94 results on '"Gloger S"'
Search Results
2. Urinary fistulae after robotic partial nephrectomy – analysis of a multicenter database
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Fuhrmann, C., primary, Katzendorn, O., additional, Schiefelbein, F., additional, Schoen, G., additional, Wiesinger, C., additional, Pfuner, J., additional, Ubrig, B., additional, Gloger, S., additional, Nuhn, P., additional, Eraky, A., additional, Wagner, C., additional, Ayanle, A., additional, Kesch, C., additional, Al-Nader, M., additional, Hadaschik, B.A., additional, Kuczyk, M.A., additional, Faraj Tabrizi, P., additional, Siemer, S., additional, Stöckle, M., additional, Zeuschner, P., additional, and Harke, N.N., additional
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- 2024
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3. Why do surgeons need to change their intraoperative plan? A multicentric analysis of conversions in 2459 robot-assisted partial nephrectomies
- Author
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Katzendorn, O., primary, Harke, N.N., additional, Schiefelbein, F., additional, Schoen, G., additional, Wiesinger, C., additional, Pfuner, J., additional, Ubrig, B., additional, Gloger, S., additional, Osmonov, D., additional, Eraky, A., additional, Wagner, C., additional, Ayanle, A., additional, Hadaschik, B.A., additional, Kesch, C., additional, Kuczyk, M.A., additional, Siemer, S., additional, Stöckle, M., additional, and Zeuschner, P., additional
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- 2023
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4. Perioperative und Langzeitergebnisse von minimal-invasiven Ureterrekonstruktionen
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Duda, N, Schoening, M, Gloger, S, Ubrig, B, Duda, N, Schoening, M, Gloger, S, and Ubrig, B
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- 2023
5. Change of plan – A multicentric analysis of conversions in robot-assisted partial nephrectomy
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Katzendorn, O., primary, Harke, N.N., additional, Schiefelbein, F., additional, Schoen, G., additional, Wiesinger, C., additional, Pfuner, J., additional, Ubrig, B., additional, Gloger, S., additional, Osmonov, D., additional, Eraky, A., additional, Witt, J.H., additional, Wagner, C., additional, Hadaschik, B.A., additional, Radtke, J.P., additional, Kuczyk, M.A., additional, Huusmann, S., additional, Siemer, S., additional, Stöckle, M., additional, and Zeuschner, P.., additional
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- 2022
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6. Aqua-Ablation der Prostata: Ergebnisse nach 167 Fällen
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Paulics, L, Gloger, S, Ubrig, B, Paulics, L, Gloger, S, and Ubrig, B
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- 2022
7. Erfassung der Lymphozelenhäufigkeit bei robotisch-assistierten minimal-invasiven radikalen Prostatektomien unter Bildung eines peritonealen Schwenklappens (ProLy) - Ergebnisse einer prospektiv randomisierten Multicenter-Studie
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Gloger, S, Ubrig, B, Boy, A, Leyh-Bannurah, SR, Siemer, S, Arndt, M, Stolzenburg, JU, Franz, T, Oelke, M, Witt, JH, Gloger, S, Ubrig, B, Boy, A, Leyh-Bannurah, SR, Siemer, S, Arndt, M, Stolzenburg, JU, Franz, T, Oelke, M, and Witt, JH
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- 2022
8. Impact of surgical experience prior to robot-assisted partial nephrectomy on surgical outcomes: Large multicenter analysis with 2,500 patients
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Zeuschner, P., primary, Siemer, S., additional, Stöckle, M., additional, Schiefelbein, F., additional, Schneller, A., additional, Schön, G., additional, Wiesinger, C., additional, Pfuner, J., additional, Ubrig, B., additional, Gloger, S., additional, Osmonov, D., additional, Eraky, A., additional, Witt, J., additional, Liakos, N., additional, Wagner, C., additional, Hadaschik, B., additional, Radtke, J.P., additional, Al Nader, M., additional, Imkamp, F., additional, Kuczyk, M., additional, Huusmann, S., additional, and Harke, N., additional
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- 2022
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- View/download PDF
9. Low Surface Recombination Velocity using amorphous Silicon on industrial-type cleaned Surfaces
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Gloger, S., Brinkmann, N., and Terheiden, B.
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- 2011
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10. PE065 - Why do surgeons need to change their intraoperative plan? A multicentric analysis of conversions in 2459 robot-assisted partial nephrectomies
- Author
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Katzendorn, O., Harke, N.N., Schiefelbein, F., Schoen, G., Wiesinger, C., Pfuner, J., Ubrig, B., Gloger, S., Osmonov, D., Eraky, A., Wagner, C., Ayanle, A., Hadaschik, B.A., Kesch, C., Kuczyk, M.A., Siemer, S., Stöckle, M., and Zeuschner, P.
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- 2023
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11. Oestradiol-Induced Synapse Formation in the Female Hippocampus: Roles of Oestrogen Receptor Subtypes
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Zhou, L., Fester, L., Haghshenas, S., de Vrese, X., von Hacht, R., Gloger, S., Brandt, N., Bader, M., Vollmer, G., and Rune, G. M.
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- 2014
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12. Die bronchogene Zyste: ein Fallbericht zur Darstellung als Differentialdiagnose der retroperitonealen Raumforderung und Nebennierenneoplasie
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Gloger, S
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Die bronchogene Zyste ist eine gutartige Raumforderung, die vorwiegend thorakal als embryonale Fehlbildung entsteht, jedoch in seltenen Fällen retroperitoneal vorkommt und hier vorwiegend differentialdiagnostisch zu neoplastischen Prozessen der Nebennieren berücksichtigt werden[zum vollständigen Text gelangen Sie über die oben angegebene URL], 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
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- 2020
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13. High prevalence of thyroid abnormalities in a Chilean psychiatric outpatient population
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Fardella, Carlos E., Gloger, S., Figueroa, R., Santis, R., Gajardo, C., Salgado, C., Barroilhet, S., and Foradori, A.
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- 2000
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14. PE42 - Change of plan – A multicentric analysis of conversions in robot-assisted partial nephrectomy
- Author
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Katzendorn, O., Harke, N.N., Schiefelbein, F., Schoen, G., Wiesinger, C., Pfuner, J., Ubrig, B., Gloger, S., Osmonov, D., Eraky, A., Witt, J.H., Wagner, C., Hadaschik, B.A., Radtke, J.P., Kuczyk, M.A., Huusmann, S., Siemer, S., Stöckle, M., and Zeuschner, P..
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- 2022
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15. Computer-assisted 3D reconstruction of the terminal branches of the cerebral arteries: III. Posterior cerebral artery and circle of Willis
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Gloger, S., Gloger, A., Vogt, H., and Kretschmann, H. J.
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- 1994
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16. Computer-assisted 3D reconstruction of the terminal branches of the cerebral arteries: II. Middle cerebral artery
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Gloger, S., Gloger, A., Vogt, H., and Kretschmann, H. -J.
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- 1994
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17. Computer-assisted 3D reconstruction of the terminal branches of the cerebral arteries: I. Anterior cerebral artery
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Gloger, S., Gloger, A., Vogt, H., and Kretschmann, H. -J.
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- 1994
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18. Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis
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Paul, O'Connor, Wolinsky, Jerry S., Christian, Confavreux, Giancarlo, Comi, Ludwig, Kappos, Olsson, Tomas P., Hadj, Benzerdjeb, Philippe, Truffinet, Lin, Wang, Aaron, Miller, Temso Trial Group Reingold, Freedman Ms S., Cutter, G., Antel, J., Barkhof, F., Maddrey, W., Ravnborg, M., Schenker, S., O'Connor, P., Wolinsky, J. S., Confavreux, C., Comi, G., Kappos, L., Olsson, T. P., Miller, A., Freedman, Mark S., Narayana, P. A., Nelson, F., Vainrub, I., Datta, S., He, R., Gates, B., Ton, K., Wamil, B., Truffinet, P., Igau, B., Nicolas, V., Notelet, L., Payrard, S., Wijnand, P., Devore, S., H. H., Li, Osho, T., Wang, L., Wei, L., Dukovic, D., Ling, Y., Benzerdjeb, H., Mednikova, Z., Trabelsi, N., Musset, M., Merrill, D., Turpault, S., Williams, B., Nortmeyer, H., Kirst, E., Witthaus, E., Chen, S., Maida, E., Auff, E., Fazekas, F., Berger, T., Bhan, V., Bouchard, J. P., Duquette, P., Freedman, M., Grand'Maison, F., Kremenchutzky, M., Bourque, C., Marrie, R. A., Melanson, M., Patry, D., Oger, J., Stefanelli, M., Jacques, F., Venegas, P., Miranda, M., Barrientos, N., Tenhamm, E., Gloger, S., Rohde, G., Mares, J., Frederiksen, J., Stenager, E., Haldre, S., Gross Paju, K., Elovaara, I., Sumelahti, M. L., Erälinna, J. P., Farkkila, M., Harno, H., Reunanen, M., Jolma, T., Camu, W., Clavelou, P., Magy, L., Debouverie, M., Edan, G., Lebrun Frenay, C., Moreau, T., Pelletier, J., Roullet, E., Alamowitch, S., Clanet, M., Hautecoeur, P., Damier, P., Rumbach, L., Chan, A., Schimrigk, S., Haas, J., Lensch, E., Diener, H., Limmroth, V., Anders, D., Berghoff, M., Oschmann, P., Stangel, M., Frese, A., Kiefer, R., Marziniak, M., Zettl, U., Stark, E., Jendroska, K., Reifschneider, G., Amato, M. P., Cosi, V., Gallo, P., Gasperini, Claudio, Ghezzi, A., Trojano, M., Pozzilli, Carlo, Montanari, E., Zwanikken, C. P., Jongen, P. J., Van Munster, E. T., Hupperts, R. M., Anten, B., Sanders, E. A., Celius, E., Hovdal, H., Krogseth, S. B., Kozubski, W., Kwiecinski, H., Czlonkowska, A., Stelmasiak, Z., Selmaj, K., Hasiec, T., Fryze, W., Drozdowski, W., Kochanowicz, J., Cunha, L., De Sa, J., Sena, A. H., Odinak, M., Skoromets, A., Gusev, E., Boiko, A., Lashch, N., Stolyarov, I., Belova, A., Malkova, N., Doronin, B., Yakupov, E., Brundin, L., Hillert, J., Karabudak, R., Irkec, C., Idiman, E., Turan, O., Efendi, H., Gedizlioglu, M., Buchakchyyska, N., Goloborodko, A., Ipatov, A., Kobets, S., Lebedynets, V., Moskovko, S., Sanotskyy, Y., Smolanka, V., Yavorskaya, V., Bates, D., Evangelou, N., Hawkins, C., Mclean, B., O'Riordan, J., Price, S., Turner, B., Barnes, D., Zajicek, J., Honeycutt, W., Khan, O., Spikol, L., Stevens, J., Klinische Neurowetenschappen, and RS: MHeNs School for Mental Health and Neuroscience
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medicine.medical_specialty ,biology ,Nausea ,business.industry ,Incidence (epidemiology) ,Placebo-controlled study ,General Medicine ,Placebo ,Gastroenterology ,Surgery ,chemistry.chemical_compound ,Alanine transaminase ,chemistry ,Internal medicine ,Relative risk ,Teriflunomide ,medicine ,biology.protein ,medicine.symptom ,business ,Leflunomide ,medicine.drug - Abstract
Teriflunomide reduced the annualized relapse rate (0.54 for placebo vs. 0.37 for teri flunomide at either 7 or 14 mg), with relative risk reductions of 31.2% and 31.5%, respectively (P
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- 2011
19. N-type bi-facial solar cells with boron emitters from doped PECVD layers
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Frey, A., Engelhardt, J., Fritz, S., Gloger, S., Hahn, G., and Terheiden, B.
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WAFER-BASED SILICON SOLAR CELLS AND MATERIALS TECHNOLOGY ,ddc:530 ,Silicon Solar Cell Improvements - Abstract
29th European Photovoltaic Solar Energy Conference and Exhibition; 656-660, This work is mainly focused on an alternative method for emitter formation by means of boron diffusion from a boron-doped plasma-enhanced chemical vapor deposition (PECVD) doping source. With this approach only one high temperature process is necessary for emitter and BSF/FSF formation (co-diffusion), without depletion of surface doping concentration. This enables time and cost-efficient fabrication of solar cells with high conversion efficiencies, as shown in this work, on large area (156.25 cm2) bi-facial devices with conversion efficiencies up to 19.7% measured with white back sheet. Furthermore, the contact formation with screen-printing of silver/aluminum (Ag/Al) pastes and its emitter shunting behavior due to Ag/Al spikes, varying with the firing conditions in a belt furnace, are of major interest. Low contact resistance values below 4 mΩcm2 can be realized with screen-printed Ag/Al contacts on 55-70 Ω/sq PECVD boron emitters. In addition, Ag/Al spikes with a depth of around 1-3 μm could be detected with SEM measurements.
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- 2014
20. Magnetic resonance imaging outcomes from a phase III trial of teriflunomide
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Wolinsky, Js, Narayana, Pa, Nelson, F, Datta, S, O'Connor, P, Confavreux, C, Comi, G, Kappos, L, Olsson, Tp, Truffinet, P, Wang, L, Miller, A, Freedman MSMaida, E, Auff, E, Fazekas, F, Berger, T, Bhan, V, Bouchard, Jp, Duquette, P, Freedman, M, Grand'Maison, F, Kremenchutzky, M, Bourque, C, Marrie, Ra, Melanson, M, Patry, D, Oger, J, Stefanelli, M, Jacques, F, Venegas, P, Miranda, M, Barrientos, N, Tenhamm, E, Gloger, S, Rohde, G, Mares, J, Frederiksen, J, Stenager, E, Haldre, S, Gross Paju, K, Elovaara, I, Sumelahti, Ml, Erälinna, Jp, Färkkilä, M, Harno, H, Reunanen, M, Jolma, T, Camu, W, Clavelou, P, Magy, L, Debouverie, M, Edan, G, Lebrun Frenay, C, Moreau, T, Pelletier, J, Roullet, E, Alamowitch, S, Clanet, M, Hautecoeur, P, Damier, P, Rumbach, L, Chan, A, Schimrigk, S, Haas, J, Lensch, E, Diener, H, Limmroth, V, Anders, D, Berghoff, M, Oschmann, P, Stangel, M, Frese, A, Kiefer, R, Marziniak, M, Zettl, U, Stark, E, Jendroska, K, Reifschneider, G, Amato, Mp, Cosi, V, Gallo, Paolo, Gasperini, C, Ghezzi, A, Trojano, M, Pozzilli, C, Montanari, E, Zwanikken, Cp, Jongen, Pj, Centrum, Ms, Van Munster ET, Hupperts, Rm, Anten, B, Sanders, Ea, Celius, E, Hovdal, H, Krogseth, Sb, Kozubski, W, Kwiecinski, H, Czlonkowska, A, Stelmasiak, Z, Selmaj, K, Hasiec, T, Fryze, W, Drozdowski, W, Kochanowicz, J, Cunha, L, De Sá, J, Harrington Sena, A, Odinak, M, Skoromets, A, Gusev, E, Boiko, A, Lashch, N, Stolyarov, I, Belova, A, Malkova, N, Doronin, B, Yakupov, E, Brundin, L, Hillert, J, Karabudak, R, Irkec, C, Idiman, E, Turan, O, Efendi, H, Gedizlioglu, M, Buchakchyyska, N, Goloborodko, A, Ipatov, A, Kobets, S, Lebedynets, V, Moskovko, S, Yushchenko, Oi, Sanotskyy, Y, Smolanka, V, Yavorskaya, V, Bates, D, Evangelou, N, Hawkins, C, Mclean, B, O'Riordan, J, Price, S, Turner, B, Barnes, D, Zajicek, J, Honeycutt, W, Khan, O, Spikol, L, and Stevens, J.
- Published
- 2013
21. Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis
- Author
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O'Connor, P, Wolinsky, Js, Confavreux, C, Comi, G, Kappos, L, Olsson, Tp, Benzerdjeb, H, Truffinet, P, Wang, L, Miller, A, Freedman, Ms, Reingold, S, Cutter, G, Antel, J, Barkhof, F, Maddrey, W, Ravnborg, M, Schenker, S, Narayana, Pa, Nelson, F, Vainrub, I, Datta, S, He, R, Gates, B, Ton, K, Wamil, B, Igau, B, Nicolas, V, Notelet, L, Payrard, S, Wijnand, P, Devore, S, Li, Hh, Osho, T, Wei, L, Dukovic, D, Ling, Y, Mednikova, Z, Trabelsi, N, Musset, M, Merrill, D, Turpault, S, Williams, B, Nortmeyer, H, Kirst, E, Witthaus, E, Chen, S, Maida, E, Auff, E, Fazekas, F, Berger, T, Bhan, V, Bouchard, Jp, Duquette, P, Grand'Maison, F, Kremenchutzky, M, Bourque, C, Marrie, Ra, Melanson, M, Patry, D, Oger, J, Stefanelli, M, Jacques, F, Venegas, P, Miranda, M, Barrientos, N, Tenhamm, E, Gloger, S, Rohde, G, Mares, J, Frederiksen, J, Stenager, E, Haldre, S, Gross Paju, K, Elovaara, I, Sumelahti, Ml, Erälinna, Jp, Färkkilä, M, Harno, H, Reunanen, M, Jolma, T, Camu, W, Clavelou, P, Magy, L, Debouverie, M, Edan, G, Lebrun Frenay, C, Moreau, T, Pelletier, J, Roullet, E, Alamowitch, S, Clanet, M, Hautecoeur, P, Damier, P, Rumbach, L, Chan, A, Schimrigk, S, Haas, J, Lensch, E, Diener, H, Limmroth, V, Anders, D, Berghoff, M, Oschmann, P, Stangel, M, Frese, A, Kiefer, R, Marziniak, M, Zettl, U, Stark, E, Jendroska, K, Reifschneider, G, Amato, Mp, Cosi, V, Gallo, Paolo, Gasperini, C, Ghezzi, A, Trojano, M, Pozzilli, C, Montanari, E, Zwanikken, Cp, Jongen, Pj, Van Munster ET, Hupperts, Rm, Anten, B, Sanders, Ea, Celius, E, Hovdal, H, Krogseth, Sb, Kozubski, W, Kwiecinski, H, Czlonkowska, A, Stelmasiak, Z, Selmaj, K, Hasiec, T, Fryze, W, Drozdowski, W, Kochanowicz, J, Cunha, L, De Sá, J, Sena, Ah, Odinak, M, Skoromets, A, Gusev, E, Boiko, A, Lashch, N, Stolyarov, I, Belova, A, Malkova, N, Doronin, B, Yakupov, E, Brundin, L, Hillert, J, Karabudak, R, Irkec, C, Idiman, E, Turan, O, Efendi, H, Gedizlioglu, M, Buchakchyyska, N, Goloborodko, A, Ipatov, A, Kobets, S, Lebedynets, V, Moskovko, S, Sanotskyy, Y, Smolanka, V, Yavorskaya, V, Bates, D, Evangelou, N, Hawkins, C, Mclean, B, O'Riordan, J, Price, S, Turner, B, Barnes, D, Zajicek, J, Honeycutt, W, Khan, O, Spikol, L, and Stevens, J.
- Published
- 2011
22. Investigation of the back side passivation layer of screen printed bifacial silicon solar cells
- Author
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Gloger, S., Riegel, S., Raabe, B., and Hahn, G.
- Subjects
Passivation ,Mono- and Multicrystalline Silicon Materials and Cells ,ddc:530 ,Back-surface-field ,Wafer-based Silicon Solar Cells and Materials Technology ,Bifacial - Abstract
24th European Photovoltaic Solar Energy Conference, 21-25 September 2009, Hamburg, Germany; 1544-1547, This work compares the back side passivation quality of bifacial silicon (Si) solar cells with boron back-surface-field (B-BSF) of different sheet resistances. The influence of the thickness of an additional dry thermal silicon dioxide (SiO2) to passivate the surface of the B-BSF is also investigated. The passivation quality is compared in two experiments: First Si lifetime samples with boron (B) emitter are passivated and their emitter saturation current densities (J0E) are determined with quasi-steady-state photoconductance (QSSPC) measurements after every process step. Secondly large area bifacial solar cells with different base doping are processed. The cell parameters are determined by illuminated current-voltage (IV) characteristics and the effective minority charge carrier diffusion lengths (Leff) are calculated with a model [1] using the internal quantum efficiencies (IQE) from spectral response measurements. The optimum B-BSF sheet resistance for the bifacial cell concept used is found to be 60 Ohm/sq. The optimum value of the thickness of the SiO2 layer for additional surface passivation is found to be in the range of 19- 30 nm dependent on the base doping.
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- 2009
23. Aromatase Inhibition Abolishes LTP Generation in Female But Not in Male Mice
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Vierk, R., primary, Glassmeier, G., additional, Zhou, L., additional, Brandt, N., additional, Fester, L., additional, Dudzinski, D., additional, Wilkars, W., additional, Bender, R. A., additional, Lewerenz, M., additional, Gloger, S., additional, Graser, L., additional, Schwarz, J., additional, and Rune, G. M., additional
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- 2012
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24. Subacute Liver Failure Induced by Phenprocoumon Treatment
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Mix, H., primary, Wagner, S., additional, Böker, K., additional, Gloger, S., additional, Oldhafer, K.J., additional, Behrend, M., additional, Flemming, P., additional, and Manns, M.P., additional
- Published
- 1999
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25. Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor
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RICE, Q. J. Simon, primary, SOUTHAN, Christopher, additional, BOYD, F. Helen, additional, TERRETT, A. Jonathan, additional, MACPHEE, H. Colin, additional, MOORES, Kitty, additional, GLOGER, S. Israel, additional, and TEW, G. David, additional
- Published
- 1998
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26. Treatment of spontaneous panic attacks with chlomipramine
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Troudart T, Leon Grunhaus, Gloger S, and B Birmacher
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Adult ,Male ,medicine.medical_specialty ,behavioral disciplines and activities ,Asymptomatic ,Pharmacological treatment ,Treatment plan ,mental disorders ,Chlomipramine ,medicine ,Humans ,Psychiatry ,Agoraphobia ,business.industry ,Panic disorder ,Panic ,Middle Aged ,medicine.disease ,Anxiety Disorders ,humanities ,Psychiatry and Mental health ,Phobic Disorders ,Clomipramine ,Female ,medicine.symptom ,business - Abstract
Recurrent spontaneous panic attacks are psychophysiological symptoms present in panic disorder and agoraphobia with panic attacks. Effective pharmacological treatment for panic attacks is essential to any treatment plan for these conditions. The authors administered chlomipramine to 20 patients who had panic disorder or agoraphobia with panic attacks, and after 8 weeks of treatment 75% of the patients with each diagnosis were asymptomatic. These results support the claim that chlomipramine is highly effective in preventing recurrence of panic attacks.
- Published
- 1981
27. Reduction of hazards and stress during travel underground.
- Author
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Bier M., Gloger S., Mucher F., Potsch J., Rohmert W., Suciu M., Vollmer M., Bier M., Gloger S., Mucher F., Potsch J., Rohmert W., Suciu M., and Vollmer M.
- Abstract
A systematic analysis of underground travel has shown the interactions of spatial conditions, ambient conditions, auxiliary equipment and physical stress. The hazards and stresses which can occur for workers travelling on foot depend on dips, floor conditions and the speed of travel. Hazards and stresses can be reduced by transporting workers in vehicles., A systematic analysis of underground travel has shown the interactions of spatial conditions, ambient conditions, auxiliary equipment and physical stress. The hazards and stresses which can occur for workers travelling on foot depend on dips, floor conditions and the speed of travel. Hazards and stresses can be reduced by transporting workers in vehicles.
28. A1046 - Robotic partial nephrectomy in patients with a solitary kidney – a multicenter analysis.
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Katzendorn, O., Faraj Tabrizi, P., Schiefelbein, F., Schoen, G., Wiesinger, C., Pfuner, J., Ubrig, B., Gloger, S., Nuhn, P., Eraky, A., Wagner, C., Ayanle, A., Kesch, C., Al-Nader, M., Hadaschik, B.A., Fuhrmann, C., Kuczyk, M.A., Siemer, S., Stöckle, M., and Zeuschner, P.
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- *
NEPHRECTOMY , *KIDNEYS , *ROBOTICS , *PATIENTS - Published
- 2024
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29. A0626 - Urinary fistulae after robotic partial nephrectomy – analysis of a multicenter database.
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Fuhrmann, C., Katzendorn, O., Schiefelbein, F., Schoen, G., Wiesinger, C., Pfuner, J., Ubrig, B., Gloger, S., Nuhn, P., Eraky, A., Wagner, C., Ayanle, A., Kesch, C., Al-Nader, M., Hadaschik, B.A., Kuczyk, M.A., Faraj Tabrizi, P., Siemer, S., Stöckle, M., and Zeuschner, P.
- Subjects
- *
URINARY fistula , *DATABASES , *NEPHRECTOMY , *ROBOTICS - Published
- 2024
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30. A0125 - Impact of surgical experience prior to robot-assisted partial nephrectomy on surgical outcomes: Large multicenter analysis with 2,500 patients.
- Author
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Zeuschner, P., Siemer, S., Stöckle, M., Schiefelbein, F., Schneller, A., Schön, G., Wiesinger, C., Pfuner, J., Ubrig, B., Gloger, S., Osmonov, D., Eraky, A., Witt, J., Liakos, N., Wagner, C., Hadaschik, B., Radtke, J.P., Al Nader, M., Imkamp, F., and Kuczyk, M.
- Subjects
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SURGICAL robots , *NEPHRECTOMY , *PATIENTS - Published
- 2022
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31. Perioperative Rates of Incidental Prostate Cancer after Aquablation and Holmium Laser Enucleation of the Prostate.
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Gloger S, Paulics L, Philippou C, Philippou S, Witt JH, and Ubrig B
- Abstract
Introduction: Aquablation and holmium laser enucleation of the prostate (HoLEP) have evolved as established therapeutic options for men with benign prostatic obstruction (BPO). We sought to compare the rates of incidental prostate cancer (iPCa) after aquablation and HoLEP., Methods: At our center, between January 2020 and November 2022, 317 men underwent aquablation, and 979 men underwent HoLEP for BPO. Histopathological assessment of resected tissue was conducted in all cases. If iPCa was detected, the Gleason score and percentage of affected tissue were assessed. Differences in important predictive factors for prostate cancer between study groups were accounted for by additional matched pairs analysis (with matching on age ± 1 year; PSA ± 0.5 ng/mL; and prostate volume ± 5 mL)., Results: Histopathology revealed iPCas in 60 patients (4.6%): 59 (6.03%) after HoLEP and 1 (0.3%) after aquablation (p = 0.001). Of 60 of incidental cancers, 11 had a Gleason score ≥7 (aquablation: 1/1 [100%]; HoLEP: 10/59 [16.9%]). The aquablation and HoLEP study groups differed in patient age, preoperative PSA, and prostate volume. Therefore, matched pairs analysis (aquablation: 132 patients; HoLEP: 132 patients) was conducted to improve comparability. Also after the matching procedure, significantly fewer iPCas were diagnosed after aquablation than HoLEP (aquablation: 0 [0%]; HoLEP: 6 [4.5%]; p = 0.015)., Conclusion: Significantly fewer iPCas were identified after aquablation than HoLEP procedures. Histopathologic assessment of tissue after aquablation is feasible and may lead to the diagnosis of clinically significant iPCa. Therefore, histopathologic examination of the aquablation resective tissue should not be omitted., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
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- 2024
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32. Peritoneal Interposition Flap: An Updated Meta-Analysis of Six Randomized Controlled Trials Revealing Consistent Reduction of Symptomatic Lymphoceles Following Robot-Assisted Radical Prostatectomy and Pelvic Lymph Node Dissection.
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May M, Gloger S, and Wolff I
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- Humans, Male, Lymph Node Excision methods, Peritoneum surgery, Peritoneum pathology, Postoperative Complications etiology, Randomized Controlled Trials as Topic, Robotic Surgical Procedures methods, Lymphocele etiology, Lymphocele surgery, Pelvis surgery, Pelvis pathology, Prostatectomy methods, Prostatectomy adverse effects, Surgical Flaps
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- 2024
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33. The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.
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Dalmasso MC, de Rojas I, Olivar N, Muchnik C, Angel B, Gloger S, Sanchez Abalos MS, Chacón MV, Aránguiz R, Orellana P, Cuesta C, Galeano P, Campanelli L, Novack GV, Martinez LE, Medel N, Lisso J, Sevillano Z, Irureta N, Castaño EM, Montrreal L, Thoenes M, Hanses C, Heilmann-Heimbach S, Kairiyama C, Mintz I, Villella I, Rueda F, Romero A, Wukitsevits N, Quiroga I, Gona C, Lambert JC, Solis P, Politis DG, Mangone CA, Gonzalez-Billault C, Boada M, Tàrraga L, Slachevsky A, Albala C, Fuentes P, Kochen S, Brusco LI, Ruiz A, Morelli L, and Ramírez A
- Subjects
- Humans, Chile, Genetic Predisposition to Disease genetics, Polymorphism, Single Nucleotide genetics, Genome-Wide Association Study, Alzheimer Disease genetics, Azides
- Abstract
Introduction: Genome-wide association studies (GWAS) are fundamental for identifying loci associated with diseases. However, they require replication in other ethnicities., Methods: We performed GWAS on sporadic Alzheimer's disease (AD) including 539 patients and 854 controls from Argentina and Chile. We combined our results with those from the European Alzheimer and Dementia Biobank (EADB) in a meta-analysis and tested their genetic risk score (GRS) performance in this admixed population., Results: We detected apolipoprotein E ε4 as the single genome-wide significant signal (odds ratio = 2.93 [2.37-3.63], P = 2.6 × 10
-23 ). The meta-analysis with EADB summary statistics revealed four new loci reaching GWAS significance. Functional annotations of these loci implicated endosome/lysosomal function. Finally, the AD-GRS presented a similar performance in these populations, despite the score diminished when the Native American ancestry rose., Discussion: We report the first GWAS on AD in a population from South America. It shows shared genetics modulating AD risk between the European and these admixed populations., Highlights: This is the first genome-wide association study on Alzheimer's disease (AD) in a population sample from Argentina and Chile. Trans-ethnic meta-analysis reveals four new loci involving lysosomal function in AD. This is the first independent replication for TREM2L, IGH-gene-cluster, and ADAM17 loci. A genetic risk score (GRS) developed in Europeans performed well in this population. The higher the Native American ancestry the lower the GRS values., (© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)- Published
- 2024
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34. Impact of Peritoneal Interposition Flap on Patients Undergoing Robot-assisted Radical Prostatectomy and Pelvic Lymph Node Dissection: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
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May M, Gilfrich C, Bründl J, Ubrig B, Wagner JR, Gloger S, Student V Jr, Merseburger AS, Thomas C, Brookman-May SD, and Wolff I
- Abstract
Context: Symptomatic lymphocele (sLC) occurs at a frequency of 2-10% after robot-assisted radical prostatectomy (RARP) with pelvic lymph node dissection (PLND). Construction of bilateral peritoneal interposition flaps (PIFs) subsequent to completion of RARP + PLND has been introduced to reduce the risk of lymphocele, and was initially evaluated on the basis of retrospective studies., Objective: To conduct a systematic review and meta-analysis of only randomized controlled trials (RCTs) evaluating the impact of PIF on the rate of sLC (primary endpoint) and of overall lymphocele (oLC) and Clavien-Dindo grade ≥3 complications (secondary endpoints) to provide the best available evidence., Evidence Acquisition: In accordance with the Preferred Reporting Items for Meta-Analyses statement for observational studies in epidemiology, a systematic literature search using the MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE databases up to February 3, 2023 was performed to identify RCTs. The risk of bias (RoB) was assessed using the revised Cochrane RoB tool for randomized trials. Meta-analysis used random-effect models to examine the impact of PIF on the primary and secondary endpoints., Evidence Synthesis: Four RCTs comparing outcomes for patients undergoing RARP + PLND with or without PIF were identified: PIANOFORTE, PerFix, ProLy, and PLUS. PIF was associated with odds ratios of 0.46 (95% confidence interval [CI] 0.23-0.93) for sLC, 0.51 (95% CI 0.38-0.68) for oLC, and 0.41 (95% CI 0.21-0.83) for Clavien-Dindo grade ≥3 complications. Functional impairment resulting from PIF construction was not observed. Heterogeneity was low to moderate, and RoB was low., Conclusions: PIF should be performed in patients undergoing RARP and simultaneous PLND to prevent or reduce postoperative sLC., Patient Summary: A significant proportion of patients undergoing prostate cancer surgery have regional lymph nodes removed. This part of the surgery is associated with a risk of postoperative lymph collections (lymphocele). The risk of lymphocele can be halved via a complication-free surgical modification called a peritoneal interposition flap., (Copyright © 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
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- 2024
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35. Early adverse stress and depression severity: A pilot exploration of mediating psychological mechanisms.
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Martínez P, Gloger S, Dagnino P, and de Medina DD
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Objective: To explore the associations between early adverse stress, attachment insecurity in adulthood (anxious and avoidant), pathological personality styles (self-criticism and dependency), difficulties in emotion regulation, and depression severity., Methods: Cross-sectional study of 178 outpatients diagnosed with major depression in Santiago, Chile. Participants filled the Childhood Trauma Questionnaire Short Form, the Experience in Close Relationships Scale, the Depressive Experience Questionnaire, the Difficulties in Emotion Regulation Scale, and the Patient Health Questionnaire-9 item. Full-information maximum likelihood path analyses with bias-corrected bootstrapped confidence intervals were conducted., Results: Anxious attachment in adulthood and self-criticism mediated the association between early adverse stress and depression severity through their effects on difficulties in emotion regulation. Early adverse stress was not associated with avoidant attachment in adulthood and dependency; these variables were indirectly associated with depression severity. Difficulties in emotion regulation were exclusively directly related to depression severity, mediating the effects of the preceding variables., Conclusions: Our findings propose an integrative model for psychological mechanisms mediating between early adverse stress and depression. Difficulties in emotion regulation should be considered when treating adults with depression exposed to early adverse stress. The contribution of specific types of early adverse stressors and difficulties in emotion regulation should be further explored.
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- 2023
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36. High BMI and Surgical Time Are Significant Predictors of Lymphocele after Robot-Assisted Radical Prostatectomy.
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Gloger S, Wagner C, Leyh-Bannurah SR, Siemer S, Arndt M, Stolzenburg JU, Franz T, and Ubrig B
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Lymphoceles (LC) occur in up to 60% after robot-assisted radical prostatectomy (RARP) and pelvic lymphadenectomy (PLND). In 2-10%, they are symptomatic and may cause complications and require treatment. Data on risk factors for the formation of lymphoceles after RARP and PNLD remain sparse in the urologic literature and are inconclusive to date. The underlying data of this secondary analysis were obtained from the prospective multi-center RCT ProLy. We performed a multivariate analysis to focus on the potential risk factors that may influence lymphocele formation. Patients with LC had a statistically significant higher BMI (27.8 vs. 26.3 kg/m
2 , p < 0.001; BMI ≥ 30 kg/m2 : 31 vs. 17%, p = 0.002) and their surgical time was longer (180 vs. 160 min, p = 0.001) In multivariate analysis, the study group (control vs. peritoneal flap, p = 0.003), BMI (metric, p = 0.028), and surgical time (continuous, p = 0.007) were independent predictors. Patients with symptomatic lymphocele presented with higher BMI (29 vs. 26.6 kg/m2 , p = 0.007; BMI ≥ 30 kg/m2 : 39 vs. 20%, p = 0.023) and experienced higher intraoperative blood loss (200 vs. 150 mL, p = 0.032). In multivariate analysis, BMI ≥ 30 kg/m2 vs. < 30 kg/m2 was an independent predictor for the formation of a symptomatic lymphocele ( p = 0.02). High BMI and prolonged surgical time are general risk factors for the development of LC. Patients with a BMI ≥ 30 kg/m2 had a higher risk for symptomatic lymphoceles., Competing Interests: Ubrig: Intuitive Surgery, Procept Biorobotics. Siemer: Intuitive Surgery. The other authors declare no conflicts of interest.- Published
- 2023
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37. Bilateral Peritoneal Flaps Reduce Incidence and Complications of Lymphoceles After Robotic Radical Prostatectomy With Pelvic Lymph Node Dissection-Results of the Prospective Randomized Multicenter Trial ProLy. Reply.
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Gloger S, Ubrig B, Boy A, Leyh-Bannurah SR, Siemer S, Arndt M, Stolzenburg JU, Franz T, Oelke M, and Witt JH
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- Humans, Male, Prospective Studies, Prostate, Lymph Node Excision adverse effects, Seminal Vesicles, Prostatectomy adverse effects
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- 2023
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38. Impact of Surgical Experience Before Robot-assisted Partial Nephrectomy on Surgical Outcomes: A Multicenter Analysis of 2500 Patients.
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Harke NN, Kuczyk MA, Huusmann S, Schiefelbein F, Schneller A, Schoen G, Wiesinger C, Pfuner J, Ubrig B, Gloger S, Osmonov D, Eraky A, Witt JH, Liakos N, Wagner C, Hadaschik BA, Radtke JP, Al Nader M, Imkamp F, Siemer S, Stöckle M, and Zeuschner P
- Abstract
Background: Robot-assisted partial nephrectomy (RAPN) is a challenging procedure that is influenced by a multitude of factors., Objective: To assess the impact of prior surgical experience on perioperative outcomes in RAPN., Design Setting and Participants: In this retrospective multicenter study, results for 2548 RAPNs performed by 25 surgeons at eight robotic referral centers were analyzed. Perioperative data for all consecutive RAPNs from the start of each individual surgeon's experience were collected, as well as the number of prior open or laparoscopic kidney surgeries, pelvic surgeries (open, laparoscopic, robotic), and other robotic interventions., Intervention: Transperitoneal or retroperitoneal RAPN., Outcome Measurements and Statistical Analysis: The impact of prior surgical experience on operative time, warm ischemia time (WIT), major complications, and margin, ischemia, complication (MIC) score (negative surgical margins, WIT ≤20 min, no major complications) was assessed via univariate and multivariable regression analyses accounting for age, gender, body mass index (BMI), American Society of Anesthesiologists score, PADUA score, and RAPN experience., Results and Limitations: BMI, PADUA score, and surgical experience in RAPN had a strong impact on perioperative outcomes. A plateau effect for the learning curve was not observed. Prior laparoscopic kidney surgery significantly reduced the operative time ( p < 0.001) and WIT ( p < 0.001) and improved the MIC rate ( p = 0.022). A greater number of prior robotic pelvic interventions decreased WIT ( p = 0.011) and the rate of major complications ( p < 0.001) and increased the MIC rate ( p = 0.011), while prior experience in open kidney surgery did not. One limitation is the short-term follow-up., Conclusions: Mastering of RAPN is an ongoing learning process. However, prior experience in laparoscopic kidney and robot-assisted pelvic surgery seems to improve perioperative outcomes for surgeons when starting with RAPN, while experience in open surgery might not be crucial., Patient Summary: In this multicenter analysis, we found that a high degree of experience in keyhole kidney surgery and robot-assisted pelvic surgery helps surgeons in achieving good initial outcomes when starting robot-assisted kidney surgery., (© 2022 The Author(s).)
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- 2022
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39. Bilateral Peritoneal Flaps Reduce Incidence and Complications of Lymphoceles after Robotic Radical Prostatectomy with Pelvic Lymph Node Dissection-Results of the Prospective Randomized Multicenter Trial ProLy.
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Gloger S, Ubrig B, Boy A, Leyh-Bannurah SR, Siemer S, Arndt M, Stolzenburg JU, Franz T, Oelke M, and Witt JH
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- Humans, Incidence, Lymph Node Excision adverse effects, Lymph Node Excision methods, Male, Pelvis, Peritoneum surgery, Prospective Studies, Prostatectomy adverse effects, Prostatectomy methods, Lymphocele epidemiology, Lymphocele etiology, Lymphocele prevention & control, Prostatic Neoplasms pathology, Robotic Surgical Procedures adverse effects, Robotic Surgical Procedures methods, Robotics
- Abstract
Purpose: The purpose of this study was to investigate the effect of a surgically constructed bilateral peritoneal flap (PIF) as an adjunct to robot-assisted radical prostatectomy (RARP) and pelvic lymph node dissection (PLND) on the incidence of lymphoceles., Materials and Methods: A total of 530 men with localized prostate cancer underwent a RARP with bilateral extended standardized PLND in a prospective randomized controlled trial. In group A, a PIF was created by suturing the margins of the bladder peritoneum to the ipsilateral endopelvic fascia at 2 points on each side. In group B, no PIF was created. The patients were followed 30 and 90 days after the surgery to assess the incidence, extent and treatment of lymphoceles., Results: Lymphoceles occurred in 22% of group A patients and 33% of group B patients (p=0.008). Symptomatic lymphoceles were observed in 3.3% of group A patients and 8.1% of group B patients (p=0.027). Lymphoceles requiring intervention occurred significantly less frequently in group A patients (1.3%) than in group B patients (6.8%, p=0.002). The median lymphocele size was 4.3 cm in group A and 5.0 cm in group B (p=0.055). No statistically significant differences were observed in minor or major complications unrelated to lymphocele, blood loss, or surgical time between groups A and B., Conclusions: Bilateral PIFs in conjunction with RARP and PLND significantly reduce the total incidence of lymphoceles, the frequency of symptomatic lymphoceles and the rate of associated secondary interventions.
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- 2022
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40. An Adjunctive Internet-Based Intervention to Enhance Treatment for Depression in Adults: Randomized Controlled Trial.
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Pérez JC, Fernández O, Cáceres C, Carrasco ÁE, Moessner M, Bauer S, Espinosa-Duque D, Gloger S, and Krause M
- Abstract
Background: Internet-based interventions promise to enhance the accessibility of mental health care for a greater number of people and in more remote places. Their effectiveness has been shown for the prevention and treatment of various mental disorders. However, their potential when delivered as add-on to conventional treatment (ie, blended care) is less clear., Objective: The aim of this study is to study the effectiveness of an internet intervention (ASCENSO) implemented in addition to face-to-face treatment as usual (TAU) for depression., Methods: A 2-arm, parallel-group, randomized controlled trial was conducted in an outpatient private mental health care center in Chile. In all, 167 adults, diagnosed with major depressive disorder, without severe comorbidities, and with internet access, were included. Eighty-four participants were assigned to the intervention group and received medical and psychological TAU from the mental health center plus access to the ASCENSO online platform. The control group (n=83) received only TAU. The ASCENSO platform includes psycho-educational information, depressive symptom monitoring and feedback, and managing emergencies based on the principles of cognitive behavioral therapy. Emergency management was mental health provider-assisted. TAU includes access to primary care physicians and psychiatrists, to a brief individual psychotherapy, and to medication when needed. The baseline questionnaires were administered in person, and 6- and 9-months assessments were conducted online. Depression symptoms and quality of life were measured by self-administered questionnaires, and treatment adherence was determined via the Mental Health Center's internal records. The usage of ASCENSO was assessed by server logs. Reduction on depressive symptomatology was considered as the primary outcome of the intervention and quality of life as a secondary outcome., Results: Of the 84 participants in the intervention group, 5 participants (6%) never accessed the online platform. Of the remaining 79 participants who accessed ASCENSO, 1 (1%, 1/79) did not answer any of the symptom questionnaire, and most participants (72/79, 91%) answered the monitoring questionnaires irregularly. The ASCENSO intervention implemented in addition to face-to-face care did not improve the outcome of the usual care delivered at the mental health center, either in terms of reduction of depressive symptoms (F
2,6087 = 0.48; P=.62) or in the improvement of quality of life (EQ-5D-3L: F2,7678 =0.24; P=.79 and EQ-VAS: F2,6670 = 0.13; P=.88). In contrast, for the primary (F2,850 =78.25; P<.001) and secondary outcomes (EQ-5D-3L: F2,1067 =37.87; EQ-VAS: F2,4390 = 51.69; P<.001) in both groups, there was an improvement from baseline to 6 months (P<.001), but there was no change at 9 months. In addition, no effects on adherence to or use of TAU were found. Finally, the dropout rate for the face-to-face treatment component was 54% (45/84) for the intervention group versus 39% (32/83) for the control group (P=.07)., Conclusions: The fact that the adjunctive access to ASCENSO did not improve outcome could be due to both the rather high effectiveness of TAU and to patients' limited use of the online platform., Trial Registration: ClinicalTrials.gov NCT03093467; https://clinicaltrials.gov/ct2/show/NCT03093467., (©J Carola Pérez, Olga Fernández, Cristián Cáceres, Álvaro E Carrasco, Markus Moessner, Stephanie Bauer, Daniel Espinosa-Duque, Sergio Gloger, Mariane Krause. Originally published in JMIR Mental Health (https://mental.jmir.org), 16.12.2021.)- Published
- 2021
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41. [Systematic review of treatment alternatives for depressed adults with early adverse stress].
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Martínez P, Gloger S, Diez de Medina D, González A, Carrasco MI, and Vöhringer PA
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- Adult, Anxiety, Humans, Mental Health, Treatment Outcome, Mental Disorders psychology, Quality of Life
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Background: Early adverse stress is a risk factor for the appearance of mental health ailments during adulthood., Aim: To systematically review treatment outcomes on mental health symptoms and functional domains, and of interventions aimed at treating adults with depressive disorders and early adverse stress (EAS)., Material and Methods: Systematic review and meta-analysis including experimental and quasi-experimental published studies indexed in the CINAHL, EMBASE, PubMed, and Web of Science databases, which explored the effectiveness of treatment interventions for depressive disorders in adults exposed to EAS. Data on outcomes was extracted from the included studies. A narrative, qualitative approach or a quality-effects model for meta-analysis were used for synthesizing these data., Results: Thirteen studies were included. Psychological or combined treatment interventions for depression in adults exposed to EAS may be effective in reducing trauma-related symptoms and social dysfunction in the short-and mid-term, with small effect size and without substantive heterogeneity. The assessment of anxiety symptoms and health-related quality of life yielded mixed results., Conclusions: Despite the ubiquity of EAS and its adverse and long-lasting consequences for well-being and health, treatment alternatives are scant. This review suggests that there are treatment interventions for depression in adults exposed to EAS that may achieve integral mental health benefits, alleviating its impact on various symptoms and functional domains, when EAS is explicitly considered in the treatment intervention.
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- 2021
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42. Aquablation with subsequent selective bipolar cauterization versus holmium laser enucleation of the prostate (HoLEP) with regard to perioperative bleeding.
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Gloger S, Schueller L, Paulics L, Bach T, and Ubrig B
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- Cautery, Humans, Male, Prostate surgery, Retrospective Studies, Treatment Outcome, Laser Therapy, Lasers, Solid-State adverse effects, Prostatic Hyperplasia complications, Prostatic Hyperplasia surgery, Transurethral Resection of Prostate
- Abstract
Introduction: To compare the surgical methods of Aquablation followed by selective hemostasis by bipolar cauterization with holmium laser enucleation of the prostate (HoLEP) with regard to the risk of perioperative bleeding complications., Materials and Methods: A retrospective comparison was carried out on a total of 382 patients who had undergone either Aquablation (n = 167) or HoLEP (n = 215) at our hospital between April 2018 and July 2020. The following were studied: Hb loss, the need for packed red blood cell transfusions and surgical revisions due to bleeding from the prostatic fossa., Results: Transfusions were not necessary in the Aquablation group, while one man who underwent HoLEP had to receive a transfusion. Revision surgery due to bleeding was necessary during the early postoperative course in 13.2% of Aquablations and in 9.8% of HoLEPs (statistically not significant; p = 0.329). The perioperative Hb loss was comparable in both entire collectives (Aquablation 1.37 +/- 1.13 mg/dL, HoLEP 1.22 +/- 1.03 mg/dL; statistically not significant; p = 0.353). For subgroup analysis the groups Aquablation and HoLEP were into three subgroups respectively according to sonographically determined preoperative prostate volume ('small' < 40 mL, 'medium' 41-80 mL, 'large' > 80 mL). There were no significant differences between the subgroups regarding need for transfusions and hematuria-related complications., Conclusions: The rate of perioperative hematuria related complications of Aquablation with subsequent selective hemostasis equals those found after holmium laser enucleation.
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- 2021
43. Early Adverse Stress and Depressive and Bipolar Disorders: A Systematic Review and Meta-Analysis of Treatment Interventions.
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Martínez P, Gloger S, Diez de Medina D, González A, Carrasco MI, Schilling S, and Vöhringer PA
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Introduction: A significant proportion of adults with depressive or bipolar disorders exposed to early adverse stressors do not adequately respond to standard treatments. This review aimed at synthesizing the evidence on the effectiveness of treatment interventions for depressive or bipolar disorders in adult individuals (aged 18 years or more) exposed to adverse stress early in life. Methods: Systematic review and meta-analysis including experimental and quasi-experimental published studies indexed in CINAHL, EMBASE, PubMed, and Web of Science databases and/or in reference lists. Data management and critical appraisal (with the Study Quality Assessment Tools) was conducted independently by multiple researchers. A quality-effects model for meta-analysis was used for data synthesis and publication bias was assessed using the Doi plot and LFK index. The main outcome was short-term reductions in depressive symptoms. Results: Eight randomized controlled trials, three controlled before-and-after (pre-post) studies, and three uncontrolled before-and-after studies were included. Studies lacked bipolar disorder patients. Unclear randomization procedures and reporting of blinded outcome assessor, and limited use of intention-to-treat analysis, were relevant potential sources of bias. Meta-analyses indicated that psychological, pharmacological, and combined interventions were effective in reducing depressive symptoms in the short- (Cohen's d = -0.55, 95% CI -0.75 to -0.36, I = 0%) and mid-term (Cohen's
2 = 0%) and mid-term (Cohen's d = -0.66, 95% CI -1.07 to -0.25, I2 = 65.0%). However, a high risk of publication bias was detected for these outcomes. A small number of studies, with mixed results, reported interventions with long-term improvements in depressive symptomatology, and short- and mid-term response to treatment and remission. Conclusion: Despite the well-documented long-lasting, negative, and costly impact of early adverse stressors on adult psychopathology, evidence on treatment alternatives remains scant. Trauma-focused treatment interventions-whether psychological interventions alone or in combination with pharmacotherapy-may have the potential to reduce the severity of depressive symptom in adults who were exposed to early adverse stress. Findings must be interpreted with considerable caution, as important study and outcome-level limitations were observed and gray literature was not considered in this systematic review and meta-analysis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Martínez, Gloger, Diez de Medina, González, Carrasco, Schilling and Vöhringer.)- Published
- 2021
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44. The contribution of early adverse stress to complex and severe depression in depressed outpatients.
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Gloger S, Vöhringer PA, Martínez P, Chacón MV, Cáceres C, Diez de Medina D, Cottin M, and Behn A
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- Adult, Cross-Sectional Studies, Depression, Humans, Outpatients, Risk Factors, Suicidal Ideation, Depressive Disorder, Major epidemiology
- Abstract
Background: To assess whether linear effects or threshold effects best describe the association between early adverse stress (EAS) and complex and severe depression (i.e., depression with treatment resistance, psychotic symptoms, and/or suicidal ideation), and to examine the attributable risk of complex and severe depression associated with EAS., Methods: A cross-sectional study was conducted using deidentified clinical data (on demographics, presence of complex and severe depression, and exposure to seven types of EAS) from 1,013 adults who were seen in an outpatient mental health clinic in Santiago, Chile, for a major depressive episode. Multivariate logistic regressions were fitted to estimate odds ratios (ORs), using a bootstrap approach to compute 95% bias-corrected confidence intervals (95% BC CIs). A detailed examination of the cumulative risk score and calculations of the attributable risk was conducted., Results: Exposure to at least five EASs was reported by 3.6% of the sample. In the multivariate logistic regression models, there was a marked increase in the odds of having complex and severe depression associated with exposure to at least five EASs (OR = 4.24; 95% BC CI: 1.25 to 9.09), according to a threshold effect. The attributable risk of complex and severe depression associated with exposure to at least one EAS was 36.8% (95% BC CI: 17.7 to 55.9)., Conclusions: High levels of EAS distinctively contribute to complex clinical presentations of depression in adulthood. Patients with complex clinical presentations of depression and history of EAS should need a differentiated treatment approach, particularly those having high levels of EAS., (© 2021 Wiley Periodicals LLC.)
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- 2021
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45. Population-attributable risk of adverse childhood experiences for high suicide risk, psychiatric admissions, and recurrent depression, in depressed outpatients.
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Gloger S, Martínez P, Behn A, Chacón MV, Cottin M, Diez de Medina D, and Vöhringer PA
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Background : Population-attributable risk (PAR) may help estimate the potential contribution of adverse childhood experiences (ACEs) to serious clinical presentations of depression, characterized by suicidality, previous psychiatric admissions, and episode recurrence. Objective : To determine the PAR of ACEs for serious clinical presentations of depression (high suicide risk, previous psychiatric admissions, and recurrent depression) in outpatients with ICD-10 clinical depression. Method : Systematic chart review of 1,013 adults who were assessed and/or treated in a mental health clinic in Santiago, Chile for a major depressive episode. Data were collected on demographics and clinical characteristics of depression. Exposure to ACEs was determined with the Brief Physical and Sexual Abuse Questionnaire, assessing seven types of ACEs. Multivariable logistic regression analysis was used to assess the association between exposure to ACEs and suicidality, previous psychiatric admissions, and recurrence. Predicted probabilities were used for calculations of PAR. Results : Of the 1,001 study participants with complete data, 53.3% had recurrent depression, 13.5% had high suicide risk, and 5.0% had previous psychiatric admissions. Exposure to at least one ACE was recorded for 69.0% of the sample. Exposure to at least one ACE and specific types of ACEs (i.e. childhood sexual abuse and traumatic separation from caregiver) were associated with serious clinical presentations of depression. A dose-response relationship was observed between cumulative exposure to ACEs and the most serious clinical presentations of depression. ACEs were attributed to a significant proportion of disease: 61.6% of previous psychiatric admissions, 45.0% of high suicide risk, and 14.5% of recurrent depression. Conclusions : A substantial proportion of serious clinical presentations of depression among outpatients are associated with ACEs. Early detection of depressive episodes associated with ACEs, and tailored treatment for these patients, may potentially reduce the incidence of serious complications in this population., Competing Interests: No potential conflicts of interest were reported by the authors., (© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
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- 2021
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46. Interventional Study to Evaluate the Clinical Effects and Safety of the Nutraceutical Compound BrainUp-10® in a Cohort of Patients with Alzheimer's Disease: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial.
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Guzman-Martinez L, Farías GA, Tapia JP, Sánchez MP, Fuentes P, Gloger S, and Maccioni RB
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- Aged, Aged, 80 and over, Alzheimer Disease psychology, Cholinesterase Inhibitors therapeutic use, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Outcome, Alzheimer Disease drug therapy, Dietary Supplements adverse effects
- Abstract
Background: Clinically-evaluated nutraceuticals are candidates for Alzheimer's disease (AD) prevention and treatment. Phase I studies showed biological safety of the nutraceutical BrainUp-10®, while a pilot trial demonstrated efficacy for treatment. Cell studies demonstrated neuroprotection. BrainUp-10® blocks tau self-assembly. Apathy is the most common of behavioral alterations., Objective: The aim was to explore efficacy of BrainUp-10® in mitigating cognitive and behavioral symptoms and in providing life quality, in a cohort of Chilean patients with mild to moderate AD., Methods: The was a multicenter, randomized, double blind, placebo-controlled phase II clinical study in mild to moderate AD patients treated with BrainUp-10® daily, while controls received a placebo. Primary endpoint was Apathy (AES scale), while secondary endpoints included Mini-Mental State Examination (MMSE), Trail Making Test (TMT A and TMT B), and Neuropsychiatry Index (NPI). AD blood biomarkers were analyzed. Laboratory tests were applied to all subjects., Results: 82 patients were enrolled. The MMSE score improved significantly at week 24 compared to baseline with tendency to increase, which met the pre-defined superiority criteria. NPI scores improved, the same for caregiver distress at 12th week (p = 0.0557), and the alimentary response (p = 0.0333). Apathy tests showed a statistically significant decrease in group treated with BrainUp-10®, with p = 0.0321 at week 4 and p = 0.0480 at week 12 treatment. A marked decrease in homocysteine was shown with BrainUp-10® (p = 0.0222)., Conclusion: Data show that BrainUp-10® produces a statistically significant improvement in apathy, ameliorating neuropsychiatric distress of patients. There were no compound-related adverse events. BrainUp-10® technology may enable patients to receive the benefits for their cognitive and behavioral problems.
- Published
- 2021
- Full Text
- View/download PDF
47. [Validation of the Childhood Trauma Questionnaire-Short Form in Chile].
- Author
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Behn A, Vöhringer PA, Martínez P, Domínguez AP, González A, Carrasco MI, and Gloger S
- Subjects
- Child, Chile, Factor Analysis, Statistical, Female, Humans, Male, Psychometrics, Reproducibility of Results, Surveys and Questionnaires
- Abstract
Background: Childhood Trauma Questionnaire-Short Form (CTQ-SF) is an instrument to assess child abuse and neglect Aim: to adapt and confirm the psychometric properties of the Spanish version of the CTQ-SF in Chile., Material and Methods: The CTQ-SF was applied to 89 clinically depressed subjects (77.5% women) who consulted at an outpatient mental health clinic. Confirmatory factor analysis (CFA), reliability (Cronbach's α) tests, and convergent validity analyses with clinical markers of complex depression were carried out., Results: The Chilean version of the CTQ-SF demonstrated an acceptable fit to a five-factor model, with adequate psychometric properties. The CFA revealed that a better fit to a five-factor model would be achieved after elimination of two items from the physical neglect scale, the less reliable scale of the questionnaire. The physical abuse scale discriminated between patients with a complex depression versus non-complex depression, and all the CTQ-SF's scales discriminated between patients with high suicide risk and/or history of psychiatric admissions versus those patients without this background., Conclusions: the Chilean version of the CTQ-SF shows evidence of structural and discriminant validity, and reliability, in a clinical sample. Better alternatives to specifically assess the physical neglect construct should be developed.
- Published
- 2020
- Full Text
- View/download PDF
48. Spanish Adaptation and Validation of the Outcome Questionnaire OQ-30.2.
- Author
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Errázuriz P, Opazo S, Behn A, Silva O, and Gloger S
- Abstract
This study assessed the psychometric properties of a Spanish version of the Shortened Outcome Questionnaire (OQ-30.2, Lambert et al., 2004) validated with a sample of 546 patients in an outpatient mental health clinic and 100 non-clinical adults in Chile. Our results show that this measure has similar normative data to the original measure, with a cutoff score for the Chilean population set at 43.36, and the reliable change index at 14. This Spanish OQ-30.2 has good internal consistency (α = 0.90), has concurrent validity with the Depressive, Anxious, and Somatoform disorders measuring scale (Alvarado and Vera, 1991), and is sensitive to change during psychotherapy. Consistent with previous studies, factorial analyses showed that both, the one-factor solution for a general scale and the three-factor solution containing three theoretical scales yielded poor fit estimates. Overall, our results are similar to past research on the OQ-45 and the OQ-30. The short version has adequate psychometric properties, comparable to those of the OQ-45, but provides a gain in application time that could be relevant in the setting of psychotherapy research with large samples, frequent assessments over time, and/or samples that may require more assistance completing items (e.g., low-literacy). We conclude that this measure will be a valuable instrument for research and clinical practice.
- Published
- 2017
- Full Text
- View/download PDF
49. Depression and Attachment: How do Personality Styles and Social Support Influence This Relation?
- Author
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Dagnino P, Pérez C, Gómez A, Gloger S, and Krause M
- Abstract
The purpose of this study is to improve the current understanding of the relation between depression and attachment through the evaluation of the role of personality styles (dependent vs self-critical) and social support in this association. These variables were studied in a clinical sample of 70 depressed outpatients (83% women; M=41.47 years, SD=12.91). Depressive symptomatology was assessed through the Beck Depression Inventory, adult attachment through the Experiences in Close Relationships Scale, social support through the Social Support Questionnaire and dependency and self-criticism through the Depressive Experiences Questionnaire. Mediational and moderation regression analyses were performed. Results show that the association between the dimensions of attachment (anxiety and avoidance) and depression was partially mediated by self-criticism. Furthermore, results demonstrate the role of social support as a moderating variable: when the level of satisfaction with social support was low and the anxiety dimension in the attachment scale was high, as avoidance increased, depressive symptoms increased as well. Results are discussed in relation to their importance for understanding the complex interplay of the variables involved in depression., Competing Interests: Conflict of interest: the authors declare no potential conflict of interest., (©Copyright P. Dagnino et al., 2017.)
- Published
- 2017
- Full Text
- View/download PDF
50. Acceptability Study of "Ascenso": An Online Program for Monitoring and Supporting Patients with Depression in Chile.
- Author
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Espinosa HD, Carrasco Á, Moessner M, Cáceres C, Gloger S, Rojas G, Perez JC, Vanegas J, Bauer S, and Krause M
- Subjects
- Adult, Chile, Female, Humans, Male, Middle Aged, Patient Education as Topic organization & administration, Patient Satisfaction, Recurrence, Risk Factors, Depressive Disorder, Major therapy, Internet, Self Care methods, Telemedicine organization & administration
- Abstract
Background: Major depression is a highly prevalent and severe mental disease. Despite the effective treatment options available, the risk of relapse is high. Interventions based on information and communication technologies generate innovative opportunities to provide support to patients after they completed treatment for depression., Materials and Methods: This acceptability study evaluated the Internet-based program Apoyo, Seguimiento y Cuidado de Enfermedades a partir de Sistemas Operativos (ASCENSO) in terms of its feasibility and acceptability in a sample of 35 patients in Chile., Results: The study reveals high rates of acceptance and satisfaction among patients who actively used the program. As obstacles, patients mentioned technical problems, a lack of contact with other participants, and an insufficient connection between the program and the health service professionals., Conclusions: ASCENSO appears to be a promising complement to regular care for depression. Following improvements of the program based on participants' feedback, future research should evaluate its efficacy and cost-effectiveness.
- Published
- 2016
- Full Text
- View/download PDF
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