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3. Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci

Author

Ishikawa, Taisuke, primary, Masuda, Tatsuo, additional, Hachiya, Tsuyoshi, additional, Dina, Christian, additional, Simonet, Floriane, additional, Nagata, Yuki, additional, Tanck, Michael W T, additional, Sonehara, Kyuto, additional, Glinge, Charlotte, additional, Tadros, Rafik, additional, Khongphatthanayothin, Apichai, additional, Lu, Tzu-Pin, additional, Higuchi, Chihiro, additional, Nakajima, Tadashi, additional, Hayashi, Kenshi, additional, Aizawa, Yoshiyasu, additional, Nakano, Yukiko, additional, Nogami, Akihiko, additional, Morita, Hiroshi, additional, Ohno, Seiko, additional, Aiba, Takeshi, additional, Juárez, Christian Krijger, additional, Mauleekoonphairoj, John, additional, Poovorawan, Yong, additional, Gourraud, Jean-Baptiste, additional, Shimizu, Wataru, additional, Probst, Vincent, additional, Horie, Minoru, additional, Wilde, Arthur A M, additional, Redon, Richard, additional, Juang, Jyh-Ming Jimmy, additional, Nademanee, Koonlawee, additional, Bezzina, Connie R, additional, Barc, Julien, additional, Tanaka, Toshihiro, additional, Okada, Yukinori, additional, Schott, Jean-Jacques, additional, and Makita, Naomasa, additional

Published
2024
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4. A comprehensive evaluation of the genetic architecture of sudden cardiac arrest

Author

Ashar, Foram N, Mitchell, Rebecca N, Albert, Christine M, Newton-Cheh, Christopher, Brody, Jennifer A, Müller-Nurasyid, Martina, Moes, Anna, Meitinger, Thomas, Mak, Angel, Huikuri, Heikki, Junttila, M Juhani, Goyette, Philippe, Pulit, Sara L, Pazoki, Raha, Tanck, Michael W, Blom, Marieke T, Zhao, XiaoQing, Havulinna, Aki S, Jabbari, Reza, Glinge, Charlotte, Tragante, Vinicius, Escher, Stefan A, Chakravarti, Aravinda, Ehret, Georg, Coresh, Josef, Li, Man, Prineas, Ronald J, Franco, Oscar H, Kwok, Pui-Yan, Lumley, Thomas, Dumas, Florence, McKnight, Barbara, Rotter, Jerome I, Lemaitre, Rozenn N, Heckbert, Susan R, O’Donnell, Christopher J, Hwang, Shih-Jen, Tardif, Jean-Claude, VanDenburgh, Martin, Uitterlinden, André G, Hofman, Albert, Stricker, Bruno HC, de Bakker, Paul IW, Franks, Paul W, Jansson, Jan-Hakan, Asselbergs, Folkert W, Halushka, Marc K, Maleszewski, Joseph J, Tfelt-Hansen, Jacob, Engstrøm, Thomas, Salomaa, Veikko, Virmani, Renu, Kolodgie, Frank, Wilde, Arthur AM, Tan, Hanno L, Bezzina, Connie R, Eijgelsheim, Mark, Rioux, John D, Jouven, Xavier, Kääb, Stefan, Psaty, Bruce M, Siscovick, David S, Arking, Dan E, and Sotoodehnia, Nona

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Prevention, Heart Disease, Human Genome, Genetics, Clinical Research, Heart Disease - Coronary Heart Disease, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Arrhythmias, Cardiac, Body Mass Index, Coronary Artery Disease, Death, Sudden, Cardiac, Female, Genome-Wide Association Study, Heart Conduction System, Humans, Male, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, Sex Factors, Sudden cardiac arrest, Genome-wide association study, Mendelian randomization, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

AimsSudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA.Methods and resultsWe carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also exploited Mendelian randomization (MR) methods using cross-trait multi-variant genetic risk score associations (GRSA) to assess causal relationships of 18 risk factors with SCA. No variants were associated with SCA at genome-wide significance, nor were common variants in candidate arrhythmia genes associated with SCA at nominal significance. Using cross-trait GRSA, we established genetic correlation between SCA and (i) coronary artery disease (CAD) and traditional CAD risk factors (blood pressure, lipids, and diabetes), (ii) height and BMI, and (iii) electrical instability traits (QT and atrial fibrillation), suggesting aetiologic roles for these traits in SCA risk.ConclusionsOur findings show that a comprehensive approach to the genetic architecture of SCA can shed light on the determinants of a complex life-threatening condition with multiple influencing factors in the general population. The results of this genetic analysis, both positive and negative findings, have implications for evaluating the genetic architecture of patients with a family history of SCA, and for efforts to prevent SCA in high-risk populations and the general community.

Published
2018

5. Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Author

Barc, Julien, Tadros, Rafik, Glinge, Charlotte, Chiang, David Y., Jouni, Mariam, Simonet, Floriane, Jurgens, Sean J., Baudic, Manon, Nicastro, Michele, Potet, Franck, Offerhaus, Joost A., Walsh, Roddy, Choi, Seung Hoan, Verkerk, Arie O., Mizusawa, Yuka, Anys, Soraya, Minois, Damien, Arnaud, Marine, Duchateau, Josselin, Wijeyeratne, Yanushi D., Muir, Alison, Papadakis, Michael, Castelletti, Silvia, Torchio, Margherita, Ortuño, Cristina Gil, Lacunza, Javier, Giachino, Daniela F., Cerrato, Natascia, Martins, Raphaël P., Campuzano, Oscar, Van Dooren, Sonia, Thollet, Aurélie, Kyndt, Florence, Mazzanti, Andrea, Clémenty, Nicolas, Bisson, Arnaud, Corveleyn, Anniek, Stallmeyer, Birgit, Dittmann, Sven, Saenen, Johan, Noël, Antoine, Honarbakhsh, Shohreh, Rudic, Boris, Marzak, Halim, Rowe, Matthew K., Federspiel, Claire, Le Page, Sophie, Placide, Leslie, Milhem, Antoine, Barajas-Martinez, Hector, Beckmann, Britt-Maria, Krapels, Ingrid P., Steinfurt, Johannes, Winkel, Bo Gregers, Jabbari, Reza, Shoemaker, Moore B., Boukens, Bas J., Škorić-Milosavljević, Doris, Bikker, Hennie, Manevy, Federico C., Lichtner, Peter, Ribasés, Marta, Meitinger, Thomas, Müller-Nurasyid, Martina, Veldink, Jan H., van den Berg, Leonard H., Van Damme, Philip, Cusi, Daniele, Lanzani, Chiara, Rigade, Sidwell, Charpentier, Eric, Baron, Estelle, Bonnaud, Stéphanie, Lecointe, Simon, Donnart, Audrey, Le Marec, Hervé, Chatel, Stéphanie, Karakachoff, Matilde, Bézieau, Stéphane, London, Barry, Tfelt-Hansen, Jacob, Roden, Dan, Odening, Katja E., Cerrone, Marina, Chinitz, Larry A., Volders, Paul G., van de Berg, Maarten P., Laurent, Gabriel, Faivre, Laurence, Antzelevitch, Charles, Kääb, Stefan, Arnaout, Alain Al, Dupuis, Jean-Marc, Pasquie, Jean-Luc, Billon, Olivier, Roberts, Jason D., Jesel, Laurence, Borggrefe, Martin, Lambiase, Pier D., Mansourati, Jacques, Loeys, Bart, Leenhardt, Antoine, Guicheney, Pascale, Maury, Philippe, Schulze-Bahr, Eric, Robyns, Tomas, Breckpot, Jeroen, Babuty, Dominique, Priori, Silvia G., Napolitano, Carlo, de Asmundis, Carlo, Brugada, Pedro, Brugada, Ramon, Arbelo, Elena, Brugada, Josep, Mabo, Philippe, Behar, Nathalie, Giustetto, Carla, Molina, Maria Sabater, Gimeno, Juan R., Hasdemir, Can, Schwartz, Peter J., Crotti, Lia, McKeown, Pascal P., Sharma, Sanjay, Behr, Elijah R., Haissaguerre, Michel, Sacher, Frédéric, Rooryck, Caroline, Tan, Hanno L., Remme, Carol A., Postema, Pieter G., Delmar, Mario, Ellinor, Patrick T., Lubitz, Steven A., Gourraud, Jean-Baptiste, Tanck, Michael W., George, Jr., Alfred L., MacRae, Calum A., Burridge, Paul W., Dina, Christian, Probst, Vincent, Wilde, Arthur A., Schott, Jean-Jacques, Redon, Richard, and Bezzina, Connie R.

Published
2022
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7. Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand

Author

Makarawate, Pattarapong, Glinge, Charlotte, Khongphatthanayothin, Apichai, Walsh, Roddy, Mauleekoonphairoj, John, Amnueypol, Montawatt, Prechawat, Somchai, Wongcharoen, Wanwarang, Krittayaphong, Rungroj, Anannab, Alisara, Lichtner, Peter, Meitinger, Thomas, Tjong, Fleur V.Y., Lieve, Krystien V.V., Amin, Ahmad S., Sahasatas, Dujdao, Ngarmukos, Tachapong, Wichadakul, Duangdao, Payungporn, Sunchai, Sutjaporn, Boosamas, Wandee, Pharawee, Poovorawan, Yong, Tfelt-Hansen, Jacob, Tanck, Michael W.T., Tadros, Rafik, Wilde, Arthur A.M., Bezzina, Connie R., Veerakul, Gumpanart, and Nademanee, Koonlawee

Published
2020
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9. Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics

Author

Stampe, Niels Kjær, primary, Ottenheijm, Maud Eline, additional, Drici, Lylia, additional, Wewer Albrechtsen, Nicolai J, additional, Nielsen, Annelaura Bach, additional, Christoffersen, Christina, additional, Warming, Peder Emil, additional, Engstrøm, Thomas, additional, Winkel, Bo Gregers, additional, Jabbari, Reza, additional, Tfelt-Hansen, Jacob, additional, and Glinge, Charlotte, additional

Published
2023
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10. Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Author

Barc, Julien, Tadros, Rafik, Glinge, Charlotte, Chiang, David Y., Jouni, Mariam, Simonet, Floriane, Jurgens, Sean J., Baudic, Manon, Nicastro, Michele, Potet, Franck, Offerhaus, Joost A., Walsh, Roddy, Choi, Seung Hoan, Verkerk, Arie O., Mizusawa, Yuka, Anys, Soraya, Minois, Damien, Arnaud, Marine, Duchateau, Josselin, Wijeyeratne, Yanushi D., Muir, Alison, Papadakis, Michael, Castelletti, Silvia, Torchio, Margherita, Ortuño, Cristina Gil, Lacunza, Javier, Giachino, Daniela F., Cerrato, Natascia, Martins, Raphaël P., Campuzano, Oscar, Van Dooren, Sonia, Thollet, Aurélie, Kyndt, Florence, Mazzanti, Andrea, Clémenty, Nicolas, Bisson, Arnaud, Corveleyn, Anniek, Stallmeyer, Birgit, Dittmann, Sven, Saenen, Johan, Noël, Antoine, Honarbakhsh, Shohreh, Rudic, Boris, Marzak, Halim, Rowe, Matthew K., Federspiel, Claire, Le Page, Sophie, Placide, Leslie, Milhem, Antoine, Barajas-Martinez, Hector, Beckmann, Britt-Maria, Krapels, Ingrid P., Steinfurt, Johannes, Winkel, Bo Gregers, Jabbari, Reza, Shoemaker, Moore B., Boukens, Bas J., Škorić-Milosavljević, Doris, Bikker, Hennie, Manevy, Federico, Lichtner, Peter, Ribasés, Marta, Meitinger, Thomas, Müller-Nurasyid, Martina, Veldink, Jan H., van den Berg, Leonard H., Van Damme, Philip, Cusi, Daniele, Lanzani, Chiara, Rigade, Sidwell, Charpentier, Eric, Baron, Estelle, Bonnaud, Stéphanie, Lecointe, Simon, Donnart, Audrey, Le Marec, Hervé, Chatel, Stéphanie, Karakachoff, Matilde, Bézieau, Stéphane, London, Barry, Tfelt-Hansen, Jacob, Roden, Dan, Odening, Katja E., Cerrone, Marina, Chinitz, Larry A., Volders, Paul G., van de Berg, Maarten P., Laurent, Gabriel, Faivre, Laurence, Antzelevitch, Charles, Kääb, Stefan, Arnaout, Alain Al, Dupuis, Jean-Marc, Pasquie, Jean-Luc, Billon, Olivier, Roberts, Jason D., Jesel, Laurence, Borggrefe, Martin, Lambiase, Pier D., Mansourati, Jacques, Loeys, Bart, Leenhardt, Antoine, Guicheney, Pascale, Maury, Philippe, Schulze-Bahr, Eric, Robyns, Tomas, Breckpot, Jeroen, Babuty, Dominique, Priori, Silvia G., Napolitano, Carlo, de Asmundis, Carlo, Brugada, Pedro, Brugada, Ramon, Arbelo, Elena, Brugada, Josep, Mabo, Philippe, Behar, Nathalie, Giustetto, Carla, Molina, Maria Sabater, Gimeno, Juan R., Hasdemir, Can, Schwartz, Peter J., Crotti, Lia, McKeown, Pascal P., Sharma, Sanjay, Behr, Elijah R., Haissaguerre, Michel, Sacher, Frédéric, Rooryck, Caroline, Tan, Hanno L., Remme, Carol A., Postema, Pieter G., Delmar, Mario, Ellinor, Patrick T., Lubitz, Steven A., Gourraud, Jean-Baptiste, Tanck, Michael W., George, Jr., Alfred L., MacRae, Calum A., Burridge, Paul W., Dina, Christian, Probst, Vincent, Wilde, Arthur A., Schott, Jean-Jacques, Redon, Richard, and Bezzina, Connie R.

Published
2022
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12. Bleeding risk and P2Y12 inhibitors in all-comer patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: a single-centre cohort study

Author

Jacobsen, Mia Ravn, primary, Jabbari, Reza, additional, Engstrøm, Thomas, additional, Grove, Erik Lerkevang, additional, Glinge, Charlotte, additional, Pedersen, Frants, additional, Holmvang, Lene, additional, Køber, Lars, additional, Torp-Pedersen, Christian, additional, Maeng, Michael, additional, Veien, Karsten, additional, Freeman, Phillip, additional, Charlot, Mette Gitz, additional, Kelbæk, Henning, additional, and Sørensen, Rikke, additional

Published
2023
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13. A Multiple Kernel Learning Framework to Investigate the Relationship Between Ventricular Fibrillation and First Myocardial Infarction

Author

Marciniak, Maciej, Arevalo, Hermenegild, Tfelt-Hansen, Jacob, Ahtarovski, Kiril A., Jespersen, Thomas, Jabbari, Reza, Glinge, Charlotte, Vejlstrup, Niels, Engstrom, Thomas, Maleckar, Mary M., McLeod, Kristin, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Pop, Mihaela, editor, and Wright, Graham A, editor

Published
2017
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14. From CMR Image to Patient-Specific Simulation and Population-Based Analysis: Tutorial for an Openly Available Image-Processing Pipeline

Author

Marciniak, Maciej, Arevalo, Hermenegild, Tfelt-Hansen, Jacob, Jespersen, Thomas, Jabbari, Reza, Glinge, Charlotte, Ahtarovski, Kiril A., Vejlstrup, Niels, Engstrom, Thomas, Maleckar, Mary M., McLeod, Kristin, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Mansi, Tommaso, editor, McLeod, Kristin, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, and Young, Alistair, editor

Published
2017
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17. Risk of Sudden Infant Death Syndrome Among Siblings of Children Who Died of Sudden Infant Death Syndrome in Denmark

Author

Glinge, Charlotte, primary, Rossetti, Sára, additional, Oestergaard, Louise Bruun, additional, Stampe, Niels Kjær, additional, Lynge, Thomas Hadberg, additional, Skals, Regitze, additional, Winkel, Bo Gregers, additional, Lodder, Elisabeth M., additional, Bezzina, Connie R., additional, Gislason, Gunnar, additional, Banner, Jytte, additional, Behr, Elijah R., additional, Torp-Pedersen, Christian, additional, Jabbari, Reza, additional, and Tfelt-Hansen, Jacob, additional

Published
2023
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19. P074: Long-Term Cause-Specific Mortality in Hodgkin Lymphoma Patients – A Nationwide Danish Cohort Study

Author

Rossetti, Sára, primary, Juul, Sidsel Jacobsen, additional, Eriksson, Frank, additional, Warming, Peder Emil, additional, Glinge, Charlotte, additional, El-Galaly, Tarec Christoffer, additional, Christensen, Jacob Haaber, additional, Kamper, Peter, additional, De Nully Brown, Peter, additional, Maraldo, Maja Vestmø, additional, Tfelt-Hansen, Jacob, additional, and Hutchings, Martin, additional

Published
2022
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22. A Multiple Kernel Learning Framework to Investigate the Relationship Between Ventricular Fibrillation and First Myocardial Infarction

Author

Marciniak, Maciej, primary, Arevalo, Hermenegild, additional, Tfelt-Hansen, Jacob, additional, Ahtarovski, Kiril A., additional, Jespersen, Thomas, additional, Jabbari, Reza, additional, Glinge, Charlotte, additional, Vejlstrup, Niels, additional, Engstrom, Thomas, additional, Maleckar, Mary M., additional, and McLeod, Kristin, additional

Published
2017
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23. From CMR Image to Patient-Specific Simulation and Population-Based Analysis: Tutorial for an Openly Available Image-Processing Pipeline

Author

Marciniak, Maciej, primary, Arevalo, Hermenegild, additional, Tfelt-Hansen, Jacob, additional, Jespersen, Thomas, additional, Jabbari, Reza, additional, Glinge, Charlotte, additional, Ahtarovski, Kiril A., additional, Vejlstrup, Niels, additional, Engstrom, Thomas, additional, Maleckar, Mary M., additional, and McLeod, Kristin, additional

Published
2017
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24. BS-513-02 GENOME-WIDE ASSOCIATION ANALYSES IDENTIFY NOVEL BRUGADA SYNDROME RISK LOCI AND HIGHLIGHT A NEW MECHANISM OF SODIUM CHANNEL REGULATION IN DISEASE SUSCEPTIBILITY

Author

Barc, Julien, primary, Tadros, Rafik, additional, Glinge, Charlotte, additional, Chiang, David Y., additional, jouni, Mariam, additional, Simonet, Floriane, additional, Tanck, Michael, additional, George, Alfred L., additional, MacRae, Calum A., additional, Burridge, Paul, additional, Dina, Christian, additional, Probst, Vincent, additional, Wilde, Arthur A.M., additional, Schott, Jean-Jacques, additional, Redon, Richard, additional, and Bezzina, Connie R., additional

Published
2022
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25. Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy

Author

Madsen, Jasmine Melissa, primary, Glinge, Charlotte, additional, Jabbari, Reza, additional, Nepper-Christensen, Lars, additional, Høfsten, Dan Eik, additional, Tilsted, Hans-Henrik, additional, Holmvang, Lene, additional, Pedersen, Frants, additional, Joshi, Francis Richard, additional, Sørensen, Rikke, additional, Bang, Lia Evi, additional, Bøtker, Hans Erik, additional, Terkelsen, Christian Juhl, additional, Mæng, Michael, additional, Jensen, Lisette Okkels, additional, Aarøe, Jens, additional, Kelbæk, Henning, additional, Torp-Pedersen, Christian, additional, Køber, Lars, additional, Lønborg, Jacob Thomsen, additional, and Engstrøm, Thomas, additional

Published
2021
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26. Combined In-silico and Machine Learning Approaches Toward Predicting Arrhythmic Risk in Post-infarction Patients

Author

Maleckar, Mary M., primary, Myklebust, Lena, additional, Uv, Julie, additional, Florvaag, Per Magne, additional, Strøm, Vilde, additional, Glinge, Charlotte, additional, Jabbari, Reza, additional, Vejlstrup, Niels, additional, Engstrøm, Thomas, additional, Ahtarovski, Kiril, additional, Jespersen, Thomas, additional, Tfelt-Hansen, Jacob, additional, Naumova, Valeriya, additional, and Arevalo, Hermenegild, additional

Published
2021
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27. Clopidogrel, prasugrel, and ticagrelor for all-comers with ST-segment elevation myocardial infarction

Author

Jacobsen, Mia Ravn, primary, Engstrøm, Thomas, additional, Torp-Pedersen, Christian, additional, Gislason, Gunnar, additional, Glinge, Charlotte, additional, Butt, Jawad Haider, additional, Fosbøl, Emil Loldrup, additional, Holmvang, Lene, additional, Pedersen, Frants, additional, Køber, Lars, additional, Jabbari, Reza, additional, and Sørensen, Rikke, additional

Published
2021
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28. B-PO02-022 COMBINING SIMULATION AND MACHINE LEARNING TO ACCURATELY PREDICT ARRHYTHMIC RISK IN POST-INFARCTION PATIENTS

Author

Maleckar, Mary M., primary, Magne Florvaag, Per, additional, Strøm, Vilde Nyrønning, additional, Glinge, Charlotte, additional, Jabbari, Reza, additional, Vejlstrup, Niels, additional, Engstrom, Thomas, additional, Ahtarovski, Kiril, additional, Jespersen, Thomas, additional, Tfelt-Hansen, Jacob, additional, Naumova, Valeriya, additional, and Arevalo, Hermenegild J., additional

Published
2021
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30. Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

Author

Walsh, Roddy, primary, Lahrouchi, Najim, additional, Tadros, Rafik, additional, Kyndt, Florence, additional, Glinge, Charlotte, additional, Postema, Pieter G., additional, Amin, Ahmad S., additional, Nannenberg, Eline A., additional, Ware, James S., additional, Whiffin, Nicola, additional, Mazzarotto, Francesco, additional, Škorić-Milosavljević, Doris, additional, Krijger, Christian, additional, Arbelo, Elena, additional, Babuty, Dominique, additional, Barajas-Martinez, Hector, additional, Beckmann, Britt M., additional, Bézieau, Stéphane, additional, Bos, J. Martijn, additional, Breckpot, Jeroen, additional, Campuzano, Oscar, additional, Castelletti, Silvia, additional, Celen, Candan, additional, Clauss, Sebastian, additional, Corveleyn, Anniek, additional, Crotti, Lia, additional, Dagradi, Federica, additional, de Asmundis, Carlo, additional, Denjoy, Isabelle, additional, Dittmann, Sven, additional, Ellinor, Patrick T., additional, Ortuño, Cristina Gil, additional, Giustetto, Carla, additional, Gourraud, Jean-Baptiste, additional, Hazeki, Daisuke, additional, Horie, Minoru, additional, Ishikawa, Taisuke, additional, Itoh, Hideki, additional, Kaneko, Yoshiaki, additional, Kanters, Jørgen K., additional, Kimoto, Hiroki, additional, Kotta, Maria-Christina, additional, Krapels, Ingrid P.C., additional, Kurabayashi, Masahiko, additional, Lazarte, Julieta, additional, Leenhardt, Antoine, additional, Loeys, Bart L., additional, Lundin, Catarina, additional, Makiyama, Takeru, additional, Mansourati, Jacques, additional, Martins, Raphaël P., additional, Mazzanti, Andrea, additional, Mörner, Stellan, additional, Napolitano, Carlo, additional, Ohkubo, Kimie, additional, Papadakis, Michael, additional, Rudic, Boris, additional, Molina, Maria Sabater, additional, Sacher, Frédéric, additional, Sahin, Hatice, additional, Sarquella-Brugada, Georgia, additional, Sebastiano, Regina, additional, Sharma, Sanjay, additional, Sheppard, Mary N., additional, Shimamoto, Keiko, additional, Shoemaker, M.Benjamin, additional, Stallmeyer, Birgit, additional, Steinfurt, Johannes, additional, Tanaka, Yuji, additional, Tester, David J., additional, Usuda, Keisuke, additional, van der Zwaag, Paul A., additional, Van Dooren, Sonia, additional, Van Laer, Lut, additional, Winbo, Annika, additional, Winkel, Bo G., additional, Yamagata, Kenichiro, additional, Zumhagen, Sven, additional, Volders, Paul G.A., additional, Lubitz, Steven A., additional, Antzelevitch, Charles, additional, Platonov, Pyotr G., additional, Odening, Katja E., additional, Roden, Dan M., additional, Roberts, Jason D., additional, Skinner, Jonathan R., additional, Tfelt-Hansen, Jacob, additional, van den Berg, Maarten P., additional, Olesen, Morten S., additional, Lambiase, Pier D., additional, Borggrefe, Martin, additional, Hayashi, Kenshi, additional, Rydberg, Annika, additional, Nakajima, Tadashi, additional, Yoshinaga, Masao, additional, Saenen, Johan B., additional, Kääb, Stefan, additional, Brugada, Pedro, additional, Robyns, Tomas, additional, Giachino, Daniela F., additional, Ackerman, Michael J., additional, Brugada, Ramon, additional, Brugada, Josep, additional, Gimeno, Juan R., additional, Hasdemir, Can, additional, Guicheney, Pascale, additional, Priori, Silvia G., additional, Schulze-Bahr, Eric, additional, Makita, Naomasa, additional, Schwartz, Peter J., additional, Shimizu, Wataru, additional, Aiba, Takeshi, additional, Schott, Jean-Jacques, additional, Redon, Richard, additional, Ohno, Seiko, additional, Probst, Vincent, additional, Arnaout, Alain Al, additional, Amelot, Mathieu, additional, Anselme, Frédéric, additional, Billon, Olivier, additional, Defaye, Pascal, additional, Dupuis, Jean-Marc, additional, Jesel, Laurence, additional, Laurent, Gabriel, additional, Maury, Philippe, additional, Pasquie, Jean-Luc, additional, Wiart, Francois, additional, Behr, Elijah R., additional, Barc, Julien, additional, and Bezzina, Connie R., additional

Published
2021
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31. Erratum: Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure (PLoS ONE (2020)15:2(e0226936)Doi: 10.1371/journal.pone.0226936)

Author

Glinge, Charlotte, Engstrøm, Thomas, Midgley, Sofie E., Tanck, Michael W. T., Madsen, Jeppe Ekstrand Halkjær, Pedersen, Frants, Jacobsen, Mia Ravn, Lodder, Elisabeth M., Al-Hussainy, Nour R., Stampe, Niels Kjær, Trebbien, Ramona, Køber, Lars, Gerds, Thomas, Torp-Pedersen, Christian, Fischer, Thea K. lsen, Bezzina, Connie R., Tfelt-Hansen, Jacob, Jabbari, Reza, Epidemiology and Data Science, APH - Methodology, Cardiology, Human Genetics, and ACS - Heart failure & arrhythmias

Abstract

The fifteenth author's initials are indexed incorrectly in PubMed. The correct initials are: Fischer TK.

Published
2020

35. Correction: Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

Author

Glinge, Charlotte, primary, Engstrøm, Thomas, additional, Midgley, Sofie E., additional, Tanck, Michael W. T., additional, Madsen, Jeppe Ekstrand Halkjær, additional, Pedersen, Frants, additional, Jacobsen, Mia Ravn, additional, Lodder, Elisabeth M., additional, Al-Hussainy, Nour R., additional, Stampe, Niels Kjær, additional, Trebbien, Ramona, additional, Køber, Lars, additional, Gerds, Thomas, additional, Torp-Pedersen, Christian, additional, Fischer, Thea Kølsen, additional, Bezzina, Connie R., additional, Tfelt-Hansen, Jacob, additional, and Jabbari, Reza, additional

Published
2020
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37. Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

Author

Glinge, Charlotte, primary, Engstrøm, Thomas, additional, Midgley, Sofie E., additional, Tanck, Michael W. T., additional, Madsen, Jeppe Ekstrand Halkjær, additional, Pedersen, Frants, additional, Ravn Jacobsen, Mia, additional, Lodder, Elisabeth M., additional, Al-Hussainy, Nour R., additional, Kjær Stampe, Niels, additional, Trebbien, Ramona, additional, Køber, Lars, additional, Gerds, Thomas, additional, Torp-Pedersen, Christian, additional, Kølsen Fischer, Thea, additional, Bezzina, Connie R., additional, Tfelt-Hansen, Jacob, additional, and Jabbari, Reza, additional

Published
2020
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38. Potassium Disturbances and Risk of Ventricular Fibrillation Among Patients With ST‐Segment–Elevation Myocardial Infarction

Author

Ravn Jacobsen, Mia, primary, Jabbari, Reza, additional, Glinge, Charlotte, additional, Kjær Stampe, Niels, additional, Butt, Jawad Haider, additional, Blanche, Paul, additional, Lønborg, Jacob, additional, Wendelboe Nielsen, Olav, additional, Køber, Lars, additional, Torp‐Pedersen, Christian, additional, Pedersen, Frants, additional, Tfelt‐Hansen, Jacob, additional, and Engstrøm, Thomas, additional

Published
2020
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39. Subsequent Event Risk in Individuals With Established Coronary Heart Disease

Author

Patel, Riyaz S, Tragante, Vinicius, Schmidt, Amand F, McCubrey, Raymond O, Holmes, Michael V, Howe, Laurence J, Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S, Kaminski, Karol A, Muehlschlegel, Jochen D, Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V, Behloui, Hassan, Boeckx, Bram, Braund, Peter S, Breitling, Lutz P, Delgado, Graciela, Duarte, Nubia E, Dubé, Marie-Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M, Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A, Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjärvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A, Levin, Daniel, Lyytikäinen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P, Nikus, Kjell, Pilbrow, Anna P, Ploski, Rafal, Klungel, Olaf H, Maitland-van der Zee, Anke H, Afd Pharmacoepi & Clinical Pharmacology, and Pharmacoepidemiology and Clinical Pharmacology

Subjects
myocardial infarction, genetics, prognosis, coronary artery disease, sedundary preventation
Abstract

BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

Published
2019

40. Subsequent event risk in individuals with established coronary heart disease : design and rationale of the GENIUS-CHD consortium

Author

Patel, Riyaz, Tragante, Vinicius, Schmidt, Amand, McCubrey, Raymond, Holmes, Michael, Howe, Laurence, Direk, Kenan, Akerblom, Axel, Leander, Karin, Virani, Salim, Kaminski, Karol, Muehlschlegel, Jochen, Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina, Behlouli, Hassan, Boeckx, Bram, Braund, Peter, Breitling, Lutz, Delgado, Graciela, Duarte, Nubia, Dube, Marie-Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel, Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav, Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjarvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra, Levin, Daniel, Lyytikainen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher, Nikus, Kjell, Pilbrow, Anna, Ploski, Rafal, Sun, Yan, Tanck, Michael, Tang, W.H., Trompet, Stella, van der Laan, Sander, van Setten, Jessica, Vilmundarson, Ragnar, Anselmi, Chiara, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John, Carruthers, Kathryn, Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engstrom, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo, Marziliano, Nicola, Muhlestein, Joseph, Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph, Samman-Tahhan, Ayman, Sandesara, Pratik, Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur, Ford, Ian, Stott, David, Algra, Ale, Andreassi, Maria, Ardissino, Diego, Arsenault, Benoit, Ballantyne, Christie, Bergmeijer, Thomas, Bezzina, Connie, Body, Simon, Boersma, Eric, Bogaty, Peter, Bots, Michiel, Brenner, Hermann, Brugts, Jasper, Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda, Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Doughty, Robert, Drexel, Heinz, Engert, James, Fox, Keith, Girelli, Domenico, Grobbee, Diederick, Hagstrom, Emil, Hazen, Stanley, Held, Claes, Hemingway, Harry, Hoefer, Imo, Hovingh, G., Jabbari, Reza, Johnson, Julie, Jukema, J., Kaczor, Marcin, Kahonen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf, Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari, Lehtimaki, Terho, Lindholm, Daniel, Mahmoodi, B., Maitland-van der Zee, Anke, McPherson, Ruth, Melander, Olle, Metspalu, Andres, Niemcunowicz-Janica, Anna, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin, Pasterkamp, Gerard, Pepine, Carl, Pereira, Alexandre, Pilote, Louise, Quyyumi, Arshed, Richards, A., Sanak, Marek, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Smith, J., Spertus, John, Stender, Steen, Stewart, Alexandre, Szczeklik, Wojciech, Szpakowicz, Anna, Tardif, Jean-Claude, ten Berg, Jurrien, Tfelt-Hansen, Jacob, Thanassoulis, George, Thiery, Joachim, Torp-Pedersen, Christian, van der Graaf, Yolanda, Visseren, Frank, Waltenberger, Johannes, van der Harst, Pim, Lang, Chim, Sattar, Naveed, Cameron, Vicky, Anderson, Jeffrey, Brophy, James, Pare, Guillaume, Horne, Benjamin, Marz, Winfried, Wallentin, Lars, Samani, Nilesh, Hingorani, Aroon, and Asselbergs, Folkert

Subjects
myocardial infarction, genetics, prognosis, coronary artery disease, secondary prevention
Abstract

BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%–91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

Published
2019

41. Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction

Author

Adriaens, Michiel E., primary, Lodder, Elisabeth M., additional, Moreno‐Moral, Aida, additional, Šilhavý, Jan, additional, Heinig, Matthias, additional, Glinge, Charlotte, additional, Belterman, Charly, additional, Wolswinkel, Rianne, additional, Petretto, Enrico, additional, Pravenec, Michal, additional, Remme, Carol Ann, additional, and Bezzina, Connie R., additional

Published
2018
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42. Sudden Cardiac Death:Pharmacotherapy and Proarrhythmic Drugs: A Nationwide Cohort Study in Denmark

Author

Risgaard, Bjarke, Winkel, Bo Gregers, Jabbari, Reza, Lynge, Thomas Hadberg, Wissenberg, Mads, Glinge, Charlotte, Haunsø, Stig, Behr, Elijah R., Fink-Jensen, Anders, Gislason, Gunnar Hilmar, and Tfelt-Hansen, Jacob

Subjects
pharmacotherapy, sudden arrhythmic death, drugs, sudden cardiac death
Abstract

Objectives This study sought to describe the use of pharmacotherapy in a nationwide cohort of young patients with sudden cardiac death (SCD). Background Several drugs have been associated with an increased risk of SCD and sudden arrhythmic death syndrome (SADS). It remains unclear how pharmacotherapy may contribute to the overall burden of SCD in the general population. Methods This was a nationwide study that included all deaths that occurred between 2000 and 2009 and between 2007 and 2009 in people age 1 to 35 years and 36 to 49 years, respectively. Two physicians identified all SCDs through review of death certificates. Autopsy reports were collected. Pharmacotherapy prescribed within 90 days before SCD was identified in the Danish Registry of Medicinal Product Statistics. Results We identified 1,363 SCDs; median age was 38 years (interquartile range: 29 to 45 years), and 72% (n = 975) were men. Autopsy was performed in 55%. Overall, 58% of SCD cases (n = 786) received at least 1 drug within 90 days before death. The most common drugs were analgesic drugs (n = 239; 18%), antihypertensive drugs (n = 234; 17%), and antibiotic drugs (n = 218; 16%). After multivariable adjustment, prescription of “brugadogenic” drugs or >1 QT-prolonging drug was associated with an increased risk of SADS compared with explained SCD (odds ratio: 2.16 [95% confidence interval: 1.12 to 4.17] and 2.91 [95% confidence interval: 1.46 to 5.81], respectively). Conclusions Pharmacotherapy was identified in 58% of the SCD cases. After multivariable adjustment, there was a 2- and 3-fold increased risk of SADS compared with explained SCD in patients receiving brugadogenic drugs or >1 QT-prolonging drug, respectively. Identification of high-risk patients is warranted to lower the burden of SCD.

Published
2017

47. Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction

Author

Jabbari, Reza, primary, Jabbari, Javad, additional, Glinge, Charlotte, additional, Risgaard, Bjarke, additional, Sattler, Stefan, additional, Winkel, Bo Gregers, additional, Terkelsen, Christian Juhl, additional, Tilsted, Hans-Henrik, additional, Jensen, Lisette Okkels, additional, Hougaard, Mikkel, additional, Haunsø, Stig, additional, Engstrøm, Thomas, additional, Albert, Christine M., additional, and Tfelt-Hansen, Jacob, additional

Published
2017
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48. Sudden Cardiac Death

Author

Risgaard, Bjarke, primary, Winkel, Bo Gregers, additional, Jabbari, Reza, additional, Lynge, Thomas Hadberg, additional, Wissenberg, Mads, additional, Glinge, Charlotte, additional, Haunsø, Stig, additional, Behr, Elijah R., additional, Fink-Jensen, Anders, additional, Gislason, Gunnar Hilmar, additional, and Tfelt-Hansen, Jacob, additional

Published
2017
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50. Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations

Author

Glinge, Charlotte, primary, Clauss, Sebastian, additional, Boddum, Kim, additional, Jabbari, Reza, additional, Jabbari, Javad, additional, Risgaard, Bjarke, additional, Tomsits, Philipp, additional, Hildebrand, Bianca, additional, Kääb, Stefan, additional, Wakili, Reza, additional, Jespersen, Thomas, additional, and Tfelt-Hansen, Jacob, additional

Published
2017
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