1. Efficacy of a new immunonutrition formula with extra virgin olive oil in the reduction of complications in surgeries of upper digestive tract tumors
- Author
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Rocío Villar-Taibo, Alfonso Vidal-Casariego, Alicia Santamaría-Nieto, Ana Cantón-Blanco, Ana B. Crujeiras, Gloria Lugo Rodríguez, Gemma Rodríguez-Carnero, Francisco Pita Gutiérrez, Antía Fernández Pombo, Everardo Díaz-López, Andrea Román Eyo, Uxía Rodríguez Lavandeira, Alberto Pena-Dubra, and Miguel Ángel Martínez-Olmos
- Subjects
immunonutrition ,arginine ,omega-3 fatty acids ,extra virgin olive oil ,surgery ,cancer ,Nutrition. Foods and food supply ,TX341-641 - Abstract
BackgroundTo demonstrate whether a nutritional supplement enriched with arginine, nucleotides, omega-3 fatty acids, and extra virgin olive oil reduces postoperative complications in patients with tumors in the upper digestive tract.MethodsA randomized, controlled, double-blind, multicenter clinical trial, in which a new immunomodulatory formula with extra virgin olive oil was compared with a standard isoprotein and isoenergetic formula. Patients with gastric, esophageal or biliopancreatic tumors were recruited to receive two units of immunomodulatory formula or control, 5 days before the surgical intervention.ResultsA total of 119 patients were recruited. There was a significant reduction in the number of reinterventions (7.7 vs. 20.4%; p = 0.044) in the intervention group. There was a significant reduction in the development of fistulas in patients with phase angles >5.7°. Also, there were fewer readmissions after biliopancreatic surgeries (0.0 vs. 100%; p = 0.014). The length of hospital stay was similar between groups; however, with the immunomodulatory formula, the patients exhibited greater phase angle at the end of follow-up.ConclusionThe immunomodulatory formula with extra virgin olive oil administered 5 days before surgery for stomach, esophageal and biliopancreatic tumors improved cellular health and reduced postoperative complications.Clinical trial registration: [https://clinicaltrials.gov/], identifier [NCT04027088].
- Published
- 2024
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