, Huguette, additional, Meyssonnier, Vanina, additional, Vargas-Poussou, Rosa, additional, Snajer, Yves, additional, Durault, Sandrine, additional, Plaisier, Emmanuelle, additional, Berard, Etienne, additional, Fakhouri, Fadi, additional, Louillet, Ferielle, additional, Finielz, Paul, additional, Fischbach, Michel, additional, Foliguet, Bernard, additional, Francois-Pradier, Hélène, additional, Garaix, Florentine, additional, Gerard, Marion, additional, Rizzoni, Gianfranco, additional, Gilbert, Brigitte, additional, Glotz, Denis, additional, Dubrasquet, Astrid Godron, additional, Grünfeld, Jean-Pierre, additional, Bollee, Guillaume, additional, Hall, Michelle, additional, Hansson, Sverker, additional, Haye, Damien, additional, Taffin, Hélène, additional, Hildebrandt, Friedhelm, additional, Hourmand, Maryvonne, additional, Kayserili, Hümya, additional, Tack, Ivan, additional, Jacquemont, Marie Line, additional, Fabre-Teste, Jennifer, additional, Kashtan, Cliff, additional, Van Hoeck, Kkoen, additional, Klein, Alexandre, additional, Knefati, Yannick, additional, Knoers, Nine, additional, Konrad, Martin, additional, Lachaux, Alain, additional, Landru, Isabelle, additional, Landthaler, Gilbert, additional, Lang, Philippe, additional, Le Pogamp, Patrick, additional, Legris, Tristan, additional, Didailler, Catherine, additional, Lobbedez, Thierry, additional, de Parscau, Loïc, additional, Pinson, Lucile, additional, Maheut, Hervé, additional, Duval-Arnould, Marc, additional, Rio, Marlène, additional, Gubler, Marie-Claire, additional, Merville, Pierre, additional, Mestrallet, Guillaume, additional, Meunier, Maite, additional, Moreau, Karine, additional, Harambat, Jérôme, additional, Morgan, Graeme, additional, Mourad, Georges, additional, Stuber, Niksic, additional, Boespflug-Tanguy, Odile, additional, Dunand, Olivier, additional, Niel, Olivier, additional, Ouali, Nacera, additional, Malvezzi, Paolo, additional, Abou Jaoude, Pauline, additional, Pelletier, Solenne, additional, Peltier, Julie, additional, Petersen, M.B., additional, Michel, Philippe, additional, Rémy, Philippe, additional, Philit, Jean-Baptiste, additional, Pichault, Valérie, additional, Billette de Villemeur, Thierry, additional, Boudailliez, Bernard, additional, Leheup, Bruno, additional, Dossier, Claire, additional, Djeddi, Djamal-Dine, additional, Berland, Yves, additional, Hurault de Ligny, Bruno, additional, Rigden, Susan, additional, Robino, Christophe, additional, Rossi, Annick, additional, Sarnacki, Sabine, additional, Saidani, Messaoud, additional, Sartorius, Albane Brodin, additional, Schäfer, Elise, additional, Laszlo, Sztriha, additional, Thouret, Marie-Christine, additional, Thuillier-Lecouf, Angélique, additional, Trachtman, Howard, additional, Trivin, Claire, additional, Tsimaratos, Michel, additional, Van Damme-Lombaerts, Rita, additional, Willems, Marjolaine, additional, Youssef, Michel, additional, Zaloszyc, Ariane, additional, Zawodnik, Alexis, additional, and Ziliotis, Marie-Julia, additional

Published
2023
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26. Long term outcomes of transplantation using kidneys from expanded criteria donors : prospective, population based cohort study

Author

Aubert, Olivier, Kamar, Nassim, Vernerey, Dewi, Viglietti, Denis, Martinez, Frank, Duong-Van-Huyen, Jean-Paul, Eladari, Dominique, Empana, Jean-Philippe, Rabant, Marion, Verine, Jerome, Rostaing, Lionel, Congy, Nicolas, Guilbeau-Frugier, Céline, Mourad, Georges, Garrigue, Valérie, Morelon, Emmanuel, Giral, Magali, Kessler, Michèle, Ladrière, Marc, Delahousse, Michel, Glotz, Denis, Legendre, Christophe, Jouven, Xavier, Lefaucheur, Carmen, and Loupy, Alexandre

Published
2015

33. Effect of sirolimus on malignancy and survival after kidney transplantation : systematic review and meta-analysis of individual patient data

Author

Knoll, Greg A, Kokolo, Madzouka B, Mallick, Ranjeeta, Beck, Andrew, Buenaventura, Chieny D, Ducharme, Robin, Barsoum, Rashad, Bernasconi, Corrado, Blydt-Hansen, Tom D, Ekberg, Henrik, Felipe, Claudia R, Firth, John, Gallon, Lorenzo, Gelens, Marielle, Glotz, Denis, Gossmann, Jan, Guba, Markus, Morsy, Ahmed Ali, Salgo, Rebekka, Scheuermann, Earnst H, Tedesco-Silva, Helio, Vitko, Stefan, Watson, Christopher, and Fergusson, Dean A

Published
2014

39. Pratique de la biopsie rénale : résultat d’une enquête en France, revue de la littérature et recommandations

Author

Bollée, Guillaume, Moulin, Bruno, Martinez, Frank, Meulders, Quentin, Rougier, Jean-Philippe, Baumelou, Alain, Glotz, Denis, Subra, Jean-François, Ulinski, Tim, Vrigneaud, Laurence, Brasseur, José, Alhenc-Gelas, Martine, Martin, Laurent, Daniel, Laurent, Kourilsky, Olivier, Deteix, Patrice, Sie, Pierre, Ronco, Pierre, and Houillier, Pascal

Published
2012
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41. Proposed Definitions of Antibody-Mediated Rejection for Use as a Clinical Trial Endpoint in Kidney Transplantation

Author

Roufosse, Candice, primary, Becker, Jan Ulrich, additional, Rabant, Marion, additional, Seron, Daniel, additional, Bellini, Maria Irene, additional, Böhmig, Georg A., additional, Budde, Klemens, additional, Diekmann, Fritz, additional, Glotz, Denis, additional, Hilbrands, Luuk, additional, Loupy, Alexandre, additional, Oberbauer, Rainer, additional, Pengel, Liset, additional, Schneeberger, Stefan, additional, and Naesens, Maarten, additional

Published
2022
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42. Proposed Definitions of T Cell-Mediated Rejection and Tubulointerstitial Inflammation as Clinical Trial Endpoints in Kidney Transplantation

Author

Seron, Daniel, primary, Rabant, Marion, additional, Becker, Jan Ulrich, additional, Roufosse, Candice, additional, Bellini, Maria Irene, additional, Böhmig, Georg A., additional, Budde, Klemens, additional, Diekmann, Fritz, additional, Glotz, Denis, additional, Hilbrands, Luuk, additional, Loupy, Alexandre, additional, Oberbauer, Rainer, additional, Pengel, Liset, additional, Schneeberger, Stefan, additional, and Naesens, Maarten, additional

Published
2022
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43. Surrogate Endpoints for Late Kidney Transplantation Failure

Author

Naesens, Maarten, primary, Budde, Klemens, additional, Hilbrands, Luuk, additional, Oberbauer, Rainer, additional, Bellini, Maria Irene, additional, Glotz, Denis, additional, Grinyó, Josep, additional, Heemann, Uwe, additional, Jochmans, Ina, additional, Pengel, Liset, additional, Reinders, Marlies, additional, Schneeberger, Stefan, additional, and Loupy, Alexandre, additional

Published
2022
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44. Rationale for Surrogate Endpoints and Conditional Marketing Authorization of New Therapies for Kidney Transplantation

Author

Naesens, Maarten, primary, Loupy, Alexandre, additional, Hilbrands, Luuk, additional, Oberbauer, Rainer, additional, Bellini, Maria Irene, additional, Glotz, Denis, additional, Grinyó, Josep, additional, Heemann, Uwe, additional, Jochmans, Ina, additional, Pengel, Liset, additional, Reinders, Marlies, additional, Schneeberger, Stefan, additional, and Budde, Klemens, additional

Published
2022
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46. Proposed Definitions of T Cell-Mediated Rejection and Tubulointerstitial Inflammation as Clinical Trial Endpoints in Kidney Transplantation

Author

Seron, Daniel, Rabant, Marion, Becker, Jan Ulrich, Roufosse, Candice, Bellini, Maria Irene, Boehmig, Georg A., Budde, Klemens, Diekmann, Fritz, Glotz, Denis, Hilbrands, Luuk, Loupy, Alexandre, Oberbauer, Rainer, Pengel, Liset, Schneeberger, Stefan, Naesens, Maarten, Seron, Daniel, Rabant, Marion, Becker, Jan Ulrich, Roufosse, Candice, Bellini, Maria Irene, Boehmig, Georg A., Budde, Klemens, Diekmann, Fritz, Glotz, Denis, Hilbrands, Luuk, Loupy, Alexandre, Oberbauer, Rainer, Pengel, Liset, Schneeberger, Stefan, and Naesens, Maarten

Abstract

The diagnosis of acute T cell-mediated rejection (aTCMR) after kidney transplantation has considerable relevance for research purposes. Its definition is primarily based on tubulointerstitial inflammation and has changed little over time; aTCMR is therefore a suitable parameter for longitudinal data comparisons. In addition, because aTCMR is managed with antirejection therapies that carry additional risks, anxieties, and costs, it is a clinically meaningful endpoint for studies. This paper reviews the history and classifications of TCMR and characterizes its potential role in clinical trials: a role that largely depends on the nature of the biopsy taken (indication vs protocol), the level of inflammation observed (e.g., borderline changes vs full TCMR), concomitant chronic lesions (chronic active TCMR), and the therapeutic intervention planned. There is ongoing variability-and ambiguity-in clinical monitoring and management of TCMR. More research, to investigate the clinical relevance of borderline changes (especially in protocol biopsies) and effective therapeutic strategies that improve graft survival rates with minimal patient morbidity, is urgently required. The present paper was developed from documentation produced by the European Society for Organ Transplantation (ESOT) as part of a Broad Scientific Advice request that ESOT submitted to the European Medicines Agency for discussion in 2020. This paper proposes to move toward refined definitions of aTCMR and borderline changes to be included as primary endpoints in clinical trials of kidney transplantation.

Published
2022

47. Proposed Definitions of Antibody-Mediated Rejection for Use as a Clinical Trial Endpoint in Kidney Transplantation

Author

Roufosse, Candice, Becker, Jan Ulrich, Rabant, Marion, Seron, Daniel, Bellini, Maria Irene, Boehmig, Georg A., Budde, Klemens, Diekmann, Fritz, Glotz, Denis, Hilbrands, Luuk, Loupy, Alexandre, Oberbauer, Rainer, Pengel, Liset, Schneeberger, Stefan, Naesens, Maarten, Roufosse, Candice, Becker, Jan Ulrich, Rabant, Marion, Seron, Daniel, Bellini, Maria Irene, Boehmig, Georg A., Budde, Klemens, Diekmann, Fritz, Glotz, Denis, Hilbrands, Luuk, Loupy, Alexandre, Oberbauer, Rainer, Pengel, Liset, Schneeberger, Stefan, and Naesens, Maarten

Abstract

Antibody-mediated rejection (AMR) is caused by antibodies that recognize donor human leukocyte antigen (HLA) or other targets. As knowledge of AMR pathophysiology has increased, a combination of factors is necessary to confirm the diagnosis and phenotype. However, frequent modifications to the AMR definition have made it difficult to compare data and evaluate associations between AMR and graft outcome. The present paper was developed following a Broad Scientific Advice request from the European Society for Organ Transplantation (ESOT) to the European Medicines Agency (EMA), which explored whether updating guidelines on clinical trial endpoints would encourage innovations in kidney transplantation research. ESOT considers that an AMR diagnosis must be based on a combination of histopathological factors and presence of donor-specific HLA antibodies in the recipient. Evidence for associations between individual features of AMR and impaired graft outcome is noted for microvascular inflammation scores >= 2 and glomerular basement membrane splitting of > 10% of the entire tuft in the most severely affected glomerulus. Together, these should form the basis for AMR-related endpoints in clinical trials of kidney transplantation, although modifications and restrictions to the Banff diagnostic definition of AMR are proposed for this purpose. The EMA provided recommendations based on this Broad Scientific Advice request in December 2020; further discussion, and consensus on the restricted definition of the AMR endpoint, is required.

Published
2022

48. Rationale for Surrogate Endpoints and Conditional Marketing Authorization of New Therapies for Kidney Transplantation

Author

Naesens, Maarten, Loupy, Alexandre, Hilbrands, Luuk, Oberbauer, Rainer, Bellini, Maria Irene, Glotz, Denis, Grinyó, Josep, Heemann, Uwe, Jochmans, Ina, Pengel, Liset, Reinders, Marlies, Schneeberger, Stefan, Budde, Klemens, Naesens, Maarten, Loupy, Alexandre, Hilbrands, Luuk, Oberbauer, Rainer, Bellini, Maria Irene, Glotz, Denis, Grinyó, Josep, Heemann, Uwe, Jochmans, Ina, Pengel, Liset, Reinders, Marlies, Schneeberger, Stefan, and Budde, Klemens

Abstract

Conditional marketing authorization (CMA) facilitates timely access to new drugs for illnesses with unmet clinical needs, such as late graft failure after kidney transplantation. Late graft failure remains a serious, burdensome, and life-threatening condition for recipients. This article has been developed from content prepared by members of a working group within the European Society for Organ Transplantation (ESOT) for a Broad Scientific Advice request, submitted by ESOT to the European Medicines Agency (EMA), and reviewed by the EMA in 2020. The article presents the rationale for using surrogate endpoints in clinical trials aiming at improving late graft failure rates, to enable novel kidney transplantation therapies to be considered for CMA and improve access to medicines. The paper also provides background data to illustrate the relationship between primary and surrogate endpoints. Developing surrogate endpoints and a CMA strategy could be particularly beneficial for studies where the use of primary endpoints would yield insufficient statistical power or insufficient indication of long-term benefit following transplantation.

Published
2022

49. Surrogate Endpoints for Late Kidney Transplantation Failure

Author

Naesens, Maarten, Budde, Klemens, Hilbrands, Luuk, Oberbauer, Rainer, Bellini, Maria Irene, Glotz, Denis, Grinyó, Josep, Heemann, Uwe, Jochmans, Ina, Pengel, Liset, Reinders, Marlies, Schneeberger, Stefan, Loupy, Alexandre, Naesens, Maarten, Budde, Klemens, Hilbrands, Luuk, Oberbauer, Rainer, Bellini, Maria Irene, Glotz, Denis, Grinyó, Josep, Heemann, Uwe, Jochmans, Ina, Pengel, Liset, Reinders, Marlies, Schneeberger, Stefan, and Loupy, Alexandre

Abstract

In kidney transplant recipients, late graft failure is often multifactorial. In addition, primary endpoints in kidney transplantation studies seek to demonstrate the short-term efficacy and safety of clinical interventions. Although such endpoints might demonstrate short-term improvement in specific aspects of graft function or incidence of rejection, such findings do not automatically translate into meaningful long-term graft survival benefits. Combining many factors into a well-validated model is therefore more likely to predict long-term outcome and better reflect the complexity of late graft failure than using single endpoints. If conditional marketing authorization could be considered for therapies that aim to improve long-term outcomes following kidney transplantation, then the surrogate endpoint for graft failure in clinical trial settings needs clearer definition. This Consensus Report considers the potential benefits and drawbacks of several candidate surrogate endpoints (including estimated glomerular filtration rate, proteinuria, histological lesions, and donor-specific anti-human leukocyte antigen antibodies) and composite scoring systems. The content was created from information prepared by a working group within the European Society for Organ Transplantation (ESOT). The group submitted a Broad Scientific Advice request to the European Medicines Agency (EMA), June 2020: the request focused on clinical trial design and endpoints in kidney transplantation. Following discussion and refinement, the EMA made final recommendations to ESOT in December 2020 regarding the potential to use surrogate endpoints in clinical studies that aim to improving late graft failure.

Published
2022

50. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

Süsal, Caner, Carapito, Raphael; Aouadi, Ismail; Verniquet, Martin; Untrau, Meiggie; Pichot, Angelique; Beaudrey, Thomas; Bassand, Xavier; Meyer, Sebastien; Faucher, Loic; Posson, Juliane; Morlon, Aurore; Kotova, Irina; Delbos, Florent; Walencik, Alexandre; Aarnink, Alice; Kennel, Anne; Suberbielle, Caroline; Taupin, Jean-Luc; Matern, Benedict M.; Spierings, Eric; Congy-Jolivet, Nicolas; Essaydi, Arnaud; Perrin, Peggy; Blancher, Antoine; Charron, Dominique; Cereb, Nezih; Maumy-Bertrand, Myriam; Bertrand, Frederic; Garrigue, Valerie; Pernin, Vincent; Weekers, Laurent; Naesens, Maarten; Kamar, Nassim; Legendre, Christophe; Glotz, Denis; Caillard, Sophie; Ladriere, Marc; Giral, Magali; Anglicheau, Dany; Bahram, Seiamak, School of Medicine, Süsal, Caner, Carapito, Raphael; Aouadi, Ismail; Verniquet, Martin; Untrau, Meiggie; Pichot, Angelique; Beaudrey, Thomas; Bassand, Xavier; Meyer, Sebastien; Faucher, Loic; Posson, Juliane; Morlon, Aurore; Kotova, Irina; Delbos, Florent; Walencik, Alexandre; Aarnink, Alice; Kennel, Anne; Suberbielle, Caroline; Taupin, Jean-Luc; Matern, Benedict M.; Spierings, Eric; Congy-Jolivet, Nicolas; Essaydi, Arnaud; Perrin, Peggy; Blancher, Antoine; Charron, Dominique; Cereb, Nezih; Maumy-Bertrand, Myriam; Bertrand, Frederic; Garrigue, Valerie; Pernin, Vincent; Weekers, Laurent; Naesens, Maarten; Kamar, Nassim; Legendre, Christophe; Glotz, Denis; Caillard, Sophie; Ladriere, Marc; Giral, Magali; Anglicheau, Dany; Bahram, Seiamak, and School of Medicine

Abstract

The identity of histocompatibility loci, besides human leukocyte antigen (HLA), remains elusive. The major histocompatibility complex (MHC) class I MICA gene is a candidate histocompatibility locus. Here, we investigate its role in a French multicenter cohort of 1,356 kidney transplants. MICA mismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45-3.11; P < 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) were strongly associated with increased antibody-mediated rejection (ABMR) (HR, 3.79; 95% CI: 1.94-7.39; P < 0.001; HR, 9.92; 95% CI: 7.43-13.20; P < 0.001, respectively). This effect was synergetic with that of anti-HLA DSA before and after transplantation (HR, 25.68; 95% CI: 3.31-199.41; P = 0.002; HR, 82.67; 95% CI: 33.67-202.97; P < 0.001, respectively). De novo-developed anti-MICA DSA were the most harmful because they were also associated with reduced graft survival (HR, 1.29; 95% CI: 1.05-1.58; P = 0.014). Finally, the damaging effect of anti-MICA DSA on graft survival was confirmed in an independent cohort of 168 patients with ABMR (HR, 1.71; 95% CI: 1.02-2.86; P = 0.041). In conclusion, assessment of MICA matching and immunization for the identification of patients at high risk for transplant rejection and loss is warranted., ‘Laboratoire d’Excellence’ (LabEx) TRANSPLANTEX; IdEx Unistra; SFRI-STRAT’US; INSERM; European Union (EU); European Regional Development Fund; INTERREG V Program; France’s National Research Agency (Agence Nationale de Recherche; ANR); Investment for the Future Program (Programme des Investissements d’Avenir; PIA); Strasbourg’s Interdisciplinary Thematic Institute (ITI) for Precision Medicine; TRANSPLANTEX NG; ITI 2021–2028 Program of the University of Strasbourg; CNRS; Institut Universitaire de France (IUF); Fédération Hospitalo-Universitaire (FHU) OMICARE; MSD Avenir ‘Autogen’

Published
2022

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