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2 results on '"Gloria María Garnacho-Saucedo"'

1. Alemtuzumab in refractory Sézary syndrome

Author

Carmen María Alcántara Reifs, Rafael Salido-Vallejo, Gloria María Garnacho-Saucedo, Sofía De la Corte-Sánchez, Alberto González-Menchen, and Antonio Vélez García-Nieto

Subjects
Antibodies, monoclonal, humanized, Lymphoma, T-Cell, cutaneous, Sézary syndrome, Treatment outcome, Dermatology, RL1-803
Abstract

Abstract: Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by the triad of erythroderma, lymphadenopathy and circulating atypical cells. The emergence of new molecular targets has enabled the development of drugs such as alemtuzumab, an anti-CD52 monoclonal antibody, which has shown promising results in the treatment of this entity. We report the case of a 70-year-old male with refractory Sézary syndrome in whom treatment with alemtuzumab achieved an 80% skin lesion clearance with complete haematologic and radiologic response. The treatment was discontinued after 4 months due to adverse effects, with the patient showing a sustained response without disease progression after 13 months of follow-up.

Published
2016
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2. Therapeutic Hotline: Topical glycopyrrolate: a successful treatment for craniofacial hyperhidrosis and eccrine hidrocystomas

Author

Rafael Jiménez Puya, Gloria María Garnacho Saucedo, Alfonso Rodríguez Bujaldon, and José Carlos Moreno Jiménez

Subjects
medicine.medical_specialty, Eccrine hidrocystoma, Hidrocystoma, Physical examination, Muscarinic Antagonists, Dermatology, Eccrine Glands, Administration, Cutaneous, Eyelid Neoplasms, Asymptomatic, Benign tumor, medicine, Humans, Hyperhidrosis, Effective treatment, Glycopyrrolate, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Surgery, Sweat Gland Neoplasms, Treatment Outcome, Female, medicine.symptom, business, Craniofacial hyperhidrosis
Abstract

Eccrine hidrocystoma is a benign tumor derived from eccrine sudoriparous glands. Most eccrine hidrocystomas are solitary and asymptomatic lesions. Multiple hidrocystomas are unusual and have been associated with Graves' disease, Parkinson's disease, and idiopathic craniofacial hyperhidrosis. This report describes the successful treatment of multiple center facial eccrine hidrocystomas associated with craniofacial hyperhidrosis with 0.5% glycopyrrolate aqueous solution applied locally for 1 week. The present authors obtained a very significant improvement without leaving any trace of clinical examination. Multiple eccrine hidrocystomas are a rare condition and, to date, no effective treatment has been reported. Topical glycopyrrolate is a very good first-line treatment option.

Published
2010

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