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1. Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

Author

Jesús F. Bermejo-Martin, Milagros González-Rivera, Raquel Almansa, Dariela Micheloud, Ana P. Tedim, Marta Domínguez-Gil, Salvador Resino, Marta Martín-Fernández, Pablo Ryan Murua, Felipe Pérez-García, Luis Tamayo, Raúl Lopez-Izquierdo, Elena Bustamante, César Aldecoa, José Manuel Gómez, Jesús Rico-Feijoo, Antonio Orduña, Raúl Méndez, Isabel Fernández Natal, Gregoria Megías, Montserrat González-Estecha, Demetrio Carriedo, Cristina Doncel, Noelia Jorge, Alicia Ortega, Amanda de la Fuente, Félix del Campo, José Antonio Fernández-Ratero, Wysali Trapiello, Paula González-Jiménez, Guadalupe Ruiz, Alyson A. Kelvin, Ali Toloue Ostadgavahi, Ruth Oneizat, Luz María Ruiz, Iria Miguéns, Esther Gargallo, Ioana Muñoz, Sara Pelegrin, Silvia Martín, Pablo García Olivares, Jamil Antonio Cedeño, Tomás Ruiz Albi, Carolina Puertas, Jose Ángel Berezo, Gloria Renedo, Rubén Herrán, Juan Bustamante-Munguira, Pedro Enríquez, Ramón Cicuendez, Jesús Blanco, Jesica Abadia, Julia Gómez Barquero, Nuria Mamolar, Natalia Blanca-López, Luis Jorge Valdivia, Belén Fernández Caso, María Ángeles Mantecón, Anna Motos, Laia Fernandez-Barat, Ricard Ferrer, Ferrán Barbé, Antoni Torres, Rosario Menéndez, José María Eiros, and David J. Kelvin

Subjects
SARS-CoV-2, Cytokine, Sepsis, COVID-19, Plasma, Rnaemia, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or viral RNA load in plasma is associated with severe COVID-19 and also to this dysregulated response. Methods A total of 250 patients with COVID-19 were recruited (50 outpatients, 100 hospitalized ward patients and 100 critically ill). Viral RNA detection and quantification in plasma was performed using droplet digital PCR, targeting the N1 and N2 regions of the SARS-CoV-2 nucleoprotein gene. The association between SARS-CoV-2 RNAemia and viral RNA load in plasma with severity was evaluated by multivariate logistic regression. Correlations between viral RNA load and biomarkers evidencing dysregulation of host response were evaluated by calculating the Spearman correlation coefficients. Results The frequency of viral RNAemia was higher in the critically ill patients (78%) compared to ward patients (27%) and outpatients (2%) (p

Published
2020
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2. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author

Cabello, María Aguilar, Alcaraz-Serrano, Victoria, Aldecoa, Cesar, Alegre, Cynthia, Calderón, Ángela Algaba, Álvarez, Sergio, Ruiz, Antonio Álvarez, Andrea, Ruth, Aparicio, Maria de Alba, Arrieta, Marta, Ayestarán, J. Ignacio, Badia, Joan Ramon, Badía, Mariona, Pravia, Orville Báez, Mariño, Ana Balan, Balsera, Begoña, Barbena, Laura, Barbeta, Enric, Bardi, Tommaso, Segade, Patricia Barral, Barroso, Marta, García, José Ángel Berezo, Bermejo, Jesus, Bigas, Judit, Blancas, Rafael, Cortés, María Luisa Blasco, Saera, María Bodi, Bofill, Neus, Vieiro, María Teresa Bouza, Bueno, Leticia, Bustamante-Munguira, Juan, Martínez, Cecilia del Busto, Hermoso, David Campi, Fernández, Sandra Campos, Cano, Iosune, Canseco, Joan, Fernández, Pablo Cardinal, García, Laura Carrión, Carvalho, Sulamita, Castellà, Manuel, Castellví, Andrea, Castro, Pedro, Centelles-Serrano, María José, Ávila, Ramon Cicuendez, Cillóniz, Catia, Clar, Luisa, Climent, Cristina, Codina, Jordi, Conde, Pamela, Contreras, Sofía, Parra, Raul de Frutos, Sánchez, Raul de Pablo, Mendoza, Diego De, Díaz, Yolanda, Vilas, María Digna Rivas, Moreno, Cristina Dólera, Dot, Irene, Giraudo, Pedro Enríquez, Arijón, Inés Esmorís, Monjo, Teresa Farre, Fernández, Javier, Ferrando, Carlos, Figueras, Albert, Espina, Lorena Forcelledo, Franquesa, Enric, Furro, Àngels, Gabarrus, Albert, Galbán, Cristóbal, García, Felipe, García, Beatriz, Prieto, Emilio García, Redruello, Carlos García, Sagastume, Amaia García, Castillo, Maria Luisa Gascón, Gomà, Gemma, Casal, Vanesa Gómez, Gómez, Silvia, Gonzalez, Carmen Gómez, Gordo, Federico, Gracia, Maria Pilar, Fernández, María José Gutierrez, Herraiz, Alba, Herrán-Monge, Rubén, Ibarz, Mercedes, Iglesias, Silvia, Janer, Maria Teresa, Jiménez, Gabriel, Díaz, Mar Juan, Kiarostami, Karsa, Álvarez, Juan I. Lazo, León, Miguel, López-Gavín, Alexandre, Guerrero, Desiree Macias, Herrera, Nuria Mamolar, Mendiluce, Rafael Mañez, Mantellini, Cecilia L., Naya, Gregorio Marco, Barcos, Iris Marco, Marcos, Pilar, Peis, Enrique Marmol, Cuadrado, Marta Martín, Delgado, María Cruz Martin, Vicente, Paula Martín, Martínez, María, Fernández, Carmen Eulalia Martínez, Juan, Maria Dolores Martínez, Palacios, Basilisa Martínez, Jimenez, Juan Fernando Masa, Masclans, Joan Ramon, Maseda, Emilio, Fernández, Eva María Menor, Banderas, Priscila Metora, Minguez, Olga, Miralbés, Mar, Monclou, Josman, Montejo-González, Juan Carlos, Montserrat, Neus, Aznar, María Mora, Morales, Dulce, Cano, Sara Guadalupe Moreno, Rodríguez, David Mosquera, Muñoz-Bermúdez, Rosana, Nicolás, José María, Bou, Ramon Nogue, Salinas, Rafaela Nogueras, Ocón, Marta, Ortega, Ana, Ossa, Sergio, Pagliarani, Pablo, Parrilla, Francisco, Pedregosa-Díaz, José, Bastida, Leire Pérez, Pérez, Purificación, Pérez-García, Felipe, Planelles, Gloria Pérez, Rubio, Eva Pérez, Laguna, David Pestaña, Prados, Javier, Pujol, Andrés, Coll, Núria Ramon, Sanchez-Giron, Gloria Renedo, Roche-Campo, Ferran, Rodriguez, Laura, Castro, Felipe Rodríguez de, Rodríguez, Silvia, Ruiz, Covadonga Rodríguez, Rubio, Jorge, López, Alberto Rubio, Ruiz-García, Ángela Leonor, Miralles, Miriam Ruiz, Murúa, Pablo Ryan, Paz, Eva Saborido, Degracia, Ana Salazar, Sanchez, Miguel, Sánchez, Ana, Chinesta, Susana Sancho, Santacoloma, Bitor, Sariñena, Maria Teresa, Pensado, Marta Segura, Serra, Lidia, Serra-Fortuny, Mireia, Lázaro, Ainhoa Serrano, Servià, Lluís, Soliva, Laura, Speziale, Carla, Tormos, Adrián, Torres, Mateu, Tranque-Liberal, Celia, Trefler, Sandra, Trujillano, Javier, Vaca, Rafaela, Val, Estela, Ruiz, Luis Valdivia, Vallverdú, Montserrat, Martin-Montalvo, Maria Van der Hofstadt, Adrio, Sabela Vara, Vázquez, Nil, Vengoechea, Javier, Vilà-Vilardel, Clara, Vilanova, Judit, Warrington, Tatiana Villada, Yang, Hua, Yang, Minlan, Zapatero, Ana, González, Jessica, de Batlle, Jordi, Benítez, Iván D., Torres, Gerard, Santisteve, Sally, Targa, Adriano D.S., Gort-Paniello, Clara, Moncusí-Moix, Anna, Aguilà, Maria, Seck, Fatty, Ceccato, Adrián, Ferrer, Ricard, Motos, Anna, Riera, Jordi, Fernández, Laia, Menéndez, Rosario, Lorente, José Ángel, Peñuelas, Oscar, Garcia-Gasulla, Dario, Peñasco, Yhivian, Ricart, Pilar, Abril Palomares, Elena, Aguilera, Luciano, Rodríguez, Alejandro, Boado Varela, Maria Victoria, Beteré, Belén, Pozo-Laderas, Juan Carlos, Solé-Violan, Jordi, Salvador-Adell, Inmaculada, Novo, Mariana Andrea, Barberán, José, Amaya Villar, Rosario, Garnacho-Montero, José, Gómez, José M., Blandino Ortiz, Aaron, Tamayo Lomas, Luis, Úbeda, Alejandro, Catalán-González, Mercedes, Sánchez-Miralles, Angel, Martínez Varela, Ignacio, Jorge García, Ruth Noemí, Franco, Nieves, Gumucio-Sanguino, Víctor D., Bustamante-Munguira, Elena, Valdivia, Luis Jorge, Caballero, Jesús, Gallego, Elena, Rodríguez, Covadonga, Castellanos-Ortega, Álvaro, Trenado, Josep, Marin-Corral, Judith, Albaiceta, Guillermo M., de la Torre, Maria del Carmen, Loza-Vázquez, Ana, Vidal, Pablo, Añón, Jose M., Carbajales Pérez, Cristina, Sagredo, Victor, Carbonell, Nieves, Socias, Lorenzo, Barberà, Carme, Estella, Angel, Diaz, Emili, de Gonzalo-Calvo, David, Torres, Antoni, and Barbé, Ferran

Published
2023
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3. Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality?

Author

Servia-Goixart, Lluís, Trujillano-Cabello, Javier, Escobar-Ortiz, Joan, Montserrat-Ortiz, Neus, Zapata-Rojas, Amalia, Grau-Carmona, Teodoro, Bautista-Redondo, Iris, Cruz-Ramos, Ana, Diaz-Castellanos, Laura, Morales-Cifuentes, Miriam, Bono, Montserrat Plaza, Montejo-Gonzalez, Juan Carlos, Temprano-Vazquez, Susana, Arjona-Diaz, Veronica, Garcia-Fuentes, Carlos, Mudarra-Reche, Carolina, Orejana-Martin, Maria, Lopez-Delgado, Juan Carlos, Lores-Obradors, Africa, Anguela-Calvet, Laura, Muñoz-Del Río, Gloria, Revelo-Esquibel, Pamela Alejandra, Alanez-Saavedra, Henry, Serra-Paya, Pau, Luna-Solis, Stephani Maria, Salinas-Canovas, Alvaro, De Frutos-Seminario, Fernando, Rodriguez-Queralto, Oriol, Gonzalez-Iglesias, Carlos, Zamora-Elson, Monica, Fuente-O'Connor, Eugenia de la, Arbeloa, Carlos Seron, Bueno-Vidales, Nestor, Iglesias-Rodriguez, Rayden, Martin-Luengo, Ana, Sanchez-Miralles, Angel, Marmol-Peis, Enrique, Ruiz-Miralles, Miriam, Gonzalez-Sanz, Maria, Server-Martinez, Arantzazu, Vila-Garcia, Belen, Lorencio-Cardenas, Carol, Macaya-Redin, Laura, Flecha-Viguera, Raquel, Aldunate-Calvo, Sara, Flordelis-Lasierra, Jose Luis, Rio, Irene Jimenez-del, Mampaso-Recio, Jose Ramon, Rodriguez-Roldan, Jose Manuel, Gastaldo-Simeon, Rosa, Gimenez-Castellanos, Josefina, Fernandez-Ortega, Juan Francisco, Martinez-Carmona, Juan F., Lopez-Luque, Esther, Ortega-Ordiales, Ane, Crespo-Gomez, Monica, Ramirez-Montero, Victor, Lopez-García, Esther, Navarro-Lacalle, Arturo, Martinez-Garcia, Pilar, Dominguez-Fernandez, Maria Inmaculada, Vera-Artazcoz, Paula, Izura-Gomez, Marta, Hernandez-Duran, Susana, Bordeje-Laguna, M<ce:sup loc='post">a</ce:sup> Luisa, Mor-Marco, Esther, Rovira-Valles, Yaiza, Philibert, Viridiana, Alcazar-Espin, Maravillas de las Nieves, Higon-Cañigral, Aurea, Calvo-Herranz, Enrique, Manzano-Moratinos, Diego, Portugal-Rodriguez, Esther, Andaluz-Ojeda, David, Parra-Morais, Laura, Citores-Gonzalez, Rafael, Garcia-Gonzalez, Maria Teresa, Sanchez-Giron, Gloria Renedo, Navas-Moya, Elisabeth, Ferrer-Pereto, Carles, Lluch-Candal, Cristina, Ruiz-Izquierdo, Jessica, Castor-Bekari, Silvia, Leon-Cinto, Cristina, Martinez de Lagran, Itziar, Yebenes-Reyes, Juan Carlos, Nieto-Martino, Beatriz, Vaquerizo-Alonso, Clara, Almanza-Lopez, Susana, Perez-Quesada, Sonia, Anton-Pascual, Jose Luis, Marin-Corral, Judith, Sistachs-Baquedano, Maite, Hacer-Puig, Maria, Picornell-Noguera, Marina, Mateu-Campos, Lidon, Martinez-Valero, Clara, Ortiz-Suñer, Andrea, Llorente-Ruiz, Beatriz, Martinez-Diaz, María Cristina, Muñoz De La Peña, Maria Trascasa, Rodriguez-Serrano, Diego Anibal, Fernandez-Salvatierra, Leticia, Barcelo-Castello, Mireia, Millan-Taratiel, Paula, Tejada-Artigas, Antonio, Martinez-Arroyo, Ines, Araujo-Aguilar, Pilar, Fuster-Cabre, Maria, Andres-Gines, Laura, Soldado-Olmo, Sonia, Menor-Fernandez, Eva Mª, Lage-Cendon, Lucas, Touceda-Bravo, Alberto, Sanchez-Ales, Laura, Almorin-Gonzalvez, Laura, Gero-Escapa, Maria, Martinez-Barrio, Esther, Ossa-Echeverri, Sergio, Monge-Donaire, Diana, Lopez-Delgado, Juan C., Bordeje-Laguna, M Luisa, Montejo-Gonzalez, Juan C., Martinez-Carmona, Juan Francisco, Flordelis-Lasierra, José L., Menor-Fernández, Eva M., Martínez de Lagrán, Itziar, and Yebenes-Reyes, Juan C.

Published
2022
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4. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author

Jessica González, Jordi de Batlle, Iván D. Benítez, Gerard Torres, Sally Santisteve, Adriano D.S. Targa, Clara Gort-Paniello, Anna Moncusí-Moix, Maria Aguilà, Fatty Seck, Adrián Ceccato, Ricard Ferrer, Anna Motos, Jordi Riera, Laia Fernández, Rosario Menéndez, José Ángel Lorente, Oscar Peñuelas, Dario Garcia-Gasulla, Yhivian Peñasco, Pilar Ricart, Elena Abril Palomares, Luciano Aguilera, Alejandro Rodríguez, Maria Victoria Boado Varela, Belén Beteré, Juan Carlos Pozo-Laderas, Jordi Solé-Violan, Inmaculada Salvador-Adell, Mariana Andrea Novo, José Barberán, Rosario Amaya Villar, José Garnacho-Montero, José M. Gómez, Aaron Blandino Ortiz, Luis Tamayo Lomas, Alejandro Úbeda, Mercedes Catalán-González, Angel Sánchez-Miralles, Ignacio Martínez Varela, Ruth Noemí Jorge García, Nieves Franco, Víctor D. Gumucio-Sanguino, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesús Caballero, Elena Gallego, Covadonga Rodríguez, Álvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M. Albaiceta, Maria del Carmen de la Torre, Ana Loza-Vázquez, Pablo Vidal, Jose M. Añón, Cristina Carbajales Pérez, Victor Sagredo, Nieves Carbonell, Lorenzo Socias, Carme Barberà, Angel Estella, Emili Diaz, David de Gonzalo-Calvo, Antoni Torres, Ferran Barbé, María Aguilar Cabello, Victoria Alcaraz-Serrano, Cesar Aldecoa, Cynthia Alegre, Ángela Algaba Calderón, Sergio Álvarez, Antonio Álvarez Ruiz, Ruth Andrea, Maria de Alba Aparicio, Marta Arrieta, J. Ignacio Ayestarán, Joan Ramon Badia, Mariona Badía, Orville Báez Pravia, Ana Balan Mariño, Begoña Balsera, Laura Barbena, Enric Barbeta, Tommaso Bardi, Patricia Barral Segade, Marta Barroso, José Ángel Berezo García, Jesus Bermejo, Judit Bigas, Rafael Blancas, María Luisa Blasco Cortés, María Bodi Saera, Neus Bofill, María Teresa Bouza Vieiro, Leticia Bueno, Juan Bustamante-Munguira, Cecilia del Busto Martínez, David Campi Hermoso, Sandra Campos Fernández, Iosune Cano, Joan Canseco, Pablo Cardinal Fernández, Laura Carrión García, Sulamita Carvalho, Manuel Castellà, Andrea Castellví, Pedro Castro, María José Centelles-Serrano, Ramon Cicuendez Ávila, Catia Cillóniz, Luisa Clar, Cristina Climent, Jordi Codina, Pamela Conde, Sofía Contreras, Raul de Frutos Parra, Raul de Pablo Sánchez, Diego De Mendoza, Yolanda Díaz, María Digna Rivas Vilas, Cristina Dólera Moreno, Irene Dot, Pedro Enríquez Giraudo, Inés Esmorís Arijón, Teresa Farre Monjo, Javier Fernández, Carlos Ferrando, Albert Figueras, Lorena Forcelledo Espina, Enric Franquesa, Àngels Furro, Albert Gabarrus, Cristóbal Galbán, Felipe García, Beatriz García, Emilio García Prieto, Carlos García Redruello, Amaia García Sagastume, Maria Luisa Gascón Castillo, Gemma Gomà, Vanesa Gómez Casal, Silvia Gómez, Carmen Gómez Gonzalez, Federico Gordo, Maria Pilar Gracia, María José Gutierrez Fernández, Alba Herraiz, Rubén Herrán-Monge, Mercedes Ibarz, Silvia Iglesias, Maria Teresa Janer, Gabriel Jiménez, Mar Juan Díaz, Karsa Kiarostami, Juan I. Lazo Álvarez, Miguel León, Alexandre López-Gavín, Desiree Macias Guerrero, Nuria Mamolar Herrera, Rafael Mañez Mendiluce, Cecilia L. Mantellini, Gregorio Marco Naya, Iris Marco Barcos, Pilar Marcos, Enrique Marmol Peis, Marta Martín Cuadrado, María Cruz Martin Delgado, Paula Martín Vicente, María Martínez, Carmen Eulalia Martínez Fernández, Maria Dolores Martínez Juan, Basilisa Martínez Palacios, Juan Fernando Masa Jimenez, Joan Ramon Masclans, Emilio Maseda, Eva María Menor Fernández, Priscila Metora Banderas, Olga Minguez, Mar Miralbés, Josman Monclou, Juan Carlos Montejo-González, Neus Montserrat, María Mora Aznar, Dulce Morales, Sara Guadalupe Moreno Cano, David Mosquera Rodríguez, Rosana Muñoz-Bermúdez, José María Nicolás, Ramon Nogue Bou, Rafaela Nogueras Salinas, Marta Ocón, Ana Ortega, Sergio Ossa, Pablo Pagliarani, Francisco Parrilla, José Pedregosa-Díaz, Leire Pérez Bastida, Purificación Pérez, Felipe Pérez-García, Gloria Pérez Planelles, Eva Pérez Rubio, David Pestaña Laguna, Javier Prados, Andrés Pujol, Núria Ramon Coll, Gloria Renedo Sanchez-Giron, Ferran Roche-Campo, Laura Rodriguez, Felipe Rodríguez de Castro, Silvia Rodríguez, Covadonga Rodríguez Ruiz, Jorge Rubio, Alberto Rubio López, Ángela Leonor Ruiz-García, Miriam Ruiz Miralles, Pablo Ryan Murúa, Eva Saborido Paz, Ana Salazar Degracia, Miguel Sanchez, Ana Sánchez, Susana Sancho Chinesta, Bitor Santacoloma, Maria Teresa Sariñena, Marta Segura Pensado, Lidia Serra, Mireia Serra-Fortuny, Ainhoa Serrano Lázaro, Lluís Servià, Laura Soliva, Carla Speziale, Adrián Tormos, Mateu Torres, Celia Tranque-Liberal, Sandra Trefler, Javier Trujillano, Rafaela Vaca, Estela Val, Luis Valdivia Ruiz, Montserrat Vallverdú, Maria Van der Hofstadt Martin-Montalvo, Sabela Vara Adrio, Nil Vázquez, Javier Vengoechea, Clara Vilà-Vilardel, Judit Vilanova, Tatiana Villada Warrington, Hua Yang, Minlan Yang, and Ana Zapatero

Subjects
Pulmonary and Respiratory Medicine
Published
2023

5. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Roberto Lorusso, Maria Elena De Piero, Silvia Mariani, Michele Di Mauro, Thierry Folliguet, Fabio Silvio Taccone, Luigi Camporota, Justyna Swol, Dominik Wiedemann, Mirko Belliato, Lars Mikael Broman, Alain Vuylsteke, Yigal Kassif, Anna Mara Scandroglio, Vito Fanelli, Philippe Gaudard, Stephane Ledot, Julian Barker, Udo Boeken, Sven Maier, Alexander Kersten, Bart Meyns, Matteo Pozzi, Finn M Pedersen, Peter Schellongowski, Kaan Kirali, Nicholas Barrett, Jordi Riera, Thomas Mueller, Jan Belohlavek, Valeria Lo Coco, Iwan C C Van der Horst, Bas C T Van Bussel, Ronny M Schnabel, Thijs Delnoij, Gil Bolotin, Luca Lorini, Martin O Schmiady, David Schibilsky, Mariusz Kowalewski, Luis F Pinto, Pedro E Silva, Igor Kornilov, Aaron Blandino Ortiz, Leen Vercaemst, Simon Finney, Peter P Roeleveld, Matteo Di Nardo, Felix Hennig, Marta Velia Antonini, Mark Davidson, Tim J Jones, Thomas Staudinger, Peter Mair, Juliane Kilo, Christoph Krapf, Kathrin Erbert, Andreas Peer, Nikolaos Bonaros, Florian Kotheletner, Niklas Krenner Mag, Liana Shestakova, Greet Hermans, Dieter Dauwe, Philippe Meersseman, Bernard Stockman, Leda Nobile, Olivier Lhereux, Alexandre Nrasseurs, Jacques Creuter, Daniel De Backer, Simone Giglioli, Gregoire Michiels, Pierre Foulon, Matthias Raes, Inez Rodrigus, Matthias Allegaert, Philippe Jorens, Gerd Debeucklare, Michael Piagnerelli, Patrick Biston, Harlinde Peperstraete, Komeel Vandewiele, Olivier Germay, Dimitri Vandeweghe, Sven Havrin, Marc Bourgeois, Marc-Gilbert Lagny, Genette Alois, Nathalie Lavios, Benoit Misset, Romain Courcelle, Philippe J Timmermans, Alaaddin Yilmaz, Michiel Vantomout, Jerone Lehaen, Ame Jassen, Herbert Guterman, Maarten Strauven, Piet Lormans, Bruno Verhamme, catherine Vandewaeter, Frederik Bonte, Dominique Vionne, Martin Balik, Jan Blàha, Michal Lips, Michal Othal, Filip Bursa, Radim Spacek, Steffen Christensen, Vibeke Jorgensen, Marc Sorensen, Soren A Madsen, Severin Puss, Aleksandr Beljantsev, gabriel Saiydoun, Antonio Fiore, Pascal Colson, Florian Bazalgette, Xavier Capdevila, Sebastien Kollen, Laurent Muller, Jean-Francois Obadia, Pierre-Yves Dubien, Lucrezia Ajrhourh, Pierre G Guinot, Jonathan Zarka, Patricia Besserve, Maximilian V Malfertheiner, Esther Dreier, Birgit Heinze, Payam Akhyari, Artur Lichtenberg, Hug Aubin, Alexander Assman, Diyar Saeed, Holger Thiele, Matthias Baumgaertel, Jan D Schmitto, Natanov Ruslan, Axel Haverich, Matthias Thielmann, Thorsten Brenner, Arjang Ruhpawar, Christoph Benk, Martin Czerny, Dawid L Staudacher, Fridhelm Beyersdorf, Johannes Kalbhenn, Philipp Henn, Aron-Frederik Popov, Torje Iuliu, Ralf Muellenbach, Christian Reyher, Caroline Rolfes, Gosta Lotz, Michael Sonntagbauer, Helen Winkels, Julia Fichte, Robert Stohr, Sebastian Kalverkamp, Christian Karagiannidis, Simone Schafer, Alexei Svetlitchny, Hans-Bernd Hopf, Dominik Jarczak, Heinirich Groesdonk, Magdalena Rommer, Jan Hirsch, Christian Kaehny, Dimitros Soufleris, Georgios Gavriilidis, Kostantinos Pontikis, Magdalini Kyriakopoulou, Anna Kyriakoudi, Serena O'Brien, Ian Conrick-Martin, Edmund Carton, Maged Makhoul, Josef Ben-Ari, Amir Hadash, Alexander Kogan, Reut Kassif Lerner, Anas Abu-Shakra, Moshe Matan, Ahmad Balawona, Erez Kachel, Roman Altshuler, Ori Galante, Lior Fuchs, Yaniv Almog, Yaron S Ishay, Yael Lichter, Amir Gal-oz, Uri Carmi, Asaph Nini, Arie Soroksky, Hagi Dekel, Ziv Rozman, Emad Tayem, Eduard Ilgiyaev, Yuval Hochman, daniel Miltau, Avigal Rapoport, Arieh Eden, Dmitry Kompanietz, Michael Yousif, Miri Golos, Lorenzo Grazioli, Davide Ghitti, Antonio Loforte, Daniela Di Luca, Massimo Baiocchi, Davide Pacini, Antioco Cappai, Paolo Meani, Michele Mondino, Claudio F Russo, Marco Ranucci, Dario Fina, Marco Cotza, Andrea Ballotta, Giovanni Landoni, Pasquale Nardelli, Eygeny V Fominski, Luca Brazzi, Giorgia Montrucchio, Gabriele Sales, Umberto Simonetti, Sergio Livigni, Daniela Silengo, Giulia Arena, Stefania S Sovatzis, Antonella Degani, Mariachiara Riccardi, Elisa Milanesi, Giuseppe Raffa, Gennaro Martucci, Antonio Arcadipane, Giovanna Panarello, Giovanni Chiarini, Sergio Cattaneo, Carmine Puglia, Stefano Benussi, Giuseppe Foti, Marco Giani, Michela Bombino, Maria Cristina Costa, Roberto Rona, Leonello Avalli, Abele Donati, Roberto Carozza, Francesco Gasparri, Andrea Carsetti, Marco Picichè, Anna Marinello, Vinicio Danzi, Anita Zanin, Ignazio Condello, Flavio Fiore, Marco Moscarelli, Giuseppe Nasso, Giuseppe Speziale, Luca Sandrelli, Andrea Montalto, Francesco Musumeci, Alessandro Circelli, Emanuele Russo, Vanni Agnoletti, Ruggero Rociola, Aldo D Milano, Emanuele Pilato, Giuseppe Comentale, Andrea Montisci, Francesco Alessandri, Antonella Tosi, Francesco Pugliese, Giovanni Giordano, Simone Carelli, Domenico L Grieco, Antonio M Dell'Anna, Massimo Antonelli, Enrico Ramoni, Josè Zulueta, Mauro Del Giglio, Sebastiano Petracca, Pietro Bertini, Fabio Guarracino, Luigi De Simone, Paolo M Angeletti, Francesco Forfori, Francesco Taraschi, Veronica N Quintiliani, Robertas Samalavicius, Agne Jankuviene, Nadezda Scupakova, Karolis Urbonas, Juozas Kapturauskas, Gro Soerensen, Piotr Suwalski, Luis Linhares Santos, Ana Marques, Marisa Miranda, Sonia Teixeira, Andrea Salgueiro, Filipe Pereira, Michail Ketskalo, Sergey Tsarenko, Alexandra Shilova, Ivan Afukov, Konstantin Popugaev, Sergei Minin, Daniil Shelukhin, Olga Malceva, Moroz Gleb, Alexander Skopets, Roman Kornelyuk, Alexandr Kulikov, Vadim Okhrimchuk, Alexandr Turchaninov, Maxim Petrushin, Anastasia Sheck, Akhmed Mekulov, Svetlana Ciryateva, Dmitry Urusov, Vojka Gorjup, Alenka Golicnik, Tomaz Goslar, Ricard Ferrer, Maria Martinez-Martinez, Eduard Argudo, Neiser Palmer, Raul De Pablo Sanchez, Lucas Juan Higuera, Lucas Arnau Blasco, Josè A Marquez, Fabrizio Sbraga, Mari Paz Fuset, Pablo Ruiz De Gopegui, Luis M Claraco, Josè A De Ayala, Maranta Peiro, Pilar Ricart, Sergio Martinez, Fernando Chavez, Marc Fabra, elena Sandoval, David Toapanta, Albert Carraminana, Adrian Tellez, Jeysson Ososio, Pablo Milan, Jorge Rodriguez, Garcia Andoni, Carola Gutierrez, Enrique Perez de la Sota, Andrea Eixeres-Esteve, Maria Teresa Garcia-Maellas, Judit Gutierrez-Gutierrez, Rafael Arboleda-Salazar, Patricia Santa Teresa, Alexis Jaspe, Alberto Garrido, Galo Castaneda, Sara Alcantara, Nuria Martinez, Marina Perez, Hector Villanueva, Anxela Vidal Gonzalez, Juan Paez, Arnoldo Santon, Cesar Perez, Marta Lopez, Maria Isabel Rubio Lopez, Antonio Gordillo, Jose Naranjo-Izurieta, Javier Munoz, Immaculada Alcalde, Fernando Onieva, Ricardo Gimeno Costa, Francisco Perez, Isabel Madrid, Monica Gordon, Carlos L Albacete Moreno, Daniel Perez, Nayara Lopez, Domingo Martinenz, Pablo Blanco-Schweizer, Cristina Diez, David Perez, Ana Prieto, Gloria Renedo, Elena Bustamante, Ramon Cicuendez, Rafael Citores, Victoria Boado, Katherine Garcia, Roberto Voces, Monica Domezain, Jose Maria Nunez Martinez, Raimundo Vicente, David Martin, Antonio Andreu, Vanesa Gomez Casal, Ignacio Chico, Eva Maria Menor, Sabela Vara, Jose Gamacho, Helen Perez-Chomon, Francisco Javier Gonzales, Irene Barrero, Luis Martin-Villen, Esperanza Fernandez, Maria Mendoza, Joaquin Navarro, Joaquin Colomina Climent, Alfredo Gonzales-Perez, Guillermo Muniz-Albaceita, Laura Amado, Raquel Rodriguez, Emilio Ruiz, Maria Eiras, Edgars Grins, Rosen Magnus, Mikael Kanetoft, Marcus Eidevald, Pia Watson, Paul R Vogt, Peter Steiger, Tobias Aigner, Alberto Weber, Jurg Grunefelder, Martin Kunz, Martin Grapow, Thierry Aymard, Diana Reser, Gianluca Agus, Jolanda Consiglio, Matthias Haenggi, Jenni Hansjoerg, Manuela Iten, Thomas Doeble, Urs Zenklusen, Xavier Bechtold, Giovanni Faedda, Manuel Iafrate, Amanda Rohjer, Layla Bergamaschi, Jos Maessen, Dinis Reis Miranda, H Endeman, D Gommers, C Meuwese, Jacinta Maas, MJ Van Gijlswijk, RN Van Berg, Dario Candura, Marcel Van der Linden, Merijin Kant, JJ Van der Heijden, Eric Scholten, Nicole Van Belle-van Haren, WK Lagrand, Alexander P Vlaar, Syste De Jong, Basar Cander, Murat Sargin, Murat Ugur, Mehmet A Kaygin, Kathleen Daly, Nicola Agnew, Laura Head, Laura Kelly, Gunawardena Anoma, Clare Russell, Verna Aquino, Ian Scott, Lucy Flemming, Stuart Gillon, Olivia Moore, Elton Gelandt, George Auzinger, Sameer Patel, Robert Loveridge, MUMC+: MA Cardiothoracale Chirurgie (3), CTC, RS: Carim - V04 Surgical intervention, University of Zurich, and Lorusso, Roberto

Subjects
Pulmonary and Respiratory Medicine, 2740 Pulmonary and Respiratory Medicine, 610 Medicine & health, 10023 Institute of Intensive Care Medicine
Abstract

BACKGROUND: Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with COVID-19, but uncertainty remains about the determinants of in-hospital mortality and data on post-discharge outcomes are scarce. The aims of this study were to investigate the variables associated with in-hospital outcomes in patients who received ECMO during the first wave of COVID-19 and to describe the status of patients 6 months after ECMO initiation.METHODS: EuroECMO-COVID is a prospective, multicentre, observational study developed by the European Extracorporeal Life Support Organization. This study was based on data from patients aged 16 years or older who received ECMO support for refractory COVID-19 during the first wave of the pandemic-from March 1 to Sept 13, 2020-at 133 centres in 21 countries. In-hospital mortality and mortality 6 months after ECMO initiation were the primary outcomes. Mixed-Cox proportional hazards models were used to investigate associations between patient and management-related variables (eg, patient demographics, comorbidities, pre-ECMO status, and ECMO characteristics and complications) and in-hospital deaths. Survival status at 6 months was established through patient contact or institutional charts review. This study is registered with ClinicalTrials.gov, NCT04366921, and is ongoing.FINDINGS: Between March 1 and Sept 13, 2020, 1215 patients (942 [78%] men and 267 [22%] women; median age 53 years [IQR 46-60]) were included in the study. Median ECMO duration was 15 days (IQR 8-27). 602 (50%) of 1215 patients died in hospital, and 852 (74%) patients had at least one complication. Multiorgan failure was the leading cause of death (192 [36%] of 528 patients who died with available data). In mixed-Cox analyses, age of 60 years or older, use of inotropes and vasopressors before ECMO initiation, chronic renal failure, and time from intubation to ECMO initiation of 4 days or more were associated with higher in-hospital mortality. 613 patients did not die in hospital, and 547 (95%) of 577 patients for whom data were available were alive at 6 months. 102 (24%) of 431 patients had returned to full-time work at 6 months, and 57 (13%) of 428 patients had returned to part-time work. At 6 months, respiratory rehabilitation was required in 88 (17%) of 522 patients with available data, and the most common residual symptoms included dyspnoea (185 [35%] of 523 patients) and cardiac (52 [10%] of 514 patients) or neurocognitive (66 [13%] of 512 patients) symptoms.INTERPRETATION: Patient's age, timing of cannulation (FUNDING: None.

Published
2023

6. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Cillóniz, Catia, primary, Motos, Anna, additional, Castañeda, Tatiana, additional, Gabarrús, Albert, additional, Barbé, Ferran, additional, Torres, Antoni, additional, Gumucio-Sanguino, Víctor D., additional, Mañez, Rafael, additional, Solé-Violan, Jordi, additional, de Castro, Felipe Rodríguez, additional, Suarez-Sipmann, Fernando, additional, García, Ruth Noemí Jorge, additional, Aznar, María Mora, additional, Torres, Mateu, additional, Martinez, María, additional, Alegre, Cynthia, additional, Riera, Jordi, additional, Contreras, Sofía, additional, Pericas, Juan Manuel, additional, Ferrer, Ricard, additional, Caballero, Jesús, additional, Trujillano, Javier, additional, Vallverdú, Montse, additional, León, Miguel, additional, Badía, Mariona, additional, Balsera, Begoña, additional, Servià, Lluís, additional, Vilanova, Judit, additional, Rodríguez, Silvia, additional, Montserrat, Neus, additional, Iglesias, Silvia, additional, Prados, Javier, additional, Carvalho, Sula, additional, Miralbés, Mar, additional, Monclou, Josman, additional, Jiménez, Gabriel, additional, Codina, Jordi, additional, Val, Estela, additional, Pagliarani, Pablo, additional, Rubio, Jorge, additional, Morales, Dulce, additional, Pujol, Andrés, additional, Furro, Àngels, additional, García, Beatriz, additional, Torres, Gerard, additional, Vengoechea, Javier, additional, Gonzalo-Calvo, David de, additional, González, Jessica, additional, Gomez, Silvia, additional, Gómez, José M., additional, Franco, Nieves, additional, Barberán, José, additional, Albaiceta, Guillermo M, additional, Espina, Lorena Forcelledo, additional, Prieto, Emilio García, additional, Vicente, Paula Martín, additional, del Busto Martínez, Cecilia, additional, Vidal-Cortés, Pablo, additional, Garmendia, José Luis García, additional, Cabello, María Aguilar, additional, Fernández, Carmen Eulalia Martínez, additional, Carbonell, Nieves, additional, Cortés, María Luisa Blasco, additional, Lázaro, Ainhoa Serrano, additional, Díaz, Mar Juan, additional, Ortiz, Aaron Blandino, additional, Menendez, Rosario, additional, Valdivia, Luis Jorge, additional, Boado, María Victoria, additional, Chinesta, Susana Sancho, additional, del Carmen de la Torre, Maria, additional, Varela, Ignacio Martínez, additional, Vieiro, María Teresa Bouza, additional, Arijón, Inés Esmorís, additional, Hermoso, David Campi, additional, Salinas, Rafaela Nogueras, additional, Monjo, Teresa Farre, additional, Bou, Ramon Nogue, additional, Naya, Gregorio Marco, additional, Barberà, Carme, additional, Coll, Núria Ramon, additional, Catalán-González, Mercedes, additional, Montejo-González, Juan Carlos, additional, Sanchez-Giron, Gloria Renedo, additional, Bustamante-Munguira, Juan, additional, Bustamante-Munguira, Elena, additional, Avila, Ramon Cicuendez, additional, Herrera, Nuria Mamolar, additional, Almansa, Raquel, additional, Ortega, Alicia, additional, Bermejo-Martin, Jesús, additional, Sagredo, Víctor, additional, Añon, Jose, additional, Agrifoglio, Alexander, additional, Cachafeiro, Lucia, additional, Maseda, Emilio, additional, Socias, Lorenzo, additional, Novo, Mariana Andrea, additional, Figueras, Albert, additional, Janer, Maria Teresa, additional, Soliva, Laura, additional, Ocón, Marta, additional, Clar, Luisa, additional, Ayestarán, J Ignacio, additional, Peñasco, Yhivian, additional, Fernández, Sandra Campos, additional, Serra-Fortuny, Mireia, additional, Forcadell-Ferreres, Eva, additional, Salvador-Adell, Immaculada, additional, Bofill, Neus, additional, Adell-Serrano, Berta, additional, Díaz, Josep Pedregosa, additional, Casacuberta-Barberà, Núria, additional, Urrelo-Cerrón, Luis, additional, Piñol-Tena, Àngels, additional, Roche-Campo, Ferran, additional, de la Gándara, Amalia Martínez, additional, Murúa, Pablo Ryan, additional, Ruíz, Covadonga Rodríguez, additional, García, Laura Carrión, additional, Álvarez, Juan I Lazo, additional, Lorente, José Ángel, additional, Loza-Vázquez, Ana, additional, Guerrero, Desire Macias, additional, Huerta, Arturo, additional, Tognetti, Daniel, additional, Redruello, Carlos García, additional, Rodríguez, David Mosquera, additional, Fernández, Eva María Menor, additional, Adrio, Sabela Vara, additional, Casal, Vanesa Gómez, additional, Pensado, Marta Segura, additional, Vilas, María Digna Rivas, additional, Sagastume, Amaia García, additional, de Pablo Sánchez, Raul, additional, Laguna, David Pestaña, additional, Bardi, Tommaso, additional, Villar, Rosario Amaya, additional, Gonzalez, Carmen Gómez, additional, Castillo, Maria Luisa Gascón, additional, Garnacho-Montero, José, additional, Cantón-Bulnes, María Luisa, additional, Marin-Corral, Judith, additional, Pérez, Cristina Carbajales, additional, Masclans, Joan Ramon, additional, Degracia, Ana Salazar, additional, Bigas, Judit, additional, Muñoz-Bermúdez, Rosana, additional, Vilà-Vilardel, Clara, additional, Parrilla, Francisco, additional, Dot, Irene, additional, Zapatero, Ana, additional, Díaz, Yolanda, additional, Gracia, María Pilar, additional, Pérez, Purificación, additional, Castellví, Andrea, additional, Climent, Cristina, additional, Serra, Lidia, additional, Barbena, Laura, additional, Cano, Iosune, additional, Ricart, Pilar, additional, Herraiz, Alba, additional, Marcos, Pilar, additional, Rodríguez, Laura, additional, Sariñena, Maria Teresa, additional, Sánchez, Ana, additional, Úbeda, Alejandro, additional, Delgado, María Cruz Martin, additional, Gallego, Elena, additional, Jimenez, Juan Fernando Masa, additional, Gomà, Gemma, additional, Díaz, Emi, additional, Ibarz, Mercedes, additional, De Mendoza, Diego, additional, Barbeta, Enric, additional, Alcaraz-Serrano, Victoria, additional, Badia, Joan Ramon, additional, Castella, Manuel, additional, Bueno, Leticia, additional, Ceccato, Adrian, additional, Palomeque, Andrea, additional, Barat, Laia Fernandez, additional, Cillóniz, Catia, additional, Conde, Pamela, additional, Fernández, Javier, additional, Gabarrus, Albert, additional, Kiarostami, Karsa, additional, López-Gavín, Alexandre, additional, Mantellini, Cecilia L, additional, Speziale, Carla, additional, Vázquez, Nil, additional, Yang, Hua, additional, Yang, Minlan, additional, Ferrando, Carlos, additional, Castro, Pedro, additional, Arrieta, Marta, additional, Nicolas, Jose Maria, additional, Andrea, Rut, additional, Barroso, Marta, additional, Pérez, Raquel, additional, Álvarez, Sergio, additional, Garcia-Gasulla, Dario, additional, Tormos, Adrián, additional, Lomas, Luis Tamayo, additional, Aldecoa, Cesar, additional, Herrán-Monge, Rubén, additional, García, José Ángel Berezo, additional, Giraudo, Pedro Enríquez, additional, Fernández, Pablo Cardinal, additional, López, Alberto Rubio, additional, Pravia, Orville Báez, additional, Messa, Juan López, additional, Bastida, Leire Pérez, additional, Ruiz, Antonjo Alvarez, additional, Trenado, José, additional, Pous, Anna Parera, additional, Galbán, Cristóbal, additional, Lago, Ana López, additional, Paz, Eva Saborido, additional, Segade, Patricia Barral, additional, Mariño, Ana Balan, additional, Mendez, Manuel Valledor, additional, de Frutos, Raúl, additional, Aguilera, Luciano, additional, Pérez-García, Felipe, additional, López-Ramos, Esther, additional, Ruiz-García, Ángela Leonor, additional, Beteré, Belén, additional, Blancas, Rafael, additional, Dólera, Cristina, additional, Planelles, Gloria Perez, additional, Peis, Enrique Marmol, additional, Juan, Maria Dolores Martinez, additional, Miralles, Miriam Ruiz, additional, Rubio, Eva Perez, additional, Martin-Montalvo, Maria Van der Hofstadt, additional, Sánchez-Miralles, Ángel, additional, Warrington, Tatiana Villada, additional, Pozo-Laderas, Juan Carlos, additional, Estrella, Angel, additional, Cano, Sara Guadalupe Moreno, additional, Gordo, Federico, additional, Palacios, Basilisa Martinez, additional, Nieto, Maite, additional, Nieto, Maria Teresa, additional, Ossa, Sergio, additional, Ortega, Ana, additional, Sanchez, Miguel, additional, and Santacoloma, Bitor, additional

Published
2023
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7. Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Author

Jesús F Bermejo-Martin, Nadia García-Mateo, Anna Motos, Salvador Resino, Luis Tamayo, Pablo Ryan Murua, Elena Bustamante-Munguira, Elena Gallego Curto, Alejandro Úbeda-Iglesias, María del Carmen de la Torre, Ángel Estella, Sandra Campos-Fernández, Ignacio Martínez Varela, Felipe Pérez-García, Lorenzo Socias, Juan López Messa, Pablo Vidal-Cortés, Víctor Sagredo Meneses, Milagros González-Rivera, Nieves Carbonell, David de Gonzalo-Calvo, María Cruz Martín Delgado, Luis Jorge Valdivia, Caridad Martín-López, Ruth Noemí Jorge García, Emilio Maseda, Ana Loza-Vázquez, David J Kelvin, Ferrán Barbé, Antoni Torres, Alicia Ortega, Amanda de la Fuente, Raquel Almansa, Tamara Postigo, Noelia Jorge, Ana P Tedim, Laura González-González, Lara Sánchez Recio, Wysali Trapiello, José Ángel Berezo, Rubén Herrán-Monge, Jesús Blanco, Pedro Enríquez, Isidoro Martínez, María Martín-Vicente, María José Muñoz-Gómez, Vicente Más, Mónica Vázquez, Olga Cano, Amalia Martínez de la Gándara, Covadonga Rodríguez, Gloria Andrade, Gloria Renedo, Juan Bustamante-Munguira, Ramón Cicuendez Ávila, María Salgado-Villén, Enrique Berruguilla-Pérez, Estel Güell, Fernando Javier Casadiego Monachello, María Recuerda Núñez, Juan Manuel Sánchez Calvo, Yhivian Peñasco-Martín, María Teresa García Unzueta, Adrián Ceccato, Laia Fernández-Barat, María Teresa Bouza Vieiro, Ana Moreno-Romero, Leire Pérez Bastida, Lorena del Río-Carbajo, Noelia Albalá Martínez, José Manuel Gómez, María Luisa Blasco, Jesús Caballero, Carme Barberà, Jessica González, María Teresa Nieto, Jorge Nieto-del Olmo, Estefanía Prol-Silva, Joan Canseco-Ribas, Jose María Eiros, Instituto de Salud Carlos III, Canadian Institutes of Health Research, Li Ka Shing Foundation, European Society of Clinical Microbiology and Infectious Diseases, Centro de Investigación Biomédica en Red - CIBERES (Enfermedades Respiratorias), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), and Unión Europea. Fondo Social Europeo (ESF/FSE)

Subjects
Microbiology (medical), Infectious Diseases, Spain, Virology, COVID-19, Microbiology
Abstract

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero (2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16-0·55; p

Published
2023

8. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author

González, Jessica, primary, de Batlle, Jordi, additional, Benítez, Iván D., additional, Torres, Gerard, additional, Santisteve, Sally, additional, Targa, Adriano D.S., additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Aguilà, Maria, additional, Seck, Fatty, additional, Ceccato, Adrián, additional, Ferrer, Ricard, additional, Motos, Anna, additional, Riera, Jordi, additional, Fernández, Laia, additional, Menéndez, Rosario, additional, Lorente, José Ángel, additional, Peñuelas, Oscar, additional, Garcia-Gasulla, Dario, additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Abril Palomares, Elena, additional, Aguilera, Luciano, additional, Rodríguez, Alejandro, additional, Boado Varela, Maria Victoria, additional, Beteré, Belén, additional, Pozo-Laderas, Juan Carlos, additional, Solé-Violan, Jordi, additional, Salvador-Adell, Inmaculada, additional, Novo, Mariana Andrea, additional, Barberán, José, additional, Amaya Villar, Rosario, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, Blandino Ortiz, Aaron, additional, Tamayo Lomas, Luis, additional, Úbeda, Alejandro, additional, Catalán-González, Mercedes, additional, Sánchez-Miralles, Angel, additional, Martínez Varela, Ignacio, additional, Jorge García, Ruth Noemí, additional, Franco, Nieves, additional, Gumucio-Sanguino, Víctor D., additional, Bustamante-Munguira, Elena, additional, Valdivia, Luis Jorge, additional, Caballero, Jesús, additional, Gallego, Elena, additional, Rodríguez, Covadonga, additional, Castellanos-Ortega, Álvaro, additional, Trenado, Josep, additional, Marin-Corral, Judith, additional, Albaiceta, Guillermo M., additional, de la Torre, Maria del Carmen, additional, Loza-Vázquez, Ana, additional, Vidal, Pablo, additional, Añón, Jose M., additional, Carbajales Pérez, Cristina, additional, Sagredo, Victor, additional, Carbonell, Nieves, additional, Socias, Lorenzo, additional, Barberà, Carme, additional, Estella, Angel, additional, Diaz, Emili, additional, de Gonzalo-Calvo, David, additional, Torres, Antoni, additional, Barbé, Ferran, additional, Cabello, María Aguilar, additional, Alcaraz-Serrano, Victoria, additional, Aldecoa, Cesar, additional, Alegre, Cynthia, additional, Calderón, Ángela Algaba, additional, Álvarez, Sergio, additional, Ruiz, Antonio Álvarez, additional, Andrea, Ruth, additional, Aparicio, Maria de Alba, additional, Arrieta, Marta, additional, Ayestarán, J. Ignacio, additional, Badia, Joan Ramon, additional, Badía, Mariona, additional, Pravia, Orville Báez, additional, Mariño, Ana Balan, additional, Balsera, Begoña, additional, Barbena, Laura, additional, Barbeta, Enric, additional, Bardi, Tommaso, additional, Segade, Patricia Barral, additional, Barroso, Marta, additional, García, José Ángel Berezo, additional, Bermejo, Jesus, additional, Bigas, Judit, additional, Blancas, Rafael, additional, Cortés, María Luisa Blasco, additional, Saera, María Bodi, additional, Bofill, Neus, additional, Vieiro, María Teresa Bouza, additional, Bueno, Leticia, additional, Bustamante-Munguira, Juan, additional, Martínez, Cecilia del Busto, additional, Hermoso, David Campi, additional, Fernández, Sandra Campos, additional, Cano, Iosune, additional, Canseco, Joan, additional, Fernández, Pablo Cardinal, additional, García, Laura Carrión, additional, Carvalho, Sulamita, additional, Castellà, Manuel, additional, Castellví, Andrea, additional, Castro, Pedro, additional, Centelles-Serrano, María José, additional, Ávila, Ramon Cicuendez, additional, Cillóniz, Catia, additional, Clar, Luisa, additional, Climent, Cristina, additional, Codina, Jordi, additional, Conde, Pamela, additional, Contreras, Sofía, additional, Parra, Raul de Frutos, additional, Sánchez, Raul de Pablo, additional, Mendoza, Diego De, additional, Díaz, Yolanda, additional, Vilas, María Digna Rivas, additional, Moreno, Cristina Dólera, additional, Dot, Irene, additional, Giraudo, Pedro Enríquez, additional, Arijón, Inés Esmorís, additional, Monjo, Teresa Farre, additional, Fernández, Javier, additional, Ferrando, Carlos, additional, Figueras, Albert, additional, Espina, Lorena Forcelledo, additional, Franquesa, Enric, additional, Furro, Àngels, additional, Gabarrus, Albert, additional, Galbán, Cristóbal, additional, García, Felipe, additional, García, Beatriz, additional, Prieto, Emilio García, additional, Redruello, Carlos García, additional, Sagastume, Amaia García, additional, Castillo, Maria Luisa Gascón, additional, Gomà, Gemma, additional, Casal, Vanesa Gómez, additional, Gómez, Silvia, additional, Gonzalez, Carmen Gómez, additional, Gordo, Federico, additional, Gracia, Maria Pilar, additional, Fernández, María José Gutierrez, additional, Herraiz, Alba, additional, Herrán-Monge, Rubén, additional, Ibarz, Mercedes, additional, Iglesias, Silvia, additional, Janer, Maria Teresa, additional, Jiménez, Gabriel, additional, Díaz, Mar Juan, additional, Kiarostami, Karsa, additional, Álvarez, Juan I. Lazo, additional, León, Miguel, additional, López-Gavín, Alexandre, additional, Guerrero, Desiree Macias, additional, Herrera, Nuria Mamolar, additional, Mendiluce, Rafael Mañez, additional, Mantellini, Cecilia L., additional, Naya, Gregorio Marco, additional, Barcos, Iris Marco, additional, Marcos, Pilar, additional, Peis, Enrique Marmol, additional, Cuadrado, Marta Martín, additional, Delgado, María Cruz Martin, additional, Vicente, Paula Martín, additional, Martínez, María, additional, Fernández, Carmen Eulalia Martínez, additional, Juan, Maria Dolores Martínez, additional, Palacios, Basilisa Martínez, additional, Jimenez, Juan Fernando Masa, additional, Masclans, Joan Ramon, additional, Maseda, Emilio, additional, Fernández, Eva María Menor, additional, Banderas, Priscila Metora, additional, Minguez, Olga, additional, Miralbés, Mar, additional, Monclou, Josman, additional, Montejo-González, Juan Carlos, additional, Montserrat, Neus, additional, Aznar, María Mora, additional, Morales, Dulce, additional, Cano, Sara Guadalupe Moreno, additional, Rodríguez, David Mosquera, additional, Muñoz-Bermúdez, Rosana, additional, Nicolás, José María, additional, Bou, Ramon Nogue, additional, Salinas, Rafaela Nogueras, additional, Ocón, Marta, additional, Ortega, Ana, additional, Ossa, Sergio, additional, Pagliarani, Pablo, additional, Parrilla, Francisco, additional, Pedregosa-Díaz, José, additional, Bastida, Leire Pérez, additional, Pérez, Purificación, additional, Pérez-García, Felipe, additional, Planelles, Gloria Pérez, additional, Rubio, Eva Pérez, additional, Laguna, David Pestaña, additional, Prados, Javier, additional, Pujol, Andrés, additional, Coll, Núria Ramon, additional, Sanchez-Giron, Gloria Renedo, additional, Roche-Campo, Ferran, additional, Rodriguez, Laura, additional, Castro, Felipe Rodríguez de, additional, Rodríguez, Silvia, additional, Ruiz, Covadonga Rodríguez, additional, Rubio, Jorge, additional, López, Alberto Rubio, additional, Ruiz-García, Ángela Leonor, additional, Miralles, Miriam Ruiz, additional, Murúa, Pablo Ryan, additional, Paz, Eva Saborido, additional, Degracia, Ana Salazar, additional, Sanchez, Miguel, additional, Sánchez, Ana, additional, Chinesta, Susana Sancho, additional, Santacoloma, Bitor, additional, Sariñena, Maria Teresa, additional, Pensado, Marta Segura, additional, Serra, Lidia, additional, Serra-Fortuny, Mireia, additional, Lázaro, Ainhoa Serrano, additional, Servià, Lluís, additional, Soliva, Laura, additional, Speziale, Carla, additional, Tormos, Adrián, additional, Torres, Mateu, additional, Tranque-Liberal, Celia, additional, Trefler, Sandra, additional, Trujillano, Javier, additional, Vaca, Rafaela, additional, Val, Estela, additional, Ruiz, Luis Valdivia, additional, Vallverdú, Montserrat, additional, Martin-Montalvo, Maria Van der Hofstadt, additional, Adrio, Sabela Vara, additional, Vázquez, Nil, additional, Vengoechea, Javier, additional, Vilà-Vilardel, Clara, additional, Vilanova, Judit, additional, Warrington, Tatiana Villada, additional, Yang, Hua, additional, Yang, Minlan, additional, and Zapatero, Ana, additional

Published
2023
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9. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Catia Cillóniz, Anna Motos, Tatiana Castañeda, Albert Gabarrús, Ferran Barbé, Antoni Torres, Víctor D. Gumucio-Sanguino, Rafael Mañez, Jordi Solé-Violan, Felipe Rodríguez de Castro, Fernando Suarez-Sipmann, Ruth Noemí Jorge García, María Mora Aznar, Mateu Torres, María Martinez, Cynthia Alegre, Jordi Riera, Sofía Contreras, Juan Manuel Pericas, Ricard Ferrer, Jesús Caballero, Javier Trujillano, Montse Vallverdú, Miguel León, Mariona Badía, Begoña Balsera, Lluís Servià, Judit Vilanova, Silvia Rodríguez, Neus Montserrat, Silvia Iglesias, Javier Prados, Sula Carvalho, Mar Miralbés, Josman Monclou, Gabriel Jiménez, Jordi Codina, Estela Val, Pablo Pagliarani, Jorge Rubio, Dulce Morales, Andrés Pujol, Àngels Furro, Beatriz García, Gerard Torres, Javier Vengoechea, David de Gonzalo-Calvo, Jessica González, Silvia Gomez, José M. Gómez, Nieves Franco, José Barberán, Guillermo M Albaiceta, Lorena Forcelledo Espina, Emilio García Prieto, Paula Martín Vicente, Cecilia del Busto Martínez, Pablo Vidal-Cortés, José Luis García Garmendia, María Aguilar Cabello, Carmen Eulalia Martínez Fernández, Nieves Carbonell, María Luisa Blasco Cortés, Ainhoa Serrano Lázaro, Mar Juan Díaz, Aaron Blandino Ortiz, Rosario Menendez, Luis Jorge Valdivia, María Victoria Boado, Susana Sancho Chinesta, Maria del Carmen de la Torre, Ignacio Martínez Varela, María Teresa Bouza Vieiro, Inés Esmorís Arijón, David Campi Hermoso, Rafaela Nogueras Salinas, Teresa Farre Monjo, Ramon Nogue Bou, Gregorio Marco Naya, Carme Barberà, Núria Ramon Coll, Mercedes Catalán-González, Juan Carlos Montejo-González, Gloria Renedo Sanchez-Giron, Juan Bustamante-Munguira, Elena Bustamante-Munguira, Ramon Cicuendez Avila, Nuria Mamolar Herrera, Raquel Almansa, Alicia Ortega, Jesús Bermejo-Martin, Víctor Sagredo, Jose Añon, Alexander Agrifoglio, Lucia Cachafeiro, Emilio Maseda, Lorenzo Socias, Mariana Andrea Novo, Albert Figueras, Maria Teresa Janer, Laura Soliva, Marta Ocón, Luisa Clar, J Ignacio Ayestarán, Yhivian Peñasco, Sandra Campos Fernández, Mireia Serra-Fortuny, Eva Forcadell-Ferreres, Immaculada Salvador-Adell, Neus Bofill, Berta Adell-Serrano, Josep Pedregosa Díaz, Núria Casacuberta-Barberà, Luis Urrelo-Cerrón, Àngels Piñol-Tena, Ferran Roche-Campo, Amalia Martínez de la Gándara, Pablo Ryan Murúa, Covadonga Rodríguez Ruíz, Laura Carrión García, Juan I Lazo Álvarez, José Ángel Lorente, Ana Loza-Vázquez, Desire Macias Guerrero, Arturo Huerta, Daniel Tognetti, Carlos García Redruello, David Mosquera Rodríguez, Eva María Menor Fernández, Sabela Vara Adrio, Vanesa Gómez Casal, Marta Segura Pensado, María Digna Rivas Vilas, Amaia García Sagastume, Raul de Pablo Sánchez, David Pestaña Laguna, Tommaso Bardi, Rosario Amaya Villar, Carmen Gómez Gonzalez, Maria Luisa Gascón Castillo, José Garnacho-Montero, María Luisa Cantón-Bulnes, Judith Marin-Corral, Cristina Carbajales Pérez, Joan Ramon Masclans, Ana Salazar Degracia, Judit Bigas, Rosana Muñoz-Bermúdez, Clara Vilà-Vilardel, Francisco Parrilla, Irene Dot, Ana Zapatero, Yolanda Díaz, María Pilar Gracia, Purificación Pérez, Andrea Castellví, Cristina Climent, Lidia Serra, Laura Barbena, Iosune Cano, Pilar Ricart, Alba Herraiz, Pilar Marcos, Laura Rodríguez, Maria Teresa Sariñena, Ana Sánchez, Alejandro Úbeda, María Cruz Martin Delgado, Elena Gallego, Juan Fernando Masa Jimenez, Gemma Gomà, Emi Díaz, Mercedes Ibarz, Diego De Mendoza, Enric Barbeta, Victoria Alcaraz-Serrano, Joan Ramon Badia, Manuel Castella, Leticia Bueno, Adrian Ceccato, Andrea Palomeque, Laia Fernandez Barat, Pamela Conde, Javier Fernández, Albert Gabarrus, Karsa Kiarostami, Alexandre López-Gavín, Cecilia L Mantellini, Carla Speziale, Nil Vázquez, Hua Yang, Minlan Yang, Carlos Ferrando, Pedro Castro, Marta Arrieta, Jose Maria Nicolas, Rut Andrea, Marta Barroso, Raquel Pérez, Sergio Álvarez, Dario Garcia-Gasulla, Adrián Tormos, Luis Tamayo Lomas, Cesar Aldecoa, Rubén Herrán-Monge, José Ángel Berezo García, Pedro Enríquez Giraudo, Pablo Cardinal Fernández, Alberto Rubio López, Orville Báez Pravia, Juan López Messa, Leire Pérez Bastida, Antonjo Alvarez Ruiz, José Trenado, Anna Parera Pous, Cristóbal Galbán, Ana López Lago, Eva Saborido Paz, Patricia Barral Segade, Ana Balan Mariño, Manuel Valledor Mendez, Raúl de Frutos, Luciano Aguilera, Felipe Pérez-García, Esther López-Ramos, Ángela Leonor Ruiz-García, Belén Beteré, Rafael Blancas, Cristina Dólera, Gloria Perez Planelles, Enrique Marmol Peis, Maria Dolores Martinez Juan, Miriam Ruiz Miralles, Eva Perez Rubio, Maria Van der Hofstadt Martin-Montalvo, Ángel Sánchez-Miralles, Tatiana Villada Warrington, Juan Carlos Pozo-Laderas, Angel Estrella, Sara Guadalupe Moreno Cano, Federico Gordo, Basilisa Martinez Palacios, Maite Nieto, Maria Teresa Nieto, Sergio Ossa, Ana Ortega, Miguel Sanchez, and Bitor Santacoloma

Subjects
Microbiology (medical), Infectious Diseases
Published
2022

10. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Gumucio-Sanguino, Víctor D., Mañez, Rafael, Solé-Violan, Jordi, de Castro, Felipe Rodríguez, Suarez-Sipmann, Fernando, García, Ruth Noemí Jorge, Aznar, María Mora, Torres, Mateu, Martinez, María, Alegre, Cynthia, Riera, Jordi, Contreras, Sofía, Pericas, Juan Manuel, Ferrer, Ricard, Caballero, Jesús, Trujillano, Javier, Vallverdú, Montse, León, Miguel, Badía, Mariona, Balsera, Begoña, Servià, Lluís, Vilanova, Judit, Rodríguez, Silvia, Montserrat, Neus, Iglesias, Silvia, Prados, Javier, Carvalho, Sula, Miralbés, Mar, Monclou, Josman, Jiménez, Gabriel, Codina, Jordi, Val, Estela, Pagliarani, Pablo, Rubio, Jorge, Morales, Dulce, Pujol, Andrés, Furro, Àngels, García, Beatriz, Torres, Gerard, Vengoechea, Javier, Gonzalo-Calvo, David de, González, Jessica, Gomez, Silvia, Gómez, José M., Franco, Nieves, Barberán, José, Albaiceta, Guillermo M, Espina, Lorena Forcelledo, Prieto, Emilio García, Vicente, Paula Martín, del Busto Martínez, Cecilia, Vidal-Cortés, Pablo, Garmendia, José Luis García, Cabello, María Aguilar, Fernández, Carmen Eulalia Martínez, Carbonell, Nieves, Cortés, María Luisa Blasco, Lázaro, Ainhoa Serrano, Díaz, Mar Juan, Ortiz, Aaron Blandino, Menendez, Rosario, Valdivia, Luis Jorge, Boado, María Victoria, Chinesta, Susana Sancho, del Carmen de la Torre, Maria, Varela, Ignacio Martínez, Vieiro, María Teresa Bouza, Arijón, Inés Esmorís, Hermoso, David Campi, Salinas, Rafaela Nogueras, Monjo, Teresa Farre, Bou, Ramon Nogue, Naya, Gregorio Marco, Barberà, Carme, Coll, Núria Ramon, Catalán-González, Mercedes, Montejo-González, Juan Carlos, Sanchez-Giron, Gloria Renedo, Bustamante-Munguira, Juan, Bustamante-Munguira, Elena, Avila, Ramon Cicuendez, Herrera, Nuria Mamolar, Almansa, Raquel, Ortega, Alicia, Bermejo-Martin, Jesús, Sagredo, Víctor, Añon, Jose, Agrifoglio, Alexander, Cachafeiro, Lucia, Maseda, Emilio, Socias, Lorenzo, Novo, Mariana Andrea, Figueras, Albert, Janer, Maria Teresa, Soliva, Laura, Ocón, Marta, Clar, Luisa, Ayestarán, J Ignacio, Peñasco, Yhivian, Fernández, Sandra Campos, Serra-Fortuny, Mireia, Forcadell-Ferreres, Eva, Salvador-Adell, Immaculada, Bofill, Neus, Adell-Serrano, Berta, Díaz, Josep Pedregosa, Casacuberta-Barberà, Núria, Urrelo-Cerrón, Luis, Piñol-Tena, Àngels, Roche-Campo, Ferran, de la Gándara, Amalia Martínez, Murúa, Pablo Ryan, Ruíz, Covadonga Rodríguez, García, Laura Carrión, Álvarez, Juan I Lazo, Lorente, José Ángel, Loza-Vázquez, Ana, Guerrero, Desire Macias, Huerta, Arturo, Tognetti, Daniel, Redruello, Carlos García, Rodríguez, David Mosquera, Fernández, Eva María Menor, Adrio, Sabela Vara, Casal, Vanesa Gómez, Pensado, Marta Segura, Vilas, María Digna Rivas, Sagastume, Amaia García, de Pablo Sánchez, Raul, Laguna, David Pestaña, Bardi, Tommaso, Villar, Rosario Amaya, Gonzalez, Carmen Gómez, Castillo, Maria Luisa Gascón, Garnacho-Montero, José, Cantón-Bulnes, María Luisa, Marin-Corral, Judith, Pérez, Cristina Carbajales, Masclans, Joan Ramon, Degracia, Ana Salazar, Bigas, Judit, Muñoz-Bermúdez, Rosana, Vilà-Vilardel, Clara, Parrilla, Francisco, Dot, Irene, Zapatero, Ana, Díaz, Yolanda, Gracia, María Pilar, Pérez, Purificación, Castellví, Andrea, Climent, Cristina, Serra, Lidia, Barbena, Laura, Cano, Iosune, Ricart, Pilar, Herraiz, Alba, Marcos, Pilar, Rodríguez, Laura, Sariñena, Maria Teresa, Sánchez, Ana, Úbeda, Alejandro, Delgado, María Cruz Martin, Gallego, Elena, Jimenez, Juan Fernando Masa, Gomà, Gemma, Díaz, Emi, Ibarz, Mercedes, De Mendoza, Diego, Barbeta, Enric, Alcaraz-Serrano, Victoria, Badia, Joan Ramon, Castella, Manuel, Bueno, Leticia, Ceccato, Adrian, Palomeque, Andrea, Barat, Laia Fernandez, Cillóniz, Catia, Conde, Pamela, Fernández, Javier, Gabarrus, Albert, Kiarostami, Karsa, López-Gavín, Alexandre, Mantellini, Cecilia L, Speziale, Carla, Vázquez, Nil, Yang, Hua, Yang, Minlan, Ferrando, Carlos, Castro, Pedro, Arrieta, Marta, Nicolas, Jose Maria, Andrea, Rut, Barroso, Marta, Pérez, Raquel, Álvarez, Sergio, Garcia-Gasulla, Dario, Tormos, Adrián, Lomas, Luis Tamayo, Aldecoa, Cesar, Herrán-Monge, Rubén, García, José Ángel Berezo, Giraudo, Pedro Enríquez, Fernández, Pablo Cardinal, López, Alberto Rubio, Pravia, Orville Báez, Messa, Juan López, Bastida, Leire Pérez, Ruiz, Antonjo Alvarez, Trenado, José, Pous, Anna Parera, Galbán, Cristóbal, Lago, Ana López, Paz, Eva Saborido, Segade, Patricia Barral, Mariño, Ana Balan, Mendez, Manuel Valledor, de Frutos, Raúl, Aguilera, Luciano, Pérez-García, Felipe, López-Ramos, Esther, Ruiz-García, Ángela Leonor, Beteré, Belén, Blancas, Rafael, Dólera, Cristina, Planelles, Gloria Perez, Peis, Enrique Marmol, Juan, Maria Dolores Martinez, Miralles, Miriam Ruiz, Rubio, Eva Perez, Martin-Montalvo, Maria Van der Hofstadt, Sánchez-Miralles, Ángel, Warrington, Tatiana Villada, Pozo-Laderas, Juan Carlos, Estrella, Angel, Cano, Sara Guadalupe Moreno, Gordo, Federico, Palacios, Basilisa Martinez, Nieto, Maite, Nieto, Maria Teresa, Ossa, Sergio, Ortega, Ana, Sanchez, Miguel, Santacoloma, Bitor, Motos, Anna, Castañeda, Tatiana, Gabarrús, Albert, Barbé, Ferran, and Torres, Antoni

Published
2023
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11. Low anti‐SARS‐CoV‐2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID‐19 patients

Author

Rubén Herrán-Monge, Wysali Trapiello, Laia Fernández-Barat, Cristina Doncel, Milagros González-Rivera, Carolina Puertas, Marta Domínguez-Gil, Jesus F. Bermejo-Martin, María José Muñoz-Gómez, Elena Bustamante, Felipe Pérez-García, Ana P. Tedim, Pedro Enriquez, Isidoro Martínez, Jesús Rico-Feijoo, David J. Kelvin, Vicente Mas, María Martín-Vicente, Noelia Jorge, P. Olivares, José María Eiros, Raquel Almansa, Mónica Herrero Vázquez, Antoni Torres, Ferran Barbé, Cesar Aldecoa, Anna Motos, José Manuel Gómez, Gloria Renedo, Jose Ángel Berezo, Amanda de la Fuente, Salvador Resino, Alicia Ortega, Nuria Mamolar, Ramón Cicuendez, Juan Bustamante-Munguira, Jamil Antonio Cedeno, Silvia Martín, Luis Tamayo, and Ricard Ferrer

Subjects
Coronavirus disease 2019 (COVID-19), Critical Illness, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Antibodies, Viral, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, S Antibody, antigenaemia, Internal Medicine, Humans, antibodies, Medicine, 030212 general & internal medicine, Antigens, Viral, 030304 developmental biology, 0303 health sciences, Viral Components, biology, SARS-CoV-2, Critically ill, business.industry, Brief Report, COVID-19, mortality, 3. Good health, Icu admission, Viral replication, Immunology, biology.protein, RNA, Viral, RNA, Brief Reports, Antibody, business
Abstract

Background Anti‐SARS‐CoV‐2 S antibodies prevent viral replication. Critically ill COVID‐19 patients show viral material in plasma, associated with a dysregulated host response. If these antibodies influence survival and viral dissemination in ICU‐COVID patients is unknown. Patients/Methods We studied the impact of anti‐SARS‐CoV‐2 S antibodies levels on survival, viral RNA‐load in plasma, and N‐antigenaemia in 92 COVID‐19 patients over ICU admission. Results Frequency of N‐antigenaemia was >2.5‐fold higher in absence of antibodies. Antibodies correlated inversely with viral RNA‐load in plasma, representing a protective factor against mortality (Adjusted HR [CI 95%], p): (S IgM [AUC ≥ 60]: 0.44 [0.22; 0.88], 0.020); (S IgG [AUC ≥ 237]: 0.31 [0.16; 0.61]

Published
2021

13. Risk factors for mortality in patients with COVID-19 needing extracorporeal respiratory support

Author

Patricia Santa Teresa, Eduard Argudo, Elena Sandoval, Camilo Bonilla, Luis Chiscano, Ricardo Gimeno, Maria Santos Martinez-Martinez, Gloria Renedo, Héctor Villanueva-Fernández, Manuel Alfonso García, María Paz Fuset, Maria Victoria Boado, Pablo Coto Millán, Roberto Roncon-Albuquerque, Jorge Duerto, Pablo Ruiz de Gopegui, Sergi Martinez, Phillip Fortuna, Stephani María Luna, Vanesa Gómez, Daniel Vidal Pérez, Joaquín Colomina, Jordi Riera, Pablo Blanco-Schweizer, Pedro Eduardo Silva, Pilar Ricart, Alfredo González-Pérez, Helena Pérez-Chomón, Roberto Voces, Aaron Blandino Ortiz, Jose E. Naranjo, Emilio Rodríguez-Ruiz, Marta Garcia, Ana Paula Vaz, J. Veganzones, Sara Alcántara, and Carlos Albacete

Subjects
Pulmonary and Respiratory Medicine, ARDS, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, MEDLINE, Disease, Extracorporeal, Extracorporeal Membrane Oxygenation, Risk Factors, Pandemic, medicine, Extracorporeal membrane oxygenation, Research Letter, Humans, In patient, Pandemics, Retrospective Studies, Respiratory Distress Syndrome, business.industry, SARS-CoV-2, MEMBRANE-OXYGENATION, COVID-19, medicine.disease, DISTRESS-SYNDROME, Emergency medicine, business, Respiratory Insufficiency
Abstract

Series describing the evolution of patients with severe acute respiratory distress syndrome (ARDS) secondary to COVID-19 and supported with extracorporeal membrane oxygenation (ECMO) during the first wave of the pandemic have reported mortalities ranging from 30 to 60% [1, 2]. More recent publications have demonstrated a trend towards a higher mortality in COVID-19 patients receiving support in later periods of the pandemic, even though the overall mortality of the disease seems lower [3, 4]. The reasons for this difference are not clear. Statistical analysis was carried out in the Statistics and Bioinformatics Unit (UEB) Vall d'Hebron Hospital Research Institute (VHIR). The following practitioners provided care for the study patients

Published
2022

14. Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality?

Author

Lluís Servia-Goixart, Juan C. Lopez-Delgado, Teodoro Grau-Carmona, Javier Trujillano-Cabello, M Luisa Bordeje-Laguna, Esther Mor-Marco, Esther Portugal-Rodriguez, Carol Lorencio-Cardenas, Juan C. Montejo-Gonzalez, Paula Vera-Artazcoz, Laura Macaya-Redin, Juan Francisco Martinez-Carmona, Rayden Iglesias-Rodriguez, Diana Monge-Donaire, José L. Flordelis-Lasierra, Beatriz Llorente-Ruiz, Eva M. Menor-Fernández, Itziar Martínez de Lagrán, Juan C. Yebenes-Reyes, Joan Escobar-Ortiz, Neus Montserrat-Ortiz, Amalia Zapata-Rojas, Iris Bautista-Redondo, Ana Cruz-Ramos, Laura Diaz-Castellanos, Miriam Morales-Cifuentes, Montserrat Plaza- Bono, Juan Carlos Montejo-Gonzalez, Susana Temprano-Vazquez, Veronica Arjona-Diaz, Carlos Garcia-Fuentes, Carolina Mudarra-Reche, Maria Orejana-Martin, Juan Carlos Lopez-Delgado, Africa Lores-Obradors, Laura Anguela-Calvet, Gloria Muñoz-Del Río, Pamela Alejandra Revelo-Esquibel, Henry Alanez-Saavedra, Pau Serra-Paya, Stephani Maria Luna-Solis, Alvaro Salinas-Canovas, Fernando De Frutos-Seminario, Oriol Rodriguez-Queralto, Carlos Gonzalez-Iglesias, Monica Zamora-Elson, Eugenia de la Fuente-O'Connor, Carlos Seron- Arbeloa, Nestor Bueno-Vidales, Ana Martin-Luengo, Angel Sanchez-Miralles, Enrique Marmol-Peis, Miriam Ruiz-Miralles, Maria Gonzalez-Sanz, Arantzazu Server-Martinez, Belen Vila-Garcia, Raquel Flecha-Viguera, Sara Aldunate-Calvo, Jose Luis Flordelis-Lasierra, Irene Jimenez-del Rio, Jose Ramon Mampaso-Recio, Jose Manuel Rodriguez-Roldan, Rosa Gastaldo-Simeon, Josefina Gimenez-Castellanos, Juan Francisco Fernandez-Ortega, Juan F. Martinez-Carmona, Esther Lopez-Luque, Ane Ortega-Ordiales, Monica Crespo-Gomez, Victor Ramirez-Montero, Esther Lopez-García, Arturo Navarro-Lacalle, Pilar Martinez-Garcia, Maria Inmaculada Dominguez-Fernandez, Marta Izura-Gomez, Susana Hernandez-Duran, Ma Luisa Bordeje-Laguna, Yaiza Rovira-Valles, Viridiana Philibert, Maravillas de las Nieves Alcazar-Espin, Aurea Higon-Cañigral, Enrique Calvo-Herranz, Diego Manzano-Moratinos, David Andaluz-Ojeda, Laura Parra-Morais, Rafael Citores-Gonzalez, Maria Teresa Garcia-Gonzalez, Gloria Renedo Sanchez-Giron, Elisabeth Navas-Moya, Carles Ferrer-Pereto, Cristina Lluch-Candal, Jessica Ruiz-Izquierdo, Silvia Castor-Bekari, Cristina Leon-Cinto, Itziar Martinez de Lagran, Juan Carlos Yebenes-Reyes, Beatriz Nieto-Martino, Clara Vaquerizo-Alonso, Susana Almanza-Lopez, Sonia Perez-Quesada, Jose Luis Anton-Pascual, Judith Marin-Corral, Maite Sistachs-Baquedano, Maria Hacer-Puig, Marina Picornell-Noguera, Lidon Mateu-Campos, Clara Martinez-Valero, Andrea Ortiz-Suñer, María Cristina Martinez-Diaz, Maria Trascasa- Muñoz De La Peña, Diego Anibal Rodriguez-Serrano, Leticia Fernandez-Salvatierra, Mireia Barcelo-Castello, Paula Millan-Taratiel, Antonio Tejada-Artigas, Ines Martinez-Arroyo, Pilar Araujo-Aguilar, Maria Fuster-Cabre, Laura Andres-Gines, Sonia Soldado-Olmo, Eva Mª Menor-Fernandez, Lucas Lage-Cendon, Alberto Touceda-Bravo, Laura Sanchez-Ales, Laura Almorin-Gonzalvez, Maria Gero-Escapa, Esther Martinez-Barrio, Sergio Ossa-Echeverri, [Servia-Goixart L, Trujillano-Cabello J] Hospital Universitari Arnau de Vilanova, Intensive Care Department, Lleida, Spain. IRBLLeida (Institut de Recerca Biomedica de Lleida Fundacio Dr. Pifarré, Lleida Biomedical Research Institute's Dr. Pifarré Foundation, Lleida, Spain. [Lopez-Delgado JC] Hospital Universitari de Bellvitge, Intensive Care Department, Hospitalet de Llobregat, Spain. IDIBELL (Institut d’Investigacio Biomédica Bellvitge, Biomedical Investigation Institute of Bellvitge, Hospitalet de Llobregat, Spain. [Grau-Carmona T] Hospital Universitario 12 de Octubre, Intensive Care Department, Madrid, Spain. i+12 (Instituto de Investigacion Sanitaria Hospital 12 de Octubre, Research Institute Hospital 12 de Octubre), Madrid, Spain. [Bordeje-Laguna ML, Mor-Marco E] Hospital Universitario Germans Trias i Pujol, Intensive Care Department, Badalona, Spain. [Iglesias-Rodriguez R] Hospital General de Granollers, Intensive Care Department, Granollers, Spain, and Hospital General de Granollers

Subjects
Adult, Parenteral Nutrition, Pediatrics, medicine.medical_specialty, Multivariate analysis, Critical Care, Endocrinology, Diabetes and Metabolism, Nutritional Status, Enteral administration, Nutritional therapy, Enteral Nutrition, Medicina intensiva, Epidemiology and Biostatistics::Biostatistics::Information Storage and Retrieval::Mortality Registries [PUBLIC HEALTH], Intensive care, Mortalitat, Medicine, Humans, Nutrició enteral, Critical care medicine, Intensive care unit, Medical nutrition therapy, Mortality, Nutrició, vigilancia sanitaria de los servicios de salud::centros sanitarios::hospitales::unidades hospitalarias::unidades de cuidados intensivos [VIGILANCIA SANITARIA], Nutrition, Therapeutics::Feeding Methods::Enteral Nutrition [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Nutrition and Dietetics, epidemiología y bioestadística::bioestadística::almacenamiento y recuperación de la información::registros de mortalidad [SALUD PÚBLICA], business.industry, Hazard ratio, Parenteral nutrition, Confidence interval, Intensive Care Units, terapéutica::métodos de alimentación::nutrición enteral [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Observational study, Health Surveillance of Health Services::Health Facilities::Hospitals::Hospital Units::Intensive Care Units [HEALTH SURVEILLANCE], business, Enteral nutrition
Abstract

Background: The importance of artificial nutritional therapy is underrecognized, typically being considered an adjunctive rather than a primary therapy. We aimed to evaluate the influence of nutritional therapy on mortality in critically ill patients.Methods: This multicenter prospective observational study included adult patients needing artificial nutritional therapy for >48 h if they stayed in one of 38 participating intensive care units for ≥72 h between April and July 2018. Demographic data, comorbidities, diagnoses, nutritional status and therapy (type and details for ≤14 days), and outcomes were registered in a database. Confounders such as disease severity, patient type (e.g., medical, surgical or trauma), and type and duration of nutritional therapy were also included in a multivariate analysis, and hazard ratios (HRs) and 95% confidence intervals (95%CIs) were reported.Results: We included 639 patients among whom 448(70.1%) and 191(29.9%) received enteral and parenteral nutrition, respectively. Mortality was 25.6%, with non-survivors having the following characteristics: older age; more comorbidities; higher Sequential Organ Failure Assessment (SOFA) scores (6.6±3.3 vs 8.4±3.7; P); greater nutritional risk (Nutrition Risk in the Critically Ill [NUTRIC] score: 3.8±2.1 vs 5.2±1.7; P); more vasopressor requirements (70.4% vs 83.5%; P=0.001); and more renal replacement therapy (12.2% vs 23.2%; P=0.001). Multivariate analysis showed that older age (HR: 1.023; 95% CI: 1.008–1.038; P=0.003), higher SOFA score (HR: 1.096; 95% CI: 1.036–1.160; P=0.001), higher NUTRIC score (HR: 1.136; 95% CI: 1.025–1.259; P=0.015), requiring parenteral nutrition after starting enteral nutrition (HR: 2.368; 95% CI: 1.168–4.798; P=0.017), and a higher mean Kcal/Kg/day intake (HR: 1.057; 95% CI: 1.015–1.101; P=0.008) were associated with mortality. By contrast, a higher mean protein intake protected against mortality (HR: 0.507; 95% CI: 0.263–0.977; P=0.042).Conclusions: Old age, higher organ failure scores, and greater nutritional risk appear to be associated with higher mortality. Patients who need parenteral nutrition after starting enteral nutrition may represent a high-risk subgroup for mortality due to illness severity and problems receiving appropriate nutritional therapy. Mean calorie and protein delivery also appeared to influence outcomes.Trial Registration: ClinicaTrials.gov NCT: 03634943.

Published
2022

15. Absent or insufficient anti-SARS-CoV-2 S antibodies at ICU admission are associated to higher viral loads in plasma, antigenemia and mortality in COVID-19 patients

Author

Raquel Almansa, Felipe Pérez-García, P. Olivares, José María Eiros, Ruben Herran, Jamil Antonio Cedeno, Anna Motos, Antoni Torres, Ferran Barbé, Salvador Resino, Marta Domínguez-Gil, Alicia Ortega, Gloria Renedo, Mónica Herrero Vázquez, Milagros González-Rivera, Amanda de la Fuente, María José Muñoz-Gómez, Elena Bustamante, Ricard Ferrer, Laia Fernández-Barat, María Martín-Vicente, Nuria Mamolar, Carolina Puertas, Jesus F. Bermejo-Martin, Jose Ángel Berezo, Cesar Aldecoa, Juan Bustamante-Munguira, Ana P. Tedim, Isidoro Martínez, Noelia Jorge, Jesús Rico-Feijoo, David J. Kelvin, Pedro Enriquez, Luis Tamayo, Vicente Mas, Ramón Cicuendez, José Manuel Gómez, and Silvia Martín

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), biology, business.industry, Proportional hazards model, Gastroenterology, Icu admission, Polyclonal antibodies, Internal medicine, Monoclonal, biology.protein, Risk of mortality, Medicine, Antibody, business, Viral load
Abstract

Purposeto evaluate the association between anti-SARS-CoV-2 S IgM and IgG antibodies with viral RNA load in plasma, the frequency of antigenemia and with the risk of mortality in critically ill patients with COVID-19.Methodsanti-SARS-CoV-2 S antibodies levels, viral RNA load and antigenemia were profiled in plasma of 92 adult patients in the first 24 hours following ICU admission. The impact of these variables on 30-day mortality was assessed by using Kaplan-Meier curves and multivariate Cox regression analysis.Resultsnon survivors showed more frequently absence of anti-SARS-CoV-2 S IgG and IgM antibodies than survivors (26.3% vs 5.6% for IgM and 18.4% vs 5.6% for IgG), and a higher frequency of antigenemia (47.4% vs 22.2%) (p p]: [S IgM (AUC ≥60): 0.48 (0.24; 0.97), 0.040]; [S IgG (AUC ≥237): 0.47 (0.23; 0.97), 0.042]; [Antigenemia (+): 2.45 (1.27; 4.71), 0.007]; [N1 viral load (≥ 2.156 copies/mL): 2.21 (1.11; 4.39),0.024]; [N2 viral load (≥ 3.035 copies/mL): 2.32 (1.16; 4.63), 0.017]. Frequency of antigenemia was >2.5-fold higher in patients with absence of antibodies. Levels of anti-SARS-CoV-2 S antibodies correlated inversely with viral RNA load.Conclusionabsence / insufficient levels of anti-SARS-CoV-2 S antibodies following ICU admission is associated to poor viral control, evidenced by increased viral RNA loads in plasma, higher frequency of antigenemia, and also to increased 30-day mortality.Take-home messageabsent or low levels of antibodies against the S protein of SARS-CoV- 2 at ICU admission is associated to an increased risk of mortality, higher frequency of antigenemia and higher viral RNA loads in plasma. Profiling anti-SARS-CoV-2 s antibodies at ICU admission could help to predict outcome and to better identify those patients potentially deserving replacement treatment with monoclonal or polyclonal antibodies.

Published
2021

16. Extracorporeal Respiratory Support During the First and Second Waves of the COVID-19 Pandemic in Spain and Portugal: An Observational, Multicenter, Cohort Study Including 334 Patients

Author

Jordi Riera, Ana Vaz, Pablo Blanco-Schweizer, Sara Alcántara, María Paz Fuset, Philip Fortuna, Carlos Albacete, Pablo Millán, Pilar Ricart, Aarón Blandino, María Victoria Boado, Pablo Ruiz de Gopegui, Patricia Santa Teresa, Jose Alfonso Rubio, Elena Sandoval, Helena Pérez-Chomón, Alfredo González-Pérez, Jorge Duerto, Ricardo Gimeno, Joaquín Colomina, Vanesa Gómez, Gloria Renedo, Jose Naranjo, Manuel Alfonso, Emilio Rodríguez-Ruíz, Camilo Bonilla, Marta García, Héctor Villanueva-Fernández, Stephani María Luna, Pedro Eduardo Silva, Daniel Perez, Javier Veganzones, Roberto Voces, Sergi Martínez, Roberto Roncon-Albuquerque Jr, and ECMOVIBER Study Group

Subjects
Mechanical ventilation, Pediatrics, medicine.medical_specialty, ARDS, business.industry, medicine.medical_treatment, Hazard ratio, Lower risk, medicine.disease, Extracorporeal, Cohort, Extracorporeal membrane oxygenation, medicine, business, Cohort study
Abstract

Background: The benefits of the use of extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) due to COVID-19 remain controversial. Methods: In this multicenter cohort study, we analyzed all the adult patients with ARDS due to COVID-19 who received extracorporeal respiratory support at 25 ECMO centers (23 in Spain and two in Portugal) during the first and second waves of the pandemic. Follow-up ended on December 1. Our primary aim was to describe this cohort taking into account its evolution during the pandemic. We also investigated hazard ratios for hospital mortality. Findings: A total of 334 patients were included. Patients supported during the second wave [176 (52.7%)] were older (54.6±9.7 vs 50.9±10.6,p=0.001), had more comorbidities, were more frequently coinfected at the start of ECMO [62 (35.2%) vs 37 (23.3%),p=0.028] and were less likely to be treated at a high-volume center [42 (23.9%) vs 54 (34.2%),p=0.008] than those supported during the first wave [158 (47.3%)]. At December 1, 134 (40.1%) patients had died and 49 (14.6%) were still on ECMO. Among patients supported during the first wave, 93 (58.8%) were discharged and all were alive at six months. Older age [HR 3.49 (1.94-6.28),p

Published
2021

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